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<title>YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon [Homo sapiens (human)] - Gene - NCBI</title>
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<div class="search"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="pubmed">PubMed</option><option value="clinvar">ClinVar</option><option value="medgen">MedGen</option><option value="books" class="last">Books</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly" data-ac_dict="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene" selected="selected" data-ac_dict="gene">Gene</option><option value="genome" data-ac_dict="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen">MedGen</option><option value="mesh">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore" data-ac_dict="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein" data-ac_dict="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search Gene. Use up and down arrows to choose an item from the autocomplete." value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="dictionary:'gene',disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'yes',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div><ul class="searchlinks inline_list"><set></set><li><a href="/gene/advanced">Advanced</a></li><li class="help"><a id="help" class="jig-ncbihelpwindow" target="ncbihelp" name="help" href="/books/NBK3841/">Help</a></li></ul></div>
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<div class="facet_cont" data-db="gene" data-default_grps="fg_gene-sources,fg_categories,fg_sequence-content,fg_status" data-sd="db:'gene',op:'select',term:'',qk:'4627',linkname:'',idsfromresult:'7531',extra:''"><ul class="facet" data-filter_id="gene-sources" id="_gene-sources"><li class="filter_grp "><div class="clearfix"><h3>Gene sources</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="genomic">Genomic</a></li></ul></li></ul><ul class="facet" data-filter_id="categories" id="_categories"><li class="filter_grp "><div class="clearfix"><h3>Categories</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="alt-splicing">Alternatively spliced</a></li><li class="fil_val"><a href="#" data-value_id="annotated-genes">Annotated genes</a></li><li class="fil_val"><a href="#" data-value_id="gene-type-protein-coding">Protein-coding</a></li></ul></li></ul><ul class="facet" data-filter_id="sequence-content" id="_sequence-content"><li class="filter_grp "><div class="clearfix"><h3>Sequence content</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="seq-ccds">CCDS</a></li><li class="fil_val"><a href="#" data-value_id="seq-ensembl">Ensembl</a></li><li class="fil_val"><a href="#" data-value_id="refseq">RefSeq</a></li><li class="fil_val"><a href="#" data-value_id="seq-refseqgene">RefSeqGene</a></li></ul></li></ul><ul class="facet" data-filter_id="status" id="_status"><li class="filter_grp "><div class="clearfix"><h3>Status</h3><a href="#" data-value_id="" class="clear clear_show">Clear</a></div><ul><li class="fil_val selected"><a href="#" data-value_id="current-only">Current</a><span class="fcount">(1)</span></li></ul></li></ul><div id="chr-location-facet-wrapper" data-bid="MCID_67c9e8b4d74f67691042f830" data-hid="MCID_67c90f2d64f30b25346ccae2" data-qky="4627" class="disabled" style="display:none"><ul class="facet" data-filter_id="chromosomal-region" id="_chromosomal-region" data-of="yes"><li class="filter_grp of_grp"><div class="clearfix"><h3>Chromosome locations</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><a id="facet_ofchromosomal-region" href="#facet_of_divchromosomal-region" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'middle left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '375px'" data-value_id="fetch_more">more...</a><div id="facet_of_divchromosomal-region" style="display:none;" class="of_popup"><h4>Chromosome locations</h4><label for="organism-filter" style="width:100%;margin-bottom:.2em;" class="">Select an organism by typing or scrolling</label><input type="text" placeholder="Enter text to narrow down the list" id="organism-filter" style="width:98%;" autocomplete="off" /><br /><div id="chr-region-tax-list"><select id="of_chromosomal-region" size="9" class="chr-region-tax-list" style="width:100%;"></select></div><div id="chr-location-info-ctrl" data-disabled="disabled"><div class="chr-field"><label for="chr-name">Chromosome</label><br /><select id="chr-name" class="chr-field" disabled="disabled"></select></div><div class="chr-field"><label for="chr-from">From</label><br /><input type="text" name="chr-from" id="chr-from" disabled="disabled" class="chr-field" /></div><div class="chr-field"><label for="chr-to">To</label><br /><input type="text" name="chr-to" id="chr-to" disabled="disabled" class="chr-field" /></div></div><div class="actions clearfix"><button class="jig-ncbibutton of_add apply-chr" data-jigconfig="'color': 'ui-ncbibutton-blue'">Apply</button></div></div></ul></li></ul></div><ul class="facet facet_reset"><li><a href="#" data-value_id="reset">Clear all</a></li></ul><ul class="facet_tools"><li><a id="more_filter_groups_link" href="#more_filter_groups" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'top left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '180px'">
Show additional filters</a></li><div id="more_filter_groups" style="display:none;" class="facets_dialog"><button class="ui-ncbipopper-close-button ui-ncbipopper-close-button-generated ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-blue" generated="true" role="button" aria-disabled="false"><span class="ui-button-text">x</span></button><h4>Additional filters</h4><ul class="filter_groups_more facet"><li><input type="checkbox" id="fg_gene-sources" /><label for="fg_gene-sources">Gene sources</label></li><li><input type="checkbox" id="fg_categories" /><label for="fg_categories">Categories</label></li><li><input type="checkbox" id="fg_sequence-content" /><label for="fg_sequence-content">Sequence content</label></li><li><input type="checkbox" id="fg_status" /><label for="fg_status">Status</label></li><li><input type="checkbox" id="fg_chromosomal-region" /><label for="fg_chromosomal-region">Chromosome locations</label></li><li><input id="fg_field_search" type="checkbox" /><label for="fg_field_search">Search fields</label></li></ul><div class="actions clearfix"><button class="filter_groups_more_apply jig-ncbibutton primary-action" id="filter_groups_apply" data-jigconfig="'color': 'ui-ncbibutton-blue'">Show</button></div></div></ul><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetsUrlFrag" sid="1" type="hidden" value="filters=current-only" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetSubmitted" sid="1" type="hidden" value="false" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.BMFacets" sid="1" type="hidden" value="" /></div>
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<h1 class="title" id="gene-name"><span class="gn" style="padding-right:.5em;">YWHAE</span> tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon [ <em class="tax">Homo sapiens</em> (human)
]
</h1>
<span class="geneid">Gene ID: 7531, updated on
4-Mar-2025</span>
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<div class="rprt-section gene-summary">
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<dl id="summaryDl">
<dt class="noline"> Official
Symbol</dt>
<dd class="noline">YWHAE<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
<dt> Official
Full Name</dt>
<dd>tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
<dt>Primary source</dt>
<dd>
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12851" data-gblink-text="Ensembl">HGNC:HGNC:12851</a>
</dd>
<dt>See related</dt>
<dd>
<a href="http://www.ensembl.org/id/ENSG00000108953" data-gblink-text="Ensembl" class="genome-browser-link" data-genome-browser-link-sort="5" data-gb-url="http://www.ensembl.org/loc/ENSG00000108953">Ensembl:ENSG00000108953</a>
<a href="https://www.ncbi.nlm.nih.gov/omim/605066" data-gblink-text="Ensembl" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=605066">MIM:605066;</a>
<a href="https://www.alliancegenome.org/gene/HGNC:12851" data-gblink-text="Ensembl" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=HGNC:12851">AllianceGenome:HGNC:12851</a>
</dd>
<dt>Gene type</dt>
<dd>protein coding</dd>
<dt>RefSeq status</dt>
<dd>REVIEWED</dd>
<dt>Organism</dt>
<dd class="tax">
<a href="/Taxonomy/Browser/wwwtax.cgi?id=9606" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=9606">Homo sapiens</a>
</dd>
<dt>Lineage</dt>
<dd class="tax">Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo</dd>
<dt>Also known as</dt>
<dd>MDS; HEL2; MDCR; KCIP-1; 14-3-3E</dd>
<dt>Summary</dt>
<dd>This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]</dd>
<dt>Expression</dt>
<dd>Ubiquitous expression in brain (RPKM 317.4), kidney (RPKM 169.5) and 25 other tissues <a href="#gene-expression">See more</a></dd>
<dt>Orthologs</dt>
<dd class="ortholog-links">
<a href="https://www.ncbi.nlm.nih.gov/gene/22627">mouse</a>
<a href="/gene/7531/ortholog/">all</a>
</dd>
<dt style="padding-top:.5em;">
<span class="new-icon">NEW</span>
</dt>
<dd style="padding-top:.5em;">
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/7531/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="gene_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Gene table</a></strong>
<br />
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/7531/products/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="transcript_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Transcript table</a></strong>
</dd>
</dl>
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<div class="rprt-section gene-genomic-context">
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<div class="rprt-section-body">
<div class="gc_cont">
<div class="gt_cont_contents">
<div style="float:right"><span>See YWHAE in </span><a href="/genome/gdv/?context=gene&amp;acc=7531" class="link-to-gdv genome-browser-link" data-genome-browser-link-sort="1" data-acc="GCF_000001405.40">Genome Data Viewer</a> </div>
<dl class="dl-chr-info" style="float:left;margin-top:0;">
<dt>Location: </dt>
<dd>
<span style="display:inline-block;">17p13.3</span>
</dd>
</dl>
</div>
<dl class="dl-chr-info exon-count">
<dt>Exon count: </dt>
<dd>7</dd>
</dl>
<div class="ui-ncbigrid-outer-div" id="genomic-context-tbl-location">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="">
<thead>
<tr>
<th style="max-width:15%">Annotation release</th>
<th style="max-width:10%">Status</th>
<th>Assembly</th>
<th>
<span title="Chromosome">Chr</span>
</th>
<th>Location</th>
</tr>
</thead>
<tbody>
<tr>
<td>RS_2024_08</td>
<td>current</td>
<td>GRCh38.p14 (<a href="/assembly/GCF_000001405.40/" ref="ncbi_uid=7531&amp;link_uid=GCF_000001405.40">GCF_000001405.40</a>)</td>
<td>17</td>
<td>NC_000017.11 (1344275..1400222, complement) </td>
</tr>
<tr>
<td>RS_2024_08</td>
<td>current</td>
<td>T2T-CHM13v2.0 (<a href="/assembly/GCF_009914755.1/" ref="ncbi_uid=7531&amp;link_uid=GCF_009914755.1">GCF_009914755.1</a>)</td>
<td>17</td>
<td>NC_060941.1 (1232983..1288946, complement) </td>
</tr>
<tr>
<td>RS_2024_09</td>
<td>previous assembly</td>
<td>GRCh37.p13 (<a href="/assembly/GCF_000001405.25/" ref="ncbi_uid=7531&amp;link_uid=GCF_000001405.25">GCF_000001405.25</a>)</td>
<td>17</td>
<td>NC_000017.10 (1247569..1303516, complement) </td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<p class="withnote margin_t2em"><strong>Chromosome 17 - NC_000017.11</strong><img usemap="#nbrMap7531_568815581" border="0" alt="Genomic Context describing neighboring genes" src="/gutils/geneneighb.fcgi?geneid=7531&amp;nuc_gi=568815581&amp;n0=BHLHA9&amp;n1=LOC127885322&amp;n2=TRARG1&amp;n3=LOC127885323&amp;n4=YWHAE&amp;n5=LOC121848004&amp;n6=LOC127885324&amp;n7=LOC127885325&amp;n8=LOC127885326&amp;n9=LOC127885327&amp;n10=LOC127885328&amp;n11=LOC127885329&amp;n12=CRK&amp;n13=LOC127885330&amp;n14=LOC127885331&amp;n15=LOC112529892&amp;n16=LOC127885332&amp;n17=LOC127885333&amp;n18=LOC130059877&amp;n19=LOC127885334&amp;n20=MYO1C&amp;n21=LOC127885335&amp;n22=LOC130059878&amp;n23=LOC130059879&amp;n24=LOC130059880&amp;n25=LOC130059881&amp;n26=LOC130059882&amp;n27=LOC130059883&amp;n28=LOC130059884&amp;n29=LOC127885336" /><map name="nbrMap7531_568815581" id="nbrMap7531_568815581">
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr17:1174140-1174890')" onMouseOut="hidetip()" coords="3,23,73,31" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1174140-1174890" href="/gene/127885322" />
<area shape="rect" onMouseOver="showtip(this,event,'basic helix-loop-helix family member a9')" onMouseOut="hidetip()" coords="32,35,72,43" alt="Neighboring gene basic helix-loop-helix family member a9" href="/gene/727857" />
<area shape="rect" onMouseOver="showtip(this,event,'trafficking regulator of GLUT4 (SLC2A4) 1 (gene/pseudogene)')" onMouseOut="hidetip()" coords="47,47,113,55" alt="Neighboring gene trafficking regulator of GLUT4 (SLC2A4) 1 (gene/pseudogene)" href="/gene/286753" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr17:1202102-1202696')" onMouseOut="hidetip()" coords="48,59,118,67" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1202102-1202696" href="/gene/127885323" />
<area shape="rect" onMouseOver="showtip(this,event,'Sharpr-MPRA regulatory region 14526')" onMouseOut="hidetip()" coords="127,23,197,31" alt="Neighboring gene Sharpr-MPRA regulatory region 14526" href="/gene/121848004" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1295206-1295734')" onMouseOut="hidetip()" coords="198,23,268,31" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1295206-1295734" href="/gene/127885324" />
<area shape="rect" onMouseOver="showtip(this,event,'NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1302101-1302738')" onMouseOut="hidetip()" coords="209,47,279,55" alt="Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1302101-1302738" href="/gene/127885325" />
