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<div class="search"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="pubmed">PubMed</option><option value="clinvar">ClinVar</option><option value="medgen">MedGen</option><option value="books" class="last">Books</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly" data-ac_dict="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene" selected="selected" data-ac_dict="gene">Gene</option><option value="genome" data-ac_dict="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen">MedGen</option><option value="mesh">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore" data-ac_dict="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein" data-ac_dict="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search Gene. Use up and down arrows to choose an item from the autocomplete." value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="dictionary:'gene',disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'yes',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div><ul class="searchlinks inline_list"><set></set><li><a href="/gene/advanced">Advanced</a></li><li class="help"><a id="help" class="jig-ncbihelpwindow" target="ncbihelp" name="help" href="/books/NBK3841/">Help</a></li></ul></div>
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<div class="facet_cont" data-db="gene" data-default_grps="fg_gene-sources,fg_categories,fg_sequence-content,fg_status" data-sd="db:'gene',op:'select',term:'',qk:'6840',linkname:'',idsfromresult:'6464',extra:''"><ul class="facet" data-filter_id="gene-sources" id="_gene-sources"><li class="filter_grp "><div class="clearfix"><h3>Gene sources</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="genomic">Genomic</a></li></ul></li></ul><ul class="facet" data-filter_id="categories" id="_categories"><li class="filter_grp "><div class="clearfix"><h3>Categories</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="alt-splicing">Alternatively spliced</a></li><li class="fil_val"><a href="#" data-value_id="annotated-genes">Annotated genes</a></li><li class="fil_val"><a href="#" data-value_id="gene-type-protein-coding">Protein-coding</a></li></ul></li></ul><ul class="facet" data-filter_id="sequence-content" id="_sequence-content"><li class="filter_grp "><div class="clearfix"><h3>Sequence content</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="seq-ccds">CCDS</a></li><li class="fil_val"><a href="#" data-value_id="seq-ensembl">Ensembl</a></li><li class="fil_val"><a href="#" data-value_id="refseq">RefSeq</a></li><li class="fil_val"><a href="#" data-value_id="seq-refseqgene">RefSeqGene</a></li></ul></li></ul><ul class="facet" data-filter_id="status" id="_status"><li class="filter_grp "><div class="clearfix"><h3>Status</h3><a href="#" data-value_id="" class="clear clear_show">Clear</a></div><ul><li class="fil_val selected"><a href="#" data-value_id="current-only">Current</a><span class="fcount">(1)</span></li></ul></li></ul><div id="chr-location-facet-wrapper" data-bid="MCID_67c9fd3e69195c35ad751bae" data-hid="MCID_67c90f2d64f30b25346ccae2" data-qky="6840" class="disabled" style="display:none"><ul class="facet" data-filter_id="chromosomal-region" id="_chromosomal-region" data-of="yes"><li class="filter_grp of_grp"><div class="clearfix"><h3>Chromosome locations</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><a id="facet_ofchromosomal-region" href="#facet_of_divchromosomal-region" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'middle left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '375px'" data-value_id="fetch_more">more...</a><div id="facet_of_divchromosomal-region" style="display:none;" class="of_popup"><h4>Chromosome locations</h4><label for="organism-filter" style="width:100%;margin-bottom:.2em;" class="">Select an organism by typing or scrolling</label><input type="text" placeholder="Enter text to narrow down the list" id="organism-filter" style="width:98%;" autocomplete="off" /><br /><div id="chr-region-tax-list"><select id="of_chromosomal-region" size="9" class="chr-region-tax-list" style="width:100%;"></select></div><div id="chr-location-info-ctrl" data-disabled="disabled"><div class="chr-field"><label for="chr-name">Chromosome</label><br /><select id="chr-name" class="chr-field" disabled="disabled"></select></div><div class="chr-field"><label for="chr-from">From</label><br /><input type="text" name="chr-from" id="chr-from" disabled="disabled" class="chr-field" /></div><div class="chr-field"><label for="chr-to">To</label><br /><input type="text" name="chr-to" id="chr-to" disabled="disabled" class="chr-field" /></div></div><div class="actions clearfix"><button class="jig-ncbibutton of_add apply-chr" data-jigconfig="'color': 'ui-ncbibutton-blue'">Apply</button></div></div></ul></li></ul></div><ul class="facet facet_reset"><li><a href="#" data-value_id="reset">Clear all</a></li></ul><ul class="facet_tools"><li><a id="more_filter_groups_link" href="#more_filter_groups" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'top left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '180px'">
