453 lines
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453 lines
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<span>TP53</span>
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<div class="rprt"><h1 class="g_title"><span class="gn"><em>TP53</em></span> tumor protein p53</h1><span class="geneid">Gene ID: 7157, updated on
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4-Mar-2025</span><br /><span class="geneid">Gene type: protein coding</span><br /><span class="known-as"><em>Also known as: </em>P53; BCC7; LFS1; BMFS5; TRP53</span><ul class="inline-list" style="padding-left:0;"><li><a href="https://www.ncbi.nlm.nih.gov/gtr/all/tests/?term=7157[geneid]" data-ga-label="see_all_available_tests">See all available tests in GTR for this gene</a></li><li><a href="/gene/7157/" ref="log_uid=7157&ncbi_uid=7157" data-ga-label="go_to_complete_gene_record">Go to complete Gene record for TP53</a></li><li><a href="/variation/view/?assm=GCF_000001405.25&q=TP53[gene]" ref="ncbi_uid=7157" data-ga-label="go_to_variation_viewer">Go to Variation Viewer for TP53 variants</a></li></ul><h2>Summary</h2><p>This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]</p><div id="associated-conditions"><h2>Associated conditions</h2><p><a href="/gtr/all/tests/?term=7157[geneid]" data-ga-label="see_all_available_tests">See all available tests in GTR for this gene</a></p><div class="associated-conditions-table"><table class="jig-ncbigrid gtr-associated-cond"><thead><tr><th class="description">Description</th><th>Tests</th></tr></thead><tbody><tr><td>A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.<div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span></div></td><td></td></tr><tr><td>A germline variant in the TP53 polyadenylation signal confers cancer susceptibility.<div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span></div></td><td></td></tr><tr><td><a href="/gtr/conditions/C1859972" ref="ncbi_uid=7157&link_uid=C1859972" data-ga-label="condition">Adrenocortical carcinoma, hereditary</a><div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C1859972" ref="ncbi_uid=7157&link_uid=C1859972" data-ga-label="medgen">C1859972</a></span><span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/202300" ref="ncbi_uid=7157" data-ga-label="omim"> 202300</a></span><span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span></div></td><td><a href="/gtr/all/labs/?term=C1859972[DISCUI]" ref="ncbi_uid=7157" data-ga-label="labs">See labs</a></td></tr><tr><td><a href="/gtr/conditions/C3553606" ref="ncbi_uid=7157&link_uid=C3553606" data-ga-label="condition">Basal cell carcinoma, susceptibility to, 7</a><div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C3553606" ref="ncbi_uid=7157&link_uid=C3553606" data-ga-label="medgen">C3553606</a></span><span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/614740" ref="ncbi_uid=7157" data-ga-label="omim"> 614740</a></span><span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span></div></td><td><a href="/gtr/all/labs/?term=C3553606[DISCUI]" ref="ncbi_uid=7157" data-ga-label="labs">See labs</a></td></tr><tr><td><a href="/gtr/conditions/C4748488" ref="ncbi_uid=7157&link_uid=C4748488" data-ga-label="condition">Bone marrow failure syndrome 5</a><div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C4748488" ref="ncbi_uid=7157&link_uid=C4748488" data-ga-label="medgen">C4748488</a></span><span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/618165" ref="ncbi_uid=7157" data-ga-label="omim"> 618165</a></span><span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span></div></td><td><a href="/gtr/all/labs/?term=C4748488[DISCUI]" ref="ncbi_uid=7157" data-ga-label="labs">See labs</a></td></tr><tr><td><a href="/gtr/conditions/C0585442" ref="ncbi_uid=7157&link_uid=C0585442" data-ga-label="condition">Bone osteosarcoma</a><div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C0585442" ref="ncbi_uid=7157&link_uid=C0585442" data-ga-label="medgen">C0585442</a></span><span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/259500" ref="ncbi_uid=7157" data-ga-label="omim"> 259500</a></span><span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span></div></td><td><a