<area shape="rect" onMouseOver="showtip(this,event,'NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1302739-1303376')" onMouseOut="hidetip()" coords="210,59,280,67" alt="Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1302739-1303376" href="/gene/127885326" />
<area shape="rect" onMouseOver="showtip(this,event,'NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1303377-1304014')" onMouseOut="hidetip()" coords="211,71,281,79" alt="Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1303377-1304014" href="/gene/127885327" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr17:1304957-1305572')" onMouseOut="hidetip()" coords="214,83,284,91" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1304957-1305572" href="/gene/127885328" />
<area shape="rect" onMouseOver="showtip(this,event,'NANOG-H3K4me1 hESC enhancer GRCh37_chr17:1305573-1306188')" onMouseOut="hidetip()" coords="215,95,285,103" alt="Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:1305573-1306188" href="/gene/127885329" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr17:1335344-1335844')" onMouseOut="hidetip()" coords="263,107,333,115" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1335344-1335844" href="/gene/127885330" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr17:1335845-1336345')" onMouseOut="hidetip()" coords="264,119,334,127" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1335845-1336345" href="/gene/127885331" />
<area shape="rect" onMouseOver="showtip(this,event,'Sharpr-MPRA regulatory region 4720')" onMouseOut="hidetip()" coords="274,23,344,31" alt="Neighboring gene Sharpr-MPRA regulatory region 4720" href="/gene/112529892" />
<area shape="rect" onMouseOver="showtip(this,event,'CRK proto-oncogene, adaptor protein')" onMouseOut="hidetip()" coords="290,35,364,43" alt="Neighboring gene CRK proto-oncogene, adaptor protein" href="/gene/1398" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr17:1357059-1357560')" onMouseOut="hidetip()" coords="298,47,368,55" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1357059-1357560" href="/gene/127885332" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1358695-1359680')" onMouseOut="hidetip()" coords="301,59,371,67" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1358695-1359680" href="/gene/127885333" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 11449')" onMouseOut="hidetip()" coords="313,71,383,79" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11449" href="/gene/130059877" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1366499-1367318')" onMouseOut="hidetip()" coords="313,83,383,91" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1366499-1367318" href="/gene/127885334" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr17:1371831-1372451')" onMouseOut="hidetip()" coords="322,95,392,103" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1371831-1372451" href="/gene/127885335" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 7954')" onMouseOut="hidetip()" coords="331,131,401,139" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7954" href="/gene/130059878" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 11450')" onMouseOut="hidetip()" coords="332,143,402,151" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11450" href="/gene/130059879" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 11451')" onMouseOut="hidetip()" coords="333,155,403,163" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11451" href="/gene/130059880" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 11452')" onMouseOut="hidetip()" coords="348,23,418,31" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11452" href="/gene/130059881" />
<area shape="rect" onMouseOver="showtip(this,event,'myosin IC')" onMouseOut="hidetip()" coords="350,107,423,115" alt="Neighboring gene myosin IC" href="/gene/4641" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 7955')" onMouseOut="hidetip()" coords="350,119,420,127" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7955" href="/gene/130059882" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 7956')" onMouseOut="hidetip()" coords="352,167,422,175" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7956" href="/gene/130059883" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 7957')" onMouseOut="hidetip()" coords="353,179,423,187" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7957" href="/gene/130059884" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1394312-1395031')" onMouseOut="hidetip()" coords="353,191,423,199" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1394312-1395031" href="/gene/127885336" />
</map>
</p>
</div>
</div>
<div class="rprt-section gene-genomic-regions-transcripts-products">
<section class="rprt-section-header" id="genomic-regions-transcripts-products">
<h2 id="header-genomic-regions-transcripts-products">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-regions-transcripts-products .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Genomic regions, transcripts, and products</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Genomic_Regions_Transcripts_a" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<div style="text-align:right;">Go to <a href="#reference-sequences">reference sequence details</a></div>
</div>
<div>
<p class="choose">
<label for="accession" class="label">Genomic Sequence: </label>
<select name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.accessionList" sid="1" id="accessionList" data-taxid="9606" data-geneid="7531">
<option value="NC_000017.11_1344274_1400221">NC_000017.11 Chromosome 17 Reference GRCh38.p14 Primary Assembly</option>
<option value="NT_187613.1_286300_342247">NT_187613.1 Chromosome 17 Reference GRCh38.p14 ALT_REF_LOCI_1</option>
<option value="NG_009233.1_5040_60987">NG_009233.1 RefSeqGene</option>
<option value="NC_060941.1_1232982_1288945">NC_060941.1 Chromosome 17 Alternate T2T-CHM13v2.0</option>
<option value="NC_000017.10_1247568_1303515">NC_000017.10 Chromosome 17 Reference GRCh37.p13 Primary Assembly</option>
</select>
</p>
</div>
<div id="NC_000017" class="divAccession">
<div class="seq-viewer">
<p class="note-link">
<strong>Go to nucleotide:</strong>
<a title="Nucleotide Graphic report" href="/nuccore/NC_000017.11?report=graph&amp;from=1335882&amp;to=1408613&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=NC_000017.11">Graphics</a>
<a title="Nucleotide FASTA report" href="/nuccore/NC_000017.11?report=fasta&amp;from=1344275&amp;to=1400222&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=NC_000017.11">FASTA</a>
<a title="Nucleotide GenBank report" href="/nuccore/NC_000017.11?report=genbank&amp;from=1344275&amp;to=1400222&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=NC_000017.11">GenBank</a>
</p>
<div id="divNC_000017" class="SeqViewerApp" style="clear:both;" data-sv="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000017.11&amp;from=1335882&amp;to=1408613&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40">
<a href="?appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000017.11&amp;from=1335882&amp;to=1408613&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40"></a>
</div>
</div>
</div>
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000017.11" sid="1" type="hidden" id="nucleotideLink_NC_000017_11_1344274_1400221" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_000017.11?report=graph&amp;amp;from=1335882&amp;amp;to=1408613&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.40&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=7531&amp;amp;link_uid=NC_000017.11&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_000017.11?report=fasta&amp;amp;from=1344275&amp;amp;to=1400222&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=7531&amp;amp;link_uid=NC_000017.11&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_000017.11?report=genbank&amp;amp;from=1344275&amp;amp;to=1400222&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=7531&amp;amp;link_uid=NC_000017.11&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000017.11" sid="1" type="hidden" id="relString_NC_000017_11_1344274_1400221" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_000017.11&amp;amp;from=1335882&amp;amp;to=1408613&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.40" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NT_187613.1" sid="1" type="hidden" id="nucleotideLink_NT_187613_1_286300_342247" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NT_187613.1?report=graph&amp;amp;from=277908&amp;amp;to=350639&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.40&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=7531&amp;amp;link_uid=NT_187613.1&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NT_187613.1?report=fasta&amp;amp;from=286301&amp;amp;to=342248&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=7531&amp;amp;link_uid=NT_187613.1&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NT_187613.1?report=genbank&amp;amp;from=286301&amp;amp;to=342248&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=7531&amp;amp;link_uid=NT_187613.1&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NT_187613.1" sid="1" type="hidden" id="relString_NT_187613_1_286300_342247" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NT_187613.1&amp;amp;from=277908&amp;amp;to=350639&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.40" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NG_009233.1" sid="1" type="hidden" id="nucleotideLink_NG_009233_1_5040_60987" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NG_009233.1?report=graph&amp;amp;from=1&amp;amp;to=69379&amp;amp;tracks=[key:sequence_track,name:Sequence,display_name:Sequence,category:Sequence,annots:Sequence,ShowLabel:false][key:gene_model_track,name:Genes---Unnamed,display_name:Genes,annots:Unnamed,Options:ShowAllButGenes,SNPs:false,CDSProductFeats:false,ShowLabelsForAllFeatures:true,HighlightMode:2][key:SNP_track,name:SNP,annots:SNP,Layout:Adaptive][key:SNP_Bins_track,name:Clinical Variants][key:SNP_Bins_track,name:Cited Variants][key:GWAS_track,name:GWAS Tracks,display_name:Association Results][key:alignment_track,category:Alignments,annots:Unnamed][key:alignment_track,category:Alignments,annots:NA000079160.1][key:alignment_track,category:Alignments,annots:NA000010065.1]&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=7531&amp;amp;link_uid=NG_009233.1&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NG_009233.1?report=fasta&amp;amp;from=5041&amp;amp;to=60988&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=7531&amp;amp;link_uid=NG_009233.1&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NG_009233.1?report=genbank&amp;amp;from=5041&amp;amp;to=60988&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=7531&amp;amp;link_uid=NG_009233.1&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NG_009233.1" sid="1" type="hidden" id="relString_NG_009233_1_5040_60987" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NG_009233.1&amp;amp;from=1&amp;amp;to=69379&amp;amp;tracks=[key:sequence_track,name:Sequence,display_name:Sequence,category:Sequence,annots:Sequence,ShowLabel:false][key:gene_model_track,name:Genes---Unnamed,display_name:Genes,annots:Unnamed,Options:ShowAllButGenes,SNPs:false,CDSProductFeats:false,ShowLabelsForAllFeatures:true,HighlightMode:2][key:SNP_track,name:SNP,annots:SNP,Layout:Adaptive][key:SNP_Bins_track,name:Clinical Variants][key:SNP_Bins_track,name:Cited Variants][key:GWAS_track,name:GWAS Tracks,display_name:Association Results][key:alignment_track,category:Alignments,annots:Unnamed][key:alignment_track,category:Alignments,annots:NA000079160.1][key:alignment_track,category:Alignments,annots:NA000010065.1]" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_060941.1" sid="1" type="hidden" id="nucleotideLink_NC_060941_1_1232982_1288945" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_060941.1?report=graph&amp;amp;from=1224588&amp;amp;to=1297339&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_009914755.1&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=7531&amp;amp;link_uid=NC_060941.1&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_060941.1?report=fasta&amp;amp;from=1232983&amp;amp;to=1288946&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=7531&amp;amp;link_uid=NC_060941.1&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_060941.1?report=genbank&amp;amp;from=1232983&amp;amp;to=1288946&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=7531&amp;amp;link_uid=NC_060941.1&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_060941.1" sid="1" type="hidden" id="relString_NC_060941_1_1232982_1288945" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_060941.1&amp;amp;from=1224588&amp;amp;to=1297339&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_009914755.1" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000017.10" sid="1" type="hidden" id="nucleotideLink_NC_000017_10_1247568_1303515" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_000017.10?report=graph&amp;amp;from=1239176&amp;amp;to=1311907&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.25&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=7531&amp;amp;link_uid=NC_000017.10&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_000017.10?report=fasta&amp;amp;from=1247569&amp;amp;to=1303516&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=7531&amp;amp;link_uid=NC_000017.10&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_000017.10?report=genbank&amp;amp;from=1247569&amp;amp;to=1303516&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=7531&amp;amp;link_uid=NC_000017.10&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000017.10" sid="1" type="hidden" id="relString_NC_000017_10_1247568_1303515" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_000017.10&amp;amp;from=1239176&amp;amp;to=1311907&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.25" />
