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<h1 class="res_name"><a href="/gene/">Gene</a></h1>
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<h2 class="res_tagline">Genes and mapped phenotypes</h2>
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<div class="search"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="pubmed">PubMed</option><option value="clinvar">ClinVar</option><option value="medgen">MedGen</option><option value="books" class="last">Books</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly" data-ac_dict="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene" selected="selected" data-ac_dict="gene">Gene</option><option value="genome" data-ac_dict="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen">MedGen</option><option value="mesh">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore" data-ac_dict="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein" data-ac_dict="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search Gene. Use up and down arrows to choose an item from the autocomplete." value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="dictionary:'gene',disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'yes',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div><ul class="searchlinks inline_list"><set></set><li><a href="/gene/advanced">Advanced</a></li><li class="help"><a id="help" class="jig-ncbihelpwindow" target="ncbihelp" name="help" href="/books/NBK3841/">Help</a></li></ul></div>
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<input name="EntrezSystem2.PEntrez.Gene.Gene_PageController.PreviousPageName" sid="1" type="hidden" value="results" />
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<div id="faceted_search" class="facet_hide">
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<h2 class="offscreen_noflow">Result Filters</h2>
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<div class="facet_cont" data-db="gene" data-default_grps="fg_gene-sources,fg_categories,fg_sequence-content,fg_status" data-sd="db:'gene',op:'select',term:'',qk:'4690',linkname:'',idsfromresult:'684',extra:''"><ul class="facet" data-filter_id="gene-sources" id="_gene-sources"><li class="filter_grp "><div class="clearfix"><h3>Gene sources</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="genomic">Genomic</a></li></ul></li></ul><ul class="facet" data-filter_id="categories" id="_categories"><li class="filter_grp "><div class="clearfix"><h3>Categories</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="annotated-genes">Annotated genes</a></li><li class="fil_val"><a href="#" data-value_id="gene-type-protein-coding">Protein-coding</a></li></ul></li></ul><ul class="facet" data-filter_id="sequence-content" id="_sequence-content"><li class="filter_grp "><div class="clearfix"><h3>Sequence content</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="seq-ccds">CCDS</a></li><li class="fil_val"><a href="#" data-value_id="seq-ensembl">Ensembl</a></li><li class="fil_val"><a href="#" data-value_id="refseq">RefSeq</a></li></ul></li></ul><ul class="facet" data-filter_id="status" id="_status"><li class="filter_grp "><div class="clearfix"><h3>Status</h3><a href="#" data-value_id="" class="clear clear_show">Clear</a></div><ul><li class="fil_val selected"><a href="#" data-value_id="current-only">Current</a><span class="fcount">(1)</span></li></ul></li></ul><div id="chr-location-facet-wrapper" data-bid="MCID_67c9e939d74f676910431ad6" data-hid="MCID_67c90f2d64f30b25346ccae2" data-qky="4690" class="disabled" style="display:none"><ul class="facet" data-filter_id="chromosomal-region" id="_chromosomal-region" data-of="yes"><li class="filter_grp of_grp"><div class="clearfix"><h3>Chromosome locations</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><a id="facet_ofchromosomal-region" href="#facet_of_divchromosomal-region" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'middle left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '375px'" data-value_id="fetch_more">more...</a><div id="facet_of_divchromosomal-region" style="display:none;" class="of_popup"><h4>Chromosome locations</h4><label for="organism-filter" style="width:100%;margin-bottom:.2em;" class="">Select an organism by typing or scrolling</label><input type="text" placeholder="Enter text to narrow down the list" id="organism-filter" style="width:98%;" autocomplete="off" /><br /><div id="chr-region-tax-list"><select id="of_chromosomal-region" size="9" class="chr-region-tax-list" style="width:100%;"></select></div><div id="chr-location-info-ctrl" data-disabled="disabled"><div class="chr-field"><label for="chr-name">Chromosome</label><br /><select id="chr-name" class="chr-field" disabled="disabled"></select></div><div class="chr-field"><label for="chr-from">From</label><br /><input type="text" name="chr-from" id="chr-from" disabled="disabled" class="chr-field" /></div><div class="chr-field"><label for="chr-to">To</label><br /><input type="text" name="chr-to" id="chr-to" disabled="disabled" class="chr-field" /></div></div><div class="actions clearfix"><button class="jig-ncbibutton of_add apply-chr" data-jigconfig="'color': 'ui-ncbibutton-blue'">Apply</button></div></div></ul></li></ul></div><ul class="facet facet_reset"><li><a href="#" data-value_id="reset">Clear all</a></li></ul><ul class="facet_tools"><li><a id="more_filter_groups_link" href="#more_filter_groups" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'top left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '180px'">
|
||
Show additional filters</a></li><div id="more_filter_groups" style="display:none;" class="facets_dialog"><button class="ui-ncbipopper-close-button ui-ncbipopper-close-button-generated ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-blue" generated="true" role="button" aria-disabled="false"><span class="ui-button-text">x</span></button><h4>Additional filters</h4><ul class="filter_groups_more facet"><li><input type="checkbox" id="fg_gene-sources" /><label for="fg_gene-sources">Gene sources</label></li><li><input type="checkbox" id="fg_categories" /><label for="fg_categories">Categories</label></li><li><input type="checkbox" id="fg_sequence-content" /><label for="fg_sequence-content">Sequence content</label></li><li><input type="checkbox" id="fg_status" /><label for="fg_status">Status</label></li><li><input type="checkbox" id="fg_chromosomal-region" /><label for="fg_chromosomal-region">Chromosome locations</label></li><li><input id="fg_field_search" type="checkbox" /><label for="fg_field_search">Search fields</label></li></ul><div class="actions clearfix"><button class="filter_groups_more_apply jig-ncbibutton primary-action" id="filter_groups_apply" data-jigconfig="'color': 'ui-ncbibutton-blue'">Show</button></div></div></ul><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetsUrlFrag" sid="1" type="hidden" value="filters=current-only" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetSubmitted" sid="1" type="hidden" value="false" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.BMFacets" sid="1" type="hidden" value="" /></div>
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<span style="display: block; text-align: center;">S</span>
|
||
<span style="display: block; text-align: center;">I</span>
|
||
<span style="display: block; text-align: center;">D</span>
|
||
<span style="display: block; text-align: center;">E</span>
|
||
<span style="display: block; text-align: center;">B</span>
|
||
<span style="display: block; text-align: center;">A</span>
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<span style="display: block; text-align: center;">R</span>
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|
||
<div class="results_settings one_setting"><ul class="inline_list left display_settings"><li><a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Display" sid="0" href="#" class="jig-ncbipopper" data-jigconfig="triggerPosition : 'bottom center',destPosition : 'top center',destSelector : '#display_settings_menu_report', hasArrow : false,openEvent : 'click',closeEvent : 'click',isTriggerElementCloseClick: false,addCloseButton : false, groupName: 'entrez_pg'" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Display">Full Report<span href="#" class="tgt_dark"></span></a></li></ul><div id="display_settings_menu_report" class="disp_settings tabPopper"><fieldset class="format"><legend>Format</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="1" value="full_report" format="" id="full_report" checked="true" /><label for="full_report">Full Report</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="2" value="full_report" format="text" id="full_reporttext" /><label for="full_reporttext">Full Report (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="3" value="expression" format="" id="expression" /><label for="expression">Expression</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="4" value="gene_table" format="" id="gene_table" /><label for="gene_table">Gene Table</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="5" value="gene_table" format="text" id="gene_tabletext" /><label for="gene_tabletext">Gene Table (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="6" value="generif" format="" id="generif" /><label for="generif">GeneRIF</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="7" value="docsum" format="" id="docsum" /><label for="docsum">Summary</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="8" value="docsum" format="text" id="docsumtext" /><label for="docsumtext">Summary (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="9" value="tabular" format="" id="tabular" /><label for="tabular">Tabular</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="10" value="tabular" format="text" id="tabulartext" /><label for="tabulartext">Tabular (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="11" value="asn1" format="text" id="asn1text" /><label for="asn1text">ASN.1</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="12" value="xml" format="text" id="xmltext" /><label for="xmltext">XML</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="13" value="uilist" format="text" id="uilisttext" /><label for="uilisttext">UI List</label></li></ul></fieldset></div><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SetDisplay" sid="1" class="button_apply ncbipopper-close-button" style="display:none">Apply</button><h4 class="content_header send_to align_right jig-ncbipopper" id="sendto" data-jigconfig="triggerPosition:'bottom center', destPosition : 'top center',destSelector : '#send_to_menu', hasArrow : false, openEvent : 'click',closeEvent : 'click', isTriggerElementCloseClick: false, addCloseButton:true, groupName: 'entrez_pg', adjustFit:'none'"><a href="#" sourceContent="send_to_menu" class="tgt_dark">Send to:</a><script type="text/javascript">
|
||
jQuery(document).ready( function () {
|
||
jQuery("#send_to_menu input[type='radio']").click( function () {
|
||
var selectedValue = jQuery(this).val().toLowerCase();
|
||
var selectedDiv = jQuery("#send_to_menu div." + selectedValue);
|
||
|
||
if(selectedDiv.is(":hidden")){
|
||
jQuery("#send_to_menu div.submenu:visible").slideUp();
|
||
selectedDiv.slideDown();
|
||
}
|
||
});
|
||
|
||
});
|
||
|
||
jQuery("#sendto").bind("ncbipopperclose", function(){
|
||
jQuery("#send_to_menu div.submenu:visible").css("display","none");
|
||
jQuery("#send_to_menu input[type='radio']:checked").attr("checked",false);
|
||
});
|
||
|
||
</script></h4><div id="send_to_menu" class="tabPopper send_to"><fieldset><legend>Choose Destination</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendTo" sid="1" value="File" id="dest_File" /><label for="dest_File">File</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendTo" sid="2" value="AddToClipboard" id="dest_AddToClipboard" /><label for="dest_AddToClipboard">Clipboard</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendTo" sid="3" value="AddToCollections" id="dest_AddToCollections" /><label for="dest_AddToCollections">Collections</label></li></ul></fieldset><div class="submenu file" id="submenu_File" style="display: none;"><p id="submenu_File_hint" class="hidden"></p><ul><li><label for="file_format">Format</label><select id="file_format" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.FFormat" sid="1"><option value="full_report" format="text" selected="selected">Full Report (text)</option><option value="gene_table" format="text">Gene Table (text)</option><option value="docsum" format="text">Summary (text)</option><option value="tabular" format="text">Tabular (text)</option><option value="asn1" format="text">ASN.1</option><option value="xml" format="text">XML</option><option value="uilist" format="text">UI List</option></select></li></ul><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendToSubmit" sid="1" class="button_apply file ncbipopper-close-button" type="submit" cmd="File">Create File</button></div><div class="submenu addtoclipboard" id="submenu_AddToClipboard" style="display: none;"><p id="submenu_AddToClipboard_hint" class="hidden"></p><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendToSubmit" sid="2" class="button_apply clipboard ncbipopper-close-button" type="submit" cmd="AddToClipboard">Add to Clipboard</button></div><div class="submenu addtocollections" id="submenu_AddToCollections" style="display: none;"><p id="submenu_AddToCollections_hint" class="hidden"></p><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendToSubmit" sid="3" class="button_apply collections ncbipopper-close-button" type="submit" cmd="AddToCollections">Add to Collections</button></div></div><div><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.FileFormat" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastPresentation" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Presentation" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastPageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Sort" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastSort" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.FileSort" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Format" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastFormat" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PrevPageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PrevPresentation" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PrevSort" sid="1" type="hidden" value="" /><input type="hidden" id="coll_startindex" name="CollectionStartIndex" value="1" /></div></div>
|
||
<div>
|
||
|
||
|
||
|
||
</div>
|
||
<div class="">
|
||
<div><span id="result_sel" class="nowrap"></span><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_ResultsController.ResultCount" sid="1" type="hidden" id="resultcount" value="1" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_ResultsController.RunLastQuery" sid="1" type="hidden" /></div>
|
||
|
||
</div>
|
||
<div id="messagearea" class="empty">
|
||
|
||
|
||
|
||
|
||
</div>
|
||
<div class="rprt full-rprt">
|
||
<div>
|
||
<div class="rprt-header">
|
||
<input type="hidden" id="gene-tax-id" value="9606" />
|
||
<h1 class="title" id="gene-name"><span class="gn" style="padding-right:.5em;">BST2</span> bone marrow stromal cell antigen 2 [ <em class="tax">Homo sapiens</em> (human)
|
||
]
|
||
</h1>
|
||
<span class="geneid">Gene ID: 684, updated on
|
||
4-Mar-2025</span>
|
||
</div>
|
||
<div class="download-datasets">
|
||
<script type="text/javascript" src="https://cdnjs.cloudflare.com/ajax/libs/axios/0.23.0/axios.min.js"></script>
|
||
<h4 class="download-datasets-popper jig-ncbipopper" id="download-asm" style="align-self:start" data-jigconfig="triggerPosition:'bottom center', destPosition : 'top center',destSelector : '#download-datasets-popper-menu', hasArrow : false, openEvent : 'click',closeEvent : 'click', isTriggerElementCloseClick: false, groupName: 'entrez_pg', adjustFit:'none'" role="button" aria-expanded="false" aria-haspopup="true">
|
||
<svg alt="download" class="dlbtn-icon" x="0px" y="0px" width="15px" height="15px" viewBox="0 0 60 60" enable-background="new 0 0 60 60" xml:space="preserve">
|
||
<g>
|
||
<polygon points="48.75,36.25 48.75,48.75 11.25,48.75 11.25,36.25 5,36.25 5,55 55,55 55,36.25 "></polygon>
|
||
<polygon points="42.5,23.75 36.25,23.75 36.25,5 23.75,5 23.75,23.75 17.5,23.75 30,42.5 "></polygon>
|
||
</g>
|
||
</svg>
|
||
<a href="#">Download Datasets</a>
|
||
</h4>
|
||
<div id="download-datasets-popper-menu" style="display:none;">
|
||
<div class="input-group">
|
||
<input type="checkbox" id="datasets-ft-gene-seq-fasta" value="FASTA_GENE" checked="checked" class="download-datasets-included-seq" />
|
||
<label for="datasets-ft-gene-seq-fasta">Gene Sequences (FASTA)</label>
|
||
</div>
|
||
<div class="input-group">
|
||
<input type="checkbox" id="datasets-ft-transcript-seq-fasta" value="FASTA_RNA" class="download-datasets-included-seq" />
|
||
<label for="datasets-ft-transcript-seq-fasta">Transcript sequences (FASTA)</label>
|
||
</div>
|
||
<div class="input-group">
|
||
<input type="checkbox" id="datasets-ft-protein-seq-fasta" value="FASTA_PROTEIN" class="download-datasets-included-seq" />
|
||
<label for="datasets-ft-protein-seq-fasta">Protein sequences(FASTA)</label>
|
||
</div>
|
||
<p style="margin-left:5px;">In addition, your package will include a detailed data report in both TSV and JSONL formats.</p>
|
||
<div class="input-group">
|
||
<label for="datasets-download-file-name">File name</label>
|
||
<input type="text" id="datasets-download-file-name" placeholder="Name your file" style="padding:5px;" value="BST2_datasets.zip" />
|
||
</div>
|
||
<input type="hidden" id="download-datasets-base-url" value="https://api.ncbi.nlm.nih.gov/datasets/v2alpha/gene/download" />
|
||
<input type="hidden" id="gene-id-value" value="684" />
|
||
<button id="datasets-download-submit" data-ga-action="click_begin_download" data-ga-label="download" class="jig-ncbibutton ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-gray" role="button">
|
||
<span class="ui-button-text">Download</span>
|
||
</button>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-body">
|
||
|
||
|
||
<div class="rprt-section gene-summary">
|
||
<section class="rprt-section-header" id="summary">
|
||
<h2 id="header-summary">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-summary .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Summary</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Summary_2" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div id="summaryDiv" class="section">
|
||
<dl id="summaryDl">
|
||
<dt class="noline"> Official
|
||
Symbol</dt>
|
||
<dd class="noline">BST2<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
|
||
<dt> Official
|
||
Full Name</dt>
|
||
<dd>bone marrow stromal cell antigen 2<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
|
||
<dt>Primary source</dt>
|
||
<dd>
|
||
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1119" data-gblink-text="Ensembl">HGNC:HGNC:1119</a>
|
||
</dd>
|
||
<dt>See related</dt>
|
||
<dd>
|
||
<a href="http://www.ensembl.org/id/ENSG00000130303" data-gblink-text="Ensembl" class="genome-browser-link" data-genome-browser-link-sort="5" data-gb-url="http://www.ensembl.org/loc/ENSG00000130303">Ensembl:ENSG00000130303</a>
|
||
<a href="https://www.ncbi.nlm.nih.gov/omim/600534" data-gblink-text="Ensembl" ref="ordinalpos=1&ncbi_uid=684&link_uid=600534">MIM:600534;</a>
|
||
<a href="https://www.alliancegenome.org/gene/HGNC:1119" data-gblink-text="Ensembl" ref="ordinalpos=1&ncbi_uid=684&link_uid=HGNC:1119">AllianceGenome:HGNC:1119</a>
|
||
</dd>
|
||
<dt>Gene type</dt>
|
||
<dd>protein coding</dd>
|
||
<dt>RefSeq status</dt>
|
||
<dd>REVIEWED</dd>
|
||
<dt>Organism</dt>
|
||
<dd class="tax">
|
||
<a href="/Taxonomy/Browser/wwwtax.cgi?id=9606" ref="ordinalpos=1&ncbi_uid=684&link_uid=9606">Homo sapiens</a>
|
||
</dd>
|
||
<dt>Lineage</dt>
|
||
<dd class="tax">Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo</dd>
|
||
<dt>Also known as</dt>
|
||
<dd>CD317; HM1.24; TETHERIN</dd>
|
||
<dt>Summary</dt>
|
||
<dd>Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis. [provided by RefSeq, Jul 2008]</dd>
|
||
<dt>Expression</dt>
|
||
<dd>Broad expression in ovary (RPKM 235.4), adrenal (RPKM 135.4) and 22 other tissues <a href="#gene-expression">See more</a></dd>
|
||
<dt>Orthologs</dt>
|
||
<dd class="ortholog-links">
|
||
<a href="https://www.ncbi.nlm.nih.gov/gene/69550">mouse</a>
|
||
<a href="/gene/684/ortholog/">all</a>
|
||
</dd>
|
||
<dt style="padding-top:.5em;">
|
||
<span class="new-icon">NEW</span>
|
||
</dt>
|
||
<dd style="padding-top:.5em;">
|
||
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/684/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="gene_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Gene table</a></strong>
|
||
<br />
|
||
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/684/products/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="transcript_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Transcript table</a></strong>