Show additional filters</a></li><div id="more_filter_groups" style="display:none;" class="facets_dialog"><button class="ui-ncbipopper-close-button ui-ncbipopper-close-button-generated ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-blue" generated="true" role="button" aria-disabled="false"><span class="ui-button-text">x</span></button><h4>Additional filters</h4><ul class="filter_groups_more facet"><li><input type="checkbox" id="fg_gene-sources" /><label for="fg_gene-sources">Gene sources</label></li><li><input type="checkbox" id="fg_categories" /><label for="fg_categories">Categories</label></li><li><input type="checkbox" id="fg_sequence-content" /><label for="fg_sequence-content">Sequence content</label></li><li><input type="checkbox" id="fg_status" /><label for="fg_status">Status</label></li><li><input type="checkbox" id="fg_chromosomal-region" /><label for="fg_chromosomal-region">Chromosome locations</label></li><li><input id="fg_field_search" type="checkbox" /><label for="fg_field_search">Search fields</label></li></ul><div class="actions clearfix"><button class="filter_groups_more_apply jig-ncbibutton primary-action" id="filter_groups_apply" data-jigconfig="'color': 'ui-ncbibutton-blue'">Show</button></div></div></ul><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetsUrlFrag" sid="1" type="hidden" value="filters=current-only" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetSubmitted" sid="1" type="hidden" value="false" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.BMFacets" sid="1" type="hidden" value="" /></div>
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<h1 class="title" id="gene-name"><span class="gn" style="padding-right:.5em;">SHC1</span> SHC adaptor protein 1 [ <em class="tax">Homo sapiens</em> (human)
]
</h1>
<span class="geneid">Gene ID: 6464, updated on
4-Mar-2025</span>
</div>
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<div class="rprt-body">
<div class="rprt-section gene-summary">
<section class="rprt-section-header" id="summary">
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<div id="summaryDiv" class="section">
<dl id="summaryDl">
<dt class="noline"> Official
Symbol</dt>
<dd class="noline">SHC1<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
<dt> Official
Full Name</dt>
<dd>SHC adaptor protein 1<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
<dt>Primary source</dt>
<dd>
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10840" data-gblink-text="Ensembl">HGNC:HGNC:10840</a>
</dd>
<dt>See related</dt>
<dd>
<a href="http://www.ensembl.org/id/ENSG00000160691" data-gblink-text="Ensembl" class="genome-browser-link" data-genome-browser-link-sort="5" data-gb-url="http://www.ensembl.org/loc/ENSG00000160691">Ensembl:ENSG00000160691</a>
<a href="https://www.ncbi.nlm.nih.gov/omim/600560" data-gblink-text="Ensembl" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=600560">MIM:600560;</a>
<a href="https://www.alliancegenome.org/gene/HGNC:10840" data-gblink-text="Ensembl" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=HGNC:10840">AllianceGenome:HGNC:10840</a>
</dd>
<dt>Gene type</dt>
<dd>protein coding</dd>
<dt>RefSeq status</dt>
<dd>REVIEWED</dd>
<dt>Organism</dt>
<dd class="tax">
<a href="/Taxonomy/Browser/wwwtax.cgi?id=9606" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=9606">Homo sapiens</a>
</dd>
<dt>Lineage</dt>
<dd class="tax">Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo</dd>
<dt>Also known as</dt>
<dd>SHC; SHCA</dd>
<dt>Summary</dt>
<dd>This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]</dd>
<dt>Expression</dt>
<dd>Ubiquitous expression in fat (RPKM 25.3), gall bladder (RPKM 24.7) and 25 other tissues <a href="#gene-expression">See more</a></dd>
<dt>Orthologs</dt>
<dd class="ortholog-links">
<a href="https://www.ncbi.nlm.nih.gov/gene/20416">mouse</a>
<a href="/gene/6464/ortholog/">all</a>
</dd>
<dt style="padding-top:.5em;">
<span class="new-icon">NEW</span>
</dt>
<dd style="padding-top:.5em;">
