698 lines
57 KiB
HTML
698 lines
57 KiB
HTML
<?xml version="1.0" encoding="utf-8"?>
|
||
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
|
||
<html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en" lang="en">
|
||
|
||
<head><meta http-equiv="Content-Type" content="text/html; charset=utf-8" />
|
||
<!-- AppResources meta begin -->
|
||
<meta name="paf-app-resources" content="" />
|
||
<!-- AppResources meta end -->
|
||
|
||
<!-- TemplateResources meta begin -->
|
||
<meta name="paf_template" content="StdNCol" />
|
||
|
||
<!-- TemplateResources meta end -->
|
||
|
||
<!-- Page meta begin -->
|
||
|
||
<!-- Page meta end -->
|
||
|
||
<!-- Logger begin -->
|
||
<meta xmlns:ncbi-portal="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" name="ncbi_app" content="gtr" /><meta xmlns:ncbi-portal="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" name="ncbi_pdid" content="static" />
|
||
<!-- Logger end -->
|
||
|
||
<title>GTR Submission Documents</title>
|
||
|
||
<!-- PageFixtures headcontent begin -->
|
||
<meta content="gtr" name="ncbi_db" /><meta content="index, follow, noarchive" name="robots" /><meta content="IE=edge,chrome=1" http-equiv="X-UA-Compatible" />
|
||
|
||
<meta name="cms-local-nav-url" content="https://cms.ncbi.nlm.nih.gov///gtr/help_docs_nav" />
|
||
|
||
<!-- PageFixtures headcontent end -->
|
||
|
||
<!-- AppResources external_resources begin -->
|
||
<script type="text/javascript" src="/core/jig/1.15.6/js/jig.min.js"></script>
|
||
|
||
<!-- AppResources external_resources end -->
|
||
|
||
<!-- Page headcontent begin -->
|
||
<meta name="subsite" content="gtr" />
|
||
<meta name="path" content="gtr/docs/submission" />
|
||
<meta name="modified" content="2018-04-06T20:42:15Z" />
|
||
<link type="text/css" rel="stylesheet" href="/core/assets/gtr/css/feedback_css.css" />
|
||
<link type="text/css" rel="stylesheet" href="/core/assets/gtr/css/gtr_cms.css" />
|
||
<link type="text/css" rel="stylesheet" href="/core/assets/gtr/css/main.css" />
|
||
<!-- Page headcontent end -->
|
||
<!-- PageFixtures resources begin -->
|
||
<link xmlns="http://www.w3.org/1999/xhtml" type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4218191/css/4207974/4206132.css" xml:base="http://127.0.0.1/sites/static/header_footer" />
|
||
|
||
<!-- PageFixtures resources end -->
|
||
<link rel="shortcut icon" href="//www.ncbi.nlm.nih.gov/favicon.ico" /><meta name="ncbi_phid" content="CE8C0B7B7C7F4D5100000000011200D3.m_10" />
|
||
<meta name='referrer' content='origin-when-cross-origin'/><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4221774/css/4121862/3974050/3917732/251717/4171260/14534/45193/3534283/4128070/4003311/4005757/4110101/4173824.css" /><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4221774/css/3529741.css" media="print" /></head>
|
||
<body class=" static">
|
||
<div class="grid">
|
||
<div class="col twelve_col nomargin shadow">
|
||
<!-- System messages like service outage or JS required; this is handled by the TemplateResources portlet -->
|
||
<div class="sysmessages">
|
||
<noscript>
|
||
<p class="nojs">
|
||
<strong>Warning:</strong>
|
||
The NCBI web site requires JavaScript to function.
|
||
<a href="/guide/browsers/#enablejs" title="Learn how to enable JavaScript" target="_blank">more...</a>
|
||
</p>
|
||
</noscript>
|
||
</div>
|
||
<!--/.sysmessage-->
|
||
<div class="wrap">
|
||
<div class="page">
|
||
<div xmlns:xi="http://www.w3.org/2001/XInclude">
|
||
<div xmlns="http://www.w3.org/1999/xhtml" id="universal_header" xml:base="http://127.0.0.1/sites/static/header_footer">
|
||
<section class="usa-banner">
|
||
<div class="usa-accordion">
|
||
<header class="usa-banner-header">
|
||
<div class="usa-grid usa-banner-inner">
|
||
<img src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png" alt="U.S. flag" />
|
||
<p>An official website of the United States government</p>
|
||
<button class="non-usa-accordion-button usa-banner-button" aria-expanded="false" aria-controls="gov-banner-top" type="button">
|
||
<span class="usa-banner-button-text">Here's how you know</span>
|
||
</button>
|
||
</div>
|
||
</header>
|
||
<div class="usa-banner-content usa-grid usa-accordion-content" id="gov-banner-top" aria-hidden="true">
|
||
<div class="usa-banner-guidance-gov usa-width-one-half">
|
||
<img class="usa-banner-icon usa-media_block-img" src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg" alt="Dot gov" />
|
||
<div class="usa-media_block-body">
|
||
<p>
|
||
<strong>The .gov means it's official.</strong>
|
||
<br />
|
||
Federal government websites often end in .gov or .mil. Before
|
||
sharing sensitive information, make sure you're on a federal
|
||
government site.
|
||
</p>
|
||
</div>
|
||
</div>
|
||
<div class="usa-banner-guidance-ssl usa-width-one-half">
|
||
<img class="usa-banner-icon usa-media_block-img" src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg" alt="Https" />
|
||
<div class="usa-media_block-body">
|
||
<p>
|
||
<strong>The site is secure.</strong>
|
||
<br />
|
||
The <strong>https://</strong> ensures that you are connecting to the
|
||
official website and that any information you provide is encrypted
|
||
and transmitted securely.
