360 lines
18 KiB
HTML
360 lines
18 KiB
HTML
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<meta http-equiv="Content-Type" content="text/html; charset=iso-8859-1">
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<title>GeneMap'99</title>
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<meta name="description" content="Electronic access to a gene-based STS map of
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the human genome developed by the International Radiation Hybrid
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Mapping Consortium">
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<meta name="keywords" content="Gene Map, Transcript Map, STS Map, Sequence Tagged Site,
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Genes and Disease, RH, Radiation Hybrid, GeneBridge 4, Stanford G3">
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<link rel="stylesheet" href="NCBI.css">
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</head>
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<body bgcolor="#FFFFFF" text="#000000" link="#0066CC" vlink="#003399" alink="#009900" background="IMG/bkgd2.gif">
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<!-- #BeginLibraryItem "/Library/Banner3.lbi" --><table border="0" width="600" cellspacing="0" cellpadding="0">
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<td width="140">
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<img src="IMG/ncbilogo.gif" width="130" height="45"><br>
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<td colspan="2">
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<table border="0" width="600" cellspacing="0" cellpadding="1">
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<tr bgcolor="#000000">
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<td class="BAR" width="85"><a href="http://www.genethon.fr/" class="BAR">Généthon</a></td>
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<td class="BAR" width="85"><a href="http://www.sanger.ac.uk/" class="BAR">Sanger</a></td>
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<td class="BAR" width="85"><a href="http://www-shgc.stanford.edu/" class="BAR">SHGC</a></td>
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<td class="BAR" width="85"><a href="http://www.genome.wi.mit.edu/" class="BAR">WICGR</a></td>
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<td class="BAR" width="85"><a href="http://www.well.ox.ac.uk/" class="BAR">WTCHG</a></td>
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<td class="BAR" width="85"><a href="http://www.ebi.ac.uk/" class="BAR">EBI</a></td>
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<td class="BAR" width="90"><a href="http://www.ncbi.nlm.nih.gov/" class="BAR">NCBI</a></td>
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</tr>
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</table>
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</td>
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<tr bgcolor="#CCCCFF">
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<td width="140" class="table-text">
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<div align="right">Chromosomes: </div>
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</td>
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<td width="460">
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<table border="0" width="460" class="table-text" cellspacing="0" cellpadding="1">
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<tr>
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<td width="20"><a href="/mapview/maps.cgi?TAXID=9606&MAP0=ideogr,g3,gb4&LINKS=ON&VERBOSE=ON&CHR=1">1</a></td>
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<td width="20"><a href="/mapview/maps.cgi?TAXID=9606&MAP0=ideogr,g3,gb4&LINKS=ON&VERBOSE=ON&CHR=2">2</a></td>
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<td width="20"><a href="/mapview/maps.cgi?TAXID=9606&MAP0=ideogr,g3,gb4&LINKS=ON&VERBOSE=ON&CHR=3">3</a></td>
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<td width="20"><a href="/mapview/maps.cgi?TAXID=9606&MAP0=ideogr,g3,gb4&LINKS=ON&VERBOSE=ON&CHR=4">4</a></td>
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<td width="20"><a href="/mapview/maps.cgi?TAXID=9606&MAP0=ideogr,g3,gb4&LINKS=ON&VERBOSE=ON&CHR=5">5</a></td>
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<td width="20"><a href="/mapview/maps.cgi?TAXID=9606&MAP0=ideogr,g3,gb4&LINKS=ON&VERBOSE=ON&CHR=6">6</a></td>
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<td width="20"><a href="/mapview/maps.cgi?TAXID=9606&MAP0=ideogr,g3,gb4&LINKS=ON&VERBOSE=ON&CHR=7">7</a></td>
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<td width="20"><a href="/mapview/maps.cgi?TAXID=9606&MAP0=ideogr,g3,gb4&LINKS=ON&VERBOSE=ON&CHR=8">8</a></td>
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<td width="20"><a href="/mapview/maps.cgi?TAXID=9606&MAP0=ideogr,g3,gb4&LINKS=ON&VERBOSE=ON&CHR=9">9</a></td>
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<td width="20"><a href="/mapview/maps.cgi?TAXID=9606&MAP0=ideogr,g3,gb4&LINKS=ON&VERBOSE=ON&CHR=10">10</a></td>
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<td width="20"><a href="/mapview/maps.cgi?TAXID=9606&MAP0=ideogr,g3,gb4&LINKS=ON&VERBOSE=ON&CHR=11">11</a></td>
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<td width="20"><a href="/mapview/maps.cgi?TAXID=9606&MAP0=ideogr,g3,gb4&LINKS=ON&VERBOSE=ON&CHR=12">12</a></td>
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<td width="20"><a href="/mapview/maps.cgi?TAXID=9606&MAP0=ideogr,g3,gb4&LINKS=ON&VERBOSE=ON&CHR=13">13</a></td>
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<td width="20"><a href="/mapview/maps.cgi?TAXID=9606&MAP0=ideogr,g3,gb4&LINKS=ON&VERBOSE=ON&CHR=14">14</a></td>
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<td width="20"><a href="/mapview/maps.cgi?TAXID=9606&MAP0=ideogr,g3,gb4&LINKS=ON&VERBOSE=ON&CHR=15">15</a></td>
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<td width="20"><a href="/mapview/maps.cgi?TAXID=9606&MAP0=ideogr,g3,gb4&LINKS=ON&VERBOSE=ON&CHR=16">16</a></td>
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<td width="20"><a href="/mapview/maps.cgi?TAXID=9606&MAP0=ideogr,g3,gb4&LINKS=ON&VERBOSE=ON&CHR=17">17</a></td>
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<td width="20"><a href="/mapview/maps.cgi?TAXID=9606&MAP0=ideogr,g3,gb4&LINKS=ON&VERBOSE=ON&CHR=18">18</a></td>
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<td width="20"><a href="/mapview/maps.cgi?TAXID=9606&MAP0=ideogr,g3,gb4&LINKS=ON&VERBOSE=ON&CHR=19">19</a></td>
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<td width="20"><a href="/mapview/maps.cgi?TAXID=9606&MAP0=ideogr,g3,gb4&LINKS=ON&VERBOSE=ON&CHR=20">20</a></td>
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<td width="20"><a href="/mapview/maps.cgi?TAXID=9606&MAP0=ideogr,g3,gb4&LINKS=ON&VERBOSE=ON&CHR=21">21</a></td>
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<td width="20"><a href="/mapview/maps.cgi?TAXID=9606&MAP0=ideogr,g3,gb4&LINKS=ON&VERBOSE=ON&CHR=22">22</a></td>
