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<div class="search"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="pubmed">PubMed</option><option value="clinvar">ClinVar</option><option value="medgen">MedGen</option><option value="books" class="last">Books</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly" data-ac_dict="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene" selected="selected" data-ac_dict="gene">Gene</option><option value="genome" data-ac_dict="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen">MedGen</option><option value="mesh">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore" data-ac_dict="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein" data-ac_dict="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search Gene. Use up and down arrows to choose an item from the autocomplete." value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="dictionary:'gene',disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'yes',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div><ul class="searchlinks inline_list"><set></set><li><a href="/gene/advanced">Advanced</a></li><li class="help"><a id="help" class="jig-ncbihelpwindow" target="ncbihelp" name="help" href="/books/NBK3841/">Help</a></li></ul></div>
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<div class="facet_cont" data-db="gene" data-default_grps="fg_gene-sources,fg_categories,fg_sequence-content,fg_status" data-sd="db:'gene',op:'select',term:'',qk:'2674',linkname:'',idsfromresult:'658',extra:''"><ul class="facet" data-filter_id="gene-sources" id="_gene-sources"><li class="filter_grp "><div class="clearfix"><h3>Gene sources</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="genomic">Genomic</a></li></ul></li></ul><ul class="facet" data-filter_id="categories" id="_categories"><li class="filter_grp "><div class="clearfix"><h3>Categories</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="alt-splicing">Alternatively spliced</a></li><li class="fil_val"><a href="#" data-value_id="annotated-genes">Annotated genes</a></li><li class="fil_val"><a href="#" data-value_id="gene-type-protein-coding">Protein-coding</a></li></ul></li></ul><ul class="facet" data-filter_id="sequence-content" id="_sequence-content"><li class="filter_grp "><div class="clearfix"><h3>Sequence content</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="seq-ccds">CCDS</a></li><li class="fil_val"><a href="#" data-value_id="seq-ensembl">Ensembl</a></li><li class="fil_val"><a href="#" data-value_id="refseq">RefSeq</a></li><li class="fil_val"><a href="#" data-value_id="seq-refseqgene">RefSeqGene</a></li></ul></li></ul><ul class="facet" data-filter_id="status" id="_status"><li class="filter_grp "><div class="clearfix"><h3>Status</h3><a href="#" data-value_id="" class="clear clear_show">Clear</a></div><ul><li class="fil_val selected"><a href="#" data-value_id="current-only">Current</a><span class="fcount">(1)</span></li></ul></li></ul><div id="chr-location-facet-wrapper" data-bid="MCID_67c9d714d74f6769103e27be" data-hid="MCID_67c90f2d64f30b25346ccae2" data-qky="2674" class="disabled" style="display:none"><ul class="facet" data-filter_id="chromosomal-region" id="_chromosomal-region" data-of="yes"><li class="filter_grp of_grp"><div class="clearfix"><h3>Chromosome locations</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><a id="facet_ofchromosomal-region" href="#facet_of_divchromosomal-region" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'middle left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '375px'" data-value_id="fetch_more">more...</a><div id="facet_of_divchromosomal-region" style="display:none;" class="of_popup"><h4>Chromosome locations</h4><label for="organism-filter" style="width:100%;margin-bottom:.2em;" class="">Select an organism by typing or scrolling</label><input type="text" placeholder="Enter text to narrow down the list" id="organism-filter" style="width:98%;" autocomplete="off" /><br /><div id="chr-region-tax-list"><select id="of_chromosomal-region" size="9" class="chr-region-tax-list" style="width:100%;"></select></div><div id="chr-location-info-ctrl" data-disabled="disabled"><div class="chr-field"><label for="chr-name">Chromosome</label><br /><select id="chr-name" class="chr-field" disabled="disabled"></select></div><div class="chr-field"><label for="chr-from">From</label><br /><input type="text" name="chr-from" id="chr-from" disabled="disabled" class="chr-field" /></div><div class="chr-field"><label for="chr-to">To</label><br /><input type="text" name="chr-to" id="chr-to" disabled="disabled" class="chr-field" /></div></div><div class="actions clearfix"><button class="jig-ncbibutton of_add apply-chr" data-jigconfig="'color': 'ui-ncbibutton-blue'">Apply</button></div></div></ul></li></ul></div><ul class="facet facet_reset"><li><a href="#" data-value_id="reset">Clear all</a></li></ul><ul class="facet_tools"><li><a id="more_filter_groups_link" href="#more_filter_groups" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'top left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '180px'">
Show additional filters</a></li><div id="more_filter_groups" style="display:none;" class="facets_dialog"><button class="ui-ncbipopper-close-button ui-ncbipopper-close-button-generated ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-blue" generated="true" role="button" aria-disabled="false"><span class="ui-button-text">x</span></button><h4>Additional filters</h4><ul class="filter_groups_more facet"><li><input type="checkbox" id="fg_gene-sources" /><label for="fg_gene-sources">Gene sources</label></li><li><input type="checkbox" id="fg_categories" /><label for="fg_categories">Categories</label></li><li><input type="checkbox" id="fg_sequence-content" /><label for="fg_sequence-content">Sequence content</label></li><li><input type="checkbox" id="fg_status" /><label for="fg_status">Status</label></li><li><input type="checkbox" id="fg_chromosomal-region" /><label for="fg_chromosomal-region">Chromosome locations</label></li><li><input id="fg_field_search" type="checkbox" /><label for="fg_field_search">Search fields</label></li></ul><div class="actions clearfix"><button class="filter_groups_more_apply jig-ncbibutton primary-action" id="filter_groups_apply" data-jigconfig="'color': 'ui-ncbibutton-blue'">Show</button></div></div></ul><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetsUrlFrag" sid="1" type="hidden" value="filters=current-only" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetSubmitted" sid="1" type="hidden" value="false" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.BMFacets" sid="1" type="hidden" value="" /></div>
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<h1 class="title" id="gene-name"><span class="gn" style="padding-right:.5em;">BMPR1B</span> bone morphogenetic protein receptor type 1B [ <em class="tax">Homo sapiens</em> (human)
]
</h1>
<span class="geneid">Gene ID: 658, updated on
4-Mar-2025</span>
</div>
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<div class="rprt-section gene-summary">
<section class="rprt-section-header" id="summary">
<h2 id="header-summary">
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<dl id="summaryDl">
<dt class="noline"> Official
Symbol</dt>
<dd class="noline">BMPR1B<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
<dt> Official
Full Name</dt>
<dd>bone morphogenetic protein receptor type 1B<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
<dt>Primary source</dt>
<dd>
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1077" data-gblink-text="Ensembl">HGNC:HGNC:1077</a>
</dd>
<dt>See related</dt>
<dd>
<a href="http://www.ensembl.org/id/ENSG00000138696" data-gblink-text="Ensembl" class="genome-browser-link" data-genome-browser-link-sort="5" data-gb-url="http://www.ensembl.org/loc/ENSG00000138696">Ensembl:ENSG00000138696</a>
<a href="https://www.ncbi.nlm.nih.gov/omim/603248" data-gblink-text="Ensembl" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=603248">MIM:603248;</a>
<a href="https://www.alliancegenome.org/gene/HGNC:1077" data-gblink-text="Ensembl" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=HGNC:1077">AllianceGenome:HGNC:1077</a>
</dd>
<dt>Gene type</dt>
<dd>protein coding</dd>
<dt>RefSeq status</dt>
<dd>REVIEWED</dd>
<dt>Organism</dt>
<dd class="tax">
<a href="/Taxonomy/Browser/wwwtax.cgi?id=9606" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=9606">Homo sapiens</a>
</dd>
<dt>Lineage</dt>
<dd class="tax">Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo</dd>
<dt>Also known as</dt>
<dd>ALK6; AMD3; AMDD; BDA2; ALK-6; BDA1D; CDw293</dd>
<dt>Summary</dt>
<dd>This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]</dd>
<dt>Expression</dt>
<dd>Biased expression in prostate (RPKM 14.5), brain (RPKM 5.7) and 7 other tissues <a href="#gene-expression">See more</a></dd>
<dt>Orthologs</dt>
<dd class="ortholog-links">
<a href="https://www.ncbi.nlm.nih.gov/gene/12167">mouse</a>
<a href="/gene/658/ortholog/">all</a>
</dd>
<dt style="padding-top:.5em;">
<span class="new-icon">NEW</span>
</dt>
<dd style="padding-top:.5em;">
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/658/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="gene_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Gene table</a></strong>
<br />
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/658/products/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="transcript_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Transcript table</a></strong>
</dd>
</dl>
</div>
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<div class="rprt-section gene-genomic-context">
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</section>
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<div class="gc_cont">
<div class="gt_cont_contents">
<div style="float:right"><span>See BMPR1B in </span><a href="/genome/gdv/?context=gene&amp;acc=658" class="link-to-gdv genome-browser-link" data-genome-browser-link-sort="1" data-acc="GCF_000001405.40">Genome Data Viewer</a> </div>
<dl class="dl-chr-info" style="float:left;margin-top:0;">
<dt>Location: </dt>
<dd>
<span style="display:inline-block;">4q22.3</span>
</dd>
</dl>
</div>
<dl class="dl-chr-info exon-count">
<dt>Exon count: </dt>
<dd>21</dd>
</dl>
<div class="ui-ncbigrid-outer-div" id="genomic-context-tbl-location">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="">
<thead>
<tr>
<th style="max-width:15%">Annotation release</th>
<th style="max-width:10%">Status</th>
<th>Assembly</th>
<th>
<span title="Chromosome">Chr</span>
</th>
<th>Location</th>
</tr>
</thead>
<tbody>
<tr>
<td>RS_2024_08</td>
<td>current</td>
<td>GRCh38.p14 (<a href="/assembly/GCF_000001405.40/" ref="ncbi_uid=658&amp;link_uid=GCF_000001405.40">GCF_000001405.40</a>)</td>
<td>4</td>
<td>NC_000004.12 (94757955..95158450) </td>
</tr>
<tr>
<td>RS_2024_08</td>
<td>current</td>
<td>T2T-CHM13v2.0 (<a href="/assembly/GCF_009914755.1/" ref="ncbi_uid=658&amp;link_uid=GCF_009914755.1">GCF_009914755.1</a>)</td>
<td>4</td>
<td>NC_060928.1 (98073083..98473123) </td>
</tr>
<tr>
<td>RS_2024_09</td>
<td>previous assembly</td>
<td>GRCh37.p13 (<a href="/assembly/GCF_000001405.25/" ref="ncbi_uid=658&amp;link_uid=GCF_000001405.25">GCF_000001405.25</a>)</td>
<td>4</td>
<td>NC_000004.11 (95679106..96079601) </td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<p class="withnote margin_t2em"><strong>Chromosome 4 - NC_000004.12</strong><img usemap="#nbrMap658_568815594" border="0" alt="Genomic Context describing neighboring genes" src="/gutils/geneneighb.fcgi?geneid=658&amp;nuc_gi=568815594&amp;n0=LOC129992844&amp;n1=PDLIM5&amp;n2=LOC129992845&amp;n3=LOC129661309&amp;n4=LOC127401225&amp;n5=LOC127401226&amp;n6=LOC110121104&amp;n7=BMPR1B-DT&amp;n8=BMPR1B&amp;n9=LOC127401227&amp;n10=LOC124900735&amp;n11=UNC5C&amp;n12=LOC126807113&amp;n13=LOC123477790&amp;n14=LOC127401228&amp;n15=LOC127401229&amp;n16=LOC124900736&amp;n17=UNC5C-AS1&amp;n18=LOC129992846&amp;n19=LOC126807114" /><map name="nbrMap658_568815594" id="nbrMap658_568815594">
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 15575')" onMouseOut="hidetip()" coords="2,23,72,31" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15575" href="/gene/129992845" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 15574')" onMouseOut="hidetip()" coords="2,35,72,43" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15574" href="/gene/129992844" />
<area shape="rect" onMouseOver="showtip(this,event,'ReSE screen-validated silencer GRCh37_chr4:95417748-95417936')" onMouseOut="hidetip()" coords="16,47,86,55" alt="Neighboring gene ReSE screen-validated silencer GRCh37_chr4:95417748-95417936" href="/gene/129661309" />
<area shape="rect" onMouseOver="showtip(this,event,'NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:95455489-95456413')" onMouseOut="hidetip()" coords="28,59,98,67" alt="Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:95455489-95456413" href="/gene/127401225" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:95456414-95457337')" onMouseOut="hidetip()" coords="28,71,98,79" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:95456414-95457337" href="/gene/127401226" />
<area shape="rect" onMouseOver="showtip(this,event,'PDZ and LIM domain 5')" onMouseOut="hidetip()" coords="32,83,132,91" alt="Neighboring gene PDZ and LIM domain 5" href="/gene/10611" />
<area shape="rect" onMouseOver="showtip(this,event,'VISTA enhancer hs1438')" onMouseOut="hidetip()" coords="70,95,140,103" alt="Neighboring gene VISTA enhancer hs1438" href="/gene/110121104" />
<area shape="rect" onMouseOver="showtip(this,event,'BMPR1B divergent transcript')" onMouseOut="hidetip()" coords="109,23,164,31" alt="Neighboring gene BMPR1B divergent transcript" href="/gene/100507012" />
<area shape="rect" onMouseOver="showtip(this,event,'NANOG hESC enhancer GRCh37_chr4:95837674-95838175')" onMouseOut="hidetip()" coords="149,47,219,55" alt="Neighboring gene NANOG hESC enhancer GRCh37_chr4:95837674-95838175" href="/gene/127401227" />
<area shape="rect" onMouseOver="showtip(this,event,'uncharacterized LOC124900735')" onMouseOut="hidetip()" coords="195,23,265,31" alt="Neighboring gene uncharacterized LOC124900735" href="/gene/124900735" />
<area shape="rect" onMouseOver="showtip(this,event,'CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:96140095-96141294')" onMouseOut="hidetip()" coords="244,47,314,55" alt="Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:96140095-96141294" href="/gene/126807113" />
<area shape="rect" onMouseOver="showtip(this,event,'Sharpr-MPRA regulatory region 12130')" onMouseOut="hidetip()" coords="256,59,326,67" alt="Neighboring gene Sharpr-MPRA regulatory region 12130" href="/gene/123477790" />
<area shape="rect" onMouseOver="showtip(this,event,'unc-5 netrin receptor C')" onMouseOut="hidetip()" coords="262,71,411,79" alt="Neighboring gene unc-5 netrin receptor C" href="/gene/8633" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr4:96321208-96321708')" onMouseOut="hidetip()" coords="302,23,372,31" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:96321208-96321708" href="/gene/127401228" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr4:96321709-96322209')" onMouseOut="hidetip()" coords="302,35,372,43" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:96321709-96322209" href="/gene/127401229" />
<area shape="rect" onMouseOver="showtip(this,event,'uncharacterized LOC124900736')" onMouseOut="hidetip()" coords="302,83,372,91" alt="Neighboring gene uncharacterized LOC124900736" href="/gene/124900736" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 21730')" onMouseOut="hidetip()" coords="349,47,419,55" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21730" href="/gene/129992846" />
