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449 lines
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<div class="search_result"><div class="title_and_pager"><div class="pagination"><span class="inactive page_link"><< First</span><span class="inactive page_link prev">< Prev</span><h3 class="page">Page 1 of 60</h3><a href="https://www.ncbi.nlm.nih.gov/gtr/genes/?term=kinase&page=2" class="active page_link next" data-value="2">Next ></a><a href="https://www.ncbi.nlm.nih.gov/gtr/genes/?term=kinase&page=60" class="active page_link" data-value="60">Last >></a></div><div class="result_count_holder"><h2 class="result_count">Results: 1 to 20 of 1189</h2></div></div><div class="rprts"><div class="rprt"><div class="rprtnum">1.</div><div class="rslt"><p class="title"><a href="https://www.ncbi.nlm.nih.gov/gtr/genes/1956" ref="ncbi_uid=1956&link_uid=1956">EGFR</a><span class="no_uline"> - epidermal growth factor receptor</span></p><div class="supp"><p class="details">The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein <b>kinase</b> superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020]</p><div class="details"><dl><dt><strong>Also known as: </strong></dt><dd>ERBB, ERBB1, ERRP, HER1, NISBD2, NNCIS, PIG61, mENA</dd></dl><dl><dt><strong>Chromosome: </strong></dt><dd>7; </dd><dt><strong>Location: </strong></dt><dd>7p11.2</dd></dl></div></div><div class="aux"><ul class="db_links"><li><a href="/gene/1956/" target="_blank">More about this gene</a></li></ul></div></div></div><div class="rprt"><div class="rprtnum">2.</div><div class="rslt"><p class="title"><a href="https://www.ncbi.nlm.nih.gov/gtr/genes/2064" ref="ncbi_uid=2064&link_uid=2064">ERBB2</a><span class="no_uline"> - erb-b2 receptor tyrosine <b>kinase</b> 2</span></p><div class="supp"><p class="details">This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing <b>kinase</b>-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein <b>kinase</b> and phosphatidylinositol-3 <b>kinase</b>. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]</p><div class="details"><dl><dt><strong>Also known as: </strong></dt><dd>CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19, NEU, NGL, TKR1, VSCN2, c-ERB-2, c-ERB2, p185(erbB2)</dd></dl><dl><dt><strong>Chromosome: </strong></dt><dd>17; </dd><dt><strong>Location: </strong></dt><dd>17q12</dd></dl></div></div><div class="aux"><ul class="db_links"><li><a href="/gene/2064/" target="_blank">More about this gene</a></li></ul></div></div></div><div class="rprt"><div class="rprtnum">3.</div><div class="rslt"><p class="title"><a href="https://www.ncbi.nlm.nih.gov/gtr/genes/673" ref="ncbi_uid=673&link_uid=673">BRAF</a><span class="no_uline"> - B-Raf proto-oncogene, serine/threonine <b>kinase</b></span></p><div class="supp"><p class="details">This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP <b>kinase</b>/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]</p><div class="details"><dl><dt><strong>Also known as: </strong></dt><dd>B-RAF1, B-raf, BRAF-1, BRAF1, NS7, RAFB1</dd></dl><dl><dt><strong>Chromosome: </strong></dt><dd>7; </dd><dt><strong>Location: </strong></dt><dd>7q34</dd></dl></div></div><div class="aux"><ul class="db_links"><li><a href="/gene/673/" target="_blank">More about this gene</a></li></ul></div></div></div><div class="rprt"><div class="rprtnum">4.</div><div class="rslt"><p class="title"><a href="https://www.ncbi.nlm.nih.gov/gtr/genes/207" ref="ncbi_uid=207&link_uid=207">AKT1</a><span class="no_uline"> - AKT serine/threonine <b>kinase</b> 1</span></p><div class="supp"><p class="details">This gene encodes one of the three members of the human AKT serine-threonine protein <b>kinase</b> family which are often referred to as protein <b>kinase</b> B alpha, beta, and gamma. These highly similar AKT proteins all have an N-terminal pleckstrin homology domain, a serine/threonine-specific <b>kinase</b> domain and a C-terminal regulatory domain. These proteins are phosphorylated by phosphoinositide 3-<b>kinase</b> (PI3K). AKT/PI3K forms a key component of many signalling pathways that involve the binding of membrane-bound ligands such as receptor tyrosine kinases, G-protein coupled receptors, and integrin-linked <b>kinase</b>. These AKT proteins therefore regulate a wide variety of cellular functions including cell proliferation, survival, metabolism, and angiogenesis in both normal and malignant cells. AKT proteins are recruited to the cell membrane by phosphatidylinositol 