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<td width="20"><a href="/mapview/maps.cgi?TAXID=9606&MAP0=ideogr,g3,gb4&LINKS=ON&VERBOSE=ON&CHR=X">X</a></td>
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</table>
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<div align="right">Search for: </div>
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<input type="TEXT" name="EXPR" size="25">
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<table border="0" cellspacing="0" cellpadding="0" width="600">
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<tr valign="TOP">
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<td width="128"> <img src="IMG/pix_tr.gif" width="128" height="1"><br><br>
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<table border="0" width="128" cellspacing="0" cellpadding="0">
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<tr valign="bottom">
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<td width="8" class="sidebar-small"> </td>
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<td width="112" class="sidebar-small"><a href="/genome/guide/human/"><font color="#CCCCFF">Human
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Genome Resources</font></a><br>
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<img src="IMG/pix_tr.gif" width="1" height="4"></td>
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<td width="8" align="right"><img src="IMG/GoUp1.gif" width="8" height="19"></td>
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</tr>
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<tr align="right">
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<td colspan="3"><img src="IMG/GoUp2.gif" width="128" height="12"></td>
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</table>
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<br>
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<!-- @SITEMAP WIDTH=128 FILE="gm98.sm" SELECTED=0-->
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<p> </p><p> </p><p> <br>
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<br>
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<br>
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</p></td>
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<td width="16"><img src="IMG/pix_tr.gif" width="16" height="1"></td>
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<td width="456">
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<p> </p>
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<p class="HEAD1">A New Gene Map of the Human Genome</p>
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<p class="HEAD2"><font color="#000000">The International RH Mapping Consortium</font><br>
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</p>
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<table border="0" width="456" cellspacing="0" cellpadding="0">
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<tr valign="top">
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<td width="310">
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<table border="0" width="310" cellspacing="0" cellpadding="1" bgcolor="#CCCCFF">
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<tr>
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<td class="HEAD3"><img src="IMG/pix_tr.gif" width="1" height="2"><br>
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The Book of Life<br>
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<img src="IMG/pix_tr.gif" width="1" height="2"></td>
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</tr>
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</table>
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<p><font size="+1">T</font>he Human Genome Project is entering its climactic phase that will result, as early as 2003, in
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a complete and accurate DNA sequence representing the genetic blueprint and evolutionary history of the human species. Moreover,
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a "working draft" of this "book of life" may be available as early as 2001 and, in both cases, an index to the chapters
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and paragraphs will greatly enhance both the completion of the finished product as well as the practical utility of the
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intermediate results for biomedicine. </p>
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<p>This new gene map represents such an index as it includes the locations, within this text, of more than 30,000 genes and
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provides an early glimpse of some of the most important pieces of the genome. Even more importantly, the map can be immediately
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applied by scientists to the identification and isolation of genes that either directly cause human ailments or increase
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our susceptibility to disease. </p>
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<table border="0" width="310" cellspacing="0" cellpadding="1" bgcolor="#CCCCFF">
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<tr>
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<td class="HEAD3">Gene Mapping Progress</td>
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</tr>
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</table>
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<p><font size="+1"><img src="IMG/graph-tiny.gif" width="128" height="88" border="0" vspace="1" hspace="1" align="right">
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T</font>he accompanying graph shows the tremendous progress that has been made in the mapping of human genes and this
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new map represents a major milestone in the Human Genome Project. Apart from its utility in advancing our understanding
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of the genetic basis of disease, it also provides a framework and focus for accelerated sequencing efforts by highlighting
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key landmarks (gene-rich regions) of the chromosomes. The construction of this new map was only made possible through the
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cooperative efforts of an international consortium of scientists who provide equal, full and unrestricted access to the
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data for the advancement of biology and human health. </p>
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<table border="0" width="310" cellspacing="0" cellpadding="1" bgcolor="#CCCCFF">
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<tr>
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<td class="HEAD3">References</td>
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</tr>
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</table>
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<br>
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<table border="0" width="310" cellspacing="0" cellpadding="0">
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<tr valign="top">