<area shape="rect" onMouseOver="showtip(this,event,'BRD4-independent group 4 enhancer GRCh37_chr4:96506064-96507263')" onMouseOut="hidetip()" coords="353,59,423,67" alt="Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:96506064-96507263" href="/gene/126807114" />
<area shape="rect" onMouseOver="showtip(this,event,'UNC5C antisense RNA 1')" onMouseOut="hidetip()" coords="364,95,423,103" alt="Neighboring gene UNC5C antisense RNA 1" href="/gene/105377335" />
</map>
</p>
</div>
</div>
<div class="rprt-section gene-genomic-regions-transcripts-products">
<section class="rprt-section-header" id="genomic-regions-transcripts-products">
<h2 id="header-genomic-regions-transcripts-products">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-regions-transcripts-products .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Genomic regions, transcripts, and products</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Genomic_Regions_Transcripts_a" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<div style="text-align:right;">Go to <a href="#reference-sequences">reference sequence details</a></div>
</div>
<div>
<p class="choose">
<label for="accession" class="label">Genomic Sequence: </label>
<select name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.accessionList" sid="1" id="accessionList" data-taxid="9606" data-geneid="658">
<option value="NC_000004.12_94757954_95158449">NC_000004.12 Chromosome 4 Reference GRCh38.p14 Primary Assembly</option>
<option value="NG_009245.1_4978_405471">NG_009245.1 RefSeqGene</option>
<option value="NC_060928.1_98073082_98473122">NC_060928.1 Chromosome 4 Alternate T2T-CHM13v2.0</option>
<option value="NC_000004.11_95679105_96079600">NC_000004.11 Chromosome 4 Reference GRCh37.p13 Primary Assembly</option>
</select>
</p>
</div>
<div id="NC_000004" class="divAccession">
<div class="seq-viewer">
<p class="note-link">
<strong>Go to nucleotide:</strong>
<a title="Nucleotide Graphic report" href="/nuccore/NC_000004.12?report=graph&amp;from=94697880&amp;to=95218523&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=NC_000004.12">Graphics</a>
<a title="Nucleotide FASTA report" href="/nuccore/NC_000004.12?report=fasta&amp;from=94757955&amp;to=95158450" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=NC_000004.12">FASTA</a>
<a title="Nucleotide GenBank report" href="/nuccore/NC_000004.12?report=genbank&amp;from=94757955&amp;to=95158450" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=NC_000004.12">GenBank</a>
</p>
<div id="divNC_000004" class="SeqViewerApp" style="clear:both;" data-sv="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000004.12&amp;from=94697880&amp;to=95218523&amp;app_context=Gene&amp;assm_context=GCF_000001405.40">
<a href="?appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000004.12&amp;from=94697880&amp;to=95218523&amp;app_context=Gene&amp;assm_context=GCF_000001405.40"></a>
</div>
</div>
</div>
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000004.12" sid="1" type="hidden" id="nucleotideLink_NC_000004_12_94757954_95158449" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_000004.12?report=graph&amp;amp;from=94697880&amp;amp;to=95218523&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.40&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=658&amp;amp;link_uid=NC_000004.12&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_000004.12?report=fasta&amp;amp;from=94757955&amp;amp;to=95158450&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=658&amp;amp;link_uid=NC_000004.12&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_000004.12?report=genbank&amp;amp;from=94757955&amp;amp;to=95158450&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=658&amp;amp;link_uid=NC_000004.12&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000004.12" sid="1" type="hidden" id="relString_NC_000004_12_94757954_95158449" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_000004.12&amp;amp;from=94697880&amp;amp;to=95218523&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.40" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NG_009245.1" sid="1" type="hidden" id="nucleotideLink_NG_009245_1_4978_405471" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NG_009245.1?report=graph&amp;amp;from=1&amp;amp;to=465545&amp;amp;tracks=[key:sequence_track,name:Sequence,display_name:Sequence,category:Sequence,annots:Sequence,ShowLabel:false][key:gene_model_track,name:Genes---Unnamed,display_name:Genes,annots:Unnamed,Options:ShowAllButGenes,SNPs:false,CDSProductFeats:false,ShowLabelsForAllFeatures:true,HighlightMode:2][key:SNP_track,name:SNP,annots:SNP,Layout:Adaptive][key:SNP_Bins_track,name:Clinical Variants][key:SNP_Bins_track,name:Cited Variants][key:GWAS_track,name:GWAS Tracks,display_name:Association Results][key:alignment_track,category:Alignments,annots:Unnamed][key:alignment_track,category:Alignments,annots:NA000079160.1][key:alignment_track,category:Alignments,annots:NA000010065.1]&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=658&amp;amp;link_uid=NG_009245.1&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NG_009245.1?report=fasta&amp;amp;from=4979&amp;amp;to=405472&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=658&amp;amp;link_uid=NG_009245.1&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NG_009245.1?report=genbank&amp;amp;from=4979&amp;amp;to=405472&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=658&amp;amp;link_uid=NG_009245.1&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NG_009245.1" sid="1" type="hidden" id="relString_NG_009245_1_4978_405471" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NG_009245.1&amp;amp;from=1&amp;amp;to=465545&amp;amp;tracks=[key:sequence_track,name:Sequence,display_name:Sequence,category:Sequence,annots:Sequence,ShowLabel:false][key:gene_model_track,name:Genes---Unnamed,display_name:Genes,annots:Unnamed,Options:ShowAllButGenes,SNPs:false,CDSProductFeats:false,ShowLabelsForAllFeatures:true,HighlightMode:2][key:SNP_track,name:SNP,annots:SNP,Layout:Adaptive][key:SNP_Bins_track,name:Clinical Variants][key:SNP_Bins_track,name:Cited Variants][key:GWAS_track,name:GWAS Tracks,display_name:Association Results][key:alignment_track,category:Alignments,annots:Unnamed][key:alignment_track,category:Alignments,annots:NA000079160.1][key:alignment_track,category:Alignments,annots:NA000010065.1]" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_060928.1" sid="1" type="hidden" id="nucleotideLink_NC_060928_1_98073082_98473122" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_060928.1?report=graph&amp;amp;from=98013076&amp;amp;to=98533128&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_009914755.1&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=658&amp;amp;link_uid=NC_060928.1&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_060928.1?report=fasta&amp;amp;from=98073083&amp;amp;to=98473123&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=658&amp;amp;link_uid=NC_060928.1&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_060928.1?report=genbank&amp;amp;from=98073083&amp;amp;to=98473123&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=658&amp;amp;link_uid=NC_060928.1&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_060928.1" sid="1" type="hidden" id="relString_NC_060928_1_98073082_98473122" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_060928.1&amp;amp;from=98013076&amp;amp;to=98533128&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_009914755.1" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000004.11" sid="1" type="hidden" id="nucleotideLink_NC_000004_11_95679105_96079600" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_000004.11?report=graph&amp;amp;from=95619031&amp;amp;to=96139674&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.25&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=658&amp;amp;link_uid=NC_000004.11&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_000004.11?report=fasta&amp;amp;from=95679106&amp;amp;to=96079601&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=658&amp;amp;link_uid=NC_000004.11&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_000004.11?report=genbank&amp;amp;from=95679106&amp;amp;to=96079601&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=658&amp;amp;link_uid=NC_000004.11&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000004.11" sid="1" type="hidden" id="relString_NC_000004_11_95679105_96079600" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_000004.11&amp;amp;from=95619031&amp;amp;to=96139674&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.25" />
</div>
</div>
<div class="rprt-section gene-gene-expression">
<section class="rprt-section-header" id="gene-expression">
<h2 id="header-gene-expression">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-gene-expression .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Expression</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Expression" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<div style="text-align:right;">
<a href="/gene/658/?report=expression" data-url="/gene/658/?report=expression" id="gene-expression-see-details">See details</a>
</div>
<div id="gene-expression-app" data-url="https://www.ncbi.nlm.nih.gov/gene/658" data-report-type="summary">
<div>
<script type="text/javascript">
window.tissues_data = {'adrenal 10wk': {'id': '658_Adrenal_10wk_PRJNA270632', 'gene': 658, 'source_name': 'adrenal 10wk', 'full_rpkm': 2.14741, 'exp_rpkm': 2.15, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388628062213}, 'adrenal 16wk': {'id': '658_Adrenal_16wk_PRJNA270632', 'gene': 658, 'source_name': 'adrenal 16wk', 'full_rpkm': 1.43611, 'exp_rpkm': 1.44, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388628062214}, 'adrenal 18wk': {'id': '658_Adrenal_18wk_PRJNA270632', 'gene': 658, 'source_name': 'adrenal 18wk', 'full_rpkm': 1.31876, 'exp_rpkm': 1.32, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388628062215}, 'adrenal 20wk': {'id': '658_Adrenal_20wk_PRJNA270632', 'gene': 658, 'source_name': 'adrenal 20wk', 'full_rpkm': 0.929066, 'exp_rpkm': 0.929, 'var': 0.01238312, 'project_desc': 'PRJNA270632', '_version_': 1785734388628062216}, 'heart 10wk': {'id': '658_Heart_10wk;_PRJNA270632', 'gene': 658, 'source_name': 'heart 10wk', 'full_rpkm': 3.19043, 'exp_rpkm': 3.19, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388628062217}, 'heart 11wk': {'id': '658_Heart_11wk;_PRJNA270632', 'gene': 658, 'source_name': 'heart 11wk', 'full_rpkm': 0.376731, 'exp_rpkm': 0.377, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388628062218}, 'heart 17wk': {'id': '658_Heart_17wk;_PRJNA270632', 'gene': 658, 'source_name': 'heart 17wk', 'full_rpkm': 0.107859, 'exp_rpkm': 0.108, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388628062219}, 'heart 18wk': {'id': '658_Heart_18wk;_PRJNA270632', 'gene': 658, 'source_name': 'heart 18wk', 'full_rpkm': 0.0935543, 'exp_rpkm': 0.0936, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388628062220}, 'heart 20wk': {'id': '658_Heart_20wk_PRJNA270632', 'gene': 658, 'source_name': 'heart 20wk', 'full_rpkm': 0.0704443, 'exp_rpkm': 0.0704, 'var': 0.000502278, 'project_desc': 'PRJNA270632', '_version_': 1785734388628062221}, 'intestine 10wk': {'id': '658_Intestine_10wk_PRJNA270632', 'gene': 658, 'source_name': 'intestine 10wk', 'full_rpkm': 1.85036, 'exp_rpkm': 1.85, 'var': 1.2477, 'project_desc': 'PRJNA270632', '_version_': 1785734388628062222}, 'intestine 11wk': {'id': '658_Intestine_11wk_PRJNA270632', 'gene': 658, 'source_name': 'intestine 11wk', 'full_rpkm': 0.65585, 'exp_rpkm': 0.656, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388628062223}, 'intestine 15wk': {'id': '658_Intestine_15wk_PRJNA270632', 'gene': 658, 'source_name': 'intestine 15wk', 'full_rpkm': 0.252999, 'exp_rpkm': 0.253, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388628062224}, 'intestine 17wk': {'id': '658_Intestine_17wk_PRJNA270632', 'gene': 658, 'source_name': 'intestine 17wk', 'full_rpkm': 0.101385, 'exp_rpkm': 0.101, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388628062225}, 'intestine 20wk': {'id': '658_Intestine_20wk_PRJNA270632', 'gene': 658, 'source_name': 'intestine 20wk', 'full_rpkm': 0.287163, 'exp_rpkm': 0.287, 'var': 0.0001074498, 'project_desc': 'PRJNA270632', '_version_': 1785734388628062226}, 'kidney 10wk': {'id': '658_Kidney_10wk_PRJNA270632', 'gene': 658, 'source_name': 'kidney 10wk', 'full_rpkm': 3.50887, 'exp_rpkm': 3.51, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388628062227}, 'kidney 16wk': {'id': '658_Kidney_16wk_PRJNA270632', 'gene': 658, 'source_name': 'kidney 16wk', 'full_rpkm': 1.41858, 'exp_rpkm': 1.42, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388628062228}, 'kidney 20wk': {'id': '658_Kidney_20wk_PRJNA270632', 'gene': 658, 'source_name': 'kidney 20wk', 'full_rpkm': 1.03199, 'exp_rpkm': 1.03, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388628062229}, 'lung 10wk': {'id': '658_Lung_10wk_PRJNA270632', 'gene': 658, 'source_name': 'lung 10wk', 'full_rpkm': 0.288491, 'exp_rpkm': 0.288, 'var': 0.00203742, 'project_desc': 'PRJNA270632', '_version_': 1785734388628062230}, 'lung 17wk': {'id': '658_Lung_17wk_PRJNA270632', 'gene': 658, 'source_name': 'lung 17wk', 'full_rpkm': 0.174586, 'exp_rpkm': 0.175, 'var': 0.0001813726, 'project_desc': 'PRJNA270632', '_version_': 1785734388628062231}, 'lung 20wk': {'id': '658_Lung_20wk_PRJNA270632', 'gene': 658, 'source_name': 'lung 20wk', 'full_rpkm': 0.158385, 'exp_rpkm': 0.158, 'var': 0.00496562, 'project_desc': 'PRJNA270632', '_version_': 1785734388628062232}, 'stomach 10wk': {'id': '658_Stomach_10wk_PRJNA270632', 'gene': 658, 'source_name': 'stomach 10wk', 'full_rpkm': 1.54698, 'exp_rpkm': 1.55, 'var': 0.052888, 'project_desc': 'PRJNA270632', '_version_': 1785734388628062233}, 'stomach 16wk': {'id': '658_Stomach_16wk_PRJNA270632', 'gene': 658, 'source_name': 'stomach 16wk', 'full_rpkm': 2.16263, 'exp_rpkm': 2.16, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388628062234}, 'stomach 18wk': {'id': '658_Stomach_18wk_PRJNA270632', 'gene': 658, 'source_name': 'stomach 18wk', 'full_rpkm': 2.25443, 'exp_rpkm': 2.25, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734388628062235}, 'stomach 20wk': {'id': '658_Stomach_20wk_PRJNA270632', 'gene': 658, 'source_name': 'stomach 20wk', 'full_rpkm': 1.87963, 'exp_rpkm': 1.88, 'var': 0.2893323, 'project_desc': 'PRJNA270632', '_version_': 1785734388628062236}};
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<div>
<select name="p" id="project-selector">
<option value="SRP051249" selected="selected" data-bioproject="PRJNA270632">
Tissue-specific circular RNA induction during human fetal development
</option>
<option value="SRP056969" data-bioproject="PRJNA280600">
RNA sequencing of total RNA from 20 human tissues
</option>
<option value="ERP003613" data-bioproject="PRJEB4337">
HPA RNA-seq normal tissues
</option>
</select>
<ul id="project-summary">
<li id="project-summary-title">Project title:
Tissue-specific circular RNA induction during human fetal development
</li>
<li id="project-summary-desc">Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA</li>
<li id="project-summary-bioprojects">BioProject: <a href="/bioproject/PRJNA270632/">PRJNA270632</a>
</li>
<li id="project-summary-pubs">Publication:
<span><a href="/pubmed/26076956/">PMID 26076956</a></span>
</li>
<li id="project-summary-analysis-date">Analysis date: Mon Apr 2 22:54:59 2018</li>
</ul>
<div id="gene-expr-details" class="expression-chart"></div>
</div>
</div>
</div>
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google.charts.load('current', {
