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<span>BRCA2</span>
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<div class="rprt"><h1 class="g_title"><span class="gn"><em>BRCA2</em></span> BRCA2 DNA repair associated</h1><span class="geneid">Gene ID: 675, updated on
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4-Mar-2025</span><br /><span class="geneid">Gene type: protein coding</span><br /><span class="known-as"><em>Also known as: </em>FAD; FACD; FAD1; GLM3; BRCC2; FANCD; PNCA2; FANCD1; XRCC11; BROVCA2</span><ul class="inline-list" style="padding-left:0;"><li><a href="https://www.ncbi.nlm.nih.gov/gtr/all/tests/?term=675[geneid]" data-ga-label="see_all_available_tests">See all available tests in GTR for this gene</a></li><li><a href="/gene/675/" ref="log_uid=675&ncbi_uid=675" data-ga-label="go_to_complete_gene_record">Go to complete Gene record for BRCA2</a></li><li><a href="/variation/view/?assm=GCF_000001405.25&q=BRCA2[gene]" ref="ncbi_uid=675" data-ga-label="go_to_variation_viewer">Go to Variation Viewer for BRCA2 variants</a></li></ul><h2>Summary</h2><p>Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The largest exon in both genes is exon 11, which harbors the most important and frequent mutations in breast cancer patients. The BRCA2 gene was found on chromosome 13q12.3 in human. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, May 2020]</p><div id="associated-conditions"><h2>Associated conditions</h2><p><a href="/gtr/all/tests/?term=675[geneid]" data-ga-label="see_all_available_tests">See all available tests in GTR for this gene</a></p><div class="associated-conditions-table"><table class="jig-ncbigrid gtr-associated-cond"><thead><tr><th class="description">Description</th><th>Tests</th></tr></thead><tbody><tr><td><a href="/gtr/conditions/C2675520" ref="ncbi_uid=675&link_uid=C2675520" data-ga-label="condition">Breast-ovarian cancer, familial, susceptibility to, 2</a><div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C2675520" ref="ncbi_uid=675&link_uid=C2675520" data-ga-label="medgen">C2675520</a></span><span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/612555" ref="ncbi_uid=675" data-ga-label="omim"> 612555</a></span><span class="gtr-associated-cond-extra-i">GeneReviews: <a href="/books/NBK1247" ref="ncbi_uid=675" data-ga-label="gene_reviews">BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer</a></span></div></td><td><a href="/gtr/all/labs/?term=C2675520[DISCUI]" ref="ncbi_uid=675" data-ga-label="labs">See labs</a></td></tr><tr><td>Discovery and refinement of loci associated with lipid levels.<div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span></div></td><td></td></tr><tr><td><a href="/gtr/conditions/C0346153" ref="ncbi_uid=675&link_uid=C0346153" data-ga-label="condition">Familial cancer of breast</a><div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C0346153" ref="ncbi_uid=675&link_uid=C0346153" data-ga-label="medgen">C0346153</a></span><span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/114480" ref="ncbi_uid=675" data-ga-label="omim"> 114480</a></span><span class="gtr-associated-cond-extra-i">GeneReviews: <a href="/books/NBK1247" ref="ncbi_uid=675" data-ga-label="gene_reviews">BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer</a></span></div></td><td><a href="/gtr/all/labs/?term=C0346153[DISCUI]" ref="ncbi_uid=675" data-ga-label="labs">See labs</a></td></tr><tr><td><a href="/gtr/conditions/C2931456" ref="ncbi_uid=675&link_uid=C2931456" data-ga-label="condition">Familial prostate cancer</a><div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C2931456" ref="ncbi_uid=675&link_uid=C2931456" data-ga-label="medgen">C2931456</a></span><span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/176807" ref="ncbi_uid=675" data-ga-label="omim"> 