|
||
</dd>
|
||
</dl>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-genomic-context">
|
||
<section class="rprt-section-header" id="genomic-context">
|
||
<h2 id="header-genomic-context">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-context .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Genomic context</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Genomic_Context" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div class="gc_cont">
|
||
<div class="gt_cont_contents">
|
||
<div style="float:right"><span>See BST2 in </span><a href="/genome/gdv/?context=gene&acc=684" class="link-to-gdv genome-browser-link" data-genome-browser-link-sort="1" data-acc="GCF_000001405.40">Genome Data Viewer</a> </div>
|
||
<dl class="dl-chr-info" style="float:left;margin-top:0;">
|
||
<dt>Location: </dt>
|
||
<dd>
|
||
<span style="display:inline-block;">19p13.11</span>
|
||
</dd>
|
||
</dl>
|
||
</div>
|
||
<dl class="dl-chr-info exon-count">
|
||
<dt>Exon count: </dt>
|
||
<dd>5</dd>
|
||
</dl>
|
||
<div class="ui-ncbigrid-outer-div" id="genomic-context-tbl-location">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-jigconfig="">
|
||
<thead>
|
||
<tr>
|
||
<th style="max-width:15%">Annotation release</th>
|
||
<th style="max-width:10%">Status</th>
|
||
<th>Assembly</th>
|
||
<th>
|
||
<span title="Chromosome">Chr</span>
|
||
</th>
|
||
<th>Location</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td>RS_2024_08</td>
|
||
<td>current</td>
|
||
<td>GRCh38.p14 (<a href="/assembly/GCF_000001405.40/" ref="ncbi_uid=684&link_uid=GCF_000001405.40">GCF_000001405.40</a>)</td>
|
||
<td>19</td>
|
||
<td>NC_000019.10 (17402939..17405630, complement) </td>
|
||
</tr>
|
||
<tr>
|
||
<td>RS_2024_08</td>
|
||
<td>current</td>
|
||
<td>T2T-CHM13v2.0 (<a href="/assembly/GCF_009914755.1/" ref="ncbi_uid=684&link_uid=GCF_009914755.1">GCF_009914755.1</a>)</td>
|
||
<td>19</td>
|
||
<td>NC_060943.1 (17537665..17540365, complement) </td>
|
||
</tr>
|
||
<tr>
|
||
<td>RS_2024_09</td>
|
||
<td>previous assembly</td>
|
||
<td>GRCh37.p13 (<a href="/assembly/GCF_000001405.25/" ref="ncbi_uid=684&link_uid=GCF_000001405.25">GCF_000001405.25</a>)</td>
|
||
<td>19</td>
|
||
<td>NC_000019.9 (17513748..17516439, complement) </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<p class="withnote margin_t2em"><strong>Chromosome 19 - NC_000019.10</strong><img usemap="#nbrMap684_568815579" border="0" alt="Genomic Context describing neighboring genes" src="/gutils/geneneighb.fcgi?geneid=684&nuc_gi=568815579&n0=LOC105372298&n1=LOC127890778&n2=CCDC194&n3=LOC130063930&n4=LOC130063931&n5=LOC116276507&n6=BST2&n7=LOC129664386&n8=LOC127890779&n9=LOC130063932&n10=LOC130063933&n11=BISPR&n12=MVB12A&n13=LOC130063934&n14=LOC130063935&n15=LOC130063936&n16=LOC127890780&n17=LOC127890781&n18=HMGB3P29" /><map name="nbrMap684_568815579" id="nbrMap684_568815579">
|
||
<area shape="rect" onMouseOver="showtip(this,event,'uncharacterized LOC105372298')" onMouseOut="hidetip()" coords="2,23,72,31" alt="Neighboring gene uncharacterized LOC105372298" href="/gene/105372298" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr19:17489969-17490857')" onMouseOut="hidetip()" coords="5,35,75,43" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17489969-17490857" href="/gene/127890778" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'coiled-coil domain containing 194')" onMouseOut="hidetip()" coords="92,23,183,31" alt="Neighboring gene coiled-coil domain containing 194" href="/gene/110806280" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 10341')" onMouseOut="hidetip()" coords="97,35,167,43" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10341" href="/gene/130063930" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 10342')" onMouseOut="hidetip()" coords="99,47,169,55" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10342" href="/gene/130063931" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'CRISPRi-validated cis-regulatory element chr19.2705')" onMouseOut="hidetip()" coords="158,59,228,67" alt="Neighboring gene CRISPRi-validated cis-regulatory element chr19.2705" href="/gene/116276507" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'ReSE screen-validated silencer GRCh37_chr19:17513926-17514094')" onMouseOut="hidetip()" coords="190,23,260,31" alt="Neighboring gene ReSE screen-validated silencer GRCh37_chr19:17513926-17514094" href="/gene/129664386" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17515618-17516356')" onMouseOut="hidetip()" coords="203,35,273,43" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17515618-17516356" href="/gene/127890779" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 14267')" onMouseOut="hidetip()" coords="208,47,278,55" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14267" href="/gene/130063932" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 14268')" onMouseOut="hidetip()" coords="209,71,279,79" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14268" href="/gene/130063933" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 14269')" onMouseOut="hidetip()" coords="214,83,284,91" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14269" href="/gene/130063934" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 14270')" onMouseOut="hidetip()" coords="215,95,285,103" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14270" href="/gene/130063935" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 14271')" onMouseOut="hidetip()" coords="216,107,286,115" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14271" href="/gene/130063936" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr19:17518151-17518677')" onMouseOut="hidetip()" coords="222,119,292,127" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17518151-17518677" href="/gene/127890780" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'multivesicular body subunit 12A')" onMouseOut="hidetip()" coords="240,59,423,67" alt="Neighboring gene multivesicular body subunit 12A" href="/gene/93343" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'BST2 interferon stimulated positive regulator')" onMouseOut="hidetip()" coords="244,143,349,151" alt="Neighboring gene BST2 interferon stimulated positive regulator" href="/gene/105221694" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:17525723-17526510')" onMouseOut="hidetip()" coords="281,23,351,31" alt="Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:17525723-17526510" href="/gene/127890781" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'high mobility group box 3 pseudogene 29')" onMouseOut="hidetip()" coords="317,35,369,43" alt="Neighboring gene high mobility group box 3 pseudogene 29" href="/gene/100420015" />
|
||
</map>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-genomic-regions-transcripts-products">
|
||
<section class="rprt-section-header" id="genomic-regions-transcripts-products">
|
||
<h2 id="header-genomic-regions-transcripts-products">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-regions-transcripts-products .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Genomic regions, transcripts, and products</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Genomic_Regions_Transcripts_a" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div>
|
||
<div style="text-align:right;">Go to <a href="#reference-sequences">reference sequence details</a></div>
|
||
</div>
|
||
<div>
|
||
<p class="choose">
|
||
<label for="accession" class="label">Genomic Sequence: </label>
|
||
<select name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.accessionList" sid="1" id="accessionList" data-taxid="9606" data-geneid="684">
|
||
<option value="NC_000019.10_17402938_17405629">NC_000019.10 Chromosome 19 Reference GRCh38.p14 Primary Assembly</option>
|
||
<option value="NC_060943.1_17537664_17540364">NC_060943.1 Chromosome 19 Alternate T2T-CHM13v2.0</option>
|
||
<option value="NC_000019.9_17513747_17516438">NC_000019.9 Chromosome 19 Reference GRCh37.p13 Primary Assembly</option>
|
||
</select>
|
||
</p>
|
||
</div>
|
||
<div id="NC_000019" class="divAccession">
|
||
<div class="seq-viewer">
|
||
<p class="note-link">
|
||
<strong>Go to nucleotide:</strong>
|
||
<a title="Nucleotide Graphic report" href="/nuccore/NC_000019.10?report=graph&from=17402534&to=17406033&strand=true&app_context=Gene&assm_context=GCF_000001405.40" ref="ordinalpos=1&ncbi_uid=684&link_uid=NC_000019.10">Graphics</a>
|
||
<a title="Nucleotide FASTA report" href="/nuccore/NC_000019.10?report=fasta&from=17402939&to=17405630&strand=true" ref="ordinalpos=1&ncbi_uid=684&link_uid=NC_000019.10">FASTA</a>
|
||
<a title="Nucleotide GenBank report" href="/nuccore/NC_000019.10?report=genbank&from=17402939&to=17405630&strand=true" ref="ordinalpos=1&ncbi_uid=684&link_uid=NC_000019.10">GenBank</a>
|
||
</p>
|
||
<div id="divNC_000019" class="SeqViewerApp" style="clear:both;" data-sv="appname=ncbigene&embedded=true&noslider=1&id=NC_000019.10&from=17402534&to=17406033&strand=true&app_context=Gene&assm_context=GCF_000001405.40">
|
||
<a href="?appname=ncbigene&embedded=true&noslider=1&id=NC_000019.10&from=17402534&to=17406033&strand=true&app_context=Gene&assm_context=GCF_000001405.40"></a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000019.10" sid="1" type="hidden" id="nucleotideLink_NC_000019_10_17402938_17405629" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NC_000019.10?report=graph&amp;from=17402534&amp;to=17406033&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" ref="ordinalpos=1&amp;ncbi_uid=684&amp;link_uid=NC_000019.10">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NC_000019.10?report=fasta&amp;from=17402939&amp;to=17405630&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=684&amp;link_uid=NC_000019.10">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NC_000019.10?report=genbank&amp;from=17402939&amp;to=17405630&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=684&amp;link_uid=NC_000019.10">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000019.10" sid="1" type="hidden" id="relString_NC_000019_10_17402938_17405629" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000019.10&amp;from=17402534&amp;to=17406033&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_060943.1" sid="1" type="hidden" id="nucleotideLink_NC_060943_1_17537664_17540364" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NC_060943.1?report=graph&amp;from=17537259&amp;to=17540769&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_009914755.1" ref="ordinalpos=1&amp;ncbi_uid=684&amp;link_uid=NC_060943.1">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NC_060943.1?report=fasta&amp;from=17537665&amp;to=17540365&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=684&amp;link_uid=NC_060943.1">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NC_060943.1?report=genbank&amp;from=17537665&amp;to=17540365&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=684&amp;link_uid=NC_060943.1">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_060943.1" sid="1" type="hidden" id="relString_NC_060943_1_17537664_17540364" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_060943.1&amp;from=17537259&amp;to=17540769&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_009914755.1" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000019.9" sid="1" type="hidden" id="nucleotideLink_NC_000019_9_17513747_17516438" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NC_000019.9?report=graph&amp;from=17513343&amp;to=17516842&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.25" ref="ordinalpos=1&amp;ncbi_uid=684&amp;link_uid=NC_000019.9">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NC_000019.9?report=fasta&amp;from=17513748&amp;to=17516439&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=684&amp;link_uid=NC_000019.9">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NC_000019.9?report=genbank&amp;from=17513748&amp;to=17516439&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=684&amp;link_uid=NC_000019.9">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000019.9" sid="1" type="hidden" id="relString_NC_000019_9_17513747_17516438" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000019.9&amp;from=17513343&amp;to=17516842&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.25" />
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-gene-expression">
|
||
<section class="rprt-section-header" id="gene-expression">
|
||
<h2 id="header-gene-expression">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-gene-expression .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Expression</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Expression" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div>
|
||
<div style="text-align:right;">
|
||
<a href="/gene/684/?report=expression" data-url="/gene/684/?report=expression" id="gene-expression-see-details">See details</a>
|
||
</div>
|
||
<div id="gene-expression-app" data-url="https://www.ncbi.nlm.nih.gov/gene/684" data-report-type="summary">
|
||
<div>
|
||
<script type="text/javascript">
|
||
|
||
window.tissues_data = {'adrenal 10wk': {'id': '684_Adrenal_10wk_PRJNA270632', 'gene': 684, 'source_name': 'adrenal 10wk', 'full_rpkm': 2.63249, 'exp_rpkm': 2.63, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388696219680}, 'adrenal 16wk': {'id': '684_Adrenal_16wk_PRJNA270632', 'gene': 684, 'source_name': 'adrenal 16wk', 'full_rpkm': 10.5393, 'exp_rpkm': 10.5, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388696219681}, 'adrenal 18wk': {'id': '684_Adrenal_18wk_PRJNA270632', 'gene': 684, 'source_name': 'adrenal 18wk', 'full_rpkm': 23.3842, 'exp_rpkm': 23.4, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388696219682}, 'adrenal 20wk': {'id': '684_Adrenal_20wk_PRJNA270632', 'gene': 684, 'source_name': 'adrenal 20wk', 'full_rpkm': 23.6603, 'exp_rpkm': 23.7, 'var': 3.97068, 'project_desc': 'PRJNA270632', '_version_': 1785734388696219683}, 'heart 10wk': {'id': '684_Heart_10wk;_PRJNA270632', 'gene': 684, 'source_name': 'heart 10wk', 'full_rpkm': 3.70275, 'exp_rpkm': 3.7, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388696219684}, 'heart 11wk': {'id': '684_Heart_11wk;_PRJNA270632', 'gene': 684, 'source_name': 'heart 11wk', 'full_rpkm': 0.459843, 'exp_rpkm': 0.46, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388696219685}, 'heart 17wk': {'id': '684_Heart_17wk;_PRJNA270632', 'gene': 684, 'source_name': 'heart 17wk', 'full_rpkm': 0.494173, 'exp_rpkm': 0.494, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388696219686}, 'heart 18wk': {'id': '684_Heart_18wk;_PRJNA270632', 'gene': 684, 'source_name': 'heart 18wk', 'full_rpkm': 0.963221, 'exp_rpkm': 0.963, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388696219687}, 'heart 20wk': {'id': '684_Heart_20wk_PRJNA270632', 'gene': 684, 'source_name': 'heart 20wk', 'full_rpkm': 0.256569, 'exp_rpkm': 0.257, 'var': 0.01266672, 'project_desc': 'PRJNA270632', '_version_': 1785734388696219688}, 'intestine 10wk': {'id': '684_Intestine_10wk_PRJNA270632', 'gene': 684, 'source_name': 'intestine 10wk', 'full_rpkm': 0.334327, 'exp_rpkm': 0.334, 'var': 0.0959428, 'project_desc': 'PRJNA270632', '_version_': 1785734388696219689}, 'intestine 11wk': {'id': '684_Intestine_11wk_PRJNA270632', 'gene': 684, 'source_name': 'intestine 11wk', 'full_rpkm': 0.772423, 'exp_rpkm': 0.772, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388696219690}, 'intestine 15wk': {'id': '684_Intestine_15wk_PRJNA270632', 'gene': 684, 'source_name': 'intestine 15wk', 'full_rpkm': 2.46469, 'exp_rpkm': 2.46, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388697268224}, 'intestine 17wk': {'id': '684_Intestine_17wk_PRJNA270632', 'gene': 684, 'source_name': 'intestine 17wk', 'full_rpkm': 2.27306, 'exp_rpkm': 2.27, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388697268225}, 'intestine 20wk': {'id': '684_Intestine_20wk_PRJNA270632', 'gene': 684, 'source_name': 'intestine 20wk', 'full_rpkm': 1.94722, 'exp_rpkm': 1.95, 'var': 0.218886, 'project_desc': 'PRJNA270632', '_version_': 1785734388697268226}, 'kidney 10wk': {'id': '684_Kidney_10wk_PRJNA270632', 'gene': 684, 'source_name': 'kidney 10wk', 'full_rpkm': 3.07183, 'exp_rpkm': 3.07, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388697268227}, 'kidney 16wk': {'id': '684_Kidney_16wk_PRJNA270632', 'gene': 684, 'source_name': 'kidney 16wk', 'full_rpkm': 0.863424, 'exp_rpkm': 0.863, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388697268228}, 'kidney 20wk': {'id': '684_Kidney_20wk_PRJNA270632', 'gene': 684, 'source_name': 'kidney 20wk', 'full_rpkm': 0.756155, 'exp_rpkm': 0.756, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388697268229}, 'lung 10wk': {'id': '684_Lung_10wk_PRJNA270632', 'gene': 684, 'source_name': 'lung 10wk', 'full_rpkm': 0.271434, 'exp_rpkm': 0.271, 'var': 0.0082071, 'project_desc': 'PRJNA270632', '_version_': 1785734388697268230}, 'lung 17wk': {'id': '684_Lung_17wk_PRJNA270632', 'gene': 684, 'source_name': 'lung 17wk', 'full_rpkm': 1.51939, 'exp_rpkm': 1.52, 'var': 0.0319326, 'project_desc': 'PRJNA270632', '_version_': 1785734388697268231}, 'lung 20wk': {'id': '684_Lung_20wk_PRJNA270632', 'gene': 684, 'source_name': 'lung 20wk', 'full_rpkm': 2.07836, 'exp_rpkm': 2.08, 'var': 0.1721414, 'project_desc': 'PRJNA270632', '_version_': 1785734388697268232}, 'stomach 10wk': {'id': '684_Stomach_10wk_PRJNA270632', 'gene': 684, 'source_name': 'stomach 10wk', 'full_rpkm': 1.76824, 'exp_rpkm': 1.77, 'var': 0.1611836, 'project_desc': 'PRJNA270632', '_version_': 1785734388697268233}, 'stomach 16wk': {'id': '684_Stomach_16wk_PRJNA270632', 'gene': 684, 'source_name': 'stomach 16wk', 'full_rpkm': 1.21592, 'exp_rpkm': 1.22, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388697268234}, 'stomach 18wk': {'id': '684_Stomach_18wk_PRJNA270632', 'gene': 684, 'source_name': 'stomach 18wk', 'full_rpkm': 3.38374, 'exp_rpkm': 3.38, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388697268235}, 'stomach 20wk': {'id': '684_Stomach_20wk_PRJNA270632', 'gene': 684, 'source_name': 'stomach 20wk', 'full_rpkm': 3.68134, 'exp_rpkm': 3.68, 'var': 0.550476, 'project_desc': 'PRJNA270632', '_version_': 1785734388697268236}};
|
||
|
||
|
||
|
||
|
||
