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503 KiB
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<h1 class="res_name"><a href="/gene/">Gene</a></h1>
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<h2 class="res_tagline">Genes and mapped phenotypes</h2>
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<div class="search"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="pubmed">PubMed</option><option value="clinvar">ClinVar</option><option value="medgen">MedGen</option><option value="books" class="last">Books</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly" data-ac_dict="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene" selected="selected" data-ac_dict="gene">Gene</option><option value="genome" data-ac_dict="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen">MedGen</option><option value="mesh">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore" data-ac_dict="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein" data-ac_dict="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search Gene. Use up and down arrows to choose an item from the autocomplete." value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="dictionary:'gene',disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'yes',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div><ul class="searchlinks inline_list"><set></set><li><a href="/gene/advanced">Advanced</a></li><li class="help"><a id="help" class="jig-ncbihelpwindow" target="ncbihelp" name="help" href="/books/NBK3841/">Help</a></li></ul></div>
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<h2 class="offscreen_noflow">Result Filters</h2>
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<div class="facet_cont" data-db="gene" data-default_grps="fg_gene-sources,fg_categories,fg_sequence-content,fg_status" data-sd="db:'gene',op:'select',term:'',qk:'2817',linkname:'',idsfromresult:'920',extra:''"><ul class="facet" data-filter_id="gene-sources" id="_gene-sources"><li class="filter_grp "><div class="clearfix"><h3>Gene sources</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="genomic">Genomic</a></li></ul></li></ul><ul class="facet" data-filter_id="categories" id="_categories"><li class="filter_grp "><div class="clearfix"><h3>Categories</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="alt-splicing">Alternatively spliced</a></li><li class="fil_val"><a href="#" data-value_id="annotated-genes">Annotated genes</a></li><li class="fil_val"><a href="#" data-value_id="gene-type-protein-coding">Protein-coding</a></li></ul></li></ul><ul class="facet" data-filter_id="sequence-content" id="_sequence-content"><li class="filter_grp "><div class="clearfix"><h3>Sequence content</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="seq-ccds">CCDS</a></li><li class="fil_val"><a href="#" data-value_id="seq-ensembl">Ensembl</a></li><li class="fil_val"><a href="#" data-value_id="refseq">RefSeq</a></li><li class="fil_val"><a href="#" data-value_id="seq-refseqgene">RefSeqGene</a></li></ul></li></ul><ul class="facet" data-filter_id="status" id="_status"><li class="filter_grp "><div class="clearfix"><h3>Status</h3><a href="#" data-value_id="" class="clear clear_show">Clear</a></div><ul><li class="fil_val selected"><a href="#" data-value_id="current-only">Current</a><span class="fcount">(1)</span></li></ul></li></ul><div id="chr-location-facet-wrapper" data-bid="MCID_67c9d8e669195c35ad6bd918" data-hid="MCID_67c90f2d64f30b25346ccae2" data-qky="2817" class="disabled" style="display:none"><ul class="facet" data-filter_id="chromosomal-region" id="_chromosomal-region" data-of="yes"><li class="filter_grp of_grp"><div class="clearfix"><h3>Chromosome locations</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><a id="facet_ofchromosomal-region" href="#facet_of_divchromosomal-region" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'middle left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '375px'" data-value_id="fetch_more">more...</a><div id="facet_of_divchromosomal-region" style="display:none;" class="of_popup"><h4>Chromosome locations</h4><label for="organism-filter" style="width:100%;margin-bottom:.2em;" class="">Select an organism by typing or scrolling</label><input type="text" placeholder="Enter text to narrow down the list" id="organism-filter" style="width:98%;" autocomplete="off" /><br /><div id="chr-region-tax-list"><select id="of_chromosomal-region" size="9" class="chr-region-tax-list" style="width:100%;"></select></div><div id="chr-location-info-ctrl" data-disabled="disabled"><div class="chr-field"><label for="chr-name">Chromosome</label><br /><select id="chr-name" class="chr-field" disabled="disabled"></select></div><div class="chr-field"><label for="chr-from">From</label><br /><input type="text" name="chr-from" id="chr-from" disabled="disabled" class="chr-field" /></div><div class="chr-field"><label for="chr-to">To</label><br /><input type="text" name="chr-to" id="chr-to" disabled="disabled" class="chr-field" /></div></div><div class="actions clearfix"><button class="jig-ncbibutton of_add apply-chr" data-jigconfig="'color': 'ui-ncbibutton-blue'">Apply</button></div></div></ul></li></ul></div><ul class="facet facet_reset"><li><a href="#" data-value_id="reset">Clear all</a></li></ul><ul class="facet_tools"><li><a id="more_filter_groups_link" href="#more_filter_groups" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'top left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '180px'">
|
||
Show additional filters</a></li><div id="more_filter_groups" style="display:none;" class="facets_dialog"><button class="ui-ncbipopper-close-button ui-ncbipopper-close-button-generated ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-blue" generated="true" role="button" aria-disabled="false"><span class="ui-button-text">x</span></button><h4>Additional filters</h4><ul class="filter_groups_more facet"><li><input type="checkbox" id="fg_gene-sources" /><label for="fg_gene-sources">Gene sources</label></li><li><input type="checkbox" id="fg_categories" /><label for="fg_categories">Categories</label></li><li><input type="checkbox" id="fg_sequence-content" /><label for="fg_sequence-content">Sequence content</label></li><li><input type="checkbox" id="fg_status" /><label for="fg_status">Status</label></li><li><input type="checkbox" id="fg_chromosomal-region" /><label for="fg_chromosomal-region">Chromosome locations</label></li><li><input id="fg_field_search" type="checkbox" /><label for="fg_field_search">Search fields</label></li></ul><div class="actions clearfix"><button class="filter_groups_more_apply jig-ncbibutton primary-action" id="filter_groups_apply" data-jigconfig="'color': 'ui-ncbibutton-blue'">Show</button></div></div></ul><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetsUrlFrag" sid="1" type="hidden" value="filters=current-only" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetSubmitted" sid="1" type="hidden" value="false" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.BMFacets" sid="1" type="hidden" value="" /></div>
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<span style="display: block; text-align: center;">S</span>
|
||
<span style="display: block; text-align: center;">I</span>
|
||
<span style="display: block; text-align: center;">D</span>
|
||
<span style="display: block; text-align: center;">E</span>
|
||
<span style="display: block; text-align: center;">B</span>
|
||
<span style="display: block; text-align: center;">A</span>
|
||
<span style="display: block; text-align: center;">R</span>
|
||
</div>
|
||
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|
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|
||
<div class="results_settings one_setting"><ul class="inline_list left display_settings"><li><a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Display" sid="0" href="#" class="jig-ncbipopper" data-jigconfig="triggerPosition : 'bottom center',destPosition : 'top center',destSelector : '#display_settings_menu_report', hasArrow : false,openEvent : 'click',closeEvent : 'click',isTriggerElementCloseClick: false,addCloseButton : false, groupName: 'entrez_pg'" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Display">Full Report<span href="#" class="tgt_dark"></span></a></li></ul><div id="display_settings_menu_report" class="disp_settings tabPopper"><fieldset class="format"><legend>Format</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="1" value="full_report" format="" id="full_report" checked="true" /><label for="full_report">Full Report</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="2" value="full_report" format="text" id="full_reporttext" /><label for="full_reporttext">Full Report (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="3" value="expression" format="" id="expression" /><label for="expression">Expression</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="4" value="gene_table" format="" id="gene_table" /><label for="gene_table">Gene Table</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="5" value="gene_table" format="text" id="gene_tabletext" /><label for="gene_tabletext">Gene Table (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="6" value="generif" format="" id="generif" /><label for="generif">GeneRIF</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="7" value="docsum" format="" id="docsum" /><label for="docsum">Summary</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="8" value="docsum" format="text" id="docsumtext" /><label for="docsumtext">Summary (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="9" value="tabular" format="" id="tabular" /><label for="tabular">Tabular</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="10" value="tabular" format="text" id="tabulartext" /><label for="tabulartext">Tabular (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="11" value="asn1" format="text" id="asn1text" /><label for="asn1text">ASN.1</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="12" value="xml" format="text" id="xmltext" /><label for="xmltext">XML</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="13" value="uilist" format="text" id="uilisttext" /><label for="uilisttext">UI List</label></li></ul></fieldset></div><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SetDisplay" sid="1" class="button_apply ncbipopper-close-button" style="display:none">Apply</button><h4 class="content_header send_to align_right jig-ncbipopper" id="sendto" data-jigconfig="triggerPosition:'bottom center', destPosition : 'top center',destSelector : '#send_to_menu', hasArrow : false, openEvent : 'click',closeEvent : 'click', isTriggerElementCloseClick: false, addCloseButton:true, groupName: 'entrez_pg', adjustFit:'none'"><a href="#" sourceContent="send_to_menu" class="tgt_dark">Send to:</a><script type="text/javascript">
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</script></h4><div id="send_to_menu" class="tabPopper send_to"><fieldset><legend>Choose Destination</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendTo" sid="1" value="File" id="dest_File" /><label for="dest_File">File</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendTo" sid="2" value="AddToClipboard" id="dest_AddToClipboard" /><label for="dest_AddToClipboard">Clipboard</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendTo" sid="3" value="AddToCollections" id="dest_AddToCollections" /><label for="dest_AddToCollections">Collections</label></li></ul></fieldset><div class="submenu file" id="submenu_File" style="display: none;"><p id="submenu_File_hint" class="hidden"></p><ul><li><label for="file_format">Format</label><select id="file_format" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.FFormat" sid="1"><option value="full_report" format="text" selected="selected">Full Report (text)</option><option value="gene_table" format="text">Gene Table (text)</option><option value="docsum" format="text">Summary (text)</option><option value="tabular" format="text">Tabular (text)</option><option value="asn1" format="text">ASN.1</option><option value="xml" format="text">XML</option><option value="uilist" format="text">UI List</option></select></li></ul><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendToSubmit" sid="1" class="button_apply file ncbipopper-close-button" type="submit" cmd="File">Create File</button></div><div class="submenu addtoclipboard" id="submenu_AddToClipboard" style="display: none;"><p id="submenu_AddToClipboard_hint" class="hidden"></p><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendToSubmit" sid="2" class="button_apply clipboard ncbipopper-close-button" type="submit" cmd="AddToClipboard">Add to Clipboard</button></div><div class="submenu addtocollections" id="submenu_AddToCollections" style="display: none;"><p id="submenu_AddToCollections_hint" class="hidden"></p><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendToSubmit" sid="3" class="button_apply collections ncbipopper-close-button" type="submit" cmd="AddToCollections">Add to Collections</button></div></div><div><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.FileFormat" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastPresentation" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Presentation" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastPageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Sort" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastSort" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.FileSort" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Format" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastFormat" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PrevPageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PrevPresentation" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PrevSort" sid="1" type="hidden" value="" /><input type="hidden" id="coll_startindex" name="CollectionStartIndex" value="1" /></div></div>
|
||
<div>
|
||
|
||
|
||
|
||
</div>
|
||
<div class="">
|
||
<div><span id="result_sel" class="nowrap"></span><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_ResultsController.ResultCount" sid="1" type="hidden" id="resultcount" value="1" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_ResultsController.RunLastQuery" sid="1" type="hidden" /></div>
|
||
|
||
</div>
|
||
<div id="messagearea" class="empty">
|
||
|
||
|
||
|
||
|
||
</div>
|
||
<div class="rprt full-rprt">
|
||
<div>
|
||
<div class="rprt-header">
|
||
<input type="hidden" id="gene-tax-id" value="9606" />
|
||
<h1 class="title" id="gene-name"><span class="gn" style="padding-right:.5em;">CD4</span> CD4 molecule [ <em class="tax">Homo sapiens</em> (human)
|
||
]
|
||
</h1>
|
||
<span class="geneid">Gene ID: 920, updated on
|
||
4-Mar-2025</span>
|
||
</div>
|
||
<div class="download-datasets">
|
||
<script type="text/javascript" src="https://cdnjs.cloudflare.com/ajax/libs/axios/0.23.0/axios.min.js"></script>
|
||
<h4 class="download-datasets-popper jig-ncbipopper" id="download-asm" style="align-self:start" data-jigconfig="triggerPosition:'bottom center', destPosition : 'top center',destSelector : '#download-datasets-popper-menu', hasArrow : false, openEvent : 'click',closeEvent : 'click', isTriggerElementCloseClick: false, groupName: 'entrez_pg', adjustFit:'none'" role="button" aria-expanded="false" aria-haspopup="true">
|
||
<svg alt="download" class="dlbtn-icon" x="0px" y="0px" width="15px" height="15px" viewBox="0 0 60 60" enable-background="new 0 0 60 60" xml:space="preserve">
|
||
<g>
|
||
<polygon points="48.75,36.25 48.75,48.75 11.25,48.75 11.25,36.25 5,36.25 5,55 55,55 55,36.25 "></polygon>
|
||
<polygon points="42.5,23.75 36.25,23.75 36.25,5 23.75,5 23.75,23.75 17.5,23.75 30,42.5 "></polygon>
|
||
</g>
|
||
</svg>
|
||
<a href="#">Download Datasets</a>
|
||
</h4>
|
||
<div id="download-datasets-popper-menu" style="display:none;">
|
||
<div class="input-group">
|
||
<input type="checkbox" id="datasets-ft-gene-seq-fasta" value="FASTA_GENE" checked="checked" class="download-datasets-included-seq" />
|
||
<label for="datasets-ft-gene-seq-fasta">Gene Sequences (FASTA)</label>
|
||
</div>
|
||
<div class="input-group">
|
||
<input type="checkbox" id="datasets-ft-transcript-seq-fasta" value="FASTA_RNA" class="download-datasets-included-seq" />
|
||
<label for="datasets-ft-transcript-seq-fasta">Transcript sequences (FASTA)</label>
|
||
</div>
|
||
<div class="input-group">
|
||
<input type="checkbox" id="datasets-ft-protein-seq-fasta" value="FASTA_PROTEIN" class="download-datasets-included-seq" />
|
||
<label for="datasets-ft-protein-seq-fasta">Protein sequences(FASTA)</label>
|
||
</div>
|
||
<p style="margin-left:5px;">In addition, your package will include a detailed data report in both TSV and JSONL formats.</p>
|
||
<div class="input-group">
|
||
<label for="datasets-download-file-name">File name</label>
|
||
<input type="text" id="datasets-download-file-name" placeholder="Name your file" style="padding:5px;" value="CD4_datasets.zip" />
|
||
</div>
|
||
<input type="hidden" id="download-datasets-base-url" value="https://api.ncbi.nlm.nih.gov/datasets/v2alpha/gene/download" />
|
||
<input type="hidden" id="gene-id-value" value="920" />
|
||
<button id="datasets-download-submit" data-ga-action="click_begin_download" data-ga-label="download" class="jig-ncbibutton ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-gray" role="button">
|
||
<span class="ui-button-text">Download</span>
|
||
</button>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-body">
|
||
|
||
|
||
<div class="rprt-section gene-summary">
|
||
<section class="rprt-section-header" id="summary">
|
||
<h2 id="header-summary">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-summary .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Summary</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Summary_2" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div id="summaryDiv" class="section">
|
||
<dl id="summaryDl">
|
||
<dt class="noline"> Official
|
||
Symbol</dt>
|
||
<dd class="noline">CD4<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
|
||
<dt> Official
|
||
Full Name</dt>
|
||
<dd>CD4 molecule<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
|
||
<dt>Primary source</dt>
|
||
<dd>
|
||
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1678" data-gblink-text="Ensembl">HGNC:HGNC:1678</a>
|
||
</dd>
|
||
<dt>See related</dt>
|
||
<dd>
|
||
<a href="http://www.ensembl.org/id/ENSG00000010610" data-gblink-text="Ensembl" class="genome-browser-link" data-genome-browser-link-sort="5" data-gb-url="http://www.ensembl.org/loc/ENSG00000010610">Ensembl:ENSG00000010610</a>
|
||
<a href="https://www.ncbi.nlm.nih.gov/omim/186940" data-gblink-text="Ensembl" ref="ordinalpos=1&ncbi_uid=920&link_uid=186940">MIM:186940;</a>
|
||
<a href="https://www.alliancegenome.org/gene/HGNC:1678" data-gblink-text="Ensembl" ref="ordinalpos=1&ncbi_uid=920&link_uid=HGNC:1678">AllianceGenome:HGNC:1678</a>
|
||
</dd>
|
||
<dt>Gene type</dt>
|
||
<dd>protein coding</dd>
|
||
<dt>RefSeq status</dt>
|
||
<dd>REVIEWED</dd>
|
||
<dt>Organism</dt>
|
||
<dd class="tax">
|
||
<a href="/Taxonomy/Browser/wwwtax.cgi?id=9606" ref="ordinalpos=1&ncbi_uid=920&link_uid=9606">Homo sapiens</a>
|
||
</dd>
|
||
<dt>Lineage</dt>
|
||
<dd class="tax">Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo</dd>
|
||
<dt>Also known as</dt>
|
||
<dd>T4; IMD79; Leu-3; OKT4D; CD4mut</dd>
|
||
<dt>Summary</dt>
|
||
<dd>This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, May 2020]</dd>
|
||
<dt>Annotation information</dt>
|
||
<dd>Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for COVID-19 prognosis.</dd>
|
||
<dt>Expression</dt>
|
||
<dd>Broad expression in spleen (RPKM 82.4), lymph node (RPKM 55.1) and 19 other tissues <a href="#gene-expression">See more</a></dd>
|
||
<dt>Orthologs</dt>
|
||
<dd class="ortholog-links">
|
||
<a href="https://www.ncbi.nlm.nih.gov/gene/12504">mouse</a>
|
||
<a href="/gene/920/ortholog/">all</a>
|
||
</dd>
|
||
<dt style="padding-top:.5em;">
|
||
<span class="new-icon">NEW</span>
|
||
</dt>
|
||
<dd style="padding-top:.5em;">
|
||
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/920/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="gene_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Gene table</a></strong>
|
||
<br />
|
||
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/920/products/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="transcript_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Transcript table</a></strong>
|
||
</dd>
|
||
</dl>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-genomic-context">
|
||
<section class="rprt-section-header" id="genomic-context">
|
||
<h2 id="header-genomic-context">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-context .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Genomic context</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Genomic_Context" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div class="gc_cont">
|
||
<div class="gt_cont_contents">
|
||
<div style="float:right"><span>See CD4 in </span><a href="/genome/gdv/?context=gene&acc=920" class="link-to-gdv genome-browser-link" data-genome-browser-link-sort="1" data-acc="GCF_000001405.40">Genome Data Viewer</a> </div>
|
||
<dl class="dl-chr-info" style="float:left;margin-top:0;">
|
||
<dt>Location: </dt>
|
||
<dd>
|
||
<span style="display:inline-block;">12p13.31</span>
|
||
</dd>
|
||
</dl>
|
||
</div>
|
||
<dl class="dl-chr-info exon-count">
|
||
<dt>Exon count: </dt>
|
||
<dd>11</dd>
|
||
</dl>
|
||
<div class="ui-ncbigrid-outer-div" id="genomic-context-tbl-location">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-jigconfig="">
|
||
<thead>
|
||
<tr>
|
||
<th style="max-width:15%">Annotation release</th>
|
||
<th style="max-width:10%">Status</th>
|
||
<th>Assembly</th>
|
||
<th>
|
||
<span title="Chromosome">Chr</span>
|
||
</th>
|
||
<th>Location</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td>RS_2024_08</td>
|
||
<td>current</td>
|
||
<td>GRCh38.p14 (<a href="/assembly/GCF_000001405.40/" ref="ncbi_uid=920&link_uid=GCF_000001405.40">GCF_000001405.40</a>)</td>
|
||
<td>12</td>
|
||
<td>NC_000012.12 (6789528..6820799) </td>
|
||
</tr>
|
||
<tr>
|
||
<td>RS_2024_08</td>
|
||
<td>current</td>
|
||
<td>T2T-CHM13v2.0 (<a href="/assembly/GCF_009914755.1/" ref="ncbi_uid=920&link_uid=GCF_009914755.1">GCF_009914755.1</a>)</td>
|
||
<td>12</td>
|
||
<td>NC_060936.1 (6799096..6830079) </td>
|
||
</tr>
|
||
<tr>
|
||
<td>RS_2024_09</td>
|
||
<td>previous assembly</td>
|
||
<td>GRCh37.p13 (<a href="/assembly/GCF_000001405.25/" ref="ncbi_uid=920&link_uid=GCF_000001405.25">GCF_000001405.25</a>)</td>
|
||
<td>12</td>
|
||
<td>NC_000012.11 (6898694..6929965) </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<p class="withnote margin_t2em"><strong>Chromosome 12 - NC_000012.12</strong><img usemap="#nbrMap920_568815586" border="0" alt="Genomic Context describing neighboring genes" src="/gutils/geneneighb.fcgi?geneid=920&nuc_gi=568815586&n0=LAG3&n1=LOC130007274&n2=LOC127823525&n3=LOC127823526&n4=RN7SL380P&n5=LOC124625896&n6=LOC127823527&n7=CD4&n8=LOC130007275&n9=LOC127823528&n10=LOC127823529&n11=LOC127823530&n12=GPR162&n13=LOC127823531&n14=P3H3&n15=LOC127823532&n16=LOC127823533" /><map name="nbrMap920_568815586" id="nbrMap920_568815586">
|
||
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 4182')" onMouseOut="hidetip()" coords="9,23,79,31" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4182" href="/gene/130007274" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr12:6887480-6888130')" onMouseOut="hidetip()" coords="33,35,103,43" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6887480-6888130" href="/gene/127823525" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:6888131-6888782')" onMouseOut="hidetip()" coords="36,47,106,55" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:6888131-6888782" href="/gene/127823526" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'lymphocyte activating 3')" onMouseOut="hidetip()" coords="42,59,96,67" alt="Neighboring gene lymphocyte activating 3" href="/gene/3902" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'RNA, 7SL, cytoplasmic 380, pseudogene')" onMouseOut="hidetip()" coords="77,71,132,79" alt="Neighboring gene RNA, 7SL, cytoplasmic 380, pseudogene" href="/gene/106479361" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'Sharpr-MPRA regulatory region 1171')" onMouseOut="hidetip()" coords="78,83,148,91" alt="Neighboring gene Sharpr-MPRA regulatory region 1171" href="/gene/124625896" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:6898178-6898735')" onMouseOut="hidetip()" coords="90,23,160,31" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:6898178-6898735" href="/gene/127823527" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 5883')" onMouseOut="hidetip()" coords="109,35,179,43" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5883" href="/gene/130007275" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr12:6928026-6928526')" onMouseOut="hidetip()" coords="249,23,319,31" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6928026-6928526" href="/gene/127823528" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr12:6928527-6929027')" onMouseOut="hidetip()" coords="252,35,322,43" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6928527-6929027" href="/gene/127823529" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr12:6929998-6930970')" onMouseOut="hidetip()" coords="260,59,330,67" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6929998-6930970" href="/gene/127823530" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr12:6936229-6936797')" onMouseOut="hidetip()" coords="293,71,363,79" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6936229-6936797" href="/gene/127823531" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'G protein-coupled receptor 162')" onMouseOut="hidetip()" coords="295,83,357,91" alt="Neighboring gene G protein-coupled receptor 162" href="/gene/27239" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac hESC enhancer GRCh37_chr12:6937955-6938455')" onMouseOut="hidetip()" coords="302,95,372,103" alt="Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:6937955-6938455" href="/gene/127823532" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr12:6938503-6939038')" onMouseOut="hidetip()" coords="305,107,375,115" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6938503-6939038" href="/gene/127823533" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'prolyl 3-hydroxylase 3')" onMouseOut="hidetip()" coords="340,23,423,31" alt="Neighboring gene prolyl 3-hydroxylase 3" href="/gene/10536" />
|
||
</map>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-genomic-regions-transcripts-products">
|
||
<section class="rprt-section-header" id="genomic-regions-transcripts-products">
|
||
<h2 id="header-genomic-regions-transcripts-products">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-regions-transcripts-products .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Genomic regions, transcripts, and products</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Genomic_Regions_Transcripts_a" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div>
|
||
<div style="text-align:right;">Go to <a href="#reference-sequences">reference sequence details</a></div>
|
||
</div>
|
||
<div>
|
||
<p class="choose">
|
||
<label for="accession" class="label">Genomic Sequence: </label>
|
||
<select name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.accessionList" sid="1" id="accessionList" data-taxid="9606" data-geneid="920">
|
||
<option value="NC_000012.12_6789527_6820798">NC_000012.12 Chromosome 12 Reference GRCh38.p14 Primary Assembly</option>
|
||
<option value="NG_027688.2_5001_36272">NG_027688.2 RefSeqGene</option>
|
||
<option value="NC_060936.1_6799095_6830078">NC_060936.1 Chromosome 12 Alternate T2T-CHM13v2.0</option>
|
||
<option value="NC_000012.11_6898693_6929964">NC_000012.11 Chromosome 12 Reference GRCh37.p13 Primary Assembly</option>
|
||
<option value="NW_003871083.2_1121_22384">NW_003871083.2 Chromosome 12 Reference GRCh37.p13 PATCHES</option>
|
||
</select>
|
||
</p>
|
||
</div>
|
||
<div id="NC_000012" class="divAccession">
|
||
<div class="seq-viewer">
|
||
<p class="note-link">
|
||
<strong>Go to nucleotide:</strong>
|
||
<a title="Nucleotide Graphic report" href="/nuccore/NC_000012.12?report=graph&from=6784836&to=6825489&app_context=Gene&assm_context=GCF_000001405.40" ref="ordinalpos=1&ncbi_uid=920&link_uid=NC_000012.12">Graphics</a>
|
||
<a title="Nucleotide FASTA report" href="/nuccore/NC_000012.12?report=fasta&from=6789528&to=6820799" ref="ordinalpos=1&ncbi_uid=920&link_uid=NC_000012.12">FASTA</a>
|
||
<a title="Nucleotide GenBank report" href="/nuccore/NC_000012.12?report=genbank&from=6789528&to=6820799" ref="ordinalpos=1&ncbi_uid=920&link_uid=NC_000012.12">GenBank</a>
|
||
</p>
|
||
<div id="divNC_000012" class="SeqViewerApp" style="clear:both;" data-sv="appname=ncbigene&embedded=true&noslider=1&id=NC_000012.12&from=6784836&to=6825489&app_context=Gene&assm_context=GCF_000001405.40">
|
||
<a href="?appname=ncbigene&embedded=true&noslider=1&id=NC_000012.12&from=6784836&to=6825489&app_context=Gene&assm_context=GCF_000001405.40"></a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000012.12" sid="1" type="hidden" id="nucleotideLink_NC_000012_12_6789527_6820798" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NC_000012.12?report=graph&amp;from=6784836&amp;to=6825489&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" ref="ordinalpos=1&amp;ncbi_uid=920&amp;link_uid=NC_000012.12">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NC_000012.12?report=fasta&amp;from=6789528&amp;to=6820799" ref="ordinalpos=1&amp;ncbi_uid=920&amp;link_uid=NC_000012.12">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NC_000012.12?report=genbank&amp;from=6789528&amp;to=6820799" ref="ordinalpos=1&amp;ncbi_uid=920&amp;link_uid=NC_000012.12">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000012.12" sid="1" type="hidden" id="relString_NC_000012_12_6789527_6820798" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000012.12&amp;from=6784836&amp;to=6825489&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NG_027688.2" sid="1" type="hidden" id="nucleotideLink_NG_027688_2_5001_36272" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NG_027688.2?report=graph&amp;from=310&amp;to=40963&amp;tracks=[key:sequence_track,name:Sequence,display_name:Sequence,category:Sequence,annots:Sequence,ShowLabel:false][key:gene_model_track,name:Genes---Unnamed,display_name:Genes,annots:Unnamed,Options:ShowAllButGenes,SNPs:false,CDSProductFeats:false,ShowLabelsForAllFeatures:true,HighlightMode:2][key:SNP_track,name:SNP,annots:SNP,Layout:Adaptive][key:SNP_Bins_track,name:Clinical Variants][key:SNP_Bins_track,name:Cited Variants][key:GWAS_track,name:GWAS Tracks,display_name:Association Results][key:alignment_track,category:Alignments,annots:Unnamed][key:alignment_track,category:Alignments,annots:NA000079160.1][key:alignment_track,category:Alignments,annots:NA000010065.1]" ref="ordinalpos=1&amp;ncbi_uid=920&amp;link_uid=NG_027688.2">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NG_027688.2?report=fasta&amp;from=5002&amp;to=36273" ref="ordinalpos=1&amp;ncbi_uid=920&amp;link_uid=NG_027688.2">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NG_027688.2?report=genbank&amp;from=5002&amp;to=36273" ref="ordinalpos=1&amp;ncbi_uid=920&amp;link_uid=NG_027688.2">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NG_027688.2" sid="1" type="hidden" id="relString_NG_027688_2_5001_36272" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NG_027688.2&amp;from=310&amp;to=40963&amp;tracks=[key:sequence_track,name:Sequence,display_name:Sequence,category:Sequence,annots:Sequence,ShowLabel:false][key:gene_model_track,name:Genes---Unnamed,display_name:Genes,annots:Unnamed,Options:ShowAllButGenes,SNPs:false,CDSProductFeats:false,ShowLabelsForAllFeatures:true,HighlightMode:2][key:SNP_track,name:SNP,annots:SNP,Layout:Adaptive][key:SNP_Bins_track,name:Clinical Variants][key:SNP_Bins_track,name:Cited Variants][key:GWAS_track,name:GWAS Tracks,display_name:Association Results][key:alignment_track,category:Alignments,annots:Unnamed][key:alignment_track,category:Alignments,annots:NA000079160.1][key:alignment_track,category:Alignments,annots:NA000010065.1]" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_060936.1" sid="1" type="hidden" id="nucleotideLink_NC_060936_1_6799095_6830078" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NC_060936.1?report=graph&amp;from=6794448&amp;to=6834725&amp;app_context=Gene&amp;assm_context=GCF_009914755.1" ref="ordinalpos=1&amp;ncbi_uid=920&amp;link_uid=NC_060936.1">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NC_060936.1?report=fasta&amp;from=6799096&amp;to=6830079" ref="ordinalpos=1&amp;ncbi_uid=920&amp;link_uid=NC_060936.1">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NC_060936.1?report=genbank&amp;from=6799096&amp;to=6830079" ref="ordinalpos=1&amp;ncbi_uid=920&amp;link_uid=NC_060936.1">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_060936.1" sid="1" type="hidden" id="relString_NC_060936_1_6799095_6830078" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_060936.1&amp;from=6794448&amp;to=6834725&amp;app_context=Gene&amp;assm_context=GCF_009914755.1" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000012.11" sid="1" type="hidden" id="nucleotideLink_NC_000012_11_6898693_6929964" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NC_000012.11?report=graph&amp;from=6894002&amp;to=6934655&amp;app_context=Gene&amp;assm_context=GCF_000001405.25" ref="ordinalpos=1&amp;ncbi_uid=920&amp;link_uid=NC_000012.11">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NC_000012.11?report=fasta&amp;from=6898694&amp;to=6929965" ref="ordinalpos=1&amp;ncbi_uid=920&amp;link_uid=NC_000012.11">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NC_000012.11?report=genbank&amp;from=6898694&amp;to=6929965" ref="ordinalpos=1&amp;ncbi_uid=920&amp;link_uid=NC_000012.11">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000012.11" sid="1" type="hidden" id="relString_NC_000012_11_6898693_6929964" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000012.11&amp;from=6894002&amp;to=6934655&amp;app_context=Gene&amp;assm_context=GCF_000001405.25" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NW_003871083.2" sid="1" type="hidden" id="nucleotideLink_NW_003871083_2_1121_22384" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NW_003871083.2?report=graph&amp;from=1&amp;to=25573&amp;app_context=Gene&amp;assm_context=GCF_000001405.25" ref="ordinalpos=1&amp;ncbi_uid=920&amp;link_uid=NW_003871083.2">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NW_003871083.2?report=fasta&amp;from=1122&amp;to=22385" ref="ordinalpos=1&amp;ncbi_uid=920&amp;link_uid=NW_003871083.2">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NW_003871083.2?report=genbank&amp;from=1122&amp;to=22385" ref="ordinalpos=1&amp;ncbi_uid=920&amp;link_uid=NW_003871083.2">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NW_003871083.2" sid="1" type="hidden" id="relString_NW_003871083_2_1121_22384" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NW_003871083.2&amp;from=1&amp;to=25573&amp;app_context=Gene&amp;assm_context=GCF_000001405.25" />
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-gene-expression">
|
||
<section class="rprt-section-header" id="gene-expression">
|
||
<h2 id="header-gene-expression">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-gene-expression .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Expression</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Expression" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div>
|
||
<div style="text-align:right;">
|
||
<a href="/gene/920/?report=expression" data-url="/gene/920/?report=expression" id="gene-expression-see-details">See details</a>
|
||
</div>
|
||
<div id="gene-expression-app" data-url="https://www.ncbi.nlm.nih.gov/gene/920" data-report-type="summary">
|
||
<div>
|
||
<script type="text/javascript">
|
||
|
||
