669 lines
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669 lines
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<div class="res_logo"><h1 class="img_logo"><a href="/" title="NCBI home">NCBI</a></h1><h2 class="res_tagline">National Center for Biotechnology Information</h2></div>
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<div class="search"><form method="get" action="/gquery/"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="gquery" selected="selected" class="last">All Databases</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene">Gene</option><option value="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen">MedGen</option><option value="mesh">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search All Databases" value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="isEnabled:false,disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'no',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div></form></div>
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<h2>Genes & Expression</h2>
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<a href="#tab-all">All</a>
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<h3>Databases</h3>
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<dl>
|
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<dt class="featured">
|
||
<a href="/bioproject" title="">BioProject (formerly Genome Project)</a>
|
||
</dt>
|
||
<dd><p>
|
||
A collection of genomics, functional genomics, and genetics studies and links to their resulting datasets. This resource describes project scope, material, and objectives and provides a mechanism to retrieve datasets that are often difficult to find due to inconsistent annotation, multiple independent submissions, and the varied nature of diverse data types which are often stored in different databases.</p>
|
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</dd>
|
||
<dt>
|
||
<a href="/clinvar" title="">ClinVar</a>
|
||
</dt>
|
||
<dd><p>
|
||
A resource to provide a public, tracked record of reported relationships between human variation and observed health status with supporting evidence. Related information in the <a href="/gtr/">NIH Genetic Testing Registry (GTR)</a>, <a href="/medgen/">MedGen</a>, <a href="/gene">Gene</a>, <a href="http://www.omim.org">OMIM</a>, <a href="/pubmed/">PubMed</a> and other sources is accessible through hyperlinks on the records.</p>
|
||
</dd>
|
||
<dt>
|
||
<a href="/projects/CCDS/CcdsBrowse.cgi" title="">Consensus CDS (CCDS)</a>
|
||
</dt>
|
||
<dd><p>
|
||
A collaborative effort to identify a core set of human and mouse protein coding regions that are consistently annotated and of high quality.</p>
|
||
</dd>
|
||
<dt class="featured">
|
||
<a href="/gap" title="">Database of Genotypes and Phenotypes (dbGaP)</a>
|
||
</dt>
|
||
<dd><p>
|
||
An archive and distribution center for the description and results of studies which investigate the interaction of genotype and phenotype. These studies include genome-wide association (GWAS), medical resequencing, molecular diagnostic assays, as well as association between genotype and non-clinical traits. </p>
|
||
</dd>
|
||
<dt class="featured">
|
||
<a href="/gene" title="">Gene</a>
|
||
</dt>
|
||
<dd><p>
|
||
A searchable database of genes, focusing on genomes that have been completely sequenced and that have an active research community to contribute gene-specific data. Information includes nomenclature, chromosomal localization, gene products and their attributes (e.g., protein interactions), associated markers, phenotypes, interactions, and links to citations, sequences, variation details, maps, expression reports, homologs, protein domain content, and external databases.</p>
|
||
</dd>
|
||
<dt class="featured">
|
||
<a href="/geo/" title="">Gene Expression Omnibus (GEO) Database </a>
|
||
</dt>
|
||
<dd><p>
|
||
A public functional genomics data repository supporting MIAME-compliant data submissions. Array- and sequence-based data are accepted and tools are provided to help users query and download experiments and curated gene expression profiles.</p>
|
||
</dd>
|
||
<dt class="featured">
|
||
<a href="/gds" title="">Gene Expression Omnibus (GEO) Datasets</a>
|
||
</dt>
|
||
<dd><p>
|
||