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</div>
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<div class="rprt-section gene-bibliography">
<section class="rprt-section-header" id="bibliography"><h2 id="header-bibliography"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-bibliography .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Bibliography</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Bibliography" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
<div class="rprt-section-body" style="">
<div class="generif-pubmed">
<h3 id="relatedarticlesinpubmed">
<a href="#" class="jig-ncbitoggler-open">Related articles in PubMed</a>
</h3>
<div class="generefbl-link">
<ol class="generef-link">
<li>
<a href="/pubmed/15192043/" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=15192043">Characterization of the bone morphogenetic protein (BMP) system in human pulmonary arterial smooth muscle cells isolated from a sporadic case of primary pulmonary hypertension: roles of BMP type IB receptor (activin receptor-like kinase-6) in the mitotic action.</a>
<span class="pubmed-auth-date"> Takeda M, <em>et al</em>. Endocrinology, 2004 Sep. PMID 15192043</span>
</li>
<li>
<a href="/pubmed/21556765/" ref="ordinalpos=2&amp;ncbi_uid=658&amp;link_uid=21556765">A miR-125b binding site polymorphism in bone morphogenetic protein membrane receptor type IB gene and prostate cancer risk in China.</a>
<span class="pubmed-auth-date"> Feng N, <em>et al</em>. Mol Biol Rep, 2012 Jan. PMID 21556765</span>
</li>
<li>
<a href="/pubmed/22374147/" ref="ordinalpos=3&amp;ncbi_uid=658&amp;link_uid=22374147">Missense mutations of the BMPR1B (ALK6) gene in childhood idiopathic pulmonary arterial hypertension.</a>
<span class="pubmed-auth-date"> Chida A, <em>et al</em>. Circ J, 2012. PMID 22374147</span>
</li>
<li>
<a href="/pubmed/19738052/" ref="ordinalpos=4&amp;ncbi_uid=658&amp;link_uid=19738052">A risk variant in an miR-125b binding site in BMPR1B is associated with breast cancer pathogenesis.</a>
<span class="pubmed-auth-date"> Saetrom P, <em>et al</em>. Cancer Res, 2009 Sep 15. PMID 19738052, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC2747041/" ref="ordinalpos=0&amp;ncbi_uid=658&amp;link_uid=PMC2747041">Free PMC Article</a></span></span>
</li>
<li>
<a href="/pubmed/11781009/" ref="ordinalpos=5&amp;ncbi_uid=658&amp;link_uid=11781009">Involvement of BMP-2 signaling in a cartilage cap in osteochondroma.</a>
<span class="pubmed-auth-date"> Nakase T, <em>et al</em>. J Orthop Res, 2001 Nov. PMID 11781009</span>
</li>
</ol>
<p class="see-all-pm">
<a href="/pubmed?LinkName=gene_pubmed&amp;from_uid=658" title="See all 133 citations in Pubmed">See all (133) citations in PubMed</a>
</p>
</div>
</div>
<div class="generif-pubmed generif">
<h3 id="generifsgenereferencesintofunctions">
<a href="#" class="jig-ncbitoggler-open">GeneRIFs: Gene References Into Functions</a>
</h3>
<div>
<a href="/gene/about-generif" class="whatisthis">What's a GeneRIF?</a>
<div class="generefbl-link">
<ol class="generef-link">
<li class="gene-rif-popper">
<a href="/pubmed/35501253" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=35501253">BMPR1B Polymorphisms (rs1434536 and rs1970801) are Associated With Breast Cancer Susceptibility in Northwest Chinese Han Females: A Case-Control Study.</a>
<div id="gene-popper1" class="gene-rif-popper">Title: BMPR1B Polymorphisms (rs1434536 and rs1970801) are Associated With Breast Cancer Susceptibility in Northwest Chinese Han Females: A Case-Control Study.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/33486847" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=33486847">BMPR1B gene in brachydactyly type 2-A family with de novo R486W mutation and a disease phenotype.</a>
<div id="gene-popper2" class="gene-rif-popper">Title: BMPR1B gene in brachydactyly type 2-A family with de novo R486W mutation and a disease phenotype.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/32764110" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=32764110">BMPR1A is necessary for chondrogenesis and osteogenesis, whereas BMPR1B prevents hypertrophic differentiation.</a>
<div id="gene-popper3" class="gene-rif-popper">Title: BMPR1A is necessary for chondrogenesis and osteogenesis, whereas BMPR1B prevents hypertrophic differentiation.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/33215411" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=33215411">CDMP1 promotes type II collagen and aggrecan synthesis of nucleus pulposus cell via the mediation of ALK6.</a>
<div id="gene-popper4" class="gene-rif-popper">Title: CDMP1 promotes type II collagen and aggrecan synthesis of nucleus pulposus cell via the mediation of ALK6.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/32001529" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=32001529">The quiescent fraction of chronic myeloid leukemic stem cells depends on BMPR1B, Stat3 and BMP4-niche signals to persist in patients in remission.</a>
<div id="gene-popper5" class="gene-rif-popper">Title: The quiescent fraction of chronic myeloid leukemic stem cells depends on BMPR1B, Stat3 and BMP4-niche signals to persist in patients in remission.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/31769494" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=31769494">BMPR1A and BMPR1B Missense Mutations Cause Primary Ovarian Insufficiency.</a>
<div id="gene-popper6" class="gene-rif-popper">Title: BMPR1A and BMPR1B Missense Mutations Cause Primary Ovarian Insufficiency.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/30713213" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=30713213">identified 2 SNPs on BMPR1B showing significantly independent correlations with thicker cIMT.</a>
<div id="gene-popper7" class="gene-rif-popper">Title: Common Genetic Variants on Bone Morphogenetic Protein Receptor Type IB (BMPR1B) Gene Are Predictive for Carotid Intima-Media Thickness.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/29322508" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=29322508">A novel homozygous variant in BMPR1B underlies acromesomelic dysplasia Hunter-Thompson type in a consanguineous family of Pakistani origin</a>
<div id="gene-popper8" class="gene-rif-popper">Title: A novel homozygous variant in BMPR1B underlies acromesomelic dysplasia Hunter-Thompson type.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/29113831" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=29113831">the level of apoptosis was inversely proportional to the expression of bone morphogenetic protein (BMPR1B) and follicle stimulating hormone (FSH) receptors, in granulosa cells.</a>
<div id="gene-popper9" class="gene-rif-popper">Title: The effect of ovarian reserve and receptor signalling on granulosa cell apoptosis during human follicle development.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/29581481" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=29581481">Our findings show that also recessive complex digit malformation can be caused by BMPR1B variant and not all biallelic BMPR1B variants cause acromesomelic dysplasia. PDHA2 is a novel candidate gene for male infertility; the protein product is a mitochondrial enzyme with highest expression in ejaculated sperm.</a>
<div id="gene-popper10" class="gene-rif-popper">Title: Linked homozygous BMPR1B and PDHA2 variants in a consanguineous family with complex digit malformation and male infertility.</div>
</li>
</ol>
</div>
<div class="submit-genrif">
<span>Submit:</span>
<a href="/gene/submit-generif/?geneId=658&amp;sym=BMPR1B&amp;name=bone morphogenetic protein receptor type 1B&amp;org=Homo sapiens">New GeneRIF</a>
<a href="/RefSeq/update.cgi?geneid=658&amp;symbol=BMPR1B;task=fixpub">Correction</a>
<a href="https://www.ncbi.nlm.nih.gov/gene?db=gene&amp;report=generif&amp;term=658" class="seeall-generif">See all GeneRIFs (56)</a>
</div>
</div>
</div>
</div>
</div>
<div class="rprt-section gene-phenotypes">
<section class="rprt-section-header" id="phenotypes">
<h2 id="header-phenotypes">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-phenotypes .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Phenotypes</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Phenotype" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body info-phenotype">
<p class="nochild-link">
<a href="/gtr/tests/?term=BMPR1B[gene]">Find tests for this gene in the NIH Genetic Testing Registry (GTR)</a>
</p>
<p class="nochild-link">
<a href="/gap/PheGenI?tab=1&amp;gene=658">Review eQTL and phenotype association data in this region using PheGenI</a>
</p>
<div>
<h3 id="associatedconditions">Associated conditions</h3>
<table class="jig-ncbigrid gtr-associated-cond">
<thead>
<tr>
<th class="description">Description</th>
<th>Tests</th>
</tr>
</thead>
<tbody>
<tr>
<td>
<a href="/gtr/conditions/C4225404" ref="ncbi_uid=658&amp;link_uid=C4225404">Acromesomelic dysplasia 3</a>
<div class="gtr-associated-cond-extra">
<span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C4225404" ref="ncbi_uid=658&amp;link_uid=C4225404">C4225404</a></span>
<span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/609441" ref="ncbi_uid=658"> 609441</a></span>
<span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span>
</div>
</td>
<td>
<a href="/gtr/tests/?term=C4225404[DISCUI]&amp;condition=C4225404&amp;compare_labs=1" ref="ncbi_uid=658">Compare labs</a>
</td>
</tr>
<tr>
<td>
<a href="/gtr/conditions/C4225183" ref="ncbi_uid=658&amp;link_uid=C4225183">Brachydactyly type A1D</a>
<div class="gtr-associated-cond-extra">
<span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C4225183" ref="ncbi_uid=658&amp;link_uid=C4225183">C4225183</a></span>
<span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/616849" ref="ncbi_uid=658"> 616849</a></span>
<span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span>
</div>
</td>
<td>
<a href="/gtr/tests/?term=C4225183[DISCUI]&amp;condition=C4225183&amp;compare_labs=1" ref="ncbi_uid=658">Compare labs</a>
</td>
</tr>
<tr>
<td>
<a href="/gtr/conditions/C1832702" ref="ncbi_uid=658&amp;link_uid=C1832702">Type A2 brachydactyly</a>
<div class="gtr-associated-cond-extra">
<span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C1832702" ref="ncbi_uid=658&amp;link_uid=C1832702">C1832702</a></span>
<span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/112600" ref="ncbi_uid=658"> 112600</a></span>
<span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span>
</div>
</td>
<td>
<a href="/gtr/tests/?term=C1832702[DISCUI]&amp;condition=C1832702&amp;compare_labs=1" ref="ncbi_uid=658">Compare labs</a>
</td>
</tr>
</tbody>
</table>
</div>
<div>
<h3 id="ebigwascatalog">EBI GWAS Catalog</h3>
<table class="jig-ncbigrid gtr-associated-cond" data-jigconfig="isPageable: true, pageSize: 10">
<thead>
<tr>
<th class="description">Description</th>
</tr>
</thead>
<tbody>
<tr>
<td>A genome-wide linkage and association scan reveals novel loci for hypertension and blood pressure traits.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/22384028">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/22384028">PubMed</a></span></div></div></div></td>
</tr>
<tr>
<td>Family-based genome-wide association scan of attention-deficit/hyperactivity disorder.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/20732626">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/20732626">PubMed</a></span></div></div></div></td>
</tr>
<tr>
<td>Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/24529757">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/24529757">PubMed</a></span></div></div></div></td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<div class="rprt-section gene-variation">
<section class="rprt-section-header" id="variation">
<h2 id="header-variation">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-variation .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Variation</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.variation" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<p class="nochild-link">
<a href="/clinvar/?term=BMPR1B[gene]" ref="log$=recordlinks">See variants in ClinVar</a>
</p>
<p class="nochild-link">
<a href="/dbvar?LinkName=gene_dbvar&amp;from_uid=658" ref="log$=recordlinks">See studies and variants in dbVar</a>
</p>
<p class="nochild-link">
<a href="/variation/view/?q=658[geneid]&amp;assm=GCF_000001405.25" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh37.p13)">See Variation Viewer (GRCh37.p13)</a>
</p>
<p class="nochild-link">
<a href="/variation/view/?q=658[geneid]" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh38)">See Variation Viewer (GRCh38)</a>
</p>
<set></set>
<set></set>
</div>
</div>
<div class="rprt-section gene-HIV-1-interactions">
<section class="rprt-section-header" id="HIV-1-interactions">
<h2 id="header-HIV-1-interactions">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-HIV-1-interactions .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">HIV-1 interactions</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.HIV1_interactions" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div class="fgrid">
<h3 id="proteininteractions">Protein interactions</h3>
<table summary="protein interactions" class="jig-ncbigrid">
<thead>
<tr>
<th id="hivprotein">Protein</th>
<th id="gene-hivprotein">Gene</th>
<th id="hivinter">Interaction</th>
<th id="hivpub">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="hivprotein">
<a href="/protein/28876544">Envelope surface glycoprotein gp120</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">Treatment of pulmonary arterial smooth muscle cells with HIV-1 gp120 downregulates expression of BMPR-2, BMPR-1A, and BMPR-1B proteins</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24008158" href="/pubmed/24008158">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/28872818">Nef</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/156110">nef</a>
</td>
<td headers="hivinter">Treatment of pulmonary arterial smooth muscle cells with HIV-1 Nef downregulates expression of BMPR-2, BMPR-1A, and BMPR-1B proteins</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24008158" href="/pubmed/24008158">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/9629358">Tat</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">Treatment of pulmonary arterial smooth muscle cells with HIV-1 Tat modulates expression of BMPR-2, BMPR-1A, and BMPR-1B proteins</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24008158" href="/pubmed/24008158">PubMed</a>
</td>
</tr>
</tbody>
</table>
<p class="withnote">
<a class="note" href="/genome/viruses/retroviruses/hiv-1/interactions/">Go to the HIV-1, Human Interaction Database </a>
</p>
</div>
</div>
</div>
<div class="rprt-section gene-pathways">
<section class="rprt-section-header" id="pathways">
<h2 id="header-pathways">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-pathways .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Pathways from PubChem</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<ul class="geneinfo-subsec infopathway">
<iframe title="Pathways in which the gene target is involved" class="pubchem-widget" scrolling="no" src="https://pubchem.ncbi.nlm.nih.gov/gene/658#section=Pathways&amp;embed=true&amp;hide_all_headings=true&amp;page_size=25" style="border: 0; width: 100%;"></iframe>
<script type="text/javascript" src="https://pubchem.ncbi.nlm.nih.gov/pcfe/libs/iframeResizer.min.js"></script>
<script type="text/javascript">iFrameResize({log: false, checkOrigin: false}, '.pubchem-widget')</script>
</ul>
</div>
</div>
<div class="rprt-section gene-interactions">
<section class="rprt-section-header" id="interactions">