window.details_data = {"adrenal 10wk": [{"id": "metadata_9606_SAMN03267754", "gene": 684, "sample_id": "SAMN03267754", "full_rpkm": 2.63249, "exp_rpkm": 2.63, "exp_total": 13018, "project_desc": "PRJNA270632", "_version_": 1785734387345653765, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "adrenal 10wk", "exp_Mcount": 4852.92}], "adrenal 16wk": [{"id": "metadata_9606_SAMN03267755", "gene": 684, "sample_id": "SAMN03267755", "full_rpkm": 10.5393, "exp_rpkm": 10.5, "exp_total": 78069, "project_desc": "PRJNA270632", "_version_": 1785734387345653764, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "adrenal 16wk", "exp_Mcount": 7269.31}], "adrenal 18wk": [{"id": "metadata_9606_SAMN03267761", "gene": 684, "sample_id": "SAMN03267761", "full_rpkm": 23.3842, "exp_rpkm": 23.4, "exp_total": 159065, "project_desc": "PRJNA270632", "_version_": 1785734387345653763, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "adrenal 18wk", "exp_Mcount": 6675.41}], "adrenal 20wk": [{"id": "metadata_9606_SAMN03267762", "gene": 684, "sample_id": "SAMN03267762", "full_rpkm": 25.653, "exp_rpkm": 25.7, "exp_total": 197667, "project_desc": "PRJNA270632", "_version_": 1785734387345653761, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "adrenal 20wk", "exp_Mcount": 7561.75}, {"id": "metadata_9606_SAMN03267753", "gene": 684, "sample_id": "SAMN03267753", "full_rpkm": 21.6676, "exp_rpkm": 21.7, "exp_total": 146783, "project_desc": "PRJNA270632", "_version_": 1785734387345653762, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "adrenal 20wk", "exp_Mcount": 6647.98}], "heart 10wk": [{"id": "metadata_9606_SAMN03267750", "gene": 684, "sample_id": "SAMN03267750", "full_rpkm": 3.70275, "exp_rpkm": 3.7, "exp_total": 20149, "project_desc": "PRJNA270632", "_version_": 1785734387345653760, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 10wk", "exp_Mcount": 5340.16}], "heart 11wk": [{"id": "metadata_9606_SAMN03267763", "gene": 684, "sample_id": "SAMN03267763", "full_rpkm": 0.459843, "exp_rpkm": 0.46, "exp_total": 2782, "project_desc": "PRJNA270632", "_version_": 1785734387344605210, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 11wk", "exp_Mcount": 5937.09}], "heart 17wk": [{"id": "metadata_9606_SAMN03267757", "gene": 684, "sample_id": "SAMN03267757", "full_rpkm": 0.494173, "exp_rpkm": 0.494, "exp_total": 3982, "project_desc": "PRJNA270632", "_version_": 1785734387344605209, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 17wk", "exp_Mcount": 7907.66}], "heart 18wk": [{"id": "metadata_9606_SAMN03267751", "gene": 684, "sample_id": "SAMN03267751", "full_rpkm": 0.963221, "exp_rpkm": 0.963, "exp_total": 6263, "project_desc": "PRJNA270632", "_version_": 1785734387344605208, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 18wk", "exp_Mcount": 6380.91}], "heart 20wk": [{"id": "metadata_9606_SAMN03267756", "gene": 684, "sample_id": "SAMN03267756", "full_rpkm": 0.188562, "exp_rpkm": 0.189, "exp_total": 2086, "project_desc": "PRJNA270632", "_version_": 1785734387344605205, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 20wk", "exp_Mcount": 10856.4}, {"id": "metadata_9606_SAMN03267764", "gene": 684, "sample_id": "SAMN03267764", "full_rpkm": 0.165947, "exp_rpkm": 0.166, "exp_total": 862, "project_desc": "PRJNA270632", "_version_": 1785734387344605206, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 20wk", "exp_Mcount": 5097.56}, {"id": "metadata_9606_SAMN03267760", "gene": 684, "sample_id": "SAMN03267760", "full_rpkm": 0.415197, "exp_rpkm": 0.415, "exp_total": 2536, "project_desc": "PRJNA270632", "_version_": 1785734387344605207, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 20wk", "exp_Mcount": 5994.06}], "intestine 10wk": [{"id": "metadata_9606_SAMN03267752", "gene": 684, "sample_id": "SAMN03267752", "full_rpkm": 0.644073, "exp_rpkm": 0.644, "exp_total": 5125, "project_desc": "PRJNA270632", "_version_": 1785734387344605203, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 10wk", "exp_Mcount": 7808.8}, {"id": "metadata_9606_SAMN03267759", "gene": 684, "sample_id": "SAMN03267759", "full_rpkm": 0.0245806, "exp_rpkm": 0.0246, "exp_total": 173, "project_desc": "PRJNA270632", "_version_": 1785734387344605204, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 10wk", "exp_Mcount": 6906.84}], "intestine 11wk": [{"id": "metadata_9606_SAMN03267758", "gene": 684, "sample_id": "SAMN03267758", "full_rpkm": 0.772423, "exp_rpkm": 0.772, "exp_total": 3412, "project_desc": "PRJNA270632", "_version_": 1785734387344605202, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 11wk", "exp_Mcount": 4334.9}], "intestine 15wk": [{"id": "metadata_9606_SAMN03267775", "gene": 684, "sample_id": "SAMN03267775", "full_rpkm": 2.46469, "exp_rpkm": 2.46, "exp_total": 9997, "project_desc": "PRJNA270632", "_version_": 1785734387344605201, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 15wk", "exp_Mcount": 3980.45}], "intestine 17wk": [{"id": "metadata_9606_SAMN03267782", "gene": 684, "sample_id": "SAMN03267782", "full_rpkm": 2.27306, "exp_rpkm": 2.27, "exp_total": 22388, "project_desc": "PRJNA270632", "_version_": 1785734387344605200, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 17wk", "exp_Mcount": 9665.65}], "intestine 20wk": [{"id": "metadata_9606_SAMN03267766", "gene": 684, "sample_id": "SAMN03267766", "full_rpkm": 1.47937, "exp_rpkm": 1.48, "exp_total": 6273, "project_desc": "PRJNA270632", "_version_": 1785734387344605198, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 20wk", "exp_Mcount": 4161.26}, {"id": "metadata_9606_SAMN03267769", "gene": 684, "sample_id": "SAMN03267769", "full_rpkm": 2.41508, "exp_rpkm": 2.42, "exp_total": 9583, "project_desc": "PRJNA270632", "_version_": 1785734387344605199, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 20wk", "exp_Mcount": 3894.01}], "kidney 10wk": [{"id": "metadata_9606_SAMN03267784", "gene": 684, "sample_id": "SAMN03267784", "full_rpkm": 3.07183, "exp_rpkm": 3.07, "exp_total": 14792, "project_desc": "PRJNA270632", "_version_": 1785734387344605197, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "kidney 10wk", "exp_Mcount": 4725.59}], "kidney 16wk": [{"id": "metadata_9606_SAMN03267772", "gene": 684, "sample_id": "SAMN03267772", "full_rpkm": 0.863424, "exp_rpkm": 0.863, "exp_total": 13451, "project_desc": "PRJNA270632", "_version_": 1785734387344605196, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "kidney 16wk", "exp_Mcount": 15288.2}], "kidney 20wk": [{"id": "metadata_9606_SAMN03267777", "gene": 684, "sample_id": "SAMN03267777", "full_rpkm": 0.756155, "exp_rpkm": 0.756, "exp_total": 7921, "project_desc": "PRJNA270632", "_version_": 1785734387344605195, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "kidney 20wk", "exp_Mcount": 10280.0}], "lung 10wk": [{"id": "metadata_9606_SAMN03267770", "gene": 684, "sample_id": "SAMN03267770", "full_rpkm": 0.362027, "exp_rpkm": 0.362, "exp_total": 2196, "project_desc": "PRJNA270632", "_version_": 1785734387344605193, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 10wk", "exp_Mcount": 5952.75}, {"id": "metadata_9606_SAMN03267767", "gene": 684, "sample_id": "SAMN03267767", "full_rpkm": 0.180841, "exp_rpkm": 0.181, "exp_total": 964, "project_desc": "PRJNA270632", "_version_": 1785734387344605194, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 10wk", "exp_Mcount": 5231.26}], "lung 17wk": [{"id": "metadata_9606_SAMN03267778", "gene": 684, "sample_id": "SAMN03267778", "full_rpkm": 1.69808, "exp_rpkm": 1.7, "exp_total": 10822, "project_desc": "PRJNA270632", "_version_": 1785734387344605191, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 17wk", "exp_Mcount": 6254.23}, {"id": "metadata_9606_SAMN03267776", "gene": 684, "sample_id": "SAMN03267776", "full_rpkm": 1.34069, "exp_rpkm": 1.34, "exp_total": 5114, "project_desc": "PRJNA270632", "_version_": 1785734387344605192, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 17wk", "exp_Mcount": 3743.33}], "lung 20wk": [{"id": "metadata_9606_SAMN03267780", "gene": 684, "sample_id": "SAMN03267780", "full_rpkm": 2.49326, "exp_rpkm": 2.49, "exp_total": 23552, "project_desc": "PRJNA270632", "_version_": 1785734387344605189, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 20wk", "exp_Mcount": 9270.13}, {"id": "metadata_9606_SAMN03267768", "gene": 684, "sample_id": "SAMN03267768", "full_rpkm": 1.66346, "exp_rpkm": 1.66, "exp_total": 10768, "project_desc": "PRJNA270632", "_version_": 1785734387344605190, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 20wk", "exp_Mcount": 6352.54}], "stomach 10wk": [{"id": "metadata_9606_SAMN03267773", "gene": 684, "sample_id": "SAMN03267773", "full_rpkm": 1.36677, "exp_rpkm": 1.37, "exp_total": 9167, "project_desc": "PRJNA270632", "_version_": 1785734387344605187, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 10wk", "exp_Mcount": 6582.02}, {"id": "metadata_9606_SAMN03267779", "gene": 684, "sample_id": "SAMN03267779", "full_rpkm": 2.16972, "exp_rpkm": 2.17, "exp_total": 15994, "project_desc": "PRJNA270632", "_version_": 1785734387344605188, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 10wk", "exp_Mcount": 7234.02}], "stomach 16wk": [{"id": "metadata_9606_SAMN03267774", "gene": 684, "sample_id": "SAMN03267774", "full_rpkm": 1.21592, "exp_rpkm": 1.22, "exp_total": 7706, "project_desc": "PRJNA270632", "_version_": 1785734387344605186, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 16wk", "exp_Mcount": 6219.43}], "stomach 18wk": [{"id": "metadata_9606_SAMN03267771", "gene": 684, "sample_id": "SAMN03267771", "full_rpkm": 3.38374, "exp_rpkm": 3.38, "exp_total": 20069, "project_desc": "PRJNA270632", "_version_": 1785734387344605185, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 18wk", "exp_Mcount": 5820.42}], "stomach 20wk": [{"id": "metadata_9606_SAMN03267765", "gene": 684, "sample_id": "SAMN03267765", "full_rpkm": 4.19063, "exp_rpkm": 4.19, "exp_total": 19193, "project_desc": "PRJNA270632", "_version_": 1785734387342508032, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 20wk", "exp_Mcount": 4494.58}, {"id": "metadata_9606_SAMN03267781", "gene": 684, "sample_id": "SAMN03267781", "full_rpkm": 4.22115, "exp_rpkm": 4.22, "exp_total": 19641, "project_desc": "PRJNA270632", "_version_": 1785734387343556608, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 20wk", "exp_Mcount": 4566.24}, {"id": "metadata_9606_SAMN03267783", "gene": 684, "sample_id": "SAMN03267783", "full_rpkm": 2.63222, "exp_rpkm": 2.63, "exp_total": 12887, "project_desc": "PRJNA270632", "_version_": 1785734387344605184, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 20wk", "exp_Mcount": 4804.58}]}
|
||
window.taxId = 9606
|
||
</script>
|
||
|
||
|
||
<div>
|
||
|
||
|
||
|
||
<select name="p" id="project-selector">
|
||
|
||
|
||
<option value="SRP051249" selected="selected" data-bioproject="PRJNA270632">
|
||
|
||
Tissue-specific circular RNA induction during human fetal development
|
||
|
||
</option>
|
||
|
||
|
||
|
||
<option value="SRP056969" data-bioproject="PRJNA280600">
|
||
|
||
RNA sequencing of total RNA from 20 human tissues
|
||
|
||
|
||
</option>
|
||
|
||
|
||
|
||
<option value="ERP003613" data-bioproject="PRJEB4337">
|
||
|
||
HPA RNA-seq normal tissues
|
||
|
||
|
||
</option>
|
||
|
||
|
||
|
||
</select>
|
||
|
||
|
||
|
||
<ul id="project-summary">
|
||
<li id="project-summary-title">Project title:
|
||
|
||
Tissue-specific circular RNA induction during human fetal development
|
||
|
||
</li>
|
||
|
||
|
||
<li id="project-summary-desc">Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA</li>
|
||
|
||
|
||
|
||
<li id="project-summary-bioprojects">BioProject: <a href="/bioproject/PRJNA270632/">PRJNA270632</a>
|
||
</li>
|
||
|
||
<li id="project-summary-pubs">Publication:
|
||
|
||
|
||
<span><a href="/pubmed/26076956/">PMID 26076956</a></span>
|
||
|
||
</li>
|
||
|
||
|
||
<li id="project-summary-analysis-date">Analysis date: Mon Apr 2 22:54:59 2018</li>
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
<div id="gene-expr-details" class="expression-chart"></div>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<script type="text/javascript" src="https://www.gstatic.com/charts/loader.js"></script>
|
||
<script type="text/javascript">
|
||
google.charts.load('current', {
|
||
'packages':[ 'corechart']
|
||
});
|
||
|
||
</script>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-bibliography">
|
||
<section class="rprt-section-header" id="bibliography"><h2 id="header-bibliography"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-bibliography .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Bibliography</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Bibliography" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
|
||
<div class="rprt-section-body" style="">
|
||
<div class="generif-pubmed">
|
||
<h3 id="relatedarticlesinpubmed">
|
||
<a href="#" class="jig-ncbitoggler-open">Related articles in PubMed</a>
|
||
</h3>
|
||
<div class="generefbl-link">
|
||
<ol class="generef-link">
|
||
<li>
|
||
<a href="/pubmed/23047007/" ref="ordinalpos=1&ncbi_uid=684&link_uid=23047007">The role of the structural domains of human BST-2 in inhibiting the release of xenotropic murine leukemia virus-related virus.</a>
|
||
<span class="pubmed-auth-date"> Hu S, <em>et al</em>. Biochem Biophys Res Commun, 2012 Nov 9. PMID 23047007</span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/28331088/" ref="ordinalpos=2&ncbi_uid=684&link_uid=28331088">BST-2 Expression Modulates Small CD4-Mimetic Sensitization of HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity.</a>
|
||
<span class="pubmed-auth-date"> Richard J, <em>et al</em>. J Virol, 2017 Jun 1. PMID 28331088, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC5432882/" ref="ordinalpos=0&ncbi_uid=684&link_uid=PMC5432882">Free PMC Article</a></span></span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/21222046/" ref="ordinalpos=3&ncbi_uid=684&link_uid=21222046">Tetherin and its viral antagonists.</a>
|
||
<span class="pubmed-auth-date"> Kuhl BD, <em>et al</em>. J Neuroimmune Pharmacol, 2011 Jun. PMID 21222046, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC3087111/" ref="ordinalpos=0&ncbi_uid=684&link_uid=PMC3087111">Free PMC Article</a></span></span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/25462350/" ref="ordinalpos=4&ncbi_uid=684&link_uid=25462350">Tetherin restricts HSV-2 release and is counteracted by multiple viral glycoproteins.</a>
|
||
<span class="pubmed-auth-date"> Liu Y, <em>et al</em>. Virology, 2015 Jan 15. PMID 25462350</span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/28466381/" ref="ordinalpos=5&ncbi_uid=684&link_uid=28466381">Tetherin antagonism by V proteins is a common trait among the genus Rubulavirus.</a>
|
||
<span class="pubmed-auth-date"> Ohta K, <em>et al</em>. Med Microbiol Immunol, 2017 Aug. PMID 28466381</span>
|
||
</li>
|
||
</ol>
|
||
<p class="see-all-pm">
|
||
<a href="/pubmed?LinkName=gene_pubmed&from_uid=684" title="See all 411 citations in Pubmed">See all (411) citations in PubMed</a>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="generif-pubmed generif">
|
||
<h3 id="generifsgenereferencesintofunctions">
|
||
<a href="#" class="jig-ncbitoggler-open">GeneRIFs: Gene References Into Functions</a>
|
||
</h3>
|
||
<div>
|
||
<a href="/gene/about-generif" class="whatisthis">What's a GeneRIF?</a>
|
||
<div class="generefbl-link">
|
||
<ol class="generef-link">
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/38360199" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=684&link_uid=38360199">Neuronal BST2: A Pruritic Mediator alongside Protease-Activated Receptor 2 in the IL-27-Driven Itch Pathway.</a>
|
||
<div id="gene-popper1" class="gene-rif-popper">Title: Neuronal BST2: A Pruritic Mediator alongside Protease-Activated Receptor 2 in the IL-27-Driven Itch Pathway.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/38747016" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=684&link_uid=38747016">Autophagy-related protein 5 (ATG5) interacts with bone marrow stromal cell antigen 2 (BST2) to stimulate HBV replication through antagonizing the antiviral activity of BST2.</a>
|
||
<div id="gene-popper2" class="gene-rif-popper">Title: Autophagy-related protein 5 (ATG5) interacts with bone marrow stromal cell antigen 2 (BST2) to stimulate HBV replication through antagonizing the antiviral activity of BST2.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/38197534" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=684&link_uid=38197534">BST2 promotes gastric cancer metastasis under the regulation of HOXD9 and PABPC1.</a>
|
||
<div id="gene-popper3" class="gene-rif-popper">Title: BST2 promotes gastric cancer metastasis under the regulation of HOXD9 and PABPC1.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/38140605" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=684&link_uid=38140605">Tetherin Restricts SARS-CoV-2 despite the Presence of Multiple Viral Antagonists.</a>
|
||
<div id="gene-popper4" class="gene-rif-popper">Title: Tetherin Restricts SARS-CoV-2 despite the Presence of Multiple Viral Antagonists.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/37818801" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=684&link_uid=37818801">Tetherin antagonism by SARS-CoV-2 ORF3a and spike protein enhances virus release.</a>
|
||
<div id="gene-popper5" class="gene-rif-popper">Title: Tetherin antagonism by SARS-CoV-2 ORF3a and spike protein enhances virus release.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/37922253" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=684&link_uid=37922253">Human BST2 inhibits rabies virus release independently of cysteine-linked dimerization and asparagine-linked glycosylation.</a>
|
||
<div id="gene-popper6" class="gene-rif-popper">Title: Human BST2 inhibits rabies virus release independently of cysteine-linked dimerization and asparagine-linked glycosylation.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/37211321" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=684&link_uid=37211321">Understanding how transmembrane domains regulate interactions between human BST-2 and the SARS-CoV-2 accessory protein ORF7a.</a>
|
||
<div id="gene-popper7" class="gene-rif-popper">Title: Understanding how transmembrane domains regulate interactions between human BST-2 and the SARS-CoV-2 accessory protein ORF7a.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/37210387" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=684&link_uid=37210387">CD317 maintains proteostasis and cell survival in response to proteasome inhibitors by targeting calnexin for RACK1-mediated autophagic degradation.</a>
|
||
<div id="gene-popper8" class="gene-rif-popper">Title: CD317 maintains proteostasis and cell survival in response to proteasome inhibitors by targeting calnexin for RACK1-mediated autophagic degradation.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/37155854" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=684&link_uid=37155854">ATG5 selectively engages virus-tethered BST2/tetherin in an LC3C-associated pathway.</a>
|
||
<div id="gene-popper9" class="gene-rif-popper">Title: ATG5 selectively engages virus-tethered BST2/tetherin in an LC3C-associated pathway.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/36929425" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=684&link_uid=36929425">BST2 regulated by the transcription factor STAT1 can promote metastasis, invasion and proliferation of oral squamous cell carcinoma via the AKT/ERK1/2 signaling pathway.</a>
|
||
<div id="gene-popper10" class="gene-rif-popper">Title: BST2 regulated by the transcription factor STAT1 can promote metastasis, invasion and proliferation of oral squamous cell carcinoma via the AKT/ERK1/2 signaling pathway.</div>
|
||
</li>
|
||
</ol>
|
||
</div>
|
||
<div class="submit-genrif">
|
||
<span>Submit:</span>
|
||
<a href="/gene/submit-generif/?geneId=684&sym=BST2&name=bone marrow stromal cell antigen 2&org=Homo sapiens">New GeneRIF</a>
|
||
<a href="/RefSeq/update.cgi?geneid=684&symbol=BST2;task=fixpub">Correction</a>
|
||
<a href="https://www.ncbi.nlm.nih.gov/gene?db=gene&report=generif&term=684" class="seeall-generif">See all GeneRIFs (244)</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-phenotypes">
|
||
<section class="rprt-section-header" id="phenotypes">
|
||
<h2 id="header-phenotypes">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-phenotypes .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Phenotypes</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Phenotype" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body info-phenotype">
|
||
<p class="nochild-link">
|
||
<a href="/gtr/tests/?term=BST2[gene]">Find tests for this gene in the NIH Genetic Testing Registry (GTR)</a>
|
||
</p>
|
||
<p class="nochild-link">
|
||
<a href="/gap/PheGenI?tab=1&gene=684">Review eQTL and phenotype association data in this region using PheGenI</a>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-variation">
|
||
<section class="rprt-section-header" id="variation">
|
||
<h2 id="header-variation">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-variation .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Variation</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.variation" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<p class="nochild-link">
|
||
<a href="/clinvar/?term=BST2[gene]" ref="log$=recordlinks">See variants in ClinVar</a>
|
||
</p>
|
||
<p class="nochild-link">
|
||
<a href="/dbvar?LinkName=gene_dbvar&from_uid=684" ref="log$=recordlinks">See studies and variants in dbVar</a>
|
||
</p>
|
||
<p class="nochild-link">
|
||
<a href="/variation/view/?q=684[geneid]&assm=GCF_000001405.25" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh37.p13)">See Variation Viewer (GRCh37.p13)</a>
|
||
</p>
|
||
<p class="nochild-link">
|
||
<a href="/variation/view/?q=684[geneid]" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh38)">See Variation Viewer (GRCh38)</a>
|
||
</p>
|
||
<set></set>
|
||
<set></set>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-HIV-1-interactions">
|
||
<section class="rprt-section-header" id="HIV-1-interactions">
|
||
<h2 id="header-HIV-1-interactions">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-HIV-1-interactions .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">HIV-1 interactions</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.HIV1_interactions" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div class="fgrid">
|
||
<h3 id="replicationinteractions">Replication interactions</h3>
|
||
<table summary="replication interactions" class="jig-ncbigrid">
|
||
<thead>
|
||
<tr>
|
||
<th id="hivinter">Interaction</th>
|
||
<th id="hivpub">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="hivinter">Capsid expressing (p24+) cells from pleural fluid of HIV-1/TB coinfected patients or in vitro infected PBMC (whit HIV-1 NL4-3 or NLAD8) downregulate HLA-A/B/C and BST2 (Tetherin) concomitantly with CD4 downregulation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26497177" href="/pubmed/26497177">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivinter">HIV-1 infectivity/virus release from cells correlates negatively with cell surface BST2 expression levels</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26184634" href="/pubmed/26184634">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivinter">HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of BST2</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26497177,26439863" href="/pubmed/26497177,26439863">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivinter">Knockdown of BST-2 by siRNA enhances production of infectious HIV-1 particles in HeLa cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23613843" href="/pubmed/23613843">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