|
||
</p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
<div class="usa-overlay"></div>
|
||
<header class="ncbi-header" role="banner" data-section="Header">
|
||
|
||
<div class="usa-grid">
|
||
<div class="usa-width-one-whole">
|
||
|
||
<div class="ncbi-header__logo">
|
||
<a href="/" class="logo" aria-label="NCBI Logo" data-ga-action="click_image" data-ga-label="NIH NLM Logo">
|
||
<img src="https://www.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg" alt="NIH NLM Logo" />
|
||
</a>
|
||
</div>
|
||
|
||
<div class="ncbi-header__account">
|
||
<a id="account_login" href="https://account.ncbi.nlm.nih.gov" class="usa-button header-button" style="display:none" data-ga-action="open_menu" data-ga-label="account_menu">Log in</a>
|
||
<button id="account_info" class="header-button" style="display:none" aria-controls="account_popup" type="button">
|
||
<span class="fa fa-user" aria-hidden="true">
|
||
<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" width="20px" height="20px">
|
||
<g style="fill: #fff">
|
||
<ellipse cx="12" cy="8" rx="5" ry="6"></ellipse>
|
||
<path d="M21.8,19.1c-0.9-1.8-2.6-3.3-4.8-4.2c-0.6-0.2-1.3-0.2-1.8,0.1c-1,0.6-2,0.9-3.2,0.9s-2.2-0.3-3.2-0.9 C8.3,14.8,7.6,14.7,7,15c-2.2,0.9-3.9,2.4-4.8,4.2C1.5,20.5,2.6,22,4.1,22h15.8C21.4,22,22.5,20.5,21.8,19.1z"></path>
|
||
</g>
|
||
</svg>
|
||
</span>
|
||
<span class="username desktop-only" aria-hidden="true" id="uname_short"></span>
|
||
<span class="sr-only">Show account info</span>
|
||
</button>
|
||
</div>
|
||
|
||
<div class="ncbi-popup-anchor">
|
||
<div class="ncbi-popup account-popup" id="account_popup" aria-hidden="true">
|
||
<div class="ncbi-popup-head">
|
||
<button class="ncbi-close-button" data-ga-action="close_menu" data-ga-label="account_menu" type="button">
|
||
<span class="fa fa-times">
|
||
<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 48 48" width="24px" height="24px">
|
||
<path d="M38 12.83l-2.83-2.83-11.17 11.17-11.17-11.17-2.83 2.83 11.17 11.17-11.17 11.17 2.83 2.83 11.17-11.17 11.17 11.17 2.83-2.83-11.17-11.17z"></path>
|
||
</svg>
|
||
</span>
|
||
<span class="usa-sr-only">Close</span></button>
|
||
<h4>Account</h4>
|
||
</div>
|
||
<div class="account-user-info">
|
||
Logged in as:<br />
|
||
<b><span class="username" id="uname_long">username</span></b>
|
||
</div>
|
||
<div class="account-links">
|
||
<ul class="usa-unstyled-list">
|
||
<li><a id="account_myncbi" href="/myncbi/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_myncbi">Dashboard</a></li>
|
||
<li><a id="account_pubs" href="/myncbi/collections/bibliography/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_pubs">Publications</a></li>
|
||
<li><a id="account_settings" href="/account/settings/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_settings">Account settings</a></li>
|
||
<li><a id="account_logout" href="/account/signout/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_logout">Log out</a></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
</header>
|
||
<div role="navigation" aria-label="access keys">
|
||
<a id="nws_header_accesskey_0" href="https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys" class="usa-sr-only" accesskey="0" tabindex="-1">Access keys</a>
|
||
<a id="nws_header_accesskey_1" href="https://www.ncbi.nlm.nih.gov" class="usa-sr-only" accesskey="1" tabindex="-1">NCBI Homepage</a>
|
||
<a id="nws_header_accesskey_2" href="/myncbi/" class="set-base-url usa-sr-only" accesskey="2" tabindex="-1">MyNCBI Homepage</a>
|
||
<a id="nws_header_accesskey_3" href="#maincontent" class="usa-sr-only" accesskey="3" tabindex="-1">Main Content</a>
|
||
<a id="nws_header_accesskey_4" href="#" class="usa-sr-only" accesskey="4" tabindex="-1">Main Navigation</a>
|
||
</div>
|
||
<section data-section="Alerts">
|
||
<div class="ncbi-alerts-placeholder"></div>
|
||
</section>
|
||
</div>
|
||
</div>
|
||
<!--/.header-->
|
||
<div class="header">
|
||
|
||
<div class="gtr_logo"><a href="/gtr" title="Genetic Testing Registry">NIH Genetic Testing Registry</a></div>
|
||
<div><div class="header_con2"><div id="searchBox" class="smallSearchBox"><form id="formSearch" data-selected-scope="docs" action="https://www.ncbi.nlm.nih.gov/gtr/" method="get"><div class="formFields noWrap"><label for="gtr_term" class="ui-helper-hidden-accessible">Search term</label><input id="gtr_term" name="term" type="text" data-jig="ncbiautocomplete" value="all[sb]" data-jigconfig="maxListLimit: 15" data-dictionary="gtr_allgtr" /><select name="scope" class="scope_sel" id="scope"><option value="gtr">All GTR</option><option value="conditions">Conditions/Phenotypes</option><option value="genes">Genes</option><option value="tests">Human Tests</option><option value="testsmicrobe">Microbe Tests</option><option value="labs">Labs</option></select><button type="submit" id="submitSearchButton" class="gtr-button-submit ui-ncbibutton-blue">Search</button><a href="/gtr/tests/advanced/" id="go-to-advanced-search">Advanced search for tests</a></div></form></div></div></div>
|
||
|
||
|
||
|
||
</div>
|
||
<div class="nav_and_browser">
|
||
<div class="localnav"><ul class="jig-ncbilocalnav">
|
||
<li><a href="#">Overview</a><ul>
|
||
<li><a href="/gtr/docs/about/">About GTR</a></li>
|
||
<li><a title="Submission overview" href="/gtr/docs/submit/">Submission to GTR</a></li>
|
||
<li><a title="Resources included in GTR and where to locate a genetics professional" href="/gtr/docs/resources/">GTR resources</a></li>
|
||
<li><a title="Frequently asked questions" href="/gtr/docs/faq/">FAQ</a></li>
|
||
<li><a href="https://www.nih.gov/institutes-nih/nih-office-director">NIH Office of the Director</a></li>
|
||
<li><a href="/gtr/docs/outreach/">Community outreach</a></li>
|
||
<li><a href="/gtr/docs/maintenance_use/">Data use and maintenance</a></li>
|
||
<li><a href="/clinvar/nomenclature/">Terminology</a></li>
|
||
<li><a href="/gtr/docs/linkcriteria/">Web link criteria</a></li>
|
||
<li><a href="/gtr/docs/linking/">How to create links to GTR</a></li>
|
||
</ul>
|
||
</li>
|
||
<li><a href="#">Lab Submission</a><ul>
|
||
<li><a href="/gtr/docs/login/">Login</a></li>
|
||
<li><a title="Overview of how to submit novel laboratory information" href="/gtr/docs/submit/add_lab/">Register a new lab</a></li>
|
||
<li><a title="Instructions for performing the annual review" href="/gtr/docs/annual_review/">Annual review</a></li>
|
||
<li><a title="Instructions for managing the group account for submitters" href="/gtr/docs/manage_permissions/">Groups: Manage person permissions</a></li>
|
||
<li><a title="Instructions for submitters about updating and deleting records" href="/gtr/docs/manage_records/">Manage records</a></li>
|
||
</ul>
|
||
</li>
|
||
<li><a href="#">Genetic Test Submission</a><ul>
|
||
<li><a title="Overview of genetic test submissions" href="/gtr/docs/submit/">Getting started</a></li>
|
||
<li><a title="Instructions for clinical genetic test submissions" href="/gtr/docs/submit/add_test/">Clinical tests</a></li>
|
||
<li><a title="Instructions for spreadsheet submissions for clinical genetic tests" href="/gtr/docs/fulltest/">Clinical tests by spreadsheet</a></li>
|
||
<li><a title="Instructions for API submissions for clinical genetic tests" href="/gtr/docs/gtr_api_http/">Clinical tests by api</a></li>
|
||
<li><a title="Instructions for research genetic test submissions" href="/gtr/docs/submit/add_research/">Research tests</a></li>
|
||
</ul>
|
||
</li>
|
||
<li><a href="#">Microbe Test Submission</a><ul>
|
||