<h2 id="header-interactions">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-interactions .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Interactions</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Interactions" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<table summary="Gene Interaction" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/658/data/interaction/',webserviceParams: 'p$l=Ajax&amp;p$debugoutput=off', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
<thead>
<tr>
<th id="inter-prod">Products</th>
<th id="inter-interactant">Interactant</th>
<th id="inter-otherGene">Other Gene</th>
<th id="inter-compl">Complex</th>
<th id="inter-source">Source</th>
<th id="inter-pubs">Pubs</th>
<th id="inter-desc">Description</th>
</tr>
</thead>
<tbody></tbody>
</table>
</div>
</div>
<div class="rprt-section gene-general-gene-info">
<section class="rprt-section-header" id="general-gene-info">
<h2 id="header-general-gene-info">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-gene-info .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">General gene information</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.General_Gene_Information" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body" style="">
<div id="gene-markers">
<h3 id="markers">
<a class="jig-ncbitoggler">Markers</a>
</h3>
<div>
<ul class="marker odd">
<li class="marker">RH123060 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=135453%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=135453">UniSTS:135453</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">D4S2380 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=9528%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=9528">UniSTS:9528</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">G62599 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=139579%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=139579">UniSTS:139579</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">MARC_8975-8976:1025019065:3 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=531260%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=531260">UniSTS:531260</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">SHGC-51110 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=19520%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=19520">UniSTS:19520</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">SHGC-24790 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=57665%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=57665">UniSTS:57665</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">G41993 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=29509%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=29509">UniSTS:29509</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">SHGC-79355 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=103254%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=103254">UniSTS:103254</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">SHGC-51118 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=55907%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=55907">UniSTS:55907</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">SHGC-51758 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=64611%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=64611">UniSTS:64611</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">D4S1045 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=21131%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=21131">UniSTS:21131</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">RH70713 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=41869%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=41869">UniSTS:41869</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">SHGC-67739 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=4761%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=4761">UniSTS:4761</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">SHGC-78087 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=102045%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=102045">UniSTS:102045</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">SHGC-9264 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=10969%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=10969">UniSTS:10969</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">SHGC4-1504 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=35054%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=35054">UniSTS:35054</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">SHGC-59827 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=56818%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=56818">UniSTS:56818</a></li></ul></li>
</ul>
</div>
</div>
<div></div>
<div class="infosec">
<h3 id="homology">
<a class="jig-ncbitoggler-open">Homology</a>
</h3>
<ul class="geneinfo-subsec">
<li>
<a href="/gene/658/ortholog/" id="ncbi-ortholog-link">NCBI Orthologs</a>
</li>
<a href="https://www.orthodb.org/?ncbi=658" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8178" target="_blank">
Orthologs from OrthoDB
</a>
</ul>
</div>
<!--<component id="Gene_InfoPathway"/>-->
<div class="gene-ontology infosec">
<h3 id="gene-ontology">
<a class="jig-ncbitoggler-open">
<span>Gene Ontology</span>
</a>
<a target="_blank" href="http://www.ebi.ac.uk/GOA" class="g-ontology-src" title="Provided by GOA">Provided by GOA</a>
</h3>
<div class="ontology-tables">
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Function</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005524">enables ATP binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-1-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/12065756" target="_blank" title="PubMed ID 12065756" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=12065756">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0036122">enables BMP binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-2-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/18184661" target="_blank" title="PubMed ID 18184661" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=18184661">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0098821">enables BMP receptor activity</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-3-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/12065756" target="_blank" title="PubMed ID 12065756" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=12065756">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0046332">enables SMAD binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-4-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/12065756" target="_blank" title="PubMed ID 12065756" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=12065756">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0016361">enables activin receptor activity, type I</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-5-0" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0016362">enables activin receptor activity, type II</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-6-0" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0046872">enables metal ion binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-7-0" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005515">enables protein binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-8-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/10854429,11266516,11279102,11549681,16127465,19229295,21791611,21976273,24098149,24904118,33308444" target="_blank" title="PubMed ID 10854429,11266516,11279102,11549681,16127465,19229295,21791611,21976273,24098149,24904118,33308444" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=10854429,11266516,11279102,11549681,16127465,19229295,21791611,21976273,24098149,24904118,33308444">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0004674">enables protein serine/threonine kinase activity</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-9-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/12065756" target="_blank" title="PubMed ID 12065756" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=12065756">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005025">enables transforming growth factor beta receptor activity, type I</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-10-0" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005026">enables transforming growth factor beta receptor activity, type II</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-11-0" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0070123">enables transforming growth factor beta receptor activity, type III</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-12-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-12-0" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0004675">enables transmembrane receptor protein serine/threonine kinase activity</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-13-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> NAS</a>
<div id="evidence-code-13-0" class="ecode">Non-traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/10051328" target="_blank" title="PubMed ID 10051328" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=10051328">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0004888">enables transmembrane signaling receptor activity</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-14-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-14-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/18184661" target="_blank" title="PubMed ID 18184661" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=18184661">PubMed</a> </td>
</tr>
</tbody>
</table>
</div>
</div>
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Process</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0030509">involved_in BMP signaling pathway</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-1-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0030509">involved_in BMP signaling pathway</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-2-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/12065756,18184661,18436533" target="_blank" title="PubMed ID 12065756,18184661,18436533" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=12065756,18184661,18436533">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0030509">involved_in BMP signaling pathway</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> NAS</a>
<div id="evidence-code-3-1" class="ecode">Non-traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/10051328" target="_blank" title="PubMed ID 10051328" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=10051328">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0032924">involved_in activin receptor signaling pathway</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-4-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0001502">involved_in cartilage condensation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-5-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0030154">involved_in cell differentiation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-6-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0071773">involved_in cellular response to BMP stimulus</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-7-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/18326817" target="_blank" title="PubMed ID 18326817" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=18326817">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0071363">involved_in cellular response to growth factor stimulus</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-8-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0021953">involved_in central nervous system neuron differentiation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-9-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0002063">involved_in chondrocyte development</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-10-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0009953">involved_in dorsal/ventral pattern formation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-11-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0060350">involved_in endochondral bone morphogenesis</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-12-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-12-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0001654">involved_in eye development</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-13-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-13-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0006954">involved_in inflammatory response</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-14-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-14-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:1902731">involved_in negative regulation of chondrocyte proliferation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-15-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-15-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0001649">involved_in osteoblast differentiation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-16-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-16-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/28214897" target="_blank" title="PubMed ID 28214897" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=28214897">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0001550">involved_in ovarian cumulus expansion</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-17-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-17-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0042698">involved_in ovulation cycle</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-18-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-18-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0030501">involved_in positive regulation of bone mineralization</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-19-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-19-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/18436533" target="_blank" title="PubMed ID 18436533" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=18436533">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0061036">involved_in positive regulation of cartilage development</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-20-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-20-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0032332">involved_in positive regulation of chondrocyte differentiation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-21-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-21-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:1902043">involved_in positive regulation of extrinsic apoptotic signaling pathway via death domain receptors</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-22-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-22-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0010628">acts_upstream_of positive regulation of gene expression</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-23-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-23-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/28214897" target="_blank" title="PubMed ID 28214897" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=28214897">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0045669">involved_in positive regulation of osteoblast differentiation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-24-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-24-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/18436533" target="_blank" title="PubMed ID 18436533" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=18436533">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0045944">involved_in positive regulation of transcription by RNA polymerase II</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-25-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-25-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/18326817" target="_blank" title="PubMed ID 18326817" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=18326817">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0030166">involved_in proteoglycan biosynthetic process</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-26-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-26-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0060041">involved_in retina development in camera-type eye</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-27-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-27-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0031290">involved_in retinal ganglion cell axon guidance</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-28-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-28-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