<h3 id="proteininteractions">Protein interactions</h3>
|
||
<table summary="protein interactions" class="jig-ncbigrid">
|
||
<thead>
|
||
<tr>
|
||
<th id="hivprotein">Protein</th>
|
||
<th id="gene-hivprotein">Gene</th>
|
||
<th id="hivinter">Interaction</th>
|
||
<th id="hivpub">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/9629363">Envelope surface glycoprotein gp160, precursor</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu disrupts the co-localization between HIV-1 Env and tetherin in HeLa P4-R5 cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25759385" href="/pubmed/25759385">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">BST-2 co-localizes with HIV-1 Env at the virological synapse on infected T cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22194693,20861257" href="/pubmed/22194693,20861257">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/28872818">Nef</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 group M Nef downregulates tetherin from the cell surface and is dependent upon amino acids at positions 4, 5, 28, 33, 40, 90, 103, and 109 in Nef</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 27654287" href="/pubmed/27654287">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 (SF2) Nef downregulates BST2 (CD317/Tetherin); downregulation is dependent upon a proline-rich SH3 binding domain in Nef</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26656785" href="/pubmed/26656785">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 C1 Nef binds to residues in the N-terminus of human BST-2 (tetherin) and allows for HIV-1 release</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 27654287" href="/pubmed/27654287">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 group M and O Nefs downregulate the longer isoform of human tetherin but not the shorter isoform</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 27654287,25525794,25468793" href="/pubmed/27654287,25525794,25468793">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">Mutation of the four residues (K186V, Q188R, S192A, and L195T) in HIV-1 group O Nefs significantly reduces Nef-mediated downregulation of human tetherin</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25525794,25468793" href="/pubmed/25525794,25468793">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 group O Nefs evolve the ability to downregulate surface levels of tetherin and sequester it to intracellular perinuclear compartments</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25525794,25468793" href="/pubmed/25525794,25468793">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">Residues I163 and C169 of HIV-1 Nef from chimpanzee-adapted HIV-1 JC16 are specifically involved in its interaction with tetherin</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22980333" href="/pubmed/22980333">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">Tetherin upregulation in HIV-1-infected macrophages is HIV-1 Nef dependent, not a direct consequence of type I interferon induction</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22980332" href="/pubmed/22980332">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 replication in immature dendritic cells upregulates tetherin independently of Vpu, but in a Nef-dependent manner</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21504576" href="/pubmed/21504576">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/9629360">Pr55(Gag)</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu disrupts the co-localization between HIV-1 Gag and tetherin in a Trp-76-dependent manner in HeLa P4-R5 cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25759385" href="/pubmed/25759385">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">In cells expressing either wild-type or vpu(-) virus, BST-2 and HIV-1 Gag co-localize both along the plasma membrane and in endosomes</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25759385,24991932,23311681,22980332,22398279,22291694,19036818,18342597" href="/pubmed/25759385,24991932,23311681,22980332,22398279,22291694,19036818,18342597">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">BST-2 delays processing of cellular membrane-associated Gag proteins and adversely affects formation of the core structure in HIV-1 particles</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24991932,20861258" href="/pubmed/24991932,20861258">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">The interaction between HIV-1 Gag and TSG101 enhances tetherin recruitment in HeLa cells. Both TSG101 and ALIX binding sites within the p6 domain of Gag enhance tetherin recruitment to Gag assembly sites in T cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23408603" href="/pubmed/23408603">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">Tetherin potently inhibits release of Fyn(10)fullMA-Gag, which contains the first 10 amino acids of Fyn kinase at the N terminus of Gag, under cholesterol-depleting conditions in HeLa and HT-1080 cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23408603" href="/pubmed/23408603">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">Tetherin co-localizes with HIV-1 Gag in CD81- and CD63-enriched intracellular virus-containing compartments in macrophages, and that a separate population of tetherin is located in the TGN</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22980332" href="/pubmed/22980332">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">Tetherin accumulates with Gag at the contact zone between infected and target cells, but does not prevent the formation of virological synapses</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23311681,22980332,20861257,20585562" href="/pubmed/23311681,22980332,20861257,20585562">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">Cell-free virus particles produced from BST-2 and HIV-1(Vpu-) cotransfected 293T cells have a significant accumulation of the pr55Gag precursor and the p40Gag intermediate products, leading to diminish the infectivity of HIV-1 particles</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20861258" href="/pubmed/20861258">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/9629358">Tat</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 and the viral protein Tat modulate the expression of bone marrow stromal cell antigen 2 (BST2) in immature dendritic cells and monocyte-derived macrophages</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24742347" href="/pubmed/24742347">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/28872817">Vpr</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155807">vpr</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpr downregulates BST2 expression in human glial cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21918813,21645334" href="/pubmed/21918813,21645334">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/9629366">Vpu</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu (membrane proximal basic residues required) increases the levels of a 23-kDa form of unglycosylated tetherin (transmembrane domain required) in the presence of overexpressed SGTA whereby the C-terminus of SGTA is required for this to occur</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 27103333" href="/pubmed/27103333">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 (NL4-3) Vpu downregulates BST2 (CD317/Tetherin); downregulation is dependent on the presence of serines at positions 52 and 56 in Vpu</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26656785" href="/pubmed/26656785">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 subtypes A, B, C, D, and G Vpus inhibit tetherin and allow for HIV-1 release</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 27654287" href="/pubmed/27654287">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu antagonizes the effects of BCA2 on HIV-1 particle production in ""tetherin-positive"" cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20019814" href="/pubmed/20019814">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">The betaTrCP binding motif DSGxxS of Vpu is required for optimal downregulation of BST-2 and enhancement of virion-release. Vpu serine (S52/S56) mutants are severely impaired for their ability to counteract tetherin antiviral activity</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26656785,25759385,24574397,23514615,22811908,22524180,22524179,22524176,21994744,21994665,21902775,21741003,21674066,21610122,21310048,21237475,21176220,20485522,20434978,20386718,20201792,20078884,20012522,19837671,19730691,19478868" href="/pubmed/26656785,25759385,24574397,23514615,22811908,22524180,22524179,22524176,21994744,21994665,21902775,21741003,21674066,21610122,21310048,21237475,21176220,20485522,20434978,20386718,20201792,20078884,20012522,19837671,19730691,19478868">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpus from transmission/founder virus clones downregulates BST2 (Tetherin) but do not efficiently downregulate CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26184634" href="/pubmed/26184634">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu downregulates cell (CEMT4, Primary CD4+ T cells) surface expression of BST2 (tetherin)</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26439863,26215564" href="/pubmed/26439863,26215564">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Vpu counteracts BST2 (tetherin) antiviral activity in HIV-1 transduced cells (293T vs 293T stably expressing BST2(tetherin))</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26317613" href="/pubmed/26317613">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Vpu from most transmission/founder HIV-1 downregulates BST2 and significantly correlates with level of virus release but did not efficiently downregulate CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26184634" href="/pubmed/26184634">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Vpu-mediated suppresion of IFN-1 production requires engagement and activation of the LILRA4 (ILT7) plasmacytoid dendritic cell receptor by BST2</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26172439" href="/pubmed/26172439">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Vpu relocalizes/redistributes BST2 outside assembly sites in primary CD4+ T cells and in SupT1 cells expressing the short BST2 isoform</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26172439" href="/pubmed/26172439">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Vpu-mediated modulation of IFN-1 production by plasmacytoid dendritic cells requires the presence of BST2 on infected donor cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26172439" href="/pubmed/26172439">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu antagonizes BST2 restiction of HIV-1 replication as demonstrated via mathematical modeling</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26385832" href="/pubmed/26385832">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 (NL4-3) Vpu downregulates BST2 via a cullin-RING E3 ubiquitin ligase complex-independent mechanism</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26215564" href="/pubmed/26215564">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu downregulates BST-2. The transmembrane/ion channel domain and conserved serines in the cytoplasmic domain of Vpu are required for the Vpu-mediated downregulation of BST-2</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26439863,25827531,25807049,25759385,25620704,24991932,24910430,24843023,24822052,24733916,24623433,24623426,24574397,24551192,24465210,24257748,24246762,24195843,24158820,24067975,24035804,23916489,23831603,23633949,23582304,23367562,23311681,23308067,23284757,23043100,22811908,22647704,22553496,22524178,22524177,22509177,22383521,22357275,22222210,22180752,22072710,21994772,21994744,21994665,21955466,21922073,21902775,21900423,21775449,21757214,21741003,21687426,21674066,21607084,21601230,21304933,21191020,21184674,21176220,20926557,20858517,20688520,20571604,20485522,20434978,20386718,20201792,20012522,19929170,19837671,19694548,19474106,19305418,19286137,19286130,19214216,19196977,19149995,19149577,18342597" href="/pubmed/26439863,25827531,25807049,25759385,25620704,24991932,24910430,24843023,24822052,24733916,24623433,24623426,24574397,24551192,24465210,24257748,24246762,24195843,24158820,24067975,24035804,23916489,23831603,23633949,23582304,23367562,23311681,23308067,23284757,23043100,22811908,22647704,22553496,22524178,22524177,22509177,22383521,22357275,22222210,22180752,22072710,21994772,21994744,21994665,21955466,21922073,21902775,21900423,21775449,21757214,21741003,21687426,21674066,21607084,21601230,21304933,21191020,21184674,21176220,20926557,20858517,20688520,20571604,20485522,20434978,20386718,20201792,20012522,19929170,19837671,19694548,19474106,19305418,19286137,19286130,19214216,19196977,19149995,19149577,18342597">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu counteracts the tetherin-induced retention of HIV-1(delVpu) virion particles. Vpu colocalizes with tetherin in co-expression cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25347789,25210194,24948736,24822052,24782851,24772904,24721789,24676648,24574397,24390322,24246762,24158820,24086611,24067975,23966385,23937976,23825473,23633949,23582304,23528733,23514615,23428096,23260108,23201263,23047923,23043100,23028328,22980332,22952667,22811908,22553496,22533470,22530020,22524181,22524180,22524179,22524178,22524177,22524176,22524175,22509177,22479182,22421880,22405001,22357275,22291694,22286874,22194693,22180752,22103835,22072966,22072710,21994744,21994665,21955466,21900423,21874899,21813615,21775465,21757214,21741003,21687426,21674066,21621240,21607084,21601230,21490095,21304933,21238946,21238941,21209114,21176220,20926557,20920359,20861258,20861257,20850859,20798829,20688520,20686043,20585562,20529266,20485522,20444900,20444895,20434978,20419159,20386718,20329562,20201792,20179761,20167081,20147395,20078884,20019814,20012522,19929170,19917496,19879838,19879831,19864625,19837671,19740980,19737401,19730691,19501037,19474106,19305418,19286137,19286130,19214216,19196977,19149995,19149577,18789977,18541215,18468560,18342597,18200012,18200009" href="/pubmed/25347789,25210194,24948736,24822052,24782851,24772904,24721789,24676648,24574397,24390322,24246762,24158820,24086611,24067975,23966385,23937976,23825473,23633949,23582304,23528733,23514615,23428096,23260108,23201263,23047923,23043100,23028328,22980332,22952667,22811908,22553496,22533470,22530020,22524181,22524180,22524179,22524178,22524177,22524176,22524175,22509177,22479182,22421880,22405001,22357275,22291694,22286874,22194693,22180752,22103835,22072966,22072710,21994744,21994665,21955466,21900423,21874899,21813615,21775465,21757214,21741003,21687426,21674066,21621240,21607084,21601230,21490095,21304933,21238946,21238941,21209114,21176220,20926557,20920359,20861258,20861257,20850859,20798829,20688520,20686043,20585562,20529266,20485522,20444900,20444895,20434978,20419159,20386718,20329562,20201792,20179761,20167081,20147395,20078884,20019814,20012522,19929170,19917496,19879838,19879831,19864625,19837671,19740980,19737401,19730691,19501037,19474106,19305418,19286137,19286130,19214216,19196977,19149995,19149577,18789977,18541215,18468560,18342597,18200012,18200009">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu disrupts the co-localization between HIV-1 Gag and tetherin in a Trp-76-dependent manner in HeLa P4-R5 cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25759385" href="/pubmed/25759385">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu interacts with BST-2 in the trans-Golgi network or in early endosomes, leading to lysosomal degradation of BST-2. Vpu-mediated downregulation of BST-2 depends on cellular ubiquitination machinery via betaTrCP</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25807049,24822052,24782851,23831603,23043100,22811908,22553496,22524180,22524179,22524177,22524176,22509177,22479182,22180752,21994772,21994744,21994665,21922073,21902775,21900423,21813615,21775465,21741003,21176220,20980512,20858517,20798829,20571604,20485522,20434978,20386718,20201792,20012522,19837671,19515779,19478868,19244337" href="/pubmed/25807049,24822052,24782851,23831603,23043100,22811908,22553496,22524180,22524179,22524177,22524176,22509177,22479182,22180752,21994772,21994744,21994665,21922073,21902775,21900423,21813615,21775465,21741003,21176220,20980512,20858517,20798829,20571604,20485522,20434978,20386718,20201792,20012522,19837671,19515779,19478868,19244337">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu mutations (A19E, E29K, II43,46SL, R49G/T, SN53,55RH, S53N, E58K) derived from HIV-1 infected patients have defects for both CD4 and tetherin downregulation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25759385,24465210" href="/pubmed/25759385,24465210">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu stabilizes human tetherin in African green monkey kidney COS cells and still counteracts the ability of tetherin to suppress virus release</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25360760" href="/pubmed/25360760">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Expression of HIV-1 Vpu induces co-localization of tetherin with early endosome protein EEA-1 or late endosome protein LAMP-1</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25360760,24086611" href="/pubmed/25360760,24086611">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">The ability of HIV-1 Vpu to antagonize tetherin is important for the antibody opsonization of HIV-infected cells, which in turn increases FCGRIII (CD16) signaling</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25396265,24623433" href="/pubmed/25396265,24623433">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">RNAi-knockdown of tetherin, but not CD4 or NTB-A, increases the resistance of HIV-infected cells to antibody-dependent cell-mediated cytotoxicity (ADCC), suggesting Vpu protects infected cells from ADCC as a function of its ability to counteract tetherin</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25396265,24733916,24623433,24498878" href="/pubmed/25396265,24733916,24623433,24498878">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">N-terminally deleted BST-2 inhibits HIV-1 Vpu-defective and wild-type HIV-1 particle release, and the BST-2 mutant impairs its activity to activate NF-kappaB activation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25347789" href="/pubmed/25347789">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">The 59EXXXLV64 motif in HIV-1 Vpu is required for Vpu-mediated tetherin downregulation. Vpu E/L/V mutant fails to downregulate tetherin but still interact with beta-TrCP2 and HRS (ESCRT-0)</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24843023,22811908,22524180,22479182" href="/pubmed/24843023,22811908,22524180,22479182">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Vpu requires a functional polyubiquitin/proteasome system for efficient tetherin degradation. K48R ubiquitin mutant partially blocks Vpu-mediated tetherin downregulation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24822052,23831603,22524180,22524179,22180752,20485522,20434978,20419159,19730691" href="/pubmed/24822052,23831603,22524180,22524179,22180752,20485522,20434978,20419159,19730691">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu proteins from nonpandemic HIV-1 O and P strains are poor mediators of human tetherin downregulation. Vpus from nonpandemic HIV-1 N strains are as good tetherin antagonists as those from pandemic HIV-1 M strains</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24822052,22855686,22811908,22524175,22509177,22180752,22171785,21994744,21955466,21900423,21775465,21176220,20926557,20638642,20434978,20201792,20012522,19917496,19917491" href="/pubmed/24822052,22855686,22811908,22524175,22509177,22180752,22171785,21994744,21955466,21900423,21775465,21176220,20926557,20638642,20434978,20201792,20012522,19917496,19917491">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu transmembrane mutants A14N and A18N do not support virus release in the presence of CD317, suggesting that Ala residues at position 14 and 18 are required to antagonize CD317</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24822052,23582304,22524177,22180752,21994744,21775465,21601230" href="/pubmed/24822052,23582304,22524177,22180752,21994744,21775465,21601230">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Vpu interferes with tetherin trafficking to the cell-surface and causes a relocalization of the cellular tetherin with a TGN marker TGN46 in the TGN, suggesting Vpu-mediated antagonism of tetherin involves binding and sequestration of tetherin in the