<li><a title="Overview of microbe test submissions" href="/gtr/docs/microbe_test/">Getting started</a></li>
|
||
<li><a title="Instructions for clinical microbe test submissions" href="/gtr/docs/submit/add_microbe_clinical/">Clinical tests</a></li>
|
||
<li><a title="Instructions for spreadsheet submissions for clinical microbe tests" href="/gtr/docs/microbe_fulltest/">Clinical tests by spreadsheet</a></li>
|
||
<li><a title="Instructions for API submissions for clinical microbe tests" href="/gtr/docs/gtr_api_http/">Clinical tests by api</a></li>
|
||
<li><a title="Instructions for research microbe test submissions" href="/gtr/docs/submit/add_microbe_research/">Research tests</a></li>
|
||
</ul>
|
||
</li>
|
||
<li><a href="#">Search GTR</a><ul>
|
||
<li><a title="How to use and search the GTR website" href="/gtr/docs/help/">Search tips</a></li>
|
||
<li><a href="/gtr/docs/advanced_search">Advanced search</a></li>
|
||
<li><a href="/gtr/docs/common_searches/">Common searches</a></li>
|
||
<li><a href="https://www.youtube.com/playlist?list=PL7dF9e2qSW0a1b37gVee-pYFZ4AEOGvqw">YouTube library</a>
|
||
<span id="shared-content-1"></span></li>
|
||
</ul>
|
||
</li>
|
||
</ul></div>
|
||
</div>
|
||
|
||
<!-- was itemctrl -->
|
||
<div class="container">
|
||
<div id="maincontent" class="content col twelve_col last">
|
||
<div class="col1">
|
||
<div>
|
||
<div id="static-page-tools">
|
||
<div style="display:inline-block;">
|
||
<form id="form-helpdocs" action="/gtr/docs/" method="get">
|
||
<label class="ui-helper-hidden-accessible" for="helpdocs-search-term">Search GTR Help Documents</label>
|
||
<input autocomplete="off" value="" placeholder="Search GTR Help Documents" name="term" id="helpdocs-search-term" style="width:30em;" />
|
||
<button id="search">Search GTR help documents</button>
|
||
</form>
|
||
</div>
|
||
<ul>
|
||
<li class="print">
|
||
<a href="#" id="print-this" title="Print this document">Print this document</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
<div class="print-all">
|
||
|
||
<div>
|
||
<p><span class="br_text"><a href="/gtr/">GTR Home</a> </span> <span class="br_sep"> > </span> <span class="br_text"> <a href="/gtr/">GTR Help</a> </span> <span class="br_sep"> > </span> <span class="br_text"><a href="/gtr/docs/submission/">Submission</a></span> <span class="br_sep"> > </span> <span class="br_text">Submission Overview</span></p><div class="fl_right">
|
||
<div><div><b>OMB NO: 0925-0651</b></div><div><b>EXPIRATION DATE: 01/31/2025</b>*</div><div><a href="/gtr/docs/omb_approval/">Burden Statement</a></div><div style="font-size: 0.9em;">* Renewal in process</div></div>
|
||
</div><div class="title_sec">
|
||
<h1 id="title_sec">The GTR Submission Process</h1>
|
||
</div><p>This document is an overview of the methods by which information can be registered in the GTR. Detailed information is provided in specific pages that can be accessed from the navigation menu above. </p><p>You can access a webinar about registering with GTR which will help you determine a submission strategy for your laboratory <a href="/gtr/docs/outreach/#ampwebinar">here</a>.</p><p>Table of contents</p><div class="toc">
|
||
<ul>
|
||
<li><a href="#tests">What constitutes a test in the GTR?</a></li>
|
||
<li><a href="#types">What types of tests are currently accepted?</a></li>
|
||
<li><a href="#data">What data should be collected before submitting?</a></li>
|
||
<li><a href="#submission">Submission scenarios</a><ul>
|
||
<li><a href="#scenarios">Scenarios for test submissions</a></li>
|
||
</ul>
|
||
</li>
|
||
<li><a href="#start">How do I get started?</a></li>
|
||
<li><a href="#who">Who is authorized to submit?</a></li>
|
||
<li><a href="#overview">Overview of the steps to register labs and tests</a></li>
|
||
<li><a href="#conventions">Conventions used in the interactive submission interface</a></li>
|
||
<li><a href="#homepage">Your submission home page</a></li>
|
||
<li><a href="#adding-tests">Adding tests</a></li>
|
||
<li><a href="#update">How to manage your records in the GTR</a></li>
|
||
<li><a href="#data_use">How are my data used by NCBI?</a></li>
|
||
<li><a href="#gtr-api-submissions">GTR API Submissions</a></li>
|
||
</ul>
|
||
</div><h2 id="tests">What constitutes a test in the GTR?</h2><p>A clinical test in the GTR is defined as the equivalent of a laboratory order code. The definition of a clinical genetic test in the GTR may be found <a href="/gtr/docs/about/">here</a>.</p><p>A research test in the GTR is defined as <span>a test that is performed for the purpose of contributing to generalizable knowledge or for a laboratory to generate data in order to make technical improvements to a test.</span></p><h2 id="types">What types of tests are currently accepted?</h2><p>GTR is now accepting registration of clinical and research tests. Tests may be registered for Mendelian disorders, somatic conditions (such as cancer), complex tests and arrays, and pharmacogenetic tests, as well as for microbe tests that affect human health and disease. These tests may include multiple methods and may include multiple major method categories such as biochemical, cytogenetic, and molecular tests.</p><p>GTR is not currently accepting registration of direct-to-consumer tests. </p><p>Tests that are general and not specific to a particular condition, set of conditions or genes, or chromosomal structures are categorized by GTR as <a href="/gtr/docs/submit/lab_info/#services">Laboratory services</a> and will be entered in the laboratory record. One such example is Preimplantation Genetic Diagnosis (PGD). Whole exome sequencing and whole genome sequencing are considered to be tests in GTR, but are not yet in scope as fully described tests. These may now be entered as Laboratory services, with the opportunity to provide information in a comment box, and at a later phase they will be registered as tests.</p><p>Tests which are performed entirely at an outside lab/facility (send-outs) should not be registered in GTR. 'Outside' means a lab/facility that is not covered by your lab's CLIA certification, even if both labs have the same parent organization.</p><h2 id="data">What data should be collected before submitting?</h2><p>The list of data elements that may be submitted is provided in GTR's Data Dictionary (<a href="https://ftp.ncbi.nlm.nih.gov/pub/GTR/documentation/GTRFieldDefinitions.pdf">pdf</a> or <a href="https://ftp.ncbi.nlm.nih.gov/pub/GTR/documentation/GTRFieldDefinitions.docx">Word</a>. These elements are categorized as minimal, recommended, and optional. Minimal fields are required, and submission will fail if not supplied. Recommended elements are not required, and can be skipped in the submission process. The web interface will, however, report 'not provided' for blank recommended fields. Optional fields are not required, and can be skipped in the submission process. The web interface will not display optional fields left blank.</p><h2 id="submission">Submission scenarios</h2><p>Registration in GTR is divided into two major categories:</p><ol>
|
||
<li>
|
||
<p>Laboratory registration </p>
|
||
<ul>
|
||
<li>Laboratory and personnel data that are applicable to all tests are entered once. </li>
|
||
<li>All laboratory registrations are performed through the interactive web-based submission user interface.</li>
|
||
<li>The 'Default parameters' tab enables the entry of information that is shared by most tests offered by the lab. Information supplied in this tab will pre-populate test records for later review and editing, potentially saving keystrokes.</li>