</tbody>
</table>
</div>
</div>
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-config="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Component</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:1990712">part_of HFE-transferrin receptor complex</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IC</a>
<div id="evidence-code-1-2" class="ecode">Inferred by Curator<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/24904118" target="_blank" title="PubMed ID 24904118" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=24904118">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0030425">located_in dendrite</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-2-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0043025">located_in neuronal cell body</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-3-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005886">is_active_in plasma membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-4-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005886">located_in plasma membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-5-2" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005886">located_in plasma membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-6-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0043235">part_of receptor complex</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-7-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0043235">part_of receptor complex</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-8-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/14523231" target="_blank" title="PubMed ID 14523231" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=14523231">PubMed</a> </td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
</div>
</div>
</div>
<div class="rprt-section gene-general-protein-info">
<section class="rprt-section-header" id="general-protein-info">
<h2 id="header-general-protein-info">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-protein-info .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">General protein information</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.General_Protein_Information" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<dl>
<dt>Preferred Names</dt>
<dd>bone morphogenetic protein receptor type-1B</dd>
</dl>
<dl>
<dt>Names</dt>
<dd>BMP type-1B receptor</dd>
<dd>BMPR-1B</dd>
<dd>activin receptor-like kinase 6</dd>
<dd>bone morphogenetic protein receptor, type IB</dd>
<dd>serine/threonine receptor kinase</dd>
</dl>
<dl>
<dt class="heading">NP_001194.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/2.7.11.30">2.7.11.30</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">NP_001243721.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/2.7.11.30">2.7.11.30</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">NP_001243722.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/2.7.11.30">2.7.11.30</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">NP_001243723.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/2.7.11.30">2.7.11.30</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_011530503.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/2.7.11.30">2.7.11.30</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_016864047.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/2.7.11.30">2.7.11.30</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_016864048.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/2.7.11.30">2.7.11.30</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_016864049.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/2.7.11.30">2.7.11.30</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_047272047.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/2.7.11.30">2.7.11.30</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_047272049.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/2.7.11.30">2.7.11.30</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_047272050.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/2.7.11.30">2.7.11.30</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_047272051.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/2.7.11.30">2.7.11.30</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054206712.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/2.7.11.30">2.7.11.30</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054206713.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/2.7.11.30">2.7.11.30</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054206714.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/2.7.11.30">2.7.11.30</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054206715.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/2.7.11.30">2.7.11.30</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054206716.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/2.7.11.30">2.7.11.30</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054206717.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/2.7.11.30">2.7.11.30</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054206718.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/2.7.11.30">2.7.11.30</a></li>
</ul>
</dd>
</dl>
</div>
</div>
<div class="rprt-section gene-reference-sequences">
<section class="rprt-section-header" id="reference-sequences">
<h2 id="header-reference-sequences">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-reference-sequences .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">NCBI Reference Sequences (RefSeq)</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.NCBI_Reference_Sequences_RefS" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<p>
<span class="new-icon">NEW</span>
<strong>Try the new <a href="/datasets/tables/genes/?table_type=transcripts&amp;ids=658&amp;utm_source=gene&amp;utm_medium=referral&amp;utm_campaign=refseq" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report." data-ga-category="refseq" data-ga-action="click_datasets_link" data-ga-label="transcript_table">Transcript table</a></strong>
</p>
<h3 class="genomerefseqs gene_std_toggler" id="refseqset-independent">
<a class="jig-ncbitoggler-open">RefSeqs maintained independently of Annotated
Genomes</a>
</h3>
<div class="genomerefseqs_slave">
<p class="desc"> These reference sequences exist independently of genome builds. <a href="#refseq-expl" id="expl-refseg">Explain</a></p>
<p id="refseq-expl"> These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in <a href="#geneGenomic regions, transcripts, and products">Genomic regions,
transcripts, and products</a> above. </p>
<h4 id="genomic-p56957696">Genomic </h4>
<ol>
<li>
<p>NG_009245.1 RefSeqGene</p>
<dl>
<dt>Range</dt>
<dd class="rs-range">
<span>4979..405472</span>
</dd>
<dt>Download</dt>
<dd><a href="/nuccore/NG_009245.1?from=4979&amp;to=405472&amp;report=genbank" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=NG_009245.1?from=4979&amp;to=405472&amp;report=genbank">GenBank</a>, <a href="/nuccore/NG_009245.1?from=4979&amp;to=405472&amp;report=fasta" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=NG_009245.1?from=4979&amp;to=405472&amp;report=fasta">FASTA</a>, <a href="/nuccore/NG_009245.1?from=1&amp;to=465545&amp;report=graph&amp;content=5" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=NG_009245.1?from=1&amp;to=465545&amp;report=graph&amp;content=5">Sequence Viewer (Graphics)</a></dd>
</dl>
</li>
</ol>
<h4 id="mrnaandproteins-p106561088">mRNA and Protein(s) </h4>
<ol>
<li>
<p><a href="/nuccore/NM_001203.3">NM_001203.3</a><a href="/protein/NP_001194.1">NP_001194.1</a>  bone morphogenetic protein receptor type-1B isoform b precursor</p>
<p>
<a href="/ipg/NP_001194.1/" ref="ncbi_uid=658">See identical proteins and their annotated locations for NP_001194.1</a>
</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Description</dt>
<dd>Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode isoform b.</dd>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AC093634, AC105395, AW299723, BC069796">AC093634, AC105395, AW299723, BC069796</a>
</dd>
<dt>Consensus CDS</dt>
<dd>
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&amp;GO=MainBrowse&amp;DATA=CCDS3642.1">CCDS3642.1</a>
</dd>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B2R953" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B2R953</a>, <a href="https://www.uniprot.org/uniprot/B4DSV1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B4DSV1</a>, <a href="https://www.uniprot.org/uniprot/O00238" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">O00238</a>, <a href="https://www.uniprot.org/uniprot/P78366" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">P78366</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/A8KAE3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">A8KAE3</a>
</dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000426617.1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">ENSP00000426617.1</a>, <a href="http://www.ensembl.org/id/ENST00000515059.6" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">ENST00000515059.6</a></dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001194.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=271121">cd14219</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">198</span><span class="cddto">502</span></dt>
<dd class="clearfix"> STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=395845">pfam01064</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">34</span><span class="cddto">106</span></dt>
<dd class="clearfix"> Activin_recp; Activin types I and II receptor domain</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/NM_001256792.2">NM_001256792.2</a><a href="/protein/NP_001243721.1">NP_001243721.1</a>  bone morphogenetic protein receptor type-1B isoform b precursor</p>
<p>
<a href="/ipg/NP_001243721.1/" ref="ncbi_uid=658">See identical proteins and their annotated locations for NP_001243721.1</a>
</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Description</dt>
<dd>Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode isoform b.</dd>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AC092609, AC105395, AK313642">AC092609, AC105395, AK313642</a>
</dd>
<dt>Consensus CDS</dt>
<dd>
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&amp;GO=MainBrowse&amp;DATA=CCDS3642.1">CCDS3642.1</a>
</dd>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B2R953" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B2R953</a>, <a href="https://www.uniprot.org/uniprot/B4DSV1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B4DSV1</a>, <a href="https://www.uniprot.org/uniprot/O00238" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">O00238</a>, <a href="https://www.uniprot.org/uniprot/P78366" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">P78366</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/A8KAE3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">A8KAE3</a>
</dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000425444.1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">ENSP00000425444.1</a>, <a href="http://www.ensembl.org/id/ENST00000512312.5" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">ENST00000512312.5</a></dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001243721.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=271121">cd14219</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">198</span><span class="cddto">502</span></dt>
<dd class="clearfix"> STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=395845">pfam01064</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">34</span><span class="cddto">106</span></dt>
<dd class="clearfix"> Activin_recp; Activin types I and II receptor domain</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/NM_001256793.2">NM_001256793.2</a><a href="/protein/NP_001243722.1">NP_001243722.1</a>  bone morphogenetic protein receptor type-1B isoform a precursor</p>
<p>
<a href="/ipg/NP_001243722.1/" ref="ncbi_uid=658">See identical proteins and their annotated locations for NP_001243722.1</a>
</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Description</dt>
<dd>Transcript Variant: This variant (1) encodes the longer isoform (a).</dd>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AC092609, AC105395, AK299930">AC092609, AC105395, AK299930</a>
</dd>
<dt>Consensus CDS</dt>
<dd>
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&amp;GO=MainBrowse&amp;DATA=CCDS58919.1">CCDS58919.1</a>
</dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/A8KAE3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">A8KAE3</a>
</dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000401907.2" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">ENSP00000401907.2</a>, <a href="http://www.ensembl.org/id/ENST00000440890.7" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">ENST00000440890.7</a></dd>
<dt class="clear"> Conserved Domains (3) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001243722.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=214567">smart00220</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">235</span><span class="cddto">519</span></dt>
<dd class="clearfix"> S_TKc; Serine/Threonine protein kinases, catalytic domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=271121">cd14219</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">228</span><span class="cddto">532</span></dt>
<dd class="clearfix"> STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279413">pfam01064</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">60</span><span class="cddto">140</span></dt>
<dd class="clearfix"> Activin_recp; Activin types I and II receptor domain</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/NM_001256794.1">NM_001256794.1</a><a href="/protein/NP_001243723.1">NP_001243723.1</a>  bone morphogenetic protein receptor type-1B isoform b precursor</p>
<p>
<a href="/ipg/NP_001243723.1/" ref="ncbi_uid=658">See identical proteins and their annotated locations for NP_001243723.1</a>
</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Description</dt>
<dd>Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode isoform b.</dd>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AC105395, AK293008, AK299930">AC105395, AK293008, AK299930</a>
</dd>
<dt>Consensus CDS</dt>
<dd>
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&amp;GO=MainBrowse&amp;DATA=CCDS3642.1">CCDS3642.1</a>