window.tissues_data = {'adrenal 10wk': {'id': '920_Adrenal_10wk_PRJNA270632', 'gene': 920, 'source_name': 'adrenal 10wk', 'full_rpkm': 0.438253, 'exp_rpkm': 0.438, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389212119042}, 'adrenal 16wk': {'id': '920_Adrenal_16wk_PRJNA270632', 'gene': 920, 'source_name': 'adrenal 16wk', 'full_rpkm': 0.560603, 'exp_rpkm': 0.561, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389212119043}, 'adrenal 18wk': {'id': '920_Adrenal_18wk_PRJNA270632', 'gene': 920, 'source_name': 'adrenal 18wk', 'full_rpkm': 0.620704, 'exp_rpkm': 0.621, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389212119044}, 'adrenal 20wk': {'id': '920_Adrenal_20wk_PRJNA270632', 'gene': 920, 'source_name': 'adrenal 20wk', 'full_rpkm': 0.964236, 'exp_rpkm': 0.964, 'var': 0.1550218, 'project_desc': 'PRJNA270632', '_version_': 1785734389212119045}, 'heart 10wk': {'id': '920_Heart_10wk;_PRJNA270632', 'gene': 920, 'source_name': 'heart 10wk', 'full_rpkm': 0.955266, 'exp_rpkm': 0.955, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389212119046}, 'heart 11wk': {'id': '920_Heart_11wk;_PRJNA270632', 'gene': 920, 'source_name': 'heart 11wk', 'full_rpkm': 0.426036, 'exp_rpkm': 0.426, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389212119047}, 'heart 17wk': {'id': '920_Heart_17wk;_PRJNA270632', 'gene': 920, 'source_name': 'heart 17wk', 'full_rpkm': 0.29457, 'exp_rpkm': 0.295, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389212119048}, 'heart 18wk': {'id': '920_Heart_18wk;_PRJNA270632', 'gene': 920, 'source_name': 'heart 18wk', 'full_rpkm': 0.39275, 'exp_rpkm': 0.393, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389212119049}, 'heart 20wk': {'id': '920_Heart_20wk_PRJNA270632', 'gene': 920, 'source_name': 'heart 20wk', 'full_rpkm': 0.304633, 'exp_rpkm': 0.305, 'var': 0.00565245, 'project_desc': 'PRJNA270632', '_version_': 1785734389212119050}, 'intestine 10wk': {'id': '920_Intestine_10wk_PRJNA270632', 'gene': 920, 'source_name': 'intestine 10wk', 'full_rpkm': 0.55628, 'exp_rpkm': 0.556, 'var': 0.0235266, 'project_desc': 'PRJNA270632', '_version_': 1785734389212119051}, 'intestine 11wk': {'id': '920_Intestine_11wk_PRJNA270632', 'gene': 920, 'source_name': 'intestine 11wk', 'full_rpkm': 0.88485, 'exp_rpkm': 0.885, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389212119052}, 'intestine 15wk': {'id': '920_Intestine_15wk_PRJNA270632', 'gene': 920, 'source_name': 'intestine 15wk', 'full_rpkm': 2.12115, 'exp_rpkm': 2.12, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389212119053}, 'intestine 17wk': {'id': '920_Intestine_17wk_PRJNA270632', 'gene': 920, 'source_name': 'intestine 17wk', 'full_rpkm': 1.93397, 'exp_rpkm': 1.93, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389212119054}, 'intestine 20wk': {'id': '920_Intestine_20wk_PRJNA270632', 'gene': 920, 'source_name': 'intestine 20wk', 'full_rpkm': 2.53848, 'exp_rpkm': 2.54, 'var': 0.384386, 'project_desc': 'PRJNA270632', '_version_': 1785734389212119055}, 'kidney 10wk': {'id': '920_Kidney_10wk_PRJNA270632', 'gene': 920, 'source_name': 'kidney 10wk', 'full_rpkm': 0.999177, 'exp_rpkm': 0.999, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389212119056}, 'kidney 16wk': {'id': '920_Kidney_16wk_PRJNA270632', 'gene': 920, 'source_name': 'kidney 16wk', 'full_rpkm': 0.699745, 'exp_rpkm': 0.7, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389212119057}, 'kidney 20wk': {'id': '920_Kidney_20wk_PRJNA270632', 'gene': 920, 'source_name': 'kidney 20wk', 'full_rpkm': 0.619526, 'exp_rpkm': 0.62, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389212119058}, 'lung 10wk': {'id': '920_Lung_10wk_PRJNA270632', 'gene': 920, 'source_name': 'lung 10wk', 'full_rpkm': 3.98392, 'exp_rpkm': 3.98, 'var': 0.1381928, 'project_desc': 'PRJNA270632', '_version_': 1785734389212119059}, 'lung 17wk': {'id': '920_Lung_17wk_PRJNA270632', 'gene': 920, 'source_name': 'lung 17wk', 'full_rpkm': 7.58209, 'exp_rpkm': 7.58, 'var': 0.25927, 'project_desc': 'PRJNA270632', '_version_': 1785734389212119060}, 'lung 20wk': {'id': '920_Lung_20wk_PRJNA270632', 'gene': 920, 'source_name': 'lung 20wk', 'full_rpkm': 6.72863, 'exp_rpkm': 6.73, 'var': 1.194104, 'project_desc': 'PRJNA270632', '_version_': 1785734389213167616}, 'stomach 10wk': {'id': '920_Stomach_10wk_PRJNA270632', 'gene': 920, 'source_name': 'stomach 10wk', 'full_rpkm': 1.0102, 'exp_rpkm': 1.01, 'var': 0.0615794, 'project_desc': 'PRJNA270632', '_version_': 1785734389213167617}, 'stomach 16wk': {'id': '920_Stomach_16wk_PRJNA270632', 'gene': 920, 'source_name': 'stomach 16wk', 'full_rpkm': 1.11011, 'exp_rpkm': 1.11, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389213167618}, 'stomach 18wk': {'id': '920_Stomach_18wk_PRJNA270632', 'gene': 920, 'source_name': 'stomach 18wk', 'full_rpkm': 1.76557, 'exp_rpkm': 1.77, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389213167619}, 'stomach 20wk': {'id': '920_Stomach_20wk_PRJNA270632', 'gene': 920, 'source_name': 'stomach 20wk', 'full_rpkm': 1.79071, 'exp_rpkm': 1.79, 'var': 1.141128, 'project_desc': 'PRJNA270632', '_version_': 1785734389213167620}};
|
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window.details_data = {"adrenal 10wk": [{"id": "metadata_9606_SAMN03267754", "gene": 920, "sample_id": "SAMN03267754", "full_rpkm": 0.438253, "exp_rpkm": 0.438, "exp_total": 7665, "project_desc": "PRJNA270632", "_version_": 1785734387345653765, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "adrenal 10wk", "exp_Mcount": 4852.92}], "adrenal 16wk": [{"id": "metadata_9606_SAMN03267755", "gene": 920, "sample_id": "SAMN03267755", "full_rpkm": 0.560603, "exp_rpkm": 0.561, "exp_total": 14687, "project_desc": "PRJNA270632", "_version_": 1785734387345653764, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "adrenal 16wk", "exp_Mcount": 7269.31}], "adrenal 18wk": [{"id": "metadata_9606_SAMN03267761", "gene": 920, "sample_id": "SAMN03267761", "full_rpkm": 0.620704, "exp_rpkm": 0.621, "exp_total": 14933, "project_desc": "PRJNA270632", "_version_": 1785734387345653763, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "adrenal 18wk", "exp_Mcount": 6675.41}], "adrenal 20wk": [{"id": "metadata_9606_SAMN03267762", "gene": 920, "sample_id": "SAMN03267762", "full_rpkm": 1.35796, "exp_rpkm": 1.36, "exp_total": 37008, "project_desc": "PRJNA270632", "_version_": 1785734387345653761, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "adrenal 20wk", "exp_Mcount": 7561.75}, {"id": "metadata_9606_SAMN03267753", "gene": 920, "sample_id": "SAMN03267753", "full_rpkm": 0.570509, "exp_rpkm": 0.571, "exp_total": 13669, "project_desc": "PRJNA270632", "_version_": 1785734387345653762, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "adrenal 20wk", "exp_Mcount": 6647.98}], "heart 10wk": [{"id": "metadata_9606_SAMN03267750", "gene": 920, "sample_id": "SAMN03267750", "full_rpkm": 0.955266, "exp_rpkm": 0.955, "exp_total": 18385, "project_desc": "PRJNA270632", "_version_": 1785734387345653760, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 10wk", "exp_Mcount": 5340.16}], "heart 11wk": [{"id": "metadata_9606_SAMN03267763", "gene": 920, "sample_id": "SAMN03267763", "full_rpkm": 0.426036, "exp_rpkm": 0.426, "exp_total": 9116, "project_desc": "PRJNA270632", "_version_": 1785734387344605210, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 11wk", "exp_Mcount": 5937.09}], "heart 17wk": [{"id": "metadata_9606_SAMN03267757", "gene": 920, "sample_id": "SAMN03267757", "full_rpkm": 0.29457, "exp_rpkm": 0.295, "exp_total": 8395, "project_desc": "PRJNA270632", "_version_": 1785734387344605209, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 17wk", "exp_Mcount": 7907.66}], "heart 18wk": [{"id": "metadata_9606_SAMN03267751", "gene": 920, "sample_id": "SAMN03267751", "full_rpkm": 0.39275, "exp_rpkm": 0.393, "exp_total": 9032, "project_desc": "PRJNA270632", "_version_": 1785734387344605208, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 18wk", "exp_Mcount": 6380.91}], "heart 20wk": [{"id": "metadata_9606_SAMN03267756", "gene": 920, "sample_id": "SAMN03267756", "full_rpkm": 0.203187, "exp_rpkm": 0.203, "exp_total": 7950, "project_desc": "PRJNA270632", "_version_": 1785734387344605205, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 20wk", "exp_Mcount": 10856.4}, {"id": "metadata_9606_SAMN03267764", "gene": 920, "sample_id": "SAMN03267764", "full_rpkm": 0.382928, "exp_rpkm": 0.383, "exp_total": 7035, "project_desc": "PRJNA270632", "_version_": 1785734387344605206, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 20wk", "exp_Mcount": 5097.56}, {"id": "metadata_9606_SAMN03267760", "gene": 920, "sample_id": "SAMN03267760", "full_rpkm": 0.327785, "exp_rpkm": 0.328, "exp_total": 7081, "project_desc": "PRJNA270632", "_version_": 1785734387344605207, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 20wk", "exp_Mcount": 5994.06}], "intestine 10wk": [{"id": "metadata_9606_SAMN03267752", "gene": 920, "sample_id": "SAMN03267752", "full_rpkm": 0.709663, "exp_rpkm": 0.71, "exp_total": 19972, "project_desc": "PRJNA270632", "_version_": 1785734387344605203, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 10wk", "exp_Mcount": 7808.8}, {"id": "metadata_9606_SAMN03267759", "gene": 920, "sample_id": "SAMN03267759", "full_rpkm": 0.402896, "exp_rpkm": 0.403, "exp_total": 10029, "project_desc": "PRJNA270632", "_version_": 1785734387344605204, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 10wk", "exp_Mcount": 6906.84}], "intestine 11wk": [{"id": "metadata_9606_SAMN03267758", "gene": 920, "sample_id": "SAMN03267758", "full_rpkm": 0.88485, "exp_rpkm": 0.885, "exp_total": 13824, "project_desc": "PRJNA270632", "_version_": 1785734387344605202, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 11wk", "exp_Mcount": 4334.9}], "intestine 15wk": [{"id": "metadata_9606_SAMN03267775", "gene": 920, "sample_id": "SAMN03267775", "full_rpkm": 2.12115, "exp_rpkm": 2.12, "exp_total": 30429, "project_desc": "PRJNA270632", "_version_": 1785734387344605201, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 15wk", "exp_Mcount": 3980.45}], "intestine 17wk": [{"id": "metadata_9606_SAMN03267782", "gene": 920, "sample_id": "SAMN03267782", "full_rpkm": 1.93397, "exp_rpkm": 1.93, "exp_total": 67370, "project_desc": "PRJNA270632", "_version_": 1785734387344605200, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 17wk", "exp_Mcount": 9665.65}], "intestine 20wk": [{"id": "metadata_9606_SAMN03267766", "gene": 920, "sample_id": "SAMN03267766", "full_rpkm": 1.91849, "exp_rpkm": 1.92, "exp_total": 28772, "project_desc": "PRJNA270632", "_version_": 1785734387344605198, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 20wk", "exp_Mcount": 4161.26}, {"id": "metadata_9606_SAMN03267769", "gene": 920, "sample_id": "SAMN03267769", "full_rpkm": 3.15847, "exp_rpkm": 3.16, "exp_total": 44326, "project_desc": "PRJNA270632", "_version_": 1785734387344605199, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 20wk", "exp_Mcount": 3894.01}], "kidney 10wk": [{"id": "metadata_9606_SAMN03267784", "gene": 920, "sample_id": "SAMN03267784", "full_rpkm": 0.999177, "exp_rpkm": 0.999, "exp_total": 17017, "project_desc": "PRJNA270632", "_version_": 1785734387344605197, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "kidney 10wk", "exp_Mcount": 4725.59}], "kidney 16wk": [{"id": "metadata_9606_SAMN03267772", "gene": 920, "sample_id": "SAMN03267772", "full_rpkm": 0.699745, "exp_rpkm": 0.7, "exp_total": 38555, "project_desc": "PRJNA270632", "_version_": 1785734387344605196, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "kidney 16wk", "exp_Mcount": 15288.2}], "kidney 20wk": [{"id": "metadata_9606_SAMN03267777", "gene": 920, "sample_id": "SAMN03267777", "full_rpkm": 0.619526, "exp_rpkm": 0.62, "exp_total": 22953, "project_desc": "PRJNA270632", "_version_": 1785734387344605195, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "kidney 20wk", "exp_Mcount": 10280.0}], "lung 10wk": [{"id": "metadata_9606_SAMN03267770", "gene": 920, "sample_id": "SAMN03267770", "full_rpkm": 4.35566, "exp_rpkm": 4.36, "exp_total": 93445, "project_desc": "PRJNA270632", "_version_": 1785734387344605193, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 10wk", "exp_Mcount": 5952.75}, {"id": "metadata_9606_SAMN03267767", "gene": 920, "sample_id": "SAMN03267767", "full_rpkm": 3.61217, "exp_rpkm": 3.61, "exp_total": 68102, "project_desc": "PRJNA270632", "_version_": 1785734387344605194, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 10wk", "exp_Mcount": 5231.26}], "lung 17wk": [{"id": "metadata_9606_SAMN03267778", 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"full_rpkm": 7.82138, "exp_rpkm": 7.82, "exp_total": 179067, "project_desc": "PRJNA270632", "_version_": 1785734387344605190, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 20wk", "exp_Mcount": 6352.54}], "stomach 10wk": [{"id": "metadata_9606_SAMN03267773", "gene": 920, "sample_id": "SAMN03267773", "full_rpkm": 0.762048, "exp_rpkm": 0.762, "exp_total": 18077, "project_desc": "PRJNA270632", "_version_": 1785734387344605187, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 10wk", "exp_Mcount": 6582.02}, {"id": "metadata_9606_SAMN03267779", "gene": 920, "sample_id": "SAMN03267779", "full_rpkm": 1.25835, "exp_rpkm": 1.26, "exp_total": 32807, "project_desc": "PRJNA270632", "_version_": 1785734387344605188, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 10wk", "exp_Mcount": 7234.02}], "stomach 16wk": [{"id": "metadata_9606_SAMN03267774", "gene": 920, "sample_id": "SAMN03267774", "full_rpkm": 1.11011, "exp_rpkm": 1.11, "exp_total": 24883, "project_desc": "PRJNA270632", "_version_": 1785734387344605186, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 16wk", "exp_Mcount": 6219.43}], "stomach 18wk": [{"id": "metadata_9606_SAMN03267771", "gene": 920, "sample_id": "SAMN03267771", "full_rpkm": 1.76557, "exp_rpkm": 1.77, "exp_total": 37036, "project_desc": "PRJNA270632", "_version_": 1785734387344605185, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 18wk", "exp_Mcount": 5820.42}], "stomach 20wk": [{"id": "metadata_9606_SAMN03267765", "gene": 920, "sample_id": "SAMN03267765", "full_rpkm": 3.30142, "exp_rpkm": 3.3, "exp_total": 53478, "project_desc": "PRJNA270632", "_version_": 1785734387342508032, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 20wk", "exp_Mcount": 4494.58}, {"id": "metadata_9606_SAMN03267781", "gene": 920, "sample_id": "SAMN03267781", "full_rpkm": 1.03587, "exp_rpkm": 1.04, "exp_total": 17047, "project_desc": "PRJNA270632", "_version_": 1785734387343556608, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 20wk", "exp_Mcount": 4566.24}, {"id": "metadata_9606_SAMN03267783", "gene": 920, "sample_id": "SAMN03267783", "full_rpkm": 1.03484, "exp_rpkm": 1.03, "exp_total": 17919, "project_desc": "PRJNA270632", "_version_": 1785734387344605184, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 20wk", "exp_Mcount": 4804.58}]}
|
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window.taxId = 9606
|
||
</script>
|
||
|
||
|
||
<div>
|
||
|
||
|
||
|
||
<select name="p" id="project-selector">
|
||
|
||
|
||
<option value="SRP051249" selected="selected" data-bioproject="PRJNA270632">
|
||
|
||
Tissue-specific circular RNA induction during human fetal development
|
||
|
||
</option>
|
||
|
||
|
||
|
||
<option value="SRP056969" data-bioproject="PRJNA280600">
|
||
|
||
RNA sequencing of total RNA from 20 human tissues
|
||
|
||
|
||
</option>
|
||
|
||
|
||
|
||
<option value="ERP003613" data-bioproject="PRJEB4337">
|
||
|
||
HPA RNA-seq normal tissues
|
||
|
||
|
||
</option>
|
||
|
||
|
||
|
||
</select>
|
||
|
||
|
||
|
||
<ul id="project-summary">
|
||
<li id="project-summary-title">Project title:
|
||
|
||
Tissue-specific circular RNA induction during human fetal development
|
||
|
||
</li>
|
||
|
||
|
||
<li id="project-summary-desc">Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA</li>
|
||
|
||
|
||
|
||
<li id="project-summary-bioprojects">BioProject: <a href="/bioproject/PRJNA270632/">PRJNA270632</a>
|
||
</li>
|
||
|
||
<li id="project-summary-pubs">Publication:
|
||
|
||
|
||
<span><a href="/pubmed/26076956/">PMID 26076956</a></span>
|
||
|
||
</li>
|
||
|
||
|
||
<li id="project-summary-analysis-date">Analysis date: Mon Apr 2 22:54:59 2018</li>
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
<div id="gene-expr-details" class="expression-chart"></div>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<script type="text/javascript" src="https://www.gstatic.com/charts/loader.js"></script>
|
||
<script type="text/javascript">
|
||
google.charts.load('current', {
|
||
'packages':[ 'corechart']
|
||
});
|
||
|
||
</script>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-bibliography">
|
||
<section class="rprt-section-header" id="bibliography"><h2 id="header-bibliography"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-bibliography .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Bibliography</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Bibliography" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
|
||
<div class="rprt-section-body" style="">
|
||
<div class="generif-pubmed">
|
||
<h3 id="relatedarticlesinpubmed">
|
||
<a href="#" class="jig-ncbitoggler-open">Related articles in PubMed</a>
|
||
</h3>
|
||
<div class="generefbl-link">
|
||
<ol class="generef-link">
|
||
<li>
|
||
<a href="/pubmed/21626027/" ref="ordinalpos=1&ncbi_uid=920&link_uid=21626027">Association of CD4 enhancer gene polymorphisms with rheumatoid arthritis in Egyptian female patients.</a>
|
||
<span class="pubmed-auth-date"> Hussein YM, <em>et al</em>. Rheumatol Int, 2012 Aug. PMID 21626027</span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/26339058/" ref="ordinalpos=2&ncbi_uid=920&link_uid=26339058">Phenotypic Correlates of HIV-1 Macrophage Tropism.</a>
|
||
<span class="pubmed-auth-date"> Arrildt KT, <em>et al</em>. J Virol, 2015 Nov. PMID 26339058, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC4645658/" ref="ordinalpos=0&ncbi_uid=920&link_uid=PMC4645658">Free PMC Article</a></span></span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/26362701/" ref="ordinalpos=3&ncbi_uid=920&link_uid=26362701">The role of CD4 on mechanical properties of live cell membrane.</a>
|
||
<span class="pubmed-auth-date"> Bui VC, <em>et al</em>. J Biomed Mater Res A, 2016 Jan. PMID 26362701</span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/11106664/" ref="ordinalpos=4&ncbi_uid=920&link_uid=11106664">T Cell Receptor Binding to a pMHCII Ligand Is Kinetically Distinct from and Independent of CD4.</a>
|
||
<span class="pubmed-auth-date"> Xiong Y, <em>et al</em>. J Biol Chem, 2001 Feb 23. PMID 11106664</span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/15748900/" ref="ordinalpos=5&ncbi_uid=920&link_uid=15748900">Dynamic reorganization of chemokine receptors, cholesterol, lipid rafts, and adhesion molecules to sites of CD4 engagement.</a>
|
||
<span class="pubmed-auth-date"> Nguyen DH, <em>et al</em>. Exp Cell Res, 2005 Apr 1. PMID 15748900</span>
|
||
</li>
|
||
</ol>
|
||
<p class="see-all-pm">
|
||
<a href="/pubmed?LinkName=gene_pubmed&from_uid=920" title="See all 2023 citations in Pubmed">See all (2023) citations in PubMed</a>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="generif-pubmed generif">
|
||
<h3 id="generifsgenereferencesintofunctions">
|
||
<a href="#" class="jig-ncbitoggler-open">GeneRIFs: Gene References Into Functions</a>
|
||
</h3>
|
||
<div>
|
||
<a href="/gene/about-generif" class="whatisthis">What's a GeneRIF?</a>
|
||
<div class="generefbl-link">
|
||
<ol class="generef-link">
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/38415552" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=920&link_uid=38415552">Evaluating CD4 and Foxp3 mRNA Expression in Tissue Specimens of Celiac Disease and Colorectal Cancer Patients.</a>
|
||
<div id="gene-popper1" class="gene-rif-popper">Title: Evaluating CD4 and Foxp3 mRNA Expression in Tissue Specimens of Celiac Disease and Colorectal Cancer Patients.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/38308298" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=920&link_uid=38308298">The relationship between high ratios of CD4/FOXP3 and CD8/CD163 and the improved survivability of metastatic triple-negative breast cancer patients: a multicenter cohort study.</a>
|
||
<div id="gene-popper2" class="gene-rif-popper">Title: The relationship between high ratios of CD4/FOXP3 and CD8/CD163 and the improved survivability of metastatic triple-negative breast cancer patients: a multicenter cohort study.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/37993719" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=920&link_uid=37993719">Intermediate conformations of CD4-bound HIV-1 Env heterotrimers.</a>
|
||
<div id="gene-popper3" class="gene-rif-popper">Title: Intermediate conformations of CD4-bound HIV-1 Env heterotrimers.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/37993716" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=920&link_uid=37993716">HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes.</a>
|
||
<div id="gene-popper4" class="gene-rif-popper">Title: HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/36567293" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=920&link_uid=36567293">Better Predictive Value of Lymphocyte Count and Hemoglobin for CD4 Level of HIV Patients.</a>
|
||
<div id="gene-popper5" class="gene-rif-popper">Title: Better Predictive Value of Lymphocyte Count and Hemoglobin for CD4 Level of HIV Patients.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/37460640" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=920&link_uid=37460640">Stem-cell-like CD4[+] T cells prey on MHC class II-negative tumors.</a>
|
||
<div id="gene-popper6" class="gene-rif-popper">Title: Stem-cell-like CD4(+) T cells prey on MHC class II-negative tumors.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/37169554" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=920&link_uid=37169554">CD4+CD25+CD127[lo]FOXP3+ cell in food allergy: Does it predict anaphylaxis?</a>
|
||
<div id="gene-popper7" class="gene-rif-popper">Title: CD4+CD25+CD127(lo)FOXP3+ cell in food allergy: Does it predict anaphylaxis?</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/36622146" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=920&link_uid=36622146">AP-2 Adaptor Complex-Dependent Enhancement of HIV-1 Replication by Nef in the Absence of the Nef/AP-2 Targets SERINC5 and CD4.</a>
|
||
<div id="gene-popper8" class="gene-rif-popper">Title: AP-2 Adaptor Complex-Dependent Enhancement of HIV-1 Replication by Nef in the Absence of the Nef/AP-2 Targets SERINC5 and CD4.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/36674807" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=920&link_uid=36674807">Lack of Association between Common LAG3/CD4 Variants and Risk of Migraine.</a>
|
||
<div id="gene-popper9" class="gene-rif-popper">Title: Lack of Association between Common LAG3/CD4 Variants and Risk of Migraine.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/36499569" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=920&link_uid=36499569">Association between LAG3/CD4 Genes Variants and Risk for Multiple Sclerosis.</a>
|
||
<div id="gene-popper10" class="gene-rif-popper">Title: Association between LAG3/CD4 Genes Variants and Risk for Multiple Sclerosis.</div>
|
||
</li>
|
||
</ol>
|
||
</div>
|
||
<div class="submit-genrif">
|
||
<span>Submit:</span>
|
||
<a href="/gene/submit-generif/?geneId=920&sym=CD4&name=CD4 molecule&org=Homo sapiens">New GeneRIF</a>
|
||
<a href="/RefSeq/update.cgi?geneid=920&symbol=CD4;task=fixpub">Correction</a>
|
||
<a href="https://www.ncbi.nlm.nih.gov/gene?db=gene&report=generif&term=920" class="seeall-generif">See all GeneRIFs (315)</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-phenotypes">
|
||
<section class="rprt-section-header" id="phenotypes">
|
||
<h2 id="header-phenotypes">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-phenotypes .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Phenotypes</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Phenotype" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body info-phenotype">
|
||
<p class="nochild-link">
|
||
<a href="/gtr/tests/?term=CD4[gene]">Find tests for this gene in the NIH Genetic Testing Registry (GTR)</a>
|
||
</p>
|
||
<p class="nochild-link">
|
||
<a href="/gap/PheGenI?tab=1&gene=920">Review eQTL and phenotype association data in this region using PheGenI</a>
|
||
</p>
|
||
<div>
|
||
<h3 id="associatedconditions">Associated conditions</h3>
|
||
<table class="jig-ncbigrid gtr-associated-cond">
|
||
<thead>
|
||
<tr>
|
||
<th class="description">Description</th>
|
||
<th>Tests</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td>
|
||
<a href="/gtr/conditions/C5543220" ref="ncbi_uid=920&link_uid=C5543220">Immunodeficiency 79</a>
|
||
<div class="gtr-associated-cond-extra">
|
||
<span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C5543220" ref="ncbi_uid=920&link_uid=C5543220">C5543220</a></span>
|
||
<span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/619238" ref="ncbi_uid=920"> 619238</a></span>
|
||
<span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span>
|
||
</div>
|
||
</td>
|
||
<td>
|
||
<span class="gtr-na">not available</span>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td>
|
||
<a href="/gtr/conditions/C3151379" ref="ncbi_uid=920&link_uid=C3151379">Okt4 epitope deficiency</a>
|
||
<div class="gtr-associated-cond-extra">
|
||
<span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C3151379" ref="ncbi_uid=920&link_uid=C3151379">C3151379</a></span>
|
||
<span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/613949" ref="ncbi_uid=920"> 613949</a></span>
|
||
<span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span>
|
||
</div>
|
||
</td>
|
||
<td>
|
||
<a href="/gtr/tests/?term=C3151379[DISCUI]&condition=C3151379&compare_labs=1" ref="ncbi_uid=920">Compare labs</a>
|
||
</td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
<div>
|
||
<h3 id="ebigwascatalog">EBI GWAS Catalog</h3>
|
||
<table class="jig-ncbigrid gtr-associated-cond" data-jigconfig="isPageable: true, pageSize: 10">
|
||
<thead>
|
||
<tr>
|
||
<th class="description">Description</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td>Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/22437554">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/22437554">PubMed</a></span></div></div></div></td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-variation">
|
||
<section class="rprt-section-header" id="variation">
|
||
<h2 id="header-variation">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-variation .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Variation</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.variation" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<p class="nochild-link">
|
||
<a href="/clinvar/?term=CD4[gene]" ref="log$=recordlinks">See variants in ClinVar</a>
|
||
</p>
|
||
<p class="nochild-link">
|
||
<a href="/dbvar?LinkName=gene_dbvar&from_uid=920" ref="log$=recordlinks">See studies and variants in dbVar</a>
|
||
</p>
|
||
<p class="nochild-link">
|
||
<a href="/variation/view/?q=920[geneid]&assm=GCF_000001405.25" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh37.p13)">See Variation Viewer (GRCh37.p13)</a>
|
||
</p>
|
||
<p class="nochild-link">
|
||
<a href="/variation/view/?q=920[geneid]" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh38)">See Variation Viewer (GRCh38)</a>
|
||
</p>
|
||
<set></set>
|
||
<set></set>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-HIV-1-interactions">
|
||
<section class="rprt-section-header" id="HIV-1-interactions">
|
||
<h2 id="header-HIV-1-interactions">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-HIV-1-interactions .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">HIV-1 interactions</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.HIV1_interactions" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div class="fgrid">
|
||
<h3 id="replicationinteractions">Replication interactions</h3>
|
||
<table summary="replication interactions" class="jig-ncbigrid">
|
||
<thead>
|
||
<tr>
|
||
<th id="hivinter">Interaction</th>
|
||
<th id="hivpub">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="hivinter">Macrophage-tropic HIV-1 isolates from patients require less CD4 for entry, but are readily neutralized by soluble CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26339058" href="/pubmed/26339058">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivinter">HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26873986,26439863" href="/pubmed/26873986,26439863">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivinter">HIV-1 infection downregulates CD4 expression in CD4+ T cells from human, pediatric tonsils</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26873986" href="/pubmed/26873986">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivinter">siRNA knockdown of CD4 decreases CCR5-tropic (ADA) and dual-tropic (89.6) pseudotyped virus (luciferase reporter HIV backbone presumed) infection of MDMs, yet does not affect MLV- and VSV-pseudotyped virus infection, as measured by luciferase activity</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25973004" href="/pubmed/25973004">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivinter">siRNA knockdown of CD4 decreases HIV production from monocyte-derived macrophages (MDMs) infected with HIV-1 (SX strain) at a low multiplicity of infection (MOI= 0.02)</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25973004" href="/pubmed/25973004">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivinter">Knockdown of CD4 by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25100719,22404213,18187620" href="/pubmed/25100719,22404213,18187620">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivinter">Knockdown of CD4 by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 18976975" href="/pubmed/18976975">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
<h3 id="proteininteractions">Protein interactions</h3>
|
||
<table summary="protein interactions" class="jig-ncbigrid">
|
||
<thead>
|
||
<tr>
|
||
<th id="hivprotein">Protein</th>
|
||
<th id="gene-hivprotein">Gene</th>
|
||
<th id="hivinter">Interaction</th>
|
||
<th id="hivpub">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/28876544">Envelope surface glycoprotein gp120</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 HXB2 Env binds and fuses to CV-1 cells expressing CD4 and CXCR4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26511606" href="/pubmed/26511606">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 JR-CSF Env mutant E153G binds CD4 with better affinity</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24957778" href="/pubmed/24957778">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Env (gp120) binds to CD4 and is destabilized by lysine based dendrimer SPL7013</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26495445" href="/pubmed/26495445">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Envs utilize CD4/CCR5 with different efficiences according to subtype designation (A, B, C and D)</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24957778" href="/pubmed/24957778">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Env (gp120) binds to CD4 through in silico analysis</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 27535053" href="/pubmed/27535053">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Human C"" beta strand (amino acids 42-47) of CD4, particularly Phe-43, plays a crucial role in HIV-1 coreceptor function as well as in HIV-1 gp120-CD4 binding capacity</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 10779509" href="/pubmed/10779509">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 envelope glycoprotein gp120 binds to the cell surface receptor CD4 or soluble CD4; the carbohydrates present on gp120 are necessary for CD4 binding during HIV-1 entry</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 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href="/pubmed/26903989,26495445,25972534,25880110,25807494,25803681,25762739,25723173,25712564,25704889,25691567,25646817,25631091,25589785,25569556,25555152,25522787,25472996,25462344,25461534,25453804,25378497,25355891,25350851,25339767,25313689,25298114,25296255,25296251,25245278,25231990,25203778,25193376,25174000,25166308,25105502,25031337,25008916,24965460,24965454,24931470,24920809,24920800,24884783,24819826,24804757,24801282,24788065,24778234,24741097,24729094,24661998,24656066,24583235,24558379,24550395,24516533,24498878,24492798,24454812,24441862,24418543,24416431,24390336,24382025,24352455,24352444,24352234,24338530,24312168,24307580,24304511,24284318,24277152,24237700,24179160,24179159,24158961,24157907,24156625,24146829,24145278,24131720,24109227,24075869,24074590,24074567,24029736,24005480,23991039,23989454,23908485,23884589,23884127,23878231,23862963,23840566,23825637,23804632,23777826,23776539,23762317,23757493,23747109,23742646,23711095,23710622,23707685,23692808,23665667,23658524,23616655,23535561,23514633,23468626,23454641,23389465,23375046,23330719,23304142,23300605,23297802,23267106,23255784,23219376,23217618,23211775,23202514,23143844,23135721,23135713,23087226,23086459,23077246,23066870,23055568,23043104,23043103,23011758,22959895,22957718,22947176,22908191,22807678,22745174,22696649,22693444,22687513,22674993,22650962,22624045,22606344,22583677,22553332,22551420,22524483,22497421,22479399,22474613,22470838,22451932,22433250,22422068,22421880,22419808,22414543,22345481,22332354,22312332,22297516,22291921,22291694,22286875,22284192,22266649,22237899,22192629,22178016,22167180,22163344,22124968,22117536,22090143,22083481,22079291,22069466,22031937,22014753,22006924,21994672,21994458,21994452,21962990,21957314,21937655,21931551,21886150,21875413,21851958,21849975,21793507,21763489,21760891,21715496,21697467,21660189,21635737,21613393,21612582,21543479,21488663,21487012,21474836,21465559,21444771,21440555,21411542,21382342,21351734,21325401,21310296,21284899,21249232,21216423,21169023,21159865,21152581,21068257,21041720,20980513,20974843,20969902,20956336,20953943,20943653,20890395,20825246,20730055,20718047,20698725,20681584,20660185,20657663,20624966,20610714,20570309,20558728,20538591,20507591,20501362,20494390,20463957,20420669,20369886,20369301,20357769,20304457,20229778,20227370,20195464,20186035,20166763,20164234,20147388,20088758,20080564,20041213,20016882,20007245,19965434,19926478,19851458,19839582,19837465,19813706,19783140,19763181,19734912,19671162,19661992,19632839,19620004,19567243,19556424,19535453,19478876,19457995,19349871,19208751,19193785,19187599,19180463,19170639,19066282,19020832,19019953,19018669,19004960,19000821,18991615,18977142,18976975,18976462,18952441,18833294,18768967,18715908,18704932,18691022,18672260,18668044,18638381,18632854,18624812,18619974,18594881,18590744,18579609,18566427,18539308,18524826,18480458,18468560,18390744,18378683,18377648,18339756,18322210,18310503,18296630,18242797,18237398,18205925,18187620,18162176,18097956,18045872,18045112,18032634,17980997,17959679,17954689,17901336,17825297,17803292,17728240,17628860,17599917,17485285,17436226,17360741,17346946,17344303,17334223,17320923,17301785,17269928,17263629,17260969,17251303,17239419,17227719,17187670,17158233,17157668,17144914,17132727,17131136,17121788,17118792,17084877,17083721,17050608,17035237,17034868,17030448,17015697,17014923,17006538,17005819,16956948,16912071,16886061,16855325,16844755,16829607,16827663,16817962,16778874,16728975,16725045,16702010,16611061,16611055,16571818,16569857,16437164,16331979,16306611,16300985,16284274,16284180,16282475,16266123,16185162,16182193,16174727,16160142,16148047,16106369,16103167,16051303,16047221,16046522,16014956,16002156,15996703,15990565,15956589,15946678,15893666,15890935,15857997,15857992,15836438,15797855,15795268,15784911,15767435,15729334,15729327,15719026,15665647,15650196,15644496,15613479,15585836,15577644,15572157,15489307,15481145,15308718,15279586,15258189,15215692,15194768,15183057,15180541,15180540,15168796,15131118,15113923,15113900,15109676,15103622,15090827,15051887,15033567,15016894,14967033,14965316,14739941,14659896,14592831,14592765,14592761,14585219,14585209,14576059,14570906,14557624,12970437,12963807,12960231,12943795,12930892,12887918,12885233,12873765,12873764,12871111,12864967,12857973,12829845,12787886,12769725,12768015,12719580,12719560,12714584,12707350,12689412,12646921,12646791,12608057,12597360,12584309,12531788,12505925,12502824,12502809,12487827,12477867,12477840,12438611,12406507,12239168,12218052,12218051,12208966,12191776,12163558,12134256,12120995,12083833,12072528,12033937,12033289,12008044,11967288,11906183,11888657,11878912,11855981,11827520,11804554,11799176,11734627,11704677,11602639,11533181,11517385,11504923,11485409,11462056,11453640,11413337,11413305,11397808,11356967,11356961,11352665,11350667,11333905,11327825,11312658,11311058,11287575,11265761,11264367,11238869,11201791,11118070,11086073,11075952,11069996,11024154,10941932,10922058,10888615,10843204,10816381,10799864,10779509,10774549,10738970,10623764,10623731,10600606,10593874,10590121,10589997,10582593,10581250,10559349,10558884,10557278,10512629,10505674,10446313,10430052,10422873,10393974,10364484,10358157,10356363,10235509,10233996,10213312,10202115,9918507,9862697,9826718,9759876,9739096,9724097,9669555,9658081,9658072,9641677,9637477,9621091,9604776,9600078,9573233,9548463,9525894,9451022,9443108,9426451,9417096,9377118,9349472,9344703,9334377,9274854,9269777,9264287,9261346,9235945,9188565,9186786,9184207,9128743,9123823,9043947,9037057,9036944,9020356,9013955,9002959,9000083,8995609,8995603,8989204,8986758,8985413,8977179,8976200,8973529,8948487,8906988,8906796,8906795,8898753,8892864,8891109,8887682,8883579,8882662,8878430,8875644,8862276,8849450,8827217,8827216,8814265,8811198,8811050,8810998,8806567,8805353,8801439,8798974,8798972,8798971,8794362,8794361,8790377,8760413,8743291,8738430,8726523,8707350,8674119,8671590,8663408,8649438,8648738,8629022,8627711,8627264,8627160,8627018,8623537,8621941,8615032,8605026,8599832,8575195,8560767,8551601,8547064,8537092,8524869,8503188,8497077,8497074,8474162,8466484,8460995,8455141,8438588,8437234,8437224,8421893,8419649,8419169,8417177,8416385,8406619,8369162,8363802,8361381,8341695,8331723,8280475,8218172,8212576,8196669,8178478,8160267,8139032,8139010,8129620,8122371,8086417,8075984,8043225,7935503,7914230,7913036,7906657,7904656,7904351,7904348,7903106,7902128,7897356,7897355,7874384,7867080,7832633,7831801,7821926,7774645,7769687,7754236,7734186,7707502,7693970,7692087,7692037,7690724,7689324,7687306,7686944,7685405,7684821,7678271,7618285,7616571,7592573,7589092,7589091,7576913,7546903,7545244,7545243,7544051,7543586,7543271,7541827,7539755,7537501,7529290,7522245,7521897,7515973,7506556,3682024,3500514,3264307,3261864,3260352,3259291,3037551,3037522,3031162,3029227,2884513,2851650,2846691,2843775,2842778,2824064,2783333,2649653,2574581,2561054,2559777,2558687,2555855,2550679,2543930,2542563,2541915,2537355,2536098,2523711,2482055,2479005,2475780,2465401,2458487,2453925,2441877,2402498,2374593,2364018,2363051,2341717,2335819,2325207,2324685,2261984,2251501,2243375,2212945,2198840,2190605,2190096,2187500,2182910,2171457,2136376,2125484,2115689,2111957,2107024,2103853,2082620,2078409,2078408,2078013,2076345,2068099,2059359,2045792,2040664,2018763,2006155,1995942,1991970,1985197,1983967,1979910,1978941,1977427,1971526,1970124,1967280,1967269,1959561,1931229,1910691,1899141,1889086,1871120,1870209,1870202,1845049,1832782,1810199,1742075,1738091,1736938,1732513,1730924,1727487,1727475,1722676,1721822,1720631,1720590,1717717,1717587,1713252,1711033,1710248,1709701,1706342,1703212,1702842,1702163,1701782,1698964,1698804,1696539,1693676,1691563,1691226,1690236,1685857,1636088,1627247,1614536,1602552,1599754,1588493,1569213,1567578,1563094,1549584,1548769,1548744,1546447,1543562,1512692,1503822,1501286,1500858,1493050,1472279,1465431,1457207,1438278,1402655,1388715,1382339,1381399,1381203,1378510,1376135,1376134,1374095,1373549,1373203,1370558,1356673,1354681,1352879,1348943,1281202,1280382,1279195">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Env (ADA) mutation N197S confers independence from CD4-mediated HIV-1 entry in to host cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26246571" href="/pubmed/26246571">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Env (NL4-3) conformational dynamics and states are stabilized by soluble CD4 [and the coreceptor surrogate antibody 17b]</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25762739" href="/pubmed/25762739">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Enhanced CD4 binding activity of HIV-1 isolate R3A gp120/gp41 contributes to activate plasmacytoid dendritic cells (pDCs)</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25972534" href="/pubmed/25972534">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 interacts with CD4 and CXCR4 to enhance CCR7-dependent human CD4+ T cell migration</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25688986" href="/pubmed/25688986">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 enhances CCL-21-induced CD4+ T cell chemotaxis in a CXCR4- and CD4-dependent manner</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25688986" href="/pubmed/25688986">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HbAHP-25, an analogue of Hb-alpha derived peptide, inhibits CCR5-tropic and CXCR4-tropic HIV-1 strains by blocking the binding of CD4 to HIV-1 gp120 and the subsequent steps leading to entry and/or fusion</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25915507" href="/pubmed/25915507">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Soluble CD4 can bind to HIV-1 gp120 and block HIV-1 infectivity</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25849367,24965454,24284318,24198429,24145278,24131720,23616655,22284360,22117536,21994452,21957314,20494390,20197275,18524826,18045872,17959679,17526486,17413690,16702010,12943795,11827520,11533181,9658072,8906988,8827217,8663408,8510207,8464887,8419649,8363802,8139010,7904656,7904348,7734186,7693970,7690418,7687306,7618285,7592573,2829023,2829022,2550671,2549987,2538505,2341717,2190605,2190604,2078408,2015114,2007979,1977427,1871120,1870209,1727487,1727475,1713252,1693676,1690832,1687500,1674549,1639820,1627247,1605591,1599754,1567578,1563094,1373203,1348943,1281202,1280382" href="/pubmed/25849367,24965454,24284318,24198429,24145278,24131720,23616655,22284360,22117536,21994452,21957314,20494390,20197275,18524826,18045872,17959679,17526486,17413690,16702010,12943795,11827520,11533181,9658072,8906988,8827217,8663408,8510207,8464887,8419649,8363802,8139010,7904656,7904348,7734186,7693970,7690418,7687306,7618285,7592573,2829023,2829022,2550671,2549987,2538505,2341717,2190605,2190604,2078408,2015114,2007979,1977427,1871120,1870209,1727487,1727475,1713252,1693676,1690832,1687500,1674549,1639820,1627247,1605591,1599754,1567578,1563094,1373203,1348943,1281202,1280382">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Anti-CD4 antibodies are capable of neutralizing HIV-1 strains or blocking the binding of HIV-1 envelope glycoprotein gp120 and cell surface receptor CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25810537,25803681,25522326,25341782,25298114,25215485,25058619,24884925,24846288,24758333,23924998,23776539,23692808,23616655,23300605,22553332,22551420,22329717,21994452,21957314,21760891,21660189,21593147,21487012,21382342,21357743,21351734,21289125,21152581,21110955,20860805,20610714,20558728,20507591,20463957,20463063,20357769,19965434,19478876,18704932,18668044,18377648,18296630,18237398,18205925,17721546,17239419,17158233,16702010,16616288,16426633,16106369,15893666,15650196,15321703,15168796,14592765,14505925,12943795,12477840,9739096,8827217,8615032,8497074,8464887,8363802,8196669,7904351,7769687,7690724,7686944,7685405,7592573,7544051,7506554,3260352,3029227,2571187,2555159,2537355,2482055,2461565,2198840,2078408,2040664,1983967,1977427,1888898,1757107,1706342,1702842,1701782,1698911,1691226,1690236,1614536,1503822,1438278,1381399,1381201,1378510,1373203" href="/pubmed/25810537,25803681,25522326,25341782,25298114,25215485,25058619,24884925,24846288,24758333,23924998,23776539,23692808,23616655,23300605,22553332,22551420,22329717,21994452,21957314,21760891,21660189,21593147,21487012,21382342,21357743,21351734,21289125,21152581,21110955,20860805,20610714,20558728,20507591,20463957,20463063,20357769,19965434,19478876,18704932,18668044,18377648,18296630,18237398,18205925,17721546,17239419,17158233,16702010,16616288,16426633,16106369,15893666,15650196,15321703,15168796,14592765,14505925,12943795,12477840,9739096,8827217,8615032,8497074,8464887,8363802,8196669,7904351,7769687,7690724,7686944,7685405,7592573,7544051,7506554,3260352,3029227,2571187,2555159,2537355,2482055,2461565,2198840,2078408,2040664,1983967,1977427,1888898,1757107,1706342,1702842,1701782,1698911,1691226,1690236,1614536,1503822,1438278,1381399,1381201,1378510,1373203">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 with T257S/S375W double mutation is stabilized into the CD4-bound state, with increasing relative fixation between core, full-length monomeric, and full-length trimeric versions of gp120</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25849367,24489681,19813706,17360741" href="/pubmed/25849367,24489681,19813706,17360741">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CD4 binding results in a major reorganization of the gp120 trimer, causing an outward rotation and displacement of each gp120 monomer</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25807248,18668044" href="/pubmed/25807248,18668044">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The CCR5 chemokine receptor is required for the entry of macrophage-tropic HIV-1 into target cells; the HIV-1 gp120-CD4 complex binds CCR5, which inhibits the binding of the natural CCR5 ligands macrophage inflammatory protein (MIP)-1alpha and MIP-1beta</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25880110,25463598,25231990,25193376,25174000,24788065,24454812,24441862,24312168,24307580,24145278,23692808,23616655,23304142,23269796,23217618,23211775,23143844,23043104,23043103,23011758,22947176,22908191,22818780,22783935,22733823,22732432,22693444,22583677,22547820,22470838,22422068,22421880,22297516,22178016,22163344,22157596,21994672,21994458,21793507,21763489,21760891,21647388,21325401,21310296,21284907,21284899,21152581,20657663,20494390,20377425,20229778,20051874,20041213,19692480,19692476,19553323,19170639,19144136,18976462,18833294,18786994,18691022,18672260,18624812,18619974,18590744,18500445,18480458,18310503,18197116,17628860,17507486,17485285,17328229,17239419,17121788,17035237,17030448,16817962,16775320,16753228,16702010,16300985,16282475,16103167,16002156,15983047,15964018,15956589,15890935,15857992,15807900,15784911,15767436,15767435,15321703,15258189,15215692,15194768,15113926,15018709,14990703,14967033,14592765,14517611,14512572,12963807,12960231,12887918,12873765,12871111,12857973,12845769,12692222,12634405,12610158,12441808,12429730,12429712,12392548,12368322,12163558,12120995,11967288,11906183,11884536,11878912,11877445,11876757,11861874,11504923,11489906,11413305,11397808,11356967,11356961,11312658,11265761,11264367,11238869,11201791,11118070,11069996,11024154,10888615,10816381,10774549,10738970,10644351,10623731,10590121,10446313,10393974,9870313,9653051,9632396,9576954,9525683,9445013,9420225,8976200,8906796,8906795,8898753,8805353,8674119" href="/pubmed/25880110,25463598,25231990,25193376,25174000,24788065,24454812,24441862,24312168,24307580,24145278,23692808,23616655,23304142,23269796,23217618,23211775,23143844,23043104,23043103,23011758,22947176,22908191,22818780,22783935,22733823,22732432,22693444,22583677,22547820,22470838,22422068,22421880,22297516,22178016,22163344,22157596,21994672,21994458,21793507,21763489,21760891,21647388,21325401,21310296,21284907,21284899,21152581,20657663,20494390,20377425,20229778,20051874,20041213,19692480,19692476,19553323,19170639,19144136,18976462,18833294,18786994,18691022,18672260,18624812,18619974,18590744,18500445,18480458,18310503,18197116,17628860,17507486,17485285,17328229,17239419,17121788,17035237,17030448,16817962,16775320,16753228,16702010,16300985,16282475,16103167,16002156,15983047,15964018,15956589,15890935,15857992,15807900,15784911,15767436,15767435,15321703,15258189,15215692,15194768,15113926,15018709,14990703,14967033,14592765,14517611,14512572,12963807,12960231,12887918,12873765,12871111,12857973,12845769,12692222,12634405,12610158,12441808,12429730,12429712,12392548,12368322,12163558,12120995,11967288,11906183,11884536,11878912,11877445,11876757,11861874,11504923,11489906,11413305,11397808,11356967,11356961,11312658,11265761,11264367,11238869,11201791,11118070,11069996,11024154,10888615,10816381,10774549,10738970,10644351,10623731,10590121,10446313,10393974,9870313,9653051,9632396,9576954,9525683,9445013,9420225,8976200,8906796,8906795,8898753,8805353,8674119">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CXCR4, a 45kDa cellular membrane protein, interacts with the cell surface HIV-1 gp120-CD4 complex and acts as a coreceptor to preferentially support T cell line-tropic HIV-1 Env-mediated cell fusion and HIV-1 infection</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25880110,25463598,25231990,25193376,24441862,24312168,24145278,24039179,23804632,23692808,23304142,23211775,23143844,23043104,23043103,22947176,22908191,22783935,22732432,22583677,22470838,22422068,22297516,22237899,22226668,22178016,22163344,22157596,21994672,21994458,21760891,21474836,21310296,21284907,21284899,21152581,20967243,20697919,20051874,20041213,19926478,19692474,19493998,18976462,18833294,18691022,18624812,18500445,18310503,18197116,18032634,17507486,17346946,17292399,17251303,17187670,17144914,17121788,16886061,16886053,16227248,16188969,16174727,16103167,16047221,16046522,15990565,15890935,15784911,15748209,15737612,15585836,15258189,15215692,15113923,15113900,15018709,15014135,14990703,14592831,14576059,12963807,12960231,12953261,12873765,12871111,12864967,12857973,12845769,12832058,12713058,12634405,12614324,12502809,12429730,12429712,12402167,12368322,12163558,12120995,11967288,11931835,11884536,11878912,11877445,11876757,11861874,11799176,11752220,11602639,11504923,11489906,11413305,11397808,11356967,11333905,11287575,11265761,11264367,11201791,11086073,11069996,11024154,10875613,10816381,10738970,10600606,10590121,10582593,10559349,10482576,10446313,10430052,10393974,10371171,10364484,10358157,10329539,10074122,9826718,9780207,9770524,9721247,9696823,9658081,9653051,9632631,9614108,9601645,9600268,9499115,9499113,8849450,8805353,8629022" href="/pubmed/25880110,25463598,25231990,25193376,24441862,24312168,24145278,24039179,23804632,23692808,23304142,23211775,23143844,23043104,23043103,22947176,22908191,22783935,22732432,22583677,22470838,22422068,22297516,22237899,22226668,22178016,22163344,22157596,21994672,21994458,21760891,21474836,21310296,21284907,21284899,21152581,20967243,20697919,20051874,20041213,19926478,19692474,19493998,18976462,18833294,18691022,18624812,18500445,18310503,18197116,18032634,17507486,17346946,17292399,17251303,17187670,17144914,17121788,16886061,16886053,16227248,16188969,16174727,16103167,16047221,16046522,15990565,15890935,15784911,15748209,15737612,15585836,15258189,15215692,15113923,15113900,15018709,15014135,14990703,14592831,14576059,12963807,12960231,12953261,12873765,12871111,12864967,12857973,12845769,12832058,12713058,12634405,12614324,12502809,12429730,12429712,12402167,12368322,12163558,12120995,11967288,11931835,11884536,11878912,11877445,11876757,11861874,11799176,11752220,11602639,11504923,11489906,11413305,11397808,11356967,11333905,11287575,11265761,11264367,11201791,11086073,11069996,11024154,10875613,10816381,10738970,10600606,10590121,10582593,10559349,10482576,10446313,10430052,10393974,10371171,10364484,10358157,10329539,10074122,9826718,9780207,9770524,9721247,9696823,9658081,9653051,9632631,9614108,9601645,9600268,9499115,9499113,8849450,8805353,8629022">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Monoclonal antibodies (MAbs) to defined peptide epitopes or N-linked glycans in HIV-1 gp120 inhibit the binding of gp120 to CD4 and exhibit neutralizing activities against HIV-1</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25810537,25803681,25751231,25691567,25504724,25504701,25341782,25339767,25253346,25215485,24990883,24982157,24802758,24767986,24590074,24589930,24554654,24550318,24478429,24409525,24352234,24251545,24243013,24204277,24189188,24179160,24172905,24172896,24172894,24030996,23991039,23878231,23843638,23776539,23757493,23747109,23707685,23692808,23658524,23616655,23539181,23300605,23267106,23237851,23152926,23152508,23115339,23087226,23055568,23023102,22846998,22826297,22807678,22798606,22745174,22623764,22573869,22553332,22419808,22345481,22291921,22284192,22170674,22167180,22113616,22033520,21994452,21938063,21931551,21849977,21760891,21660189,21440555,21357743,21325401,21248038,21226626,21193846,21152581,21037278,20705840,20702629,20616233,20616231,20558728,20463957,20369886,20357769,19965434,18768967,18691028,18638381,18619974,18524826,18377648,18322210,17721546,17413690,17409164,17409160,17360739,17301785,17267498,17263629,17251303,17251298,17239419,17121806,17118792,17090209,17079307,17034868,17006538,16956933,16827663,16817962,16731948,16702010,16616288,16551265,16284180,16160142,16106369,16051303,16035946,15893666,15650196,15572157,15321703,15308718,15279588,15183057,15168796,15090827,15016849,14659896,14585209,14557624,14505925,12768015,12719580,12646921,12646791,12597360,12584309,12502824,12487827,12477867,12208966,12134256,12072528,11734627,11533181,11413337,11413335,10558884,9862697,9739096,9658072,9641677,9264287,9037057,9000083,8995609,8973529,8892926,8827217,8760413,8663408,8627711,8627264,8627160,8615015,8575195,8568275,8551569,8497077,8460995,8455141,8417177,8363802,8331723,8212576,8139010,7935503,7769687,7692037,7690724,7690418,7689324,7687306,7686944,7685405,7615007,7594524,7592573,7562439,7546903,7545244,7544051,7543586,7533854,7529735,7529290,3652531,3497054,3495568,3484980,3466790,3304356,3038935,3027168,3023102,3018753,3006256,2990682,2986291,2986290,2833917,2821115,2482055,2462895,2446880,2441727,2438696,2437327,2436231,2432599,2431482,2431105,2324685,2136376,2068099,1888898,1724568,1722676,1720590,1717717,1710248,1703212,1702163,1690236,1588493,1548744,1543562,1382339,1380099,1376135,1376134,1374095,1370558,1280382,1279195" href="/pubmed/25810537,25803681,25751231,25691567,25504724,25504701,25341782,25339767,25253346,25215485,24990883,24982157,24802758,24767986,24590074,24589930,24554654,24550318,24478429,24409525,24352234,24251545,24243013,24204277,24189188,24179160,24172905,24172896,24172894,24030996,23991039,23878231,23843638,23776539,23757493,23747109,23707685,23692808,23658524,23616655,23539181,23300605,23267106,23237851,23152926,23152508,23115339,23087226,23055568,23023102,22846998,22826297,22807678,22798606,22745174,22623764,22573869,22553332,22419808,22345481,22291921,22284192,22170674,22167180,22113616,22033520,21994452,21938063,21931551,21849977,21760891,21660189,21440555,21357743,21325401,21248038,21226626,21193846,21152581,21037278,20705840,20702629,20616233,20616231,20558728,20463957,20369886,20357769,19965434,18768967,18691028,18638381,18619974,18524826,18377648,18322210,17721546,17413690,17409164,17409160,17360739,17301785,17267498,17263629,17251303,17251298,17239419,17121806,17118792,17090209,17079307,17034868,17006538,16956933,16827663,16817962,16731948,16702010,16616288,16551265,16284180,16160142,16106369,16051303,16035946,15893666,15650196,15572157,15321703,15308718,15279588,15183057,15168796,15090827,15016849,14659896,14585209,14557624,14505925,12768015,12719580,12646921,12646791,12597360,12584309,12502824,12487827,12477867,12208966,12134256,12072528,11734627,11533181,11413337,11413335,10558884,9862697,9739096,9658072,9641677,9264287,9037057,9000083,8995609,8973529,8892926,8827217,8760413,8663408,8627711,8627264,8627160,8615015,8575195,8568275,8551569,8497077,8460995,8455141,8417177,8363802,8331723,8212576,8139010,7935503,7769687,7692037,7690724,7690418,7689324,7687306,7686944,7685405,7615007,7594524,7592573,7562439,7546903,7545244,7544051,7543586,7533854,7529735,7529290,3652531,3497054,3495568,3484980,3466790,3304356,3038935,3027168,3023102,3018753,3006256,2990682,2986291,2986290,2833917,2821115,2482055,2462895,2446880,2441727,2438696,2437327,2436231,2432599,2431482,2431105,2324685,2136376,2068099,1888898,1724568,1722676,1720590,1717717,1710248,1703212,1702163,1690236,1588493,1548744,1543562,1382339,1380099,1376135,1376134,1374095,1370558,1280382,1279195">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Divergent HIV-1 strains differ in their stoichiometry of entry and require between 1 to 7 HIV-1 gp120/gp41 trimers, with most strains depending on 2 to 3 trimers to complete entry through the interaction with CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25569556" href="/pubmed/25569556">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Two independent mutations in HIV-1 subtype A gp120, G312V (V3 loop) and A204E (C2 region), are identified to gain increased affinity to soluble CD4 compared to the wild-type</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25378497,21325401" href="/pubmed/25378497,21325401">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Some synthetic peptides as agonists of the HIV-1 envelope glycoprotein gp120 or CD4 receptor block the binding of gp120 and CD4; other peptides do not block the binding between gp120 and CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25639621,24502450,24390333,24304511,23931277,23692808,23300605,23209523,23176398,22559037,22551420,22524483,22083481,21152581,20186035,19553524,17320923,16736946,16611063,15665647,11413337,11311058,10557278,8977179,8827218,8811198,8649438,8615021,8460995,8419649,8356059,8102473,7831801,7737288,7692087,7616571,7494500,3682024,2062847,1931230,1717587,1711118,1592430,1551875,1489581,1382339,1376134,1354808,1354681,1352879" href="/pubmed/25639621,24502450,24390333,24304511,23931277,23692808,23300605,23209523,23176398,22559037,22551420,22524483,22083481,21152581,20186035,19553524,17320923,16736946,16611063,15665647,11413337,11311058,10557278,8977179,8827218,8811198,8649438,8615021,8460995,8419649,8356059,8102473,7831801,7737288,7692087,7616571,7494500,3682024,2062847,1931230,1717587,1711118,1592430,1551875,1489581,1382339,1376134,1354808,1354681,1352879">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Using single-molecule fluorescence resonance energy transfer within the context of native gp120 trimers on the surface of HIV-1 virions, indicates a significant conformational change between unliganded and CD4-binding trimers</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25298114" href="/pubmed/25298114">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">SMS2, but not SMS1, is involved in enhancement of HIV-1 gp120/gp41-mediated membrane fusion through CD4 receptor and CCR5/CXCR4 coreceptors</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25231990" href="/pubmed/25231990">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CD4 binding to HIV-1 gp120/gp41 trimers results in significant conformational changes in M150 and M161 in gp120 V1/V2 and F316 in gp120 V3, but causes little changes in M104, M95, and the triad of gp41 leucines</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25007222,24931470" href="/pubmed/25007222,24931470">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CCR5 expression inhibits HIV-1 gp120-induced LIMK1 activation and cofilin phosphorylation in CD4/CXCR4 expressing 293T cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24778234" href="/pubmed/24778234">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CCR5 expression inhibits HIV-1 gp120 binding to CD4/CXCR4 complexes in 293T cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24778234" href="/pubmed/24778234">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CCR5 expression inhibits HIV-1 gp120-mediated early actin rearrangement in CD4/CXCR4 expressing 293T cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24778234" href="/pubmed/24778234">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120-enhanced CD4/CXCR4 conformation changes are regulated by CCR5 expression in 293T cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24778234" href="/pubmed/24778234">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The net charge of HIV-1 gp120 V3 loop influences the global structure and diversity of the interaction surface of the gp120 outer domain to CD4 binding and epitopes exposure</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25313689,24134524,23840566,22624045" href="/pubmed/25313689,24134524,23840566,22624045">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 interacts with CD4 and alpha5beta3 in peripheral blood monocyte-derived macrophages; neutralizing antibodies against the alpha5beta3 integrin interfere with the coprecipitation of alpha5beta3 with an anti-gp120 antibody</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 12083833" href="/pubmed/12083833">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CD4 binding residues T257, E370, S375, N425, G429, and G473 of HIV-1 gp120 are involved in NBD analogues interaction with gp120</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24489681" href="/pubmed/24489681">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The Cryo-EM structure shows that localization at the gp120-gp41 interface allows the fusion peptide region to be released in response to CD4 and co-receptor-induced conformational changes within gp120 and gp41 that drive membrane fusion</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24179160,24179159" href="/pubmed/24179160,24179159">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 is incapable of binding a fully oxidized, monomeric 2dCD4 in which both domain 1 and 2 disulfides are intact, but binds to reduced counterparts that are the ostensible products of Trx-mediated isomerization</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24550395" href="/pubmed/24550395">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Deletion of both HIV-1 nef and vpu genes enhance a significant engagement between HIV-1 gp120 and CD4 at the cell surface, suggesting Nef and Vpu prevent the exposure of epitopes recognized by anti-gp120 antibody-dependent cell-mediated cytotoxicity</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24498878,24352444" href="/pubmed/24498878,24352444">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 is sulfated at positions Y173 and Y177 in the V2 domain by tyrosyl sulfotransferase 2 (TPST2), leading to modulate gp120 epitope exposure and neutralization sensitivity to soluble CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24569807" href="/pubmed/24569807">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The ability of thioredoxin, a protein disulfide isomerase (PDI), to reduce the disulfide bond in CD4 is enhanced in the presence of HIV-1 gp120</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24550395,16507315" href="/pubmed/24550395,16507315">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Small molecules exhibit strong anti-HIV-1 activity by binding specifically to both HIV-1 gp120 and/or cell surface receptors (CD4, CCR5, CXCR4) and prevent gp120/CD4/CCR5 and gp120/CD4/CXCR4 complex formation and cell-cell fusion</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24614386,24039179,23931277,23862963,23692808,23541872,23308369,23278399,23153179,21193846,21152581,20162270,19000821,18624812,17825297,17676933,17328229,17251303,16515489,16309726,16185162,16103167,16002156,15996703,15956589,15857997,15807900,15778371,15729334,15577644,15321703,15258189,15194768,15180541,15180540,15113923,15109676,15051887,15016894,14967033,12970437,12930892,12769725,8948487,8605026" href="/pubmed/24614386,24039179,23931277,23862963,23692808,23541872,23308369,23278399,23153179,21193846,21152581,20162270,19000821,18624812,17825297,17676933,17328229,17251303,16515489,16309726,16185162,16103167,16002156,15996703,15956589,15857997,15807900,15778371,15729334,15577644,15321703,15258189,15194768,15180541,15180540,15113923,15109676,15051887,15016894,14967033,12970437,12930892,12769725,8948487,8605026">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The interaction between exposed cyclophilin A (CypA) and cell surface heparans represents the initial step of HIV-1 attachment and is a necessary step for HIV-1 gp120 binding to CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24312095,10581250" href="/pubmed/24312095,10581250">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Antibodies to specific epitopes of the CCR5 or CXCR4 chemokine receptors inhibit the entry of M-tropic, T-tropic, or dual-tropic HIV-1 into target cells by blocking the interaction of the receptors with the HIV-1 gp120/CD4 complex</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24696475,23692808,21994672,21351734,20166763,17507486,11327825,11069996" href="/pubmed/24696475,23692808,21994672,21351734,20166763,17507486,11327825,11069996">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Protein-disulfide isomerase (PDI) cleaves disulfide bonds in recombinant HIV-1 envelope glycoprotein gp120, and gp120 bound to the surface receptor CD4 undergoes a disulfide reduction that is prevented by PDI inhibitors</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24550395,14592831,12218052,12218051" href="/pubmed/24550395,14592831,12218052,12218051">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Binding of recombinant soluble CD4 (sCD4), the purified V1 domain of sCD4, or neutralizing antibodies to the HIV-1 surface glycoprotein gp120 on virions results in rapid dissociation of gp120 from its complex with the transmembrane glycoprotein gp41</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24146829,23757493,23658524,23267106,23237851,23152926,21715496,12719560,8906988,8627160,8437224,7904656,7904348,7693970,7678271,7515973,2251501,2006155,1995942,1896455" href="/pubmed/24146829,23757493,23658524,23267106,23237851,23152926,21715496,12719560,8906988,8627160,8437224,7904656,7904348,7693970,7678271,7515973,2251501,2006155,1995942,1896455">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">A high affinity interaction between the HIV-1 glycoprotein gp120/gp41 complex and the cellular receptor CD4 is necessary for both virus-cell and cell-cell fusion; the V3 region (amino acids 301-336) of gp120 and gp41 amino terminus are involved in fusion</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24583235,18837996,17084877,12885233,12406507,9349472,8892926,8891109,8806567,8726523,8560767,8551601,8510207,8437234,8361381,8331723,8280475,8160267,8129620,7897356,7754236,7737288,7707502,7688827,7618285,7592573,6096719,3257102,3095663,3016552,3001934,2995487,2830667,2374593,2109100,1995942,1985197,1910691,1899141,1870202,1845049,1742075,1721822,1720627,1709701,1706342,1636088,1627247,1622897,1602552,1548769,1548744,1546447,1527858,1501286,1457207,1380099,1376135,1370739,1370558,1348943,1281202" href="/pubmed/24583235,18837996,17084877,12885233,12406507,9349472,8892926,8891109,8806567,8726523,8560767,8551601,8510207,8437234,8361381,8331723,8280475,8160267,8129620,7897356,7754236,7737288,7707502,7688827,7618285,7592573,6096719,3257102,3095663,3016552,3001934,2995487,2830667,2374593,2109100,1995942,1985197,1910691,1899141,1870202,1845049,1742075,1721822,1720627,1709701,1706342,1636088,1627247,1622897,1602552,1548769,1548744,1546447,1527858,1501286,1457207,1380099,1376135,1370739,1370558,1348943,1281202">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 induces the dissociation of p56lck from CD4 and the downregulation of CD4 from the cellular surface</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24352444,22291690,20380698,16886061,16873261,10941932,9621091,9473011,8862276,7821926,7774645,7545243,2040625,1622897,1535086,1491632" href="/pubmed/24352444,22291690,20380698,16886061,16873261,10941932,9621091,9473011,8862276,7821926,7774645,7545243,2040625,1622897,1535086,1491632">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The layer 3 residues (amino acids 247-254 and 476-483) of HIV-1 gp120 are located in the beta8 strand and alpha5 helix of the CD4-bound gp120. The five layer 3 mutants T248A, H249A, R476A, N478A, and W479A exhibit decreased CD4-binding activity</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23255784" href="/pubmed/23255784">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Gelsolin overexpression impairs HIV-1 gp120-induced cortical F-actin reorganization and capping and gp120-mediated CD4-CCR5 and CD4-CXCR4 redistribution in permissive lymphocytes</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23575248" href="/pubmed/23575248">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 binds and signals through CD4, which leads to T cell activation with upregulation of the CXCR5, PD-1, Fas, and FasL expression</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23742646" href="/pubmed/23742646">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CD4-mediated endocytosis of HIV-1 gp120 results in MHC-II (HLA-DR) presentation to CD4+ T cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23729440" href="/pubmed/23729440">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Immature HIV-1 virions are competent for CD4-induced gp120 conformational changes</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21931551" href="/pubmed/21931551">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120-mediated inhibition of IFN-alpha production involves CD4 and BDCA2 in plasmacytoid dendritic cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23100517" href="/pubmed/23100517">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CD4 binding shifts the V1/V2 regions of HIV-1 gp120 to unmask the co-receptor binding site, and triggers profound dynamic changes in gp120 spanning from the binding site to the gp41-interactive face of gp120</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22674993" href="/pubmed/22674993">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Brain-derived HIV-1 Env gp120 proteins efficiently use very low levels of CD4 to enter cells, whereas lymph-node-derived gp120 proteins are dependent on higher levels of CD4 to enter cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23077246" href="/pubmed/23077246">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">N425K mutation of HIV-1 gp120 impacts CD4 interactions and confers HIV-1 resistance to maraviroc (MVC)</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23135713" href="/pubmed/23135713">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Small molecule BMS-488043 inhibits the interaction of HIV-1 gp120 with CD4 by blocking the rotation of the Trp112 located on the alpha1 helix of gp120</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23086459,21465559" href="/pubmed/23086459,21465559">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CD4-linker-DC-SIGN fusion proteins enhance binding affinity to HIV-1 gp140 and gp120 in comparison to sCD4 and sDC-SIGN. These fusion proteins inhibit HIV-1 capture and transfer via DC-SIGN-expressing cells and iMDDCs</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22687513" href="/pubmed/22687513">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 induces an elongated phenotype in infected CD4+ T cells. These HIV-infected T cells tether to other lymph node CD4+ cells and form syncytia through gp120/gp41, and migrate to distant tissues to disseminate</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22854780" href="/pubmed/22854780">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The N260Q gp120 mutant has a significantly lower binding to the recombinant soluble CD4 in comparison with wild-type</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22006924" href="/pubmed/22006924">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Human alpha-defensin-5 binds to both HIV-1 gp120 and CD4 and blocks the interaction of CD4 with gp120, which leads to inhibit HIV-1 replication in human primary CD4+ T lymphocytes</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24086683,23028850" href="/pubmed/24086683,23028850">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Feglymycin, a natural Streptomyces-derived 13mer peptide, inhibits HIV-1 gp120 binding to CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22959895" href="/pubmed/22959895">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">A single Y681H substitution in HIV-1 gp41 increases the gp120-CD4 binding and enhances infectivity in low CD4 expressing cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22606344" href="/pubmed/22606344">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Individual gp120-CD4 bonds undergo rapid destabilization and this destabilization is significantly enhanced by the coreceptor CCR5, not by CXCR4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 18480458" href="/pubmed/18480458">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Association and clustering of CD4-CXCR4 induced by HIV-1 gp120 requires moesin-mediated anchoring of actin in the plasma membrane</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 19066282" href="/pubmed/19066282">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Interaction of the X4-tropic protein HIV-1 gp120 with CD4 augments ezrin and moesin phosphorylation in human permissive T cells, thereby regulating ezrin-moesin activation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 19066282" href="/pubmed/19066282">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 isolated from southern African HIV type 1 subtype C exhibits high-affinity binding to CD4 and the Cys228-Cys239 disulfide bond of gp120 is required for the high-affinity binding to CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 19018669" href="/pubmed/19018669">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Antibodies to LFA-3 block the early stages of HIV-1 infection by cell-free virus following HIV-1 gp120 binding to CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 1757107" href="/pubmed/1757107">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The binding of HIV-1 gp120 to CD4 molecules on T cells interrupts the sequential cascade of intercellular interactions involving antigen/MHC class II-TCR/CD4, CD40L-CD40, and B71-CD28</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 7541827" href="/pubmed/7541827">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Alpha-defensins inhibit the binding of HIV-1 gp120 to CD4 through interaction with the D1 domain of CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 17132727" href="/pubmed/17132727">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The V3 domain of HIV-1 gp120 induces associations between CD4 and CCR5 receptors in cholesterol-rich microenvironments</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 16963439" href="/pubmed/16963439">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Binding gp140 to the synthetic CD4-mimicking mini protein leads to an outward domain shift of the three gp120 subunits, which diminishes gp120-gp41 interactions</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21444771" href="/pubmed/21444771">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">D279 in the C2 region and N362 in the C3 region of HIV-1 gp120 augment the gp120-CD4 interaction</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21216423" href="/pubmed/21216423">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 drastically reduces the ratio of CD4 dimers/monomers</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20739067" href="/pubmed/20739067">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Maleic anhydride-modified ovalbumin inhibits HIV-1 entry by targeting both gp120 on HIV-1 virions and CD4 receptor on the host cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20420669" href="/pubmed/20420669">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Palmitic