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<!--
UID=107513
ConceptID=C0553980
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Endomyocardial fibrosis</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>107513</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0553980</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding; Pathologic Function</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
<td>Endocardial fibrosis</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Endomyocardial fibrosis (398716006); Endomyocardial sclerosis (398716006)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0006685">HP:0006685</a></td></tr>
<tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0006746" target="_blank">MONDO:0006746</a></td></tr>
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">The presence of excessive connective tissue in the endocardium. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Endomyocardial fibrosis</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/2848" ref="tree=MeSH" title="MedGen record for Disorder of cardiovascular system">Disorder of cardiovascular system</a></span><ul><li><span class="TLline"><a href="/medgen/116727" ref="tree=MeSH" title="MedGen record for Abnormality of the cardiovascular system">Abnormality of the cardiovascular system</a></span><ul><li><span class="TLline"><a href="/medgen/892473" ref="tree=MeSH" title="MedGen record for Abnormal cardiovascular system morphology">Abnormal cardiovascular system morphology</a></span><ul><li><span class="TLline"><a href="/medgen/6748" ref="tree=MeSH" title="MedGen record for Abnormal heart morphology">Abnormal heart morphology</a></span><ul><li><span class="TLline"><a href="/medgen/867299" ref="tree=MeSH" title="MedGen record for Abnormal endocardium morphology">Abnormal endocardium morphology</a></span><ul><li><span class="matched_ds">Endomyocardial fibrosis</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_61525"><div><strong>Idiopathic hypereosinophilic syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>61525</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0206141</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">PDGFRA-associated chronic eosinophilic leukemia is a form of blood cell cancer characterized by an elevated number of cells called eosinophils in the blood. These cells help fight infections by certain parasites and are involved in the inflammation associated with allergic reactions. However, these circumstances do not account for the increased number of eosinophils in PDGFRA-associated chronic eosinophilic leukemia.\n\nAnother characteristic feature of PDGFRA-associated chronic eosinophilic leukemia is organ damage caused by the excess eosinophils. Eosinophils release substances to aid in the immune response, but the release of excessive amounts of these substances causes damage to one or more organs, most commonly the heart, skin, lungs, or nervous system. Eosinophil-associated organ damage can lead to a heart condition known as eosinophilic endomyocardial disease, skin rashes, coughing, difficulty breathing, swelling (edema) in the lower limbs, confusion, changes in behavior, or impaired movement or sensations. People with PDGFRA-associated chronic eosinophilic leukemia can also have an enlarged spleen (splenomegaly) and elevated levels of certain chemicals called vitamin B12 and tryptase in the blood.\n\nSome people with PDGFRA-associated chronic eosinophilic leukemia have an increased number of other types of white blood cells, such as neutrophils or mast cells. Occasionally, people with PDGFRA-associated chronic eosinophilic leukemia develop other blood cell cancers, such as acute myeloid leukemia or B-cell or T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma.\n\nPDGFRA-associated chronic eosinophilic leukemia is often grouped with a related condition called hypereosinophilic syndrome. These two conditions have very similar signs and symptoms; however, the cause of hypereosinophilic syndrome is unknown.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/61525">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_316944"><div><strong>Dilated cardiomyopathy 1C</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>316944</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1832244</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">An autosomal dominant subtype of dilated cardiomyopathy caused by mutation(s) in the LDB3 gene, encoding LIM domain-binding protein 3.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/316944">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_324806"><div><strong>Hypertrophic cardiomyopathy 8</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>324806</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1837471</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Any hypertrophic cardiomyopathy in which the cause of the disease is a mutation in the MYL3 gene.