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918 lines
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<!--
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UID=105458
|
||
ConceptID=C0520736
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Coombs-positive hemolytic anemia</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>105458</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0520736</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Direct Coombs positive</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Coombs positive hemolytic anemia (74789008)</td></tr>
|
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<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0004844">HP:0004844</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">A type of hemolytic anemia in which the Coombs test is positive. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Coombs-positive hemolytic anemia</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/163092" ref="tree=MeSH" title="MedGen record for Abnormality of blood and blood-forming tissues">Abnormality of blood and blood-forming tissues</a></span><ul><li><span class="TLline"><a href="/medgen/488883" ref="tree=MeSH" title="MedGen record for Abnormal erythrocyte morphology">Abnormal erythrocyte morphology</a></span><ul><li><span class="TLline"><a href="/medgen/1526" ref="tree=MeSH" title="MedGen record for Anemia">Anemia</a></span><ul><li><span class="TLline"><a href="/medgen/1916" ref="tree=MeSH" title="MedGen record for Hemolytic anemia">Hemolytic anemia</a></span><ul><li><span class="matched_ds">Coombs-positive hemolytic anemia</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
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||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_83339"><div><strong>Insulin-dependent diabetes mellitus secretory diarrhea syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>83339</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0342288</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked) syndrome is characterized by systemic autoimmunity, typically beginning in the first year of life, which includes the triad of enteropathy (manifesting as malabsorption and watery diarrhea), endocrinopathy (most commonly type 1 insulin-dependent diabetes mellitus), and eczematous dermatitis. In addition to these manifestations, many children have other autoimmune phenomena including cytopenias, autoimmune hepatitis, nephropathy, lymphadenopathy, splenomegaly, alopecia, arthritis, and interstitial lung disease related to immune dysregulation. Fetal presentation of IPEX syndrome includes hydrops, echogenic bowel, skin desquamation, intrauterine growth deficiency, and fetal akinesia. Without aggressive immunosuppression or hematopoietic stem cell transplantation (HSCT), the majority of affected males will die within the first one to two years of life from metabolic derangements, severe malabsorption, or sepsis. Individuals with a milder phenotype have survived into the second or third decade of life, but this is uncommon.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/83339">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_231300"><div><strong>Autoimmune lymphoproliferative syndrome type 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>231300</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1328840</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autoimmune lymphoproliferative syndrome (ALPS), caused by defective lymphocyte homeostasis, is characterized by the following: Non-malignant lymphoproliferation (lymphadenopathy, hepatosplenomegaly with or without hypersplenism) that often improves with age. Autoimmune disease, mostly directed toward blood cells. Lifelong increased risk for both Hodgkin and non-Hodgkin lymphoma. In ALPS-FAS (the most common and best-characterized type of ALPS, associated with heterozygous germline pathogenic variants in FAS), non-malignant lymphoproliferation typically manifests in the first years of life, inexplicably waxes and wanes, and then often decreases without treatment in the second decade of life; in many affected individuals, however, neither splenomegaly nor the overall expansion of lymphocyte subsets in peripheral blood decreases. Although autoimmunity is often not present at the time of diagnosis or at the time of the most extensive lymphoproliferation, autoantibodies can be detected before autoimmune disease manifests clinically. In ALPS-FAS caused by homozygous or compound heterozygous (biallelic) pathogenic variants in FAS, severe lymphoproliferation occurs before, at, or shortly after birth, and usually results in death at an early age. ALPS-sFAS, resulting from somatic FAS pathogenic variants in selected cell populations, notably the alpha/beta double-negative T cells (a/ß-DNT cells), appears to be similar to ALPS-FAS resulting from heterozygous germline pathogenic variants in FAS, although lower incidence of splenectomy and lower lymphocyte counts have been reported in ALPS-sFAS and no cases of lymphoma have yet been published.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/231300">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_333882"><div><strong>Heme oxygenase 1 deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>333882</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1841651</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Heme oxygenase-1 deficiency (HMOX1D) is a rare autosomal recessive disorder with a complex clinical presentation including direct antibody negative hemolytic anemia, low bilirubin, and hyperinflammation (summary by Chau et al., 2020). Other features may include asplenia and nephritis (Radhakrishnan et al., 2011).