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/6464/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="gene_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Gene table</a></strong>
<br />
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/6464/products/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="transcript_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Transcript table</a></strong>
</dd>
</dl>
</div>
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<div class="rprt-section gene-genomic-context">
<section class="rprt-section-header" id="genomic-context">
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<span class="ui-ncbitoggler-master-text">Genomic context</span>
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</section>
<div class="rprt-section-body">
<div class="gc_cont">
<div class="gt_cont_contents">
<div style="float:right"><span>See SHC1 in </span><a href="/genome/gdv/?context=gene&amp;acc=6464" class="link-to-gdv genome-browser-link" data-genome-browser-link-sort="1" data-acc="GCF_000001405.40">Genome Data Viewer</a> </div>
<dl class="dl-chr-info" style="float:left;margin-top:0;">
<dt>Location: </dt>
<dd>
<span style="display:inline-block;">1q21.3</span>
</dd>
</dl>
</div>
<dl class="dl-chr-info exon-count">
<dt>Exon count: </dt>
<dd>15</dd>
</dl>
<div class="ui-ncbigrid-outer-div" id="genomic-context-tbl-location">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="">
<thead>
<tr>
<th style="max-width:15%">Annotation release</th>
<th style="max-width:10%">Status</th>
<th>Assembly</th>
<th>
<span title="Chromosome">Chr</span>
</th>
<th>Location</th>
</tr>
</thead>
<tbody>
<tr>
<td>RS_2024_08</td>
<td>current</td>
<td>GRCh38.p14 (<a href="/assembly/GCF_000001405.40/" ref="ncbi_uid=6464&amp;link_uid=GCF_000001405.40">GCF_000001405.40</a>)</td>
<td>1</td>
<td>NC_000001.11 (154962298..154974376, complement) </td>
</tr>
<tr>
<td>RS_2024_08</td>
<td>current</td>
<td>T2T-CHM13v2.0 (<a href="/assembly/GCF_009914755.1/" ref="ncbi_uid=6464&amp;link_uid=GCF_009914755.1">GCF_009914755.1</a>)</td>
<td>1</td>
<td>NC_060925.1 (154101659..154113737, complement) </td>
</tr>
<tr>
<td>RS_2024_09</td>
<td>previous assembly</td>
<td>GRCh37.p13 (<a href="/assembly/GCF_000001405.25/" ref="ncbi_uid=6464&amp;link_uid=GCF_000001405.25">GCF_000001405.25</a>)</td>
<td>1</td>
<td>NC_000001.10 (154934774..154946852, complement) </td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<p class="withnote margin_t2em"><strong>Chromosome 1 - NC_000001.11</strong><img usemap="#nbrMap6464_568815597" border="0" alt="Genomic Context describing neighboring genes" src="/gutils/geneneighb.fcgi?geneid=6464&amp;nuc_gi=568815597&amp;n0=PBXIP1&amp;n1=LOC127270435&amp;n2=LOC129931526&amp;n3=LOC127270436&amp;n4=PYGO2&amp;n5=LOC127270437&amp;n6=LOC127270438&amp;n7=PYGO2-AS1&amp;n8=SHC1&amp;n9=LOC127270440&amp;n10=LOC127270441&amp;n11=LOC129931527&amp;n12=LOC129931528&amp;n13=CKS1B&amp;n14=LOC129931529&amp;n15=LOC129931530&amp;n16=MIR4258&amp;n17=LOC127270442&amp;n18=LOC127270443&amp;n19=FLAD1&amp;n20=LOC127270444" /><map name="nbrMap6464_568815597" id="nbrMap6464_568815597">
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr1:154917055-154917556')" onMouseOut="hidetip()" coords="6,23,76,31" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154917055-154917556" href="/gene/127270435" />
<area shape="rect" onMouseOver="showtip(this,event,'PBX homeobox interacting protein 1')" onMouseOut="hidetip()" coords="32,35,152,43" alt="Neighboring gene PBX homeobox interacting protein 1" href="/gene/57326" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 1796')" onMouseOut="hidetip()" coords="59,47,129,55" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1796" href="/gene/129931526" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr1:154924461-154924960')" onMouseOut="hidetip()" coords="60,59,130,67" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154924461-154924960" href="/gene/127270436" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr1:154931761-154932260')" onMouseOut="hidetip()" coords="113,23,183,31" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154931761-154932260" href="/gene/127270437" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac hESC enhancers GRCh37_chr1:154933865-154934605 and GRCh37_chr1:154934606-154935345')" onMouseOut="hidetip()" coords="128,71,202,79" alt="Neighboring gene H3K27ac hESC enhancers GRCh37_chr1:154933865-154934605 and GRCh37_chr1:154934606-154935345" href="/gene/127270438" />