176807</a></span><span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span></div></td><td><a href="/gtr/all/labs/?term=C2931456[DISCUI]" ref="ncbi_uid=675" data-ga-label="labs">See labs</a></td></tr><tr><td><a href="/gtr/conditions/C1838457" ref="ncbi_uid=675&link_uid=C1838457" data-ga-label="condition">Fanconi anemia complementation group D1</a><div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C1838457" ref="ncbi_uid=675&link_uid=C1838457" data-ga-label="medgen">C1838457</a></span><span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/605724" ref="ncbi_uid=675" data-ga-label="omim"> 605724</a></span><span class="gtr-associated-cond-extra-i">GeneReviews: <a href="/books/NBK1294" ref="ncbi_uid=675" data-ga-label="gene_reviews">Wilms Tumor Predisposition</a>, <a href="/books/NBK1401" ref="ncbi_uid=675" data-ga-label="gene_reviews">Fanconi Anemia</a></span></div></td><td><a href="/gtr/all/labs/?term=C1838457[DISCUI]" ref="ncbi_uid=675" data-ga-label="labs">See labs</a></td></tr><tr><td>Genome-wide association studies identify four ER negative-specific breast cancer risk loci.<div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span></div></td><td></td></tr><tr><td><a href="/gtr/conditions/C2751641" ref="ncbi_uid=675&link_uid=C2751641" data-ga-label="condition">Glioma susceptibility 3</a><div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C2751641" ref="ncbi_uid=675&link_uid=C2751641" data-ga-label="medgen">C2751641</a></span><span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/613029" ref="ncbi_uid=675" data-ga-label="omim"> 613029</a></span><span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span></div></td><td><a href="/gtr/all/labs/?term=C2751641[DISCUI]" ref="ncbi_uid=675" data-ga-label="labs">See labs</a></td></tr><tr><td><a href="/gtr/conditions/C0677776" ref="ncbi_uid=675&link_uid=C0677776" data-ga-label="condition">Hereditary breast ovarian cancer syndrome</a><div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C0677776" ref="ncbi_uid=675&link_uid=C0677776" data-ga-label="medgen">C0677776</a></span><span class="gtr-associated-cond-extra-i">GeneReviews: <a href="/books/NBK1247" ref="ncbi_uid=675" data-ga-label="gene_reviews">BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer</a></span></div></td><td><a href="/gtr/all/labs/?term=C0677776[DISCUI]" ref="ncbi_uid=675" data-ga-label="labs">See labs</a></td></tr><tr><td>Large-scale genotyping identifies 41 new loci associated with breast cancer risk.<div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span></div></td><td></td></tr><tr><td><a href="/gtr/conditions/C0025149" ref="ncbi_uid=675&link_uid=C0025149" data-ga-label="condition">Medulloblastoma</a><div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C0025149" ref="ncbi_uid=675&link_uid=C0025149" data-ga-label="medgen">C0025149</a></span><span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/155255" ref="ncbi_uid=675" data-ga-label="omim"> 155255</a></span><span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span></div></td><td><a href="/gtr/all/labs/?term=C0025149[DISCUI]" ref="ncbi_uid=675" data-ga-label="labs">See labs</a></td></tr><tr><td><a href="/gtr/conditions/C3150546" ref="ncbi_uid=675&link_uid=C3150546" data-ga-label="condition">Pancreatic cancer, susceptibility to, 2</a><div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C3150546" ref="ncbi_uid=675&link_uid=C3150546" data-ga-label="medgen">C3150546</a></span><span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/613347" ref="ncbi_uid=675" data-ga-label="omim"> 613347</a></span><span class="gtr-associated-cond-extra-i">GeneReviews: <a href="/books/NBK1247" ref="ncbi_uid=675" data-ga-label="gene_reviews">BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer</a></span></div></td><td><a href="/gtr/all/labs/?term=C3150546[DISCUI]" ref="ncbi_uid=675" data-ga-label="labs">See labs</a></td></tr><tr><td>Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer.<div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span></div></td><td></td></tr><tr><td><a href="/gtr/conditions/CN033288" ref="ncbi_uid=675&link_uid=CN033288" data-ga-label="condition">Wilms tumor 1</a><div class="gtr-associated-cond-extra"><span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/CN033288" ref="ncbi_uid=675&link_uid=CN033288" data-ga-label="medgen">CN033288</a></span><span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/194070" ref="ncbi_uid=675" data-ga-label="omim"> 194070</a></span><span class="gtr-associated-cond-extra-i">GeneReviews: <a href="/books/NBK1294" ref="ncbi_uid=675" data-ga-label="gene_reviews">Wilms Tumor Predisposition</a>, <a href="/books/NBK1360" ref="ncbi_uid=675" data-ga-label="gene_reviews">PAX6-Related Aniridia</a>, <a href="/books/NBK556455" ref="ncbi_uid=675" data-ga-label="gene_reviews">WT1 Disorder</a></span></div></td><td><a href="/gtr/all/labs/?term=CN033288[DISCUI]" ref="ncbi_uid=675" data-ga-label="labs">See labs</a></td></tr></tbody></table></div></div><div id="copy-number-of-resp"><h2>Copy number response</h2><div><table class="jig-ncbigrid gtr-associated-cond" data-jigconfig="isPageable: true, pageSize: 10"><thead><tr><th class="description">Description</th></tr></thead><tbody><tr><td>Copy number response<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">Haploinsufficency</span><div><p>Sufficient evidence for dosage pathogenicity (Last evaluated 2021-07-14)</p><span class="gtr-associated-cond-extra-i"><a href="https://www.ncbi.nlm.nih.gov/projects/dbvar/ISCA/isca_gene.cgi?sym=BRCA2">ClinGen Genome Curation Page</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/11897832,12097290,12569143,16199546,17063271,25632310">PubMed</a></span></div></div><div class="gtr-associated-cond-extra-c"><span style="color:#000;">Triplosensitivity</span><div><p>No evidence available (Last evaluated 2021-07-14)</p><span class="gtr-associated-cond-extra-i"><a href="https://www.ncbi.nlm.nih.gov/projects/dbvar/ISCA/isca_gene.cgi?sym=BRCA2">ClinGen Genome Curation Page</a></span></div></div></div></td></tr></tbody></table></div></div><div id="genomic-context"><h2>Genomic context</h2><div class="map_location_wr"><div class="ch_location-wr"><dl class="chr_location"><dt>Location:</dt><dd>13q13.1</dd></dl><dl class="chr_location"><dt>Sequence: </dt><dd>Chromosome: 13; NC_000013.11 (32315077..32400268)</dd></dl><dl class="chr_location"><dt>Total number of exons:</dt><dd>29</dd></dl></div><div class="note-link"></div></div><div class="viewer"><div class="choose"><label for="accession" class="label">Genomic Sequence </label><select name="accessionList" sid="1" id="accessionList"><option value="NC_000013.11_32315076_32400267" data-assembly="GRCh38.p14">NC_000013 Chromosome 13 Reference GRCh38.p14 Primary Assembly (location A)</option><option value="NC_000013.10_32889213_32974404" data-assembly="GRCh37.p13">NC_000013 Chromosome 13 Reference GRCh37.p13 Primary Assembly (location B)</option><option value="NC_060937.1_31532321_31617509" data-assembly="T2T-CHM13v2.0">NC_060937 Chromosome 13 Alternate T2T-CHM13v2.0 (location A)</option><option value="NG_012772.3_5000_89192" data-assembly="">NG_012772 RefSeqGene</option></select></div><script type="text/javascript" src="/projects/sviewer/js/sviewer.js" id="autoload"></script><div id="NC_000013" class="divAccession"><div class="seq-viewer"><p class="note-link"><strong>Go to nucleotide</strong><a href="/nuccore/NC_000013.11?report=graph&from=32302297&to=32413046&tracks=[key:sequence_track,name:Sequence,display_name:Sequence,category:Sequence,annots:Sequence,ShowLabel:false][key:gene_model_track,name:Genes---Unnamed,display_name:Genes,annots:Unnamed,Options:MergePairs,SNPs:false,CDSProductFeats:true,ShowLabelsForAllFeatures:true,HighlightMode:2][key:feature_track,name:Genes---other,display_name:Genes - other,subkey:ncRNA,annots:other,Layout:Adaptive][key:feature_track,name:Genes---tRNA,display_name:Genes - tRNA,subkey:tRNA,annots:tRNA,Layout:Adaptive][key:SNP_track,name:SNP,annots:SNP,Layout:Adaptive][key:SNP_Bins_track,name:Clinical Variants][key:SNP_Bins_track,name:Cited Variants][key:GWAS_track,name:GWAS Tracks,display_name:Association Results]" title="Nucleotide graphic report" ref="ordinalpos=1&ncbi_uid=&link_uid=NC_000013.11">Graphics</a> <a href="/nuccore/NC_000013.11?report=fasta&from=32302297&to=32413046" title="Nucleotide graphic report" ref="ordinalpos=1&ncbi_uid=&link_uid=NC_000013.11">FASTA</a> <a href="/nuccore/NC_000013.11?report=genbank&from=32302297&to=32413046" title="Nucleotide GenBank report" ref="ordinalpos=1&ncbi_uid=&link_uid=NC_000013.11">GenBank</a> </p><div id="divNC_000013" class="SeqViewerApp" style="clear:both;" data-sv="appname=ncbi-portal-gtr&embedded=true&noslider=1&id=NC_000013.11&from=32302297&to=32413046&tracks=[key:sequence_track,name:Sequence,display_name:Sequence,category:Sequence,annots:Sequence,ShowLabel:false][key:gene_model_track,name:Genes---Unnamed,display_name:Genes,annots:Unnamed,Options:MergePairs,SNPs:false,CDSProductFeats:true,ShowLabelsForAllFeatures:true,HighlightMode:2][key:feature_track,name:Genes---other,display_name:Genes - other,subkey:ncRNA,annots:other,Layout:Adaptive][key:feature_track,name:Genes---tRNA,display_name:Genes - tRNA,subkey:tRNA,annots:tRNA,Layout:Adaptive][key:SNP_track,name:SNP,annots:SNP,Layout:Adaptive][key:SNP_Bins_track,name:Clinical Variants][key:SNP_Bins_track,name:Cited Variants][key:GWAS_track,name:GWAS Tracks,display_name:Association Results]"><a href="?appname=ncbi-portal-gtr&embedded=true&noslider=1&id=NC_000013.11&from=32302297&to=32413046&tracks=[key:sequence_track,name:Sequence,display_name:Sequence,category:Sequence,annots:Sequence,ShowLabel:false][key:gene_model_track,name:Genes---Unnamed,display_name:Genes,annots:Unnamed,Options:MergePairs,SNPs:false,CDSProductFeats:true,ShowLabelsForAllFeatures:true,HighlightMode:2][key:feature_track,name:Genes---other,display_name:Genes - other,subkey:ncRNA,annots:other,Layout:Adaptive][key:feature_track,name:Genes---tRNA,display_name:Genes - tRNA,subkey:tRNA,annots:tRNA,Layout:Adaptive][key:SNP_track,name:SNP,annots:SNP,Layout:Adaptive][key:SNP_Bins_track,name:Clinical Variants][key:SNP_Bins_track,name:Cited Variants][key:GWAS_track,name:GWAS Tracks,display_name:Association Results]"></a></div></div></div><input name="nucleotideLink_NC_000013.11" sid="1" type="hidden" id="nucleotideLink_NC_000013_11_32315076_32400267" value="<p class="note-link"><strong class="margin_r1">Go to nucleotide</strong><a title="Nucleotide Graphic report" href="/nuccore/NC_000013.11?report=graph&amp;from=32302297&amp;to=32413046&amp;content=5" ref="ordinalpos=1&amp;ncbi_uid=&amp;link_uid=NC_000013.11">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NC_000013.11?report=fasta&amp;from=32315077&amp;to=32400268" ref="ordinalpos=1&amp;ncbi_uid=&amp;link_uid=NC_000013.11">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NC_000013.11?report=genbank&amp;from=32315077&amp;to=32400268" ref="ordinalpos=1&amp;ncbi_uid=&amp;link_uid=NC_000013.11">GenBank</a></p>" /><input name="relString_NC_000013.11" sid="1" type="hidden" id="relString_NC_000013_11_32315076_32400267" value="embedded=true&amp;noslider=1&amp;id=NC_000013.11&amp;from=32302297&amp;to=32413046&amp;content=5" /><input name="nucleotideLink_NG_012772.3" sid="1" type="hidden" id="nucleotideLink_NG_012772_3_5000_89192" value="<p class="note-link"><strong class="margin_r1">Go to nucleotide</strong><a title="Nucleotide Graphic