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/333882">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_349065"><div><strong>Autoimmune lymphoproliferative syndrome type 2A</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>349065</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1858968</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autoimmune lymphoproliferative syndrome (ALPS), caused by defective lymphocyte homeostasis, is characterized by the following: Non-malignant lymphoproliferation (lymphadenopathy, hepatosplenomegaly with or without hypersplenism) that often improves with age. Autoimmune disease, mostly directed toward blood cells. Lifelong increased risk for both Hodgkin and non-Hodgkin lymphoma. In ALPS-FAS (the most common and best-characterized type of ALPS, associated with heterozygous germline pathogenic variants in FAS), non-malignant lymphoproliferation typically manifests in the first years of life, inexplicably waxes and wanes, and then often decreases without treatment in the second decade of life; in many affected individuals, however, neither splenomegaly nor the overall expansion of lymphocyte subsets in peripheral blood decreases. Although autoimmunity is often not present at the time of diagnosis or at the time of the most extensive lymphoproliferation, autoantibodies can be detected before autoimmune disease manifests clinically. In ALPS-FAS caused by homozygous or compound heterozygous (biallelic) pathogenic variants in FAS, severe lymphoproliferation occurs before, at, or shortly after birth, and usually results in death at an early age. ALPS-sFAS, resulting from somatic FAS pathogenic variants in selected cell populations, notably the alpha/beta double-negative T cells (a/ß-DNT cells), appears to be similar to ALPS-FAS resulting from heterozygous germline pathogenic variants in FAS, although lower incidence of splenectomy and lower lymphocyte counts have been reported in ALPS-sFAS and no cases of lymphoma have yet been published.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/349065">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_355764"><div><strong>Spastic paraplegia and Evans syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>355764</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1866619</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/355764">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_816383"><div><strong>Combined immunodeficiency due to OX40 deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>816383</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3810053</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Immunodeficiency-16 (IMD16) is an autosomal recessive primary immunodeficiency associated with classic Kaposi sarcoma of childhood and poor T-cell recall immune responses due to complete functional OX40 deficiency (Byun et al., 2013).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/816383">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1384124"><div><strong>Severe combined immunodeficiency due to LAT deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1384124</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4479588</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">IMD52 is an autosomal recessive primary immunodeficiency with variable manifestations, including severe combined immunodeficiency, hematologic autoimmune disorders, progressive lymphopenia and hypogammaglobulinemia, and lymphoproliferation with splenomegaly. Patients develop severe recurrent infections from infancy, and most die without bone marrow transplantation. The variable clinical features result from a defect in T-cell receptor signaling (summary by Keller et al., 2016 and Bacchelli et al., 2017).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1384124">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1784363"><div><strong>Autoinflammatory syndrome with immunodeficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1784363</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5543547</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial autoinflammatory syndrome with or without immunodeficiency (AISIMD) is characterized by onset of various autoimmune features usually in the first decades of life, although later onset has been reported. Typical features include autoimmune cytopenia, hemolytic anemia, thrombocytopenia, and lymphadenopathy. More variable features may include autoimmune thyroiditis, psoriasis or eczema, nephritis, hepatitis, and symptoms of systemic lupus erythematosus (SLE; see 152700). Some patients may have recurrent infections or exacerbation of the disease with acute infection. Laboratory studies show variable findings, often decreased numbers of naive B cells, lymphopenia with skewed subsets, hypogammaglobulinemia, presence of autoantibodies, and a hyperinflammatory state. The disorder shows autosomal dominant inheritance with incomplete penetrance (summary by Hadjadj et al., 2020).