acid analog 2-bromopalmitate (2-BP) efficiently binds to CD4 leading to the inhibition of gp120-to-CD4 binding</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20730055" href="/pubmed/20730055">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 interacts with CD4 to cause apoptosis in human mesenchymal stem cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21612582" href="/pubmed/21612582">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">A fusion of the CD4- and CCR5-mimetic peptides, DM1, binds gp120 and neutralizes R5, R5X4, and X4 HIV-1 isolates comparably to CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21613393" href="/pubmed/21613393">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Griffithsin (GRFT) interaction with gp120 exposes the CD4 binding site by binding the glycan at position 386</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21697467" href="/pubmed/21697467">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Sphingomyelinase inhibits viral fusion after the engagement of HIV-1 gp120 with CD4 and this inhibition is dependent on CD4 expression levels</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 17344303" href="/pubmed/17344303">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Tick salivary protein Salp15 prevents gp120-CD4 interaction at least partially through its direct interaction with the envelope glycoprotein in the C1 domain of gp120</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 18162176,18045872,17082567" href="/pubmed/18162176,18045872,17082567">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Competition assays with CD4 and mAbs suggest that SP-A inhibits infectivity by occlusion of the CD4-binding site on gp120</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 18566427" href="/pubmed/18566427">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">In resting CD4 T cells, only the HIV envelope-mediated entry, but not the VSV-G-mediated endocytosis, can lead to viral DNA synthesis and nuclear migration</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 19851458" href="/pubmed/19851458">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">In a CD4-bound state, gp120 elements proximal to the gp41 interface complete a 7-stranded beta-sandwich, which appeared invariant in conformation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20080564" href="/pubmed/20080564">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Co-expression of CD4 and DC-SIGN in Raji cells promotes internalization and intracellular retention of HIV-1 through interaction with HIV-1 gp120</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 17151103" href="/pubmed/17151103">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Expression of CD4 on Raji B cells strongly inhibits DC-SIGN-mediated HIV-1 transmission to T cells, presumably through interaction with HIV-1 gp120</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 17151103" href="/pubmed/17151103">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CCR5- or CXCR4-tropic HIV-1 induce Indoleamine 2,3-dioxygenase (IDO) in plasmacytoid dendritic cells and this induction is inhibited by the blockade of gp120/CD4 interactions with antibodies to CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 17158233" href="/pubmed/17158233">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Substitution of highly conserved isoleucine with methionine at position 424 in the C4 domain of gp120 confers enhanced neutralization sensitivity to plasma antibodies and increases its interaction with sCD4 but not with CCR5</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21851958" href="/pubmed/21851958">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 infections originating from cell-free virus by CD4/gp120 interactions decrease strongly in the presence of antiretrovirals tenofovir and efavirenz whereas infections involving cell-to-cell spread are markedly less sensitive to the drugs</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21886150,21849975" href="/pubmed/21886150,21849975">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Bile salt-stimulated lipase (BSSL), a Lewis X (LeX)-containing glycoprotein found in human milk, binds to DC-SIGN and inhibits the interaction of gp120 with CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 17005819" href="/pubmed/17005819">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The disulfide cross-linking interaction between gp120 and PDI is enhanced by CD4 protein</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20943653,20458450" href="/pubmed/20943653,20458450">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Focal adhesion kinase (FAK), CD4, and HIV-1 gp120 co-localize in T cells. The formation of FAK-CD4 complex is induced by gp120</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 18078954" href="/pubmed/18078954">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Epigallocatechin gallate (EGCG) purified from the green tea catechin inhibits attachment of HIV-1 glycoprotein 120 to the CD4 molecule on T cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 19103208,17157668" href="/pubmed/19103208,17157668">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">H66N change in gp120 stabilizes the HIV-1 envelope glycoprotein complex once the CD4-bound state is achieved and decreases the probability of CD4-induced inactivation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 19535453" href="/pubmed/19535453">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Two potentially flexible topological layers (layers 1 and 2) in the gp120 inner domain (layer 1-layer 2) interactions strengthen gp120-CD4 binding by reducing the off rate when CD4 makes initial contact with the gp120 outer domain</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20227370" href="/pubmed/20227370">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120-induced Ca(2+) fluxing is CD4 dependent and coreceptor specific, and is mediated by the CCR5 and CXCR4 coreceptors</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 17121788" href="/pubmed/17121788">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Virions carrying both HIV-1 R5 env and VSV-G can fuse to naive CD4+ T cells because CD4 binding allows viral uptake</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20980513" href="/pubmed/20980513">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Genistein, tyrosine kinase inhibitor, inhibits cell fusion between macrophages and HIV-1 Env expressing cells. Genistein treatment does not change CD4 or CCR5 surface expression and has no effect on gp120-CD4-CCR5 complex formation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 17030448" href="/pubmed/17030448">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Studies by sequential (SAP) and competitive (CAP) antigen panning methodologies show that some antibodies bind better to gp120-CD4 complexes than to gp120 alone</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 17269928" href="/pubmed/17269928">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The ability of gp120 to inhibit SDF-1alpha-induced chemotaxis is mediated by the CD4 receptor and Lck signaling</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20835359" href="/pubmed/20835359">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Subtype C gp120 isolates carrying I309L enhance utilization of CD4 but do not affect the ability to use CCR5</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20494390" href="/pubmed/20494390">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Virological synapse-mediated cell-to-cell HIV-1 transfer is dependent upon gp120/gp41 and CD4 interactions and is more efficient than that of a cell-free mode of uptake, yet the presence of the full CD4 cytoplasmic tail is not essential for the process</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24157907,24029736,24005480,22908191,21284901,18632854,17728240" href="/pubmed/24157907,24029736,24005480,22908191,21284901,18632854,17728240">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Siva-1 sensitizes CD4-positive T-cells to HIV-1 gp120/gp41-induced apoptosis. The Siva-1-mediated sensitization on CD4-positive T-cells shows significant activation of caspase-3, -8, and -9</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 17653867" href="/pubmed/17653867">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The V1-V3 region of a brain-derived HIV envelope glycoprotein plays a crucial role in determining the virus' low CD4 dependence and increased macrophage tropism, as well as its augmented fusogenicity and reduced sensitivity to the inhibitor BMS-378806</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 18837996" href="/pubmed/18837996">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 hydrogen bond interactions among transmembrane residues Y108, E283, and Y251, are crucial for HIV-1-gp120/sCD4 complex binding and HIV-1 fusion. HIV-1 gp120 binding to CCR5 disrupts these interhelix hydrogen bond interactions</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 18590744" href="/pubmed/18590744">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Deletion of the HIV-1 gp120 major variable regions (V1/V2/V3) stabilizes gp120 core proteins into the conformation recognized by CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 19478876" href="/pubmed/19478876">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">A synthetic CD4-mimetic peptide conjugating with a heparan sulfate dodecasaccharide binds to gp120 and induces the exposure of the coreceptor binding domain available for interaction with the oligosaccharide</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 19734912" href="/pubmed/19734912">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 promotes filamin binding to both CD4 and CXCR4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 19366992" href="/pubmed/19366992">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CIITA-mediated enhancement of HIV-1 infection is gp120/gp41/CD4-dependent and occurs at the early steps in the infection cycle</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21041720" href="/pubmed/21041720">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Elimination of the CD4 domain 2 disulfide bond (Cys130-Cys159) by mutation enhances HIV-1 gp120/gp41-mediated cell-cell fusion and virus entry</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20974843" href="/pubmed/20974843">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Thioredoxin cleaves the gp120 disulfide bond (Cys296-Cys331) in the V3 domain and the cleavage is enhanced by CD4-expressing cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20943653" href="/pubmed/20943653">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The cis expression of DC-SIGN on multiple lymphoid cell lines enables more efficient entry and replication of CXCR4-tropic and CCR5/CXCR4 dual-tropic HIV-1 through its binding to the HIV-1 gp120-CD4-CXCR4 complex</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 11711593" href="/pubmed/11711593">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 specifically recognizes the C-terminal heparin-binding domain of fibronectin (Fn) and this binding inhibits the interaction of gp120 with soluble CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 9443108" href="/pubmed/9443108">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Apoptosis of CD4+ lymphocytes induced by HIV-1 gp120 cross-linking to CD4 is inhibited by IL-12</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 7867080,7821926" href="/pubmed/7867080,7821926">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22433250,8801439,2851650,1979339,1310988" href="/pubmed/22433250,8801439,2851650,1979339,1310988">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Galectin-1, a dimeric beta-galactoside-binding protein, promotes infection with CCR5-tropic, CXCR4-tropic, and CCR5/CXCR4 dual-tropic HIV-1 variants by facilitating attachment of HIV-1 gp120 to CD4 at the cell surface</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21880749,15778371" href="/pubmed/21880749,15778371">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The binding of HIV-1 gp120 to CD4+-permissive cells increases the level of acetylated alpha-tubulin in a CD4-dependent manner; overexpression of Histone Deacetylase 6 (HDAC6) inhibits the acetylation of alpha-tubulin and prevents HIV-1-cell fusion</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 16148047" href="/pubmed/16148047">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Griffithsin isolated from an aqueous extract of the red alga Griffithsia species blocks CD4-dependent HIV-1 gp120 binding to receptor-expressing cells and binds to viral coat glycoproteins (gp120, gp41, and gp160) in a glycosylation-dependent manner</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 15613479,15572157" href="/pubmed/15613479,15572157">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120-CD4 interaction is necessary to repress HIV-1 long terminal repeat-dependent luciferase activity; the cytoplasmic domain of CD4 is found to be required for this effect to occur</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 8648738" href="/pubmed/8648738">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Binding of HIV-1 gp120 to CD4 molecules in cells results in the association of Lck and Raf-1, which is abolished by preincubation of the virus with soluble CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 8887682" href="/pubmed/8887682">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The fusion of insulin-like growth factor I (IGF I) with stromal cell-derived factor I or alpha1 proteinase inhibitor has the capacity to compete with the binding of HIV-1 gp120 to CD4 receptor</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 12787886" href="/pubmed/12787886">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Phorbol myristate acetate (PMA) pretreatment of CD4+ cells prevents subsequent HIV-1 gp120-induced downregulation of CD4 receptor molecules</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 7906314,1970444" href="/pubmed/7906314,1970444">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Expression of the HIV-1 envelope gene in CD4+ T cell lines and binding of HIV-1 gp120 to CD4 is sufficient for the induction of apoptosis</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 11397808,8891109,8806567,8738430,8105835,7906657,7897356,7897355,7589092,7589091" href="/pubmed/11397808,8891109,8806567,8738430,8105835,7906657,7897356,7897355,7589092,7589091">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Combinations of CD4-based molecules and antibodies to HIV-1 gp120 and/or gp41 inhibit cell fusion formation mediated by the interaction of CD4 to gp120</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 8369162" href="/pubmed/8369162">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Following incubation with a soluble form of CD4, gp120 of highly purified HIV-1 preparations is cleaved without addition of exogenous proteinase, yielding two proteins of 50 and 70 kDa; this cleavage likely occurs in the gp120 V3 loop</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 8474162" href="/pubmed/8474162">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Mutants with amino acid changes in the V1/V2 region (residues 131-196) of the HIV-1 gp120 are able to bind CD4 but are deficient in syncytium formation and/or virus entry</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20874088,18837996,8497077,8331723" href="/pubmed/20874088,18837996,8497077,8331723">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Release of neurotoxins from monocytes through HIV-1 gp120 stimulation involves CD4 receptors; toxin production can be inhibited either by a monoclonal antibody to the CD4-binding region of gp120 or by soluble CD4 receptors</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 8464887" href="/pubmed/8464887">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Calcium ions are required for cell fusion mediated by interactions between CD4 and HIV-1 gp120/gp41; EDTA and EGTA block cell fusion in culture media containing calcium ions</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 10758170,8437234,7874384,7774645" href="/pubmed/10758170,8437234,7874384,7774645">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The third complementarity-determining region (CDR3; residues 79-96) within domain 1 of the human CD4 molecule plays a critical role in membrane fusion mediated by the interaction of CD4 with HIV-1 gp120</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 8419649" href="/pubmed/8419649">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Binding of HIV-1 gp120 to the CD4 receptor molecule results in co-stimulation of CD3-induced T cell activation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 9344703,9043947,8125527,7914230,7774645,7506554" href="/pubmed/9344703,9043947,8125527,7914230,7774645,7506554">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120-mediated CD4 engagement is involved in the induction of susceptibility of primary human T lymphocytes to CD95-mediated apoptosis through ezrin phosphorylation and ezrin-to-CD95 association</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 15719026,14739941" href="/pubmed/15719026,14739941">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The chemokine receptor CCR5 is posttranslationally modified by sulfation of its N-terminal tyrosines; sulfated tyrosines contribute to the binding of CCR5 to MIP-1 alpha, MIP-1 beta, and HIV-1 gp120/CD4 complexes and to the ability of HIV-1 to enter cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 10089882" href="/pubmed/10089882">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The inhibition of IL-2R expression and proliferation induced by the interaction of CD4 with HIV-1 envelope glycoprotein gp120 is correlated with the inhibition of expression and activation of Janus kinase JAK3</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 9637477" href="/pubmed/9637477">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Antibodies to specific epitopes of HIV-1 gp120 block the interaction of CCR5 with the gp120/CD4 complex, suggesting that a CD4-mediated conformational change in gp120 is required for subsequent binding to CCR5</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23692808,22547820,22291921,21994672,21760891,21351734,21325401,18833294,17239419,17053352,16817962,16796521,16777164,16702010,15857992,12887918,11333905,9334377,9261346" href="/pubmed/23692808,22547820,22291921,21994672,21760891,21351734,21325401,18833294,17239419,17053352,16817962,16796521,16777164,16702010,15857992,12887918,11333905,9334377,9261346">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">A specific interaction between CD4 and HIV-1 gp120 is required for phosphorylation of CD4, which could involve protein kinase C</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 3259291" href="/pubmed/3259291">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Amino acid residues 42-49 and 54-57 in the V1 region of CD4 are involved in the interaction of CD4 with both HIV-1 gp120 and class II major histocompatibility complex molecules</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 12033937,1978941,1967269,1889086,1888898,1713692,1465431" href="/pubmed/12033937,1978941,1967269,1889086,1888898,1713692,1465431">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Mutations at four locations (amino acids 29, 59-64, 77-81, and 85) outside the antigen-complementarity-determining region (CDR2)-like sequence of CD4 markedly affect HIV-1 gp120 binding</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23209523,2402498" href="/pubmed/23209523,2402498">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Removal of the N-linked sugars on HIV-1 gp120 by endoglycosidase H treatment results in deglycosylated proteins that are unable to bind to CD4, suggesting that glycosylation contributes to the ability of gp120 to bind to CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23087226,15183057,8627264,8416385,8160267,8122371,2536098,2136376,2111957,2076345,1698804,1549584,1493050,1370558" href="/pubmed/23087226,15183057,8627264,8416385,8160267,8122371,2536098,2136376,2111957,2076345,1698804,1549584,1493050,1370558">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Deletion analysis shows that amino acid regions 82-95, 386-389, 424-432, and 487-499 constitute a part of the HIV-1 gp120 binding region to CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 2550679" href="/pubmed/2550679">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120/160 deglycosylated by Endo H and Endo F still binds to CD4, indicating that the carbohydrates of gp120/160 do not play a significant role in the in vitro binding to CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 12438611,8438588,8419650,8160267,8129620,7832633,2538547,2335819" href="/pubmed/12438611,8438588,8419650,8160267,8129620,7832633,2538547,2335819">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 suppresses T and B cell activation and the expression of cytolytic activities through its interaction with CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 16829607,10623764,10202115,9637477,9604776,9548463,9344703,9269777,9123823,9043947,9036944,9002959,8801439,8575195,8552983,7913036,7615007,7589092,2468713,1388715,1356673" href="/pubmed/16829607,10623764,10202115,9637477,9604776,9548463,9344703,9269777,9123823,9043947,9036944,9002959,8801439,8575195,8552983,7913036,7615007,7589092,2468713,1388715,1356673">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 and class II MHC binding sites of CD4 are distinct and can be separated</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 11535811,8075984,2555159,2549633,1889086,1711033" href="/pubmed/11535811,8075984,2555159,2549633,1889086,1711033">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">A single amino-acid change (cysteine 402 or tryptophan 432) in HIV-1 gp120 can abrogate CD4 binding</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 2475780,2045792" href="/pubmed/2475780,2045792">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Apoptosis induced by HIV-1 gp120/CD4 cross-linking in Th1 clones is inhibited by anti-CD95 or anti-CD95L neutralizing monoclonal antibodies, as well as by a specific interleukin-1 beta converting enzyme (ICE) inhibitor</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 15719026,10505674,9548463,9226175,9002959" href="/pubmed/15719026,10505674,9548463,9226175,9002959">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">IL-16 induces rapid translocation of PKC from the cytosol to the membrane in CD4+ cells; PKC inhibitors completely block IL-16-induced lymphocyte migration as well as the motile response induced by HIV-1 gp120 and anti-CD4 antibody binding to CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 8599832" href="/pubmed/8599832">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CD4 downregulation by the treatment of macrophages with HIV-1 gp120 is mediated through the induction of endogenous TNF-alpha</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 11290759,8707350" href="/pubmed/11290759,8707350">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">A CD4 peptide (amino acids 74-95) inhibits the binding of gp120 to CD4+ human lymphoblastic leukemia (CEM) cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 1971526,1931230,1551875" href="/pubmed/1971526,1931230,1551875">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Through binding to cell surface CD4, both HIV-1 gp120 and gp160 inhibit syncytia formation between HIV-1-infected cells and CD4+ cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 2187500,1977427,1910691,1721822" href="/pubmed/2187500,1977427,1910691,1721822">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Chimpanzee CD4 molecules bearing the human amino acid at position 87 support syncytium formation, while human CD4 molecules bearing the chimpanzee residue at position 87 do not; HIV-1 gp120 binding to CD4 is not affected by the substitution at position 87</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 2107024" href="/pubmed/2107024">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Expression of a soluble CD4 mutant molecule lacking transmembrane and cytoplasmic domains blocks secretion of HIV-1 gp120 and surface expression of HIV-1 gp120 and gp41 from the endoplasmic reticulum</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 2190096,1374095" href="/pubmed/2190096,1374095">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Small molecules, termed N-carbomethoxycarbonyl-prolyl-phenylalanyl benzyl esters (CPFs), block the binding of gp120 to CD4, but do not interfere with the binding of CD4 to class II major histocompatibility complex molecules</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 2115689" href="/pubmed/2115689">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 with substitution of cysteine's 296, 331, 418 or 445 on fails to bind to CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 2182910" href="/pubmed/2182910">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The N-terminal region of HIV-1 gp120 contains conserved residues (amino acids 56-62 and 108-116) critical for binding to CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22696649,21465559,18590744,2339113,1910691,1721822" href="/pubmed/22696649,21465559,18590744,2339113,1910691,1721822">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Changes in two hydrophobic regions (Thr-257 and Trp-427) and two hydrophilic regions (Asp-368, Glu-370, and Asp-457) of HIV-1 gp120 result in significant reductions in CD4 binding</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22497421,2243375,1567578" href="/pubmed/22497421,2243375,1567578">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Expression of the human CD4 receptor in murine T-cells is sufficient for syncytia formation with HIV-1 envelope expressing cells and entry of MLV/HIV pseudotyped retroviral vectors, suggesting that the murine CXCR4 is a functional coreceptor</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 12191776" href="/pubmed/12191776">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CD4(+)CD45RO(+) cells display high HIV-1 gp120-binding capacity, whereas CD4(+)CD45RO(-) cells show undetectable HIV-1 gp120 binding</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21284901,11804554" href="/pubmed/21284901,11804554">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The physiological levels of cell-surface CD4 interfere with HIV-1 replication in T cells by a mechanism that inhibits HIV-1 gp120 envelope incorporation into viral membranes</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 12008044,11704677" href="/pubmed/12008044,11704677">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Syncytial apoptosis mediated by the fusion of cells expressing HIV-1 gp120 with cells expressing the CD4/CXCR4 receptor/coreceptor complex causes phosphorylation of p53 on serine 15 and Bax upregulation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 15719026,11602639" href="/pubmed/15719026,11602639">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Mutation of two basic amino acids Lys46 and Arg59 in CD4 dramatically disrupts its ability to bind HIV-1 gp120</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22497421,1732513" href="/pubmed/22497421,1732513">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CD4-expressing human T cell lines induce significant and rapid conformational changes in gp120-gp41 from T cell-tropic HIV-1 strains, and little conformational changes in gp120-gp41 from macrophage-tropic HIV-1 strains</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 9573233,9417096" href="/pubmed/9573233,9417096">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Binding of HIV-1 gp120 to CD4 receptor induces p56lck activation and zeta-chain (TCR) associated protein kinase 70kDa desensitization independent of TCR tyrosine phosphorylation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22433250,9123823,9036944,7522245" href="/pubmed/22433250,9123823,9036944,7522245">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Pretreatment of HIV-1 infected cells with TNF alpha augments syncytia formation mediated by the interaction of HIV-1 gp120 with cell surface CD4 molecules</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 15936090,1380260" href="/pubmed/15936090,1380260">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Interaction of HIV-1 gp120 with cell-associated CD4 leads to the induction of IFN alpha; preincubation of cells with anti-CD4 or the presence of soluble CD4 during incubation inhibits IFN alpha induction</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 18579609,15936090,1381203" href="/pubmed/18579609,15936090,1381203">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Cleavage at position R315 of HIV-1 gp120 by thrombin is enhanced by soluble CD4 binding</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 2015114" href="/pubmed/2015114">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Two disulfide bonds linking cysteine residues at positions 378 and 445 and positions 385 and 418 in the carboxyl terminus of HIV-1 gp120 contribute to CD4 binding</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 1738091" href="/pubmed/1738091">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Amino acid residues (102-126) and (425-452) of HIV-1 gp120 contribute to the binding site for CD4 and are expected to be juxtaposed in the folded gp120 chain</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22696649,12885233,1373549" href="/pubmed/22696649,12885233,1373549">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Crosslinking of HIV-1 gp120 on human CD4+ T cells followed by signaling through the TCR results in activation-induced apoptosis</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 16829607,9604776,9344703,8801439,8547064,7913036,7754236,7589091,1402655" href="/pubmed/16829607,9604776,9344703,8801439,8547064,7913036,7754236,7589091,1402655">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">LFA-1 adhesion molecules are not involved in the early stages of cell membrane fusion mediated by the interaction of gp120 with CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 1457205" href="/pubmed/1457205">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Down modulation of the interaction between HIV-1 gp120 and CD4 by TPA is blocked by protein kinase C (PKC) inhibitors, suggesting PKC may play an important role in HIV-1 infection</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 1970444" href="/pubmed/1970444">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">12-O-tetradecanoylphorbol-13-acetate (TPA) down-modulates the expression of CD4, which is essential for syncytia formation through interaction with the HIV-1 envelope protein gp120</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 1970444" href="/pubmed/1970444">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Glycolipids such as galactosylceramides, sulfogalactoceramides, globotriosylceramide, and gangliosides play an important role as HIV-1 fusion cofactors following the interaction of CD4 and HIV-1 gp120</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 17234232,11201791,11070895,10589997,10233996,10213313,10213312,9826718,9600078,9525894" href="/pubmed/17234232,11201791,11070895,10589997,10233996,10213313,10213312,9826718,9600078,9525894">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Gross cystic disease fluid protein-15 (GCDFP-15) binds to CD4, a T-cell co-receptor involved in antigen recognition, thereby inhibiting the ability of the receptor to interact with the HIV-1 envelope protein gp120</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 9724097" href="/pubmed/9724097">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Contact of CD4+ T cells with HIV-1 infected or HIV-1 gp120-expressing cells induces PARP hydrolysis, which leads to the cleavage of 116 kDa PARP into two fragments</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 9548463" href="/pubmed/9548463">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CD4-p56Lck interaction is required for HIV-1 gp120-induced nuclear translocation of NF-kappaB in HeLa cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 9621091" href="/pubmed/9621091">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Adsorption of multivalent gp120-containing HIV-1 virion particles into CD4+ T lymphocytes results in segregation of CD4 and CXCR4 into distinct lipid micro domains</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 11799176" href="/pubmed/11799176">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">A fusion protein between HIV-1 gp120 hepatitis B surface antigen (HBsAg) is capable of spontaneous assembly into virus-like particles and exhibits high affinity binding to CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 15033567,11453640" href="/pubmed/15033567,11453640">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Retrocyclin binds to soluble CD4 and HIV-1 gp120, colocalizes with CD4, CXCR4, and CCR5, and inhibits replication of CCR5-tropic and CXCR4-tropic strains of HIV-1 in human cells, presumably through inhibition of gp120-CD4 binding</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 14585219,12707350" href="/pubmed/14585219,12707350">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The level of HIV-1 gp120-mediated syncytium formation and infectivity is enhanced in the presence of neuraminidase (NA) and involves the interaction between gp120, CD4, and chemokine coreceptors</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 11352665" href="/pubmed/11352665">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CD26 (dipeptidyl peptidase IV) cleaves the highly conserved V3 loop of HIV-1 gp120 and functions as a cofactor for entry of HIV-1 in CD4+ human cells; coexpression of human CD4 and CD26 in murine NIH 3T3 cells renders them permissive to HIV-1</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 7903479" href="/pubmed/7903479">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Cells expressing a chimeric molecule consisting of the first 177 residues of CD4 attached to residues from the hinge, transmembrane, and cytoplasmic domains of CD8 are susceptible to fusion with cells expressing HIV-1 gp120</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 8411350" href="/pubmed/8411350">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Several polyanionic anti-HIV compounds, including dextran sulfate, pentosan polysulfate, heparin, aurintricarboxylic acid (ATA), suramin, and Evans blue, interact with HIV-1 gp120 to block the binding of gp120 to CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 15797855,9918507,9451022,8102473,8043225,7576913,7537501,7521897,1691563" href="/pubmed/15797855,9918507,9451022,8102473,8043225,7576913,7537501,7521897,1691563">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">A 287 residue variant of HIV-1 gp120 (ENV59) missing 197 amino acids binds to CD4 with high affinity</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 1537337" href="/pubmed/1537337">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Cell-cell contact between T cells expressing HIV-1 gp120/gp41 and other T cells expressing CD4 receptors leads to the rapid accumulation of cyclin B and tyrosine-hyperphosphorylated p34cdc2 (cdk1) kinase, indicative of cell cycle arrest at G2 phase</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 15719026,12145207" href="/pubmed/15719026,12145207">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 envelope protein gp120 can specifically inhibit CD4-dependent class II MHC-restricted T cell response to Antigens</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 17180012,16855325,16829607,9186786,8801439,8575195,8356059,8168144,7914230,7541827,2846691,2543930,2198840,1402655,1356673" href="/pubmed/17180012,16855325,16829607,9186786,8801439,8575195,8356059,8168144,7914230,7541827,2846691,2543930,2198840,1402655,1356673">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">95- and 25-kDa peptides derived from the disulfide bond reduction of HIV-1 gp120 bind to human CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 2842778" href="/pubmed/2842778">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The first two domains (amino acid residues 1-177) of human CD4 bind effectively to HIV-1 gp120, and most residues interacting with gp120 lie within amino acids 21-64; the COOH-terminal half of the molecule is not necessary</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23209523,21827143,17251298,16331979,12033937,10779509,8986758,8411350,3261864,3260352,2559777,2541915,2482055,2479005,2461565,2453925,2402498,2198840,2103853,2078013,2018763,1732513,1730924,1701782,1691226" href="/pubmed/23209523,21827143,17251298,16331979,12033937,10779509,8986758,8411350,3261864,3260352,2559777,2541915,2482055,2479005,2461565,2453925,2402498,2198840,2103853,2078013,2018763,1732513,1730924,1701782,1691226">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Amino acid sequences 397-439 in HIV-1 gp120 are directly involved in the binding of gp120 to the CD4 receptor</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 