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/324806">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_344659"><div><strong>Hepatic veno-occlusive disease-immunodeficiency syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>344659</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1856128</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Hepatic veno-occlusive disease with immunodeficiency (VODI) is characterized by (1) combined immunodeficiency and (2) terminal hepatic lobular vascular occlusion and hepatic fibrosis manifesting as hepatomegaly and/or hepatic failure. Onset is usually before age six months. The immunodeficiency comprises severe hypogammaglobulinemia, clinical evidence of T-cell immunodeficiency with normal numbers of circulating T and B cells, absent lymph node germinal centers, and absent tissue plasma cells. Bacterial and opportunistic infections including Pneumocystis jirovecii infection, mucocutaneous candidiasis, and enteroviral or cytomegalovirus infections occur. In the past the prognosis for affected individuals was poor, with 100% mortality in the first year of life if unrecognized and untreated with intravenous or subcutaneous immunoglobulin (IVIG/SCIG) and Pneumocystis jirovecii prophylaxis. However, with early recognition and treatment, including the more recent use of defibrotide, there is a marked improvement in prognosis. Early hematopoietic stem cell transplantation (HSCT) using non-hepatoxic drugs in conditioning and prophylactic defibrotide is potentially curative.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/344659">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_393713"><div><strong>Dilated cardiomyopathy 1AA</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>393713</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C2677338</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Any familial isolated dilated cardiomyopathy in which the cause of the disease is a mutation in the ACTN2 gene.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/393713">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_413312"><div><strong>Hypertrophic cardiomyopathy 15</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>413312</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C2750459</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Any hypertrophic cardiomyopathy in which the cause of the disease is a mutation in the VCL gene.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/413312">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_393713" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Dilated cardiomyopathy 1AA</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_316944" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Dilated cardiomyopathy 1C</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_344659" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hepatic veno-occlusive disease-immunodeficiency syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_413312" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypertrophic cardiomyopathy 15</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_324806" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypertrophic cardiomyopathy 8</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_61525" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Idiopathic hypereosinophilic syndrome</a></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/27886792">Diagnosis and Management of Endomyocardial Fibrosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Beaton A,
Mocumbi AO</span><br />
<span class="medgenPMjournal">Cardiol Clin</span>
2017 Feb;35(1):87-98.
doi: 10.1016/j.ccl.2016.08.005.
<span class="bold">PMID: </span><a href="/pubmed/27886792" target="_blank">27886792</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26637706">Eosinophilia: a pragmatic approach to diagnosis and treatment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Klion AD</span><br />
<span class="medgenPMjournal">Hematology Am Soc Hematol Educ Program</span>
2015;2015:92-7.
doi: 10.1182/asheducation-2015.1.92.
<span class="bold">PMID: </span><a href="/pubmed/26637706" target="_blank">26637706</a></div>
<div class="nl"><a target="_blank" href="/pubmed/14214809">CLASSIFICATION AND DIFFERENTIAL DIAGNOSIS OF THE MYOCARDIOPATHIES.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">FOWLER NO</span><br />
<span class="medgenPMjournal">Prog Cardiovasc Dis</span>
1964 Jul;7:1-16.
doi: 10.1016/s0033-0620(64)80027-x.
<span class="bold">PMID: </span><a href="/pubmed/14214809" target="_blank">14214809</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22endomyocardial%20fibrosis%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (15)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/36485140">Approach to the patient with suspected hypereosinophilic syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Klion AD</span><br />
<span class="medgenPMjournal">Hematology Am Soc Hematol Educ Program</span>
2022 Dec 9;2022(1):47-54.
doi: 10.1182/hematology.2022000367.
<span class="bold">PMID: </span><a href="/pubmed/36485140" target="_blank">36485140</a><a href="/pmc/articles/PMC9821533" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36269634">Restrictive cardiomyopathy: definition and diagnosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Rapezzi C,
Aimo A,
Barison A,
Emdin M,
Porcari A,
Linhart A,
Keren A,
Merlo M,
Sinagra G</span><br />
<span class="medgenPMjournal">Eur Heart J</span>
2022 Dec 1;43(45):4679-4693.
doi: 10.1093/eurheartj/ehac543.
<span class="bold">PMID: </span><a href="/pubmed/36269634" target="_blank">36269634</a><a href="/pmc/articles/PMC9712030" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35414858">Overview of Restrictive Cardiomyopathies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gowda SN,
Ali HJ,
Hussain I</span><br />
<span class="medgenPMjournal">Methodist Debakey Cardiovasc J</span>
2022;18(2):4-16.
Epub 2022 Mar 14
doi: 10.14797/mdcvj.1078.
<span class="bold">PMID: </span><a href="/pubmed/35414858" target="_blank">35414858</a><a href="/pmc/articles/PMC8932380" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28356194">Assessment of TRPM7 functions by drug-like small molecules.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chubanov V,
Ferioli S,
Gudermann T</span><br />
<span class="medgenPMjournal">Cell Calcium</span>
2017 Nov;67:166-173.
Epub 2017 Mar 14
doi: 10.1016/j.ceca.2017.03.004.