3,4,5-trisphosphate (PIP3) after phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) by PI3K. Subsequent phosphorylation of both threonine residue 308 and serine residue 473 is required for full activation of the AKT1 protein encoded by this gene. Phosphorylation of additional residues also occurs, for example, in response to insulin growth factor-1 and epidermal growth factor. Protein phosphatases act as negative regulators of AKT proteins by dephosphorylating AKT or PIP3. The PI3K/AKT signalling pathway is crucial for tumor cell survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating AKT1 which then phosphorylates and inactivates components of the apoptotic machinery. AKT proteins also participate in the mammalian target of rapamycin (mTOR) signalling pathway which controls the assembly of the eukaryotic translation initiation factor 4F (eIF4E) complex and this pathway, in addition to responding to extracellular signals from growth factors and cytokines, is disregulated in many cancers. Mutations in this gene are associated with multiple types of cancer and excessive tissue growth including Proteus syndrome and Cowden syndrome 6, and breast, colorectal, and ovarian cancers. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2020]</p><div class="details"><dl><dt><strong>Also known as: </strong></dt><dd>AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA</dd></dl><dl><dt><strong>Chromosome: </strong></dt><dd>14; </dd><dt><strong>Location: </strong></dt><dd>14q32.33</dd></dl></div></div><div class="aux"><ul class="db_links"><li><a href="/gene/207/" target="_blank">More about this gene</a></li></ul></div></div></div><div class="rprt"><div class="rprtnum">5.</div><div class="rslt"><p class="title"><a href="https://www.ncbi.nlm.nih.gov/gtr/genes/1029" ref="ncbi_uid=1029&link_uid=1029">CDKN2A</a><span class="no_uline"> - cyclin dependent <b>kinase</b> inhibitor 2A</span></p><div class="supp"><p class="details">This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 <b>kinase</b>. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]</p><div class="details"><dl><dt><strong>Also known as: </strong></dt><dd>ARF, CAI2, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16</dd></dl><dl><dt><strong>Chromosome: </strong></dt><dd>9; </dd><dt><strong>Location: </strong></dt><dd>9p21.3</dd></dl></div></div><div class="aux"><ul class="db_links"><li><a href="/gene/1029/" target="_blank">More about this gene</a></li></ul></div></div></div><div class="rprt"><div class="rprtnum">6.</div><div class="rslt"><p class="title"><a href="https://www.ncbi.nlm.nih.gov/gtr/genes/2475" ref="ncbi_uid=2475&link_uid=2475">MTOR</a><span class="no_uline"> - mechanistic target of rapamycin <b>kinase</b></span></p><div class="supp"><p class="details">The protein encoded by this gene belongs to a family of phosphatidylinositol <b>kinase</b>-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This <b>kinase</b> is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections. Mutations in this gene are associated with Smith-Kingsmore syndrome and somatic focal cortical dysplasia type II. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Aug 2020]</p><div class="details"><dl><dt><strong>Also known as: </strong></dt><dd>FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS</dd></dl><dl><dt><strong>Chromosome: </strong></dt><dd>1; </dd><dt><strong>Location: </strong></dt><dd>1p36.22</dd></dl></div></div><div class="aux"><ul class="db_links"><li><a href="/gene/2475/" target="_blank">More about this gene</a></li></ul></div></div></div><div class="rprt"><div class="rprtnum">7.</div><div class="rslt"><p class="title"><a href="https://www.ncbi.nlm.nih.gov/gtr/genes/6850" ref="ncbi_uid=6850&link_uid=6850">SYK</a><span class="no_uline"> - spleen associated tyrosine <b>kinase</b></span></p><div class="supp"><p class="details">This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]</p><div class="details"><dl><dt><strong>Also known as: </strong></dt><dd>IMD82, p72-Syk</dd></dl><dl><dt><strong>Chromosome: </strong></dt><dd>9; </dd><dt><strong>Location: </strong></dt><dd>9q22.2</dd></dl></div></div><div class="aux"><ul class="db_links"><li><a href="/gene/6850/" target="_blank">More about this gene</a></li></ul></div></div></div><div class="rprt"><div class="rprtnum">8.