Stores curated gene expression and molecular abundance DataSets assembled from the Gene Expression Omnibus (GEO) repository. DataSet records contain additional resources, including cluster tools and differential expression queries.</p>
|
||
</dd>
|
||
<dt class="featured">
|
||
<a href="/geoprofiles/" title="">Gene Expression Omnibus (GEO) Profiles</a>
|
||
</dt>
|
||
<dd><p>
|
||
Stores individual gene expression and molecular abundance Profiles assembled from the Gene Expression Omnibus (GEO) repository. Search for specific profiles of interest based on gene annotation or pre-computed profile characteristics.</p>
|
||
</dd>
|
||
<dt>
|
||
<a href="/books/NBK22183/" title="">Genes and Disease</a>
|
||
</dt>
|
||
<dd><p>
|
||
Summaries of information for selected genetic disorders with discussions of the underlying mutation(s) and clinical features, as well as links to related databases and organizations.</p>
|
||
</dd>
|
||
<dt>
|
||
<a href="/gtr/" title="">Genetic Testing Registry (GTR)</a>
|
||
</dt>
|
||
<dd><p>
|
||
A voluntary registry of genetic tests and laboratories, with detailed information about the tests such as what is measured and analytic and clinical validity. GTR also is a nexus for information about genetic conditions and provides context-specific links to a variety of resources, including practice guidelines, published literature, and genetic data/information. The initial scope of GTR includes single gene tests for Mendelian disorders, as well as arrays, panels and pharmacogenetic tests.</p>
|
||
</dd>
|
||
<dt class="featured">
|
||
<a href="/omim" title="">Online Mendelian Inheritance in Man (OMIM)</a>
|
||
</dt>
|
||
<dd><p>
|
||
A database of human genes and genetic disorders. NCBI maintains current content and continues to support its searching and integration with other NCBI databases. However, OMIM now has a new home at <a href="http://omim.org">omim.org</a>, and users are directed to this site for full record displays.</p>
|
||
</dd>
|
||
<dt class="featured">
|
||
<a href="/refseq/rsg/" title="">RefSeqGene</a>
|
||
</dt>
|
||
<dd>A collection of human gene-specific reference genomic sequences. RefSeq gene is a subset of NCBI’s RefSeq database, and are defined based on review from curators of locus-specific databases and the genetic testing community. They form a stable foundation for reporting mutations, for establishing consistent intron and exon numbering conventions, and for defining the coordinates of other biologically significant variation. RefSeqGene is a part of the Locus Reference Genomic (<a href="http://www.lrg-sequence.org/">LRG</a>) Collaboration.
|
||
</dd>
|
||
</dl>
|
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</div>
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<div id="downloads" class="tab-tabs">
|
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<h3>Downloads</h3>
|
||
<dl>
|
||
<dt>
|
||
<a href="https://ftp.ncbi.nlm.nih.gov/gene/" title="">FTP: Gene</a>
|
||
</dt>
|
||
<dd><p>
|
||
This site contains three directories: DATA, GeneRIF and tools. The DATA directory contains files listing all data linked to GeneIDs along with subdirectories containing ASN.1 data for the Gene records. The GeneRIF (Gene References into Function) directory contains PubMed identifiers for articles describing the function of a single gene or interactions between products of two genes. Sample programs for manipulating gene data are provided in the tools directory. Please see the README file for details.</p>
|
||
</dd>
|
||
<dt>
|
||
<a href="https://ftp.ncbi.nlm.nih.gov/pub/geo/" title="">FTP: Gene Expression Omnibus (GEO) Profiles and Datasets</a>
|
||
</dt>
|
||
<dd><p>
|
||
This site contains GEO data in two formats: SOFT (Simple Omnibus in Text Format) and MINiML (MIAME Notation in Markup Language). Summary text files and supplementary data are also available. Please see the README.TXT file for more information.</p>
|
||
</dd>
|
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</dl>
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</div>
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<div id="submissions" class="tab-tabs">
|
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<h3>Submissions</h3>
|
||
<dl>
|
||
<dt>
|
||
<a href="https://submit.ncbi.nlm.nih.gov/subs/bioproject/" title="">BioProject Submission</a>
|
||
</dt>
|
||
<dd><p>
|
||