<area shape="rect" onMouseOver="showtip(this,event,'pygopus family PHD finger 2')" onMouseOut="hidetip()" coords="132,47,194,55" alt="Neighboring gene pygopus family PHD finger 2" href="/gene/90780" />
<area shape="rect" onMouseOver="showtip(this,event,'PYGO2 and SHC1 antisense RNA 1')" onMouseOut="hidetip()" coords="145,59,200,67" alt="Neighboring gene PYGO2 and SHC1 antisense RNA 1" href="/gene/101928120" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154942000-154942550')" onMouseOut="hidetip()" coords="188,23,258,31" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154942000-154942550" href="/gene/127270440" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154942551-154943101')" onMouseOut="hidetip()" coords="192,83,262,91" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154942551-154943101" href="/gene/127270441" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 1798')" onMouseOut="hidetip()" coords="222,47,292,55" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1798" href="/gene/129931527" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 1371')" onMouseOut="hidetip()" coords="224,59,294,67" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1371" href="/gene/129931528" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 1799')" onMouseOut="hidetip()" coords="227,71,297,79" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1799" href="/gene/129931529" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 1800')" onMouseOut="hidetip()" coords="229,95,299,103" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1800" href="/gene/129931530" />
<area shape="rect" onMouseOver="showtip(this,event,'microRNA 4258')" onMouseOut="hidetip()" coords="258,107,303,115" alt="Neighboring gene microRNA 4258" href="/gene/100423020" />
<area shape="rect" onMouseOver="showtip(this,event,'CDC28 protein kinase regulatory subunit 1B')" onMouseOut="hidetip()" coords="261,23,322,31" alt="Neighboring gene CDC28 protein kinase regulatory subunit 1B" href="/gene/1163" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154953875-154954472')" onMouseOut="hidetip()" coords="275,83,345,91" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154953875-154954472" href="/gene/127270442" />
<area shape="rect" onMouseOver="showtip(this,event,'OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154955073-154955670')" onMouseOut="hidetip()" coords="284,119,354,127" alt="Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154955073-154955670" href="/gene/127270443" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154958088-154958777')" onMouseOut="hidetip()" coords="306,35,376,43" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154958088-154958777" href="/gene/127270444" />
<area shape="rect" onMouseOver="showtip(this,event,'flavin adenine dinucleotide synthetase 1')" onMouseOut="hidetip()" coords="324,23,423,31" alt="Neighboring gene flavin adenine dinucleotide synthetase 1" href="/gene/80308" />
</map>
</p>
</div>
</div>
<div class="rprt-section gene-genomic-regions-transcripts-products">
<section class="rprt-section-header" id="genomic-regions-transcripts-products">
<h2 id="header-genomic-regions-transcripts-products">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-regions-transcripts-products .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Genomic regions, transcripts, and products</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Genomic_Regions_Transcripts_a" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<div style="text-align:right;">Go to <a href="#reference-sequences">reference sequence details</a></div>
</div>
<div>
<p class="choose">
<label for="accession" class="label">Genomic Sequence: </label>
<select name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.accessionList" sid="1" id="accessionList" data-taxid="9606" data-geneid="6464">
<option value="NC_000001.11_154962297_154974375">NC_000001.11 Chromosome 1 Reference GRCh38.p14 Primary Assembly</option>
<option value="NG_029028.1_8736_17185">NG_029028.1 RefSeqGene</option>
<option value="NC_060925.1_154101658_154113736">NC_060925.1 Chromosome 1 Alternate T2T-CHM13v2.0</option>
<option value="NC_000001.10_154934773_154946851">NC_000001.10 Chromosome 1 Reference GRCh37.p13 Primary Assembly</option>
</select>
</p>
</div>
<div id="NC_000001" class="divAccession">
<div class="seq-viewer">
<p class="note-link">
<strong>Go to nucleotide:</strong>
<a title="Nucleotide Graphic report" href="/nuccore/NC_000001.11?report=graph&amp;from=154960485&amp;to=154976187&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=NC_000001.11">Graphics</a>