</div><div class="rslt"><p class="title"><a href="https://www.ncbi.nlm.nih.gov/gtr/genes/5313" ref="ncbi_uid=5313&link_uid=5313">PKLR</a><span class="no_uline"> - pyruvate <b>kinase</b> L/R</span></p><div class="supp"><p class="details">The protein encoded by this gene is a pyruvate <b>kinase</b> that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]</p><div class="details"><dl><dt><strong>Also known as: </strong></dt><dd>CNSHA2, PK1, PKL, PKRL, RPK</dd></dl><dl><dt><strong>Chromosome: </strong></dt><dd>1; </dd><dt><strong>Location: </strong></dt><dd>1q22</dd></dl></div></div><div class="aux"><ul class="db_links"><li><a href="/gene/5313/" target="_blank">More about this gene</a></li></ul></div></div></div><div class="rprt"><div class="rprtnum">9.</div><div class="rslt"><p class="title"><a href="https://www.ncbi.nlm.nih.gov/gtr/genes/3717" ref="ncbi_uid=3717&link_uid=3717">JAK2</a><span class="no_uline"> - Janus <b>kinase</b> 2</span></p><div class="supp"><p class="details">This gene encodes a non-receptor tyrosine <b>kinase</b> that plays a central role in cytokine and growth factor signalling. The primary isoform of this protein has an N-terminal FERM domain that is required for erythropoietin receptor association, an SH2 domain that binds STAT transcription factors, a pseudokinase domain and a C-terminal tyrosine <b>kinase</b> domain. Cytokine binding induces autophosphorylation and activation of this <b>kinase</b>. This <b>kinase</b> then recruits and phosphorylates signal transducer and activator of transcription (STAT) proteins. Growth factors like TGF-beta 1 also induce phosphorylation and activation of this <b>kinase</b> and translocation of downstream STAT proteins to the nucleus where they influence gene transcription. Mutations in this gene are associated with numerous inflammatory diseases and malignancies. This gene is a downstream target of the pleiotropic cytokine IL6 that is produced by B cells, T cells, dendritic cells and macrophages to produce an immune response or inflammation. Disregulation of the IL6/JAK2/STAT3 signalling pathways produces increased cellular proliferation and myeloproliferative neoplasms of hematopoietic stem cells. A nonsynonymous mutation in the pseudokinase domain of this gene disrupts the domains inhibitory effect and results in constitutive tyrosine phosphorylation activity and hypersensitivity to cytokine signalling. This gene and the IL6/JAK2/STAT3 signalling pathway is a therapeutic target for the treatment of excessive inflammatory responses to viral infections. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2020]</p><div class="details"><dl><dt><strong>Also known as: </strong></dt><dd>JTK10</dd></dl><dl><dt><strong>Chromosome: </strong></dt><dd>9; </dd><dt><strong>Location: </strong></dt><dd>9p24.1</dd></dl></div></div><div class="aux"><ul class="db_links"><li><a href="/gene/3717/" target="_blank">More about this gene</a></li></ul></div></div></div><div class="rprt"><div class="rprtnum">10.</div><div class="rslt"><p class="title"><a href="https://www.ncbi.nlm.nih.gov/gtr/genes/5594" ref="ncbi_uid=5594&link_uid=5594">MAPK1</a><span class="no_uline"> - mitogen-activated protein <b>kinase</b> 1</span></p><div class="supp"><p class="details">This gene encodes a member of the MAP <b>kinase</b> family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this <b>kinase</b> requires its phosphorylation by upstream kinases. Upon activation, this <b>kinase</b> translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its <b>kinase</b> activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]</p><div class="details"><dl><dt><strong>Also known as: </strong></dt><dd>ERK, ERK-2, ERK2, ERT1, MAPK2, NS13, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk, p42-MAPK</dd></dl><dl><dt><strong>Chromosome: </strong></dt><dd>22; </dd><dt><strong>Location: </strong></dt><dd>22q11.22</dd></dl></div></div><div class="aux"><ul class="db_links"><li><a href="/gene/5594/" target="_blank">More about this gene</a></li></ul></div></div></div><div class="rprt"><div class="rprtnum">11.</div><div class="rslt"><p class="title"><a href="https://www.ncbi.nlm.nih.gov/gtr/genes/5290" ref="ncbi_uid=5290&link_uid=5290">PIK3CA</a><span class="no_uline"> - phosphatidylinositol-4,5-bisphosphate 3-<b>kinase</b> catalytic subunit alpha</span></p><div class="supp"><p class="details">Phosphatidylinositol 3-<b>kinase</b> is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22. [provided by RefSeq, Apr 2016]</p><div class="details"><dl><dt><strong>Also known as: </strong></dt><dd>CCM4, CLAPO, CLOVE, CWS5, HMH, MCAP, MCM, MCMTC, PI3K, PI3K-alpha, p110-alpha</dd></dl><dl><dt><strong>Chromosome: </strong></dt><dd>3; </dd><dt><strong>Location: </strong></dt><dd>3q26.32</dd></dl></div></div><div class="aux"><ul class="db_links"><li><a href="/gene/5290/" target="_blank">More about this gene</a></li></ul></div></div></div><div class="rprt"><div class="rprtnum">12.