report" href="/nuccore/NG_012772.3?report=graph&amp;from=1&amp;to=101821&amp;content=5" ref="ordinalpos=1&amp;ncbi_uid=&amp;link_uid=NG_012772.3">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NG_012772.3?report=fasta&amp;from=5001&amp;to=89193" ref="ordinalpos=1&amp;ncbi_uid=&amp;link_uid=NG_012772.3">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NG_012772.3?report=genbank&amp;from=5001&amp;to=89193" ref="ordinalpos=1&amp;ncbi_uid=&amp;link_uid=NG_012772.3">GenBank</a></p>" /><input name="relString_NG_012772.3" sid="1" type="hidden" id="relString_NG_012772_3_5000_89192" value="embedded=true&amp;noslider=1&amp;id=NG_012772.3&amp;from=1&amp;to=101821&amp;content=5" /><input name="nucleotideLink_NC_060937.1" sid="1" type="hidden" id="nucleotideLink_NC_060937_1_31532321_31617509" value="<p class="note-link"><strong class="margin_r1">Go to nucleotide</strong><a title="Nucleotide Graphic report" href="/nuccore/NC_060937.1?report=graph&amp;from=31519543&amp;to=31630287&amp;content=5" ref="ordinalpos=1&amp;ncbi_uid=&amp;link_uid=NC_060937.1">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NC_060937.1?report=fasta&amp;from=31532322&amp;to=31617510" ref="ordinalpos=1&amp;ncbi_uid=&amp;link_uid=NC_060937.1">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NC_060937.1?report=genbank&amp;from=31532322&amp;to=31617510" ref="ordinalpos=1&amp;ncbi_uid=&amp;link_uid=NC_060937.1">GenBank</a></p>" /><input name="relString_NC_060937.1" sid="1" type="hidden" id="relString_NC_060937_1_31532321_31617509" value="embedded=true&amp;noslider=1&amp;id=NC_060937.1&amp;from=31519543&amp;to=31630287&amp;content=5" /><input name="nucleotideLink_NC_000013.10" sid="1" type="hidden" id="nucleotideLink_NC_000013_10_32889213_32974404" value="<p class="note-link"><strong class="margin_r1">Go to nucleotide</strong><a title="Nucleotide Graphic report" href="/nuccore/NC_000013.10?report=graph&amp;from=32876434&amp;to=32987183&amp;content=5" ref="ordinalpos=1&amp;ncbi_uid=&amp;link_uid=NC_000013.10">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NC_000013.10?report=fasta&amp;from=32889214&amp;to=32974405" ref="ordinalpos=1&amp;ncbi_uid=&amp;link_uid=NC_000013.10">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NC_000013.10?report=genbank&amp;from=32889214&amp;to=32974405" ref="ordinalpos=1&amp;ncbi_uid=&amp;link_uid=NC_000013.10">GenBank</a></p>" /><input name="relString_NC_000013.10" sid="1" type="hidden" id="relString_NC_000013_10_32889213_32974404" value="embedded=true&amp;noslider=1&amp;id=NC_000013.10&amp;from=32876434&amp;to=32987183&amp;content=5" /></div></div><div id="variation"><h2>Variation</h2><div class="ui-ncbigrid-outer-div"><div class="ui-ncbigrid-inner-div"><table class="jig-ncbigrid" data-jigconfig=""><thead><tr><th>Resource</th><th>Links for this gene</th></tr></thead><tbody><tr><td>ClinVar</td><td><a href="/clinvar?LinkName=gene_clinvar&from_uid=675" ref="log$=recordlinks">Variants reported to ClinVar</a></td></tr><tr><td>dbVar</td><td><a href="/dbvar?LinkName=gene_dbvar&from_uid=675" ref="log$=recordlinks">Studies and variants</a></td></tr><tr><td>SNP</td><td><a href="https://www.ncbi.nlm.nih.gov/variation/view/?q=BRCA2%5bgenesymbol%5d&filters=source:dbsnp" ref="ncbi_uid=675">Variation Viewer for BRCA2 variants</a></td></tr><tr><td>Genome viewer</td><td><a href="https://www.ncbi.nlm.nih.gov/genome/gdv/?id=GSM923418,GSM923422,GSM923420&context=GEO&assm=GCF_000001405.25&q=BRCA2%5bgenesymbol%5d">Explore NCBI-annotated and select non-NCBI annotated genome assemblies</a></td></tr></tbody></table></div></div></div><div id="related-pubmed"><h2>Related articles in PubMed</h2><dl><dt><a href="/pubmed?LinkName=gene_pubmed_citedinomim&from_uid=675" ref="ncbi_uid=675&from=gtr_gene_related_pubmed_section" data-ga-label="pubmed_omim">PubMed-OMIM</a></dt><dd>publications in PubMed explicitly cited by the gene record in OMIM.