</dd>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B2R953" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B2R953</a>, <a href="https://www.uniprot.org/uniprot/B4DSV1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B4DSV1</a>, <a href="https://www.uniprot.org/uniprot/O00238" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">O00238</a>, <a href="https://www.uniprot.org/uniprot/P78366" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">P78366</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/A8KAE3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">A8KAE3</a>
</dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000264568.4" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">ENSP00000264568.4</a>, <a href="http://www.ensembl.org/id/ENST00000264568.8" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">ENST00000264568.8</a></dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001243723.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=271121">cd14219</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">198</span><span class="cddto">502</span></dt>
<dd class="clearfix"> STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=395845">pfam01064</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">34</span><span class="cddto">106</span></dt>
<dd class="clearfix"> Activin_recp; Activin types I and II receptor domain</dd>
</dl>
</dd>
</dl>
</li>
</ol>
</div>
<h3 class="genomerefseqs gene_std_toggler" id="annotatedrefseq-title">
<a class="jig-ncbitoggler-open">RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08</a>
</h3>
<div class="genomerefseqs_slave">
<p class="desc"> The following sections contain reference sequences that belong to a
specific genome build. <a href="#" id="expl-genomes">Explain</a></p>
<p id="expl-genomes-desc" style="display:none">This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.</p>
<h3 id="refseq-sequencedescription-p61989840">Reference GRCh38.p14 Primary Assembly</h3>
<h4 id="genomic-p61989840">Genomic </h4>
<ol>
<li>
<p>NC_000004.12 Reference GRCh38.p14 Primary Assembly</p>
<dl>
<dt>Range</dt>
<dd class="rs-range">
<span>94757955..95158450</span>
</dd>
<dt>Download</dt>
<dd><a href="/nuccore/NC_000004.12?from=94757955&amp;to=95158450&amp;report=genbank" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=NC_000004.12?from=94757955&amp;to=95158450&amp;report=genbank">GenBank</a>, <a href="/nuccore/NC_000004.12?from=94757955&amp;to=95158450&amp;report=fasta" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=NC_000004.12?from=94757955&amp;to=95158450&amp;report=fasta">FASTA</a>, <a href="/nuccore/NC_000004.12?from=94697880&amp;to=95218523&amp;report=graph&amp;content=5" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=NC_000004.12?from=94697880&amp;to=95218523&amp;report=graph&amp;content=5">Sequence Viewer (Graphics)</a></dd>
</dl>
</li>
</ol>
<h4 id="mrnaandproteins-p110462896">mRNA and Protein(s) </h4>
<ol>
<li>
<p><a href="/nuccore/XM_017008559.2">XM_017008559.2</a><a href="/protein/XP_016864048.1">XP_016864048.1</a>  bone morphogenetic protein receptor type-1B isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B2R953" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B2R953</a>, <a href="https://www.uniprot.org/uniprot/B4DSV1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B4DSV1</a>, <a href="https://www.uniprot.org/uniprot/O00238" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">O00238</a>, <a href="https://www.uniprot.org/uniprot/P78366" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">P78366</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/A8KAE3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">A8KAE3</a>
</dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_016864048.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=271121">cd14219</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">198</span><span class="cddto">502</span></dt>
<dd class="clearfix"> STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=395845">pfam01064</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">34</span><span class="cddto">106</span></dt>
<dd class="clearfix"> Activin_recp; Activin types I and II receptor domain</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047416093.1">XM_047416093.1</a><a href="/protein/XP_047272049.1">XP_047272049.1</a>  bone morphogenetic protein receptor type-1B isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B2R953" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B2R953</a>, <a href="https://www.uniprot.org/uniprot/B4DSV1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B4DSV1</a>, <a href="https://www.uniprot.org/uniprot/O00238" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">O00238</a>, <a href="https://www.uniprot.org/uniprot/P78366" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">P78366</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/A8KAE3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">A8KAE3</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047416091.1">XM_047416091.1</a><a href="/protein/XP_047272047.1">XP_047272047.1</a>  bone morphogenetic protein receptor type-1B isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B2R953" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B2R953</a>, <a href="https://www.uniprot.org/uniprot/B4DSV1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B4DSV1</a>, <a href="https://www.uniprot.org/uniprot/O00238" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">O00238</a>, <a href="https://www.uniprot.org/uniprot/P78366" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">P78366</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/A8KAE3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">A8KAE3</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_011532201.3">XM_011532201.3</a><a href="/protein/XP_011530503.1">XP_011530503.1</a>  bone morphogenetic protein receptor type-1B isoform X1</p>
<p>
<a href="/ipg/XP_011530503.1/" ref="ncbi_uid=658">See identical proteins and their annotated locations for XP_011530503.1</a>
</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B2R953" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B2R953</a>, <a href="https://www.uniprot.org/uniprot/B4DSV1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B4DSV1</a>, <a href="https://www.uniprot.org/uniprot/O00238" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">O00238</a>, <a href="https://www.uniprot.org/uniprot/P78366" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">P78366</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/A8KAE3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">A8KAE3</a>
</dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_011530503.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=271121">cd14219</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">198</span><span class="cddto">502</span></dt>
<dd class="clearfix"> STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=395845">pfam01064</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">34</span><span class="cddto">106</span></dt>
<dd class="clearfix"> Activin_recp; Activin types I and II receptor domain</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_017008558.2">XM_017008558.2</a><a href="/protein/XP_016864047.1">XP_016864047.1</a>  bone morphogenetic protein receptor type-1B isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B2R953" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B2R953</a>, <a href="https://www.uniprot.org/uniprot/B4DSV1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B4DSV1</a>, <a href="https://www.uniprot.org/uniprot/O00238" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">O00238</a>, <a href="https://www.uniprot.org/uniprot/P78366" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">P78366</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/A8KAE3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">A8KAE3</a>
</dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_016864047.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=271121">cd14219</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">198</span><span class="cddto">502</span></dt>
<dd class="clearfix"> STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=395845">pfam01064</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">34</span><span class="cddto">106</span></dt>
<dd class="clearfix"> Activin_recp; Activin types I and II receptor domain</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047416094.1">XM_047416094.1</a><a href="/protein/XP_047272050.1">XP_047272050.1</a>  bone morphogenetic protein receptor type-1B isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B2R953" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B2R953</a>, <a href="https://www.uniprot.org/uniprot/B4DSV1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B4DSV1</a>, <a href="https://www.uniprot.org/uniprot/O00238" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">O00238</a>, <a href="https://www.uniprot.org/uniprot/P78366" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">P78366</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/A8KAE3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">A8KAE3</a>
</dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000500035.1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">ENSP00000500035.1</a>, <a href="http://www.ensembl.org/id/ENST00000672698.1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">ENST00000672698.1</a></dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_017008560.2">XM_017008560.2</a><a href="/protein/XP_016864049.1">XP_016864049.1</a>  bone morphogenetic protein receptor type-1B isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B2R953" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B2R953</a>, <a href="https://www.uniprot.org/uniprot/B4DSV1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B4DSV1</a>, <a href="https://www.uniprot.org/uniprot/O00238" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">O00238</a>, <a href="https://www.uniprot.org/uniprot/P78366" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">P78366</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/A8KAE3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">A8KAE3</a>
</dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000421671.1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">ENSP00000421671.1</a>, <a href="http://www.ensembl.org/id/ENST00000509540.6" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">ENST00000509540.6</a></dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_016864049.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=271121">cd14219</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">198</span><span class="cddto">502</span></dt>
<dd class="clearfix"> STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=395845">pfam01064</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">34</span><span class="cddto">106</span></dt>
<dd class="clearfix"> Activin_recp; Activin types I and II receptor domain</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047416095.1">XM_047416095.1</a><a href="/protein/XP_047272051.1">XP_047272051.1</a>  bone morphogenetic protein receptor type-1B isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B2R953" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B2R953</a>, <a href="https://www.uniprot.org/uniprot/B4DSV1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B4DSV1</a>, <a href="https://www.uniprot.org/uniprot/O00238" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">O00238</a>, <a href="https://www.uniprot.org/uniprot/P78366" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">P78366</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/A8KAE3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">A8KAE3</a>
</dd>
</dl>
</li>
</ol>
<h3 id="refseq-sequencedescription-p46056064">Alternate T2T-CHM13v2.0</h3>
<h4 id="genomic-p46056064">Genomic </h4>
<ol>
<li>
<p>NC_060928.1 Alternate T2T-CHM13v2.0</p>
<dl>
<dt>Range</dt>
<dd class="rs-range">
<span>98073083..98473123</span>
</dd>
<dt>Download</dt>
<dd><a href="/nuccore/NC_060928.1?from=98073083&amp;to=98473123&amp;report=genbank" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=NC_060928.1?from=98073083&amp;to=98473123&amp;report=genbank">GenBank</a>, <a href="/nuccore/NC_060928.1?from=98073083&amp;to=98473123&amp;report=fasta" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=NC_060928.1?from=98073083&amp;to=98473123&amp;report=fasta">FASTA</a>, <a href="/nuccore/NC_060928.1?from=98013076&amp;to=98533128&amp;report=graph&amp;content=5" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=NC_060928.1?from=98013076&amp;to=98533128&amp;report=graph&amp;content=5">Sequence Viewer (Graphics)</a></dd>
</dl>
</li>
</ol>
<h4 id="mrnaandproteins-p39427024">mRNA and Protein(s) </h4>
<ol>
<li>
<p><a href="/nuccore/XM_054350739.1">XM_054350739.1</a><a href="/protein/XP_054206714.1">XP_054206714.1</a>  bone morphogenetic protein receptor type-1B isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B2R953" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B2R953</a>, <a href="https://www.uniprot.org/uniprot/B4DSV1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B4DSV1</a>, <a href="https://www.uniprot.org/uniprot/O00238" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">O00238</a>, <a href="https://www.uniprot.org/uniprot/P78366" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">P78366</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/A8KAE3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">A8KAE3</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054350741.1">XM_054350741.1</a><a href="/protein/XP_054206716.1">XP_054206716.1</a>  bone morphogenetic protein receptor type-1B isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B2R953" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B2R953</a>, <a href="https://www.uniprot.org/uniprot/B4DSV1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B4DSV1</a>, <a href="https://www.uniprot.org/uniprot/O00238" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">O00238</a>, <a href="https://www.uniprot.org/uniprot/P78366" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">P78366</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/A8KAE3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">A8KAE3</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054350737.1">XM_054350737.1</a><a href="/protein/XP_054206712.1">XP_054206712.1</a>  bone morphogenetic protein receptor type-1B isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B2R953" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B2R953</a>, <a href="https://www.uniprot.org/uniprot/B4DSV1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B4DSV1</a>, <a href="https://www.uniprot.org/uniprot/O00238" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">O00238</a>, <a href="https://www.uniprot.org/uniprot/P78366" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">P78366</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/A8KAE3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">A8KAE3</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054350742.1">XM_054350742.1</a><a href="/protein/XP_054206717.1">XP_054206717.1</a>  bone morphogenetic protein receptor type-1B isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B2R953" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B2R953</a>, <a href="https://www.uniprot.org/uniprot/B4DSV1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B4DSV1</a>, <a href="https://www.uniprot.org/uniprot/O00238" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">O00238</a>, <a