16315040,12477867,2559777,2558637,2550679,2482055,2441877" href="/pubmed/16315040,12477867,2559777,2558637,2550679,2482055,2441877">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Cleavage of HIV-1 gp120 with trypsin at residue 432 destroys CD4 binding</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 1763044" href="/pubmed/1763044">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Inhibition of HIV-1 binding to CD4 by suramin is reversed by human albumin, suggesting that only free suramin has antiviral properties</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 1810199" href="/pubmed/1810199">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 stimulates monocytes to release TNF-alpha, IL-1 beta, IL-6, and granulocyte-macrophage-CSF, and this effect can be blocked with soluble CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 9604776,8801439,1918997" href="/pubmed/9604776,8801439,1918997">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">T-tropic HIV-1 gp120s are capable of priming phorbol ester (PMA) induced co-down-modulation of gp120 complexes with tailless CD4 by interacting with CXCR4, whereas M-tropic gp120 are not, even in the presence of CCR5</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 10941932" href="/pubmed/10941932">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CD38 expression blocks lymphocyte susceptibility to HIV-1 infection by inhibiting HIV-1 gp120/CD4-dependent viral binding to target cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 10593874" href="/pubmed/10593874">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 induces CD4 association with lymphocyte surface molecules CD3, CD11a, CD27, CD45RA, CD45RB, CD45RO, CD49d, CD38, CD26, CD59, CD95 and class I MHC molecules</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 9263011" href="/pubmed/9263011">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 9377118" href="/pubmed/9377118">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/9629363">Envelope surface glycoprotein gp160, precursor</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp160 interacts with CD4; predicted interaction to be within the endoplasmic reticulum</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 27375898" href="/pubmed/27375898">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Env gp160 downregulates CD4 from the surface of infected cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26537682" href="/pubmed/26537682">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 glycoprotein gp160 binds to both cell surface receptor and soluble CD4 and the interaction of gp160 with CD4 results in virus-cell and cell-cell fusion</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25941367,25490553,25395053,24967714,24075869,23966389,23514633,22773820,22163344,22163292,21909273,21709254,21593147,21487012,21444771,21411542,21346189,21249232,19020832,18977142,18715908,18672260,18508887,17888880,17083721,15977243,15033690,14646564,11414813,11333908,10873786,10606089,9499113,9360974,9269777,8896248,8882662,8862276,8738430,8661397,8661396,8635586,8560759,8438588,8178478,8151301,8151300,8091666,7903106,7853478,7688827,7576930,7504739,2558687,2545918,2538547,2523711,2214026,2190605,2187500,2111957,2104682,1985202,1984054,1979339,1727497,1727486,1697332,1678778,1677023,1520872,1501294" href="/pubmed/25941367,25490553,25395053,24967714,24075869,23966389,23514633,22773820,22163344,22163292,21909273,21709254,21593147,21487012,21444771,21411542,21346189,21249232,19020832,18977142,18715908,18672260,18508887,17888880,17083721,15977243,15033690,14646564,11414813,11333908,10873786,10606089,9499113,9360974,9269777,8896248,8882662,8862276,8738430,8661397,8661396,8635586,8560759,8438588,8178478,8151301,8151300,8091666,7903106,7853478,7688827,7576930,7504739,2558687,2545918,2538547,2523711,2214026,2190605,2187500,2111957,2104682,1985202,1984054,1979339,1727497,1727486,1697332,1678778,1677023,1520872,1501294">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp160 molecules exist predominantly as a dimer, but higher forms corresponding to trimers and tetramers are also observed; multiple CD4 molecules bind to the gp160 oligomers</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25589637,25569572,25512514,25395053,24068931,23454641,17888880,8151300,1501294" href="/pubmed/25589637,25569572,25512514,25395053,24068931,23454641,17888880,8151300,1501294">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 heterotrimeric gp140 of inter- and intra-subtype combinations (subtype A, B, C, D and F) are shown to bind CD4 and a panel of neutralizing monoclonal antibodies with similar affinity to monovalent UG37 gp140</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25490553" href="/pubmed/25490553">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CD4 interaction with HIV-1 Env is necessary for contact induced cytoplasmic remodeling such as mitochondria polarization in HIV-1 infected T cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25320323" href="/pubmed/25320323">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The double alanine mutations at HIV-1 Env positions 671 and 674 result in attenuation of Env-mediated cell-cell fusion and hemifusion, as well as viral infectivity mediated by both CD4-dependent and CD4-independent viruses</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24075869" href="/pubmed/24075869">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CD4-linker-DC-SIGN fusion proteins enhance binding affinity to HIV-1 gp140 and gp120 in comparison to sCD4 and sDC-SIGN. These fusion proteins inhibit HIV-1 capture and transfer via DC-SIGN-expressing cells and iMDDCs</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22687513" href="/pubmed/22687513">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">DC-SIGN increases the binding affinity of trimeric gp140 envelope glycoproteins to CD4 on permissive cell surface</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22163292" href="/pubmed/22163292">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Env from subtype P downregulates CD4 cell surface expression</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22171785" href="/pubmed/22171785">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Binding gp140 to the synthetic CD4-mimicking mini protein leads to an outward domain shift of the three gp120 subunits, which diminishes gp120-gp41 interactions</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21444771" href="/pubmed/21444771">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">A soluble HIV-1 Env trimeric construct may better expose crucial epitopes such as the CD4 binding site and V3, as well as epitopes in the vicinity of gp41, subsequent to conjugation with the synthetic CD4-mimicking mini protein</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24068931,24067980,23757493,23426631,23267106,22773820,21444771" href="/pubmed/24068931,24067980,23757493,23426631,23267106,22773820,21444771">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Coexpression of HIV-1 gp160 and human CD4 in HeLa cells severely impairs HIV-1 gp120 production due to the formation of intracellular gp160-CD4 complexes; this CD4-mediated inhibition of gp160 processing is alleviated by coexpression of Vpu</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 8091666,7961587,1727486" href="/pubmed/8091666,7961587,1727486">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Interaction of HIV-1 gp160 with CD4 increases p56lck autophosphorylation and kinase activity</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 9989602,1548763,1535787" href="/pubmed/9989602,1548763,1535787">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">ICAM-1 promotes HIV-1 gp160-mediated syncytium formation, and the ICAM-1 contrareceptor LFA-1 attenuates the syncytium-inhibiting activity of virus-neutralizing monoclonal antibodies and soluble CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 17083721,7917519" href="/pubmed/17083721,7917519">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp160 and gp120 specifically recognize the C-terminal heparin-binding domain of fibronectin (Fn) and this binding inhibits the interaction of gp160/gp120 with soluble CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 9443108" href="/pubmed/9443108">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">A complete disappearance of surface CD4 preceding single-cell death occurs in cell clones expressing gp160, in which a complex between CD4 and gp160 is formed and then accumulates intracellularly</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22171785,18390744,16873261,8661397,8178478" href="/pubmed/22171785,18390744,16873261,8661397,8178478">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Newly synthesized CD4 and HIV-1 gp160 form a complex prior to transport from the endoplasmic reticulum (ER)</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 8661397,8409933,2214026,2111957,1727486" href="/pubmed/8661397,8409933,2214026,2111957,1727486">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Dimeric HIV-1 gp160 binds to two CD4 molecules</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 8151300,1501294" href="/pubmed/8151300,1501294">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp160 alone or CD4/gp160 cross-linking induces tyrosine phosphorylation of intracellular substrates p59fyn, zap 70, and p95vav and also leads to ras activation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 9344703,9269777" href="/pubmed/9344703,9269777">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Amino acid residues 257, 368, 370, and 457 of HIV-1 gp160 are critical for both cell surface and intracellular interaction between gp160 and CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21444771,8661396" href="/pubmed/21444771,8661396">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Interaction of the anchoring domain of HIV-1 gp160 with the endoplasmic reticulum membrane is responsible for gp160-mediated cell surface downregulation of CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 8661397" href="/pubmed/8661397">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/19172954">Envelope transmembrane glycoprotein gp41</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Enhanced CD4 binding activity of HIV-1 isolate R3A gp120/gp41 contributes to activate plasmacytoid dendritic cells (pDCs)</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25972534" href="/pubmed/25972534">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 and gp41 form a transitional complex with the CD4 receptor and CCR5/CXCR4 coreceptors during virus-cell and cell-cell membrane fusion</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25807248,25569556,25296255,25296251,25231990,25193376,24352444,23468626,23043103,22479399,22069466,22006924,21875413,21760891,21660189,21041720,20961591,20570309,20501362,20195464,20088758,20007245,19851458,19671162,19180463,19019953,18991615,18977142,18715908,18672260,18468560,18353949,18242797,18205925,18187620,17728240,17599917,17010381,15542675,15308751,15258189,15161081,14640682,14624372,14505910,12525600,10776787,8882662" href="/pubmed/25807248,25569556,25296255,25296251,25231990,25193376,24352444,23468626,23043103,22479399,22069466,22006924,21875413,21760891,21660189,21041720,20961591,20570309,20501362,20195464,20088758,20007245,19851458,19671162,19180463,19019953,18991615,18977142,18715908,18672260,18468560,18353949,18242797,18205925,18187620,17728240,17599917,17010381,15542675,15308751,15258189,15161081,14640682,14624372,14505910,12525600,10776787,8882662">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Divergent HIV-1 strains differ in their stoichiometry of entry and require between 1 to 7 HIV-1 gp120/gp41 trimers, with most strains depending on 2 to 3 trimers to complete entry through the interaction with CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25569556" href="/pubmed/25569556">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">SMS2, but not SMS1, is involved in enhancement of HIV-1 gp120/gp41-mediated membrane fusion through CD4 receptor and CCR5/CXCR4 coreceptors</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25231990" href="/pubmed/25231990">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Double alanine mutations at positions 671 and 674 of Env in the gp41 MPER region (residues 662-683) attenuate Env-mediated cell-cell fusion and hemifusion, as well as viral infectivity mediated by both CD4-dependent and -independent viruses</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25058619,24075869" href="/pubmed/25058619,24075869">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CD4 binding to HIV-1 gp120/gp41 trimers results in significant conformational changes in M150 and M161 in gp120 V1/V2 and F316 in gp120 V3, but causes little changes in M104, M95, and the triad of gp41 leucines</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25007222,24931470" href="/pubmed/25007222,24931470">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Shingopeptides disrupt HIV-1 gp41 fusion protein folding and CD4 receptor diffusion in vitro, suggesting that shingopeptides abolish the interaction of gp41 with CD4 in vivo</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24766462" href="/pubmed/24766462">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">A bivalent HIV-1 inactivator 2DLT by linking the D1D2 domain of CD4 to HIV-1 fusion inhibitor T1144 induces the formation of the gp41 prehairpin fusion-intermediate (PFI) and the T1144 domain in 2DLT then binds to the exposed PFI</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23217195" href="/pubmed/23217195">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 induces an elongated phenotype in infected CD4+ T cells. These HIV-infected T cells tether to other lymph node CD4+ cells and form syncytia through gp120/gp41, and migrate to distant tissues to disseminate</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22854780" href="/pubmed/22854780">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">A single Y681H substitution in HIV-1 gp41 increases the gp120-CD4 binding and enhances infectivity in low CD4 expressing cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22606344" href="/pubmed/22606344">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">A truncated cytoplasmic domain of 27 amino acids in HIV-1 gp41 can expose highly conserved domains involved in both HIV-1 coreceptor and CD4 binding</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 11861835" href="/pubmed/11861835">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Binding gp140 to the synthetic CD4-mimicking mini protein leads to an outward domain shift of the three gp120 subunits, which diminishes gp120-gp41 interactions</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21444771" href="/pubmed/21444771">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">A point mutation (V38E) in the gp41 region of HIV-1 abolishes HIV-1-mediated apoptosis by CASP3 and minimizes CD4 loss in humanized mice without altering viral replication</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21255440" href="/pubmed/21255440">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">In resting CD4 T cells, only the HIV envelope-mediated entry, but not the VSV-G-mediated endocytosis, can lead to viral DNA synthesis and nuclear migration</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 19851458" href="/pubmed/19851458">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The HIV-1 transmembrane glycoprotein gp41 is an amino acceptor and donor substrate for transglutaminase in vitro; soluble CD4 can block the transglutaminase-catalyzed incorporation of the polyamine spermidine into HIV-1 gp41</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 18242797,7688299" href="/pubmed/18242797,7688299">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Virological synapse-mediated cell-to-cell HIV-1 transfer is dependent upon gp120/gp41 and CD4 interactions and is more efficient than that of a cell-free mode of uptake, yet the presence of the full CD4 cytoplasmic tail is not essential for the process</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23219376,22553332,17728240" href="/pubmed/23219376,22553332,17728240">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Siva-1 sensitizes CD4-positive T-cells to HIV-1 gp120/gp41-induced apoptosis. The Siva-1-mediated sensitization on CD4-positive T-cells shows significant activation of caspase-3, -8, and -9</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 17653867" href="/pubmed/17653867">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CIITA-mediated enhancement of HIV-1 infection is gp120/gp41/CD4-dependent and occurs at the early steps in the infection cycle</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21041720" href="/pubmed/21041720">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Elimination of the CD4 domain 2 disulfide bond (Cys130-Cys159) by mutation enhances HIV-1 gp120/gp41-mediated cell-cell fusion and virus entry</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20974843" href="/pubmed/20974843">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/28872818">Nef</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef downregulates CD4 in primary HIV-1 infected CD4+ T cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26423947" href="/pubmed/26423947">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 NL4-3 Nef downregulates CD4, which requires the CPG-motif in Nef</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26700863" href="/pubmed/26700863">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 NL4-3 and SK68 Nef downregulate CD4, which is dependent upon a serine at position 88 in Nef</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26607225" href="/pubmed/26607225">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef and Vpu downregulate CD4 in an additive manner, which when inhibited allows for antibodies to bind CD4-Env and drive ADCC</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26637462" href="/pubmed/26637462">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef clinical isolates from chronic progressors downregulate CD4 to greater amounts than from elite controllers</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26719277" href="/pubmed/26719277">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 NL4-3, Sk68, SF2, and clinical isolates downregulate CD4 surface expression</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26719277,26607225,26523240" href="/pubmed/26719277,26607225,26523240">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef and Vpu downregulate CD4 expression; Nef and Vpu deletions reverse CD4 downmodulation in an additive fashion</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26497177" href="/pubmed/26497177">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 (SF2) Nef downregulates CD4; downregulation is dependent on the dileucine motif in Nef</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26656785" href="/pubmed/26656785">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 NA7 Nef downregulates CD4 surface expression; downregulation is dependent upon amino acid D186 in Nef</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 27560372" href="/pubmed/27560372">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">A dileucine motif in Nef is required for CD4 downregulation and for interaction with clathrin adaptor complexes AP-1 and AP-2, which are responsible for recruiting sorted proteins into clathrin-coated pits</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26656785,23151229,20622010,17947540,9811611,9811606,9052838" href="/pubmed/26656785,23151229,20622010,17947540,9811611,9811606,9052838">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef downregulates CD4 molecules from the cell surface of T, B, peripheral blood mononuclear and monocyte/macrophage cell lines as well as non-lymphoid cell lines</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26719277,26700863,26637462,26537682,26523240,26439863,26423947,25972534,25827531,25807049,25525794,25505066,25496667,25423108,25275127,25193656,25118280,25062432,24965469,24904546,24789790,24748005,24706755,24705461,24620746,24495362,24489825,24473078,24465014,24352444,24187576,24172637,24058696,24041011,24023945,23986795,23853598,23847689,23490051,23289738,23215766,23202450,23170180,23151229,22980333,22844345,22808111,22640559,22479639,22345473,22301152,22301137,22291690,22175768,22171785,22103838,22103834,22103833,22103832,22103831,22013062,21917951,21861776,21845735,21543478,21482738,21165790,21068258,20881088,20826747,20638642,20594957,20465832,20463068,20380698,20012528,19917496,19895210,19770068,19643141,19449444,19439470,19403684,19327048,19324886,19149577,19146681,19129443,18808677,18725938,18541215,18473783,18438604,17947540,17904606,17824250,17652391,17632570,17632197,17586321,17329339,16454711,15638726,8437228,7903128,7902127,3118220,2014052,1565858" href="/pubmed/26719277,26700863,26637462,26537682,26523240,26439863,26423947,25972534,25827531,25807049,25525794,25505066,25496667,25423108,25275127,25193656,25118280,25062432,24965469,24904546,24789790,24748005,24706755,24705461,24620746,24495362,24489825,24473078,24465014,24352444,24187576,24172637,24058696,24041011,24023945,23986795,23853598,23847689,23490051,23289738,23215766,23202450,23170180,23151229,22980333,22844345,22808111,22640559,22479639,22345473,22301152,22301137,22291690,22175768,22171785,22103838,22103834,22103833,22103832,22103831,22013062,21917951,21861776,21845735,21543478,21482738,21165790,21068258,20881088,20826747,20638642,20594957,20465832,20463068,20380698,20012528,19917496,19895210,19770068,19643141,19449444,19439470,19403684,19327048,19324886,19149577,19146681,19129443,18808677,18725938,18541215,18473783,18438604,17947540,17904606,17824250,17652391,17632570,17632197,17586321,17329339,16454711,15638726,8437228,7903128,7902127,3118220,2014052,1565858">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef core domain directly interacts with CD4 and is highly conserved amongst Nef from [the] HIV-1/-2/SIV strains [tested] in 293T cells as shown by FACS-Forster resonance energy transfer (FRET)- and site-directed mutagenesis-based experiments</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26423947" href="/pubmed/26423947">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 (NL4-3) Nef downregulates CD4 via a cullin-RING E3 ubiquitin ligase complex- independent mechanism</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26215564" href="/pubmed/26215564">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 isolate R3A Nef mutants G2, WL58, RR106, LL165, E160NNSLL165, and DD175 fail to induce release of IFN-alpha in pDCs, suggesting that the Nef function responsible for CD4 downregulation is crucial for pDCs stimulation by R3A</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25972534" href="/pubmed/25972534">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef clones from acute controllers display a lesser ability to downregulate CD4 and HLA class I from the cell surface, and a reduced ability to enhance virion infectivity compared to those from acute progressors</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24965469" href="/pubmed/24965469">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef-mediated CD4 degradation requires ALIX and interaction of Nef with ALIX in endosomes containing CD4 in cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25118280" href="/pubmed/25118280">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef mutants D108K, R134E, E177K, DD174/175AA do not downregulate CD4 on cell surface of HeLa cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24473078" href="/pubmed/24473078">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">Deletion of both HIV-1 nef and vpu genes enhance a significant engagement between HIV-1 gp120 and CD4 at the cell surface, suggesting Nef and Vpu prevent the exposure of epitopes recognized by anti-gp120 antibody-dependent cell-mediated cytotoxicity</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24352444" href="/pubmed/24352444">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">Neffin, a camelid single-domain antibody fragment (termed sdAb19) fused to the SH3 domain of Nef, strongly binds to HIV-1 Nef with a stoichiometric 2:2 ratio and inhibits Nef-mediated downregulation of CD4 in HeLa-CD4 cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24620746" href="/pubmed/24620746">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">Interaction of HIV-1 Nef with AP-2 alpha-sigma dimer is required for Nef-mediated CD4 downregulation. The dileucine L164L165 and M168L170 motifs bind to the sigma unit, while the acidic motif E174 and D175 binds to the alpha unit</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24473078,23151229" href="/pubmed/24473078,23151229">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef clones, isolated from plasma of elite controllers (EC) and chronic progressors (CP), show significantly lower CD4 downregulation activity in EC than that in CP</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23289738" href="/pubmed/23289738">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef clones obtained from chronic patients infected with HIV-1 subtypes A, B, C or D show a functional hierarchy of subtype B > A/D > C for Nef-mediated CD4 downregulation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24041011" href="/pubmed/24041011">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">Functional ARF1 is required for HIV-1 Nef-dependent endogenous HLA-A2 and CD4 downregulation in HIV-infected primary T cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21917951" href="/pubmed/21917951">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">The hydrophobic region (residues 168-173) downstream of the HIV-1 Nef dileucine motif (L164L165) is involved in HIV-1 Nef-mediated CD4 downregulation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23151229" href="/pubmed/23151229">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef enhances the infectivity of CD4-chemokine receptor-pseudotyped HIV-1 for target cells expressing HIV-1 Env. Virus-producing cells expressing dominant-negative dynamin 2 (K44A) selectively inhibits these receptor-pseudotyped virions</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 18715908" href="/pubmed/18715908">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">CD4 and MHC-1 downregulation are highly conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variable</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21165790,16979207" href="/pubmed/21165790,16979207">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef mutants LLAA and delta12-39 significantly impair downregulation of CD4. Nef LLAA mutant fails to interact with the endocytic machinery and Nef delta12-39 mutant lacks the interaction with the Nef-associated kinase complex</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 19146681" href="/pubmed/19146681">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef drastically reduces the ratio of CD4 dimers/monomers</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20739067" href="/pubmed/20739067">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">beta-COP as a cellular cofactor is required for HIV-1 Nef-mediated HLA-A2, CD4, and CD8 downregulation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21543478" href="/pubmed/21543478">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">Single mutation at the ubiquitination residue K144 or at the tyrosine motif Y202F203 in HIV-1 Nef greatly impairs Nef-mediated CD4 downregulation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21482738,18523251" href="/pubmed/21482738,18523251">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">TPCK and TLCK alkylation reagents chemically modify HIV-1 Nef at residues Cys55 and Cys206. Cys55 modification reduces the strength of the interaction between Nef and CD4 tail peptide</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20659345" href="/pubmed/20659345">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef expression from unintegrated HIV-1 DNA downregulates the surface levels of CD4, CCR5, and CXCR4 on T-lymphocytes and monocytes</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22808111,20465832" href="/pubmed/22808111,20465832">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef interacts with CD4 in living cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20179761" href="/pubmed/20179761">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef targets CD4 to CD63-containing lysosomes for Nef-induced degradation of CD4, which requires the VPS4-mediated ESCRT machinery</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 19403684" href="/pubmed/19403684">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">K295, K297, K298, and R340 basic residues on the AP-2 alpha subunit are required for its binding to HIV-1 Nef. The K297 and R340 residues are required for Nef-induced CD4 downregulation and the cooperative assembly of a Nef-CD4-AP-2 complex</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 19129443" href="/pubmed/19129443">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">L37, P78 and E177 residues of HIV-1 Nef are required for its effect on CD4 internalization and recycling but dispensable for Nef-induced retention and degradation of intracellular CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 17947540" href="/pubmed/17947540">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef-Vpr fusion proteins are efficiently incorporated into HIV-1 particles and possess CD4 downregulation activity in target cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 18987145" href="/pubmed/18987145">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">An intact Nef dimerization interface, including the multiple hydrophobic (I109, L112, Y115, and F121) and electrostatic (R105 and D123) residues, is required for Nef-induced CD4 downregulation in cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 19781555" href="/pubmed/19781555">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">An intact hydrophobic interface (residues I109, L112, Y115, and F121) is essential for HIV-1 Nef dimerization in cells and is required for Nef-mediated CD4 receptor downregulation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 19781555" href="/pubmed/19781555">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpr increases expression of Nef protein from integrase-defective HIV-1. The Vpr-mediated expression of Nef from IN-minus HIV-1 results in CD4 downregulation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 17652391" href="/pubmed/17652391">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">Expression of p56(lck) in nonlymphoid CD4-expressing cells restores the ability of Nef in order to increase the internalization rate of CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 19439470" href="/pubmed/19439470">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef downregulates CD4 expression on the surface of Jurkat cells and blocks the CD3 signaling pathway; mutations at amino acids 174 and 175 reduce the ability of Nef to downregulate CD4 expression</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21922073,20012528,18808677,18541215,18473783,18438604,17632570,17346169,17267500,17170457,17077296,17042973,16873261,16684552,16476977,16454711,16354571,16310238,16091223,15078178,14965316,12836198,12734410,9473011,9049297" href="/pubmed/21922073,20012528,18808677,18541215,18473783,18438604,17632570,17346169,17267500,17170457,17077296,17042973,16873261,16684552,16476977,16454711,16354571,16310238,16091223,15078178,14965316,12836198,12734410,9473011,9049297">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">The HIV-1 Nef mutant F12-HIVNef, containing three rare amino acid substitutions, G(140)E, V(153)L and E(177)G, represses Nef-induced accelerated rates of CD4 internalization and p62NAK activation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 11602785" href="/pubmed/11602785">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">Deletion of the 19 N-terminal amino acids, including the myristoylation signal from HIV-1 Nef inhibits both MHC-I and CD4 downregulation while preserving most CTL, T-helper and B-cell epitopes</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 11578695,8057354" href="/pubmed/11578695,8057354">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">Different levels of CD4 modulation are induced by different HIV-1 Nef proteins derived from HIV-1 infected adults and children</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 14557639,11396948" href="/pubmed/14557639,11396948">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">The functional ability of HIV-1 Nef to downregulate CD4, but not MHC class I, is associated with Nef-mediated enhancement of HIV-1 pathogenicity in severe combined immunodeficiency (SCID) mice implanted with human fetal thymus and liver</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 12525647,10684310" href="/pubmed/12525647,10684310">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">CD4 downregulation by HIV-1 Nef enhances the efficiency of HIV-1 replication in both activated human primary T lymphocytes and lymphoid tissues; Nef-induced CD4 downregulation correlates with severe depletion of CD4+ T cells in lymphoid tissues</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23215766,23202450,23170180,17083721,12842621,12816953,11932428,11581379,10451539" href="/pubmed/23215766,23202450,23170180,17083721,12842621,12816953,11932428,11581379,10451539">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">Expression of HIV-1 Nef in human monocyte-derived dendritic cells using an adenovirus based delivery system decreases CD4 levels, but has no effect on class I MHC</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 14670336" href="/pubmed/14670336">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef downregulates CD4 in Jurkat cells in a concentration-dependent manner</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 11438519" href="/pubmed/11438519">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef mutants C142A and K158A/E160G exhibit a temperature-dependent ability to downregulate CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 8599214" href="/pubmed/8599214">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef downregulates CD4 rapidly during the early phase of virus infection, whereas HIV-1 Vpu and Env function late in the infection; in primary cells, down-modulation of CD4 has a stronger dependence on Nef function for reducing cell surface CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 8709227" href="/pubmed/8709227">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">High levels of CD4 on the surface of an HIV-1 producing cell block viral infectivity by interfering with incorporation of HIV-1 envelope into the virion; HIV-1 Nef and Vpu inhibit this block by downregulating CD4 from the cell surface</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 10375528,10375525" href="/pubmed/10375528,10375525">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">Mutational analysis of HIV-1 Nef shows that a membrane targeting domain (residues 2-7) and a conserved glutamic acid-rich segment (residues 60-71) are required for CD4 downregulation but not for viral infectivity enhancement</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 15854903,7769669" href="/pubmed/15854903,7769669">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef downregulates cell surface expression of CD4 in CEM Nef+ cells by promoting the accumulation of CD4 in an acidic early endosome</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 7983750" href="/pubmed/7983750">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">An isoleucine residue at position 410 and two leucine residues at positions 413 and 414 in CD4 are required for HIV-1 Nef-mediated CD4 downregulation in cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 9168885" href="/pubmed/9168885">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">Two distinct regions within HIV-1 Nef, amino acid residues 96-144 and 175-186, are required for CD4 downregulation in cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 19781555,9168885" href="/pubmed/19781555,9168885">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">The presence of an alpha-helix in CD4, which extends from residues Gln403 to Arg406, promotes the binding of CD4 to HIV-1 Nef</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 11922627" href="/pubmed/11922627">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">Yeast two-hybrid assays show that a nearly complete HIV-1 Nef protein is required for binding to the CD4 cytoplasmic domain (residues 394-416), and the dileucine motif in CD4 (residues 413-414) is essential for this direct interaction</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21625496,8599229" href="/pubmed/21625496,8599229">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">Solution NMR spectroscopy studies show a 13 amino acid peptide (residues 407-419) derived from the CD4 cytoplasmic domain binds directly to HIV-1 Nef in a manner that