</div><div class="rslt"><p class="title"><a href="https://www.ncbi.nlm.nih.gov/gtr/genes/1026" ref="ncbi_uid=1026&link_uid=1026">CDKN1A</a><span class="no_uline"> - cyclin dependent <b>kinase</b> inhibitor 1A</span></p><div class="supp"><p class="details">This gene encodes a potent cyclin-dependent <b>kinase</b> inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2015]</p><div class="details"><dl><dt><strong>Also known as: </strong></dt><dd>CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1</dd></dl><dl><dt><strong>Chromosome: </strong></dt><dd>6; </dd><dt><strong>Location: </strong></dt><dd>6p21.2</dd></dl></div></div><div class="aux"><ul class="db_links"><li><a href="/gene/1026/" target="_blank">More about this gene</a></li></ul></div></div></div><div class="rprt"><div class="rprtnum">13.</div><div class="rslt"><p class="title"><a href="https://www.ncbi.nlm.nih.gov/gtr/genes/472" ref="ncbi_uid=472&link_uid=472">ATM</a><span class="no_uline"> - ATM serine/threonine <b>kinase</b></span></p><div class="supp"><p class="details">The protein encoded by this gene belongs to the PI3/PI4-<b>kinase</b> family. This protein is an important cell cycle checkpoint <b>kinase</b> that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint <b>kinase</b> CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related <b>kinase</b> ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]</p><div class="details"><dl><dt><strong>Also known as: </strong></dt><dd>AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1</dd></dl><dl><dt><strong>Chromosome: </strong></dt><dd>11; </dd><dt><strong>Location: </strong></dt><dd>11q22.3</dd></dl></div></div><div class="aux"><ul class="db_links"><li><a href="/gene/472/" target="_blank">More about this gene</a></li></ul></div></div></div><div class="rprt"><div class="rprtnum">14.</div><div class="rslt"><p class="title"><a href="https://www.ncbi.nlm.nih.gov/gtr/genes/4233" ref="ncbi_uid=4233&link_uid=4233">MET</a><span class="no_uline"> - MET proto-oncogene, receptor tyrosine <b>kinase</b></span></p><div class="supp"><p class="details">This gene encodes a member of the receptor tyrosine <b>kinase</b> family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]</p><div class="details"><dl><dt><strong>Also known as: </strong></dt><dd>AUTS9, DA11, DFNB97, HGFR, RCCP2, c-Met</dd></dl><dl><dt><strong>Chromosome: </strong></dt><dd>7; </dd><dt><strong>Location: </strong></dt><dd>7q31.2</dd></dl></div></div><div class="aux"><ul class="db_links"><li><a href="/gene/4233/" target="_blank">More about this gene</a></li></ul></div></div></div><div class="rprt"><div class="rprtnum">15.</div><div class="rslt"><p class="title"><a href="https://www.ncbi.nlm.nih.gov/gtr/genes/3815" ref="ncbi_uid=3815&link_uid=3815">KIT</a><span class="no_uline"> - KIT proto-oncogene, receptor tyrosine <b>kinase</b></span></p><div class="supp"><p class="details">This gene encodes a receptor tyrosine <b>kinase</b>. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine <b>kinase</b> domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2020]</p><div class="details"><dl><dt><strong>Also known as: </strong></dt><dd>C-Kit, CD117, MASTC, PBT, SCFR</dd></dl><dl><dt><strong>Chromosome: </strong></dt><dd>4; </dd><dt><strong>Location: </strong></dt><dd>4q12</dd></dl></div></div><div class="aux"><ul class="db_links"><li><a href="/gene/3815/" target="_blank">More about this gene</a></li></ul></div></div></div><div class="rprt"><div class="rprtnum">16.</div><div class="rslt"><p class="title"><a href="https://www.ncbi.nlm.nih.gov/gtr/genes/120892" ref="ncbi_uid=120892&link_uid=120892">LRRK2</a><span class="no_uline"> - leucine rich repeat <b>kinase</b> 2</span></p><div class="supp"><p class="details">This gene is a member of the leucine-rich repeat <b>kinase</b> family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a <b>kinase</b> domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]</p><div class="details"><dl><dt><strong>Also known as: </strong></dt><dd>AURA17, DARDARIN, PARK8, RIPK7, ROCO2</dd></dl><dl><dt><strong>Chromosome: </strong></dt><dd>12; </dd><dt><strong>Location: </strong></dt><dd>12q12</dd></dl></div></div><div class="aux"><ul class="db_links"><li><a href="/gene/120892/" target="_blank">More about this gene</a></li></ul></div></div></div><div class="rprt"><div class="rprtnum">17.