<span class="bold">PMID: </span><a href="/pubmed/28356194" target="_blank">28356194</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25344016">Chronic kidney disease and cardiovascular complications.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Di Lullo L,
House A,
Gorini A,
Santoboni A,
Russo D,
Ronco C</span><br />
<span class="medgenPMjournal">Heart Fail Rev</span>
2015 May;20(3):259-72.
doi: 10.1007/s10741-014-9460-9.
<span class="bold">PMID: </span><a href="/pubmed/25344016" target="_blank">25344016</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Endomyocardial%20fibrosis%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (322)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/35414858">Overview of Restrictive Cardiomyopathies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gowda SN,
Ali HJ,
Hussain I</span><br />
<span class="medgenPMjournal">Methodist Debakey Cardiovasc J</span>
2022;18(2):4-16.
Epub 2022 Mar 14
doi: 10.14797/mdcvj.1078.
<span class="bold">PMID: </span><a href="/pubmed/35414858" target="_blank">35414858</a><a href="/pmc/articles/PMC8932380" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30056242">Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Frangogiannis NG</span><br />
<span class="medgenPMjournal">Mol Aspects Med</span>
2019 Feb;65:70-99.
Epub 2018 Aug 2
doi: 10.1016/j.mam.2018.07.001.
<span class="bold">PMID: </span><a href="/pubmed/30056242" target="_blank">30056242</a></div>
<div class="nl"><a target="_blank" href="/pubmed/20466198">Endomyocardial fibrosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Pieroni M,
Marzo F,
Smaldone C,
Camporeale A,
Macchione A,
Bellocci F,
Crea F</span><br />
<span class="medgenPMjournal">J Am Coll Cardiol</span>
2010 May 18;55(20):e137.
doi: 10.1016/j.jacc.2009.06.072.
<span class="bold">PMID: </span><a href="/pubmed/20466198" target="_blank">20466198</a></div>
<div class="nl"><a target="_blank" href="/pubmed/8995091">Restrictive cardiomyopathy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kushwaha SS,
Fallon JT,
Fuster V</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
1997 Jan 23;336(4):267-76.
doi: 10.1056/NEJM199701233360407.
<span class="bold">PMID: </span><a href="/pubmed/8995091" target="_blank">8995091</a></div>
<div class="nl"><a target="_blank" href="/pubmed/8049592">Restrictive cardiomyopathies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Spyrou N,
Foale R</span><br />
<span class="medgenPMjournal">Curr Opin Cardiol</span>
1994 May;9(3):344-8.
doi: 10.1097/00001573-199405000-00013.
<span class="bold">PMID: </span><a href="/pubmed/8049592" target="_blank">8049592</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Endomyocardial%20fibrosis%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (575)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/36485140">Approach to the patient with suspected hypereosinophilic syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Klion AD</span><br />
<span class="medgenPMjournal">Hematology Am Soc Hematol Educ Program</span>
2022 Dec 9;2022(1):47-54.
doi: 10.1182/hematology.2022000367.
<span class="bold">PMID: </span><a href="/pubmed/36485140" target="_blank">36485140</a><a href="/pmc/articles/PMC9821533" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34359886">Cardiac Fibrosis and Fibroblasts.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kurose H</span><br />
<span class="medgenPMjournal">Cells</span>
2021 Jul 6;10(7)
doi: 10.3390/cells10071716.
<span class="bold">PMID: </span><a href="/pubmed/34359886" target="_blank">34359886</a><a href="/pmc/articles/PMC8306806" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33361829">RADIOTHERAPY-ASSOCIATED CARDIOVASCULAR COMPLICATIONS IN CANCER (review).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kozhukhov SM,
Bazyka OY,
Dovganych NV,
Yarynkina OA,
Tkhor NV</span><br />
<span class="medgenPMjournal">Probl Radiac Med Radiobiol</span>
2020 Dec;25:56-74.
doi: 10.33145/2304-8336-2020-25-56-74.