|
||
</ul>
|
||
</li>
|
||
<li>
|
||
<p>Test registration </p>
|
||
<ul>
|
||
<li>Submission of test-specific information, where a clinical test is defined as the equivalent of an order code and a research test is either a component of a research study or a test undergoing technical improvements.</li>
|
||
</ul>
|
||
</li>
|
||
</ol><h3 id="scenarios">Scenarios for test submissions</h3><ol>
|
||
<li>
|
||
<p><em>Completely interactive</em>:<br />
|
||
The submitter enters and reviews information via web-based forms. New clinical and research tests can be created by any lab registered in GTR.</p>
|
||
</li>
|
||
<li>
|
||
<p><em>Automatic submission using the GTR test submission template with complete set of fields (for clinical tests only):</em><br />
|
||
The submitter downloads a test submission template file from their lab overview page or or from the <a href="https://ftp.ncbi.nlm.nih.gov/pub/GTR/submission_templates/" class="file">FTP site</a> which supports entry of all test fields. The submitter completes the spreadsheet for each test the lab wishes to register. Once successfully uploaded, the tests are automatically registered. Read more about this mode of submission <a href="/gtr/docs/fulltest/">for clinical genetic tests</a> and <a href="/gtr/docs/microbe_fulltest/">clinical microbe tests</a>.</p>
|
||
</li>
|
||
<li>
|
||
<p><em>Semi-automatic submission using the GTR test submission template with minimal set of fields (for clinical genetic tests only):</em><br />
|
||
The submitter downloads a test submission template file from their lab overview page or from the <a href="https://ftp.ncbi.nlm.nih.gov/pub/GTR/submission_templates/" class="file">FTP site</a> which supports entry of all required test fields and certain recommended fields. <br />
|
||
The submitter completes the spreadsheet for each test the lab wishes to register. The submitter uses the interactive submission interface to review each record seeded by the spreadsheet, enters information as desired for any recommended and optional fields not supported by the spreadsheet, and submits each test. Read more about this mode of submission <a href="/gtr/docs/submit/semiautomatic/">here</a>.</p>
|
||
</li>
|
||
<li>
|
||
<p><em>Completely automatic:</em><br />
|
||
GTR now supports submission of clinical tests, both clinical genetic tests and clinical microbe tests, via a RESTful (REpresentational State Transfer) API (Application Programming Interface). Data submission and the status response are in JSON (JavaScript Object Notation) data exchange format. The <a href="/gtr/docs/gtr_api_http/">documentation</a> includes the submission and response schemas, as well as helpful information to guide submitters. <a href="mailto:tkt-tryhd@ncbi.nlm.nih.gov?subject=Create%20a%20GTR%20API%20service%20account">Contact GTR staff</a> to create a service account and get started.</p>
|
||
</li>
|
||
</ol><h2 id="start">How do I get started?</h2><p>The GTR help site includes multiple documents about registering laboratories and tests, with some specific and distinctive aspects of the submission/update process. The navigation menu at the top of the page provides menus from which to select the page specific to your topic of choice. Details about each tab are provided in the <a href="#list">table below</a>.</p><p>Laboratory information must be entered first. New laboratories have a wait period of 2-3 business days for GTR staff to review the laboratory record. Test information laboratory can be entered only after the laboratory has been registered in the GTR.</p><p>To determine whether your Web browser is supported to run NCBI web applications including data submission, use this link: <a href="/guide/browsers">Browser Advice for NCBI Web Pages</a></p><h2 id="who">Who is authorized to submit?</h2><p>Initially one person per lab can submit lab and test data to GTR.</p><p>We have enabled submissions from multiple individuals from a single lab in a function called <a href="/gtr/docs/manage_permissions/">Groups</a>. Please contact us if this is a feature you would like to use.</p><h2 id="overview">Overview of the steps to register labs and tests</h2><ol>
|
||
<li>Go to the <a href="https://submit.ncbi.nlm.nih.gov/subs/gtr">GTR Submission user interface</a></li>
|
||
<li><a href="/gtr/docs/login/">Login</a> to the GTR submission site</li>
|
||
<li><a href="/gtr/docs/submit/add_lab/">Create a lab record</a>: log in to the submission interface and proceed through the steps below, then click the Add a new lab button. Once you submit your lab, you will receive an email informing you your information was submitted. GTR staff will review the information and must approve your lab before you can register your tests. This process may take 2-3 business days. We may contact the lab if more information is needed. When your lab is approved, you will receive a notification email informing you that you can register your tests.</li>
|
||
<li>Once you have an active laboratory record, create new test records, review the information and submit the records interactively.</li>
|
||
<li>If you have many clinical tests to register, you can consider submitting data to GTR in bulk via the full test submission spreadsheet.</li>
|
||
</ol><h2 id="conventions">Conventions used in the interactive submission interface</h2><ul>
|
||
<li><strong>Orange asterisk (<span>*</span>):</strong> minimal field, the submission will fail if the data are not supplied</li>
|
||
<li><strong>?(<img src="/core/icons/help.png" alt="help icon" />) icon:</strong> hover over icon to display an instruction tip</li>
|
||
<li><strong>Information will display on the public site exactly as it is entered</strong>, unless otherwise noted. Therefore, please note carefully the recommended format for fields and be careful to spell out information the way you want the public to see it.</li>
|
||
<li><strong>Phone numbers</strong> require a specific format (<em>e.g.</em> US phone numbers should be entered as 123-456-7890 ext. 1234).</li>
|
||
<li><strong>URLs (websites)</strong> must begin with the protocol (<em>e.g</em>. http://, https://, or ftp://).</li>
|
||
</ul><h2 id="homepage">Your submission home page</h2><p>When you have established your account, you will be presented with your <a href="https://submit.ncbi.nlm.nih.gov/subs/gtr">GTR Submission home page</a>. This page supports the functions of adding, deleting and editing data. When you have completed a submission, it also displays what you have submitted and the status of each submission. For example, when you login to the GTR submission interface for the first time and accept the code of conduct, this is what you will see. Note the link to these help documents, and the address to contact GTR staff by email.</p><p>Your name anchors the link to your profile page. That profile page also has a submissions tab where you can review your submissions.</p><p><img src="/core/assets/gtr/images/submission_home_new.png" alt="Display of a submission home page for a new registrant" /></p><p>Once you have started to process some information, the page will provide a summary, separated by laboratory, of the submission you have initiated. You can click on the link (<strong>Review lab submission</strong> or <strong>Edit this lab</strong>, the latter if the lab record has not been submitted) to view / edit the lab record. Please <a href="mailto:tkt-tryhd@ncbi.nlm.nih.gov?subject=Question%20about%20deleting%20lab%20or%20test%20data%20from%20GTR">contact GTR staff</a> if you need to delete your laboratory from the GTR.</p><p><img src="/core/assets/gtr/images/submission_home_new2.png" alt="Display of a submission home page after adding a lab" /></p><p>Once a lab has submitted test information, you can view your tests using the <a href="/gtr/docs/test_management/">test management page</a>.</p><h2 add_tests="add_tests" id="adding-tests">Adding tests</h2><p>Detailed instructions are shown on the following pages: </p><ul>