href="/gtr/all/labs/?term=C0585442[DISCUI]" ref="ncbi_uid=7157" data-ga-label="labs">See labs</a></td></tr><tr><td><a href="/gtr/conditions/C0205770" ref="ncbi_uid=7157&link_uid=C0205770" data-ga-label="condition">Choroid plexus papilloma</a><div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C0205770" ref="ncbi_uid=7157&link_uid=C0205770" data-ga-label="medgen">C0205770</a></span><span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/260500" ref="ncbi_uid=7157" data-ga-label="omim"> 260500</a></span><span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span></div></td><td><a href="/gtr/all/labs/?term=C0205770[DISCUI]" ref="ncbi_uid=7157" data-ga-label="labs">See labs</a></td></tr><tr><td><a href="/gtr/conditions/C0346629" ref="ncbi_uid=7157&link_uid=C0346629" data-ga-label="condition">Colorectal cancer</a><div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C0346629" ref="ncbi_uid=7157&link_uid=C0346629" data-ga-label="medgen">C0346629</a></span><span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/114500" ref="ncbi_uid=7157" data-ga-label="omim"> 114500</a></span><span class="gtr-associated-cond-extra-i">GeneReviews: <a href="/books/NBK1211" ref="ncbi_uid=7157" data-ga-label="gene_reviews">Lynch Syndrome</a></span></div></td><td><a href="/gtr/all/labs/?term=C0346629[DISCUI]" ref="ncbi_uid=7157" data-ga-label="labs">See labs</a></td></tr><tr><td><a href="/gtr/conditions/C0346153" ref="ncbi_uid=7157&link_uid=C0346153" data-ga-label="condition">Familial cancer of breast</a><div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C0346153" ref="ncbi_uid=7157&link_uid=C0346153" data-ga-label="medgen">C0346153</a></span><span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/114480" ref="ncbi_uid=7157" data-ga-label="omim"> 114480</a></span><span class="gtr-associated-cond-extra-i">GeneReviews: <a href="/books/NBK1247" ref="ncbi_uid=7157" data-ga-label="gene_reviews">BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer</a></span></div></td><td><a href="/gtr/all/labs/?term=C0346153[DISCUI]" ref="ncbi_uid=7157" data-ga-label="labs">See labs</a></td></tr><tr><td><a href="/gtr/conditions/C2931038" ref="ncbi_uid=7157&link_uid=C2931038" data-ga-label="condition">Familial pancreatic carcinoma</a><div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C2931038" ref="ncbi_uid=7157&link_uid=C2931038" data-ga-label="medgen">C2931038</a></span><span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/260350" ref="ncbi_uid=7157" data-ga-label="omim"> 260350</a></span><span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span></div></td><td><a href="/gtr/all/labs/?term=C2931038[DISCUI]" ref="ncbi_uid=7157" data-ga-label="labs">See labs</a></td></tr><tr><td>Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma.<div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span></div></td><td></td></tr><tr><td><a href="/gtr/conditions/C2750850" ref="ncbi_uid=7157&link_uid=C2750850" data-ga-label="condition">Glioma susceptibility 1</a><div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C2750850" ref="ncbi_uid=7157&link_uid=C2750850" data-ga-label="medgen">C2750850</a></span><span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/137800" ref="ncbi_uid=7157" data-ga-label="omim"> 137800</a></span><span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span></div></td><td><a href="/gtr/all/labs/?term=C2750850[DISCUI]" ref="ncbi_uid=7157" data-ga-label="labs">See labs</a></td></tr><tr><td><a href="/gtr/conditions/C2239176" ref="ncbi_uid=7157&link_uid=C2239176" data-ga-label="condition">Hepatocellular carcinoma</a><div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C2239176" ref="ncbi_uid=7157&link_uid=C2239176" data-ga-label="medgen">C2239176</a></span><span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/114550" ref="ncbi_uid=7157" data-ga-label="omim"> 114550</a></span><span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span></div></td><td><a href="/gtr/all/labs/?term=C2239176[DISCUI]" ref="ncbi_uid=7157" data-ga-label="labs">See labs</a></td></tr><tr><td>Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.