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<td width="18"><a href="http://www.ncbi.nlm.nih.gov/pubmed/7670491"><img src="IMG/doc.gif" width="15" height="18" border="0"></a></td>
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<td width="292" class="table-text">Berry, R., et al. ,
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Gene-based sequence-tagged-sites (STSs) as the basis for a human
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gene map. Nat. Genet. 10, 415-423
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(1995). <br>
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</td>
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</tr>
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<tr valign="top">
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<td width="18"><a href="http://www.ncbi.nlm.nih.gov/pubmed/7670480"><img src="IMG/doc.gif" width="15" height="18" border="0"></a></td>
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<td width="292" class="table-text">Boguski, M.S. and Schuler,
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G.D. ESTablishing a human transcript map. Nat. Genet. 10, 369-371
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(1995). <br>
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</td>
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</tr>
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<tr valign="top">
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<td width="18"><a href="http://www.ncbi.nlm.nih.gov/pubmed/9784132"><img src="IMG/doc.gif" width="15" height="18" border="0"></a></td>
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<td width="292" class="table-text">Deloukas, P., et al. A physical
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map of 30,000 human genes. Science 282, 744-746 (1998). <br>
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</td>
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</tr>
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<tr valign="top">
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<td width="18"><a href="http://www.ncbi.nlm.nih.gov/pubmed/8852657"><img src="IMG/doc.gif" width="15" height="18" border="0"></a></td>
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<td width="292" class="table-text">Gyapay, G., et al. A radiation
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hybrid map of the human genome. Hum. Mol. Genet. 5, 339-346
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(1996). <br>
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</td>
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</tr>
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<tr valign="top">
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<td width="18"><a href="http://www.ncbi.nlm.nih.gov/pubmed/8533086"><img src="IMG/doc.gif" width="15" height="18" border="0"></a></td>
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<td width="292" class="table-text"> Hudson, T., et al. An STS-based
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map of the human genome. Science 270, 1945-1954 (1995).<br>
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</td>
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</tr>
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<tr valign="top">
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<td width="18"><a href="http://www.ncbi.nlm.nih.gov/pubmed/8849440"><img src="IMG/doc.gif" width="15" height="18" border="0"></a></td>
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<td width="292" class="table-text">Schuler, G.D., et al. A gene
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map of the human genome. Science 274, 540-546 (1996). <br>
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</td>
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</tr>
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<tr valign="top">
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<td width="18"><a
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href="http://www.ncbi.nlm.nih.gov/pubmed/9149939"><img src="IMG/doc.gif" width="15" height="18" border="0"></a></td>
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<td width="292" class="table-text">Stewart, E., et al. An STS-based
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radiation hybrid map of the human genome. Genome Res. 7, 422-433
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(1997). <br>
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</td>
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</tr>
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<tr valign="top">
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<td width="18"><a
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href="http://www.ncbi.nlm.nih.gov/pubmed/2030965"><img src="IMG/doc.gif" width="15" height="18" border="0"></a></td>
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<td width="292" class="table-text">Wilcox, A.S., et al. Use of 3' untranslated sequences of human cDNAs for rapid
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chromosome assignment and conversion to STSs: implications for an
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expression map of the genome. Nucl Acids Res 25, 1837-1843 (1991). <br>
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</td>
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</tr>
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</table>
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<p> </p>
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</td>
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<td width="14"><img src="IMG/pix_tr.gif" width="14" height="1"></td>
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<td width="132">
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<table border="0" width="100%" bgcolor="#CCCC99" cellspacing="0" cellpadding="1">
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<tr>
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<td>
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<table border="0" width="100%" cellspacing="0" cellpadding="6" bgcolor="#FFFFCC">
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<tr>
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<td valign="top">
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<p class="LB-link" align="left"><b>This web site</b> is the electronic data supplement for the Gene Map paper
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</p>
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<center>
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<table border="0" cellspacing="0" cellpadding="1" bgcolor="#000000">
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<tr>
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<td><a href="http://www.ncbi.nlm.nih.gov/pubmed/9784132"><img src="IMG/ScienceCover.gif" width="75" height="101" border="0"></a></td>
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</tr>
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</table>
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<br>
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</center>