|
||
<li>Using the submission wizard<ul>
|
||
<li>Genetic tests <ul>
|
||
<li><a href="/gtr/docs/submit/add_test">Clinical</a></li>
|
||
<li><a href="/gtr/docs/submit/add_research">Research</a></li>
|
||
</ul>
|
||
</li>
|
||
<li>Microbe tests<ul>
|
||
<li><a href="/gtr/docs/submit/add_microbe_clinical">Clinical</a></li>
|
||
<li><a href="/gtr/docs/submit/add_microbe_research">Research</a></li>
|
||
</ul>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
<li>Using the spreadsheet templates<ul>
|
||
<li>Genetic tests (clinical only)<ul>
|
||
<li><a href="/gtr/docs/fulltest">All clinical fields spreadsheet submission</a>; once the spreadsheet is uploaded, test submission is automatic; we encourage submitters to use this spreadsheet </li>
|
||
<li><a href="/gtr/docs/submit/semiautomatic">Minimal clinical fields spreadsheet submission</a>; note that this method is semiautomated; the submitter will need to submit each test manually using the submission wizard once the spreadsheet has been uploaded and processed.</li>
|
||
</ul>
|
||
</li>
|
||
<li>Microbe tests (clinical only) <ul>
|
||
<li><a href="/gtr/docs/microbe_fulltest">All clinical fields spreadsheet submission</a></li>
|
||
</ul>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
</ul><h2 id="update">How to manage your records in the GTR</h2><p>See <a href="/gtr/docs/manage_records/">detailed instructions</a> on how to update, delete, copy and edit GTR records.</p><h2 id="data_use">How are my data used by NCBI?</h2><p>The data you submit will be displayed publicly in GTR and may be reflected in other NCBI resources such as <a href="/medgen/">MedGen</a> and <a href="/clinvar/">ClinVar</a>. Exceptions to submitted information that will be displayed publicly, such as private comments to GTR staff and private contact information are marked in the submission user interface and in the help documentation. Please do not submit any data that you consider to be proprietary.</p><p>When your submission includes information about the alleles you test for a disorder, your data will be accessioned in ClinVar as well (<a href="https://www.ncbi.nlm.nih.gov/clinvar">http://www.ncbi.nlm.nih.gov/clinvar</a>). We therefore encourage you to provide information about the clinical significance of each allele. By combining efforts, GTR and ClinVar hope to improve access to information about medically important variation.</p><h2 id="gtr-api-submissions">GTR API Submissions</h2><p>For fully automated submission of GTR clinical tests, both genetic tests and microbe tests, see <a href="/gtr/docs/gtr_api_http/">GTR Submission API</a>.</p><p><span id="shared-content-1"></span></p>
|
||
</div>
|
||
|
||
<div>
|
||
<div class="fl_right">
|
||
<div><div><b>OMB NO: 0925-0651</b></div><div><b>EXPIRATION DATE: 01/31/2025</b>*</div><div><a href="/gtr/docs/omb_approval/">Burden Statement</a></div><div style="font-size: 0.9em;">* Renewal in process</div></div>
|
||
</div><div class="title_sec">
|
||
<h1 id="login-to-the-submission-portal">Login to the Submission Portal</h1>
|
||
</div><p>This document describes how to establish access to submit data to NCBI, specifically GTR. You are responsible for maintaining the integrity and security of your data by following the instructions here.</p><p>Submission of data to GTR entails following these steps:</p><ol>
|
||
<li><a href="#connect">Connect to the GTR submission site</a> which is located here: <a href="https://submit.ncbi.nlm.nih.gov/subs/gtr/">https://submit.ncbi.nlm.nih.gov/subs/gtr</a></li>
|
||
<li><a href="#login">Login</a></li>
|
||
<li><a href="#Update">Update your profile</a> (Important and required!)</li>
|
||
<li><a href="#code">Read and accept the Code of Conduct</a></li>
|
||
<li><a href="#integrity">Do not share login credentials between individuals</a></li>
|
||
</ol><h2 id="connect">Connect to the GTR submission site</h2><p>The GTR submission site is part of NCBI's unified submission interface: <a href="https://submit.ncbi.nlm.nih.gov/subs/gtr/">https://submit.ncbi.nlm.nih.gov/subs/gtr/</a>. The tools in this interface are being established for all submissions to NCBI. When you connect to this site, it should look like this. Note the link to the login interface at the upper right.</p><p><img src="/core/assets/gtr/images/login1.PNG" alt="GTR Submission Login Screen" class="img-border" /></p><h2 id="login">Logging in</h2><p>Login to the Submission Portal using NIH login or third-party login credentials. You can also use your My NCBI account credentials to log in but there are upcoming changes to My NCBI accounts. See the <a href="https://ncbiinsights.ncbi.nlm.nih.gov/ncbi-login-retirement-faqs/">NCBI Account Login Changes FAQs</a>.</p><h2 id="Update">Update your profile</h2><p>Most likely you will be using NCBI's submission interface for the first time. If so, your screen will look like this:</p><p><img src="/core/assets/gtr/images/SP_profile_warning.png" alt="Warning to enter first and last name on GTR submission portal" /></p><p>Once logged in, new users must provide contact information so that we know who you are and can contact you easily if a problem arises in your submission. Please click on the 'My profile' link and carefully follow the instructions in the next image.</p><p><img src="/core/assets/gtr/images/CompletePersonalInformation.png" alt="Complete first and last name" /></p><p>Complete your profile.<br />
|
||
You will be presented with a form like the one above. Please note the following:</p><ol>
|
||
<li>When you update your profile, <strong>you must submit your first and last name</strong>. Completing this information as part of your laboratory submission does not fulfill the requirement to enter it here.</li>
|
||
<li>We highly recommend you <strong>leave this box checked</strong> - Send email notifications on submission status change - so you will be notified when your submission is processed. You may enter other contact details, but be advised that as a data submitter we will be asking for those data again when you process your laboratory's data.<br />
|
||
<strong>NOTE</strong>: Country field must be completed. For U.S., State must be provided.</li>
|
||
<li>Click Save.</li>
|
||
<li>If you are not automatically taken to a new page, click the Home tab at the top of the page or the gray area labelled Submission Portal in the upper left-hand corner.</li>
|
||
</ol><p>After completing the login process you will be presented with the Code of Conduct.</p><p>After clicking on the Home tab, you will see this page. Scroll down to the section <em>Medical Genetics and Variation Tools</em> and click on GTR.
|
||
<img src="/core/assets/gtr/images/SP-Home-Page-Login.png" alt="Click on GTR" />
|
||