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1784363">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1840213"><div><strong>Autoinflammatory disease, multisystem, with immune dysregulation, X-linked</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1840213</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5829577</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">X-linked multisystem autoinflammatory disease with immune dysregulation (ADMIDX) is an X-linked recessive disorder with onset of symptoms in infancy or early childhood. Affected individuals may present with variable cytopenias, including anemia, thrombocytopenia, neutropenia, lymphopenia, or hypogammaglobulinemia, and systemic or organ-specific autoinflammatory manifestations. These include skin lesions, panniculitis, inflammatory bowel disease, pulmonary disease, or arthritis associated with recurrent fever, leukocytosis, lymphoproliferation, and hepatosplenomegaly in the absence of an infectious agent. Some patients have circulating autoantibodies that underlie the cytopenias or systemic features, whereas others do not have circulating autoantibodies. In addition, some patients have recurrent infections, whereas others do not show signs of an immunodeficiency. Laboratory studies are consistent with immune dysregulation, including altered B-cell subsets and variably elevated proinflammatory cytokines. Detailed functional studies of platelets, red cells, and T lymphocytes suggest that abnormal actin cytoskeleton remodeling is a basic defect, indicating that this disorder can be classified as an immune-related actinopathy. Severe complications of the disease may result in death in childhood (Boussard et al., 2023; Block et al., 2023).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1840213">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_231300" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autoimmune lymphoproliferative syndrome type 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_349065" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autoimmune lymphoproliferative syndrome type 2A</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1840213" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autoinflammatory disease, multisystem, with immune dysregulation, X-linked</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1784363" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autoinflammatory syndrome with immunodeficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_816383" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Combined immunodeficiency due to OX40 deficiency</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (9)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_333882" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Heme oxygenase 1 deficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_83339" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Insulin-dependent diabetes mellitus secretory diarrhea syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1384124" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Severe combined immunodeficiency due to LAT deficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_355764" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Spastic paraplegia and Evans syndrome</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35282954">Updates on the Diagnosis and Management of Cold Autoimmune Hemolytic Anemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gertz MA</span><br />
|
||
<span class="medgenPMjournal">Hematol Oncol Clin North Am</span>
|
||
2022 Apr;36(2):341-352.
|
||
Epub 2022 Mar 11
|
||
doi: 10.1016/j.hoc.2021.11.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35282954" target="_blank">35282954</a><a href="/pmc/articles/PMC9088174" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25201797">Anti-CD20 treatment of giant cell hepatitis with autoimmune hemolytic anemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Paganelli M,
|
||
Patey N,
|
||
Bass LM,
|
||
Alvarez F</span><br />
|
||
<span class="medgenPMjournal">Pediatrics</span>
|
||
2014 Oct;134(4):e1206-10.
|
||
Epub 2014 Sep 8
|
||
doi: 10.1542/peds.2014-0032.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25201797" target="_blank">25201797</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9339762">Treatment of severe Evans syndrome with an allogeneic cord blood transplant.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Raetz E,
|
||
Beatty PG,
|
||
Adams RH</span><br />
|
||
<span class="medgenPMjournal">Bone Marrow Transplant</span>
|
||
1997 Sep;20(5):427-9.
|
||
doi: 10.1038/sj.bmt.1700907.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9339762" target="_blank">9339762</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22coombs-positive%20hemolytic%20anemia%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (4)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34599046">Schizophrenia Genetics and Neuropsychiatric Features in Childhood-onset Systemic Lupus Erythematosus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ulloa AC,
|
||
Liao F,
|
||
Carlomagno RL,
|
||
Diaz T,
|
||
Dominguez D,
|
||
Levy DM,
|
||
Ng L,
|
||
Knight AM,
|
||
Hiraki LT</span><br />
|
||
<span class="medgenPMjournal">J Rheumatol</span>
|
||
2022 Feb;49(2):192-196.
|
||
Epub 2021 Oct 1
|
||
doi: 10.3899/jrheum.210363.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34599046" target="_blank">34599046</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16416207">A new mutation of Wilson's disease P-type ATPase gene in a patient with cirrhosis and coombs-positive hemolytic anemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Leggio L,