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<p class="LB-link" align="left">See: <a href="http://www.ncbi.nlm.nih.gov/pubmed/9784132">Deloukas,
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P., et al., Science 282, 744-746, 1998</a>.<br>
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</p>
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</td>
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</tr>
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</table>
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</td>
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</tr>
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</table>
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<br>
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<table border="0" width="132" cellspacing="0" cellpadding="0">
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<tr valign="top">
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<td colspan="2" class="LB-title" nowrap> <img src="IMG/LinkSet1.gif" width="132" height="10"></td>
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</tr>
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<tr valign="top">
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<td width="12"><img src="IMG/LinkSet2.gif" width="12" height="21"></td>
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<td width="120" class="LB-title">Also of interest</td>
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</tr>
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<tr valign="top">
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<td width="12"> </td>
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<td width="120" class="LB-link"> <a href="http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&rid=gnd.preface.91">Genes and Disease<br>
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</a> <a href="http://www.ncbi.nlm.nih.gov/SCIENCE96/">GeneMap'96</a> </td>
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</tr>
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</table>
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<br>
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<td width="12"><img src="IMG/LinkSet2.gif" width="12" height="21"></td>
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<td width="120" class="LB-title" nowrap>Genome Project</td>
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</tr>
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<td width="12"> </td>
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<td width="120" class="LB-link" nowrap> <a href="http://www.nhgri.nih.gov/HGP/">About the HGP</a><br>
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<a href="http://www.nhgri.nih.gov/NEWS/Finish_sequencing_early/Intent_to_finish_sequencing_early.html">New HGP Goals</a><br>
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<a href="http://www.nhgri.nih.gov/NEWS/Finish_sequencing_early/twenty_questions_about_DNA.html">DNA 20 Questions</a><br>
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</td>
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</tr>
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</table>
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<br>
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<table border="0" width="132" cellspacing="0" cellpadding="0">
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<tr valign="baseline">
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<td colspan="2"><img src="IMG/LinkSet1.gif" width="132" height="10"></td>
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<tr valign="top">
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<td width="12"><img src="IMG/LinkSet2.gif" width="12" height="21"></td>
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<td width="120" class="LB-title">RH Servers</td>
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</tr>
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<tr valign="top">
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<td width="12"> </td>
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<td width="120" class="LB-link"> <a href="http://www.sanger.ac.uk/RHserver/RHserver.shtml">Sanger GB4 Server</a><br>
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<a href="http://www-shgc.stanford.edu/RH/G3index.html">Stanford G3 Server</a><br>
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</td>
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</tr>
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</table>
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<br>
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-->
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<table border="0" width="132" cellspacing="0" cellpadding="0">
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<td colspan="2" class="LB-title"><img src="IMG/LinkSet1.gif" width="132" height="10"></td>
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<td width="12"><img src="IMG/LinkSet2.gif" width="12" height="21"></td>
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<td width="120" class="LB-title">Other Databases</td>
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</tr>
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<tr valign="top">
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<td width="12"> </td>
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<td width="120" class="LB-link">
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<a href="http://www.ncbi.nlm.nih.gov/Omim/">OMIM</a><br>
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<a href="http://www.ncbi.nlm.nih.gov/UniGene/">UniGene</a> <br>
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<a href="http://www.ncbi.nlm.nih.gov/PubMed/">PubMed</a> </td>
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</tr>
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</table>
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<p> </p>
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</td>
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</tr>
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</table>
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<tr valign="TOP">
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<td width="128"> </td>
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<td width="16"> </td>
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<td width="456">
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<p> </p>
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<p align="center"><b>Questions or Comments?<br>
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Write to the <a href="mailto:info@ncbi.nlm.nih.gov?subject=GeneMap'98">NCBI
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Service Desk</a></b><br>
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</p>
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</td>
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</tr>
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</table>
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<p> </p>
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