<div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span></div></td><td></td></tr><tr><td><a href="/gtr/conditions/C0085390" ref="ncbi_uid=7157&link_uid=C0085390" data-ga-label="condition">Li-Fraumeni syndrome</a><div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C0085390" ref="ncbi_uid=7157&link_uid=C0085390" data-ga-label="medgen">C0085390</a></span><span class="gtr-associated-cond-extra-i">GeneReviews: <a href="/books/NBK1311" ref="ncbi_uid=7157" data-ga-label="gene_reviews">Li-Fraumeni Syndrome</a></span></div></td><td><a href="/gtr/all/labs/?term=C0085390[DISCUI]" ref="ncbi_uid=7157" data-ga-label="labs">See labs</a></td></tr><tr><td><a href="/gtr/conditions/C1835398" ref="ncbi_uid=7157&link_uid=C1835398" data-ga-label="condition">Li-Fraumeni syndrome 1</a><div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C1835398" ref="ncbi_uid=7157&link_uid=C1835398" data-ga-label="medgen">C1835398</a></span><span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/151623" ref="ncbi_uid=7157" data-ga-label="omim"> 151623</a></span><span class="gtr-associated-cond-extra-i">GeneReviews: <a href="/books/NBK1294" ref="ncbi_uid=7157" data-ga-label="gene_reviews">Wilms Tumor Predisposition</a>, <a href="/books/NBK1311" ref="ncbi_uid=7157" data-ga-label="gene_reviews">Li-Fraumeni Syndrome</a></span></div></td><td><a href="/gtr/all/labs/?term=C1835398[DISCUI]" ref="ncbi_uid=7157" data-ga-label="labs">See labs</a></td></tr><tr><td><a href="/gtr/conditions/C2931822" ref="ncbi_uid=7157&link_uid=C2931822" data-ga-label="condition">Nasopharyngeal carcinoma</a><div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C2931822" ref="ncbi_uid=7157&link_uid=C2931822" data-ga-label="medgen">C2931822</a></span><span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/607107" ref="ncbi_uid=7157" data-ga-label="omim"> 607107</a></span><span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span></div></td><td><a href="/gtr/all/labs/?term=C2931822[DISCUI]" ref="ncbi_uid=7157" data-ga-label="labs">See labs</a></td></tr></tbody></table></div></div><div id="copy-number-of-resp"><h2>Copy number response</h2><div><table class="jig-ncbigrid gtr-associated-cond" data-jigconfig="isPageable: true, pageSize: 10"><thead><tr><th class="description">Description</th></tr></thead><tbody><tr><td>Copy number response<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">Triplosensitivity</span><div><p>No evidence available (Last evaluated 2021-11-10)</p><span class="gtr-associated-cond-extra-i"><a href="https://www.ncbi.nlm.nih.gov/projects/dbvar/ISCA/isca_gene.cgi?sym=TP53">ClinGen Genome Curation Page</a></span></div></div><div class="gtr-associated-cond-extra-c"><span style="color:#000;">Haploinsufficency</span><div><p>Sufficient evidence for dosage pathogenicity (Last evaluated 2021-11-10)</p><span class="gtr-associated-cond-extra-i"><a href="https://www.ncbi.nlm.nih.gov/projects/dbvar/ISCA/isca_gene.cgi?sym=TP53">ClinGen Genome Curation Page</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/12584563,21056402,26014290,26681312,28369373">PubMed</a></span></div></div></div></td></tr></tbody></table></div></div><div id="genomic-context"><h2>Genomic context</h2><div class="map_location_wr"><div class="ch_location-wr"><dl class="chr_location"><dt>Location:</dt><dd>17p13.1</dd></dl><dl class="chr_location"><dt>Sequence: </dt><dd>Chromosome: 17; NC_000017.11 (7668421..7687490, complement)</dd></dl><dl class="chr_location"><dt>Total number of exons:</dt><dd>13</dd></dl></div><div class="note-link"></div></div><div class="viewer"><div class="choose"><label for="accession" class="label">Genomic Sequence </label><select name="accessionList" sid="1" id="accessionList"><option value="NC_000017.11_7668420_7687489" data-assembly="GRCh38.p14">NC_000017 Chromosome 17 Reference GRCh38.p14 Primary Assembly (location A)</option><option value="NC_000017.10_7571738_7590807" data-assembly="GRCh37.p13">NC_000017 Chromosome 17 Reference GRCh37.p13 Primary Assembly (location B)</option><option value="NC_060941.1_7572543_7591593" data-assembly="T2T-CHM13v2.0">NC_060941 Chromosome 17 Alternate T2T-CHM13v2.0 (location A)</option><option value="NG_017013.2_5000_24148" data-assembly="">NG_017013 RefSeqGene</option></select></div><script