|
||
Addolorato G,
|
||
Loudianos G,
|
||
Abenavoli L,
|
||
Lepori MB,
|
||
Vecchio FM,
|
||
Rapaccini GL,
|
||
De Virgiliis S,
|
||
Gasbarrini G</span><br />
|
||
<span class="medgenPMjournal">Dig Dis Sci</span>
|
||
2006 Jan;51(1):34-8.
|
||
doi: 10.1007/s10620-006-3080-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16416207" target="_blank">16416207</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9382055">Autoimmune hemolytic anemia and positive Coombs test associated with ulcerative colitis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Giannadaki E,
|
||
Potamianos S,
|
||
Roussomoustakaki M,
|
||
Kyriakou D,
|
||
Fragkiadakis N,
|
||
Manousos ON</span><br />
|
||
<span class="medgenPMjournal">Am J Gastroenterol</span>
|
||
1997 Oct;92(10):1872-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9382055" target="_blank">9382055</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6606357">Immunoregulatory abnormalities in Evans syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang W,
|
||
Herrod H,
|
||
Pui CH,
|
||
Presbury G,
|
||
Wilimas J</span><br />
|
||
<span class="medgenPMjournal">Am J Hematol</span>
|
||
1983 Dec;15(4):381-90.
|
||
doi: 10.1002/ajh.2830150409.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6606357" target="_blank">6606357</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6967746">Studies on levamisole--induced agranulocytosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Thompson JS,
|
||
Herbick JM,
|
||
Klassen LW,
|
||
Severson CD,
|
||
Overlin VL,
|
||
Blaschke JW,
|
||
Silverman MA,
|
||
Vogel CL</span><br />
|
||
<span class="medgenPMjournal">Blood</span>
|
||
1980 Sep;56(3):388-96.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6967746" target="_blank">6967746</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Coombs-positive%20hemolytic%20anemia%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (19)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35282954">Updates on the Diagnosis and Management of Cold Autoimmune Hemolytic Anemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gertz MA</span><br />
|
||
<span class="medgenPMjournal">Hematol Oncol Clin North Am</span>
|
||
2022 Apr;36(2):341-352.
|
||
Epub 2022 Mar 11
|
||
doi: 10.1016/j.hoc.2021.11.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35282954" target="_blank">35282954</a><a href="/pmc/articles/PMC9088174" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16416207">A new mutation of Wilson's disease P-type ATPase gene in a patient with cirrhosis and coombs-positive hemolytic anemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Leggio L,
|
||
Addolorato G,
|
||
Loudianos G,
|
||
Abenavoli L,
|
||
Lepori MB,
|
||
Vecchio FM,
|
||
Rapaccini GL,
|
||
De Virgiliis S,
|
||
Gasbarrini G</span><br />
|
||
<span class="medgenPMjournal">Dig Dis Sci</span>
|
||
2006 Jan;51(1):34-8.
|
||
doi: 10.1007/s10620-006-3080-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16416207" target="_blank">16416207</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9110912">Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 13-1997. A 32-year-old man with IgG antibody and Coombs'-positive hemolytic anemia resistant to corticosteroid therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMjournal">N Engl J Med</span>
|
||
1997 Apr 24;336(17):1235-41.
|
||
doi: 10.1056/NEJM199704243361707.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9110912" target="_blank">9110912</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1160960">Letter: ESR and Coombs-positive hemolytic anemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ballas SK</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
1975 Oct 9;293(15):776-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1160960" target="_blank">1160960</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/4700414">Chronic active hepatitis associated with eosinophilia and Coombs'-positive hemolytic anemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Panush RS,
|
||
Wilkinson LS,
|
||
Fagin RR</span><br />
|
||
<span class="medgenPMjournal">Gastroenterology</span>
|
||
1973 May;64(5):1015-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/4700414" target="_blank">4700414</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Coombs-positive%20hemolytic%20anemia%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (43)</a></div><h3 class="subhead">Therapy</h3>
|
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<div class="nl"><a target="_blank" href="/pubmed/35282954">Updates on the Diagnosis and Management of Cold Autoimmune Hemolytic Anemia.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Gertz MA</span><br />
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<span class="medgenPMjournal">Hematol Oncol Clin North Am</span>
|
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2022 Apr;36(2):341-352.
|
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Epub 2022 Mar 11
|
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doi: 10.1016/j.hoc.2021.11.001.