<a title="Nucleotide FASTA report" href="/nuccore/NC_000001.11?report=fasta&amp;from=154962298&amp;to=154974376&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=NC_000001.11">FASTA</a>
<a title="Nucleotide GenBank report" href="/nuccore/NC_000001.11?report=genbank&amp;from=154962298&amp;to=154974376&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=NC_000001.11">GenBank</a>
</p>
<div id="divNC_000001" class="SeqViewerApp" style="clear:both;" data-sv="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000001.11&amp;from=154960485&amp;to=154976187&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40">
<a href="?appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000001.11&amp;from=154960485&amp;to=154976187&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40"></a>
</div>
</div>
</div>
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000001.11" sid="1" type="hidden" id="nucleotideLink_NC_000001_11_154962297_154974375" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_000001.11?report=graph&amp;amp;from=154960485&amp;amp;to=154976187&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.40&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=6464&amp;amp;link_uid=NC_000001.11&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_000001.11?report=fasta&amp;amp;from=154962298&amp;amp;to=154974376&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=6464&amp;amp;link_uid=NC_000001.11&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_000001.11?report=genbank&amp;amp;from=154962298&amp;amp;to=154974376&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=6464&amp;amp;link_uid=NC_000001.11&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000001.11" sid="1" type="hidden" id="relString_NC_000001_11_154962297_154974375" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_000001.11&amp;amp;from=154960485&amp;amp;to=154976187&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.40" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NG_029028.1" sid="1" type="hidden" id="nucleotideLink_NG_029028_1_8736_17185" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NG_029028.1?report=graph&amp;amp;from=7469&amp;amp;to=18452&amp;amp;tracks=[key:sequence_track,name:Sequence,display_name:Sequence,category:Sequence,annots:Sequence,ShowLabel:false][key:gene_model_track,name:Genes---Unnamed,display_name:Genes,annots:Unnamed,Options:ShowAllButGenes,SNPs:false,CDSProductFeats:false,ShowLabelsForAllFeatures:true,HighlightMode:2][key:SNP_track,name:SNP,annots:SNP,Layout:Adaptive][key:SNP_Bins_track,name:Clinical Variants][key:SNP_Bins_track,name:Cited Variants][key:GWAS_track,name:GWAS Tracks,display_name:Association Results][key:alignment_track,category:Alignments,annots:Unnamed][key:alignment_track,category:Alignments,annots:NA000079160.1][key:alignment_track,category:Alignments,annots:NA000010065.1]&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=6464&amp;amp;link_uid=NG_029028.1&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NG_029028.1?report=fasta&amp;amp;from=8737&amp;amp;to=17186&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=6464&amp;amp;link_uid=NG_029028.1&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NG_029028.1?report=genbank&amp;amp;from=8737&amp;amp;to=17186&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=6464&amp;amp;link_uid=NG_029028.1&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NG_029028.1" sid="1" type="hidden" id="relString_NG_029028_1_8736_17185" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NG_029028.1&amp;amp;from=7469&amp;amp;to=18452&amp;amp;tracks=[key:sequence_track,name:Sequence,display_name:Sequence,category:Sequence,annots:Sequence,ShowLabel:false][key:gene_model_track,name:Genes---Unnamed,display_name:Genes,annots:Unnamed,Options:ShowAllButGenes,SNPs:false,CDSProductFeats:false,ShowLabelsForAllFeatures:true,HighlightMode:2][key:SNP_track,name:SNP,annots:SNP,Layout:Adaptive][key:SNP_Bins_track,name:Clinical Variants][key:SNP_Bins_track,name:Cited Variants][key:GWAS_track,name:GWAS Tracks,display_name:Association