href="https://www.uniprot.org/uniprot/P78366" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">P78366</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/A8KAE3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">A8KAE3</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054350738.1">XM_054350738.1</a><a href="/protein/XP_054206713.1">XP_054206713.1</a>  bone morphogenetic protein receptor type-1B isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B2R953" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B2R953</a>, <a href="https://www.uniprot.org/uniprot/B4DSV1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B4DSV1</a>, <a href="https://www.uniprot.org/uniprot/O00238" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">O00238</a>, <a href="https://www.uniprot.org/uniprot/P78366" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">P78366</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/A8KAE3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">A8KAE3</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054350740.1">XM_054350740.1</a><a href="/protein/XP_054206715.1">XP_054206715.1</a>  bone morphogenetic protein receptor type-1B isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B2R953" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B2R953</a>, <a href="https://www.uniprot.org/uniprot/B4DSV1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B4DSV1</a>, <a href="https://www.uniprot.org/uniprot/O00238" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">O00238</a>, <a href="https://www.uniprot.org/uniprot/P78366" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">P78366</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/A8KAE3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">A8KAE3</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054350743.1">XM_054350743.1</a><a href="/protein/XP_054206718.1">XP_054206718.1</a>  bone morphogenetic protein receptor type-1B isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B2R953" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B2R953</a>, <a href="https://www.uniprot.org/uniprot/B4DSV1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">B4DSV1</a>, <a href="https://www.uniprot.org/uniprot/O00238" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">O00238</a>, <a href="https://www.uniprot.org/uniprot/P78366" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">P78366</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/A8KAE3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=658&amp;nlmid=&amp;db=gene">A8KAE3</a>
</dd>
</dl>
</li>
</ol>
</div>
</div>
</div>
<div class="rprt-section gene-related-sequences">
<section class="rprt-section-header" id="related-sequences">
<h2 id="header-related-sequences">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-related-sequences .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Related sequences</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Related_Sequences" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<table id="proteinTblId" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/658/data/related-sequences/',webserviceParams: 'p$l=Ajax', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
<thead>
<tr>
<th colspan="2" id="rs-nucleo">Nucleotide</th>
<th rowspan="2" id="rs-protein">Protein</th>
</tr>
<tr>
<th id="rs-heading">Heading</th>
<th id="rs-heading-acc">Accession and Version</th>
</tr>
</thead>
<tbody></tbody>
</table>
<table id="proteinTblId" class="jig-ncbigrid" data-jigconfig="isPageable:true, pageSize:25">
<thead>
<tr>
<th class="proteinTblTh" rowspan="2" id="rs-prot-acc">Protein Accession</th>
<th class="proteinTblTh" colspan="2" id="rs-link">Links</th>
</tr>
<tr>
<th id="rs-genepept">GenPept Link</th>
<th id="rs-uniprot">UniProtKB Link</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="rs-prot-acc">O00238.1</td>
<td headers="rs-link rs-genepept">
<a href="/protein/6226778" ref="ordinalpos=1&amp;ncbi_uid=658&amp;link_uid=6226778">GenPept</a>
</td>
<td>
<a href="https://www.uniprot.org/uniprot/O00238">UniProtKB/Swiss-Prot:O00238</a>
</td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<div class="rprt-section gene-additional-links">
<section class="rprt-section-header" id="additional-links"><h2 id="header-additional-links"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-additional-links .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Additional links</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Additional_Links" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
<div class="rprt-section-body" style="">
<div id="lsdb"><h3 class="withnote" id="locusspecificdatabases"><a class="jig-ncbitoggler-open">Locus-specific Databases</a></h3><div><ul class="locusdb"><li><a href="http://databases.lovd.nl/shared/genes/BMPR1B" ref="from_uid=658" class="lsdblink">BMPR1B database</a></li></ul></div></div>
<h3 class="withnote" id="genelinkout">
<a class="jig-ncbitoggler">Gene LinkOut</a>
</h3><div>
<p>The following <a href="https://www.ncbi.nlm.nih.gov/projects/linkout/index.html">LinkOut</a> resources are supplied by external providers. These providers are responsible for maintaining the links. </p>
<div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Chemical Information</span>
</a>
<ul>
<li><span class="free-rsc"></span>Interologous Interaction Database</li>
<ul>
<li>
<a target="_blank" href="http://ophid.utoronto.ca/redirect/ncbi/human?proteins=658" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7911">
<span>Interologous Interaction Database</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>MilliporeSigma</li>
<ul>
<li>
<a target="_blank" href="https://www.sigmaaldrich.com/catalog/genes/BMPR1B?lang=en&amp;region=US" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9978">
<span>Bmpr1b products</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Molecular Biology Databases</span>
</a>
<ul>
<li><span class="free-rsc"></span>Bgee database</li>
<ul>
<li>
<a target="_blank" href="https://www.bgee.org/gene/ENSG00000138696" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10418">
<span>BMPR1B gene expression</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>BioGPS</li>
<ul>
<li>
<a target="_blank" href="http://biogps.org/gene/658/" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5059">
<span>BioGPS</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>BioGRID Open Repository of CRISPR Screens (ORCS)</li>
<ul>
<li>
<a target="_blank" href="https://orcs.thebiogrid.org/Gene/658" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10164">
<span>BioGRID CRISPR Screen Phenotypes (19 hits/1388 screens)</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Domain Mapping of Disease Mutations</li>
<ul>
<li>
<a target="_blank" href="http://bioinf.umbc.edu/DMDM/gene_prot_page.php?id=658" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7642">
<span>BMPR1B</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Eukaryotic Promoter Database</li>
<ul>
<li>
<a target="_blank" href="http://epd.vital-it.ch/cgi-bin/get_doc?db=hgEpdNew&amp;format=genome&amp;entry=BMPR1B_1" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9624">
<span>BMPR1B_1</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>GlyGen glycoinformatics resource</li>
<ul>
<li>
<a target="_blank" href="https://glygen.org/protein/O00238" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10227">
<span>GlyGen glycoinformatics resource</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Guide to Pharmacology</li>
<ul>
<li>
<a target="_blank" href="https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1789" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8191">
<span>bone morphogenetic protein receptor type IB gene</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span><span class="regis-rsc"></span>Human Gene Mutation Database</li>
<ul>
<li>
<a target="_blank" href="http://www.hgmd.cf.ac.uk/ac/gene.php?gene=BMPR1B" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=3100">
<span>Human Gene Mutation Database</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Human eFP Browser</li>
<ul>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Skeletal_Immune_Digestive&amp;modeInput=Absolute&amp;primaryGene=658" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Nervous&amp;modeInput=Absolute&amp;primaryGene=658" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Circulatory_Respiratory&amp;modeInput=Absolute&amp;primaryGene=658" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
</ul>
<li>Ingenuity Pathways Analysis</li>
<ul>
<li>
<a target="_blank" href="http://partnersolution.ingenuity.com/?cid=97ae3f91eab87a&amp;p1=Entrez&amp;p2=GV&amp;s=&amp;ipaUri=%2Fpa%2Fapi%2Fv2%2Fgeneview%3Fapplicationname%3DEntrez%26geneId%3D658%26geneidtype%3Dentrezgene" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5628">
<span>Ingenuity Pathways Analysis</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>InnateDB</li>
<ul>
<li>
<a target="_blank" href="http://www.innatedb.com/getGeneCard.do?id=30667" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7894">
<span>InnateDB</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>InterMine</li>
<ul>
<li>
<a target="_blank" href="https://www.humanmine.org/humanmine/search?keyword=ENSG00000138696" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9169">
<span>InterMine</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Kyoto Encyclopedia of Genes and Genomes</li>
<ul>
<li>
<a target="_blank" href="http://www.genome.jp/dbget-bin/www_bget?hsa:658" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5174">
<span>Kyoto Encyclopedia of Genes and Genomes</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>OMA Browser: Orthologous MAtrix</li>
<ul>
<li>
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN76622/" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9822">
<span>OMA Browser: Orthologous MAtrix</span>
</a>
</li>
<li>
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN76626/" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9822">
<span>OMA Browser: Orthologous MAtrix</span>
</a>
</li>
<li>
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN76625/" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9822">
<span>OMA Browser: Orthologous MAtrix</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>OrthoDB catalog of orthologs</li>
<ul>
<li>
<a target="_blank" href="https://www.orthodb.org/?ncbi=658" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8178">
<span>Orthologs</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>PhosphoSitePlus</li>
<ul>
<li>
<a target="_blank" href="https://www.phosphosite.org/entrezGeneIdAction.action?id=658" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7987">
<span>PhosphoSitePlus® - comprehensive post-translational modification resource</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>The Weizmann Institute of Science GeneCards and MalaCards databases</li>
<ul>
<li>
<a target="_blank" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=BMPR1B" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8598">
<span>GeneCard for BMPR1B</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Research Materials</span>
</a>
<ul>
<li><span class="order-rsc"></span>Addgene Non-profit plasmid repository</li>
<ul>
<li>
<a target="_blank" href="https://addgene.org//browse/gene/658" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5304">
<span>Get Plasmids - Addgene</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>Bio-Techne</li>
<ul>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/bmpr-ib-alk-6/lysates?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=lysates" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>BMPR-IB/ALK-6 Lysates</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/bmpr-ib-alk-6/antibodies?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=antibodies" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>BMPR-IB/ALK-6 Antibodies</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>Creative Biogene</li>
<ul>
<li>
<a target="_blank" href="https://www.creative-biogene.com/genesearch/BMPR1B.html" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10094">
<span>bone morphogenetic protein receptor, type IB</span>
</a>
</li>
</ul>
<li>ExactAntigen/Labome</li>
<ul>
<li>
<a target="_blank" href="https://www.labome.com/review/gene/human/BMPR1B-antibody.html" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5753">
<span>reagent review</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.labome.com/gene/human/BMPR1B-antibody.html" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5753">
<span>reagents</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GenScript latest version of gene cDNA ORF Clone</li>
<ul>
<li>
<a target="_blank" href="http://www.genscript.com/gene/658" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8012">
<span>GenScript latest version of gene cDNA ORF Clone</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GeneCopoeia Inc.</li>
<ul>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=26&amp;field=5&amp;key=658" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order TALEN/CRISPR clones</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?tax_id=9606&amp;field=5&amp;prt=16&amp;key=658" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order miRNA target clones</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=1&amp;field=5&amp;key=658" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order full-length ORF clone</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GeneTex Inc</li>
<ul>
<li>
<a target="_blank" href="https://www.genetex.com/Product/Search?geneid=658&amp;type=03&amp;page=1" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8117">
<span>Find Recombinant Proteins and Peptides</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.genetex.com/Product/Search?geneid=658&amp;type=01&amp;page=1" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8117">
<span>Find Quality Antibodies</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>Kazusa DNA Research Institute</li>
<ul>
<li>
<a target="_blank" href="http://www.kazusa.or.jp/kop/dsearch/symsearch.cgi?keyword=BMPR1B;" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=3267">
<span>Kazusa DNA Research Institute</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>OriGene</li>
<ul>
<li>
<a target="_blank" href="https://www.origene.com/search?q=Bmpr1b" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7994">
<span>Order Bmpr1b cDNA clone/Protein/Antibody/RNAi</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Tools</span>
</a>
<ul>
<li><span class="free-rsc"></span>GeneMANIA</li>
<ul>
<li>
<a target="_blank" href="http://genemania.org/link?o=9606&amp;g=658" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7529">
<span>GeneMANIA</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open">
<span>Miscellaneous</span>
</a>
<ul>
<li><span class="free-rsc"></span>Reactome</li>
<ul>
<li>
<a target="_blank" href="https://reactome.org/PathwayBrowser/#/R-HSA-162582" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=4914">
<span>Reactome Event:Signal Transduction</span>
</a>
</li>
<li>
<a target="_blank" href="https://reactome.org/content/query?q=UniProt:O00238" ref="itool=Gene_FullReport&amp;uid=658&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=4914">
<span>Reactome Entity:O00238</span>
</a>
</li>
</ul>
</ul>
</div>
</div>
</div>
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<h2 class="offscreen_noflow">Supplemental Content</h2>
<div id="gene-sidebar">
<div>
<div class="portlet brieflink dis-table-of-contents">
<div class="portlet_head">
<div class="portlet_title">