An online form that provides an interface for researchers, consortia and organizations to register their BioProjects. This serves as the starting point for the submission of genomic and genetic data for the study. The data does not need to be submitted at the time of BioProject registration.</p>
|
||
</dd>
|
||
<dt>
|
||
<a href="/projects/gap/cgi-bin/about.cgi" title="">Database of Genotype and Phenotype (dbGaP) Data Submission Policies</a>
|
||
</dt>
|
||
<dd><p>
|
||
Guidelines and requirements for submitting genotype and phenotype association data to dbGaP.</p>
|
||
</dd>
|
||
<dt>
|
||
<a href="/projects/geo/info/submission.html" title="">Gene Expression Omnibus (GEO) Web Deposit</a>
|
||
</dt>
|
||
<dd><p>
|
||
Submit expression data, such as microarray, SAGE or mass spectrometry datasets to the NCBI Gene Expression Omnibus (GEO) database.</p>
|
||
</dd>
|
||
<dt>
|
||
<a href="/gene/about-generif" title="">GeneRIF</a>
|
||
</dt>
|
||
<dd><p>
|
||
GeneRIF provides a simple mechanism to allow scientists to add to the functional annotation of genes in the Gene database.</p>
|
||
</dd>
|
||
<dt>
|
||
<a href="https://submit.ncbi.nlm.nih.gov" title="">Submission Portal</a>
|
||
</dt>
|
||
<dd><p>
|
||
A single entry point for submitters to link to and find information about all of the data submission processes at NCBI. Currently, this serves as an interface for the registration of BioProjects and BioSamples and submission of data for WGS and GTR. Future additions to this site are planned.</p>
|
||
</dd>
|
||
</dl>
|
||
</div>
|
||
<div id="tools" class="tab-tabs">
|
||
<h3>Tools</h3>
|
||
<dl>
|
||
<dt>
|
||
<a href="https://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&BLAST_PROGRAMS=megaBlast&PAGE_TYPE=BlastSearch&SHOW_DEFAULTS=on&BLAST_SPEC=RefseqGene" title="">BLAST RefSeqGene</a>
|
||
</dt>
|
||
<dd><p>
|
||
Performs a BLAST search of the genomic sequences in the <a href="https://www.ncbi.nlm.nih.gov/refseq/rsg/">RefSeqGene</a>/LRG set. The default display provides ready navigation to review alignments in the Graphics display.</p>
|
||
</dd>
|
||
<dt class="featured">
|
||
<a href="/books/NBK25501/ " title="">E-Utilities</a>
|
||
</dt>
|
||
<dd><p>
|
||
Tools that provide access to data within NCBI's Entrez system outside of the regular web query interface. They provide a method of automating Entrez tasks within software applications. Each utility performs a specialized retrieval task, and can be used simply by writing a specially formatted URL.</p>
|
||
</dd>
|
||
<dt>
|
||
<a href="/geo/query/blast.html" title="">Gene Expression Omnibus (GEO) BLAST</a>
|
||
</dt>
|
||
<dd><p>
|
||
Tool for aligning a query sequence (nucleotide or protein) to GenBank sequences included on microarray or SAGE platforms in the GEO database.</p>
|
||
</dd>
|
||
<dt>
|
||
<a href="/gap/PheGenI " title="">Phenotype-Genotype Integrator (PheGenI) </a>
|
||
</dt>
|
||
<dd><p>
|
||
Supports finding human phenotype/genotype relationships with queries by phenotype, chromosome location, gene, and SNP identifiers. Currently includes information from dbGaP, the NHGRI GWAS Catalog, and GTeX. Displays results on the genome, on sequence, or in tables for download.</p>
|
||
</dd>
|
||
<dt>
|
||
<a href="/projects/sviewer/" title="">Sequence Viewer</a>
|
||
</dt>
|
||
<dd><p>
|
||
Provides a configurable graphical display of a nucleotide or protein sequence and features that have been annotated on that sequence. In addition to use on NCBI sequence database pages, this viewer is available as an embeddable webpage component. <a href="/projects/sviewer/embedded.html">Detailed documentation</a> including an API Reference guide is available for developers wishing to embed the viewer in their own pages.</p>
|
||
</dd>
|
||
</dl>
|
||
</div>
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<div id="howtos" class="tab-tabs">
|
||
<h3>How To</h3>
|
||
<ul>
|
||
<li>
|
||
<a href="/guide/howto/receive-search-results">Save text searches and set up automated searches with E-mailed results</a>
|
||
</li>
|
||
<li>
|
||
<a href="/guide/howto/submit-data">Submit data to NCBI</a>
|
||
</li>
|
||
<li>
|
||
<a href="/guide/howto/find-func-gene">Find the function of a gene or gene product</a>
|
||
</li>
|
||
<li>
|
||
<a href="/guide/howto/find-gen-phen">Find genes associated with a phenotype or disease</a>
|
||
</li>
|
||
<li>
|
||
<a href="/guide/howto/find-exp-pat">Find expression patterns</a>