<span class="bold">PMID: </span><a href="/pubmed/33361829" target="_blank">33361829</a></div>
<div class="nl"><a target="_blank" href="/pubmed/20869645">Restrictive cardiomyopathy in childhood.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Denfield SW,
Webber SA</span><br />
<span class="medgenPMjournal">Heart Fail Clin</span>
2010 Oct;6(4):445-52, viii.
doi: 10.1016/j.hfc.2010.05.005.
<span class="bold">PMID: </span><a href="/pubmed/20869645" target="_blank">20869645</a></div>
<div class="nl"><a target="_blank" href="/pubmed/17660828">Endothelial-to-mesenchymal transition contributes to cardiac fibrosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zeisberg EM,
Tarnavski O,
Zeisberg M,
Dorfman AL,
McMullen JR,
Gustafsson E,
Chandraker A,
Yuan X,
Pu WT,
Roberts AB,
Neilson EG,
Sayegh MH,
Izumo S,
Kalluri R</span><br />
<span class="medgenPMjournal">Nat Med</span>
2007 Aug;13(8):952-61.
Epub 2007 Jul 29
doi: 10.1038/nm1613.
<span class="bold">PMID: </span><a href="/pubmed/17660828" target="_blank">17660828</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Endomyocardial%20fibrosis%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (216)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/36485140">Approach to the patient with suspected hypereosinophilic syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Klion AD</span><br />
<span class="medgenPMjournal">Hematology Am Soc Hematol Educ Program</span>
2022 Dec 9;2022(1):47-54.
doi: 10.1182/hematology.2022000367.
<span class="bold">PMID: </span><a href="/pubmed/36485140" target="_blank">36485140</a><a href="/pmc/articles/PMC9821533" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32978708">Cardiac magnetic resonance in arrhythmogenic cardiomyopathies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Palumbo P,
Cannizzaro E,
Di Cesare A,
Bruno F,
Schicchi N,
Giovagnoni A,
Splendiani A,
Barile A,
Masciocchi C,
Di Cesare E</span><br />
<span class="medgenPMjournal">Radiol Med</span>
2020 Nov;125(11):1087-1101.
Epub 2020 Sep 25
doi: 10.1007/s11547-020-01289-6.
<span class="bold">PMID: </span><a href="/pubmed/32978708" target="_blank">32978708</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21744710">Endomyocardial fibrosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Vermeulen T,
Conraads VM,
Vrints CJ,
Paelinck BP</span><br />
<span class="medgenPMjournal">Acta Cardiol</span>
2011 Jun;66(3):375-7.
doi: 10.2143/AC.66.3.2114140.
<span class="bold">PMID: </span><a href="/pubmed/21744710" target="_blank">21744710</a></div>
<div class="nl"><a target="_blank" href="/pubmed/20869645">Restrictive cardiomyopathy in childhood.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Denfield SW,
Webber SA</span><br />
<span class="medgenPMjournal">Heart Fail Clin</span>
2010 Oct;6(4):445-52, viii.
doi: 10.1016/j.hfc.2010.05.005.
<span class="bold">PMID: </span><a href="/pubmed/20869645" target="_blank">20869645</a></div>
<div class="nl"><a target="_blank" href="/pubmed/8049592">Restrictive cardiomyopathies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Spyrou N,
Foale R</span><br />
<span class="medgenPMjournal">Curr Opin Cardiol</span>
1994 May;9(3):344-8.
doi: 10.1097/00001573-199405000-00013.
<span class="bold">PMID: </span><a href="/pubmed/8049592" target="_blank">8049592</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Endomyocardial%20fibrosis%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (296)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/31511695">Targeting cardiac fibrosis with engineered T cells.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Aghajanian H,
Kimura T,
Rurik JG,
Hancock AS,
Leibowitz MS,
Li L,
Scholler J,
Monslow J,
Lo A,
Han W,
Wang T,
Bedi K,
Morley MP,
Linares Saldana RA,
Bolar NA,
McDaid K,
Assenmacher CA,
Smith CL,
Wirth D,
June CH,
Margulies KB,
Jain R,
Puré E,
Albelda SM,
Epstein JA</span><br />
<span class="medgenPMjournal">Nature</span>
2019 Sep;573(7774):430-433.
Epub 2019 Sep 11
doi: 10.1038/s41586-019-1546-z.