|
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<span class="bold">PMID: </span><a href="/pubmed/35282954" target="_blank">35282954</a><a href="/pmc/articles/PMC9088174" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/5129550">Scleroderma associated with thrombocytopenia and Coombs-positive hemolytic anemia.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Ivey KJ,
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<div class="nl"><a target="_blank" href="/pubmed/5805237">Coombs' positive hemolytic anemia in myelofibrosis with myeloid metaplasia.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Khumbanonda M,
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<div class="nl"><a target="_blank" href="/pubmed/6016540">Coombs'-positive hemolytic anemia in Hodgkin's disease.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Eisner E,
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<span class="bold">PMID: </span><a href="/pubmed/6016540" target="_blank">6016540</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/4159252">Coombs-positive hemolytic anemia caused by penicillin administration.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Petz LD,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Coombs-positive%20hemolytic%20anemia%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (56)</a></div><h3 class="subhead">Prognosis</h3>
|
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<div class="nl"><a target="_blank" href="/pubmed/16416207">A new mutation of Wilson's disease P-type ATPase gene in a patient with cirrhosis and coombs-positive hemolytic anemia.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Leggio L,
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Addolorato G,
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Loudianos G,
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<div class="nl"><a target="_blank" href="/pubmed/16176422">Successful liver transplantation for giant cell hepatitis and Coombs-positive hemolytic anemia: a case report.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Akyildiz M,
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Karasu Z,
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Arikan C,
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<span class="bold">PMID: </span><a href="/pubmed/16176422" target="_blank">16176422</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/15297855">Chronic hepatitis C associated with Coombs-positive hemolytic anemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Elhajj II,
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<span class="bold">PMID: </span><a href="/pubmed/15297855" target="_blank">15297855</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/3758517">'Acute' autoimmune hepatitis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Crapper RM,
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Bhathal PS,
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Mackay IR,
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<span class="bold">PMID: </span><a href="/pubmed/3758517" target="_blank">3758517</a></div>
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||
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||
<div class="nl"><a target="_blank" href="/pubmed/1006330">Coombs--negative immune hemolytic anemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gilliland BC</span><br />
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<span class="medgenPMjournal">Semin Hematol</span>
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1976 Oct;13(4):267-75.
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||
<span class="bold">PMID: </span><a href="/pubmed/1006330" target="_blank">1006330</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Coombs-positive%20hemolytic%20anemia%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (32)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34599046">Schizophrenia Genetics and Neuropsychiatric Features in Childhood-onset Systemic Lupus Erythematosus.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Ulloa AC,
|
||
Liao F,
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||
Carlomagno RL,
|
||
Diaz T,
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Dominguez D,
|
||
Levy DM,
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||
Ng L,
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||
Knight AM,
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Hiraki LT</span><br />
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<span class="medgenPMjournal">J Rheumatol</span>
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||
2022 Feb;49(2):192-196.
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||
Epub 2021 Oct 1
|
||
doi: 10.3899/jrheum.210363.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34599046" target="_blank">34599046</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18372364">Systemic lupus erythematosus in the Fars Province of Iran.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nazarinia MA,
|
||
Ghaffarpasand F,
|
||
Shamsdin A,
|
||
Karimi AA,
|
||
Abbasi N,
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2008 Mar;17(3):221-7.
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|
||
<span class="bold">PMID: </span><a href="/pubmed/18372364" target="_blank">18372364</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15879729">Coombs-positive autoimmune hemolytic anemia in Crohn's disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Plikat K,
|
||
Rogler G,
|
||
Schölmerich J</span><br />
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<span class="medgenPMjournal">Eur J Gastroenterol Hepatol</span>
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||
2005 Jun;17(6):661-6.
|
||
doi: 10.1097/00042737-200506000-00011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15879729" target="_blank">15879729</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2527007">Captopril-associated acute interstitial nephritis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Smith WR,
|
||
Neill J,
|
||
Cushman WC,
|
||
Butkus DE</span><br />
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<span class="medgenPMjournal">Am J Nephrol</span>
|
||
1989;9(3):230-5.
|
||
doi: 10.1159/000167970.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2527007" target="_blank">2527007</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2445328">High dose intravenous gammaglobulin in Coombs positive hemolytic anemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mitchell CA,
|
||
Van der Weyden MB,
|
||
Firkin BG</span><br />
|
||
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1987 Jun;17(3):290-4.
|
||
doi: 10.1111/j.1445-5994.1987.tb01228.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2445328" target="_blank">2445328</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Coombs-positive%20hemolytic%20anemia%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (12)</a></div></div>
|
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|
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