TGN</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24822052,22524180,22479182,22398279,21994744,21994665,21610122,21191020,20485522,20434978,20386718" href="/pubmed/24822052,22524180,22479182,22398279,21994744,21994665,21610122,21191020,20485522,20434978,20386718">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">The plasma membrane clathrin adaptor protein complex AP-2 (mu2) is required for optimal downregulation of cell surface BST-2 by Vpu</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24782851,22524177,20485522,20201792,20012522,19478868" href="/pubmed/24782851,22524177,20485522,20201792,20012522,19478868">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">All three major structural domains (amino-terminal cytoplasmic tail, transmembrane domain, and extracellular coiled-coil domain) of BST-2 are involved in Vpu-mediated antagonism of tetherin</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24822052,24109238,24035804,23831603,23284757,23201263,23043100,22811908,22553496,22524178,22524177,22524176,22524175,22479182,22264038,22180752,21994744,21994665,21176220,21068238,20485522,20444895,20434978,20201792,20147723,20012522,19474106,19461879,19305418,19286130,19149995" href="/pubmed/24822052,24109238,24035804,23831603,23284757,23201263,23043100,22811908,22553496,22524178,22524177,22524176,22524175,22479182,22264038,22180752,21994744,21994665,21176220,21068238,20485522,20444895,20434978,20201792,20147723,20012522,19474106,19461879,19305418,19286130,19149995">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">The residues including 22 to 24 and 34 to 42 of tetherin play a crucial role in the Vpu interaction. I34, L37, and L41 of tetherin are involved in the determination of Vpu susceptibility</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24822052,23919512,22524178,22264038,22180752,21994744,21068238" href="/pubmed/24822052,23919512,22524178,22264038,22180752,21994744,21068238">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 group N Vpu from Togo downregulates both tetherin isoforms. HIV-2 Env, SIVmac Nef, and KSHV K5 target tetherin isoforms with equal efficiency</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24623426" href="/pubmed/24623426">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Biotinylation technique in living cells demonstrates that HIV-1 Vpu-induced ER-to-cytosol retro-translocation of tetherin is first exposed to the cytosol as a dimeric oxidized complex and then becomes deglycosylated and reduces to monomers</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24257748" href="/pubmed/24257748">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Individual Vpu proteins isolated from chronically or acutely infected patients differ substantially in their CD4 and tetherin downregulation function at the cell surface</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24574397,24465210" href="/pubmed/24574397,24465210">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">BiFC assay demonstrates that the cytoplasmic domain (CD) of HIV-1 Vpu physically interacts with both human and rhesus tetherins. The (G/D)DIWK motif in the CD of rhesus tetherin is responsible for the interaction and the functional antagonism by Vpu</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24109238" href="/pubmed/24109238">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu-mediated BST-2 downregulation is critical for HIV-1 replication and propagation in vivo in a beta-TrCP dependent manner, especially at early times post-infection</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24195843" href="/pubmed/24195843">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">The peptide BST2-TM-P1 competes with BST-2 binding to HIV-1 Vpu, resulting in restoration of the BST-2 level at HeLa-Vpu cell surface</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24676648" href="/pubmed/24676648">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Rhesus BST2 inhibits the release of HIV-1 from cells and is resistant to HIV-1 Vpu. Transfer of residues 30-45 of human BST2 into rhesus BST2 is sufficient to confer sensitivity to Vpu</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24227834,22509177,21687426" href="/pubmed/24227834,22509177,21687426">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu interacts with CD317 via its transmembrane region (amino acids 4-27) in living cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24109238,23633949,23514615,22811908,22524177,22180752,21994744,20485522,20434978,20179761" href="/pubmed/24109238,23633949,23514615,22811908,22524177,22180752,21994744,20485522,20434978,20179761">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Alternative translation initiation produces two isoforms of tetherin, l-isoform and s-isoform, which restrict HIV-1 (Vpu-) particle release, but only l-isoform is sentitive to counteraction by Vpu</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24623426,23028328" href="/pubmed/24623426,23028328">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Human-monkey tetherin chimeras reveal that the transmembrane domains (amino acids I33V, I36L, P40L, and T45I) of tetherin are determinants of sensitivity/resistance to Vpu</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24109238,23919512,22553496,21994744,21687426,21176220,20708210,20688520,20485522,20444900,20434978,20201792,19474106,19461879,19214216" href="/pubmed/24109238,23919512,22553496,21994744,21687426,21176220,20708210,20688520,20485522,20444900,20434978,20201792,19474106,19461879,19214216">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">The cytoplasmic tail of HIV-1 Vpu, specifically within the cytoplasmic tail hinge region (amino acids 47-60), are required for downregulation of both human tetherin and gibbon ape leukemia virus envelope (GaLV Env)</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23284757" href="/pubmed/23284757">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Chimeras between the TMD of HIV-1 M Vpu and the cytoplasmic domains of SIVcpzPtt, SIVcpzPts, and SIVgor Vpu proteins are capable of counteracting human tetherin to enhance virion release</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23514615" href="/pubmed/23514615">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">The C-terminal alpha-helix (H2) of HIV-1 Vpu cytoplasmic tail domain (CTD) is sufficient to remove tetherin from sites of viral assembly and is necessary for full tetherin antagonist activity</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23633949" href="/pubmed/23633949">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">The residues Q2, P3, I4, A7, V20, V21, V25, I26, and I27 of the TM domain in HIV-1 Vpu form crosslinks with the residues LLL22-4, G27, I28, L29, P40, L41, I43, F44, T45, and I46 of the TM domain in tetherin</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23633949" href="/pubmed/23633949">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Tetherin is in lipid rafts at the cell surface. Expression of HIV-1 Vpu relocalizes tetherin from the lipid rafts to intracellular endosome and lysosome compartments</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24086611,23633949" href="/pubmed/24086611,23633949">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Amino acid substitution variants of tetherin (Y8H, R19H, N49S, D103N, E117A, D129E and V146L) in human populations maintain its ability to restrict virion release but do not confer resistance to HIV-1 Vpu or SIVtan Env</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23937976" href="/pubmed/23937976">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu proteins from Cameroonian group N viruses are largely unable to downregulate tetherin. Four amino acid substitutions (E15A, V19A and IV25/26LL) in the transmembrane domain of N-Vpu allow efficient interaction with human tetherin</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23308067" href="/pubmed/23308067">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu inhibits endogenous expression BST2-induced NF-kappaB activity in cells, and the inhibition requires the beta-TrCP binding motif (residues 51-56; DSGxxS) in Vpu</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23221546" href="/pubmed/23221546">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu variants from the group C show moderate virus release activity in comparison to group B Vpu variants. The TM domain from the inactive Vpu C is responsible for a significant decrease in egress activity and BST-2 downregulation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23582304,23555649" href="/pubmed/23582304,23555649">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">A combination of molecular dynamics simulations and docking approaches shows the lowest energy structure of Vpu-BST2, indicating that Leu-11/14/19/23 and Ile-10/15/18 in BST2 interact with the alanine rim (Ala-8/11/15/19) of Vpu</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24036078" href="/pubmed/24036078">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Analysis of the chimera HIV-1 Vpu proteins from group M and O shows that alanine-18 is important for group M Vpu localization and tetherin-Vpu interaction</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24075872,23919512,22180752,21955466" href="/pubmed/24075872,23919512,22180752,21955466">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Overexpression of BST2 and downregulation of HIV-1 Vpu in HIV-1 infected TZM-bl cells inhibit HIV-1 replication</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23188559" href="/pubmed/23188559">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">The retention of HIV-1 Vpu from group O in ER-associated compartments confers a defect to antagonism even when interaction with tetherin is mediated through a chimeric TM domain</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24075872,21775465" href="/pubmed/24075872,21775465">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Tetherin delGPI mutant directly interacts with HIV-1 Vpu and inhibits Vpu-induced degradation of tetherin and CD4. Transient expression of tetherin delGPI mutant also inhibits infectious HIV-1 release in tetherin-positive cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23201263" href="/pubmed/23201263">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu downregulates cell-surface BST-2 levels without qualitatively affecting the distribution of the restriction factor at the plasma membrane in HIV-1-infected Jurkat cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24075872,21902775" href="/pubmed/24075872,21902775">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">SCYL2 inhibits Vpu-induced BST2 and CD4 reduction at the cell surface by suppressing the phosphorylation of Vpu at positions Ser-52 and Ser-56</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23047923" href="/pubmed/23047923">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu from chimpanzee-adapted HIV-1 JC16 downregulates both human and chimpanzee tetherin proteins as efficiently as that of HIV-1 NL4-3 Vpu</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22980333" href="/pubmed/22980333">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Alanine-scanning mutagenesis and Ala-to-Leu replacement through the HIV-1 Vpu transmembrane domain (residues 5-28) reveals A14 and W22 are required for tetherin antagonism</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23582304,23284757,22811908,22524177,22264038,22180752,22072710,21775465,20926557" href="/pubmed/23582304,23284757,22811908,22524177,22264038,22180752,22072710,21775465,20926557">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 BF recombinant Vpu is associated with increased viral particle production when compared to WT B variant virus in tetherin-expressing cell lines</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23223624,20920359" href="/pubmed/23223624,20920359">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu rescues the decreased production of infectious HIV-1 virions and restores the diminished reverse transcriptase activities of the culture supernatants as a result of BST-2 inhibition</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23831603,20861258" href="/pubmed/23831603,20861258">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Lysine residues (K18/K21) in tetherin are determinants for Vpu-mediated depletion of tetherin. This depletion, however, is dispenable for potent antagonism of the tetherin-mediated restriction of HIV-1 particle release</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22811908,22553496,22524178,22524177,22180752,21994744,21176220,20980512,20485522,20434978,20147395" href="/pubmed/22811908,22553496,22524178,22524177,22180752,21994744,21176220,20980512,20485522,20434978,20147395">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">A functional ER-associated degradation pathway is required for Vpu-induced tetherin degradation. P97 ATPase (VCP) knockdown partially impairs Vpu-mediated tetherin degradation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23831603,22524180,21176220,19730691" href="/pubmed/23831603,22524180,21176220,19730691">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Tetherin cytoplasmic tail lysine residues (K18 and K21) are ubiquitinated in the presence of HIV-1 Vpu and KSHV K5</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22811908,22383521,21994744,20980512,20485522,20434978,20419159" href="/pubmed/22811908,22383521,21994744,20980512,20485522,20434978,20419159">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu transmembrane domain mutants V9D and I19D fail to promote HIV-1 virion release and to downregulate cell surface tetherin</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22524177,22180752,21994744,21607084" href="/pubmed/22524177,22180752,21994744,21607084">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Mutation of a single amino acid (T45I) in the transmembrane region of BST-2 results in insensitivity to HIV-1 Vpu while maintaining antiviral activity</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23633949,22524177,22264038,21994744,21176220,20485522,20434978,20201792,20012522,19461879" href="/pubmed/23633949,22524177,22264038,21994744,21176220,20485522,20434978,20201792,20012522,19461879">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu co-immunoprecipitates with BST-2 in HEK293T cells and in HeLa Tet-Off cells. Deletion of two leucine residues at positions 22 and 23 in tetherin diminishes its association with Vpu</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23633949,22811908,22553496,22524177,22180752,21994744,21176220,20485522,20434978,20201792,20147395,20012522,19515779,19474106" href="/pubmed/23633949,22811908,22553496,22524177,22180752,21994744,21176220,20485522,20434978,20201792,20147395,20012522,19515779,19474106">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu reduces steady-state expression of BST-2 in transfected HeLa cells and in HIV-infected macrophages, but not in HIV-infected CEMx174 and H9 cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23028328,22180752,21994665,20485522,20434978,20201792,20012522,19461879,19305418,19196977,19149995" href="/pubmed/23028328,22180752,21994665,20485522,20434978,20201792,20012522,19461879,19305418,19196977,19149995">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu-A18H downregulates the expression of BST-2 at the cell surface and enhances virion release inefficiently through a reduced interaction with BST-2</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23919512,21775465,21237475" href="/pubmed/23919512,21775465,21237475">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Tetherin inhibits influenza virus neuraminidase (NA) virus-like particle (VLP) release, which is antagonized by HIV-1 Vpu</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21994744,21209114" href="/pubmed/21994744,21209114">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">In HIV-1-producing cells, CD317 relocalizes predominantly to TfR-positive recycling endosomes, to EEA1-postive early endosomes, and to gin97-positive trans-Golgi network compartments, with some present on late endocytic structures</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23633949,21610122,21176220,20529266,20147389" href="/pubmed/23633949,21610122,21176220,20529266,20147389">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">All potential acceptor sites (Ser3, Thr4, Ser5, Cys9, Lys18, Cys20, and Lys21) in the cytoplasmic domain of BST2 contribute to Vpu-induced ubiquitination</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22524178,22383521,22180752,21994744,20980512" href="/pubmed/22524178,22383521,22180752,21994744,20980512">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">BIT225, HIV-1 Vpu viroporin inhibitor, does not affect Vpu-tetherin interactions</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22110710" href="/pubmed/22110710">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Reduced HIV-1 release in Rab7A-depleted cells is related to expression of the restriction factor tetherin, suggesting that Rab7A contributes to the mechanism by which Vpu counteracts tetherin and rescues HIV-1 release</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22524180,22072966" href="/pubmed/22524180,22072966">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">SHIV Vpu proteins can counteract human and rhesus BST-2</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21775449" href="/pubmed/21775449">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">A computer modeling method predicts that the interface is composed of Vpu residues I6, A10, A14, A18, V25 and W22, and BST-2 residues L23, I26, V30, I34, V35, L41, I42, and T45</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22524177,22264038" href="/pubmed/22524177,22264038">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Endogenous tetherin cell surface expression in T-cell lines H9, CEM-CCRF and CEM-SS are different and that affects HIV-1 Vpu-mediated tetherin modulation on virus release</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21757214" href="/pubmed/21757214">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">An N-terminal deletion and T45I substitution in the TMD of human tetherin render the protein unresponsive to antagonism by HIV-1 Vpu</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22264038,22072710" href="/pubmed/22264038,22072710">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">NMR studies reveal that the 10AXXXAXXXAXXXW22 face of the Vpu transmembrane domain (TMD) directly binds to the large hydrophobic residues (aa 22-47) of the tetherin TMD in an anti-parallel manner</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22524177,22072710" href="/pubmed/22524177,22072710">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">The C-terminal fragment of the clathrin assembly protein AP180 inhibits the downregulation of BST-2 from the cell surface by HIV-1 Vpu and HIV-2 Env</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22479182,21813615" href="/pubmed/22479182,21813615">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Dominant negative dynamin 2 (K44A) acts as an inhibitor of clathrin-mediated endocytosis and that it inhibits the downregulation of BST-2 from the cell surface by HIV-1 Vpu and HIV-2 Env</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21813615" href="/pubmed/21813615">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">The putative cholesterol recognition amino acid consensus (CRAC) motif (residues 25-31) of HIV-1 Vpu mediates lipid raft association of Vpu, but is dispensable for the downregulation of cell surface BST-2</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22222210" href="/pubmed/22222210">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Tetherin expression is upregulated following HIV-1 infection of monocytes-derived macrophages and is not fully downregulated by HIV-1 Vpu</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22980332" href="/pubmed/22980332">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu partially antagonizes the restriction of BST2 on HCV production and release from BST2 expressing Huh7.5 cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22520941" href="/pubmed/22520941">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Downregulation of CD4 and BST2 by HIV-1 Vpu is observed in HIV-1 infected humanized mice</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22357275" href="/pubmed/22357275">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">P40L/T45I mutations in human tetherin leads to drastically decreased susceptibility of the mutant to HIV-1 Vpu, while susceptibility to SIVden Vpu increases to 50%, suggesting that these two residues participate in the species-specific activity of