type="text/javascript" src="/projects/sviewer/js/sviewer.js" id="autoload"></script><div id="NC_000017" class="divAccession"><div class="seq-viewer"><p class="note-link"><strong>Go to nucleotide</strong><a href="/nuccore/NC_000017.11?report=graph&from=7665560&to=7690349&strand=true&tracks=[key:sequence_track,name:Sequence,display_name:Sequence,category:Sequence,annots:Sequence,ShowLabel:false][key:gene_model_track,name:Genes---Unnamed,display_name:Genes,annots:Unnamed,Options:MergePairs,SNPs:false,CDSProductFeats:true,ShowLabelsForAllFeatures:true,HighlightMode:2][key:feature_track,name:Genes---other,display_name:Genes - other,subkey:ncRNA,annots:other,Layout:Adaptive][key:feature_track,name:Genes---tRNA,display_name:Genes - tRNA,subkey:tRNA,annots:tRNA,Layout:Adaptive][key:SNP_track,name:SNP,annots:SNP,Layout:Adaptive][key:SNP_Bins_track,name:Clinical Variants][key:SNP_Bins_track,name:Cited Variants][key:GWAS_track,name:GWAS Tracks,display_name:Association Results]" title="Nucleotide graphic report" ref="ordinalpos=1&ncbi_uid=&link_uid=NC_000017.11">Graphics</a> <a href="/nuccore/NC_000017.11?report=fasta&from=7665560&to=7690349&strand=true" title="Nucleotide graphic report" ref="ordinalpos=1&ncbi_uid=&link_uid=NC_000017.11">FASTA</a> <a href="/nuccore/NC_000017.11?report=genbank&from=7665560&to=7690349&strand=true" title="Nucleotide GenBank report" ref="ordinalpos=1&ncbi_uid=&link_uid=NC_000017.11">GenBank</a> </p><div id="divNC_000017" class="SeqViewerApp" style="clear:both;" data-sv="appname=ncbi-portal-gtr&embedded=true&noslider=1&id=NC_000017.11&from=7665560&to=7690349&strand=true&tracks=[key:sequence_track,name:Sequence,display_name:Sequence,category:Sequence,annots:Sequence,ShowLabel:false][key:gene_model_track,name:Genes---Unnamed,display_name:Genes,annots:Unnamed,Options:MergePairs,SNPs:false,CDSProductFeats:true,ShowLabelsForAllFeatures:true,HighlightMode:2][key:feature_track,name:Genes---other,display_name:Genes - other,subkey:ncRNA,annots:other,Layout:Adaptive][key:feature_track,name:Genes---tRNA,display_name:Genes - tRNA,subkey:tRNA,annots:tRNA,Layout:Adaptive][key:SNP_track,name:SNP,annots:SNP,Layout:Adaptive][key:SNP_Bins_track,name:Clinical Variants][key:SNP_Bins_track,name:Cited Variants][key:GWAS_track,name:GWAS Tracks,display_name:Association Results]"><a href="?appname=ncbi-portal-gtr&embedded=true&noslider=1&id=NC_000017.11&from=7665560&to=7690349&strand=true&tracks=[key:sequence_track,name:Sequence,display_name:Sequence,category:Sequence,annots:Sequence,ShowLabel:false][key:gene_model_track,name:Genes---Unnamed,display_name:Genes,annots:Unnamed,Options:MergePairs,SNPs:false,CDSProductFeats:true,ShowLabelsForAllFeatures:true,HighlightMode:2][key:feature_track,name:Genes---other,display_name:Genes - other,subkey:ncRNA,annots:other,Layout:Adaptive][key:feature_track,name:Genes---tRNA,display_name:Genes - tRNA,subkey:tRNA,annots:tRNA,Layout:Adaptive][key:SNP_track,name:SNP,annots:SNP,Layout:Adaptive][key:SNP_Bins_track,name:Clinical Variants][key:SNP_Bins_track,name:Cited Variants][key:GWAS_track,name:GWAS Tracks,display_name:Association Results]"></a></div></div></div><input name="nucleotideLink_NC_000017.11" sid="1" type="hidden" id="nucleotideLink_NC_000017_11_7668420_7687489" value="<p class="note-link"><strong class="margin_r1">Go to nucleotide</strong><a title="Nucleotide Graphic report" href="/nuccore/NC_000017.11?report=graph&amp;from=7665560&amp;to=7690349&amp;strand=true&amp;content=5" ref="ordinalpos=1&amp;ncbi_uid=&amp;link_uid=NC_000017.11">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NC_000017.11?report=fasta&amp;from=7668421&amp;to=7687490&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=&amp;link_uid=NC_000017.11">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NC_000017.11?report=genbank&amp;from=7668421&amp;to=7687490&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=&amp;link_uid=NC_000017.11">GenBank</a></p>" /><input name="relString_NC_000017.11" sid="1" type="hidden" id="relString_NC_000017_11_7668420_7687489" value="embedded=true&amp;noslider=1&amp;id=NC_000017.11&amp;from=7665560&amp;to=7690349&amp;strand=true&amp;content=5" /><input