<h3>Table of contents</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_TableOfContents" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter"></a>
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<div class="portlet_content">
<ul>
<li class="">
<a href="#summary">Summary</a>
</li>
<li class="">
<a href="#genomic-context">Genomic context</a>
</li>
<li class="">
<a href="#genomic-regions-transcripts-products">Genomic regions, transcripts, and products</a>
</li>
<li class="">
<a href="#gene-expression">Expression</a>
</li>
<li class="">
<a href="#bibliography">Bibliography</a>
</li>
<li class="">
<a href="#phenotypes">Phenotypes</a>
</li>
<li class="">
<a href="#variation">Variation</a>
</li>
<li class="">
<a href="#HIV-1-interactions">HIV-1 interactions</a>
</li>
<li class="">
<a href="#pathways">Pathways from PubChem</a>
</li>
<li class="">
<a href="#interactions">Interactions</a>
</li>
<li class="">
<a href="#general-gene-info">General gene information</a>
<div class="subsection-links"><a href="#gene-markers">Markers</a>, <a href="#homology">Homology</a>, <a href="#gene-ontology">Gene Ontology</a></div>
</li>
<li class="">
<a href="#general-protein-info">General protein information</a>
</li>
<li class="">
<a href="#reference-sequences">NCBI Reference Sequences (RefSeq)</a>
</li>
<li class="">
<a href="#related-sequences">Related sequences</a>
</li>
<li class="">
<a href="#additional-links">Additional links</a>
<div class="subsection-links">
<a href="#lsdb">Locus-specific Databases</a>
</div>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-genomesbrowser brieflink dis-genomesbrowser">
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<div class="portlet_head">
<div class="portlet_title">
<h3>Related information</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter"></a>
</div>
<div class="portlet_content DiscoveryDbLinks">
<ul>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clone/order/gene/658" ref="log$=recordlinks">Order cDNA clone</a>
<div class="brieflinkpop offscreen_noflow">Order cDNA clone</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/structure?LinkName=gene_structure&amp;from_uid=658" ref="log$=recordlinks">3D structures</a>
<div class="brieflinkpop offscreen_noflow">3D structure of a gene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_alltarget_list&amp;from_uid=658" ref="log$=recordlinks">BioAssay by Target (List)</a>
<div class="brieflinkpop offscreen_noflow">BioAssays related to the gene by protein target or RNAi target</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="//pubchem.ncbi.nlm.nih.gov/assay/bioactivity.html?geneid=658" ref="log$=recordlinks">BioAssay by Target (Summary)</a>
<div class="brieflinkpop offscreen_noflow">Summarized PubChem Data on the gene, showing the active data by default</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_target&amp;from_uid=658" ref="log$=recordlinks">BioAssay, by Gene target</a>
<div class="brieflinkpop offscreen_noflow">PubChem BioAssays done on the Gene target</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai&amp;from_uid=658" ref="log$=recordlinks">BioAssays, RNAi Target, Tested</a>
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/bioproject?LinkName=gene_bioproject&amp;from_uid=658" ref="log$=recordlinks">BioProjects</a>
<div class="brieflinkpop offscreen_noflow">BioProjects related to a gene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/biosystems?LinkName=gene_biosystems&amp;from_uid=658" ref="log$=recordlinks">BioSystems</a>
<div class="brieflinkpop offscreen_noflow">BioSystems</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/CCDS/CcdsBrowse.cgi?REQUEST=GENEID&amp;DATA=658" ref="log$=recordlinks">CCDS</a>
<div class="brieflinkpop offscreen_noflow">Link to CCDS</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar&amp;from_uid=658" ref="log$=recordlinks">ClinVar</a>
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/cdd?LinkName=gene_cdd&amp;from_uid=658" ref="log$=recordlinks">Conserved Domains</a>
<div class="brieflinkpop offscreen_noflow">Related CDD</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/dbvar?LinkName=gene_dbvar&amp;from_uid=658" ref="log$=recordlinks">dbVar</a>
<div class="brieflinkpop offscreen_noflow">Link from Gene to dbVar</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc&amp;from_uid=658" ref="log$=recordlinks">Full text in PMC</a>
<div class="brieflinkpop offscreen_noflow">PMC links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc_nucleotide&amp;from_uid=658" ref="log$=recordlinks">Full text in PMC_nucleotide</a>
<div class="brieflinkpop offscreen_noflow">Full text in PubMedCentral identified from shared sequence links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/sparcle?LinkName=gene_sparcle&amp;from_uid=658" ref="log$=recordlinks">Functional Class</a>
<div class="brieflinkpop offscreen_noflow">Functional class of the sequence domain architecture</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gene?LinkName=gene_gene_neighbors&amp;from_uid=658" ref="log$=recordlinks">Gene neighbors</a>
<div class="brieflinkpop offscreen_noflow">Overlapping genes and two nearest non-overlapping genes on either side</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gene?LinkName=gene_gene_h3k4me3&amp;from_uid=658" ref="log$=recordlinks">Genes with a similar H3K4me3 profile</a>
<div class="brieflinkpop offscreen_noflow">Genes with a similar profile of promoter-activating H3K4me3 modifications across several tissue types</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/genome?LinkName=gene_genome&amp;from_uid=658" ref="log$=recordlinks">Genome</a>
<div class="brieflinkpop offscreen_noflow">Related Genome</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/geoprofiles?LinkName=gene_geoprofiles&amp;from_uid=658" ref="log$=recordlinks">GEO Profiles</a>
<div class="brieflinkpop offscreen_noflow">Related GEO</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gtr/tests/?term=658[geneid]" ref="log$=recordlinks">GTR</a>
<div class="brieflinkpop offscreen_noflow">Tests for this gene in the NIH Genetic Testing Registry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/homologene?LinkName=gene_homologene&amp;from_uid=658" ref="log$=recordlinks">HomoloGene</a>
<div class="brieflinkpop offscreen_noflow">Related HomoloGene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/medgen?LinkName=gene_medgen_diseases&amp;from_uid=658" ref="log$=recordlinks">MedGen</a>
<div class="brieflinkpop offscreen_noflow">Related information in MedGen</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore&amp;from_uid=658" ref="log$=recordlinks">Nucleotide</a>
<div class="brieflinkpop offscreen_noflow">Link to related Nucleotide entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/omim?LinkName=gene_omim&amp;from_uid=658" ref="log$=recordlinks">OMIM</a>
<div class="brieflinkpop offscreen_noflow">Link to related OMIM entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/probe?LinkName=gene_probe&amp;from_uid=658" ref="log$=recordlinks">Probe</a>
<div class="brieflinkpop offscreen_noflow">Related Probe entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein&amp;from_uid=658" ref="log$=recordlinks">Protein</a>
<div class="brieflinkpop offscreen_noflow">Link to related protein entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pccompound?LinkName=gene_pccompound&amp;from_uid=658" ref="log$=recordlinks">PubChem Compound</a>
<div class="brieflinkpop offscreen_noflow">PubChem Compounds</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcsubstance?LinkName=gene_pcsubstance&amp;from_uid=658" ref="log$=recordlinks">PubChem Substance</a>
<div class="brieflinkpop offscreen_noflow">PubChem Substances</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed&amp;from_uid=658" ref="log$=recordlinks">PubMed</a>
<div class="brieflinkpop offscreen_noflow">Link to related PubMed entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_rif&amp;from_uid=658" ref="log$=recordlinks">PubMed (GeneRIF)</a>
<div class="brieflinkpop offscreen_noflow">Link to related PubMed article from GeneRIFs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_citedinomim&amp;from_uid=658" ref="log$=recordlinks">PubMed (OMIM)</a>
<div class="brieflinkpop offscreen_noflow">Gene links to PubMed derived from omim_pubmed_cited links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_pmc_nucleotide&amp;from_uid=658" ref="log$=recordlinks">PubMed(nucleotide/PMC)</a>
<div class="brieflinkpop offscreen_noflow">Citations in PubMed identified from shared sequence and PMC links.</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein_refseq&amp;from_uid=658" ref="log$=recordlinks">RefSeq Proteins</a>
<div class="brieflinkpop offscreen_noflow">Link to Protein RefSeqs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore_refseqrna&amp;from_uid=658" ref="log$=recordlinks">RefSeq RNAs</a>
<div class="brieflinkpop offscreen_noflow">Link to Nucleotide RefSeq RNAs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/nuccore/219521908?report=graph" ref="log$=recordlinks">RefSeqGene</a>
<div class="brieflinkpop offscreen_noflow">Link to Nucleotide RefSeqGenes</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar_specific&amp;from_uid=658" ref="log$=recordlinks">Related gene-specific medical variations</a>
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/snp?LinkName=gene_snp&amp;from_uid=658" ref="log$=recordlinks">SNP</a>
<div class="brieflinkpop offscreen_noflow">Related SNP records</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/taxonomy?LinkName=gene_taxonomy&amp;from_uid=658" ref="log$=recordlinks">Taxonomy</a>
<div class="brieflinkpop offscreen_noflow">Link to related taxonomy entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/variation/view/?q=658[geneid]" ref="log$=recordlinks">Variation Viewer</a>
<div class="brieflinkpop offscreen_noflow">Related Variants</div>
</li>
</ul>
</div>
</div>
<div class="portlet dis-links-to-other-res brieflink">
<div class="portlet_head">
<div class="portlet_title">
<h3>Links to other resources</h3>
</div>
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</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1077">HGNC</a>
</li>
<li>
<a href="http://www.ensembl.org/id/ENSG00000138696">Ensembl</a>
</li>
<li>
<a href="https://www.alliancegenome.org/gene/HGNC:1077">AllianceGenome</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=geneid&amp;org=9606&amp;l=658">AceView</a>
</li>
<li>
<a href="http://databases.lovd.nl/shared/genes/BMPR1B">BMPR1B database</a>
</li>
<li>
<a href="http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&amp;position=NM_001256792">UCSC</a>
</li>
<li>
<a href="https://genecollections.nci.nih.gov/MGC/?ORG=Hs&amp;LIST=BC047773">MGC</a>
</li>
<li>
<a href="https://phgkb.cdc.gov/PHGKB/huGEPedia.action?firstQuery=BMPR1B&amp;geneID=658&amp;typeOption=gene&amp;which=2&amp;pubOrderType=pubD&amp;typeSubmit=GO&amp;check=y">HuGE Navigator</a>
</li>
<li>
<a href="http://www.genome.jp/dbget-bin/www_bget?hsa:658">KEGG</a>
</li>
<li>
<a href="https://reactome.org/content/query?q=UniProt:O00238">Reactome</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-general-info">
<div class="portlet_head">
<div class="portlet_title">
<h3>General information</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GeneralInfo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="/pmc/?term=PMC4383897+OR+PMC3013746+OR+PMC1761442+OR+PMC539985">About Gene</a>
</li>
<li>
<a href="/books/NBK3840">FAQ</a>
</li>
<li>
<a href="https://ftp.ncbi.nlm.nih.gov/gene/">FTP site</a>
</li>
<li>
<a href="/books/NBK3841/">Help</a>
</li>
<li>
<a href="/books/NBK3842/">My NCBI help</a>
</li>
<li>
<a href="/books/NBK21085/">NCBI Handbook</a>
</li>
<li>
<a href="/gene/statistics/">Statistics</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-related-sites">
<div class="portlet_head">
<div class="portlet_title">
<h3>Related sites</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_RelatedSites" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://www.ncbi.nlm.nih.gov/BLAST">BLAST</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/genome">Genome</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/bioproject">BioProject</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/genome/gdv/">Genome Data Viewer</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/geo">GEO</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/omim">OMIM</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/probe">Probe</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/RefSeq">RefSeq</a>
</li>
</ul>
</div>
</div>
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<div class="portlet_head">
<div class="portlet_title">
<h3>Feedback</h3>
</div>
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<div class="portlet_content">
<ul>
<li>
<a href="https://support.ncbi.nlm.nih.gov/ics/support/ticketnewwizard.asp?style=classic&amp;deptID=28049">Contact Help Desk</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/RefSeq/update.cgi?geneid=658&amp;symbol=BMPR1B">Submit Correction</a>
</li>
<li>
<a href="/gene/submit-generif?geneId=658&amp;sym=BMPR1B&amp;name=bone morphogenetic protein receptor type 1B&amp;org=Homo sapiens">Submit GeneRIF</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-subscription">
<div class="portlet_head">
<div class="portlet_title">
<h3>Subscription</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Subscription.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_Subscription" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Subscription.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://www.ncbi.nlm.nih.gov/mailman/listinfo/refseq-announce">RefSeq</a>
</li>
</ul>
</div>
</div>
</div>
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<h3>Recent activity</h3>
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<ul id="activity">
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67c9d71484f3725e59ff4eda">BMPR1B bone morphogenetic protein receptor type 1B [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">BMPR1B bone morphogenetic protein receptor type 1B [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:658</div></div>
<div class="tertiary">Gene</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67c9d712f4a390645eff4ca6">bone morphogenetic protein receptor type-1B isoform b precursor [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">bone morphogenetic protein receptor type-1B isoform b precursor [Homo sapiens]<div class="brieflinkpopdesc">gi|4502431|ref|NP_001194.1|</div></div>
<div class="tertiary">Protein</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67c9d70e84f3725e59ff2560">bone morphogenetic protein receptor type-1A isoform 3 precursor [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">bone morphogenetic protein receptor type-1A isoform 3 precursor [Homo sapiens]<div class="brieflinkpopdesc">gi|41349437|ref|NP_004320.2|</div></div>
<div class="tertiary">Protein</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67c9d70df4a390645eff2a36">BMP7 bone morphogenetic protein 7 [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">BMP7 bone morphogenetic protein 7 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:655</div></div>
<div class="tertiary">Gene</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67c9d70b84f3725e59ff1503">bone morphogenetic protein 7 preproprotein [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">bone morphogenetic protein 7 preproprotein [Homo sapiens]<div class="brieflinkpopdesc">gi|4502427|ref|NP_001710.1|</div></div>
<div class="tertiary">Protein</div>
</li>
</ul>
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