<span class="bold">PMID: </span><a href="/pubmed/31511695" target="_blank">31511695</a><a href="/pmc/articles/PMC6752964" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27743952">The Many Faces of EMF.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">ElGuindy A,
Afifi A,
Simry W,
Romeih S,
Yacoub M</span><br />
<span class="medgenPMjournal">JACC Cardiovasc Imaging</span>
2017 Sep;10(9):1072-1075.
Epub 2016 Oct 12
doi: 10.1016/j.jcmg.2016.05.018.
<span class="bold">PMID: </span><a href="/pubmed/27743952" target="_blank">27743952</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26198161">Risk Stratification in Patients With Aortic Stenosis Using Novel Imaging Approaches.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chin CW,
Pawade TA,
Newby DE,
Dweck MR</span><br />
<span class="medgenPMjournal">Circ Cardiovasc Imaging</span>
2015 Aug;8(8):e003421.
doi: 10.1161/CIRCIMAGING.115.003421.
<span class="bold">PMID: </span><a href="/pubmed/26198161" target="_blank">26198161</a><a href="/pmc/articles/PMC4539578" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22935263">Cardiac mass in Behçet's disease.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Yue C,
Li J,
Li M,
Zhang F,
Zhao D,
Cui Q</span><br />
<span class="medgenPMjournal">Clin Exp Rheumatol</span>
2012 May-Jun;30(3 Suppl 72):S27-31.
Epub 2012 Sep 25
<span class="bold">PMID: </span><a href="/pubmed/22935263" target="_blank">22935263</a></div>
<div class="nl"><a target="_blank" href="/pubmed/8516501">Structural causes of cardiac dysfunction in uremia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Rambausek M,
Amann K,
Mall G,
Ritz E</span><br />
<span class="medgenPMjournal">Ren Fail</span>
1993;15(3):421-8.
doi: 10.3109/08860229309054955.
<span class="bold">PMID: </span><a href="/pubmed/8516501" target="_blank">8516501</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Endomyocardial%20fibrosis%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (206)</a></div></div>
</div>
<div class="portlet mgSection" id="ID_104">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/35590001">Imaging patterns of cerebral ischemia in hypereosinophilic syndrome: case report and systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Miethe K,
Iordanishvili E,
Habib P,
Panse J,
Krämer S,
Wiesmann M,
Schulz JB,
Nikoubashman O,
Reich A,
Pinho J</span><br />
<span class="medgenPMjournal">Neurol Sci</span>
2022 Aug;43(8):5091-5094.
Epub 2022 May 19
doi: 10.1007/s10072-022-06134-4.
<span class="bold">PMID: </span><a href="/pubmed/35590001" target="_blank">35590001</a><a href="/pmc/articles/PMC9349058" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33418479">Endomyocardiofibrosis: A Systematic Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Scatularo CE,
Posada Martínez EL,
Saldarriaga C,
Ballesteros OA,
Baranchuk A,
Sosa Liprandi A,
Wyss F,
Sosa Liprandi MI</span><br />
<span class="medgenPMjournal">Curr Probl Cardiol</span>
2021 Apr;46(4):100784.
Epub 2020 Dec 26
doi: 10.1016/j.cpcardiol.2020.100784.
<span class="bold">PMID: </span><a href="/pubmed/33418479" target="_blank">33418479</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31605544">The use of aliskiren as an antifibrotic drug in experimental models: A systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Altarejo Marin T,
Machado Bertassoli B,
Alves de Siqueira de Carvalho A,
Feder D</span><br />
<span class="medgenPMjournal">Drug Dev Res</span>
2020 Feb;81(1):114-126.
Epub 2019 Oct 12
doi: 10.1002/ddr.21610.
<span class="bold">PMID: </span><a href="/pubmed/31605544" target="_blank">31605544</a></div>
<div class="nl"><a target="_blank" href="/pubmed/18301727">Endomyocardial fibrosis: still a mystery after 60 years.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bukhman G,
Ziegler J,
Parry E</span><br />
<span class="medgenPMjournal">PLoS Negl Trop Dis</span>
2008 Feb 27;2(2):e97.
doi: 10.1371/journal.pntd.0000097.
<span class="bold">PMID: </span><a href="/pubmed/18301727" target="_blank">18301727</a><a href="/pmc/articles/PMC2254164" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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