name="nucleotideLink_NG_017013.2" sid="1" type="hidden" id="nucleotideLink_NG_017013_2_5000_24148" value="<p class="note-link"><strong class="margin_r1">Go to nucleotide</strong><a title="Nucleotide Graphic report" href="/nuccore/NG_017013.2?report=graph&amp;from=2128&amp;to=27020&amp;content=5" ref="ordinalpos=1&amp;ncbi_uid=&amp;link_uid=NG_017013.2">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NG_017013.2?report=fasta&amp;from=5001&amp;to=24149" ref="ordinalpos=1&amp;ncbi_uid=&amp;link_uid=NG_017013.2">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NG_017013.2?report=genbank&amp;from=5001&amp;to=24149" ref="ordinalpos=1&amp;ncbi_uid=&amp;link_uid=NG_017013.2">GenBank</a></p>" /><input name="relString_NG_017013.2" sid="1" type="hidden" id="relString_NG_017013_2_5000_24148" value="embedded=true&amp;noslider=1&amp;id=NG_017013.2&amp;from=2128&amp;to=27020&amp;content=5" /><input name="nucleotideLink_NC_060941.1" sid="1" type="hidden" id="nucleotideLink_NC_060941_1_7572543_7591593" value="<p class="note-link"><strong class="margin_r1">Go to nucleotide</strong><a title="Nucleotide Graphic report" href="/nuccore/NC_060941.1?report=graph&amp;from=7569685&amp;to=7594451&amp;strand=true&amp;content=5" ref="ordinalpos=1&amp;ncbi_uid=&amp;link_uid=NC_060941.1">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NC_060941.1?report=fasta&amp;from=7572544&amp;to=7591594&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=&amp;link_uid=NC_060941.1">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NC_060941.1?report=genbank&amp;from=7572544&amp;to=7591594&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=&amp;link_uid=NC_060941.1">GenBank</a></p>" /><input name="relString_NC_060941.1" sid="1" type="hidden" id="relString_NC_060941_1_7572543_7591593" value="embedded=true&amp;noslider=1&amp;id=NC_060941.1&amp;from=7569685&amp;to=7594451&amp;strand=true&amp;content=5" /><input name="nucleotideLink_NC_000017.10" sid="1" type="hidden" id="nucleotideLink_NC_000017_10_7571738_7590807" value="<p class="note-link"><strong class="margin_r1">Go to nucleotide</strong><a title="Nucleotide Graphic report" href="/nuccore/NC_000017.10?report=graph&amp;from=7568878&amp;to=7593667&amp;strand=true&amp;content=5" ref="ordinalpos=1&amp;ncbi_uid=&amp;link_uid=NC_000017.10">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NC_000017.10?report=fasta&amp;from=7571739&amp;to=7590808&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=&amp;link_uid=NC_000017.10">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NC_000017.10?report=genbank&amp;from=7571739&amp;to=7590808&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=&amp;link_uid=NC_000017.10">GenBank</a></p>" /><input name="relString_NC_000017.10" sid="1" type="hidden" id="relString_NC_000017_10_7571738_7590807" value="embedded=true&amp;noslider=1&amp;id=NC_000017.10&amp;from=7568878&amp;to=7593667&amp;strand=true&amp;content=5" /></div></div><div id="variation"><h2>Variation</h2><div class="ui-ncbigrid-outer-div"><div class="ui-ncbigrid-inner-div"><table class="jig-ncbigrid" data-jigconfig=""><thead><tr><th>Resource</th><th>Links for this gene</th></tr></thead><tbody><tr><td>ClinVar</td><td><a href="/clinvar?LinkName=gene_clinvar&from_uid=7157" ref="log$=recordlinks">Variants reported to ClinVar</a></td></tr><tr><td>dbVar</td><td><a href="/dbvar?LinkName=gene_dbvar&from_uid=7157" ref="log$=recordlinks">Studies and variants</a></td></tr><tr><td>SNP</td><td><a href="https://www.ncbi.nlm.nih.gov/variation/view/?q=TP53%5bgenesymbol%5d&filters=source:dbsnp" ref="ncbi_uid=7157">Variation Viewer for TP53 variants</a></td></tr><tr><td>Genome viewer</td><td><a href="https://www.ncbi.nlm.nih.gov/genome/gdv/?id=GSM923418,GSM923422,GSM923420&context=GEO&assm=GCF_000001405.25&q=TP53%5bgenesymbol%5d">Explore NCBI-annotated and select non-NCBI annotated genome assemblies</a></td></tr></tbody></table></div></div></div><div id="related-pubmed"><h2>Related articles in PubMed</h2><dl><dt><a href="/pubmed?LinkName=gene_pubmed_citedinomim&from_uid=7157" ref="ncbi_uid=7157&from=gtr_gene_related_pubmed_section" data-ga-label="pubmed_omim">PubMed-OMIM</a></dt><dd>publications in PubMed explicitly cited by the gene record in OMIM.