involves amino acid residues 57-59, 95-97, 106, and 110 in Nef</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21738584,11264384,8599760" href="/pubmed/21738584,11264384,8599760">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">CEM cells stably transfected with a replication-defective provirus of HIV-1 that has a rev-splicing mutation and expresses an intact nef gene have markedly reduced cell surface expression of CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 7975260" href="/pubmed/7975260">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef-mediated downregulation of CD4 is induced by an accelerated dissociation of the T-cell tyrosine kinase Lck and CD4, and a decrease in the half-life of CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 19439470,16454711,16354571,10208934,8151774,8035515,7871751,7831289" href="/pubmed/19439470,16454711,16354571,10208934,8151774,8035515,7871751,7831289">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">A dileucine motif in the cytoplasmic domain of CD4 is involved in the association of CD4 with the tyrosine kinase Lck and the downregulation of CD4 by HIV-1 Nef, however Nef does not induce dissociation of Lck from CD4 in acutely HIV-infected cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21625496,8871625" href="/pubmed/21625496,8871625">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">A dileucine motif in the cytoplasmic tail of CD4 is not required for HIV-1 Nef binding in insect cells, but is essential for Nef-induced CD4 downregulation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 13679604" href="/pubmed/13679604">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">Experiments using both a recombinant HIV-1 Integrase-defective virus and a diketo acid Integrase inhibitor demonstrate that HIV-1 Nef expressed from extra chromosomal DNA (E-DNA) downregulates CD4 surface expression on primary CD4(+) T lymphocytes</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 15722538" href="/pubmed/15722538">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">The Nef protein from the primary virus isolate HIV-1 KS2 lacks two glutamic acid residues (EE154-5) and has a decreased ability to downregulate CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 15166428" href="/pubmed/15166428">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 expressing Nef proteins defective in CD4 downregulation activity retain wild-type levels of infectivity in single-round assays, but exhibit delayed replication kinetics and lower titers compared to the wild-type virus in monocyte-derived macrophages</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 15166429" href="/pubmed/15166429">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">PMA treatment of T cells expressing HIV-1 Nef, which downregulates CD4, restores cell surface CD4 up to 35%; mutations in the phosphorylation sites of the CD4 cytoplasmic tail (Ser408 and Ser415) abolish this effect of PMA</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 15494497" href="/pubmed/15494497">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef-mediated CD4 downregulation is profoundly inhibited by the synergistic effect of Eps15DIII, a dominant negative mutant of Eps involved in endocytosis and RNA interference of AP-2 expression</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 17267500,16116206" href="/pubmed/17267500,16116206">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">Bioluminescence resonance energy transfer (BRET) and co-immunoprecipitation assays have been used to demonstrate the interaction of HIV-1 Nef and CD4 in intact human cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 15956605" href="/pubmed/15956605">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 group N and group O Nef alleles only weakly downregulate CD4, CD28, and class I and II MHC molecules</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 15194762" href="/pubmed/15194762">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">A dileucine motif in the CD4 cytoplasmic domain is required for its downregulation by HIV-1 Nef; cysteine residues in the cytoplasmic domain of CD4 are essential for the binding of Lck but are not required for Nef-induced downregulation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21625496,18541215,18473783,15854903,11463741,8151774,8124721,7831289" href="/pubmed/21625496,18541215,18473783,15854903,11463741,8151774,8124721,7831289">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef induces drastic and moderate downregulation of CD4 and MHC-I in resting CD4(+) T lymphocytes, respectively, but markedly upregulates cell surface levels of the MHC-II invariant chain CD74</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23215766,23202450,23170180,21165790,16439540,16365153" href="/pubmed/23215766,23202450,23170180,21165790,16439540,16365153">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef forms a ternary complex with ARF1 and beta-COP in endosomes, which facilitates Nef-induced downregulation and transport of CD4 to acidic late-endosomal compartments</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 18725938,15202998" href="/pubmed/18725938,15202998">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef-induced CD4 degradation is regulated by a highly conserved diacidic-based motif in Nef that acts as a lysosomal targeting signal through the binding of beta-COP in endosomes</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 18725938,11264386,10199403,7982906" href="/pubmed/18725938,11264386,10199403,7982906">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">Nef from primary isolates of HIV-1 suppresses surface CD4 expression in human and mouse T cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 8331733" href="/pubmed/8331733">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">Transduction of the HIV-1 nef gene into murine cells expressing human, chimpanzee, or murine CD4 induces cell surface downregulation of all three molecules; the cytoplasmic domain of CD4 is required for its downregulation by Nef</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 8437228" href="/pubmed/8437228">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">In adult HIV-1 Nef transgenic mice, CD4 downregulation is found in CD4- and CD8-double positive thymocytes; co-localization of CD4 with a Golgi-specific marker indicates Nef interferes with CD4 intracellular trafficking</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22103836,16454711,8262036" href="/pubmed/22103836,16454711,8262036">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">CD4 is downregulated by nef alleles isolated from peripheral blood leukocytes of HIV-1-infected individuals; Nef proteins with point mutations at positions Gly2, Asp36, Cys122, and Val148 exhibit different levels of CD4 downregulation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24041011,21165790,8516299" href="/pubmed/24041011,21165790,8516299">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">CD4 downregulation by HIV-1 Nef is independent of the level of CD4 mRNA expressed in cells and of the level of CD4 serine phosphorylation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 2014052" href="/pubmed/2014052">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">Overexpression of Nef-associated factor 1, Naf1, increases cell surface CD4 expression; HIV-1 Nef suppresses this activity of Naf1 to downregulate CD4 expression</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 9923610" href="/pubmed/9923610">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/9629360">Pr55(Gag)</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Gag colocalizes with CD4 on bystander cells in virological synapses in Cos7 cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 27170746" href="/pubmed/27170746">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Gag/p24 co-localizes with CD4 in the intracellular CD4+ compartments in primary T lymphocytes</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 27170746,22846998" href="/pubmed/27170746,22846998">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">The rapid kinetics of HIV-1 Gag transfer corresponds to similar time-dependent increases in CD4+ T cell infection from HIV-1 infected monocyte-derived macrophages</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25320323,24307588" href="/pubmed/25320323,24307588">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Gag-positive uropods form contacts enriched in CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21060818" href="/pubmed/21060818">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/9629358">Tat</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Tat-induced upregulation of miR-222 results in the post-transcriptional inhibition of CD4 expression</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24717285" href="/pubmed/24717285">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">CD4 and CD1a surface expression are greatly decreased in Tat expression Jurkat cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24717285,20139419" href="/pubmed/24717285,20139419">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">Expression of HRES-1/Rab4 is induced by HIV-1 tat, which in turn down-regulates expression of CD4 and susceptibility to re-infection by HIV-1</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 18432409" href="/pubmed/18432409">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Tat upregulates mRNA expression and cell surface levels of CD4 antigen in Jurkat cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 17001685,16354571,2845147" href="/pubmed/17001685,16354571,2845147">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/9629361">Vif</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155459">vif</a>
|
||
</td>
|
||
<td headers="hivinter">Vif plays an important role in promoting HIV-1 binding to CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22017399,8924209" href="/pubmed/22017399,8924209">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/28872817">Vpr</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155807">vpr</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef-Vpr fusion proteins are efficiently incorporated into HIV-1 particles and possess CD4 downregulation activity in target cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 18987145" href="/pubmed/18987145">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155807">vpr</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpr increases expression of Nef protein from integrase-defective HIV-1. The Vpr-mediated expression of Nef from IN-minus HIV-1 results in CD4 downregulation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 17652391" href="/pubmed/17652391">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155807">vpr</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpr downregulates the expression of surface CD4 receptors in Jurkat T cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 19275586,17652391,16354571,11024150" href="/pubmed/19275586,17652391,16354571,11024150">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/9629366">Vpu</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef and Vpu downregulate CD4 in an additive manner, which when inhibited allows for antibodies to bind CD4-Env and drive ADCC</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26637462" href="/pubmed/26637462">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef and Vpu downregulate CD4 expression; Nef and Vpu deletions reverse CD4 downmodulation in an additive fashion</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26497177" href="/pubmed/26497177">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 (NL4-3) Vpu downregulates CD4; downregulation is dependent on the presence of serines at positions 52 and 56 in Vpu</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26656785" href="/pubmed/26656785">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">The C-terminal domain of HIV-1 Vpu (amino acids 76-81) interacts with the cytoplasmic domain of CD4 (amino acids 402-425) and causes the rapid degradation of CD4 in the endoplasmic reticulum</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26463207,24822052,24158820,24035804,23831603,22863293,22751485,22171785,21922073,21674066,21607084,21601230,21176220,20858517,20638642,20201792,20012522,18541215,15929700,10375528,9622505,9151836,9049413,8887470,8806575,8709227,8551619,8510209,8350411,8289353,8230446,8091684,8091666,7853484,7778293,1433512" href="/pubmed/26463207,24822052,24158820,24035804,23831603,22863293,22751485,22171785,21922073,21674066,21607084,21601230,21176220,20858517,20638642,20201792,20012522,18541215,15929700,10375528,9622505,9151836,9049413,8887470,8806575,8709227,8551619,8510209,8350411,8289353,8230446,8091684,8091666,7853484,7778293,1433512">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Downregulation of CD4 from the surface of HIV-1 infected cells by HIV-1 Vpu increases viral infectivity</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26656785,26637462,26497177,25872908,25827531,25275127,24822052,24551192,24352444,23831603,23218949,22980333,22357275,22301152,22291690,21922073,21310048,21176220,20201792,19917496,18789977,18672082,18579178,17346169,17121803,12842621,12746459" href="/pubmed/26656785,26637462,26497177,25872908,25827531,25275127,24822052,24551192,24352444,23831603,23218949,22980333,22357275,22301152,22291690,21922073,21310048,21176220,20201792,19917496,18789977,18672082,18579178,17346169,17121803,12842621,12746459">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu downregulates cell (CEMT4, Primary CD4+ T cells) surface expression of CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26439863,26215564" href="/pubmed/26439863,26215564">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu downregulates CD4 and is dependent on neddylation (covalent addition of NEDD8 onto a lysine residue on cullin backbone inducing conformational change in the cullin-RING E3 ubiquitin ligase complex rendering enzyme catalytically active) via NAE1</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26215564" href="/pubmed/26215564">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu mediates retention of CD4 in the ER. Transmembrane domain interactions are the main determinant of ER retention of CD4 by Vpu</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24822052,23831603,21176220,20442859" href="/pubmed/24822052,23831603,21176220,20442859">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Poly-ubiquitination of the CD4 cytosolic tail by SCFbeta-TrCP is required for HIV-1 Vpu-induced CD4 degradation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24822052,21176220,20201792,17937819" href="/pubmed/24822052,21176220,20201792,17937819">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu mediated degradation of CD4 requires the function of proteasomes and results from the formation of a ternary complex between beta-TrCP, Vpu and CD4 which connects CD4 to the endoplasmic reticulum degradation pathway</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24822052,24574397,24257748,24158820,24035804,23831603,23308067,23201263,22222210,22171785,21994772,21176220,20880565,20442859,20201792,20012522,19944437,19149577,18672082,18541215,17937819,17586316,17121803,16354571,15279589,15099523,14561767,9660940,9499087" href="/pubmed/24822052,24574397,24257748,24158820,24035804,23831603,23308067,23201263,22222210,22171785,21994772,21176220,20880565,20442859,20201792,20012522,19944437,19149577,18672082,18541215,17937819,17586316,17121803,16354571,15279589,15099523,14561767,9660940,9499087">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Deletion of both HIV-1 nef and vpu genes enhance a significant engagement between HIV-1 gp120 and CD4 at the cell surface, suggesting Nef and Vpu prevent the exposure of epitopes recognized by anti-gp120 antibody-dependent cell-mediated cytotoxicity</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24352444" href="/pubmed/24352444">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Biotinylation technique in living cells demonstrates HIV-1 Vpu-induced retro-translocation of CD4 travels with oxidized intrachain disulfide bridges and accumulates in the cytosol as reduced and deglycosylated molecules only upon proteasomal inhibition</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24257748" href="/pubmed/24257748">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu mutations (A19E, E29K, II43,46SL, R49G/T, SN53,55RH, S53N, E58K) derived from HIV-1 infected patients have defects for both CD4 and tetherin downregulation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24465210" href="/pubmed/24465210">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Individual Vpu proteins isolated from chronically or acutely infected patients differ substantially in their CD4 and tetherin downregulation function at the cell surface</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24574397,24465210" href="/pubmed/24574397,24465210">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu interacts with CD4 in living cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24257748,20179761" href="/pubmed/24257748,20179761">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Cell surface CD4 inhibits HIV-1 particle release by interfering with Vpu activity, possibly by disrupting the oligomeric structure of Vpu</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24574397,10559275" href="/pubmed/24574397,10559275">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu regulates the formation of intracellular HIV-1 gp160-CD4 complexes and liberates Golgi-targeted gp160 from CD4-dependent retention in the endoplasmic reticulum</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24400003,18672082,7961587,1727486" href="/pubmed/24400003,18672082,7961587,1727486">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Chimeras between the TMD of HIV-1 M Vpu and the cytoplasmic domains of SIVcpzPtt, SIVcpzPts, and SIVgor Vpu proteins are capable of binding to human CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23514615" href="/pubmed/23514615">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">A combination of molecular dynamics simulations and docking approaches shows the lowest energy structure of Vpu-CD4, indicating that the residues Leu-419 and Ile-416 in CD4 interact with the alanine rim (Ala-8/11/15/19) of Vpu</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24036078" href="/pubmed/24036078">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Magic angle sample spinning NMR analysis confirms the correct insertion of the transmembrane domains from both HIV-1 Vpu and CD4 (residues 372-433) into the lipid bilayers</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23863698" href="/pubmed/23863698">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">The Val20 and Ser23 residues within the Vpu TMD are critical for Vpu-induced CD4 retention in the ER</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22090097" href="/pubmed/22090097">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Mutation of the HIV-1 Vpu Trp22 does not prevent Vpu-CD4 interaction but enhances Vpu oligomerization. The CD4 Gly415 residue within the CD4 TMD is required for both Vpu-CD4 interaction and Vpu-induced CD4 degradation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22090097" href="/pubmed/22090097">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">The HIV-1 Vpu Trp22 mutation in the Vpu transmembrane domain fails to induce CD4 degradation by reduced CD4 polyubiquitination. The Trp residue is highly conserved in all HIV-1 Vpu variants, including those of HIV-1 groups M, N, and O</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22090097" href="/pubmed/22090097">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">NMR analysis indicates that amino acids (residues 39-48 and 64-70) in both helices of the HIV-1 Vpu cytoplasmic region are important for its binding to CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22863293" href="/pubmed/22863293">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Tetherin delGPI mutant directly interacts with HIV-1 Vpu and inhibits Vpu-induced degradation of tetherin and CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23201263" href="/pubmed/23201263">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">The putative cholesterol recognition amino acid consensus (CRAC) motif (residues 25-31) of HIV-1 Vpu mediates lipid raft association of Vpu and affects the downregulation of cell surface CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22222210" href="/pubmed/22222210">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu from subtype P can downregulate CD4 from cell surface</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22171785" href="/pubmed/22171785">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Downregulation of CD4 and BST2 by HIV-1 Vpu is observed in HIV-1 infected humanized mice</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22357275" href="/pubmed/22357275">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">SCYL2 inhibits Vpu-induced BST2 and CD4 reduction at the cell surface by suppressing the phosphorylation of Vpu at positions Ser-52 and Ser-56</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23047923" href="/pubmed/23047923">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Co-expression of HIV-1 Vpu with beta-TrCP2 induces degradation of total cellular CD4 content; Vpu-mediated CD4 down-modulation is inhibited by double silencing of beta-TrCP1 and beta-TrCP2</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21310048,21176220,20201792,19149577,17121803" href="/pubmed/21310048,21176220,20201792,19149577,17121803">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">The invariant leucine 63 and the valine 68 within the predicted second alpha-helical domain of the HIV-1 Vpu cytoplasmic tail are required for CD4 down-modulation. L63A and V68A mutants still bind CD4 and retain the ability to interact with beta-TrCP1</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21176220,19944437" href="/pubmed/21176220,19944437">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Replication-defective Vpu TM mutants (V9D and I19D) and cytoplasmic domain mutants (S56G and E59K) fail to downregulate cell surface CD4, suggesting that viral replication potential and ability to downregulate CD4 by Vpu are correlated</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21607084" href="/pubmed/21607084">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu Y35A/L39G mutant has a significant increase in CD4 surface expression compared to wild-type Vpu</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20201792,18579178" href="/pubmed/20201792,18579178">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu proteins from pandemic HIV-1 M strains, but not from nonpandemic HIV-1 N strains, degrade the viral receptor CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23514615,23308067,21176220,20201792,19917496" href="/pubmed/23514615,23308067,21176220,20201792,19917496">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">The VCP-UFD1L-NPL4 complex is required for HIV-1 Vpu-induced CD4 degradation in the ER-associated degradation pathway. The ATPase activity of VCP and ubiquitin binding to UFD1L are important for CD4 degradation by Vpu</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21176220,20442859" href="/pubmed/21176220,20442859">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">A simian-human immunodeficiency virus (SHIVtm) with a scrambled amino acid sequence in the transmembrane domain of HIV-1 Vpu fails to downregulate cell surface expression of CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21176220,15975620" href="/pubmed/21176220,15975620">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Phosphorylation of HIV-1 Vpu on two serine phosphoacceptor sites (amino acids 52 and 56) by casein kinase 2 is required for Vpu-mediated degradation of CD4 in the endoplasmic reticulum</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23284757,23047923,22751485,21674066,21607084,21176220,20858517,20201792,20078884,20012522,19149577,17586316,12954211,11024464,9185604,8659106,8139011" href="/pubmed/23284757,23047923,22751485,21674066,21607084,21176220,20858517,20201792,20078884,20012522,19149577,17586316,12954211,11024464,9185604,8659106,8139011">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
<p class="withnote">
|
||
<a class="note" href="/genome/viruses/retroviruses/hiv-1/interactions/">Go to the HIV-1, Human Interaction Database </a>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-pathways">
|
||
<section class="rprt-section-header" id="pathways">
|
||
<h2 id="header-pathways">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-pathways .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Pathways from PubChem</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<ul class="geneinfo-subsec infopathway">
|
||
<iframe title="Pathways in which the gene target is involved" class="pubchem-widget" scrolling="no" src="https://pubchem.ncbi.nlm.nih.gov/gene/920#section=Pathways&embed=true&hide_all_headings=true&page_size=25" style="border: 0; width: 100%;"></iframe>
|
||
<script type="text/javascript" src="https://pubchem.ncbi.nlm.nih.gov/pcfe/libs/iframeResizer.min.js"></script>
|
||
<script type="text/javascript">iFrameResize({log: false, checkOrigin: false}, '.pubchem-widget')</script>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-interactions">
|
||
<section class="rprt-section-header" id="interactions">
|
||
<h2 id="header-interactions">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-interactions .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Interactions</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Interactions" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<table summary="Gene Interaction" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/920/data/interaction/',webserviceParams: 'p$l=Ajax&p$debugoutput=off', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
|
||
<thead>
|
||
<tr>
|
||
<th id="inter-prod">Products</th>
|
||
<th id="inter-interactant">Interactant</th>
|
||
<th id="inter-otherGene">Other Gene</th>
|
||
<th id="inter-compl">Complex</th>
|
||
<th id="inter-source">Source</th>
|
||
<th id="inter-pubs">Pubs</th>
|
||
<th id="inter-desc">Description</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody></tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-general-gene-info">
|
||
<section class="rprt-section-header" id="general-gene-info">
|
||
<h2 id="header-general-gene-info">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-gene-info .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">General gene information</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.General_Gene_Information" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
|
||
<div class="rprt-section-body" style="">
|
||
<div id="gene-markers">
|
||
<h3 id="markers">
|
||
<a class="jig-ncbitoggler">Markers</a>
|
||
</h3>
|
||
<div>
|
||
<ul class="marker odd">
|
||
<li class="marker">GDB:212646 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=156168%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=920&link_uid=156168">UniSTS:156168</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">D11S2921 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=152074%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=920&link_uid=152074">UniSTS:152074</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">GDB:434012 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=157204%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=920&link_uid=157204">UniSTS:157204</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">CD4_1639 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=277076%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=920&link_uid=277076">UniSTS:277076</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">A007D38 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=63828%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=920&link_uid=63828">UniSTS:63828</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">SHGC-152382 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=177495%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=920&link_uid=177495">UniSTS:177495</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">L18426 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=34648%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=920&link_uid=34648">UniSTS:34648</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">D1S1423 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=149619%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=920&link_uid=149619">UniSTS:149619</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">D1S1425 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=149621%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=920&link_uid=149621">UniSTS:149621</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">SHGC-12737 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=30349%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=920&link_uid=30349">UniSTS:30349</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">GDB:625824 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=158369%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=920&link_uid=158369">UniSTS:158369</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">GDB:195161 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=155810%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=920&link_uid=155810">UniSTS:155810</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">GDB:625827 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=158370%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=920&link_uid=158370">UniSTS:158370</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">GDB:384737 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=157092%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=920&link_uid=157092">UniSTS:157092</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">L18441 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=71348%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=920&link_uid=71348">UniSTS:71348</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">PMC155019P1 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=271320%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=920&link_uid=271320">UniSTS:271320</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">GDB:180736 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=155114%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=920&link_uid=155114">UniSTS:155114</a></li></ul></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div></div>
|
||
|
||
<div class="infosec">
|
||
<h3 id="homology">
|
||
<a class="jig-ncbitoggler-open">Homology</a>
|
||
</h3>
|
||
<ul class="geneinfo-subsec">
|
||
<li>
|
||
<a href="/gene/920/ortholog/" id="ncbi-ortholog-link">NCBI Orthologs</a>
|
||
</li>
|
||
<a href="https://www.orthodb.org/?ncbi=920" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=8178" target="_blank">
|
||
Orthologs from OrthoDB
|
||
</a>
|
||
</ul>
|
||
</div>
|
||
|
||
<!--<component id="Gene_InfoPathway"/>-->
|
||
|
||
|
||
<div class="gene-ontology infosec">
|
||
<h3 id="gene-ontology">
|
||
<a class="jig-ncbitoggler-open">
|
||
<span>Gene Ontology</span>
|
||
</a>
|
||
<a target="_blank" href="http://www.ebi.ac.uk/GOA" class="g-ontology-src" title="Provided by GOA">Provided by GOA</a>
|
||
</h3>
|
||
<div class="ontology-tables">
|
||
<div class="ui-ncbigrid-outer-div">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
|
||
<thead>
|
||
<tr>
|
||
<th class="col1">Function</th>
|
||
<th style="width:12%;">Evidence Code</th>
|
||
<th style="width:10%;">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0042289">enables MHC class II protein binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-1-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/2823150,11535811" target="_blank" title="PubMed ID 2823150,11535811" ref="ordinalpos=1&ncbi_uid=920&link_uid=2823150,11535811">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0042289">enables MHC class II protein binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
|
||
<div id="evidence-code-2-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/24942581" target="_blank" title="PubMed ID 24942581" ref="ordinalpos=1&ncbi_uid=920&link_uid=24942581">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0042289">enables MHC class II protein binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> NAS</a>
|
||
<div id="evidence-code-3-0" class="ecode">Non-traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/8512039" target="_blank" title="PubMed ID 8512039" ref="ordinalpos=1&ncbi_uid=920&link_uid=8512039">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0023026">enables MHC class II protein complex binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-4-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/27114505" target="_blank" title="PubMed ID 27114505" ref="ordinalpos=1&ncbi_uid=920&link_uid=27114505">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0015026">enables coreceptor activity</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> NAS</a>
|
||
<div id="evidence-code-5-0" class="ecode">Non-traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/8512039" target="_blank" title="PubMed ID 8512039" ref="ordinalpos=1&ncbi_uid=920&link_uid=8512039">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0019899">enables enzyme binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
|
||
<div id="evidence-code-6-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/19333378" target="_blank" title="PubMed ID 19333378" ref="ordinalpos=1&ncbi_uid=920&link_uid=19333378">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005201">enables extracellular matrix structural constituent</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> NAS</a>
|
||
<div id="evidence-code-7-0" class="ecode">Non-traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/12444132" target="_blank" title="PubMed ID 12444132" ref="ordinalpos=1&ncbi_uid=920&link_uid=12444132">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0042802">enables identical protein binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
|
||
<div id="evidence-code-8-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/9168119" target="_blank" title="PubMed ID 9168119" ref="ordinalpos=1&ncbi_uid=920&link_uid=9168119">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0042011">enables interleukin-16 binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
|
||
<div id="evidence-code-9-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/24942581" target="_blank" title="PubMed ID 24942581" ref="ordinalpos=1&ncbi_uid=920&link_uid=24942581">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0042012">enables interleukin-16 receptor activity</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-10-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/24942581" target="_blank" title="PubMed ID 24942581" ref="ordinalpos=1&ncbi_uid=920&link_uid=24942581">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0008289">enables lipid binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> EXP</a>
|
||
<div id="evidence-code-11-0" class="ecode">Inferred from Experiment<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/9622505,19781520" target="_blank" title="PubMed ID 9622505,19781520" ref="ordinalpos=1&ncbi_uid=920&link_uid=9622505,19781520">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005515">enables protein binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-12-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
|
||
<div id="evidence-code-12-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/7831289,9168119,10816381,10922058,11113139,11264384,15660419,16888650,17005671,17301785,19333378,20080564,20357769,23890821,26098315,27114505,30542158,32814053" target="_blank" title="PubMed ID 7831289,9168119,10816381,10922058,11113139,11264384,15660419,16888650,17005671,17301785,19333378,20080564,20357769,23890821,26098315,27114505,30542158,32814053" ref="ordinalpos=1&ncbi_uid=920&link_uid=7831289,9168119,10816381,10922058,11113139,11264384,15660419,16888650,17005671,17301785,19333378,20080564,20357769,23890821,26098315,27114505,30542158,32814053">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0042803">enables protein homodimerization activity</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-13-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-13-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/9168119,12444132" target="_blank" title="PubMed ID 9168119,12444132" ref="ordinalpos=1&ncbi_uid=920&link_uid=9168119,12444132">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0019901">enables protein kinase binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-14-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
|
||
<div id="evidence-code-14-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/7486703" target="_blank" title="PubMed ID 7486703" ref="ordinalpos=1&ncbi_uid=920&link_uid=7486703">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:1990782">enables protein tyrosine kinase binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-15-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