Vpu</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22530020" href="/pubmed/22530020">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Overexpression of clathrin coat-associated protein AP180 inhibits Vpu-mediated tetherin antagonism but adaptor protein-1, adaptor protein-2, and adaptor protein-3 are dispensable</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22479182" href="/pubmed/22479182">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu E/L/V mutants interact with tetherin in infected cells and are incorporated into nascent virions in a tetherin-dependent manner</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22479182" href="/pubmed/22479182">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Mutation of the 59EXXXLV64 motif in HIV-1 Vpu leads to endosomal and surface localization of Vpu and modulates the trafficking of tetherin</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22479182" href="/pubmed/22479182">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">The ubiquitin associated protein 1 (UBAP1)-containing ESCRT-I is essential for degradation of antiviral cell-surface protein such as tetherin (BST-2/CD317) by HIV-1 Vpu</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22811908,22524180,22405001" href="/pubmed/22811908,22524180,22405001">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">IFNalpha/ribavirin treatment in vivo induces APOBEC3G, APOBEC3F, and BST-2 expression and results in hyper-mutations in viral genome and A11G/S61A mutations in HIV-1 Vpu. These two mutations in Vpu enhances the interaction between BST-2 and Vpu</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22315404" href="/pubmed/22315404">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Cholesterol-binding compound amphotericin B methyl ester (AME) inhibits the ability of HIV-1 Vpu to counteract the activity of CD317/BST-2/tetherin</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20201792,20012522,19149577,18653459" href="/pubmed/20201792,20012522,19149577,18653459">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Deletion of amino acids leucine's 22/23 in BST-2 significantly diminishes its association with Vpu, leading to its resistance to antagonism by Vpu</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22811908,22553496,22524177,22180752,20485522,20434978,20201792,20147395,20012522,19474106" href="/pubmed/22811908,22553496,22524177,22180752,20485522,20434978,20201792,20147395,20012522,19474106">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Monomeric tetherin and non-glycosylated tetherin are expressed at the cell surface and are sensitive to Vpu-induced downregulation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20485522,20434978,20201792,20012522,19737401" href="/pubmed/20485522,20434978,20201792,20012522,19737401">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu and beta-TrCP co-immunoprecipitate with tetherin</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22524179,22479182,20980512,20858517,20485522,19730691" href="/pubmed/22524179,22479182,20980512,20858517,20485522,19730691">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">The v-ATPase VPS4 is required for Vpu-induced cell surface downregulation of BST-2</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22524180,21304933" href="/pubmed/22524180,21304933">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HRS interacts with both HIV-1 Vpu and tetherin by co-precipitation analysis</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22524180,22479182,21304933" href="/pubmed/22524180,22479182,21304933">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HRS, an ESCRT-0 complex component, is required for the Vpu-induced downregulation of BST-2, indicating that Vpu-induced BST-2 degradation involves the ESCRT/MVB pathway</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22811908,22524180,22524179,22479182,21304933" href="/pubmed/22811908,22524180,22524179,22479182,21304933">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">Co-depletion of beta-TrCP1 and beta-TrCP2 support Vpu's activity to enhance virus release and to downregulate endogenous tetherin in TZM-bl cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22811908,21310048" href="/pubmed/22811908,21310048">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">The STS sequence in the cytoplasmic domain of BST2 is required for optimal Vpu-mediated downregulation of BST2 from the cell surface and the counteraction of virion release by Vpu</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22524178,20980512" href="/pubmed/22524178,20980512">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu accelerates the turnover of mature endogenous BST-2 in both HeLa and CEMx174 cells. The interference of Vpu with the newly synthesized BST-2 results in the gradual depletion of cell surface BST-2</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21902775,21191020" href="/pubmed/21902775,21191020">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">CD317 exhibits a fast recycling kinetic that is sensitive to treatment with primaquine, a strong recycling inhibitor. HIV-1 Vpu interferes with the recycling of CD317</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21610122" href="/pubmed/21610122">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu ion channel mutant S23A binds and antagonizes CD317, indicating that its ion channel function is not correlated with its ability to downregulate cell surface CD317</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22180752,21601230" href="/pubmed/22180752,21601230">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu cytoplasmic domain mutants S56G and E59K fail to enhance HIV-1 virion release but can reduce cell surface tetherin, suggesting that downregulation of cell surface tetherin and enhancement of virion release by Vpu are not always correlated</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22524178,22180752,21607084" href="/pubmed/22524178,22180752,21607084">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/19172948">capsid</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 CA mutations, P99A and EE75,76AA, pair in tetherin recruitment to HIV-1 assembly sites</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23408603" href="/pubmed/23408603">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
<p class="withnote">
|
||
<a class="note" href="/genome/viruses/retroviruses/hiv-1/interactions/">Go to the HIV-1, Human Interaction Database </a>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-pathways">
|
||
<section class="rprt-section-header" id="pathways">
|
||
<h2 id="header-pathways">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-pathways .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Pathways from PubChem</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<ul class="geneinfo-subsec infopathway">
|
||
<iframe title="Pathways in which the gene target is involved" class="pubchem-widget" scrolling="no" src="https://pubchem.ncbi.nlm.nih.gov/gene/684#section=Pathways&embed=true&hide_all_headings=true&page_size=25" style="border: 0; width: 100%;"></iframe>
|
||
<script type="text/javascript" src="https://pubchem.ncbi.nlm.nih.gov/pcfe/libs/iframeResizer.min.js"></script>
|
||
<script type="text/javascript">iFrameResize({log: false, checkOrigin: false}, '.pubchem-widget')</script>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-interactions">
|
||
<section class="rprt-section-header" id="interactions">
|
||
<h2 id="header-interactions">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-interactions .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Interactions</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Interactions" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<table summary="Gene Interaction" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/684/data/interaction/',webserviceParams: 'p$l=Ajax&p$debugoutput=off', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
|
||
<thead>
|
||
<tr>
|
||
<th id="inter-prod">Products</th>
|
||
<th id="inter-interactant">Interactant</th>
|
||
<th id="inter-otherGene">Other Gene</th>
|
||
<th id="inter-compl">Complex</th>
|
||
<th id="inter-source">Source</th>
|
||
<th id="inter-pubs">Pubs</th>
|
||
<th id="inter-desc">Description</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody></tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-general-gene-info">
|
||
<section class="rprt-section-header" id="general-gene-info">
|
||
<h2 id="header-general-gene-info">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-gene-info .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">General gene information</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.General_Gene_Information" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
|
||
<div class="rprt-section-body" style="">
|
||
<div id="gene-markers">
|
||
<h3 id="markers">
|
||
<a class="jig-ncbitoggler">Markers</a>
|
||
</h3>
|
||
<div>
|
||
<ul class="marker odd">
|
||
<li class="marker">STS-T47132 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=55567%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=684&link_uid=55567">UniSTS:55567</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">RH78341 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=19307%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=684&link_uid=19307">UniSTS:19307</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">STS-R65788 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=58734%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=684&link_uid=58734">UniSTS:58734</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">RH80754 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=89469%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=684&link_uid=89469">UniSTS:89469</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">SHGC-35522 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=34738%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=684&link_uid=34738">UniSTS:34738</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">RH102614 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=96948%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=684&link_uid=96948">UniSTS:96948</a></li></ul></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div></div>
|
||
|
||
<div class="infosec">
|
||
<h3 id="homology">
|
||
<a class="jig-ncbitoggler-open">Homology</a>
|
||
</h3>
|
||
<ul class="geneinfo-subsec">
|
||
<li>
|
||
<a href="/gene/684/ortholog/" id="ncbi-ortholog-link">NCBI Orthologs</a>
|
||
</li>
|
||
<a href="https://www.orthodb.org/?ncbi=684" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=8178" target="_blank">
|
||
Orthologs from OrthoDB
|
||
</a>
|
||
</ul>
|
||
</div>
|
||
|
||
<!--<component id="Gene_InfoPathway"/>-->
|
||
|
||
|
||
<div class="gene-ontology infosec">
|
||
<h3 id="gene-ontology">
|
||
<a class="jig-ncbitoggler-open">
|
||
<span>Gene Ontology</span>
|
||
</a>
|
||
<a target="_blank" href="http://www.ebi.ac.uk/GOA" class="g-ontology-src" title="Provided by GOA">Provided by GOA</a>
|
||
</h3>
|
||
<div class="ontology-tables">
|
||
<div class="ui-ncbigrid-outer-div">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
|
||
<thead>
|
||
<tr>
|
||
<th class="col1">Function</th>
|
||
<th style="width:12%;">Evidence Code</th>
|
||
<th style="width:10%;">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0003723">enables RNA binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> HDA</a>
|
||
<div id="evidence-code-1-0" class="ecode">
|
||
<br />
|
||
<a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a>
|
||
</div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/22658674" target="_blank" title="PubMed ID 22658674" ref="ordinalpos=1&ncbi_uid=684&link_uid=22658674">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0042802">enables identical protein binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
|
||
<div id="evidence-code-2-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/19879838,20880831,20940320" target="_blank" title="PubMed ID 19879838,20880831,20940320" ref="ordinalpos=1&ncbi_uid=684&link_uid=19879838,20880831,20940320">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0008191">enables metalloendopeptidase inhibitor activity</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-3-0" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0008191">enables metalloendopeptidase inhibitor activity</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-4-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/22065321" target="_blank" title="PubMed ID 22065321" ref="ordinalpos=1&ncbi_uid=684&link_uid=22065321">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005515">enables protein binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
|
||
<div id="evidence-code-5-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/19179289,19564354,22065321,22072710,24843023,32296183" target="_blank" title="PubMed ID 19179289,19564354,22065321,22072710,24843023,32296183" ref="ordinalpos=1&ncbi_uid=684&link_uid=19179289,19564354,22065321,22072710,24843023,32296183">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0042803">enables protein homodimerization activity</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
|
||
<div id="evidence-code-6-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/20399176" target="_blank" title="PubMed ID 20399176" ref="ordinalpos=1&ncbi_uid=684&link_uid=20399176">PubMed</a> </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
<div class="ui-ncbigrid-outer-div">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
|
||
<thead>
|
||
<tr>
|
||
<th class="col1">Process</th>
|
||
<th style="width:12%;">Evidence Code</th>
|
||
<th style="width:10%;">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0042113">involved_in B cell activation</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-1-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0051607">involved_in defense response to virus</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-2-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0051607">involved_in defense response to virus</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-3-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/20399176" target="_blank" title="PubMed ID 20399176" ref="ordinalpos=1&ncbi_uid=684&link_uid=20399176">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0045087">involved_in innate immune response</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-4-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0045087">involved_in innate immune response</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-5-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/19036818" target="_blank" title="PubMed ID 19036818" ref="ordinalpos=1&ncbi_uid=684&link_uid=19036818">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0030308">involved_in negative regulation of cell growth</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-6-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/22065321" target="_blank" title="PubMed ID 22065321" ref="ordinalpos=1&ncbi_uid=684&link_uid=22065321">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0030336">involved_in negative regulation of cell migration</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-7-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/22065321" target="_blank" title="PubMed ID 22065321" ref="ordinalpos=1&ncbi_uid=684&link_uid=22065321">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:1901253">involved_in negative regulation of intracellular transport of viral material</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-8-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/19036818,20686043,20943977" target="_blank" title="PubMed ID 19036818,20686043,20943977" ref="ordinalpos=1&ncbi_uid=684&link_uid=19036818,20686043,20943977">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0002737">involved_in negative regulation of plasmacytoid dendritic cell cytokine production</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-9-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/19564354" target="_blank" title="PubMed ID 19564354" ref="ordinalpos=1&ncbi_uid=684&link_uid=19564354">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0045071">involved_in negative regulation of viral genome replication</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-10-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/20943977" target="_blank" title="PubMed ID 20943977" ref="ordinalpos=1&ncbi_uid=684&link_uid=20943977">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0043123">involved_in positive regulation of canonical NF-kappaB signal transduction</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> HMP</a>
|
||
<div id="evidence-code-11-1" class="ecode">
|
||
<br />
|
||
<a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a>
|
||
</div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/12761501" target="_blank" title="PubMed ID 12761501" ref="ordinalpos=1&ncbi_uid=684&link_uid=12761501">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0070665">acts_upstream_of_or_within positive regulation of leukocyte proliferation</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-12-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-12-1" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/7607676" target="_blank" title="PubMed ID 7607676" ref="ordinalpos=1&ncbi_uid=684&link_uid=7607676">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0032956">involved_in regulation of actin cytoskeleton organization</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-13-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
|
||
<div id="evidence-code-13-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0035455">involved_in response to interferon-alpha</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-14-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
|
||
<div id="evidence-code-14-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0035456">involved_in response to interferon-beta</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-15-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
|
||
<div id="evidence-code-15-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0034341">involved_in response to type II interferon</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-16-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
|
||
<div id="evidence-code-16-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0009615">involved_in response to virus</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-17-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-17-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/19036818,20686043,20943977" target="_blank" title="PubMed ID 19036818,20686043,20943977" ref="ordinalpos=1&ncbi_uid=684&link_uid=19036818,20686043,20943977">PubMed</a> </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
<div class="ui-ncbigrid-outer-div">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-config="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
|
||
<thead>
|
||
<tr>
|
||
<th class="col1">Component</th>
|
||
<th style="width:12%;">Evidence Code</th>
|
||
<th style="width:10%;">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005794">is_active_in Golgi apparatus</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-1-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005794">located_in Golgi apparatus</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-2-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0016324">located_in apical plasma membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
|
||
<div id="evidence-code-3-2" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0035577">located_in azurophil granule membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-4-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0009986">is_active_in cell surface</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-5-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0009986">located_in cell surface</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-6-2" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/22072966" target="_blank" title="PubMed ID 22072966" ref="ordinalpos=1&ncbi_uid=684&link_uid=22072966">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0009986">located_in cell surface</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
|
||
<div id="evidence-code-7-2" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005737">colocalizes_with cytoplasm</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-8-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/22065321" target="_blank" title="PubMed ID 22065321" ref="ordinalpos=1&ncbi_uid=684&link_uid=22065321">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0070062">located_in extracellular exosome</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> HDA</a>
|
||