</div>
</div>
<div class="rprt-section gene-gene-expression">
<section class="rprt-section-header" id="gene-expression">
<h2 id="header-gene-expression">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-gene-expression .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Expression</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Expression" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<div style="text-align:right;">
<a href="/gene/7531/?report=expression" data-url="/gene/7531/?report=expression" id="gene-expression-see-details">See details</a>
</div>
<div id="gene-expression-app" data-url="https://www.ncbi.nlm.nih.gov/gene/7531" data-report-type="summary">
<div>
<script type="text/javascript">
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<option value="SRP051249" selected="selected" data-bioproject="PRJNA270632">
Tissue-specific circular RNA induction during human fetal development
</option>
<option value="SRP056969" data-bioproject="PRJNA280600">
RNA sequencing of total RNA from 20 human tissues
</option>
<option value="ERP003613" data-bioproject="PRJEB4337">
HPA RNA-seq normal tissues
</option>
</select>
<ul id="project-summary">
<li id="project-summary-title">Project title:
Tissue-specific circular RNA induction during human fetal development
</li>
<li id="project-summary-desc">Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA</li>
<li id="project-summary-bioprojects">BioProject: <a href="/bioproject/PRJNA270632/">PRJNA270632</a>
</li>
<li id="project-summary-pubs">Publication:
<span><a href="/pubmed/26076956/">PMID 26076956</a></span>
</li>
<li id="project-summary-analysis-date">Analysis date: Mon Apr 2 22:54:59 2018</li>
</ul>
<div id="gene-expr-details" class="expression-chart"></div>
</div>
</div>
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<section class="rprt-section-header" id="bibliography"><h2 id="header-bibliography"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-bibliography .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Bibliography</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Bibliography" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
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<h3 id="relatedarticlesinpubmed">
<a href="#" class="jig-ncbitoggler-open">Related articles in PubMed</a>
</h3>
<div class="generefbl-link">
<ol class="generef-link">
<li>
<a href="/pubmed/24561237/" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=24561237">The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and orbitofrontal sulcogyral pattern in patients with schizophrenia and healthy subjects.</a>
<span class="pubmed-auth-date"> Takahashi T, <em>et al</em>. Prog Neuropsychopharmacol Biol Psychiatry, 2014 Jun 3. PMID 24561237</span>
</li>
<li>
<a href="/pubmed/22887762/" ref="ordinalpos=2&amp;ncbi_uid=7531&amp;link_uid=22887762">Expression analysis of a 17p terminal deletion, including YWHAE, but not PAFAH1B1, associated with normal brain structure on MRI in a young girl.</a>
<span class="pubmed-auth-date"> Enomoto K, <em>et al</em>. Am J Med Genet A, 2012 Sep. PMID 22887762</span>
</li>
<li>
<a href="/pubmed/20417184/" ref="ordinalpos=3&amp;ncbi_uid=7531&amp;link_uid=20417184">Functional identification of a novel 14-3-3 epsilon splicing variant suggests dimerization is not necessary for 14-3-3 epsilon to inhibit UV-induced apoptosis.</a>
<span class="pubmed-auth-date"> Han D, <em>et al</em>. Biochem Biophys Res Commun, 2010 May 28. PMID 20417184</span>
</li>
<li>
<a href="/pubmed/35545369/" ref="ordinalpos=4&amp;ncbi_uid=7531&amp;link_uid=35545369">Genetic variation of YWHAE gene-"Switch" of disease control.</a>
<span class="pubmed-auth-date"> Jin X, <em>et al</em>. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2022 Jan 28. PMID 35545369, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC10930477/" ref="ordinalpos=0&amp;ncbi_uid=7531&amp;link_uid=PMC10930477">Free PMC Article</a></span></span>
</li>
<li>
<a href="/pubmed/36433683/" ref="ordinalpos=5&amp;ncbi_uid=7531&amp;link_uid=36433683">Further expansion and confirmation of phenotype in rare loss of YWHAE gene distinct from Miller-Dieker syndrome.</a>
<span class="pubmed-auth-date"> Baker EK, <em>et al</em>. Am J Med Genet A, 2023 Feb. PMID 36433683, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC10099970/" ref="ordinalpos=0&amp;ncbi_uid=7531&amp;link_uid=PMC10099970">Free PMC Article</a></span></span>
</li>
</ol>
<p class="see-all-pm">
<a href="/pubmed?LinkName=gene_pubmed&amp;from_uid=7531" title="See all 582 citations in Pubmed">See all (582) citations in PubMed</a>
</p>
</div>
</div>
<div class="generif-pubmed generif">
<h3 id="generifsgenereferencesintofunctions">
<a href="#" class="jig-ncbitoggler-open">GeneRIFs: Gene References Into Functions</a>
</h3>
<div>
<a href="/gene/about-generif" class="whatisthis">What's a GeneRIF?</a>
<div class="generefbl-link">
<ol class="generef-link">
<li class="gene-rif-popper">
<a href="/pubmed/38750908" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=38750908">14-3-3epsilon/YWHAE regulates the transcriptional expression of cardiac sodium channel NaV1.5.</a>
<div id="gene-popper1" class="gene-rif-popper">Title: 14-3-3ε/YWHAE regulates the transcriptional expression of cardiac sodium channel Na(V)1.5.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/38361148" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=38361148">Exosomes from Intrahepatic Cholestasis of Pregnancy Induce Cell Apoptosis Through the miRNA-6891-5p/YWHAE Pathway.</a>
<div id="gene-popper2" class="gene-rif-popper">Title: Exosomes from Intrahepatic Cholestasis of Pregnancy Induce Cell Apoptosis Through the miRNA-6891-5p/YWHAE Pathway.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/38363382" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=38363382">The novel miR-873-5p-YWHAE-PI3K/AKT axis is involved in non-small cell lung cancer progression and chemoresistance by mediating autophagy.</a>
<div id="gene-popper3" class="gene-rif-popper">Title: The novel miR-873-5p-YWHAE-PI3K/AKT axis is involved in non-small cell lung cancer progression and chemoresistance by mediating autophagy.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/38001345" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=38001345">Comprehensive analysis of the function of helicobacter-associated ferroptosis gene YWHAE in gastric cancer through multi-omics integration, molecular docking, and machine learning.</a>
<div id="gene-popper4" class="gene-rif-popper">Title: Comprehensive analysis of the function of helicobacter-associated ferroptosis gene YWHAE in gastric cancer through multi-omics integration, molecular docking, and machine learning.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/38279176" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=38279176">14-3-3epsilon: a protein with complex physiology function but promising therapeutic potential in cancer.</a>
<div id="gene-popper5" class="gene-rif-popper">Title: 14-3-3ε: a protein with complex physiology function but promising therapeutic potential in cancer.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/37599448" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=37599448">Nucleo-cytoplasmic shuttling of 14-3-3 epsilon carrying hnRNP C promotes autophagy.</a>
<div id="gene-popper6" class="gene-rif-popper">Title: Nucleo-cytoplasmic shuttling of 14-3-3 epsilon carrying hnRNP C promotes autophagy.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/36999555" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=36999555">YWHAE loss of function causes a rare neurodevelopmental disease with brain abnormalities in human and mouse.</a>
<div id="gene-popper7" class="gene-rif-popper">Title: YWHAE loss of function causes a rare neurodevelopmental disease with brain abnormalities in human and mouse.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/37202194" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=37202194">[NKD1 promotes glucose uptake in colon cancer cells by activating YWHAE transcription].</a>
<div id="gene-popper8" class="gene-rif-popper">Title: [NKD1 promotes glucose uptake in colon cancer cells by activating YWHAE transcription].</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/36433683" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=36433683">Further expansion and confirmation of phenotype in rare loss of YWHAE gene distinct from Miller-Dieker syndrome.</a>
<div id="gene-popper9" class="gene-rif-popper">Title: Further expansion and confirmation of phenotype in rare loss of YWHAE gene distinct from Miller-Dieker syndrome.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/35545369" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=35545369">Genetic variation of YWHAE gene-""Switch"" of disease control.", trans "YWHAE--"""".</a>
<div id="gene-popper10" class="gene-rif-popper">Title: Genetic variation of YWHAE gene-"Switch" of disease control.</div>
</li>
</ol>
</div>
<div class="submit-genrif">
<span>Submit:</span>
<a href="/gene/submit-generif/?geneId=7531&amp;sym=YWHAE&amp;name=tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon&amp;org=Homo sapiens">New GeneRIF</a>
<a href="/RefSeq/update.cgi?geneid=7531&amp;symbol=YWHAE;task=fixpub">Correction</a>
<a href="https://www.ncbi.nlm.nih.gov/gene?db=gene&amp;report=generif&amp;term=7531" class="seeall-generif">See all GeneRIFs (99)</a>
</div>
</div>
</div>
</div>
</div>
<div class="rprt-section gene-phenotypes">
<section class="rprt-section-header" id="phenotypes">
<h2 id="header-phenotypes">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-phenotypes .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Phenotypes</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Phenotype" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body info-phenotype">
<p class="nochild-link">
<a href="/gtr/tests/?term=YWHAE[gene]">Find tests for this gene in the NIH Genetic Testing Registry (GTR)</a>
</p>
<p class="nochild-link">
<a href="/gap/PheGenI?tab=1&amp;gene=7531">Review eQTL and phenotype association data in this region using PheGenI</a>
</p>
</div>
</div>
<div class="rprt-section gene-variation">
<section class="rprt-section-header" id="variation">
<h2 id="header-variation">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-variation .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Variation</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.variation" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<p class="nochild-link">
<a href="/clinvar/?term=YWHAE[gene]" ref="log$=recordlinks">See variants in ClinVar</a>
</p>
<p class="nochild-link">
<a href="/dbvar?LinkName=gene_dbvar&amp;from_uid=7531" ref="log$=recordlinks">See studies and variants in dbVar</a>
</p>
<p class="nochild-link">
<a href="/variation/view/?q=7531[geneid]&amp;assm=GCF_000001405.25" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh37.p13)">See Variation Viewer (GRCh37.p13)</a>
</p>
<p class="nochild-link">
<a href="/variation/view/?q=7531[geneid]" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh38)">See Variation Viewer (GRCh38)</a>
</p>
<set></set>
<set></set>
</div>
</div>
<div class="rprt-section gene-HIV-1-interactions">
<section class="rprt-section-header" id="HIV-1-interactions">
<h2 id="header-HIV-1-interactions">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-HIV-1-interactions .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">HIV-1 interactions</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.HIV1_interactions" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div class="fgrid">
<h3 id="proteininteractions">Protein interactions</h3>
<table summary="protein interactions" class="jig-ncbigrid">
<thead>
<tr>
<th id="hivprotein">Protein</th>
<th id="gene-hivprotein">Gene</th>
<th id="hivinter">Interaction</th>
<th id="hivpub">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="hivprotein">
<a href="/protein/28876544">Envelope surface glycoprotein gp120</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">HIV-1 gp120 downregulates expression of c-Myc, Max, and 14-3-3epsilon proteins, and decreases phosphorylation of ATP-dependent tyrosine kinases (Akt) at Ser-473 in human mesangial cells (HMC)</td>
<td headers="hivpub">
<a title="PubMed Id(s): 11208609" href="/pubmed/11208609">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/28872817">Vpr</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155807">vpr</a>
</td>
<td headers="hivinter">HIV-1 Vpr inhibits insulin-induced association of 14-3-3 and Foxo3a in HeLa cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 20012529,15708996,15265780" href="/pubmed/20012529,15708996,15265780">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155807">vpr</a>
</td>
<td headers="hivinter">Interaction of HIV-1 Vpr with human 14-3-3 protein is presumed based on homology to yeast DNA damage checkpoint protein rad25 which enhances HIV-1 Vpr-induced G2 arrest in vitro, most likely through the inhibition of Cdc25</td>
<td headers="hivpub">
<a title="PubMed Id(s): 20012529,16968670,15265780,15142377,11531413" href="/pubmed/20012529,16968670,15265780,15142377,11531413">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/25121908">integrase</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155348">gag-pol</a>
</td>
<td headers="hivinter">HIV-1 IN is identified to have a physical interaction with 14-3-3 epsilon (YWHAE) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses</td>
<td headers="hivpub">
<a title="PubMed Id(s): 22190034" href="/pubmed/22190034">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/25121906">retropepsin</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155348">gag-pol</a>
</td>
<td headers="hivinter">Positional proteomics analysis identifies the cleavage of human tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide (YWHAE; 14-3-3 protein epsilon) at amino acid residues 6-7 by the HIV-1 protease</td>