</div><div class="rslt"><p class="title"><a href="https://www.ncbi.nlm.nih.gov/gtr/genes/2932" ref="ncbi_uid=2932&link_uid=2932">GSK3B</a><span class="no_uline"> - glycogen synthase <b>kinase</b> 3 beta</span></p><div class="supp"><p class="details">The protein encoded by this gene is a serine-threonine <b>kinase</b> belonging to the glycogen synthase <b>kinase</b> subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]</p><div class="details"><dl><dt><strong>Chromosome: </strong></dt><dd>3; </dd><dt><strong>Location: </strong></dt><dd>3q13.33</dd></dl></div></div><div class="aux"><ul class="db_links"><li><a href="/gene/2932/" target="_blank">More about this gene</a></li></ul></div></div></div><div class="rprt"><div class="rprtnum">18.</div><div class="rslt"><p class="title"><a href="https://www.ncbi.nlm.nih.gov/gtr/genes/1432" ref="ncbi_uid=1432&link_uid=1432">MAPK14</a><span class="no_uline"> - mitogen-activated protein <b>kinase</b> 14</span></p><div class="supp"><p class="details">The protein encoded by this gene is a member of the MAP <b>kinase</b> family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This <b>kinase</b> is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP <b>kinase</b> kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this <b>kinase</b>. The substrates of this <b>kinase</b> include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this <b>kinase</b> in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]</p><div class="details"><dl><dt><strong>Also known as: </strong></dt><dd>CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA</dd></dl><dl><dt><strong>Chromosome: </strong></dt><dd>6; </dd><dt><strong>Location: </strong></dt><dd>6p21.31</dd></dl></div></div><div class="aux"><ul class="db_links"><li><a href="/gene/1432/" target="_blank">More about this gene</a></li></ul></div></div></div><div class="rprt"><div class="rprtnum">19.</div><div class="rslt"><p class="title"><a href="https://www.ncbi.nlm.nih.gov/gtr/genes/5979" ref="ncbi_uid=5979&link_uid=5979">RET</a><span class="no_uline"> - ret proto-oncogene</span></p><div class="supp"><p class="details">This gene encodes a transmembrane receptor and member of the tyrosine protein <b>kinase</b> family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017]</p><div class="details"><dl><dt><strong>Also known as: </strong></dt><dd>CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1</dd></dl><dl><dt><strong>Chromosome: </strong></dt><dd>10; </dd><dt><strong>Location: </strong></dt><dd>10q11.21</dd></dl></div></div><div class="aux"><ul class="db_links"><li><a href="/gene/5979/" target="_blank">More about this gene</a></li></ul></div></div></div><div class="rprt"><div class="rprtnum">20.</div><div class="rslt"><p class="title"><a href="https://www.ncbi.nlm.nih.gov/gtr/genes/6714" ref="ncbi_uid=6714&link_uid=6714">SRC</a><span class="no_uline"> - SRC proto-oncogene, non-receptor tyrosine <b>kinase</b></span></p><div class="supp"><p class="details">This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein <b>kinase</b> whose activity can be inhibited by phosphorylation by c-SRC <b>kinase</b>. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]</p><div class="details"><dl><dt><strong>Also known as: </strong></dt><dd>ASV, SRC1, THC6, c-SRC, p60-Src</dd></dl><dl><dt><strong>Chromosome: </strong></dt><dd>20; </dd><dt><strong>Location: </strong></dt><dd>20q11.23</dd></dl></div></div><div class="aux"><ul class="db_links"><li><a href="/gene/6714/" target="_blank">More about this gene</a></li></ul></div></div></div></div><div class="bottom"><div class="title_and_pager"><div class="pagination"><span class="inactive page_link"><< First</span><span class="inactive page_link prev">< Prev</span><h3 class="page">Page 1 of 60</h3><a href="https://www.ncbi.nlm.nih.gov/gtr/genes/?term=kinase&page=2" class="active page_link next" data-value="2">Next ></a><a href="https://www.ncbi.nlm.nih.gov/gtr/genes/?term=kinase&page=60" class="active page_link" data-value="60">Last >></a></div><div class="result_count_holder"><h2 class="result_count">Results: 1 to 20 of 1189</h2></div></div></div></div>
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