<div id="evidence-code-9-2" class="ecode">
|
||
<br />
|
||
<a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a>
|
||
</div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/19056867,20458337" target="_blank" title="PubMed ID 19056867,20458337" ref="ordinalpos=1&ncbi_uid=684&link_uid=19056867,20458337">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0043231">located_in intracellular membrane-bounded organelle</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-10-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0016020">located_in membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> HDA</a>
|
||
<div id="evidence-code-11-2" class="ecode">
|
||
<br />
|
||
<a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a>
|
||
</div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/19946888" target="_blank" title="PubMed ID 19946888" ref="ordinalpos=1&ncbi_uid=684&link_uid=19946888">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0045121">located_in membrane raft</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-12-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-12-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005771">located_in multivesicular body</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-13-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-13-2" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/22072966" target="_blank" title="PubMed ID 22072966" ref="ordinalpos=1&ncbi_uid=684&link_uid=22072966">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005886">located_in plasma membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-14-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-14-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/19036818,20399176,20686043,20943977" target="_blank" title="PubMed ID 19036818,20399176,20686043,20943977" ref="ordinalpos=1&ncbi_uid=684&link_uid=19036818,20399176,20686043,20943977">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005886">located_in plasma membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-15-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-15-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0098552">located_in side of membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-16-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-16-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-general-protein-info">
|
||
<section class="rprt-section-header" id="general-protein-info">
|
||
<h2 id="header-general-protein-info">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-protein-info .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">General protein information</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.General_Protein_Information" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<dl>
|
||
<dt>Preferred Names</dt>
|
||
<dd>bone marrow stromal antigen 2</dd>
|
||
</dl>
|
||
<dl>
|
||
<dt>Names</dt>
|
||
<dd>BST-2</dd>
|
||
<dd>HM1.24 antigen</dd>
|
||
<dd>NPC-A-7</dd>
|
||
<dd>antiviral factor tetherin</dd>
|
||
</dl>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-reference-sequences">
|
||
<section class="rprt-section-header" id="reference-sequences">
|
||
<h2 id="header-reference-sequences">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-reference-sequences .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">NCBI Reference Sequences (RefSeq)</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.NCBI_Reference_Sequences_RefS" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<p>
|
||
<span class="new-icon">NEW</span>
|
||
<strong>Try the new <a href="/datasets/tables/genes/?table_type=transcripts&ids=684&utm_source=gene&utm_medium=referral&utm_campaign=refseq" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report." data-ga-category="refseq" data-ga-action="click_datasets_link" data-ga-label="transcript_table">Transcript table</a></strong>
|
||
</p>
|
||
<h3 class="genomerefseqs gene_std_toggler" id="refseqset-independent">
|
||
<a class="jig-ncbitoggler-open">RefSeqs maintained independently of Annotated
|
||
Genomes</a>
|
||
</h3>
|
||
<div class="genomerefseqs_slave">
|
||
<p class="desc"> These reference sequences exist independently of genome builds. <a href="#refseq-expl" id="expl-refseg">Explain</a></p>
|
||
<p id="refseq-expl"> These reference sequences are curated independently of the genome
|
||
annotation cycle, so their versions may not match the RefSeq versions in the current
|
||
genome build. Identify version mismatches by comparing the version of the RefSeq in
|
||
this section to the one reported in <a href="#geneGenomic regions, transcripts, and products">Genomic regions,
|
||
transcripts, and products</a> above. </p>
|
||
<h4 id="mrnaandproteins-p34259200">mRNA and Protein(s) </h4>
|
||
<ol>
|
||
<li>
|
||
<p><a href="/nuccore/NM_004335.4">NM_004335.4</a> → <a href="/protein/NP_004326.1">NP_004326.1</a> bone marrow stromal antigen 2 precursor</p>
|
||
<p>
|
||
<a href="/ipg/NP_004326.1/" ref="ncbi_uid=684">See identical proteins and their annotated locations for NP_004326.1</a>
|
||
</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AC010319">AC010319</a>
|
||
</dd>
|
||
<dt>Consensus CDS</dt>
|
||
<dd>
|
||
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS12358.1">CCDS12358.1</a>
|
||
</dd>
|
||
<dt>UniProtKB/Swiss-Prot</dt>
|
||
<dd><a href="https://www.uniprot.org/uniprot/A8K4Y4" ref="itool=Gene_FullReport&PrId=5380&uid=684&nlmid=&db=gene">A8K4Y4</a>, <a href="https://www.uniprot.org/uniprot/Q10589" ref="itool=Gene_FullReport&PrId=5380&uid=684&nlmid=&db=gene">Q10589</a>, <a href="https://www.uniprot.org/uniprot/Q53G07" ref="itool=Gene_FullReport&PrId=5380&uid=684&nlmid=&db=gene">Q53G07</a></dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd>
|
||
<a href="https://www.uniprot.org/uniprot/A0A024R7H5" ref="itool=Gene_FullReport&PrId=5380&uid=684&nlmid=&db=gene">A0A024R7H5</a>
|
||
</dd>
|
||
<dt>Related</dt>
|
||
<dd><a href="http://www.ensembl.org/id/ENSP00000252593.6" ref="itool=Gene_FullReport&PrId=5380&uid=684&nlmid=&db=gene">ENSP00000252593.6</a>, <a href="http://www.ensembl.org/id/ENST00000252593.7" ref="itool=Gene_FullReport&PrId=5380&uid=684&nlmid=&db=gene">ENST00000252593.7</a></dd>
|
||
<dt class="clear"> Conserved Domains (1) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_004326.1">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=318842">pfam16716</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">49</span> → <span class="cddto">133</span></dt>
|
||
<dd class="clearfix"> BST2; Bone marrow stromal antigen 2</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
</div>
|
||
<h3 class="genomerefseqs gene_std_toggler" id="annotatedrefseq-title">
|
||
<a class="jig-ncbitoggler-open">RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08</a>
|
||
</h3>
|
||
<div class="genomerefseqs_slave">
|
||
<p class="desc"> The following sections contain reference sequences that belong to a
|
||
specific genome build. <a href="#" id="expl-genomes">Explain</a></p>
|
||
<p id="expl-genomes-desc" style="display:none">This section includes genomic Reference
|
||
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
|
||
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
|
||
assemblies. Model RNAs and proteins are also reported here.</p>
|
||
<h3 id="refseq-sequencedescription-p113575264">Reference GRCh38.p14 Primary Assembly</h3>
|
||
<h4 id="genomic-p113575264">Genomic </h4>
|
||
<ol>
|
||
<li>
|
||
<p>NC_000019.10 Reference GRCh38.p14 Primary Assembly</p>
|
||
<dl>
|
||
<dt>Range</dt>
|
||
<dd class="rs-range">
|
||
<span>17402939..17405630 complement</span>
|
||
</dd>
|
||
<dt>Download</dt>
|
||
<dd><a href="/nuccore/NC_000019.10?from=17402939&to=17405630&report=genbank&strand=true" ref="ordinalpos=1&ncbi_uid=684&link_uid=NC_000019.10?from=17402939&to=17405630&report=genbank&strand=true">GenBank</a>, <a href="/nuccore/NC_000019.10?from=17402939&to=17405630&report=fasta&strand=true" ref="ordinalpos=1&ncbi_uid=684&link_uid=NC_000019.10?from=17402939&to=17405630&report=fasta&strand=true">FASTA</a>, <a href="/nuccore/NC_000019.10?from=17402534&to=17406033&report=graph&content=5&strand=true" ref="ordinalpos=1&ncbi_uid=684&link_uid=NC_000019.10?from=17402534&to=17406033&report=graph&content=5&strand=true">Sequence Viewer (Graphics)</a></dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
<h3 id="refseq-sequencedescription-p105700256">Alternate T2T-CHM13v2.0</h3>
|
||
<h4 id="genomic-p105700256">Genomic </h4>
|
||
<ol>
|
||
<li>
|
||
<p>NC_060943.1 Alternate T2T-CHM13v2.0</p>
|
||
<dl>
|
||
<dt>Range</dt>
|
||
<dd class="rs-range">
|
||
<span>17537665..17540365 complement</span>
|
||
</dd>
|
||
<dt>Download</dt>
|
||
<dd><a href="/nuccore/NC_060943.1?from=17537665&to=17540365&report=genbank&strand=true" ref="ordinalpos=1&ncbi_uid=684&link_uid=NC_060943.1?from=17537665&to=17540365&report=genbank&strand=true">GenBank</a>, <a href="/nuccore/NC_060943.1?from=17537665&to=17540365&report=fasta&strand=true" ref="ordinalpos=1&ncbi_uid=684&link_uid=NC_060943.1?from=17537665&to=17540365&report=fasta&strand=true">FASTA</a>, <a href="/nuccore/NC_060943.1?from=17537259&to=17540769&report=graph&content=5&strand=true" ref="ordinalpos=1&ncbi_uid=684&link_uid=NC_060943.1?from=17537259&to=17540769&report=graph&content=5&strand=true">Sequence Viewer (Graphics)</a></dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-related-sequences">
|
||
<section class="rprt-section-header" id="related-sequences">
|
||
<h2 id="header-related-sequences">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-related-sequences .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Related sequences</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Related_Sequences" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div>
|
||
<table id="proteinTblId" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/684/data/related-sequences/',webserviceParams: 'p$l=Ajax', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
|
||
<thead>
|
||
<tr>
|
||
<th colspan="2" id="rs-nucleo">Nucleotide</th>
|
||
<th rowspan="2" id="rs-protein">Protein</th>
|
||
</tr>
|
||
<tr>
|
||
<th id="rs-heading">Heading</th>
|
||
<th id="rs-heading-acc">Accession and Version</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody></tbody>
|
||
</table>
|
||
<table id="proteinTblId" class="jig-ncbigrid" data-jigconfig="isPageable:true, pageSize:25">
|
||
<thead>
|
||
<tr>
|
||
<th class="proteinTblTh" rowspan="2" id="rs-prot-acc">Protein Accession</th>
|
||
<th class="proteinTblTh" colspan="2" id="rs-link">Links</th>
|
||
</tr>
|
||
<tr>
|
||
<th id="rs-genepept">GenPept Link</th>
|
||
<th id="rs-uniprot">UniProtKB Link</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="rs-prot-acc">Q10589.1</td>
|
||
<td headers="rs-link rs-genepept">
|
||
<a href="/protein/1705508" ref="ordinalpos=1&ncbi_uid=684&link_uid=1705508">GenPept</a>
|
||
</td>
|
||
<td>
|
||
<a href="https://www.uniprot.org/uniprot/Q10589">UniProtKB/Swiss-Prot:Q10589</a>
|
||
</td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-additional-links">
|
||
|
||
<section class="rprt-section-header" id="additional-links"><h2 id="header-additional-links"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-additional-links .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Additional links</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Additional_Links" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
|
||
|
||
<div class="rprt-section-body" style="">
|
||
|
||
|
||
<h3 class="withnote" id="genelinkout">
|
||
<a class="jig-ncbitoggler">Gene LinkOut</a>
|
||
</h3><div>
|
||
<p>The following <a href="https://www.ncbi.nlm.nih.gov/projects/linkout/index.html">LinkOut</a> resources are supplied by external providers. These providers are responsible for maintaining the links. </p>
|
||
<div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Chemical Information</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>Interologous Interaction Database</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://ophid.utoronto.ca/redirect/ncbi/human?proteins=684" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=7911">
|
||
<span>Interologous Interaction Database</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>MilliporeSigma</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.sigmaaldrich.com/catalog/genes/BST2?lang=en&region=US" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=9978">
|
||
<span>Bst2 products</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Molecular Biology Databases</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>Bgee database</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.bgee.org/gene/ENSG00000130303" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=10418">
|
||
<span>BST2 gene expression</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>BioGPS</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://biogps.org/gene/684/" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=5059">
|
||
<span>BioGPS</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>BioGRID Open Repository of CRISPR Screens (ORCS)</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://orcs.thebiogrid.org/Gene/684" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=10164">
|
||
<span>BioGRID CRISPR Screen Phenotypes (20 hits/1377 screens)</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>Domain Mapping of Disease Mutations</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://bioinf.umbc.edu/DMDM/gene_prot_page.php?id=684" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=7642">
|
||
<span>BST2</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>Eukaryotic Promoter Database</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://epd.vital-it.ch/cgi-bin/get_doc?db=hgEpdNew&format=genome&entry=BST2_1" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=9624">
|
||
<span>BST2_1</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>GlyGen glycoinformatics resource</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://glygen.org/protein/Q10589" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=10227">
|
||
<span>GlyGen glycoinformatics resource</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>Human eFP Browser</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Nervous&modeInput=Absolute&primaryGene=684" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=8875">
|
||
<span>Human eFP Browser</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Skeletal_Immune_Digestive&modeInput=Absolute&primaryGene=684" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=8875">
|
||
<span>Human eFP Browser</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Circulatory_Respiratory&modeInput=Absolute&primaryGene=684" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=8875">
|
||
<span>Human eFP Browser</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li>Ingenuity Pathways Analysis</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://partnersolution.ingenuity.com/?cid=97ae3f91eab87a&p1=Entrez&p2=GV&s=&ipaUri=%2Fpa%2Fapi%2Fv2%2Fgeneview%3Fapplicationname%3DEntrez%26geneId%3D684%26geneidtype%3Dentrezgene" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=5628">
|
||
<span>Ingenuity Pathways Analysis</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>InnateDB</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://www.innatedb.com/getGeneCard.do?id=36619" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=7894">
|
||
<span>InnateDB</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>InterMine</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.humanmine.org/humanmine/search?keyword=ENSG00000130303" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=9169">
|
||
<span>InterMine</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>Kyoto Encyclopedia of Genes and Genomes</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://www.genome.jp/dbget-bin/www_bget?hsa:684" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=5174">
|
||
<span>Kyoto Encyclopedia of Genes and Genomes</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>OMA Browser: Orthologous MAtrix</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN41790/" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=9822">
|
||
<span>OMA Browser: Orthologous MAtrix</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>OrthoDB catalog of orthologs</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.orthodb.org/?ncbi=684" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=8178">
|
||
<span>Orthologs</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>PhosphoSitePlus</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.phosphosite.org/entrezGeneIdAction.action?id=684" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=7987">
|
||
<span>PhosphoSitePlus® - comprehensive post-translational modification resource</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>The Gene Wiki</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://en.wikipedia.org/wiki/BST2" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=6933">
|
||
<span>The Gene Wiki</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>The Weizmann Institute of Science GeneCards and MalaCards databases</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=BST2" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=8598">
|
||
<span>GeneCard for BST2</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Research Materials</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="order-rsc"></span>Addgene Non-profit plasmid repository</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://addgene.org//browse/gene/684" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=5304">
|
||
<span>Get Plasmids - Addgene</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>Bio-Techne</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.bio-techne.com/t/bst-2-tetherin/antibodies?utm_source=linkout&utm_medium=referral&utm_campaign=product&utm_term=antibodies" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=8242">
|
||
<span>BST2 Antibodies</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.bio-techne.com/t/bst-2-tetherin/proteins-enzymes?utm_source=linkout&utm_medium=referral&utm_campaign=product&utm_term=proteins" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=8242">
|
||
<span>BST2 Proteins</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.bio-techne.com/t/bst-2-tetherin/lysates?utm_source=linkout&utm_medium=referral&utm_campaign=product&utm_term=lysates" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=8242">
|
||
<span>BST2 Lysates</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li>ExactAntigen/Labome</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.labome.com/review/gene/human/BST2-antibody.html" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=5753">
|
||
<span>reagent review</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.labome.com/gene/human/BST2-antibody.html" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=5753">
|
||
<span>reagents</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>GenScript latest version of gene cDNA ORF Clone</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://www.genscript.com/gene/684" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=8012">
|
||
<span>GenScript latest version of gene cDNA ORF Clone</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>GeneCopoeia Inc.</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=26&field=5&key=684" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=7255">
|
||
<span>Order TALEN/CRISPR clones</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?tax_id=9606&field=5&prt=16&key=684" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=7255">
|
||
<span>Order miRNA target clones</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=1&field=5&key=684" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=7255">
|
||
<span>Order full-length ORF clone</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>GeneTex Inc</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.genetex.com/Product/Search?geneid=684&type=01&page=1" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=8117">
|
||
<span>Find Quality Antibodies</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>OriGene</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.origene.com/search?q=Bst2" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=7994">
|
||
<span>Order Bst2 cDNA clone/Protein/Antibody/RNAi</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Tools</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>GeneMANIA</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://genemania.org/link?o=9606&g=684" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=7529">
|
||
<span>GeneMANIA</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open">
|
||
<span>Miscellaneous</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>Reactome</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://reactome.org/PathwayBrowser/#/R-HSA-168256" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=4914">