<td headers="hivpub">
<a title="PubMed Id(s): 22944692" href="/pubmed/22944692">PubMed</a>
</td>
</tr>
</tbody>
</table>
<p class="withnote">
<a class="note" href="/genome/viruses/retroviruses/hiv-1/interactions/">Go to the HIV-1, Human Interaction Database </a>
</p>
</div>
</div>
</div>
<div class="rprt-section gene-pathways">
<section class="rprt-section-header" id="pathways">
<h2 id="header-pathways">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-pathways .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Pathways from PubChem</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<ul class="geneinfo-subsec infopathway">
<iframe title="Pathways in which the gene target is involved" class="pubchem-widget" scrolling="no" src="https://pubchem.ncbi.nlm.nih.gov/gene/7531#section=Pathways&amp;embed=true&amp;hide_all_headings=true&amp;page_size=25" style="border: 0; width: 100%;"></iframe>
<script type="text/javascript" src="https://pubchem.ncbi.nlm.nih.gov/pcfe/libs/iframeResizer.min.js"></script>
<script type="text/javascript">iFrameResize({log: false, checkOrigin: false}, '.pubchem-widget')</script>
</ul>
</div>
</div>
<div class="rprt-section gene-interactions">
<section class="rprt-section-header" id="interactions">
<h2 id="header-interactions">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-interactions .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Interactions</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Interactions" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<table summary="Gene Interaction" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/7531/data/interaction/',webserviceParams: 'p$l=Ajax&amp;p$debugoutput=off', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
<thead>
<tr>
<th id="inter-prod">Products</th>
<th id="inter-interactant">Interactant</th>
<th id="inter-otherGene">Other Gene</th>
<th id="inter-compl">Complex</th>
<th id="inter-source">Source</th>
<th id="inter-pubs">Pubs</th>
<th id="inter-desc">Description</th>
</tr>
</thead>
<tbody></tbody>
</table>
</div>
</div>
<div class="rprt-section gene-general-gene-info">
<section class="rprt-section-header" id="general-gene-info">
<h2 id="header-general-gene-info">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-gene-info .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">General gene information</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.General_Gene_Information" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body" style="">
<div id="gene-markers">
<h3 id="markers">
<a class="jig-ncbitoggler">Markers</a>
</h3>
<div>
<ul class="marker odd">
<li class="marker">RH70591 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=88866%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=88866">UniSTS:88866</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">D17S1582 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=152394%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=152394">UniSTS:152394</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">G19934 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=20584%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=20584">UniSTS:20584</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">YWHAE__1220 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=277870%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=277870">UniSTS:277870</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">STS-T60849 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=2195%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=2195">UniSTS:2195</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">D17S1499E (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=151704%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=151704">UniSTS:151704</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">RH66862 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=85955%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=85955">UniSTS:85955</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">RH47135 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=70855%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=70855">UniSTS:70855</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">RH104444 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=83931%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=83931">UniSTS:83931</a></li></ul></li>
</ul>
</div>
</div>
<div>
<div class="infosec" id="Relatedpseudogenes"><h3 id="relatedpseudogenes"><a class="jig-ncbitoggler-open">Related pseudogene(s)</a></h3>
<dl class="geneinfo-subsec"><dt>8 found
 
<a href="/gene/?Term=related_functional_gene_7531%5Bgroup%5D">Review record(s) in Gene</a></dt></dl>
</div>
</div>
<div class="infosec">
<h3 id="homology">
<a class="jig-ncbitoggler-open">Homology</a>
</h3>
<ul class="geneinfo-subsec">
<li>
<a href="/gene/7531/ortholog/" id="ncbi-ortholog-link">NCBI Orthologs</a>
</li>
<a href="https://www.orthodb.org/?ncbi=7531" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8178" target="_blank">
Orthologs from OrthoDB
</a>
</ul>
</div>
<!--<component id="Gene_InfoPathway"/>-->
<div class="infosec info-comment" id="info-comment">
<h3 id="CloneNames">
<a class="jig-ncbitoggler-open">Clone Names</a>
</h3>
<ul class="geneinfo-subsec">
<li>FLJ45465, FLJ53559 </li>
</ul>
</div>
<div class="gene-ontology infosec">
<h3 id="gene-ontology">
<a class="jig-ncbitoggler-open">
<span>Gene Ontology</span>
</a>
<a target="_blank" href="http://www.ebi.ac.uk/GOA" class="g-ontology-src" title="Provided by GOA">Provided by GOA</a>
</h3>
<div class="ontology-tables">
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Function</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0023026">enables MHC class II protein complex binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> HDA</a>
<div id="evidence-code-1-0" class="ecode">
<br />
<a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a>
</div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/20458337" target="_blank" title="PubMed ID 20458337" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=20458337">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0003723">enables RNA binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> HDA</a>
<div id="evidence-code-2-0" class="ecode">
<br />
<a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a>
</div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/22658674" target="_blank" title="PubMed ID 22658674" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=22658674">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0045296">enables cadherin binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> HDA</a>
<div id="evidence-code-3-0" class="ecode">
<br />
<a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a>
</div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/25468996" target="_blank" title="PubMed ID 25468996" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=25468996">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0019855">enables calcium channel inhibitor activity</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-4-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/18029012" target="_blank" title="PubMed ID 18029012" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=18029012">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005246">enables calcium channel regulator activity</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-5-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/18029012" target="_blank" title="PubMed ID 18029012" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=18029012">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0019899">enables enzyme binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-6-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/10788521" target="_blank" title="PubMed ID 10788521" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=10788521">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0042826">enables histone deacetylase binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-7-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/10869435" target="_blank" title="PubMed ID 10869435" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=10869435">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0042802">enables identical protein binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-8-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/17085597,20936779" target="_blank" title="PubMed ID 17085597,20936779" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=17085597,20936779">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0051219">enables phosphoprotein binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-9-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/10869435" target="_blank" title="PubMed ID 10869435" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=10869435">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0050815">enables phosphoserine residue binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-10-0" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0050815">enables phosphoserine residue binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-11-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/10869435" target="_blank" title="PubMed ID 10869435" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=10869435">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0015459">enables potassium channel regulator activity</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-12-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-12-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/11953308" target="_blank" title="PubMed ID 11953308" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=11953308">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005515">enables protein binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-13-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-13-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/1266503,7644510,10644344,11504882,11697890,11784866,12392720,12917326,14743216,15023544,15696159,15722337,16099986,16189514,16227609,16260042,16306228,16376338,16407301,16511560,16775625,17043677,17085597,17461779,17979178,18045992,18227151,18356162,18458160,18573912,19172738,19331823,19640509,19935711,20562859,20618440,20642453,20936779,21044950,21242966,21282530,21988832,22151054,22246185,22863774,23075850,23275563,23572552,23622247,23752268,24255178,24366813,24725412,24947832,24981860,25036637,25189701,25332407,25588844,25751139,25852190,25959826,26184334,26496610,27030597,27173435,27880917,28514442,28877994,29100370,29106533,29128334,29769719,30611118,31046837,31413325,31980649,32296183,32707033,32814053,33961781,35271311,36096339,36931259,37045861,39251607" target="_blank" title="PubMed ID 1266503,7644510,10644344,11504882,11697890,11784866,12392720,12917326,14743216,15023544,15696159,15722337,16099986,16189514,16227609,16260042,16306228,16376338,16407301,16511560,16775625,17043677,17085597,17461779,17979178,18045992,18227151,18356162,18458160,18573912,19172738,19331823,19640509,19935711,20562859,20618440,20642453,20936779,21044950,21242966,21282530,21988832,22151054,22246185,22863774,23075850,23275563,23572552,23622247,23752268,24255178,24366813,24725412,24947832,24981860,25036637,25189701,25332407,25588844,25751139,25852190,25959826,26184334,26496610,27030597,27173435,27880917,28514442,28877994,29100370,29106533,29128334,29769719,30611118,31046837,31413325,31980649,32296183,32707033,32814053,33961781,35271311,36096339,36931259,37045861,39251607" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=1266503,7644510,10644344,11504882,11697890,11784866,12392720,12917326,14743216,15023544,15696159,15722337,16099986,16189514,16227609,16260042,16306228,16376338,16407301,16511560,16775625,17043677,17085597,17461779,17979178,18045992,18227151,18356162,18458160,18573912,19172738,19331823,19640509,19935711,20562859,20618440,20642453,20936779,21044950,21242966,21282530,21988832,22151054,22246185,22863774,23075850,23275563,23572552,23622247,23752268,24255178,24366813,24725412,24947832,24981860,25036637,25189701,25332407,25588844,25751139,25852190,25959826,26184334,26496610,27030597,27173435,27880917,28514442,28877994,29100370,29106533,29128334,29769719,30611118,31046837,31413325,31980649,32296183,32707033,32814053,33961781,35271311,36096339,36931259,37045861,39251607">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0019904">enables protein domain specific binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-14-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-14-0" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0046982">enables protein heterodimerization activity</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-15-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-15-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/11953308" target="_blank" title="PubMed ID 11953308" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=11953308">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0019903">enables protein phosphatase binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-16-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-16-0" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0004864">enables protein phosphatase inhibitor activity</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-17-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-17-0" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0140311">enables protein sequestering activity</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-18-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-18-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/22797923" target="_blank" title="PubMed ID 22797923" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=22797923">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0097110">enables scaffold protein binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-19-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-19-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/10409742" target="_blank" title="PubMed ID 10409742" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=10409742">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0035591">enables signaling adaptor activity</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-20-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-20-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/22607805" target="_blank" title="PubMed ID 22607805" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=22607805">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0044325">enables transmembrane transporter binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-21-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-21-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/11953308,18029012" target="_blank" title="PubMed ID 11953308,18029012" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=11953308,18029012">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0031625">enables ubiquitin protein ligase binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-22-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-22-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/19725078" target="_blank" title="PubMed ID 19725078" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=19725078">PubMed</a> </td>