<img src="/core/assets/gtr/images/SP-Home-Page-Click-on-GTR.png" alt="Click on GTR" /></p><h2 id="code">Code of Conduct</h2><p>When your login is successful, you will be presented with the GTR Code of Conduct. You must read and click I agree to be able to register in the GTR. This screen will not be presented again after you have accepted it. After successfully completing the login procedures and agreeing to the Code of Conduct, you will be able to enter data.</p><p><img src="/core/assets/gtr/images/codescreen.PNG" alt="Registering agreement with the GTR code of conduct" /></p><h2 id="integrity">Maintain the integrity of your Submission Portal account and the data for which you are responsible</h2><p>Sharing of login credentials by multiple individuals is strongly discouraged. Each individual that chooses to submit data to GTR must first read and agree to the Code of Conduct. Individuals that share their login credentials with another person may be compromising the integrity of their submissions. </p><p>The Submission Portal includes a feature that enables multiple individuals from an organization to submit data in a function called <a href="/gtr/docs/manage_permissions/">Groups</a>. Please take advantage of the Groups functions to manage permissions for members of your laboratory to manage data, instead of sharing account information.</p><p><span id="shared-content-1"></span></p>
|
||
</div>
|
||
|
||
|
||
<div>
|
||
<div class="fl_right">
|
||
<div><div><b>OMB NO: 0925-0651</b></div><div><b>EXPIRATION DATE: 01/31/2025</b>*</div><div><a href="/gtr/docs/omb_approval/">Burden Statement</a></div><div style="font-size: 0.9em;">* Renewal in process</div></div>
|
||
</div><div class="title_sec">
|
||
<h1 id="how-to-register-a-laboratory-in-">How to register a laboratory in the GTR</h1>
|
||
</div><p>Instructions on this page assume you have <a href="/gtr/docs/login/">logged into the GTR submission site</a>, and are ready to add information about your laboratory.</p><p>You will start from the home page for your GTR submissions. Click on <strong>Submit a new lab</strong>.</p><p><img src="/core/assets/gtr/images/submit_new_lab.png" alt="Register a new lab in GTR" /></p><p>Complete your data as summarized below. Following submission, the lab will display on the public site within 24-48 hours. GTR staff will reach out to new registrants with a brief questionnaire. Once the lab is approved, you will be able to submit your tests. Be sure to enter <a href="/gtr/docs/submit/#type">tests that are currently in scope</a>.</p><p><strong>The Laboratory Record</strong></p><p>To enter or update information into a laboratory record, you will be presented with a sequence of forms in which to submit data. Each page has a distinct tab.</p><p><img src="/core/assets/gtr/images/tab_progress.png" alt="Progress through tabs" /></p><p>In the table below, tab names in the left column link to the details about how to submit the data for the fields in that section.</p><p><table border="1" cellpadding="1" cellspacing="1">
|
||
<caption>Section (tab)-specific help documents (also in the Lab Submission menu choices)</caption>
|
||
<tbody>
|
||
<tr>
|
||
<td>
|
||
<a href="/gtr/docs/submit/lab_info/">Lab information</a>
|
||
</td>
|
||
<td>Names, contact information, services, and more</td>
|
||
</tr>
|
||
<tr>
|
||
<td>
|
||
<a href="/gtr/docs/submit/lab_personnel/">Personnel</a>
|
||
</td>
|
||
<td>Staff members to be displayed or contacted</td>
|
||
</tr>
|
||
<tr>
|
||
<td>
|
||
<a href="/gtr/docs/submit/lab_license/">Licensure and accreditations</a>
|
||
</td>
|
||
<td>CLIA, State licenses, and more</td>
|
||
</tr>
|
||
<tr>
|
||
<td>
|
||
<a href="/gtr/docs/submit/lab_default/">Default parameters</a>
|
||
</td>
|
||
<td>Default values you want to set to appear on each test you offer</td>
|
||
</tr>
|
||
<tr>
|
||
<td>
|
||
<a href="/gtr/docs/submit/lab_overview">Review & Submit</a>
|
||
</td>
|
||
<td>Review your entry, preview how it will appear on the web site, and submit</td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</p><p><strong>Progressing through the Laboratory Record</strong></p><p>At the bottom of each page is the button <strong>Save & Continue</strong>. If your entries on that page validate, you will be taken to the next tab. </p><p>Your progress through the submission process is marked by the tab color. For a new lab submission, if you have not 'touched' a tab yet, text and tab color remain grey. The tab you are currently processing is shown enlarged. If you have touched a tab (blue text), you can go back to it at any time to update information (<strong>Remember to click on Save & Continue before leaving the page.</strong>). So in the tabs image above, the Lab information has been saved and you are currently on the Personnel data tab.</p><p><strong>Validation errors</strong></p><p>If there is a problem with how you completed the value for a field, you will remain on the same tab. Information will be provided to indicate what content needs to be corrected, and the type of error. In the case below, the name of the city (a required field) was omitted. If at any time you are unsure as to what information to provide in a field you can hover over the help icon (<img src="/core/icons/help.png" alt="help icon" />) to display help information, or review the help page for the tab you are on.</p><p><img src="/core/assets/gtr/images/validation_error.png" alt="How validation errors are represented in the submission interface" /></p><p><span id="shared-content-1"></span></p>
|
||
</div>
|
||
|
||
<div>
|
||
<div class="fl_right">
|
||
<div><div><b>OMB NO: 0925-0651</b></div><div><b>EXPIRATION DATE: 01/31/2025</b>*</div><div><a href="/gtr/docs/omb_approval/">Burden Statement</a></div><div style="font-size: 0.9em;">* Renewal in process</div></div>
|
||
</div><div class="title_sec">
|
||
<h2 id="how-to-register-a-clinical-test-">How to register a clinical test in the GTR</h2>
|
||
</div><p>Instructions on this page assume you have logged into the GTR submission site, have registered your laboratory, and are now ready to submit information about a clinical genetic test.</p><p>On the home page for your GTR submissions, under 'Tests in this lab', click on 'Submit tests'. To submit a test using the submission wizard, go to the section Submit a single test. The default selection is for a clinical genetic test. Click 'Add a new test'. </p><p><img src="/core/assets/gtr/images/SP_submit_single.jpg" alt="Submit a single test" /></p><p>You will be presented with a sequence of pages in which to submit data. Each page has a distinct tab, as seen in the image below. </p><p><img src="/core/assets/gtr/images/test_tabs.png" alt="Tabs indicating the sections in a test submission" /></p><p>At the bottom of each page is the button <strong>Save & Continue</strong>. If your entries on that page validate, you will be taken to the next tab. If there is ever a problem with how you completed a value, you will remain on the same tab. Information will be provided to indicate what content needs to be corrected, and the type of error. If at any time you are unsure as to what information to provide in a field you can hover over the help icon (<img src="/core/icons/help.png" alt="help icon" />) to display help information, or review the help page for the <a href="#tabhelp">tab</a> you are on.</p><p>Your progress through the submission process is marked as follows. If you have not 'touched' a tab yet, text and tab color remain grey. The tab you are currently processing is shown enlarged. If you have touched a tab (blue text), you can go back to it at any time to update information (Remember click on <strong>Save & Continue</strong> before leaving the page.). So in the example above, the submitter is currently on <strong>Ordering</strong>.</p><p>The table below summarizes the content included under each tab. The names in the left column are linked to the details about how to submit the data elements in that section.</p><p><table border="1" cellpadding="1" cellspacing="1">