|
||
<div id="evidence-code-15-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/3262426" target="_blank" title="PubMed ID 3262426" ref="ordinalpos=1&ncbi_uid=920&link_uid=3262426">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0038023">enables signaling receptor activity</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-16-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-16-0" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/10413516" target="_blank" title="PubMed ID 10413516" ref="ordinalpos=1&ncbi_uid=920&link_uid=10413516">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0004888">enables transmembrane signaling receptor activity</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-17-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-17-0" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/10358157" target="_blank" title="PubMed ID 10358157" ref="ordinalpos=1&ncbi_uid=920&link_uid=10358157">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0001618">enables virus receptor activity</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-18-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-18-0" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0008270">enables zinc ion binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-19-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-19-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/9668045" target="_blank" title="PubMed ID 9668045" ref="ordinalpos=1&ncbi_uid=920&link_uid=9668045">PubMed</a> </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
<div class="ui-ncbigrid-outer-div">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
|
||
<thead>
|
||
<tr>
|
||
<th class="col1">Process</th>
|
||
<th style="width:12%;">Evidence Code</th>
|
||
<th style="width:10%;">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0030217">involved_in T cell differentiation</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-1-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/1533274" target="_blank" title="PubMed ID 1533274" ref="ordinalpos=1&ncbi_uid=920&link_uid=1533274">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0045058">involved_in T cell selection</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-2-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/9551897" target="_blank" title="PubMed ID 9551897" ref="ordinalpos=1&ncbi_uid=920&link_uid=9551897">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0002250">involved_in adaptive immune response</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-3-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0019722">involved_in calcium-mediated signaling</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-4-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0007155">involved_in cell adhesion</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-5-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0007169">involved_in cell surface receptor protein tyrosine kinase signaling pathway</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> NAS</a>
|
||
<div id="evidence-code-6-1" class="ecode">Non-traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/8512039" target="_blank" title="PubMed ID 8512039" ref="ordinalpos=1&ncbi_uid=920&link_uid=8512039">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0007166">involved_in cell surface receptor signaling pathway</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-7-1" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/9780207" target="_blank" title="PubMed ID 9780207" ref="ordinalpos=1&ncbi_uid=920&link_uid=9780207">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0097011">involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-8-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/24942581" target="_blank" title="PubMed ID 24942581" ref="ordinalpos=1&ncbi_uid=920&link_uid=24942581">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0050829">involved_in defense response to Gram-negative bacterium</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-9-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0007167">involved_in enzyme-linked receptor protein signaling pathway</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-10-1" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/10358157" target="_blank" title="PubMed ID 10358157" ref="ordinalpos=1&ncbi_uid=920&link_uid=10358157">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0035397">involved_in helper T cell enhancement of adaptive immune response</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-11-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0006955">involved_in immune response</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-12-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> NAS</a>
|
||
<div id="evidence-code-12-1" class="ecode">Non-traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/8512039" target="_blank" title="PubMed ID 8512039" ref="ordinalpos=1&ncbi_uid=920&link_uid=8512039">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0035723">involved_in interleukin-15-mediated signaling pathway</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-13-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-13-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/24942581" target="_blank" title="PubMed ID 24942581" ref="ordinalpos=1&ncbi_uid=920&link_uid=24942581">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0030225">involved_in macrophage differentiation</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-14-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-14-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/24942581" target="_blank" title="PubMed ID 24942581" ref="ordinalpos=1&ncbi_uid=920&link_uid=24942581">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0032507">acts_upstream_of_or_within maintenance of protein location in cell</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-15-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-15-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/15128768" target="_blank" title="PubMed ID 15128768" ref="ordinalpos=1&ncbi_uid=920&link_uid=15128768">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0045893">involved_in positive regulation of DNA-templated transcription</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-16-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-16-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/24942581" target="_blank" title="PubMed ID 24942581" ref="ordinalpos=1&ncbi_uid=920&link_uid=24942581">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0070374">involved_in positive regulation of ERK1 and ERK2 cascade</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-17-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-17-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/24942581" target="_blank" title="PubMed ID 24942581" ref="ordinalpos=1&ncbi_uid=920&link_uid=24942581">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0043410">involved_in positive regulation of MAPK cascade</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-18-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-18-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/24942581" target="_blank" title="PubMed ID 24942581" ref="ordinalpos=1&ncbi_uid=920&link_uid=24942581">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0050870">involved_in positive regulation of T cell activation</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-19-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-19-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0050850">involved_in positive regulation of calcium-mediated signaling</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-20-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-20-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0043123">involved_in positive regulation of canonical NF-kappaB signal transduction</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-21-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-21-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/24942581" target="_blank" title="PubMed ID 24942581" ref="ordinalpos=1&ncbi_uid=920&link_uid=24942581">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0032743">involved_in positive regulation of interleukin-2 production</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-22-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> NAS</a>
|
||
<div id="evidence-code-22-1" class="ecode">Non-traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/1901411" target="_blank" title="PubMed ID 1901411" ref="ordinalpos=1&ncbi_uid=920&link_uid=1901411">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0033674">involved_in positive regulation of kinase activity</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-23-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-23-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/24942581" target="_blank" title="PubMed ID 24942581" ref="ordinalpos=1&ncbi_uid=920&link_uid=24942581">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0045657">involved_in positive regulation of monocyte differentiation</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-24-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-24-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/24942581" target="_blank" title="PubMed ID 24942581" ref="ordinalpos=1&ncbi_uid=920&link_uid=24942581">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0045860">involved_in positive regulation of protein kinase activity</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-25-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-25-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/2118992" target="_blank" title="PubMed ID 2118992" ref="ordinalpos=1&ncbi_uid=920&link_uid=2118992">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0001934">involved_in positive regulation of protein phosphorylation</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-26-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-26-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/24942581" target="_blank" title="PubMed ID 24942581" ref="ordinalpos=1&ncbi_uid=920&link_uid=24942581">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0046598">involved_in positive regulation of viral entry into host cell</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-27-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-27-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/24942581" target="_blank" title="PubMed ID 24942581" ref="ordinalpos=1&ncbi_uid=920&link_uid=24942581">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0050863">involved_in regulation of T cell activation</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-28-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-28-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/1533274" target="_blank" title="PubMed ID 1533274" ref="ordinalpos=1&ncbi_uid=920&link_uid=1533274">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0051924">involved_in regulation of calcium ion transport</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-29-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-29-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/24942581" target="_blank" title="PubMed ID 24942581" ref="ordinalpos=1&ncbi_uid=920&link_uid=24942581">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0007165">involved_in signal transduction</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-30-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-30-1" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/9558100,10358157" target="_blank" title="PubMed ID 9558100,10358157" ref="ordinalpos=1&ncbi_uid=920&link_uid=9558100,10358157">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0046718">involved_in symbiont entry into host cell</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-31-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-31-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
<div class="ui-ncbigrid-outer-div">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-config="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
|
||
<thead>
|
||
<tr>
|
||
<th class="col1">Component</th>
|
||
<th style="width:12%;">Evidence Code</th>
|
||
<th style="width:10%;">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0042101">part_of T cell receptor complex</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> NAS</a>
|
||
<div id="evidence-code-1-2" class="ecode">Non-traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/8512039" target="_blank" title="PubMed ID 8512039" ref="ordinalpos=1&ncbi_uid=920&link_uid=8512039">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0030669">located_in clathrin-coated endocytic vesicle membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-2-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005769">located_in early endosome</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-3-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005788">located_in endoplasmic reticulum lumen</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-4-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005789">located_in endoplasmic reticulum membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-5-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0009897">located_in external side of plasma membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-6-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/17213291" target="_blank" title="PubMed ID 17213291" ref="ordinalpos=1&ncbi_uid=920&link_uid=17213291">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0045121">located_in membrane raft</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-7-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/9168119" target="_blank" title="PubMed ID 9168119" ref="ordinalpos=1&ncbi_uid=920&link_uid=9168119">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005886">located_in plasma membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-8-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/2823150,8124721,11390434,19333378,24942581" target="_blank" title="PubMed ID 2823150,8124721,11390434,19333378,24942581" ref="ordinalpos=1&ncbi_uid=920&link_uid=2823150,8124721,11390434,19333378,24942581">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005886">located_in plasma membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-9-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-general-protein-info">
|
||
<section class="rprt-section-header" id="general-protein-info">
|
||
<h2 id="header-general-protein-info">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-protein-info .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">General protein information</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.General_Protein_Information" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<dl>
|
||
<dt>Preferred Names</dt>
|
||
<dd>T-cell surface glycoprotein CD4</dd>
|
||
</dl>
|
||
<dl>
|
||
<dt>Names</dt>
|
||
<dd>CD4 antigen (p55)</dd>
|
||
<dd>CD4 receptor</dd>
|
||
<dd>T-cell surface antigen T4/Leu-3</dd>
|
||
</dl>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-reference-sequences">
|
||
<section class="rprt-section-header" id="reference-sequences">
|
||
<h2 id="header-reference-sequences">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-reference-sequences .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">NCBI Reference Sequences (RefSeq)</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.NCBI_Reference_Sequences_RefS" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<p>
|
||
<span class="new-icon">NEW</span>
|
||
<strong>Try the new <a href="/datasets/tables/genes/?table_type=transcripts&ids=920&utm_source=gene&utm_medium=referral&utm_campaign=refseq" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report." data-ga-category="refseq" data-ga-action="click_datasets_link" data-ga-label="transcript_table">Transcript table</a></strong>
|
||
</p>
|
||
<h3 class="genomerefseqs gene_std_toggler" id="refseqset-independent">
|
||
<a class="jig-ncbitoggler-open">RefSeqs maintained independently of Annotated
|
||
Genomes</a>
|
||
</h3>
|
||
<div class="genomerefseqs_slave">
|
||
<p class="desc"> These reference sequences exist independently of genome builds. <a href="#refseq-expl" id="expl-refseg">Explain</a></p>
|
||
<p id="refseq-expl"> These reference sequences are curated independently of the genome
|
||
annotation cycle, so their versions may not match the RefSeq versions in the current
|
||
genome build. Identify version mismatches by comparing the version of the RefSeq in
|
||
this section to the one reported in <a href="#geneGenomic regions, transcripts, and products">Genomic regions,
|
||
transcripts, and products</a> above. </p>
|
||
<h4 id="genomic-p50054288">Genomic </h4>
|
||
<ol>
|
||
<li>
|
||
<p>NG_027688.2 RefSeqGene</p>
|
||
<dl>
|
||
<dt>Range</dt>
|
||
<dd class="rs-range">
|
||
<span>5002..36273</span>
|
||
</dd>
|
||
<dt>Download</dt>
|
||
<dd><a href="/nuccore/NG_027688.2?from=5002&to=36273&report=genbank" ref="ordinalpos=1&ncbi_uid=920&link_uid=NG_027688.2?from=5002&to=36273&report=genbank">GenBank</a>, <a href="/nuccore/NG_027688.2?from=5002&to=36273&report=fasta" ref="ordinalpos=1&ncbi_uid=920&link_uid=NG_027688.2?from=5002&to=36273&report=fasta">FASTA</a>, <a href="/nuccore/NG_027688.2?from=310&to=40963&report=graph&content=5" ref="ordinalpos=1&ncbi_uid=920&link_uid=NG_027688.2?from=310&to=40963&report=graph&content=5">Sequence Viewer (Graphics)</a></dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
<h4 id="mrnaandproteins-p184805168">mRNA and Protein(s) </h4>
|
||
<ol>
|
||
<li>
|
||
<p><a href="/nuccore/NM_000616.5">NM_000616.5</a> → <a href="/protein/NP_000607.1">NP_000607.1</a> T-cell surface glycoprotein CD4 isoform 1 precursor</p>
|
||
<p>
|
||
<a href="/ipg/NP_000607.1/" ref="ncbi_uid=920">See identical proteins and their annotated locations for NP_000607.1</a>
|
||
</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (1) encodes the longest isoform (1) including a signal peptide and a mature peptide.</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AC125494, U47924">AC125494, U47924</a>
|
||
</dd>
|
||
<dt>Consensus CDS</dt>
|
||
<dd>
|
||
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS8562.1">CCDS8562.1</a>
|
||
</dd>
|
||
<dt>UniProtKB/Swiss-Prot</dt>
|
||
<dd><a href="https://www.uniprot.org/uniprot/B2R737" ref="itool=Gene_FullReport&PrId=5380&uid=920&nlmid=&db=gene">B2R737</a>, <a href="https://www.uniprot.org/uniprot/D3DUS5" ref="itool=Gene_FullReport&PrId=5380&uid=920&nlmid=&db=gene">D3DUS5</a>, <a href="https://www.uniprot.org/uniprot/P01730" ref="itool=Gene_FullReport&PrId=5380&uid=920&nlmid=&db=gene">P01730</a>, <a href="https://www.uniprot.org/uniprot/Q4ZGK2" ref="itool=Gene_FullReport&PrId=5380&uid=920&nlmid=&db=gene">Q4ZGK2</a>, <a href="https://www.uniprot.org/uniprot/Q5U066" ref="itool=Gene_FullReport&PrId=5380&uid=920&nlmid=&db=gene">Q5U066</a>, <a href="https://www.uniprot.org/uniprot/Q9UDE5" ref="itool=Gene_FullReport&PrId=5380&uid=920&nlmid=&db=gene">Q9UDE5</a></dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd>
|
||
<a href="https://www.uniprot.org/uniprot/A0A4Y5UGE4" ref="itool=Gene_FullReport&PrId=5380&uid=920&nlmid=&db=gene">A0A4Y5UGE4</a>
|
||
</dd>
|
||
<dt>Related</dt>
|
||
<dd><a href="http://www.ensembl.org/id/ENSP00000011653.4" ref="itool=Gene_FullReport&PrId=5380&uid=920&nlmid=&db=gene">ENSP00000011653.4</a>, <a href="http://www.ensembl.org/id/ENST00000011653.9" ref="itool=Gene_FullReport&PrId=5380&uid=920&nlmid=&db=gene">ENST00000011653.9</a></dd>
|
||
<dt class="clear"> Conserved Domains (5) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_000607.1">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=399065">pfam05790</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">317</span> → <span class="cddto">389</span></dt>
|
||
<dd class="clearfix"> C2-set; Immunoglobulin C2-set domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=401221">pfam09191</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">208</span> → <span class="cddto">316</span></dt>
|
||
<dd class="clearfix"> CD4-extracel; CD4, extracellular</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=409487">cd07690</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">26</span> → <span class="cddto">122</span></dt>
|
||
<dd class="clearfix"> IgV_1_CD4; First immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the V-set of IgSF domains</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=409491">cd07694</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">123</span> → <span class="cddto">204</span></dt>
|
||
<dd class="clearfix"> IgC2_2_CD4; Second immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the C2-set of IgSF domains</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=409492">cd07695</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">219</span> → <span class="cddto">223</span></dt>
|
||
<dd class="clearfix"> IgV_3_CD4; Ig strand B [structural motif]</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_001195014.3">NM_001195014.3</a> → <a href="/protein/NP_001181943.1">NP_001181943.1</a> T-cell surface glycoprotein CD4 isoform 2</p>
|
||
<p>
|
||
<a href="/ipg/NP_001181943.1/" ref="ncbi_uid=920">See identical proteins and their annotated locations for NP_001181943.1</a>
|
||
</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (2) uses an alternate splice site, lacks two consecutive exons and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AC125494, U47924">AC125494, U47924</a>
|
||
</dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd>
|
||
<a href="https://www.uniprot.org/uniprot/B0AZV7" ref="itool=Gene_FullReport&PrId=5380&uid=920&nlmid=&db=gene">B0AZV7</a>
|
||
</dd>
|
||
<dt class="clear"> Conserved Domains (4) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001181943.1">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=213052">cd12087</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">209</span> → <span class="cddto">249</span></dt>
|
||
<dd class="clearfix"> TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=283453">pfam05790</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">138</span> → <span class="cddto">210</span></dt>
|
||
<dd class="clearfix"> C2-set; Immunoglobulin C2-set domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=286300">pfam09191</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">29</span> → <span class="cddto">137</span></dt>
|
||
<dd class="clearfix"> CD4-extracel; CD4, extracellular</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=288921">pfam12104</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">247</span> → <span class="cddto">274</span></dt>
|
||
<dd class="clearfix"> Tcell_CD4_C; T cell CD4 receptor C terminal region</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_001195015.3">NM_001195015.3</a> → <a href="/protein/NP_001181944.1">NP_001181944.1</a> T-cell surface glycoprotein CD4 isoform 3</p>
|
||
<p>
|
||
<a href="/ipg/NP_001181944.1/" ref="ncbi_uid=920">See identical proteins and their annotated locations for NP_001181944.1</a>
|
||
</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (3) uses an alternate splice site, lacks two consecutive exons and initiates translation from a downstream, in-frame start codon, compared to variant 1. Variants 3, 4 and 5 encode isoform 3, which has a shorter N-terminus, compared to isoform 1.</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AC125494, U47924">AC125494, U47924</a>
|
||
</dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd><a href="https://www.uniprot.org/uniprot/B4DT49" ref="itool=Gene_FullReport&PrId=5380&uid=920&nlmid=&db=gene">B4DT49</a>, <a href="https://www.uniprot.org/uniprot/B4E1T0" ref="itool=Gene_FullReport&PrId=5380&uid=920&nlmid=&db=gene">B4E1T0</a></dd>
|
||
<dt class="clear"> Conserved Domains (3) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001181944.1">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=399065">pfam05790</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">44</span> → <span class="cddto">116</span></dt>
|
||
<dd class="clearfix"> C2-set; Immunoglobulin C2-set domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=409353">cd00096</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">7</span> → <span class="cddto">12</span></dt>
|
||
<dd class="clearfix"> Ig; Ig strand E [structural motif]</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=416386">cl11960</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1</span> → <span class="cddto">43</span></dt>
|
||
<dd class="clearfix"> Ig; Immunoglobulin domain</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_001195016.3">NM_001195016.3</a> → <a href="/protein/NP_001181945.1">NP_001181945.1</a> T-cell surface glycoprotein CD4 isoform 3</p>
|
||
<p>
|
||
<a href="/ipg/NP_001181945.1/" ref="ncbi_uid=920">See identical proteins and their annotated locations for NP_001181945.1</a>
|
||
</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (4) lacks two consecutive exons and initiates translation from a downstream, in-frame start codon, compared to variant 1. Variants 3, 4 and 5 encode isoform 3, which has a shorter N-terminus, compared to isoform 1.</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AC125494, U47924">AC125494, U47924</a>
|
||
</dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd><a href="https://www.uniprot.org/uniprot/B4DT49" ref="itool=Gene_FullReport&PrId=5380&uid=920&nlmid=&db=gene">B4DT49</a>, <a href="https://www.uniprot.org/uniprot/B4E1T0" ref="itool=Gene_FullReport&PrId=5380&uid=920&nlmid=&db=gene">B4E1T0</a></dd>
|
||
<dt class="clear"> Conserved Domains (3) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001181945.1">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=399065">pfam05790</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">44</span> → <span class="cddto">116</span></dt>
|
||
<dd class="clearfix"> C2-set; Immunoglobulin C2-set domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=409353">cd00096</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">7</span> → <span class="cddto">12</span></dt>
|
||
<dd class="clearfix"> Ig; Ig strand E [structural motif]</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=416386">cl11960</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1</span> → <span class="cddto">43</span></dt>
|
||
<dd class="clearfix"> Ig; Immunoglobulin domain</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_001195017.3">NM_001195017.3</a> → <a href="/protein/NP_001181946.1">NP_001181946.1</a> T-cell surface glycoprotein CD4 isoform 3</p>
|
||
<p>
|
||
<a href="/ipg/NP_001181946.1/" ref="ncbi_uid=920">See identical proteins and their annotated locations for NP_001181946.1</a>
|
||
</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (5) uses an alternate splice site, lacks two consecutive exons and initiates translation from a downstream, in-frame start codon, compared to variant 1. Variants 3, 4 and 5 encode isoform 3, which has a shorter N-terminus, compared to isoform 1.</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AC125494, U47924">AC125494, U47924</a>
|
||
</dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd><a href="https://www.uniprot.org/uniprot/B4DT49" ref="itool=Gene_FullReport&PrId=5380&uid=920&nlmid=&db=gene">B4DT49</a>, <a href="https://www.uniprot.org/uniprot/B4E1T0" ref="itool=Gene_FullReport&PrId=5380&uid=920&nlmid=&db=gene">B4E1T0</a></dd>
|
||
<dt class="clear"> Conserved Domains (3) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001181946.1">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=399065">pfam05790</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">44</span> → <span class="cddto">116</span></dt>
|
||
<dd class="clearfix"> C2-set; Immunoglobulin C2-set domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=409353">cd00096</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">7</span> → <span class="cddto">12</span></dt>
|
||
<dd class="clearfix"> Ig; Ig strand E [structural motif]</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=416386">cl11960</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1</span> → <span class="cddto">43</span></dt>
|
||
<dd class="clearfix"> Ig; Immunoglobulin domain</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_001382705.1">NM_001382705.1</a> → <a href="/protein/NP_001369634.1">NP_001369634.1</a> T-cell surface glycoprotein CD4 isoform 3</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AC125494, U47924">AC125494, U47924</a>
|
||
</dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd><a href="https://www.uniprot.org/uniprot/B4DT49" ref="itool=Gene_FullReport&PrId=5380&uid=920&nlmid=&db=gene">B4DT49</a>, <a href="https://www.uniprot.org/uniprot/B4E1T0" ref="itool=Gene_FullReport&PrId=5380&uid=920&nlmid=&db=gene">B4E1T0</a></dd>
|
||
<dt class="clear"> Conserved Domains (3) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001369634.1">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=399065">pfam05790</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">44</span> → <span class="cddto">116</span></dt>
|
||
<dd class="clearfix"> C2-set; Immunoglobulin C2-set domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=409353">cd00096</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">7</span> → <span class="cddto">12</span></dt>
|
||
<dd class="clearfix"> Ig; Ig strand E [structural motif]</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=416386">cl11960</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1</span> → <span class="cddto">43</span></dt>
|
||
<dd class="clearfix"> Ig; Immunoglobulin domain</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_001382706.1">NM_001382706.1</a> → <a href="/protein/NP_001369635.1">NP_001369635.1</a> T-cell surface glycoprotein CD4 isoform 3</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AC125494, U47924">AC125494, U47924</a>
|
||
</dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd><a href="https://www.uniprot.org/uniprot/B4DT49" ref="itool=Gene_FullReport&PrId=5380&uid=920&nlmid=&db=gene">B4DT49</a>, <a href="https://www.uniprot.org/uniprot/B4E1T0" ref="itool=Gene_FullReport&PrId=5380&uid=920&nlmid=&db=gene">B4E1T0</a></dd>
|
||
<dt class="clear"> Conserved Domains (3) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001369635.1">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=399065">pfam05790</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">44</span> → <span class="cddto">116</span></dt>
|
||
<dd class="clearfix"> C2-set; Immunoglobulin C2-set domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=409353">cd00096</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">7</span> → <span class="cddto">12</span></dt>
|
||
<dd class="clearfix"> Ig; Ig strand E [structural motif]</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=416386">cl11960</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1</span> → <span class="cddto">43</span></dt>
|
||
<dd class="clearfix"> Ig; Immunoglobulin domain</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_001382707.1">NM_001382707.1</a> → <a href="/protein/NP_001369636.1">NP_001369636.1</a> T-cell surface glycoprotein CD4 isoform 1 precursor</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AC125494, U47924">AC125494, U47924</a>
|
||
</dd>
|
||
<dt>Consensus CDS</dt>
|
||
<dd>
|
||
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS8562.1">CCDS8562.1</a>
|
||
</dd>
|
||
<dt>UniProtKB/Swiss-Prot</dt>
|
||
<dd><a href="https://www.uniprot.org/uniprot/B2R737" ref="itool=Gene_FullReport&PrId=5380&uid=920&nlmid=&db=gene">B2R737</a>, <a href="https://www.uniprot.org/uniprot/D3DUS5" ref="itool=Gene_FullReport&PrId=5380&uid=920&nlmid=&db=gene">D3DUS5</a>, <a href="https://www.uniprot.org/uniprot/P01730" ref="itool=Gene_FullReport&PrId=5380&uid=920&nlmid=&db=gene">P01730</a>, <a href="https://www.uniprot.org/uniprot/Q4ZGK2" ref="itool=Gene_FullReport&PrId=5380&uid=920&nlmid=&db=gene">Q4ZGK2</a>, <a href="https://www.uniprot.org/uniprot/Q5U066" ref="itool=Gene_FullReport&PrId=5380&uid=920&nlmid=&db=gene">Q5U066</a>, <a href="https://www.uniprot.org/uniprot/Q9UDE5" ref="itool=Gene_FullReport&PrId=5380&uid=920&nlmid=&db=gene">Q9UDE5</a></dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd>
|
||
<a href="https://www.uniprot.org/uniprot/A0A4Y5UGE4" ref="itool=Gene_FullReport&PrId=5380&uid=920&nlmid=&db=gene">A0A4Y5UGE4</a>
|
||
</dd>
|
||
<dt class="clear"> Conserved Domains (5) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001369636.1">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=399065">pfam05790</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">317</span> → <span class="cddto">389</span></dt>
|
||
<dd class="clearfix"> C2-set; Immunoglobulin C2-set domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=401221">pfam09191</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">208</span> → <span class="cddto">316</span></dt>
|
||
<dd class="clearfix"> CD4-extracel; CD4, extracellular</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=409487">cd07690</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">26</span> → <span class="cddto">122</span></dt>
|
||
<dd class="clearfix"> IgV_1_CD4; First immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the V-set of IgSF domains</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=409491">cd07694</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">123</span> → <span class="cddto">204</span></dt>
|
||
<dd class="clearfix"> IgC2_2_CD4; Second immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the C2-set of IgSF domains</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=409492">cd07695</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">219</span> → <span class="cddto">223</span></dt>
|
||
<dd class="clearfix"> IgV_3_CD4; Ig strand B [structural motif]</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_001382714.1">NM_001382714.1</a> → <a href="/protein/NP_001369643.1">NP_001369643.1</a> T-cell surface glycoprotein CD4 isoform 4</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AC125494, U47924">AC125494, U47924</a>
|
||
</dd>
|
||
<dt class="clear"> Conserved Domains (7) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001369643.1">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=213052">cd12087</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">333</span> → <span class="cddto">373</span></dt>
|
||
<dd class="clearfix"> TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=399065">pfam05790</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">262</span> → <span class="cddto">334</span></dt>
|
||
<dd class="clearfix"> C2-set; Immunoglobulin C2-set domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=401221">pfam09191</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">153</span> → <span class="cddto">261</span></dt>
|
||
<dd class="clearfix"> CD4-extracel; CD4, extracellular</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=409353">cd00096</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">14</span> → <span class="cddto">17</span></dt>
|
||
<dd class="clearfix"> Ig; Ig strand C" [structural motif]</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=409491">cd07694</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">68</span> → <span class="cddto">149</span></dt>
|
||
<dd class="clearfix"> IgC2_2_CD4; Second immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the C2-set of IgSF domains</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=409492">cd07695</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">164</span> → <span class="cddto">168</span></dt>
|
||
<dd class="clearfix"> IgV_3_CD4; Ig strand B [structural motif]</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=416386">cl11960</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">14</span> → <span class="cddto">67</span></dt>
|
||
<dd class="clearfix"> Ig; Immunoglobulin domain</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
</div>
|
||
<h3 class="genomerefseqs gene_std_toggler" id="annotatedrefseq-title">
|
||
<a class="jig-ncbitoggler-open">RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08</a>
|
||
</h3>
|
||
<div class="genomerefseqs_slave">
|
||
<p class="desc"> The following sections contain reference sequences that belong to a
|
||
specific genome build. <a href="#" id="expl-genomes">Explain</a></p>
|
||
<p id="expl-genomes-desc" style="display:none">This section includes genomic Reference
|
||
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
|
||
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
|
||
assemblies. Model RNAs and proteins are also reported here.</p>
|
||
<h3 id="refseq-sequencedescription-p184975184">Reference GRCh38.p14 Primary Assembly</h3>
|
||
<h4 id="genomic-p184975184">Genomic </h4>
|
||
<ol>
|
||
<li>
|
||
<p>NC_000012.12 Reference GRCh38.p14 Primary Assembly</p>
|
||
<dl>
|
||
<dt>Range</dt>
|
||
<dd class="rs-range">
|
||
<span>6789528..6820799</span>
|
||
</dd>
|
||
<dt>Download</dt>
|
||
<dd><a href="/nuccore/NC_000012.12?from=6789528&to=6820799&report=genbank" ref="ordinalpos=1&ncbi_uid=920&link_uid=NC_000012.12?from=6789528&to=6820799&report=genbank">GenBank</a>, <a href="/nuccore/NC_000012.12?from=6789528&to=6820799&report=fasta" ref="ordinalpos=1&ncbi_uid=920&link_uid=NC_000012.12?from=6789528&to=6820799&report=fasta">FASTA</a>, <a href="/nuccore/NC_000012.12?from=6784836&to=6825489&report=graph&content=5" ref="ordinalpos=1&ncbi_uid=920&link_uid=NC_000012.12?from=6784836&to=6825489&report=graph&content=5">Sequence Viewer (Graphics)</a></dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