</tr>
</tbody>
</table>
</div>
</div>
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Process</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0000165">involved_in MAPK cascade</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-1-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/12917326" target="_blank" title="PubMed ID 12917326" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=12917326">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0034605">involved_in cellular response to heat</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-2-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/12917326" target="_blank" title="PubMed ID 12917326" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=12917326">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0021987">involved_in cerebral cortex development</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-3-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0002753">involved_in cytoplasmic pattern recognition receptor signaling pathway</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-4-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/22607805" target="_blank" title="PubMed ID 22607805" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=22607805">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0021766">involved_in hippocampus development</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-5-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0030007">involved_in intracellular potassium ion homeostasis</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-6-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/22797923" target="_blank" title="PubMed ID 22797923" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=22797923">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0035556">involved_in intracellular signal transduction</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-7-1" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/7644510" target="_blank" title="PubMed ID 7644510" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=7644510">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0086013">involved_in membrane repolarization during cardiac muscle cell action potential</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IC</a>
<div id="evidence-code-8-1" class="ecode">Inferred by Curator<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/11953308" target="_blank" title="PubMed ID 11953308" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=11953308">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:1905913">involved_in negative regulation of calcium ion export across plasma membrane</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-9-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/18029012" target="_blank" title="PubMed ID 18029012" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=18029012">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0034122">involved_in negative regulation of toll-like receptor signaling pathway</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-10-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/35343654" target="_blank" title="PubMed ID 35343654" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=35343654">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0001764">involved_in neuron migration</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-11-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0035332">involved_in positive regulation of hippo signaling</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-12-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-12-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/11118213" target="_blank" title="PubMed ID 11118213" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=11118213">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0046827">involved_in positive regulation of protein export from nucleus</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-13-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-13-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/12917326" target="_blank" title="PubMed ID 12917326" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=12917326">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0008104">involved_in protein localization</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-14-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-14-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0070972">involved_in protein localization to endoplasmic reticulum</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-15-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-15-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/35343654" target="_blank" title="PubMed ID 35343654" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=35343654">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0034504">involved_in protein localization to nucleus</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-16-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-16-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/29769719" target="_blank" title="PubMed ID 29769719" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=29769719">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0006605">involved_in protein targeting</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-17-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-17-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0051480">involved_in regulation of cytosolic calcium ion concentration</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-18-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-18-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/18029012" target="_blank" title="PubMed ID 18029012" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=18029012">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0086091">involved_in regulation of heart rate by cardiac conduction</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-19-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IC</a>
<div id="evidence-code-19-1" class="ecode">Inferred by Curator<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/11953308" target="_blank" title="PubMed ID 11953308" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=11953308">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0003064">involved_in regulation of heart rate by hormone</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-20-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> NAS</a>
<div id="evidence-code-20-1" class="ecode">Non-traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/11953308" target="_blank" title="PubMed ID 11953308" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=11953308">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0060306">involved_in regulation of membrane repolarization</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-21-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-21-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/11953308" target="_blank" title="PubMed ID 11953308" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=11953308">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0007346">involved_in regulation of mitotic cell cycle</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-22-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-22-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:1901379">involved_in regulation of potassium ion transmembrane transport</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-23-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-23-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/11953308" target="_blank" title="PubMed ID 11953308" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=11953308">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0007165">involved_in signal transduction</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-24-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-24-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0021762">involved_in substantia nigra development</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-25-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> HEP</a>
<div id="evidence-code-25-1" class="ecode">
<br />
<a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a>
</div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/22926577" target="_blank" title="PubMed ID 22926577" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=22926577">PubMed</a> </td>
</tr>
</tbody>
</table>
</div>
</div>
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-config="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Component</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005737">is_active_in cytoplasm</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-1-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005737">is_active_in cytoplasm</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-2-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/11118213" target="_blank" title="PubMed ID 11118213" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=11118213">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005737">located_in cytoplasm</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-3-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/12917326" target="_blank" title="PubMed ID 12917326" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=12917326">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005829">located_in cytosol</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-4-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/31906564" target="_blank" title="PubMed ID 31906564" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=31906564">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005829">located_in cytosol</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-5-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005783">is_active_in endoplasmic reticulum</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-6-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/35343654" target="_blank" title="PubMed ID 35343654" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=35343654">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0070062">located_in extracellular exosome</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> HDA</a>
<div id="evidence-code-7-2" class="ecode">
<br />
<a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a>
</div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/19056867,19199708,20458337,23533145" target="_blank" title="PubMed ID 19056867,19199708,20458337,23533145" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=19056867,19199708,20458337,23533145">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005925">located_in focal adhesion</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> HDA</a>
<div id="evidence-code-8-2" class="ecode">
<br />
<a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a>
</div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/21423176" target="_blank" title="PubMed ID 21423176" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=21423176">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0042470">located_in melanosome</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-9-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0016020">located_in membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> HDA</a>
<div id="evidence-code-10-2" class="ecode">
<br />
<a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a>
</div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/19946888" target="_blank" title="PubMed ID 19946888" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=19946888">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0031966">is_active_in mitochondrial membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IC</a>