|
||
</li>
|
||
<li>
|
||
<a href="/guide/howto/find-homolog-gene">Find a homolog for a gene in another organism</a>
|
||
</li>
|
||
<li>
|
||
<a href="/guide/howto/find-published-info-gene-sequence">Find published information on a gene or sequence</a>
|
||
</li>
|
||
<li>
|
||
<a href="/guide/howto/find-transcript-gene">Find transcript sequences for a gene</a>
|
||
</li>
|
||
<li>
|
||
<a href="/guide/howto/compare-to-refseqgene">Compare your sequence to the RefSeqGene/LRG standard</a>
|
||
</li>
|
||
<li>
|
||
<a href="/guide/howto/view-gen-freq">View genotype frequency data for a gene, disease or short genetic variation</a>
|
||
</li>
|
||
<li>
|
||
<a href="/guide/howto/dwn-records">Download a large, custom set of records from NCBI</a>
|
||
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|
||
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|
||
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|
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|
||
<a href="/bioproject">BioProject (formerly Genome Project)</a>
|
||
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|
||
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|
||
<a href="/gap">Database of Genotypes and Phenotypes (dbGaP)</a>
|
||
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|
||
<li>
|
||
<a href="/gene">Gene</a>
|
||
</li>
|
||
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|
||
<a href="/geo/">Gene Expression Omnibus (GEO) Database </a>
|
||
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|
||
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|
||
<a href="/gds">Gene Expression Omnibus (GEO) Datasets</a>
|
||
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|
||
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|
||
<a href="/geoprofiles/">Gene Expression Omnibus (GEO) Profiles</a>
|
||
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|
||
<li>
|
||
<a href="/omim">Online Mendelian Inheritance in Man (OMIM)</a>
|
||
</li>
|
||
<li>
|
||
<a href="/refseq/rsg/">RefSeqGene</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK25501/ ">E-Utilities</a>
|
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<li class="list-inline-item"><a href="https://www.youtube.com/user/NLMNIH" aria-label="Youtube" target="_blank" rel="noopener noreferrer">
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|
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<p class="address_footer text-white">National Library of Medicine<br />
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<a href="https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/@38.9959508,-77.101021,17z/data=!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb:0x19156f88b27635b8!8m2!3d38.9959508!4d-77.0988323" class="text-white" target="_blank" rel="noopener noreferrer">8600 Rockville Pike<br />
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||
Bethesda, MD 20894</a></p>
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<div class="col-lg-3 col-12 centered-lg">
|
||
<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
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||
<a href="https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office" class="text-white">FOIA</a><br />
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||
<a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" class="text-white" id="vdp">HHS Vulnerability Disclosure</a></p>
|
||
</div>
|
||
<div class="col-lg-3 col-12 centered-lg">
|
||
<p><a class="supportLink text-white" href="https://support.nlm.nih.gov/">Help</a><br />
|
||
<a href="https://www.nlm.nih.gov/accessibility.html" class="text-white">Accessibility</a><br />
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||
<a href="https://www.nlm.nih.gov/careers/careers.html" class="text-white">Careers</a></p>
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<a class="text-white" href="//www.nlm.nih.gov/">NLM</a>
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||
<a class="text-white" href="https://www.nih.gov/">NIH</a>
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||
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|
||
<a class="text-white" href="https://www.hhs.gov/">HHS</a>
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<a class="text-white" href="https://www.usa.gov/">USA.gov</a>
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