Results][key:alignment_track,category:Alignments,annots:Unnamed][key:alignment_track,category:Alignments,annots:NA000079160.1][key:alignment_track,category:Alignments,annots:NA000010065.1]" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_060925.1" sid="1" type="hidden" id="nucleotideLink_NC_060925_1_154101658_154113736" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_060925.1?report=graph&amp;amp;from=154099846&amp;amp;to=154115548&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_009914755.1&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=6464&amp;amp;link_uid=NC_060925.1&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_060925.1?report=fasta&amp;amp;from=154101659&amp;amp;to=154113737&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=6464&amp;amp;link_uid=NC_060925.1&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_060925.1?report=genbank&amp;amp;from=154101659&amp;amp;to=154113737&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=6464&amp;amp;link_uid=NC_060925.1&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_060925.1" sid="1" type="hidden" id="relString_NC_060925_1_154101658_154113736" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_060925.1&amp;amp;from=154099846&amp;amp;to=154115548&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_009914755.1" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000001.10" sid="1" type="hidden" id="nucleotideLink_NC_000001_10_154934773_154946851" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_000001.10?report=graph&amp;amp;from=154932961&amp;amp;to=154948663&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.25&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=6464&amp;amp;link_uid=NC_000001.10&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_000001.10?report=fasta&amp;amp;from=154934774&amp;amp;to=154946852&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=6464&amp;amp;link_uid=NC_000001.10&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_000001.10?report=genbank&amp;amp;from=154934774&amp;amp;to=154946852&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=6464&amp;amp;link_uid=NC_000001.10&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000001.10" sid="1" type="hidden" id="relString_NC_000001_10_154934773_154946851" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_000001.10&amp;amp;from=154932961&amp;amp;to=154948663&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.25" />
</div>
</div>
<div class="rprt-section gene-gene-expression">
<section class="rprt-section-header" id="gene-expression">
<h2 id="header-gene-expression">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-gene-expression .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Expression</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Expression" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<div style="text-align:right;">
<a href="/gene/6464/?report=expression" data-url="/gene/6464/?report=expression" id="gene-expression-see-details">See details</a>
</div>
<div id="gene-expression-app" data-url="https://www.ncbi.nlm.nih.gov/gene/6464" data-report-type="summary">
<div>
<script type="text/javascript">
window.tissues_data = {'adrenal 10wk': {'id': '6464_Adrenal_10wk_PRJNA270632', 'gene': 6464, 'source_name': 'adrenal 10wk', 'full_rpkm': 6.34293, 'exp_rpkm': 6.34, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734404594728971}, 'adrenal 16wk': {'id': '6464_Adrenal_16wk_PRJNA270632', 'gene': 6464, 'source_name': 'adrenal 16wk', 'full_rpkm': 7.08993, 'exp_rpkm': 7.09, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734404594728972}, 'adrenal 18wk': {'id': '6464_Adrenal_18wk_PRJNA270632', 'gene': 6464, 'source_name': 'adrenal 18wk', 'full_rpkm': 9.17596, 'exp_rpkm': 9.18, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734404594728973}, 'adrenal 20wk': {'id': '6464_Adrenal_20wk_PRJNA270632', 'gene': 6464, 'source_name': 'adrenal 20wk', 'full_rpkm': 6.51959, 'exp_rpkm': 6.52, 'var': 1.154724, 'project_desc': 'PRJNA270632', '_version_': 1785734404594728974}, 'heart 10wk': {'id': '6464_Heart_10wk;_PRJNA270632', 'gene': 6464, 'source_name': 'heart 10wk', 'full_rpkm': 4.54632, 'exp_rpkm': 4.55, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734404594728975}, 'heart 11wk': {'id': '6464_Heart_11wk;_PRJNA270632', 'gene': 6464, 'source_name': 'heart 11wk', 'full_rpkm': 8.01976, 'exp_rpkm': 8.02, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734404594728976}, 'heart 17wk': {'id': '6464_Heart_17wk;_PRJNA270632', 'gene': 6464, 'source_name': 'heart 17wk', 'full_rpkm': 3.83265, 'exp_rpkm': 3.83, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734404594728977}, 'heart 18wk': {'id': '6464_Heart_18wk;_PRJNA270632', 'gene': 6464, 'source_name': 'heart 18wk', 'full_rpkm': 5.50188, 'exp_rpkm': 5.5, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734404594728978}, 'heart 20wk': {'id': '6464_Heart_20wk_PRJNA270632', 'gene': 6464, 'source_name': 'heart 20wk', 'full_rpkm': 2.23262, 'exp_rpkm': 2.23, 'var': 0.667449, 'project_desc': 