<div id="evidence-code-11-2" class="ecode">Inferred by Curator<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/22607805" target="_blank" title="PubMed ID 22607805" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=22607805">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005634">located_in nucleus</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-12-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-12-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/12917326,31906564" target="_blank" title="PubMed ID 12917326,31906564" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=12917326,31906564">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005886">colocalizes_with plasma membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-13-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-13-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/18029012" target="_blank" title="PubMed ID 18029012" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=18029012">PubMed</a> </td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
</div>
</div>
</div>
<div class="rprt-section gene-general-protein-info">
<section class="rprt-section-header" id="general-protein-info">
<h2 id="header-general-protein-info">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-protein-info .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">General protein information</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.General_Protein_Information" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<dl>
<dt>Preferred Names</dt>
<dd>14-3-3 protein epsilon</dd>
</dl>
<dl>
<dt>Names</dt>
<dd>14-3-3 epsilon</dd>
<dd>epididymis luminal protein 2</dd>
<dd>mitochondrial import stimulation factor L subunit</dd>
<dd>protein kinase C inhibitor protein-1</dd>
<dd>tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide</dd>
<dd>tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide</dd>
</dl>
</div>
</div>
<div class="rprt-section gene-reference-sequences">
<section class="rprt-section-header" id="reference-sequences">
<h2 id="header-reference-sequences">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-reference-sequences .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">NCBI Reference Sequences (RefSeq)</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.NCBI_Reference_Sequences_RefS" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<p>
<span class="new-icon">NEW</span>
<strong>Try the new <a href="/datasets/tables/genes/?table_type=transcripts&amp;ids=7531&amp;utm_source=gene&amp;utm_medium=referral&amp;utm_campaign=refseq" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report." data-ga-category="refseq" data-ga-action="click_datasets_link" data-ga-label="transcript_table">Transcript table</a></strong>
</p>
<h3 class="genomerefseqs gene_std_toggler" id="refseqset-independent">
<a class="jig-ncbitoggler-open">RefSeqs maintained independently of Annotated
Genomes</a>
</h3>
<div class="genomerefseqs_slave">
<p class="desc"> These reference sequences exist independently of genome builds. <a href="#refseq-expl" id="expl-refseg">Explain</a></p>
<p id="refseq-expl"> These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in <a href="#geneGenomic regions, transcripts, and products">Genomic regions,
transcripts, and products</a> above. </p>
<h4 id="genomic-p56961648">Genomic </h4>
<ol>
<li>
<p>NG_009233.1 RefSeqGene</p>
<dl>
<dt>Range</dt>
<dd class="rs-range">
<span>5041..60988</span>
</dd>
<dt>Download</dt>
<dd><a href="/nuccore/NG_009233.1?from=5041&amp;to=60988&amp;report=genbank" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=NG_009233.1?from=5041&amp;to=60988&amp;report=genbank">GenBank</a>, <a href="/nuccore/NG_009233.1?from=5041&amp;to=60988&amp;report=fasta" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=NG_009233.1?from=5041&amp;to=60988&amp;report=fasta">FASTA</a>, <a href="/nuccore/NG_009233.1?from=1&amp;to=69379&amp;report=graph&amp;content=5" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=NG_009233.1?from=1&amp;to=69379&amp;report=graph&amp;content=5">Sequence Viewer (Graphics)</a></dd>
</dl>
</li>
</ol>
<h4 id="mrnaandproteins-p147528256">mRNA and Protein(s) </h4>
<ol>
<li>
<p><a href="/nuccore/NM_006761.5">NM_006761.5</a><a href="/protein/NP_006752.1">NP_006752.1</a>  14-3-3 protein epsilon</p>
<p>
<a href="/ipg/NP_006752.1/" ref="ncbi_uid=7531">See identical proteins and their annotated locations for NP_006752.1</a>
</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Description</dt>
<dd>Transcript Variant: This variant (1) represents the protein-coding transcript.</dd>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AC032044, AY883089, DC365395">AC032044, AY883089, DC365395</a>
</dd>
<dt>Consensus CDS</dt>
<dd>
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&amp;GO=MainBrowse&amp;DATA=CCDS11001.1">CCDS11001.1</a>
</dd>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B3KY71" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=7531&amp;nlmid=&amp;db=gene">B3KY71</a>, <a href="https://www.uniprot.org/uniprot/D3DTH5" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=7531&amp;nlmid=&amp;db=gene">D3DTH5</a>, <a href="https://www.uniprot.org/uniprot/P29360" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=7531&amp;nlmid=&amp;db=gene">P29360</a>, <a href="https://www.uniprot.org/uniprot/P42655" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=7531&amp;nlmid=&amp;db=gene">P42655</a>, <a href="https://www.uniprot.org/uniprot/P62258" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=7531&amp;nlmid=&amp;db=gene">P62258</a>, <a href="https://www.uniprot.org/uniprot/Q4VJB6" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=7531&amp;nlmid=&amp;db=gene">Q4VJB6</a>, <a href="https://www.uniprot.org/uniprot/Q53XZ5" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=7531&amp;nlmid=&amp;db=gene">Q53XZ5</a>, <a href="https://www.uniprot.org/uniprot/Q63631" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=7531&amp;nlmid=&amp;db=gene">Q63631</a>, <a href="https://www.uniprot.org/uniprot/Q7M4R4" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=7531&amp;nlmid=&amp;db=gene">Q7M4R4</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/V9HW98" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=7531&amp;nlmid=&amp;db=gene">V9HW98</a>
</dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000264335.8" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=7531&amp;nlmid=&amp;db=gene">ENSP00000264335.8</a>, <a href="http://www.ensembl.org/id/ENST00000264335.13" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=7531&amp;nlmid=&amp;db=gene">ENST00000264335.13</a></dd>
<dt class="clear"> Conserved Domains (1) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_006752.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=206757">cd10020</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">4</span><span class="cddto">233</span></dt>
<dd class="clearfix"> 14-3-3_epsilon; 14-3-3 epsilon, an isoform of 14-3-3 protein</dd>
</dl>
</dd>
</dl>
</li>
</ol>
<h4 id="rna-p23711776">RNA</h4>
<ol>
<li>
<p><a href="/nuccore/NR_024058.2">NR_024058.2</a> RNA Sequence </p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Description</dt>
<dd>Transcript Variant: This variant (2) includes an alternate exon in the coding region, compared to variant 1, that contains an in-frame stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated decay (NMD).</dd>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AC032044, AY883089, DC365395">AC032044, AY883089, DC365395</a>
</dd>
<dt>Related</dt>
<dd>
<a href="http://www.ensembl.org/id/ENST00000571732.5" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=7531&amp;nlmid=&amp;db=gene">ENST00000571732.5</a>
</dd>
</dl>
</li>
</ol>
</div>
<h3 class="genomerefseqs gene_std_toggler" id="annotatedrefseq-title">
<a class="jig-ncbitoggler-open">RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08</a>
</h3>
<div class="genomerefseqs_slave">
<p class="desc"> The following sections contain reference sequences that belong to a
specific genome build. <a href="#" id="expl-genomes">Explain</a></p>
<p id="expl-genomes-desc" style="display:none">This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.</p>
<h3 id="refseq-sequencedescription-p38473200">Reference GRCh38.p14 Primary Assembly</h3>
<h4 id="genomic-p38473200">Genomic </h4>
<ol>
<li>
<p>NC_000017.11 Reference GRCh38.p14 Primary Assembly</p>
<dl>
<dt>Range</dt>
<dd class="rs-range">
<span>1344275..1400222 complement</span>
</dd>
<dt>Download</dt>
<dd><a href="/nuccore/NC_000017.11?from=1344275&amp;to=1400222&amp;report=genbank&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=NC_000017.11?from=1344275&amp;to=1400222&amp;report=genbank&amp;strand=true">GenBank</a>, <a href="/nuccore/NC_000017.11?from=1344275&amp;to=1400222&amp;report=fasta&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=NC_000017.11?from=1344275&amp;to=1400222&amp;report=fasta&amp;strand=true">FASTA</a>, <a href="/nuccore/NC_000017.11?from=1335882&amp;to=1408613&amp;report=graph&amp;content=5&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=NC_000017.11?from=1335882&amp;to=1408613&amp;report=graph&amp;content=5&amp;strand=true">Sequence Viewer (Graphics)</a></dd>
</dl>
</li>
</ol>
<h3 id="refseq-sequencedescription-p318614048">Reference GRCh38.p14 ALT_REF_LOCI_1</h3>
<h4 id="genomic-p318614048">Genomic </h4>
<ol>
<li>
<p>NT_187613.1 Reference GRCh38.p14 ALT_REF_LOCI_1</p>
<dl>
<dt>Range</dt>
<dd class="rs-range">
<span>286301..342248 complement</span>
</dd>
<dt>Download</dt>
<dd><a href="/nuccore/NT_187613.1?from=286301&amp;to=342248&amp;report=genbank&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=NT_187613.1?from=286301&amp;to=342248&amp;report=genbank&amp;strand=true">GenBank</a>, <a href="/nuccore/NT_187613.1?from=286301&amp;to=342248&amp;report=fasta&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=NT_187613.1?from=286301&amp;to=342248&amp;report=fasta&amp;strand=true">FASTA</a>, <a href="/nuccore/NT_187613.1?from=277908&amp;to=350639&amp;report=graph&amp;content=5&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=NT_187613.1?from=277908&amp;to=350639&amp;report=graph&amp;content=5&amp;strand=true">Sequence Viewer (Graphics)</a></dd>
</dl>
</li>
</ol>
<h3 id="refseq-sequencedescription-p278841120">Alternate T2T-CHM13v2.0</h3>
<h4 id="genomic-p278841120">Genomic </h4>
<ol>
<li>
<p>NC_060941.1 Alternate T2T-CHM13v2.0</p>
<dl>
<dt>Range</dt>
<dd class="rs-range">
<span>1232983..1288946 complement</span>
</dd>
<dt>Download</dt>
<dd><a href="/nuccore/NC_060941.1?from=1232983&amp;to=1288946&amp;report=genbank&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=NC_060941.1?from=1232983&amp;to=1288946&amp;report=genbank&amp;strand=true">GenBank</a>, <a href="/nuccore/NC_060941.1?from=1232983&amp;to=1288946&amp;report=fasta&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=NC_060941.1?from=1232983&amp;to=1288946&amp;report=fasta&amp;strand=true">FASTA</a>, <a href="/nuccore/NC_060941.1?from=1224588&amp;to=1297339&amp;report=graph&amp;content=5&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=NC_060941.1?from=1224588&amp;to=1297339&amp;report=graph&amp;content=5&amp;strand=true">Sequence Viewer (Graphics)</a></dd>
</dl>
</li>
</ol>
</div>
</div>
</div>
<div class="rprt-section gene-related-sequences">
<section class="rprt-section-header" id="related-sequences">
<h2 id="header-related-sequences">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-related-sequences .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Related sequences</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Related_Sequences" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<table id="proteinTblId" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/7531/data/related-sequences/',webserviceParams: 'p$l=Ajax', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
<thead>
<tr>
<th colspan="2" id="rs-nucleo">Nucleotide</th>
<th rowspan="2" id="rs-protein">Protein</th>
</tr>
<tr>
<th id="rs-heading">Heading</th>
<th id="rs-heading-acc">Accession and Version</th>
</tr>
</thead>
<tbody></tbody>
</table>
<table id="proteinTblId" class="jig-ncbigrid" data-jigconfig="isPageable:true, pageSize:25">
<thead>
<tr>
<th class="proteinTblTh" rowspan="2" id="rs-prot-acc">Protein Accession</th>
<th class="proteinTblTh" colspan="2" id="rs-link">Links</th>
</tr>
<tr>
<th id="rs-genepept">GenPept Link</th>
<th id="rs-uniprot">UniProtKB Link</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="rs-prot-acc">P62258.1</td>
<td headers="rs-link rs-genepept">
<a href="/protein/51702210" ref="ordinalpos=1&amp;ncbi_uid=7531&amp;link_uid=51702210">GenPept</a>
</td>
<td>
<a href="https://www.uniprot.org/uniprot/P62258">UniProtKB/Swiss-Prot:P62258</a>
</td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<div class="rprt-section gene-additional-links">
<section class="rprt-section-header" id="additional-links"><h2 id="header-additional-links"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-additional-links .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Additional links</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Additional_Links" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
<div class="rprt-section-body" style="">
<div id="lsdb"><h3 class="withnote" id="locusspecificdatabases"><a class="jig-ncbitoggler-open">Locus-specific Databases</a></h3><div><ul class="locusdb"><li><a href="http://databases.lovd.nl/shared/genes/YWHAE" ref="from_uid=7531" class="lsdblink">YWHAE database</a></li></ul></div></div>
<h3 class="withnote" id="genelinkout">
<a class="jig-ncbitoggler">Gene LinkOut</a>
</h3><div>
<p>The following <a href="https://www.ncbi.nlm.nih.gov/projects/linkout/index.html">LinkOut</a> resources are supplied by external providers. These providers are responsible for maintaining the links. </p>
<div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Chemical Information</span>
</a>
<ul>
<li><span class="free-rsc"></span>Interologous Interaction Database</li>
<ul>
<li>
<a target="_blank" href="http://ophid.utoronto.ca/redirect/ncbi/human?proteins=7531" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7911">
<span>Interologous Interaction Database</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>MilliporeSigma</li>
<ul>
<li>