|
||
<span>Reactome Event:Immune System</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://reactome.org/content/query?q=UniProt:Q10589" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=4914">
|
||
<span>Reactome Entity:Q10589</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://reactome.org/PathwayBrowser/#/R-HSA-1643685" ref="itool=Gene_FullReport&uid=684&nlmid=&db=gene&log$=linkoutlink&PrId=4914">
|
||
<span>Reactome Event:Disease</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="urls-in-genombrowser" style="display:none">
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div><input type="hidden" class="section_status_input" name="status_checked" id="status_checked" value="" /><input type="hidden" class="section_status_input" name="status_open" id="status_open" value="summary,region,context,bibliography,phenotypes,variation,hiv,interactions,pathways,geneInfo,proteinInfo,refSeq,related,links" /><input type="hidden" class="section_status_input" name="status_exist" id="status_exist" value="summary,context,region,expression,bibliography,phenotypes,variation,hiv,,interactions,geneInfo,proteinInfo,refSeq,related,links" /><input type="hidden" class="section_status_input" name="status_closed" id="status_closed" value="" /><meta name="status_checked" content="" class="meta_section_status" /><meta name="status_open" content="summary,region,context,bibliography,phenotypes,variation,hiv,interactions,pathways,geneInfo,proteinInfo,refSeq,related,links" class="meta_section_status" /><meta name="status_exist" content="summary,context,region,expression,bibliography,phenotypes,variation,hiv,,interactions,geneInfo,proteinInfo,refSeq,related,links" class="meta_section_status" /><meta name="status_closed" content="" class="meta_section_status" /><script type="text/javascript">
|
||
|
||
var section_status_meta = {
|
||
'status_checked': '',
|
||
'status_open': 'summary,region,context,bibliography,phenotypes,variation,hiv,interactions,pathways,geneInfo,proteinInfo,refSeq,related,links',
|
||
'status_exist': 'summary,context,region,expression,bibliography,phenotypes,variation,hiv,,interactions,geneInfo,proteinInfo,refSeq,related,links',
|
||
'status_closed': ''
|
||
};
|
||
|
||
|
||
/*
|
||
for (var o in section_status_meta) {
|
||
var meta=document.createElement('meta');
|
||
meta.name = o;
|
||
meta.content = section_status_meta[o];
|
||
var attr = document.createAttribute('data-ignore-limit');
|
||
attr.value = 'true';
|
||
meta.setAttributeNode(attr);
|
||
document.getElementsByTagName('head')[0].appendChild(meta);
|
||
}
|
||
*/
|
||
|
||
|
||
var __ncbi_sg_pingCallbacks_render_gene = function (data, evtObj, type) {
|
||
// data looks like {jsevent: "click", "link_id": "foo", ...}
|
||
// evtObj is the JS event object
|
||
// type is either "stat" (for applog) or "ga"
|
||
var extraData = {};
|
||
if (type == "stat") {
|
||
for (var o in section_status_meta) {
|
||
extraData[o] = section_status_meta[o];
|
||
}
|
||
|
||
return extraData;
|
||
|
||
}
|
||
}
|
||
|
||
|
||
</script></div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last" id="sidebar_tabular">
|
||
<!-- sidebar close/hide button-->
|
||
<div class="ui-helper-clearfix">
|
||
<a href="#" id="sidecontent_2_pullout" style="float:right;" class="sidecontentpullout_local collapse_button"><span>Hide sidebar >></span></a>
|
||
</div>
|
||
<!-- end sidebar close/hide button-->
|
||
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div id="gene-sidebar">
|
||
<div>
|
||
<div class="portlet brieflink dis-table-of-contents">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Table of contents</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_TableOfContents" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li class="">
|
||
<a href="#summary">Summary</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#genomic-context">Genomic context</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#genomic-regions-transcripts-products">Genomic regions, transcripts, and products</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#gene-expression">Expression</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#bibliography">Bibliography</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#phenotypes">Phenotypes</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#variation">Variation</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#HIV-1-interactions">HIV-1 interactions</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#pathways">Pathways from PubChem</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#interactions">Interactions</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#general-gene-info">General gene information</a>
|
||
<div class="subsection-links"><a href="#gene-markers">Markers</a>, <a href="#homology">Homology</a>, <a href="#gene-ontology">Gene Ontology</a></div>
|
||
</li>
|
||
<li class="">
|
||
<a href="#general-protein-info">General protein information</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#reference-sequences">NCBI Reference Sequences (RefSeq)</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#related-sequences">Related sequences</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#additional-links">Additional links</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-genomesbrowser brieflink dis-genomesbrowser">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Genome Browsers</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GenomeBrowsers.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GenomeBrowsers" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GenomeBrowsers.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="#">Loading...</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet dis-related-info brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content DiscoveryDbLinks">
|
||
<ul>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clone/order/gene/684" ref="log$=recordlinks">Order cDNA clone</a>
|
||
<div class="brieflinkpop offscreen_noflow">Order cDNA clone</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/structure?LinkName=gene_structure&from_uid=684" ref="log$=recordlinks">3D structures</a>
|
||
<div class="brieflinkpop offscreen_noflow">3D structure of a gene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_alltarget_list&from_uid=684" ref="log$=recordlinks">BioAssay by Target (List)</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioAssays related to the gene by protein target or RNAi target</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="//pubchem.ncbi.nlm.nih.gov/assay/bioactivity.html?geneid=684" ref="log$=recordlinks">BioAssay by Target (Summary)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Summarized PubChem Data on the gene, showing the active data by default</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_target&from_uid=684" ref="log$=recordlinks">BioAssay, by Gene target</a>
|
||
<div class="brieflinkpop offscreen_noflow">PubChem BioAssays done on the Gene target</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai_active&from_uid=684" ref="log$=recordlinks">BioAssays, RNAi Target, Active</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent, which is identified as a hit in a RNAi screening and flagged as "active" in the corresponding BioAssay record</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai&from_uid=684" ref="log$=recordlinks">BioAssays, RNAi Target, Tested</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/bioproject?LinkName=gene_bioproject&from_uid=684" ref="log$=recordlinks">BioProjects</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioProjects related to a gene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/biosystems?LinkName=gene_biosystems&from_uid=684" ref="log$=recordlinks">BioSystems</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioSystems</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/CCDS/CcdsBrowse.cgi?REQUEST=GENEID&DATA=684" ref="log$=recordlinks">CCDS</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to CCDS</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar&from_uid=684" ref="log$=recordlinks">ClinVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/cdd?LinkName=gene_cdd&from_uid=684" ref="log$=recordlinks">Conserved Domains</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related CDD</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/dbvar?LinkName=gene_dbvar&from_uid=684" ref="log$=recordlinks">dbVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link from Gene to dbVar</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc&from_uid=684" ref="log$=recordlinks">Full text in PMC</a>
|
||
<div class="brieflinkpop offscreen_noflow">PMC links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc_nucleotide&from_uid=684" ref="log$=recordlinks">Full text in PMC_nucleotide</a>
|
||
<div class="brieflinkpop offscreen_noflow">Full text in PubMedCentral identified from shared sequence links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/sparcle?LinkName=gene_sparcle&from_uid=684" ref="log$=recordlinks">Functional Class</a>
|
||
<div class="brieflinkpop offscreen_noflow">Functional class of the sequence domain architecture</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gap?LinkName=gene_gap&from_uid=684" ref="log$=recordlinks">GAP</a>
|
||
<div class="brieflinkpop offscreen_noflow">GAP Links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gene?LinkName=gene_gene_neighbors&from_uid=684" ref="log$=recordlinks">Gene neighbors</a>
|
||
<div class="brieflinkpop offscreen_noflow">Overlapping genes and two nearest non-overlapping genes on either side</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/genome?LinkName=gene_genome&from_uid=684" ref="log$=recordlinks">Genome</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related Genome</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/geoprofiles?LinkName=gene_geoprofiles&from_uid=684" ref="log$=recordlinks">GEO Profiles</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related GEO</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests/?term=684[geneid]" ref="log$=recordlinks">GTR</a>
|
||
<div class="brieflinkpop offscreen_noflow">Tests for this gene in the NIH Genetic Testing Registry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/homologene?LinkName=gene_homologene&from_uid=684" ref="log$=recordlinks">HomoloGene</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related HomoloGene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore&from_uid=684" ref="log$=recordlinks">Nucleotide</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related Nucleotide entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/omim?LinkName=gene_omim&from_uid=684" ref="log$=recordlinks">OMIM</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related OMIM entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/probe?LinkName=gene_probe&from_uid=684" ref="log$=recordlinks">Probe</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related Probe entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein&from_uid=684" ref="log$=recordlinks">Protein</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related protein entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pccompound?LinkName=gene_pccompound&from_uid=684" ref="log$=recordlinks">PubChem Compound</a>
|
||
<div class="brieflinkpop offscreen_noflow">PubChem Compounds</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcsubstance?LinkName=gene_pcsubstance&from_uid=684" ref="log$=recordlinks">PubChem Substance</a>
|
||
<div class="brieflinkpop offscreen_noflow">PubChem Substances</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed&from_uid=684" ref="log$=recordlinks">PubMed</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related PubMed entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_rif&from_uid=684" ref="log$=recordlinks">PubMed (GeneRIF)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related PubMed article from GeneRIFs</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_citedinomim&from_uid=684" ref="log$=recordlinks">PubMed (OMIM)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Gene links to PubMed derived from omim_pubmed_cited links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_pmc_nucleotide&from_uid=684" ref="log$=recordlinks">PubMed(nucleotide/PMC)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Citations in PubMed identified from shared sequence and PMC links.</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein_refseq&from_uid=684" ref="log$=recordlinks">RefSeq Proteins</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to Protein RefSeqs</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore_refseqrna&from_uid=684" ref="log$=recordlinks">RefSeq RNAs</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to Nucleotide RefSeq RNAs</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar_specific&from_uid=684" ref="log$=recordlinks">Related gene-specific medical variations</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/taxonomy?LinkName=gene_taxonomy&from_uid=684" ref="log$=recordlinks">Taxonomy</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related taxonomy entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/variation/view/?q=684[geneid]" ref="log$=recordlinks">Variation Viewer</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related Variants</div>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet dis-links-to-other-res brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Links to other resources</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_LinksTwo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1119">HGNC</a>
|
||
</li>
|
||
<li>
|
||
<a href="http://www.ensembl.org/id/ENSG00000130303">Ensembl</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.alliancegenome.org/gene/HGNC:1119">AllianceGenome</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=geneid&org=9606&l=684">AceView</a>
|
||
</li>
|
||
<li>
|
||
<a href="http://www.pharmgkb.org/gene/PA25436">PharmGKB</a>
|
||
</li>
|
||
<li>
|
||
<a href="http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_004335">UCSC</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://genecollections.nci.nih.gov/MGC/?ORG=Hs&LIST=BC033873">MGC</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://phgkb.cdc.gov/PHGKB/huGEPedia.action?firstQuery=BST2&geneID=684&typeOption=gene&which=2&pubOrderType=pubD&typeSubmit=GO&check=y">HuGE Navigator</a>
|
||
</li>
|
||
<li>
|
||
<a href="http://www.genome.jp/dbget-bin/www_bget?hsa:684">KEGG</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://reactome.org/content/query?q=UniProt:Q10589">Reactome</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-general-info">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>General information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GeneralInfo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="/pmc/?term=PMC4383897+OR+PMC3013746+OR+PMC1761442+OR+PMC539985">About Gene</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK3840">FAQ</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://ftp.ncbi.nlm.nih.gov/gene/">FTP site</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK3841/">Help</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK3842/">My NCBI help</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK21085/">NCBI Handbook</a>
|
||
</li>
|
||
<li>
|
||
<a href="/gene/statistics/">Statistics</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-related-sites">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related sites</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_RelatedSites" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/BLAST">BLAST</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/genome">Genome</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/bioproject">BioProject</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/genome/gdv/">Genome Data Viewer</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/geo">GEO</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/omim">OMIM</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/probe">Probe</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/RefSeq">RefSeq</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-feedback">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Feedback</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_Feedback" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="https://support.ncbi.nlm.nih.gov/ics/support/ticketnewwizard.asp?style=classic&deptID=28049">Contact Help Desk</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/RefSeq/update.cgi?geneid=684&symbol=BST2">Submit Correction</a>
|
||
</li>
|
||
<li>
|
||
<a href="/gene/submit-generif?geneId=684&sym=BST2&name=bone marrow stromal cell antigen 2&org=Homo sapiens">Submit GeneRIF</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-subscription">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Subscription</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Subscription.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_Subscription" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Subscription.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/mailman/listinfo/refseq-announce">RefSeq</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<!-- <component id="Gene_RVFullReport.Gene_RightColMenuLinks"/>-->
|
||
<div class="portlet">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Recent activity</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="recent_activity" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
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<div id="HTDisplay" class="">
|
||
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|
||
<div class="action">
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.ClearHistory" sid="1" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.ClearHistory" cmd="ClearHT" href="?cmd=ClearHT&" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.ClearHistory">
|
||
Clear
|
||
</a>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" sid="1" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOn" cmd="HTOff" href="?cmd=HTOff&" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle">
|
||
Turn Off
|
||
</a>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" sid="2" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOff" cmd="HTOn" href="?cmd=HTOn&" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle">
|
||
Turn On
|
||
</a>
|
||
</div>
|
||
<ul id="activity">
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67c9e93a84f3725e596f91e5">BST2 bone marrow stromal cell antigen 2 [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">BST2 bone marrow stromal cell antigen 2 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:684</div></div>
|
||
<div class="tertiary">Gene</div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67c9e938f4a390645e708732">bone marrow stromal antigen 2 precursor [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">bone marrow stromal antigen 2 precursor [Homo sapiens]<div class="brieflinkpopdesc">gi|4757876|ref|NP_004326.1|</div></div>
|
||
<div class="tertiary">Protein</div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67c9e93384f3725e596f6a42">BSG basigin (Ok blood group) [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">BSG basigin (Ok blood group) [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:682</div></div>
|
||
<div class="tertiary">Gene</div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67c9e930b15b832ebc417eb1">basigin isoform 1 precursor [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">basigin isoform 1 precursor [Homo sapiens]<div class="brieflinkpopdesc">gi|38372919|ref|NP_001719.2|</div></div>
|
||
<div class="tertiary">Protein</div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67c9e92fa68b6b5afca59270">bcl-2-like protein 1 isoform Bcl-X(L) [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">bcl-2-like protein 1 isoform Bcl-X(L) [Homo sapiens]<div class="brieflinkpopdesc">gi|20336335|ref|NP_612815.1|</div></div>
|
||
<div class="tertiary">Protein</div>
|
||
</li>
|
||
</ul>
|
||
<p class="HTOn">Your browsing activity is empty.</p>
|
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<p class="HTOff">Activity recording is turned off.</p>
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<p id="turnOn" class="HTOff">
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<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryOn" sid="1" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryOn" cmd="HTOn" href="?cmd=HTOn&" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryOn">Turn recording back on</a>
|
||
</p>
|
||
<a class="seemore" href="/sites/myncbi/recentactivity">See more...</a>
|
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