'PRJNA270632', '_version_': 1785734404594728979}, 'intestine 10wk': {'id': '6464_Intestine_10wk_PRJNA270632', 'gene': 6464, 'source_name': 'intestine 10wk', 'full_rpkm': 3.04246, 'exp_rpkm': 3.04, 'var': 0.01942852, 'project_desc': 'PRJNA270632', '_version_': 1785734404594728980}, 'intestine 11wk': {'id': '6464_Intestine_11wk_PRJNA270632', 'gene': 6464, 'source_name': 'intestine 11wk', 'full_rpkm': 7.37852, 'exp_rpkm': 7.38, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734404594728981}, 'intestine 15wk': {'id': '6464_Intestine_15wk_PRJNA270632', 'gene': 6464, 'source_name': 'intestine 15wk', 'full_rpkm': 6.53528, 'exp_rpkm': 6.54, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734404594728982}, 'intestine 17wk': {'id': '6464_Intestine_17wk_PRJNA270632', 'gene': 6464, 'source_name': 'intestine 17wk', 'full_rpkm': 3.72813, 'exp_rpkm': 3.73, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734404594728983}, 'intestine 20wk': {'id': '6464_Intestine_20wk_PRJNA270632', 'gene': 6464, 'source_name': 'intestine 20wk', 'full_rpkm': 6.2752, 'exp_rpkm': 6.28, 'var': 0.54574, 'project_desc': 'PRJNA270632', '_version_': 1785734404594728984}, 'kidney 10wk': {'id': '6464_Kidney_10wk_PRJNA270632', 'gene': 6464, 'source_name': 'kidney 10wk', 'full_rpkm': 5.26129, 'exp_rpkm': 5.26, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734404594728985}, 'kidney 16wk': {'id': '6464_Kidney_16wk_PRJNA270632', 'gene': 6464, 'source_name': 'kidney 16wk', 'full_rpkm': 2.55333, 'exp_rpkm': 2.55, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734404594728986}, 'kidney 20wk': {'id': '6464_Kidney_20wk_PRJNA270632', 'gene': 6464, 'source_name': 'kidney 20wk', 'full_rpkm': 1.15357, 'exp_rpkm': 1.15, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734404594728987}, 'lung 10wk': {'id': '6464_Lung_10wk_PRJNA270632', 'gene': 6464, 'source_name': 'lung 10wk', 'full_rpkm': 8.56192, 'exp_rpkm': 8.56, 'var': 0.304286, 'project_desc': 'PRJNA270632', '_version_': 1785734404594728988}, 'lung 17wk': {'id': '6464_Lung_17wk_PRJNA270632', 'gene': 6464, 'source_name': 'lung 17wk', 'full_rpkm': 9.24104, 'exp_rpkm': 9.24, 'var': 0.0586488, 'project_desc': 'PRJNA270632', '_version_': 1785734404594728989}, 'lung 20wk': {'id': '6464_Lung_20wk_PRJNA270632', 'gene': 6464, 'source_name': 'lung 20wk', 'full_rpkm': 6.96632, 'exp_rpkm': 6.97, 'var': 0.947698, 'project_desc': 'PRJNA270632', '_version_': 1785734404594728990}, 'stomach 10wk': {'id': '6464_Stomach_10wk_PRJNA270632', 'gene': 6464, 'source_name': 'stomach 10wk', 'full_rpkm': 6.22245, 'exp_rpkm': 6.22, 'var': 2.08578, 'project_desc': 'PRJNA270632', '_version_': 1785734404594728991}, 'stomach 16wk': {'id': '6464_Stomach_16wk_PRJNA270632', 'gene': 6464, 'source_name': 'stomach 16wk', 'full_rpkm': 6.42806, 'exp_rpkm': 6.43, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734404594728992}, 'stomach 18wk': {'id': '6464_Stomach_18wk_PRJNA270632', 'gene': 6464, 'source_name': 'stomach 18wk', 'full_rpkm': 8.91118, 'exp_rpkm': 8.91, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734404594728993}, 'stomach 20wk': {'id': '6464_Stomach_20wk_PRJNA270632', 'gene': 6464, 'source_name': 'stomach 20wk', 'full_rpkm': 8.66234, 'exp_rpkm': 8.66, 'var': 1.753521, 'project_desc': 'PRJNA270632', '_version_': 1785734404594728994}};
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"metadata_9606_SAMN03267777", "gene": 6464, "sample_id": "SAMN03267777", "full_rpkm": 1.15357, "exp_rpkm": 1.15, "exp_total": 48787, "project_desc": "PRJNA270632", "_version_": 1785734387344605195, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "kidney 20wk", "exp_Mcount": 10280.0}], "lung 10wk": [{"id": "metadata_9606_SAMN03267770", "gene": 6464, "sample_id": "SAMN03267770", "full_rpkm": 9.11354, "exp_rpkm": 9.11, "exp_total": 223187, "project_desc": "PRJNA270632", "_version_": 1785734387344605193, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 10wk", "exp_Mcount": 5952.75}, {"id": "metadata_9606_SAMN03267767", "gene": 6464, "sample_id": "SAMN03267767", "full_rpkm": 8.0103, "exp_rpkm": 8.01, "exp_total": 172393, "project_desc": "PRJNA270632", "_version_": 1785734387344605194, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 10wk", "exp_Mcount": 5231.26}], "lung 17wk": [{"id": "metadata_9606_SAMN03267778", 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6.42806, "exp_rpkm": 6.43, "exp_total": 164473, "project_desc": "PRJNA270632", "_version_": 1785734387344605186, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 16wk", "exp_Mcount": 6219.43}], "stomach 