<a target="_blank" href="https://www.sigmaaldrich.com/catalog/genes/YWHAE?lang=en&amp;region=US" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9978">
<span>Ywhae products</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Medical</span>
</a>
<ul>
<li><span class="free-rsc"></span>MedlinePlus Health Information</li>
<ul>
<li>
<a target="_blank" href="https://medlineplus.gov/genetics/gene/ywhae" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=3162">
<span>YWHAE gene</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Molecular Biology Databases</span>
</a>
<ul>
<li><span class="free-rsc"></span>Bgee database</li>
<ul>
<li>
<a target="_blank" href="https://www.bgee.org/gene/ENSG00000108953" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10418">
<span>YWHAE gene expression</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>BioGPS</li>
<ul>
<li>
<a target="_blank" href="http://biogps.org/gene/7531/" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5059">
<span>BioGPS</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>BioGRID Open Repository of CRISPR Screens (ORCS)</li>
<ul>
<li>
<a target="_blank" href="https://orcs.thebiogrid.org/Gene/7531" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10164">
<span>BioGRID CRISPR Screen Phenotypes (228 hits/1337 screens)</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Domain Mapping of Disease Mutations</li>
<ul>
<li>
<a target="_blank" href="http://bioinf.umbc.edu/DMDM/gene_prot_page.php?id=7531" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7642">
<span>YWHAE</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Eukaryotic Promoter Database</li>
<ul>
<li>
<a target="_blank" href="http://epd.vital-it.ch/cgi-bin/get_doc?db=hgEpdNew&amp;format=genome&amp;entry=YWHAE_1" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9624">
<span>YWHAE_1</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>GlyGen glycoinformatics resource</li>
<ul>
<li>
<a target="_blank" href="https://glygen.org/protein/P62258" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10227">
<span>GlyGen glycoinformatics resource</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Human eFP Browser</li>
<ul>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Circulatory_Respiratory&amp;modeInput=Absolute&amp;primaryGene=7531" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Nervous&amp;modeInput=Absolute&amp;primaryGene=7531" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Reproductive&amp;modeInput=Absolute&amp;primaryGene=7531" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
</ul>
<li>Ingenuity Pathways Analysis</li>
<ul>
<li>
<a target="_blank" href="http://partnersolution.ingenuity.com/?cid=97ae3f91eab87a&amp;p1=Entrez&amp;p2=GV&amp;s=&amp;ipaUri=%2Fpa%2Fapi%2Fv2%2Fgeneview%3Fapplicationname%3DEntrez%26geneId%3D7531%26geneidtype%3Dentrezgene" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5628">
<span>Ingenuity Pathways Analysis</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>InnateDB</li>
<ul>
<li>
<a target="_blank" href="http://www.innatedb.com/getGeneCard.do?id=14629" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7894">
<span>InnateDB</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>InterMine</li>
<ul>
<li>
<a target="_blank" href="https://www.humanmine.org/humanmine/search?keyword=ENSG00000108953" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9169">
<span>InterMine</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Kyoto Encyclopedia of Genes and Genomes</li>
<ul>
<li>
<a target="_blank" href="http://www.genome.jp/dbget-bin/www_bget?hsa:7531" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5174">
<span>Kyoto Encyclopedia of Genes and Genomes</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>OMA Browser: Orthologous MAtrix</li>
<ul>
<li>
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN30615/" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9822">
<span>OMA Browser: Orthologous MAtrix</span>
</a>
</li>
<li>
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN30617/" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9822">
<span>OMA Browser: Orthologous MAtrix</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>OrthoDB catalog of orthologs</li>
<ul>
<li>
<a target="_blank" href="https://www.orthodb.org/?ncbi=7531" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8178">
<span>Orthologs</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>PhosphoSitePlus</li>
<ul>
<li>
<a target="_blank" href="https://www.phosphosite.org/entrezGeneIdAction.action?id=7531" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7987">
<span>PhosphoSitePlus® - comprehensive post-translational modification resource</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>The Gene Wiki</li>
<ul>
<li>
<a target="_blank" href="https://en.wikipedia.org/wiki/YWHAE" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=6933">
<span>The Gene Wiki</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>The Weizmann Institute of Science GeneCards and MalaCards databases</li>
<ul>
<li>
<a target="_blank" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=YWHAE" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8598">
<span>GeneCard for YWHAE</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Research Materials</span>
</a>
<ul>
<li><span class="order-rsc"></span>Addgene Non-profit plasmid repository</li>
<ul>
<li>
<a target="_blank" href="https://addgene.org//browse/gene/7531" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5304">
<span>Get Plasmids - Addgene</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>Bio-Techne</li>
<ul>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/14-3-3-epsilon/antibodies?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=antibodies" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>14-3-3 epsilon Antibodies</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/14-3-3-epsilon/lysates?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=lysates" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>14-3-3 epsilon Lysates</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/14-3-3-epsilon/proteins-enzymes?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=proteins" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>14-3-3 epsilon Proteins</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>Creative Biogene</li>
<ul>
<li>
<a target="_blank" href="https://www.creative-biogene.com/genesearch/Ywhae.html" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10094">
<span>tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon</span>
</a>
</li>
</ul>
<li>ExactAntigen/Labome</li>
<ul>
<li>
<a target="_blank" href="https://www.labome.com/review/gene/human/14-3-3-protein-epsilon-antibody.html" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5753">
<span>reagent review</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.labome.com/gene/human/14-3-3-protein-epsilon-antibody.html" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5753">
<span>reagents</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GenScript latest version of gene cDNA ORF Clone</li>
<ul>
<li>
<a target="_blank" href="http://www.genscript.com/gene/7531" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8012">
<span>GenScript latest version of gene cDNA ORF Clone</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GeneCopoeia Inc.</li>
<ul>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=11&amp;field=5&amp;key=7531" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order shRNA clones</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=26&amp;field=5&amp;key=7531" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order TALEN/CRISPR clones</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?tax_id=9606&amp;field=5&amp;prt=16&amp;key=7531" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order miRNA target clones</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GeneTex Inc</li>
<ul>
<li>
<a target="_blank" href="https://www.genetex.com/Product/Search?geneid=7531&amp;type=03&amp;page=1" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8117">
<span>Find Recombinant Proteins and Peptides</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.genetex.com/Product/Search?geneid=7531&amp;type=01&amp;page=1" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8117">
<span>Find Quality Antibodies</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>Kazusa DNA Research Institute</li>
<ul>
<li>
<a target="_blank" href="http://www.kazusa.or.jp/kop/dsearch/symsearch.cgi?keyword=YWHAE;" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=3267">
<span>Kazusa DNA Research Institute</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>OriGene</li>
<ul>
<li>
<a target="_blank" href="https://www.origene.com/search?q=YWHAE" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7994">
<span>Order YWHAE cDNA clone/Protein/Antibody/RNAi</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Tools</span>
</a>
<ul>
<li><span class="free-rsc"></span>GeneMANIA</li>
<ul>
<li>
<a target="_blank" href="http://genemania.org/link?o=9606&amp;g=7531" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7529">
<span>GeneMANIA</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open">
<span>Miscellaneous</span>
</a>
<ul>
<li><span class="free-rsc"></span>Reactome</li>
<ul>
<li>
<a target="_blank" href="https://reactome.org/PathwayBrowser/#/R-HSA-1643685" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=4914">
<span>Reactome Event:Disease</span>
</a>
</li>
<li>
<a target="_blank" href="https://reactome.org/PathwayBrowser/#/R-HSA-74160" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=4914">
<span>Reactome Event:Gene expression (Transcription)</span>
</a>
</li>
<li>
<a target="_blank" href="https://reactome.org/PathwayBrowser/#/R-HSA-162582" ref="itool=Gene_FullReport&amp;uid=7531&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=4914">
<span>Reactome Event:Signal Transduction</span>
</a>
</li>
</ul>
</ul>
</div>
</div>
</div>
<div id="urls-in-genombrowser" style="display:none">
</div>
</div>
</div>
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document.getElementsByTagName('head')[0].appendChild(meta);
}
*/
var __ncbi_sg_pingCallbacks_render_gene = function (data, evtObj, type) {
// data looks like {jsevent: "click", "link_id": "foo", ...}
// evtObj is the JS event object
// type is either "stat" (for applog) or "ga"
var extraData = {};
if (type == "stat") {
for (var o in section_status_meta) {
extraData[o] = section_status_meta[o];
}
return extraData;
}
}
</script></div>
</div>
</div>
<div id="messagearea_bottom">
</div>
<div class=" bottom">
</div>
</div>
</div>
<div class="supplemental col three_col last" id="sidebar_tabular">
<!-- sidebar close/hide button-->
<div class="ui-helper-clearfix">
<a href="#" id="sidecontent_2_pullout" style="float:right;" class="sidecontentpullout_local collapse_button"><span>Hide sidebar &gt;&gt;</span></a>
</div>
<!-- end sidebar close/hide button-->
<h2 class="offscreen_noflow">Supplemental Content</h2>
<div id="gene-sidebar">
<div>
<div class="portlet brieflink dis-table-of-contents">
<div class="portlet_head">
<div class="portlet_title">
<h3>Table of contents</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_TableOfContents" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li class="">
<a href="#summary">Summary</a>
</li>
<li class="">
<a href="#genomic-context">Genomic context</a>
</li>
<li class="">
<a href="#genomic-regions-transcripts-products">Genomic regions, transcripts, and products</a>
</li>
<li class="">
<a href="#gene-expression">Expression</a>
</li>
<li class="">
<a href="#bibliography">Bibliography</a>
</li>
<li class="">
<a href="#phenotypes">Phenotypes</a>
</li>
<li class="">
<a href="#variation">Variation</a>
</li>
<li class="">
<a href="#HIV-1-interactions">HIV-1 interactions</a>
</li>
<li class="">
<a href="#pathways">Pathways from PubChem</a>
</li>
<li class="">
<a href="#interactions">Interactions</a>
</li>
<li class="">
<a href="#general-gene-info">General gene information</a>
<div class="subsection-links"><a href="#gene-markers">Markers</a>, <a href="#Relatedpseudogenes">Related pseudogene(s)</a>, <a href="#CloneNames">Clone Names</a>, <a href="#homology">Homology</a>, <a href="#gene-ontology">Gene Ontology</a></div>
</li>
<li class="">
<a href="#general-protein-info">General protein information</a>
</li>
<li class="">
<a href="#reference-sequences">NCBI Reference Sequences (RefSeq)</a>
</li>
<li class="">
<a href="#related-sequences">Related sequences</a>
</li>
<li class="">
<a href="#additional-links">Additional links</a>
<div class="subsection-links">
<a href="#lsdb">Locus-specific Databases</a>
</div>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-genomesbrowser brieflink dis-genomesbrowser">
<div class="portlet_head">
<div class="portlet_title">
<h3>Genome Browsers</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GenomeBrowsers.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GenomeBrowsers" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GenomeBrowsers.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="#">Loading...</a>
</li>
</ul>
</div>
</div>
<div class="portlet dis-related-info brieflink">
<div class="portlet_head">
<div class="portlet_title">
<h3>Related information</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter"></a>
</div>
<div class="portlet_content DiscoveryDbLinks">
<ul>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clone/order/gene/7531" ref="log$=recordlinks">Order cDNA clone</a>
<div class="brieflinkpop offscreen_noflow">Order cDNA clone</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/structure?LinkName=gene_structure&amp;from_uid=7531" ref="log$=recordlinks">3D structures</a>