|
||
<caption>Section (tab)-specific help documents</caption>
|
||
<tbody>
|
||
<tr>
|
||
<td>
|
||
<a href="/gtr/docs/submit/test_basics/">Basics</a>
|
||
</td>
|
||
<td>Type of test, names licenses, etc.</td>
|
||
</tr>
|
||
<tr>
|
||
<td>
|
||
<a href="/gtr/docs/submit/test_order/">Ordering</a>
|
||
</td>
|
||
<td>How to order</td>
|
||
</tr>
|
||
<tr>
|
||
<td>
|
||
<a href="/gtr/docs/submit/test_condition/">Indication</a>
|
||
</td>
|
||
<td>Condition(s) for which the test is appropriate</td>
|
||
</tr>
|
||
<tr>
|
||
<td>
|
||
<a href="/gtr/docs/submit/test_method/">Methodology</a>
|
||
</td>
|
||
<td>Describe the methods used and what is measured (the test targets)</td>
|
||
</tr>
|
||
<tr>
|
||
<td>
|
||
<a href="/gtr/docs/submit/test_interpretation/">Interpretation</a>
|
||
</td>
|
||
<td>Describe how test results are interpreted</td>
|
||
</tr>
|
||
<tr>
|
||
<td>
|
||
<a href="/gtr/docs/submit/test_performance/">Performance</a>
|
||
</td>
|
||
<td>Where the test is performed, clinical validity, clinical utility, and more</td>
|
||
</tr>
|
||
<tr>
|
||
<td>
|
||
<a href="/gtr/docs/submit/test_overview/">Review & Submit</a>
|
||
</td>
|
||
<td>Review your data and submit</td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</p><p><span id="shared-content-1"></span></p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
<!--/.col1-->
|
||
<div class="col2">
|
||
|
||
</div>
|
||
<!--/.col2-->
|
||
<div class="col3">
|
||
|
||
</div>
|
||
<!--/.col3-->
|
||
<div class="col4">
|
||
|
||
</div>
|
||
<!--/.col4-->
|
||
<div class="col5">
|
||
|
||
</div>
|
||
<div class="col6">
|
||
|
||
</div>
|
||
<div class="col7">
|
||
|
||
</div>
|
||
<div class="col8">
|
||
|
||
</div>
|
||
<div class="col9">
|
||
|
||
</div>
|
||
</div><!--/.content-->
|
||
</div><!--/.container-->
|
||
<div id="NCBIFooter_dynamic">
|
||
<!--<component id="NCBIBreadcrumbs"/>
|
||
<component id="NCBIHelpDesk"/>-->
|
||
<noscript><img alt="" src="/stat?jsdisabled=true&ncbi_app=gtr&ncbi_db=&ncbi_pdid=static&ncbi_phid=CE8C0B7B7C7F4D5100000000011200D3" /></noscript>
|
||
</div>
|
||
|
||
|
||
<div xmlns:xi="http://www.w3.org/2001/XInclude">
|
||
<div xmlns="http://www.w3.org/1999/xhtml" class="footer" id="footer" xml:base="http://127.0.0.1/sites/static/header_footer">
|
||
<section class="icon-section">
|
||
<div id="icon-section-header" class="icon-section_header">Follow NCBI</div>
|
||
<div class="grid-container container">
|
||
<div class="icon-section_container">
|
||
<a class="footer-icon" id="footer_twitter" href="https://twitter.com/ncbi" aria-label="Twitter">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="40" height="40" viewBox="0 0 40 40" fill="none">
|
||
<title>Twitter</title>
|
||
<g id="twitterx1008">
|
||
<path id="path1008" d="M6.06736 7L16.8778 20.8991L6.00001 32.2H10.2L18.6 23.1L25.668 32.2H34L22.8 17.5L31.9 7H28.4L20.7 15.4L14.401 7H6.06898H6.06736ZM9.66753 8.73423H12.9327L29.7327 30.4658H26.5697L9.66753 8.73423Z" fill="#5B616B"></path>
|
||
</g>
|
||
</svg>
|
||
</a>
|
||
<a class="footer-icon" id="footer_facebook" href="https://www.facebook.com/ncbi.nlm" aria-label="Facebook"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
|
||
<title>Facebook</title>
|
||
<path class="cls-11" d="M210.5,115.12H171.74V97.82c0-8.14,5.39-10,9.19-10h27.14V52l-39.32-.12c-35.66,0-42.42,26.68-42.42,43.77v19.48H99.09v36.32h27.24v109h45.41v-109h35Z">
|
||
</path>
|
||
</svg></a>
|
||
<a class="footer-icon" id="footer_linkedin" href="https://www.linkedin.com/company/ncbinlm" aria-label="LinkedIn"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
|
||
<title>LinkedIn</title>
|
||
<path class="cls-11" d="M101.64,243.37H57.79v-114h43.85Zm-22-131.54h-.26c-13.25,0-21.82-10.36-21.82-21.76,0-11.65,8.84-21.15,22.33-21.15S101.7,78.72,102,90.38C102,101.77,93.4,111.83,79.63,111.83Zm100.93,52.61A17.54,17.54,0,0,0,163,182v61.39H119.18s.51-105.23,0-114H163v13a54.33,54.33,0,0,1,34.54-12.66c26,0,44.39,18.8,44.39,55.29v58.35H198.1V182A17.54,17.54,0,0,0,180.56,164.44Z">
|
||
</path>
|
||
</svg></a>
|
||
<a class="footer-icon" id="footer_github" href="https://github.com/ncbi" aria-label="GitHub"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
|
||
<defs>
|
||
<style>
|
||
.cls-11,
|
||
.cls-12 {
|
||
fill: #737373;
|
||
}
|
||
|
||
.cls-11 {
|
||
fill-rule: evenodd;
|
||
}
|
||
</style>
|
||
</defs>
|
||
<title>GitHub</title>
|
||
<path class="cls-11" d="M151.36,47.28a105.76,105.76,0,0,0-33.43,206.1c5.28,1,7.22-2.3,7.22-5.09,0-2.52-.09-10.85-.14-19.69-29.42,6.4-35.63-12.48-35.63-12.48-4.81-12.22-11.74-15.47-11.74-15.47-9.59-6.56.73-6.43.73-6.43,10.61.75,16.21,10.9,16.21,10.9,9.43,16.17,24.73,11.49,30.77,8.79,1-6.83,3.69-11.5,6.71-14.14C108.57,197.1,83.88,188,83.88,147.51a40.92,40.92,0,0,1,10.9-28.39c-1.1-2.66-4.72-13.42,1-28,0,0,8.88-2.84,29.09,10.84a100.26,100.26,0,0,1,53,0C198,88.3,206.9,91.14,206.9,91.14c5.76,14.56,2.14,25.32,1,28a40.87,40.87,0,0,1,10.89,28.39c0,40.62-24.74,49.56-48.29,52.18,3.79,3.28,7.17,9.71,7.17,19.58,0,14.15-.12,25.54-.12,29,0,2.82,1.9,6.11,7.26,5.07A105.76,105.76,0,0,0,151.36,47.28Z">
|
||
</path>
|
||
<path class="cls-12" d="M85.66,199.12c-.23.52-1.06.68-1.81.32s-1.2-1.06-.95-1.59,1.06-.69,1.82-.33,1.21,1.07.94,1.6Zm-1.3-1">
|
||
</path>
|
||
<path class="cls-12" d="M90,203.89c-.51.47-1.49.25-2.16-.49a1.61,1.61,0,0,1-.31-2.19c.52-.47,1.47-.25,2.17.49s.82,1.72.3,2.19Zm-1-1.08">
|
||
</path>
|
||
<path class="cls-12" d="M94.12,210c-.65.46-1.71,0-2.37-.91s-.64-2.07,0-2.52,1.7,0,2.36.89.65,2.08,0,2.54Zm0,0"></path>
|
||
<path class="cls-12" d="M99.83,215.87c-.58.64-1.82.47-2.72-.41s-1.18-2.06-.6-2.7,1.83-.46,2.74.41,1.2,2.07.58,2.7Zm0,0">
|
||
</path>
|
||
<path class="cls-12" d="M107.71,219.29c-.26.82-1.45,1.2-2.64.85s-2-1.34-1.74-2.17,1.44-1.23,2.65-.85,2,1.32,1.73,2.17Zm0,0">
|
||
</path>
|
||
<path class="cls-12" d="M116.36,219.92c0,.87-1,1.59-2.24,1.61s-2.29-.68-2.3-1.54,1-1.59,2.26-1.61,2.28.67,2.28,1.54Zm0,0">
|
||
</path>
|
||
<path class="cls-12" d="M124.42,218.55c.15.85-.73,1.72-2,1.95s-2.37-.3-2.52-1.14.73-1.75,2-2,2.37.29,2.53,1.16Zm0,0"></path>
|
||
</svg></a>
|
||
<a class="footer-icon" id="footer_blog" href="https://ncbiinsights.ncbi.nlm.nih.gov/" aria-label="Blog">
|
||
<svg xmlns="http://www.w3.org/2000/svg" id="Layer_1" data-name="Layer 1" viewBox="0 0 40 40">
|
||
<defs><style>.cls-1{fill:#737373;}</style></defs>
|
||
<title>NCBI Insights Blog</title>
|
||
<path class="cls-1" d="M14,30a4,4,0,1,1-4-4,4,4,0,0,1,4,4Zm11,3A19,19,0,0,0,7.05,15a1,1,0,0,0-1,1v3a1,1,0,0,0,.93,1A14,14,0,0,1,20,33.07,1,1,0,0,0,21,34h3a1,1,0,0,0,1-1Zm9,0A28,28,0,0,0,7,6,1,1,0,0,0,6,7v3a1,1,0,0,0,1,1A23,23,0,0,1,29,33a1,1,0,0,0,1,1h3A1,1,0,0,0,34,33Z"></path>
|
||
</svg>
|
||
</a>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
|
||
<section class="container-fluid bg-primary">
|
||
<div class="container pt-5">
|
||
<div class="row mt-3">
|
||
<div class="col-lg-3 col-12">
|
||
<p><a class="text-white" href="https://www.nlm.nih.gov/socialmedia/index.html">Connect with NLM</a></p>
|
||
<ul class="list-inline social_media">
|
||
<li class="list-inline-item"><a href="https://twitter.com/NLM_NIH" aria-label="Twitter" target="_blank" rel="noopener noreferrer">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="35" height="35" viewBox="0 0 36 35" fill="none">
|
||
<title>Twitter</title>
|
||