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</dd><dt><a href="/pubmed/clinical/?term=TP53" data-ga-label="pubmed_clinical">PubMed Clinical Queries</a></dt><dd>publications in PubMed limited specific clinical
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research.</dd><dt><a href="/pubmed/?LinkName=gene_pubmed&from_uid=7157" data-ga-label="pubmed_all_related">All related articles in PubMed</a></dt><dd>sorted by relevance are shown below. <a href="/pubmed/?LinkName=gene_pubmed&from_uid=7157" data-ga-label="pubmed_all_related">Click to see all (11592) citations.</a></dd></dl><div class="generefbl-link"><ol class="generef-link"><li><a href="/pubmed/27129168/" ref="ncbi_uid=7157&link_uid=27129168" data-ga-label="pubmed_article">TP53 mutations and protein immunopositivity may predict for poor outcome but also for trastuzumab benefit in patients with early breast cancer treated in the adjuvant setting.</a><span class="pubmed-auth-date"><br />Fountzilas G, Giannoulatou E, Alexopoulou Z, Zagouri F, Timotheadou E, Papadopoulou K, Lakis S, Bobos M, Poulios C, Sotiropoulou M, Lyberopoulou A, Gogas H, Pentheroudakis G, Pectasides D, Koutras A, Christodoulou C, Papandreou C, Samantas E, Papakostas P, Kosmidis P, Bafaloukos D, Karanikiotis C, Dimopoulos MA, Kotoula VFountzilas G, <em>et al</em>. Oncotarget, 2016 May 31. PMID 27129168</span></li><li><a href="/pubmed/19232460/" ref="ncbi_uid=7157&link_uid=19232460" data-ga-label="pubmed_article">A recombinant cell-permeable p53 fusion protein is selectively stabilized under hypoxia and inhibits tumor cell growth.</a><span class="pubmed-auth-date"><br />Yu Z, Wu J, Wu S, Jia P, Tong Y, Wu X, Wang YYu Z, <em>et al</em>. Cancer Lett, 2009 Jun 28. PMID 19232460</span></li><li><a href="/pubmed/19228762/" ref="ncbi_uid=7157&link_uid=19228762" data-ga-label="pubmed_article">Influence of p53 and genetic background on prenatal oogenesis and oocyte attrition in mice.</a><span class="pubmed-auth-date"><br />Ghafari F, Pelengaris S, Walters E, Hartshorne GMGhafari F, <em>et al</em>. Hum Reprod, 2009 Jun. PMID 19228762</span></li><li><a href="/pubmed/27115339/" ref="ncbi_uid=7157&link_uid=27115339" data-ga-label="pubmed_article">Upregulation of P53 promoted G1 arrest and apoptosis in human umbilical cord vein endothelial cells from preeclampsia.</a><span class="pubmed-auth-date"><br />Gao Q, Zhu X, Chen J, Mao C, Zhang L, Xu ZGao Q, <em>et al</em>. J Hypertens, 2016 Jul. PMID 27115339</span></li><li><a href="/pubmed/27121307/" ref="ncbi_uid=7157&link_uid=27121307" data-ga-label="pubmed_article">Proteomic mapping of p53 immunogenicity in pancreatic, ovarian, and breast cancers.</a><span class="pubmed-auth-date"><br />Katchman BA, Barderas R, Alam R, Chowell D, Field MS, Esserman LJ, Wallstrom G, LaBaer J, Cramer DW, Hollingsworth MA, Anderson KSKatchman BA, <em>et al</em>. Proteomics Clin Appl, 2016 Jul. PMID 27121307</span></li></ol></div></div></div>
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