<div class="brieflinkpop offscreen_noflow">3D structure of a gene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_alltarget_list&amp;from_uid=7531" ref="log$=recordlinks">BioAssay by Target (List)</a>
<div class="brieflinkpop offscreen_noflow">BioAssays related to the gene by protein target or RNAi target</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="//pubchem.ncbi.nlm.nih.gov/assay/bioactivity.html?geneid=7531" ref="log$=recordlinks">BioAssay by Target (Summary)</a>
<div class="brieflinkpop offscreen_noflow">Summarized PubChem Data on the gene, showing the active data by default</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_target&amp;from_uid=7531" ref="log$=recordlinks">BioAssay, by Gene target</a>
<div class="brieflinkpop offscreen_noflow">PubChem BioAssays done on the Gene target</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai&amp;from_uid=7531" ref="log$=recordlinks">BioAssays, RNAi Target, Tested</a>
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/bioproject?LinkName=gene_bioproject&amp;from_uid=7531" ref="log$=recordlinks">BioProjects</a>
<div class="brieflinkpop offscreen_noflow">BioProjects related to a gene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/biosystems?LinkName=gene_biosystems&amp;from_uid=7531" ref="log$=recordlinks">BioSystems</a>
<div class="brieflinkpop offscreen_noflow">BioSystems</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/CCDS/CcdsBrowse.cgi?REQUEST=GENEID&amp;DATA=7531" ref="log$=recordlinks">CCDS</a>
<div class="brieflinkpop offscreen_noflow">Link to CCDS</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar&amp;from_uid=7531" ref="log$=recordlinks">ClinVar</a>
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/cdd?LinkName=gene_cdd&amp;from_uid=7531" ref="log$=recordlinks">Conserved Domains</a>
<div class="brieflinkpop offscreen_noflow">Related CDD</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/dbvar?LinkName=gene_dbvar&amp;from_uid=7531" ref="log$=recordlinks">dbVar</a>
<div class="brieflinkpop offscreen_noflow">Link from Gene to dbVar</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc&amp;from_uid=7531" ref="log$=recordlinks">Full text in PMC</a>
<div class="brieflinkpop offscreen_noflow">PMC links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc_nucleotide&amp;from_uid=7531" ref="log$=recordlinks">Full text in PMC_nucleotide</a>
<div class="brieflinkpop offscreen_noflow">Full text in PubMedCentral identified from shared sequence links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/sparcle?LinkName=gene_sparcle&amp;from_uid=7531" ref="log$=recordlinks">Functional Class</a>
<div class="brieflinkpop offscreen_noflow">Functional class of the sequence domain architecture</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gene?LinkName=gene_gene_neighbors&amp;from_uid=7531" ref="log$=recordlinks">Gene neighbors</a>
<div class="brieflinkpop offscreen_noflow">Overlapping genes and two nearest non-overlapping genes on either side</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gene?LinkName=gene_gene_h3k4me3&amp;from_uid=7531" ref="log$=recordlinks">Genes with a similar H3K4me3 profile</a>
<div class="brieflinkpop offscreen_noflow">Genes with a similar profile of promoter-activating H3K4me3 modifications across several tissue types</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/genome?LinkName=gene_genome&amp;from_uid=7531" ref="log$=recordlinks">Genome</a>
<div class="brieflinkpop offscreen_noflow">Related Genome</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/geoprofiles?LinkName=gene_geoprofiles&amp;from_uid=7531" ref="log$=recordlinks">GEO Profiles</a>
<div class="brieflinkpop offscreen_noflow">Related GEO</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gtr/tests/?term=7531[geneid]" ref="log$=recordlinks">GTR</a>
<div class="brieflinkpop offscreen_noflow">Tests for this gene in the NIH Genetic Testing Registry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/homologene?LinkName=gene_homologene&amp;from_uid=7531" ref="log$=recordlinks">HomoloGene</a>
<div class="brieflinkpop offscreen_noflow">Related HomoloGene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore&amp;from_uid=7531" ref="log$=recordlinks">Nucleotide</a>
<div class="brieflinkpop offscreen_noflow">Link to related Nucleotide entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/omim?LinkName=gene_omim&amp;from_uid=7531" ref="log$=recordlinks">OMIM</a>
<div class="brieflinkpop offscreen_noflow">Link to related OMIM entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/probe?LinkName=gene_probe&amp;from_uid=7531" ref="log$=recordlinks">Probe</a>
<div class="brieflinkpop offscreen_noflow">Related Probe entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein&amp;from_uid=7531" ref="log$=recordlinks">Protein</a>
<div class="brieflinkpop offscreen_noflow">Link to related protein entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pccompound?LinkName=gene_pccompound&amp;from_uid=7531" ref="log$=recordlinks">PubChem Compound</a>
<div class="brieflinkpop offscreen_noflow">PubChem Compounds</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcsubstance?LinkName=gene_pcsubstance&amp;from_uid=7531" ref="log$=recordlinks">PubChem Substance</a>
<div class="brieflinkpop offscreen_noflow">PubChem Substances</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed&amp;from_uid=7531" ref="log$=recordlinks">PubMed</a>
<div class="brieflinkpop offscreen_noflow">Link to related PubMed entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_rif&amp;from_uid=7531" ref="log$=recordlinks">PubMed (GeneRIF)</a>
<div class="brieflinkpop offscreen_noflow">Link to related PubMed article from GeneRIFs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_citedinomim&amp;from_uid=7531" ref="log$=recordlinks">PubMed (OMIM)</a>
<div class="brieflinkpop offscreen_noflow">Gene links to PubMed derived from omim_pubmed_cited links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_pmc_nucleotide&amp;from_uid=7531" ref="log$=recordlinks">PubMed(nucleotide/PMC)</a>
<div class="brieflinkpop offscreen_noflow">Citations in PubMed identified from shared sequence and PMC links.</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein_refseq&amp;from_uid=7531" ref="log$=recordlinks">RefSeq Proteins</a>
<div class="brieflinkpop offscreen_noflow">Link to Protein RefSeqs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore_refseqrna&amp;from_uid=7531" ref="log$=recordlinks">RefSeq RNAs</a>
<div class="brieflinkpop offscreen_noflow">Link to Nucleotide RefSeq RNAs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/nuccore/219521851?report=graph" ref="log$=recordlinks">RefSeqGene</a>
<div class="brieflinkpop offscreen_noflow">Link to Nucleotide RefSeqGenes</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar_specific&amp;from_uid=7531" ref="log$=recordlinks">Related gene-specific medical variations</a>
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/snp?LinkName=gene_snp&amp;from_uid=7531" ref="log$=recordlinks">SNP</a>
<div class="brieflinkpop offscreen_noflow">Related SNP records</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/taxonomy?LinkName=gene_taxonomy&amp;from_uid=7531" ref="log$=recordlinks">Taxonomy</a>
<div class="brieflinkpop offscreen_noflow">Link to related taxonomy entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/variation/view/?q=7531[geneid]" ref="log$=recordlinks">Variation Viewer</a>
<div class="brieflinkpop offscreen_noflow">Related Variants</div>
</li>
</ul>
</div>
</div>
<div class="portlet dis-links-to-other-res brieflink">
<div class="portlet_head">
<div class="portlet_title">
<h3>Links to other resources</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_LinksTwo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12851">HGNC</a>
</li>
<li>
<a href="http://www.ensembl.org/id/ENSG00000108953">Ensembl</a>
</li>
<li>
<a href="https://www.alliancegenome.org/gene/HGNC:12851">AllianceGenome</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=geneid&amp;org=9606&amp;l=7531">AceView</a>
</li>
<li>
<a href="http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&amp;position=NR_024058">UCSC</a>
</li>
<li>
<a href="http://databases.lovd.nl/shared/genes/YWHAE">YWHAE database</a>
</li>
<li>
<a href="https://genecollections.nci.nih.gov/MGC/?ORG=Hs&amp;LIST=BC000179,BC001440">MGC</a>
</li>
<li>
<a href="https://phgkb.cdc.gov/PHGKB/huGEPedia.action?firstQuery=YWHAE&amp;geneID=7531&amp;typeOption=gene&amp;which=2&amp;pubOrderType=pubD&amp;typeSubmit=GO&amp;check=y">HuGE Navigator</a>
</li>
<li>
<a href="http://www.genome.jp/dbget-bin/www_bget?hsa:7531">KEGG</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-general-info">
<div class="portlet_head">
<div class="portlet_title">
<h3>General information</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GeneralInfo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="/pmc/?term=PMC4383897+OR+PMC3013746+OR+PMC1761442+OR+PMC539985">About Gene</a>
</li>
<li>
<a href="/books/NBK3840">FAQ</a>
</li>
<li>
<a href="https://ftp.ncbi.nlm.nih.gov/gene/">FTP site</a>
</li>
<li>
<a href="/books/NBK3841/">Help</a>
</li>
<li>
<a href="/books/NBK3842/">My NCBI help</a>
</li>
<li>
<a href="/books/NBK21085/">NCBI Handbook</a>
</li>
<li>
<a href="/gene/statistics/">Statistics</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-related-sites">
<div class="portlet_head">
<div class="portlet_title">
<h3>Related sites</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_RelatedSites" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://www.ncbi.nlm.nih.gov/BLAST">BLAST</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/genome">Genome</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/bioproject">BioProject</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/genome/gdv/">Genome Data Viewer</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/geo">GEO</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/omim">OMIM</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/probe">Probe</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/RefSeq">RefSeq</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-feedback">
<div class="portlet_head">
<div class="portlet_title">
<h3>Feedback</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_Feedback" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://support.ncbi.nlm.nih.gov/ics/support/ticketnewwizard.asp?style=classic&amp;deptID=28049">Contact Help Desk</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/RefSeq/update.cgi?geneid=7531&amp;symbol=YWHAE">Submit Correction</a>
</li>
<li>
<a href="/gene/submit-generif?geneId=7531&amp;sym=YWHAE&amp;name=tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon&amp;org=Homo sapiens">Submit GeneRIF</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-subscription">
<div class="portlet_head">
<div class="portlet_title">
<h3>Subscription</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Subscription.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_Subscription" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Subscription.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://www.ncbi.nlm.nih.gov/mailman/listinfo/refseq-announce">RefSeq</a>
</li>
</ul>
</div>
</div>
</div>
<!-- <component id="Gene_RVFullReport.Gene_RightColMenuLinks"/>-->
<div class="portlet">
<div class="portlet_head">
<div class="portlet_title">
<h3>Recent activity</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="recent_activity" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.Shutter"></a>
</div>
<div class="portlet_content">
<div id="HTDisplay" class="">
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.Cmd" sid="1" type="hidden" />
<div class="action">
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.ClearHistory" sid="1" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.ClearHistory" cmd="ClearHT" href="?cmd=ClearHT&amp;" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.ClearHistory">
Clear
</a>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" sid="1" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOn" cmd="HTOff" href="?cmd=HTOff&amp;" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle">
Turn Off
</a>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" sid="2" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOff" cmd="HTOn" href="?cmd=HTOn&amp;" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle">
Turn On
</a>
</div>
<ul id="activity">
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67c9e8b4b15b832ebc3e5fc2">YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eps...</a>
<div class="ralinkpop offscreen_noflow">YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:7531</div></div>
<div class="tertiary">Gene</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67c9e8b2b15b832ebc3e5432">14-3-3 protein epsilon [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">14-3-3 protein epsilon [Homo sapiens]<div class="brieflinkpopdesc">gi|5803225|ref|NP_006752.1|</div></div>
<div class="tertiary">Protein</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67c9e8b1f4a390645e6d034f">YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein bet...</a>
<div class="ralinkpop offscreen_noflow">YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:7529</div></div>
<div class="tertiary">Gene</div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67c9e8af84f3725e596c1ced">14-3-3 protein beta/alpha [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">14-3-3 protein beta/alpha [Homo sapiens]<div class="brieflinkpopdesc">gi|4507949|ref|NP_003395.1|</div></div>
<div class="tertiary">Protein</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67c9e8ada68b6b5afca24f43">YBX1 Y-box binding protein 1 [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">YBX1 Y-box binding protein 1 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:4904</div></div>
<div class="tertiary">Gene</div>
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