<h3 id="refseq-sequencedescription-p128859520">Alternate T2T-CHM13v2.0</h3>
|
||
<h4 id="genomic-p128859520">Genomic </h4>
|
||
<ol>
|
||
<li>
|
||
<p>NC_060936.1 Alternate T2T-CHM13v2.0</p>
|
||
<dl>
|
||
<dt>Range</dt>
|
||
<dd class="rs-range">
|
||
<span>6799096..6830079</span>
|
||
</dd>
|
||
<dt>Download</dt>
|
||
<dd><a href="/nuccore/NC_060936.1?from=6799096&to=6830079&report=genbank" ref="ordinalpos=1&ncbi_uid=920&link_uid=NC_060936.1?from=6799096&to=6830079&report=genbank">GenBank</a>, <a href="/nuccore/NC_060936.1?from=6799096&to=6830079&report=fasta" ref="ordinalpos=1&ncbi_uid=920&link_uid=NC_060936.1?from=6799096&to=6830079&report=fasta">FASTA</a>, <a href="/nuccore/NC_060936.1?from=6794448&to=6834725&report=graph&content=5" ref="ordinalpos=1&ncbi_uid=920&link_uid=NC_060936.1?from=6794448&to=6834725&report=graph&content=5">Sequence Viewer (Graphics)</a></dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
</div>
|
||
<h3 class="genomerefseqs gene_std_toggler">
|
||
<a class="jig-ncbitoggler">Suppressed Reference Sequence(s)</a>
|
||
</h3>
|
||
<div class="genomerefseqs_slave">
|
||
<p class="desc"> The following Reference Sequences have been suppressed. <a href="#expl-suppressed-desc" id="expl-suppressed">Explain</a></p>
|
||
<p id="expl-suppressed-desc" style="display:none">These RefSeqs were suppressed for the
|
||
cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related
|
||
sequence links, or BLAST links (BLink), but may still be retrieved by clicking on
|
||
their accession.version below.</p>
|
||
<ol>
|
||
<li>
|
||
<p><a href="/nuccore/303522653">NR_036545.1</a>: Suppressed sequence</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>NR_036545.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.</dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-related-sequences">
|
||
<section class="rprt-section-header" id="related-sequences">
|
||
<h2 id="header-related-sequences">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-related-sequences .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Related sequences</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Related_Sequences" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div>
|
||
<table id="proteinTblId" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/920/data/related-sequences/',webserviceParams: 'p$l=Ajax', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
|
||
<thead>
|
||
<tr>
|
||
<th colspan="2" id="rs-nucleo">Nucleotide</th>
|
||
<th rowspan="2" id="rs-protein">Protein</th>
|
||
</tr>
|
||
<tr>
|
||
<th id="rs-heading">Heading</th>
|
||
<th id="rs-heading-acc">Accession and Version</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody></tbody>
|
||
</table>
|
||
<table id="proteinTblId" class="jig-ncbigrid" data-jigconfig="isPageable:true, pageSize:25">
|
||
<thead>
|
||
<tr>
|
||
<th class="proteinTblTh" rowspan="2" id="rs-prot-acc">Protein Accession</th>
|
||
<th class="proteinTblTh" colspan="2" id="rs-link">Links</th>
|
||
</tr>
|
||
<tr>
|
||
<th id="rs-genepept">GenPept Link</th>
|
||
<th id="rs-uniprot">UniProtKB Link</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="rs-prot-acc">P01730.1</td>
|
||
<td headers="rs-link rs-genepept">
|
||
<a href="/protein/116013" ref="ordinalpos=1&ncbi_uid=920&link_uid=116013">GenPept</a>
|
||
</td>
|
||
<td>
|
||
<a href="https://www.uniprot.org/uniprot/P01730">UniProtKB/Swiss-Prot:P01730</a>
|
||
</td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-additional-links">
|
||
|
||
<section class="rprt-section-header" id="additional-links"><h2 id="header-additional-links"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-additional-links .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Additional links</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Additional_Links" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
|
||
|
||
<div class="rprt-section-body" style="">
|
||
<div id="lsdb"><h3 class="withnote" id="locusspecificdatabases"><a class="jig-ncbitoggler-open">Locus-specific Databases</a></h3><div><ul class="locusdb"><li><a href="http://databases.lovd.nl/shared/genes/CD4" ref="from_uid=920" class="lsdblink">CD4 database</a></li></ul></div></div>
|
||
|
||
<h3 class="withnote" id="genelinkout">
|
||
<a class="jig-ncbitoggler">Gene LinkOut</a>
|
||
</h3><div>
|
||
<p>The following <a href="https://www.ncbi.nlm.nih.gov/projects/linkout/index.html">LinkOut</a> resources are supplied by external providers. These providers are responsible for maintaining the links. </p>
|
||
<div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Other Literature Sources</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>Dryad Digital Repository</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://datadryad.org/stash/dataset/doi:10.5061/dryad.66h5g23t" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=7893">
|
||
<span>Dryad Digital Repository</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Chemical Information</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>Interologous Interaction Database</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://ophid.utoronto.ca/redirect/ncbi/human?proteins=920" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=7911">
|
||
<span>Interologous Interaction Database</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>MilliporeSigma</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.sigmaaldrich.com/catalog/genes/CD4?lang=en&region=US" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=9978">
|
||
<span>Cd4 products</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Molecular Biology Databases</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>Bgee database</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.bgee.org/gene/ENSG00000010610" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=10418">
|
||
<span>CD4 gene expression</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>BioGPS</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://biogps.org/gene/920/" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=5059">
|
||
<span>BioGPS</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>BioGRID Open Repository of CRISPR Screens (ORCS)</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://orcs.thebiogrid.org/Gene/920" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=10164">
|
||
<span>BioGRID CRISPR Screen Phenotypes (31 hits/1365 screens)</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>Domain Mapping of Disease Mutations</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://bioinf.umbc.edu/DMDM/gene_prot_page.php?id=920" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=7642">
|
||
<span>CD4</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>Eukaryotic Promoter Database</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://epd.vital-it.ch/cgi-bin/get_doc?db=hgEpdNew&format=genome&entry=CD4_1" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=9624">
|
||
<span>CD4_1</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>GlyGen glycoinformatics resource</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://glygen.org/protein/P01730" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=10227">
|
||
<span>GlyGen glycoinformatics resource</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>Guide to Pharmacology</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2995" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=8191">
|
||
<span>CD4 gene</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>Human eFP Browser</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Nervous&modeInput=Absolute&primaryGene=920" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=8875">
|
||
<span>Human eFP Browser</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Skeletal_Immune_Digestive&modeInput=Absolute&primaryGene=920" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=8875">
|
||
<span>Human eFP Browser</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Circulatory_Respiratory&modeInput=Absolute&primaryGene=920" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=8875">
|
||
<span>Human eFP Browser</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li>Ingenuity Pathways Analysis</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://partnersolution.ingenuity.com/?cid=97ae3f91eab87a&p1=Entrez&p2=GV&s=&ipaUri=%2Fpa%2Fapi%2Fv2%2Fgeneview%3Fapplicationname%3DEntrez%26geneId%3D920%26geneidtype%3Dentrezgene" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=5628">
|
||
<span>Ingenuity Pathways Analysis</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>InnateDB</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://www.innatedb.com/getGeneCard.do?id=15034" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=7894">
|
||
<span>InnateDB</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>InterMine</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.humanmine.org/humanmine/search?keyword=ENSG00000010610" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=9169">
|
||
<span>InterMine</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>Kyoto Encyclopedia of Genes and Genomes</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://www.genome.jp/dbget-bin/www_bget?hsa:920" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=5174">
|
||
<span>Kyoto Encyclopedia of Genes and Genomes</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>OMA Browser: Orthologous MAtrix</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN10779/" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=9822">
|
||
<span>OMA Browser: Orthologous MAtrix</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>OrthoDB catalog of orthologs</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.orthodb.org/?ncbi=920" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=8178">
|
||
<span>Orthologs</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>Pharmacogenomics Knowledge Base</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.pharmgkb.org/gene/PA26220" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=4067">
|
||
<span>Annotated Pharmacogenomic Information for CD4 [PharmGKB]</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>PhosphoSitePlus</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.phosphosite.org/entrezGeneIdAction.action?id=920" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=7987">
|
||
<span>PhosphoSitePlus® - comprehensive post-translational modification resource</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>The Gene Wiki</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://en.wikipedia.org/wiki/CD4" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=6933">
|
||
<span>The Gene Wiki</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>The Weizmann Institute of Science GeneCards and MalaCards databases</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=CD4" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=8598">
|
||
<span>GeneCard for CD4</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Research Materials</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="order-rsc"></span>Addgene Non-profit plasmid repository</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://addgene.org//browse/gene/920" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=5304">
|
||
<span>Get Plasmids - Addgene</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>Bio-Techne</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.bio-techne.com/t/cd4/proteins-enzymes?utm_source=linkout&utm_medium=referral&utm_campaign=product&utm_term=proteins" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=8242">
|
||
<span>CD4 Proteins</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.bio-techne.com/t/cd4/antibodies?utm_source=linkout&utm_medium=referral&utm_campaign=product&utm_term=antibodies" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=8242">
|
||
<span>CD4 Antibodies</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.bio-techne.com/t/cd4/elisa-kits?utm_source=linkout&utm_medium=referral&utm_campaign=product&utm_term=elisakits" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=8242">
|
||
<span>CD4 ELISA Kits</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>Creative Biogene</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.creative-biogene.com/genesearch/Cd4.html" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=10094">
|
||
<span>CD4 molecule</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li>ExactAntigen/Labome</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.labome.com/review/gene/human/CD4-antibody.html" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=5753">
|
||
<span>reagent review</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.labome.com/gene/human/CD4-antibody.html" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=5753">
|
||
<span>reagents</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>GenScript latest version of gene cDNA ORF Clone</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://www.genscript.com/gene/920" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=8012">
|
||
<span>GenScript latest version of gene cDNA ORF Clone</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>GeneCopoeia Inc.</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=26&field=5&key=920" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=7255">
|
||
<span>Order TALEN/CRISPR clones</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?tax_id=9606&field=5&prt=16&key=920" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=7255">
|
||
<span>Order miRNA target clones</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=1&field=5&key=920" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=7255">
|
||
<span>Order full-length ORF clone</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>GeneTex Inc</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.genetex.com/Product/Search?geneid=920&type=01&page=1" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=8117">
|
||
<span>Find Quality Antibodies</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.genetex.com/Product/Search?geneid=920&type=03&page=1" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=8117">
|
||
<span>Find Recombinant Proteins and Peptides</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>Kazusa DNA Research Institute</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://www.kazusa.or.jp/kop/dsearch/symsearch.cgi?keyword=CD4;" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=3267">
|
||
<span>Kazusa DNA Research Institute</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>OriGene</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.origene.com/search?q=CD4" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=7994">
|
||
<span>Order CD4 cDNA clone/Protein/Antibody/RNAi</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Tools</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>GeneMANIA</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://genemania.org/link?o=9606&g=920" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=7529">
|
||
<span>GeneMANIA</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open">
|
||
<span>Miscellaneous</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>Reactome</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://reactome.org/PathwayBrowser/#/R-HSA-1643685" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=4914">
|
||
<span>Reactome Event:Disease</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://reactome.org/PathwayBrowser/#/R-HSA-168256" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=4914">
|
||
<span>Reactome Event:Immune System</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://reactome.org/PathwayBrowser/#/R-HSA-5653656" ref="itool=Gene_FullReport&uid=920&nlmid=&db=gene&log$=linkoutlink&PrId=4914">
|
||
<span>Reactome Event:Vesicle-mediated transport</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="urls-in-genombrowser" style="display:none">
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div><input type="hidden" class="section_status_input" name="status_checked" id="status_checked" value="" /><input type="hidden" class="section_status_input" name="status_open" id="status_open" value="summary,region,context,bibliography,phenotypes,variation,hiv,interactions,pathways,geneInfo,proteinInfo,refSeq,related,links" /><input type="hidden" class="section_status_input" name="status_exist" id="status_exist" value="summary,context,region,expression,bibliography,phenotypes,variation,hiv,,interactions,geneInfo,proteinInfo,refSeq,related,links" /><input type="hidden" class="section_status_input" name="status_closed" id="status_closed" value="" /><meta name="status_checked" content="" class="meta_section_status" /><meta name="status_open" content="summary,region,context,bibliography,phenotypes,variation,hiv,interactions,pathways,geneInfo,proteinInfo,refSeq,related,links" class="meta_section_status" /><meta name="status_exist" content="summary,context,region,expression,bibliography,phenotypes,variation,hiv,,interactions,geneInfo,proteinInfo,refSeq,related,links" class="meta_section_status" /><meta name="status_closed" content="" class="meta_section_status" /><script type="text/javascript">
|
||
|
||
var section_status_meta = {
|
||
'status_checked': '',
|
||
'status_open': 'summary,region,context,bibliography,phenotypes,variation,hiv,interactions,pathways,geneInfo,proteinInfo,refSeq,related,links',
|
||
'status_exist': 'summary,context,region,expression,bibliography,phenotypes,variation,hiv,,interactions,geneInfo,proteinInfo,refSeq,related,links',
|
||
'status_closed': ''
|
||
};
|
||
|
||
|
||
/*
|
||
for (var o in section_status_meta) {
|
||
var meta=document.createElement('meta');
|
||
meta.name = o;
|
||
meta.content = section_status_meta[o];
|
||
var attr = document.createAttribute('data-ignore-limit');
|
||
attr.value = 'true';
|
||
meta.setAttributeNode(attr);
|
||
document.getElementsByTagName('head')[0].appendChild(meta);
|
||
}
|
||
*/
|
||
|
||
|
||
var __ncbi_sg_pingCallbacks_render_gene = function (data, evtObj, type) {
|
||
// data looks like {jsevent: "click", "link_id": "foo", ...}
|
||
// evtObj is the JS event object
|
||
// type is either "stat" (for applog) or "ga"
|
||
var extraData = {};
|
||
if (type == "stat") {
|
||
for (var o in section_status_meta) {
|
||
extraData[o] = section_status_meta[o];
|
||
}
|
||
|
||
return extraData;
|
||
|
||
}
|
||
}
|
||
|
||
|
||
</script></div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last" id="sidebar_tabular">
|
||
<!-- sidebar close/hide button-->
|
||
<div class="ui-helper-clearfix">
|
||
<a href="#" id="sidecontent_2_pullout" style="float:right;" class="sidecontentpullout_local collapse_button"><span>Hide sidebar >></span></a>
|
||
</div>
|
||
<!-- end sidebar close/hide button-->
|
||
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div id="gene-sidebar">
|
||
<div>
|
||
<div class="portlet brieflink dis-table-of-contents">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Table of contents</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_TableOfContents" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li class="">
|
||
<a href="#summary">Summary</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#genomic-context">Genomic context</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#genomic-regions-transcripts-products">Genomic regions, transcripts, and products</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#gene-expression">Expression</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#bibliography">Bibliography</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#phenotypes">Phenotypes</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#variation">Variation</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#HIV-1-interactions">HIV-1 interactions</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#pathways">Pathways from PubChem</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#interactions">Interactions</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#general-gene-info">General gene information</a>
|
||
<div class="subsection-links"><a href="#gene-markers">Markers</a>, <a href="#homology">Homology</a>, <a href="#gene-ontology">Gene Ontology</a></div>
|
||
</li>
|
||
<li class="">
|
||
<a href="#general-protein-info">General protein information</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#reference-sequences">NCBI Reference Sequences (RefSeq)</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#related-sequences">Related sequences</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#additional-links">Additional links</a>
|
||
<div class="subsection-links">
|
||
<a href="#lsdb">Locus-specific Databases</a>
|
||
</div>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-genomesbrowser brieflink dis-genomesbrowser">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Genome Browsers</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GenomeBrowsers.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GenomeBrowsers" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GenomeBrowsers.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="#">Loading...</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet dis-related-info brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content DiscoveryDbLinks">
|
||
<ul>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clone/order/gene/920" ref="log$=recordlinks">Order cDNA clone</a>
|
||
<div class="brieflinkpop offscreen_noflow">Order cDNA clone</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/structure?LinkName=gene_structure&from_uid=920" ref="log$=recordlinks">3D structures</a>
|
||
<div class="brieflinkpop offscreen_noflow">3D structure of a gene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_alltarget_list&from_uid=920" ref="log$=recordlinks">BioAssay by Target (List)</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioAssays related to the gene by protein target or RNAi target</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="//pubchem.ncbi.nlm.nih.gov/assay/bioactivity.html?geneid=920" ref="log$=recordlinks">BioAssay by Target (Summary)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Summarized PubChem Data on the gene, showing the active data by default</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_target&from_uid=920" ref="log$=recordlinks">BioAssay, by Gene target</a>
|
||
<div class="brieflinkpop offscreen_noflow">PubChem BioAssays done on the Gene target</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai&from_uid=920" ref="log$=recordlinks">BioAssays, RNAi Target, Tested</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/bioproject?LinkName=gene_bioproject&from_uid=920" ref="log$=recordlinks">BioProjects</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioProjects related to a gene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/biosystems?LinkName=gene_biosystems&from_uid=920" ref="log$=recordlinks">BioSystems</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioSystems</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/books?LinkName=gene_books&from_uid=920" ref="log$=recordlinks">Books</a>
|
||
<div class="brieflinkpop offscreen_noflow">Books</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/CCDS/CcdsBrowse.cgi?REQUEST=GENEID&DATA=920" ref="log$=recordlinks">CCDS</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to CCDS</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar&from_uid=920" ref="log$=recordlinks">ClinVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/cdd?LinkName=gene_cdd&from_uid=920" ref="log$=recordlinks">Conserved Domains</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related CDD</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/dbvar?LinkName=gene_dbvar&from_uid=920" ref="log$=recordlinks">dbVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link from Gene to dbVar</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc&from_uid=920" ref="log$=recordlinks">Full text in PMC</a>
|
||
<div class="brieflinkpop offscreen_noflow">PMC links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc_nucleotide&from_uid=920" ref="log$=recordlinks">Full text in PMC_nucleotide</a>
|
||
<div class="brieflinkpop offscreen_noflow">Full text in PubMedCentral identified from shared sequence links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gap?LinkName=gene_gap&from_uid=920" ref="log$=recordlinks">GAP</a>
|
||
<div class="brieflinkpop offscreen_noflow">GAP Links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gene?LinkName=gene_gene_neighbors&from_uid=920" ref="log$=recordlinks">Gene neighbors</a>
|
||
<div class="brieflinkpop offscreen_noflow">Overlapping genes and two nearest non-overlapping genes on either side</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/genome?LinkName=gene_genome&from_uid=920" ref="log$=recordlinks">Genome</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related Genome</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/geoprofiles?LinkName=gene_geoprofiles&from_uid=920" ref="log$=recordlinks">GEO Profiles</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related GEO</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests/?term=920[geneid]" ref="log$=recordlinks">GTR</a>
|
||
<div class="brieflinkpop offscreen_noflow">Tests for this gene in the NIH Genetic Testing Registry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/homologene?LinkName=gene_homologene&from_uid=920" ref="log$=recordlinks">HomoloGene</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related HomoloGene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/medgen?LinkName=gene_medgen_diseases&from_uid=920" ref="log$=recordlinks">MedGen</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in MedGen</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore&from_uid=920" ref="log$=recordlinks">Nucleotide</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related Nucleotide entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/omim?LinkName=gene_omim&from_uid=920" ref="log$=recordlinks">OMIM</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related OMIM entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/probe?LinkName=gene_probe&from_uid=920" ref="log$=recordlinks">Probe</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related Probe entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein&from_uid=920" ref="log$=recordlinks">Protein</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related protein entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pccompound?LinkName=gene_pccompound&from_uid=920" ref="log$=recordlinks">PubChem Compound</a>
|
||
<div class="brieflinkpop offscreen_noflow">PubChem Compounds</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcsubstance?LinkName=gene_pcsubstance&from_uid=920" ref="log$=recordlinks">PubChem Substance</a>
|
||
<div class="brieflinkpop offscreen_noflow">PubChem Substances</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed&from_uid=920" ref="log$=recordlinks">PubMed</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related PubMed entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_rif&from_uid=920" ref="log$=recordlinks">PubMed (GeneRIF)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related PubMed article from GeneRIFs</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_citedinomim&from_uid=920" ref="log$=recordlinks">PubMed (OMIM)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Gene links to PubMed derived from omim_pubmed_cited links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_pmc_nucleotide&from_uid=920" ref="log$=recordlinks">PubMed(nucleotide/PMC)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Citations in PubMed identified from shared sequence and PMC links.</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein_refseq&from_uid=920" ref="log$=recordlinks">RefSeq Proteins</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to Protein RefSeqs</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore_refseqrna&from_uid=920" ref="log$=recordlinks">RefSeq RNAs</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to Nucleotide RefSeq RNAs</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/nuccore/2302519964?report=graph" ref="log$=recordlinks">RefSeqGene</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to Nucleotide RefSeqGenes</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/snp?LinkName=gene_snp&from_uid=920" ref="log$=recordlinks">SNP</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related SNP records</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/taxonomy?LinkName=gene_taxonomy&from_uid=920" ref="log$=recordlinks">Taxonomy</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related taxonomy entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/variation/view/?q=920[geneid]" ref="log$=recordlinks">Variation Viewer</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related Variants</div>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet dis-links-to-other-res brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Links to other resources</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_LinksTwo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1678">HGNC</a>
|
||
</li>
|
||
<li>
|
||
<a href="http://www.ensembl.org/id/ENSG00000010610">Ensembl</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.alliancegenome.org/gene/HGNC:1678">AllianceGenome</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=geneid&org=9606&l=920">AceView</a>
|
||
</li>
|
||
<li>
|
||
<a href="http://databases.lovd.nl/shared/genes/CD4">CD4 database</a>
|
||
</li>
|
||
<li>
|
||
<a href="http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_001382706">UCSC</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://genecollections.nci.nih.gov/MGC/?ORG=Hs&LIST=BC025782">MGC</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://phgkb.cdc.gov/PHGKB/huGEPedia.action?firstQuery=CD4&geneID=920&typeOption=gene&which=2&pubOrderType=pubD&typeSubmit=GO&check=y">HuGE Navigator</a>
|
||
</li>
|
||
<li>
|
||
<a href="http://www.genome.jp/dbget-bin/www_bget?hsa:920">KEGG</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-general-info">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>General information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GeneralInfo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="/pmc/?term=PMC4383897+OR+PMC3013746+OR+PMC1761442+OR+PMC539985">About Gene</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK3840">FAQ</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://ftp.ncbi.nlm.nih.gov/gene/">FTP site</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK3841/">Help</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK3842/">My NCBI help</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK21085/">NCBI Handbook</a>
|
||
</li>
|
||
<li>
|
||
<a href="/gene/statistics/">Statistics</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-related-sites">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related sites</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_RelatedSites" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/BLAST">BLAST</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/genome">Genome</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/bioproject">BioProject</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/genome/gdv/">Genome Data Viewer</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/geo">GEO</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/omim">OMIM</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/probe">Probe</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/RefSeq">RefSeq</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-feedback">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
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<h3>Feedback</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_Feedback" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
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<ul>
|
||
<li>
|
||
<a href="https://support.ncbi.nlm.nih.gov/ics/support/ticketnewwizard.asp?style=classic&deptID=28049">Contact Help Desk</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/RefSeq/update.cgi?geneid=920&symbol=CD4">Submit Correction</a>
|
||
</li>
|
||
<li>
|
||
<a href="/gene/submit-generif?geneId=920&sym=CD4&name=CD4 molecule&org=Homo sapiens">Submit GeneRIF</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-subscription">
|
||
<div class="portlet_head">
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<div class="portlet_title">
|
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<h3>Subscription</h3>
|
||
</div>
|
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<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Subscription.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_Subscription" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Subscription.Shutter"></a>
|
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</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/mailman/listinfo/refseq-announce">RefSeq</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<!-- <component id="Gene_RVFullReport.Gene_RightColMenuLinks"/>-->
|
||
<div class="portlet">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
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<h3>Recent activity</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="recent_activity" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.Shutter"></a>
|
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<div class="portlet_content">
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|
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<div class="action">
|
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<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.ClearHistory" sid="1" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.ClearHistory" cmd="ClearHT" href="?cmd=ClearHT&" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.ClearHistory">
|
||
Clear
|
||
</a>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" sid="1" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOn" cmd="HTOff" href="?cmd=HTOff&" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle">
|
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Turn Off
|
||
</a>
|
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<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" sid="2" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOff" cmd="HTOn" href="?cmd=HTOn&" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle">
|
||
Turn On
|
||
</a>
|
||
</div>
|
||
<ul id="activity">
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67c9d8e7a68b6b5afc44f261">CD4 CD4 molecule [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">CD4 CD4 molecule [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:920</div></div>
|
||
<div class="tertiary">Gene</div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67c9d8e584f3725e590b01d7">T-cell surface glycoprotein CD4 isoform 1 precursor [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">T-cell surface glycoprotein CD4 isoform 1 precursor [Homo sapiens]<div class="brieflinkpopdesc">gi|10835167|ref|NP_000607.1|</div></div>
|
||
<div class="tertiary">Protein</div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67c9d8e4f4a390645e0b183b">CD3G CD3 gamma subunit of T-cell receptor complex [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">CD3G CD3 gamma subunit of T-cell receptor complex [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:917</div></div>
|
||
<div class="tertiary">Gene</div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67c9d8e2b15b832ebcdf641d">T-cell surface glycoprotein CD3 gamma chain precursor [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">T-cell surface glycoprotein CD3 gamma chain precursor [Homo sapiens]<div class="brieflinkpopdesc">gi|4557429|ref|NP_000064.1|</div></div>
|
||
<div class="tertiary">Protein</div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67c9d8e0b15b832ebcdf54e5">CD3E CD3 epsilon subunit of T-cell receptor complex [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">CD3E CD3 epsilon subunit of T-cell receptor complex [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:916</div></div>
|
||
<div class="tertiary">Gene</div>
|
||
</li>
|
||
</ul>
|
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<p class="HTOn">Your browsing activity is empty.</p>
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<p class="HTOff">Activity recording is turned off.</p>
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<p id="turnOn" class="HTOff">
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<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryOn" sid="1" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryOn" cmd="HTOn" href="?cmd=HTOn&" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryOn">Turn recording back on</a>
|
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</p>
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<a class="seemore" href="/sites/myncbi/recentactivity">See more...</a>
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