<g id="twitterx1009" clip-path="url(#clip0_65276_3946)">
|
||
<path id="Vector_Twitter" d="M17.5006 34.6565C26.9761 34.6565 34.6575 26.9751 34.6575 17.4996C34.6575 8.02416 26.9761 0.342773 17.5006 0.342773C8.02514 0.342773 0.34375 8.02416 0.34375 17.4996C0.34375 26.9751 8.02514 34.6565 17.5006 34.6565Z" fill="#205493" stroke="white" stroke-width="1.0" stroke-miterlimit="10"></path>
|
||
<path id="path1009" d="M8.54811 8.5L16.2698 18.4279L8.50001 26.5H11.5L17.5 20L22.5486 26.5H28.5L20.5 16L27 8.5H24.5L19 14.5L14.5007 8.5H8.54927H8.54811ZM11.1197 9.73873H13.4519L25.4519 25.2613H23.1926L11.1197 9.73873Z" fill="white"></path>
|
||
</g>
|
||
<defs>
|
||
<clipPath id="clip0_65276_3946">
|
||
<rect width="35" height="35" fill="white"></rect>
|
||
</clipPath>
|
||
</defs>
|
||
</svg>
|
||
</a></li>
|
||
<li class="list-inline-item"><a href="https://www.facebook.com/nationallibraryofmedicine" aria-label="Facebook" rel="noopener noreferrer" target="_blank">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="35" height="35" viewBox="0 0 36 35" fill="none">
|
||
<title>Facebook</title>
|
||
<g id="Facebook" clip-path="url(#clip0_1717_1086)">
|
||
<path id="Vector_Facebook" d="M15.1147 29.1371C15.1147 29.0822 15.1147 29.0296 15.1147 28.9747V18.9414H11.8183C11.6719 18.9414 11.6719 18.9414 11.6719 18.8018C11.6719 17.5642 11.6719 16.3289 11.6719 15.0937C11.6719 14.9793 11.7062 14.9518 11.816 14.9518C12.8683 14.9518 13.9206 14.9518 14.9751 14.9518H15.1215V14.8329C15.1215 13.8057 15.1215 12.774 15.1215 11.7492C15.1274 10.9262 15.3148 10.1146 15.6706 9.37241C16.1301 8.38271 16.9475 7.60378 17.9582 7.19235C18.6492 6.90525 19.3923 6.76428 20.1405 6.7783C21.0029 6.79202 21.8653 6.83091 22.7278 6.86065C22.8879 6.86065 23.048 6.89496 23.2082 6.90182C23.2974 6.90182 23.3271 6.94071 23.3271 7.02993C23.3271 7.54235 23.3271 8.05477 23.3271 8.5649C23.3271 9.16882 23.3271 9.77274 23.3271 10.3767C23.3271 10.4819 23.2974 10.5139 23.1921 10.5116C22.5379 10.5116 21.8814 10.5116 21.2271 10.5116C20.9287 10.5184 20.6316 10.5528 20.3395 10.6146C20.0822 10.6619 19.8463 10.7891 19.6653 10.9779C19.4842 11.1668 19.3672 11.4078 19.3307 11.6669C19.2857 11.893 19.2612 12.1226 19.2575 12.3531C19.2575 13.1904 19.2575 14.0299 19.2575 14.8695C19.2575 14.8946 19.2575 14.9198 19.2575 14.9564H23.0229C23.1807 14.9564 23.183 14.9564 23.1624 15.1074C23.0778 15.7662 22.9885 16.425 22.9039 17.0816C22.8322 17.6321 22.7636 18.1827 22.698 18.7332C22.6729 18.9437 22.6797 18.9437 22.4693 18.9437H19.2644V28.8992C19.2644 28.9793 19.2644 29.0593 19.2644 29.1394L15.1147 29.1371Z" fill="white"></path>
|
||
<path id="Vector_2_Facebook" d="M17.5006 34.657C26.9761 34.657 34.6575 26.9756 34.6575 17.5001C34.6575 8.02465 26.9761 0.343262 17.5006 0.343262C8.02514 0.343262 0.34375 8.02465 0.34375 17.5001C0.34375 26.9756 8.02514 34.657 17.5006 34.657Z" stroke="white" stroke-width="1.0" stroke-miterlimit="10"></path>
|
||
</g>
|
||
<defs>
|
||
<clipPath id="clip0_1717_1086">
|
||
<rect width="35" height="35" fill="white"></rect>
|
||
</clipPath>
|
||
</defs>
|
||
</svg>
|
||
</a></li>
|
||
<li class="list-inline-item"><a href="https://www.youtube.com/user/NLMNIH" aria-label="Youtube" target="_blank" rel="noopener noreferrer">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="35" height="35" viewBox="0 0 36 35" fill="none">
|
||
<title>Youtube</title>
|
||
<g id="YouTube" clip-path="url(#clip0_1717_1101)">
|
||
<path id="Vector_Youtube" d="M26.2571 11.4791C25.9025 11.1589 25.5709 10.9576 24.228 10.834C22.5512 10.6785 20.2797 10.6556 18.564 10.6533H16.4365C14.7208 10.6533 12.4493 10.6785 10.7725 10.834C9.43196 10.9576 9.09798 11.1589 8.7434 11.4791C7.81464 12.321 7.6202 14.6268 7.59961 16.8938C7.59961 17.3178 7.59961 17.741 7.59961 18.1635C7.62706 20.4121 7.82837 22.686 8.7434 23.521C9.09798 23.8412 9.42967 24.0425 10.7725 24.1661C12.4493 24.3216 14.7208 24.3445 16.4365 24.3468H18.564C20.2797 24.3468 22.5512 24.3216 24.228 24.1661C25.5686 24.0425 25.9025 23.8412 26.2571 23.521C27.1722 22.6929 27.3735 20.451 27.4009 18.2206C27.4009 17.7402 27.4009 17.2599 27.4009 16.7795C27.3735 14.5491 27.1699 12.3072 26.2571 11.4791ZM15.5604 20.5311V14.652L20.561 17.5001L15.5604 20.5311Z" fill="white"></path>
|
||
<path id="Vector_2_Youtube" d="M17.5006 34.657C26.9761 34.657 34.6575 26.9756 34.6575 17.5001C34.6575 8.02465 26.9761 0.343262 17.5006 0.343262C8.02514 0.343262 0.34375 8.02465 0.34375 17.5001C0.34375 26.9756 8.02514 34.657 17.5006 34.657Z" stroke="white" stroke-width="1.0" stroke-miterlimit="10"></path>
|
||
</g>
|
||
<defs>
|
||
<clipPath id="clip0_1717_1101">
|
||
<rect width="35" height="35" fill="white"></rect>
|
||
</clipPath>
|
||
</defs>
|
||
</svg>
|
||
</a></li>
|
||
</ul>
|
||
</div>
|
||
<div class="col-lg-3 col-12">
|
||
<p class="address_footer text-white">National Library of Medicine<br />
|
||
<a href="https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/@38.9959508,-77.101021,17z/data=!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb:0x19156f88b27635b8!8m2!3d38.9959508!4d-77.0988323" class="text-white" target="_blank" rel="noopener noreferrer">8600 Rockville Pike<br />
|
||
Bethesda, MD 20894</a></p>
|
||
</div>
|
||
<div class="col-lg-3 col-12 centered-lg">
|
||
<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
|
||
<a href="https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office" class="text-white">FOIA</a><br />
|
||
<a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" class="text-white" id="vdp">HHS Vulnerability Disclosure</a></p>
|
||
</div>
|
||
<div class="col-lg-3 col-12 centered-lg">
|
||
<p><a class="supportLink text-white" href="https://support.nlm.nih.gov/">Help</a><br />
|
||
<a href="https://www.nlm.nih.gov/accessibility.html" class="text-white">Accessibility</a><br />
|
||
<a href="https://www.nlm.nih.gov/careers/careers.html" class="text-white">Careers</a></p>
|
||
</div>
|
||
</div>
|
||
<div class="row">
|
||
<div class="col-lg-12 centered-lg">
|
||
<nav class="bottom-links">
|
||
<ul class="mt-3">
|
||
<li>
|
||
<a class="text-white" href="//www.nlm.nih.gov/">NLM</a>
|
||
</li>
|
||
<li>
|
||
<a class="text-white" href="https://www.nih.gov/">NIH</a>
|
||
</li>
|
||
<li>
|
||
<a class="text-white" href="https://www.hhs.gov/">HHS</a>
|
||
</li>
|
||
<li>
|
||
<a class="text-white" href="https://www.usa.gov/">USA.gov</a>
|
||
</li>
|
||
</ul>
|
||
</nav>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
<script type="text/javascript" src="/portal/portal3rc.fcgi/rlib/js/InstrumentOmnitureBaseJS/InstrumentNCBIConfigJS/InstrumentNCBIBaseJS/InstrumentPageStarterJS.js?v=1"> </script>
|
||
<script type="text/javascript" src="/portal/portal3rc.fcgi/static/js/hfjs2.js"> </script>
|
||
</div>
|
||
</div>
|
||
<!--/.footer-->
|
||
<p class="last-updated small">Last updated: 2018-04-06T20:42:15Z</p>
|
||
</div>
|
||
<!--/.page-->
|
||
</div>
|
||
<!--/.wrap-->
|
||
<span class="PAFAppResources"></span>
|
||
|
||
|
||
</div><!-- /.twelve_col -->
|
||
</div>
|
||
<!-- /.grid -->
|
||
|
||
|
||
|
||
<!-- usually for JS scripts at page bottom -->
|
||
<span class="pagefixtures"></span>
|
||
|
||
|
||
<!-- CE8B5AF87C7FFCB1_0191SID /projects/GTR/gtr1/gtr1@1.224 portal105 v4.1.r689238 Tue, Oct 22 2024 16:10:51 -->
|
||
<span id="portal-csrf-token" style="display:none" data-token="CE8B5AF87C7FFCB1_0191SID"></span>
|
||
|
||
<script type="text/javascript" src="//static.pubmed.gov/portal/portal3rc.fcgi/4221774/js/3879255/4121861/4052736/4171016/3898962/3538227/4209230.js" snapshot="gtr"></script></body>
|
||
</html>
|
||
|