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</dd><dt><a href="/pubmed/clinical/?term=BRCA2" data-ga-label="pubmed_clinical">PubMed Clinical Queries</a></dt><dd>publications in PubMed limited specific clinical
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research.</dd><dt><a href="/pubmed/?LinkName=gene_pubmed&from_uid=675" data-ga-label="pubmed_all_related">All related articles in PubMed</a></dt><dd>sorted by relevance are shown below. <a href="/pubmed/?LinkName=gene_pubmed&from_uid=675" data-ga-label="pubmed_all_related">Click to see all (2201) citations.</a></dd></dl><div class="generefbl-link"><ol class="generef-link"><li><a href="/pubmed/17700570/" ref="ncbi_uid=675&link_uid=17700570" data-ga-label="pubmed_article">Rare germline mutations in the BRCA2 gene are associated with early-onset prostate cancer.</a><span class="pubmed-auth-date"><br />Agalliu I, Karlins E, Kwon EM, Iwasaki LM, Diamond A, Ostrander EA, Stanford JLAgalliu I, <em>et al</em>. Br J Cancer, 2007 Sep 17. PMID 17700570</span></li><li><a href="/pubmed/28870368/" ref="ncbi_uid=675&link_uid=28870368" data-ga-label="pubmed_article">Pancreatic Ductal Adenocarcinoma.</a><span class="pubmed-auth-date"><br />Erickson LAErickson LA. Mayo Clin Proc, 2017 Sep. PMID 28870368</span></li><li><a href="/pubmed/28893223/" ref="ncbi_uid=675&link_uid=28893223" data-ga-label="pubmed_article">BRCA2 carriers with male breast cancer show elevated tumour methylation.</a><span class="pubmed-auth-date"><br />Deb S, Gorringe KL, Pang JB, Byrne DJ, Takano EA, kConFab Investigators, Dobrovic A, Fox SBDeb S, <em>et al</em>. BMC Cancer, 2017 Sep 11. PMID 28893223</span></li><li><a href="/pubmed/28982360/" ref="ncbi_uid=675&link_uid=28982360" data-ga-label="pubmed_article">Association between single nucleotide polymorphism rs9534275 and the risk of coronary artery disease and ischemic stroke.</a><span class="pubmed-auth-date"><br />Miao L, Yin RX, Yang S, Huang F, Chen WX, Cao XLMiao L, <em>et al</em>. Lipids Health Dis, 2017 Oct 5. PMID 28982360</span></li><li><a href="/pubmed/18214034/" ref="ncbi_uid=675&link_uid=18214034" data-ga-label="pubmed_article">A BRCA2 mutation, 4088insA, in a Finnish breast and ovarian cancer family associated with favourable clinical course.</a><span class="pubmed-auth-date"><br />Hartikainen JM, Mannermaa A, Heinonen S, Kosma VM, Kataja VHartikainen JM, <em>et al</em>. Anticancer Res, 2007 Nov-Dec. PMID 18214034</span></li></ol></div></div></div>
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