18wk": [{"id": "metadata_9606_SAMN03267771", "gene": 6464, "sample_id": "SAMN03267771", "full_rpkm": 8.91118, "exp_rpkm": 8.91, "exp_total": 213380, "project_desc": "PRJNA270632", "_version_": 1785734387344605185, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 18wk", "exp_Mcount": 5820.42}], "stomach 20wk": [{"id": "metadata_9606_SAMN03267765", "gene": 6464, "sample_id": "SAMN03267765", "full_rpkm": 10.5173, "exp_rpkm": 10.5, "exp_total": 194473, "project_desc": "PRJNA270632", "_version_": 1785734387342508032, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 20wk", "exp_Mcount": 4494.58}, {"id": "metadata_9606_SAMN03267781", "gene": 6464, "sample_id": "SAMN03267781", "full_rpkm": 7.51234, 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window.taxId = 9606
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<div>
<select name="p" id="project-selector">
<option value="SRP051249" selected="selected" data-bioproject="PRJNA270632">
Tissue-specific circular RNA induction during human fetal development
</option>
<option value="SRP056969" data-bioproject="PRJNA280600">
RNA sequencing of total RNA from 20 human tissues
</option>
<option value="ERP003613" data-bioproject="PRJEB4337">
HPA RNA-seq normal tissues
</option>
</select>
<ul id="project-summary">
<li id="project-summary-title">Project title:
Tissue-specific circular RNA induction during human fetal development
</li>
<li id="project-summary-desc">Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA</li>
<li id="project-summary-bioprojects">BioProject: <a href="/bioproject/PRJNA270632/">PRJNA270632</a>
</li>
<li id="project-summary-pubs">Publication:
<span><a href="/pubmed/26076956/">PMID 26076956</a></span>
</li>
<li id="project-summary-analysis-date">Analysis date: Mon Apr 2 22:54:59 2018</li>
</ul>
<div id="gene-expr-details" class="expression-chart"></div>
</div>
</div>
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</li>
<li class="gene-rif-popper">
<a href="/pubmed/35612429" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=35612429">The p66Shc Protein Mediates Insulin Resistance and Secretory Dysfunction in Pancreatic beta-Cells Under Lipotoxic Conditions.</a>
<div id="gene-popper7" class="gene-rif-popper">Title: The p66Shc Protein Mediates Insulin Resistance and Secretory Dysfunction in Pancreatic β-Cells Under Lipotoxic Conditions.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/35042950" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=35042950">The E3 ubiquitin ligase SOCS-7 reverses immunosuppression via Shc1 signaling in hepatocellular carcinoma.</a>
<div id="gene-popper8" class="gene-rif-popper">Title: The E3 ubiquitin ligase SOCS-7 reverses immunosuppression via Shc1 signaling in hepatocellular carcinoma.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/34719845" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=34719845">Genistein suppresses ox-LDL-elicited oxidative stress and senescence in HUVECs through the SIRT1-p66shc-Foxo3a pathways.</a>
<div id="gene-popper9" class="gene-rif-popper">Title: Genistein suppresses ox-LDL-elicited oxidative stress and senescence in HUVECs through the SIRT1-p66shc-Foxo3a pathways.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/34117717" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=34117717">The increased expression and aberrant methylation of SHC1 in non-small cell lung cancer: Integrative analysis of clinical and bioinformatics databases.</a>
<div id="gene-popper10" class="gene-rif-popper">Title: The increased expression and aberrant methylation of SHC1 in non-small cell lung cancer: Integrative analysis of clinical and bioinformatics databases.</div>
</li>
</ol>
</div>
<div class="submit-genrif">
<span>Submit:</span>
<a href="/gene/submit-generif/?geneId=6464&amp;sym=SHC1&amp;name=SHC adaptor protein 1&amp;org=Homo sapiens">New GeneRIF</a>
<a href="/RefSeq/update.cgi?geneid=6464&amp;symbol=SHC1;task=fixpub">Correction</a>
<a href="https://www.ncbi.nlm.nih.gov/gene?db=gene&amp;report=generif&amp;term=6464" class="seeall-generif">See all GeneRIFs (173)</a>
</div>
</div>
</div>
</div>
</div>
<div class="rprt-section gene-phenotypes">
<section class="rprt-section-header" id="phenotypes">
<h2 id="header-phenotypes">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-phenotypes .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Phenotypes</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Phenotype" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body info-phenotype">
<p class="nochild-link">
<a href="/gtr/tests/?term=SHC1[gene]">Find tests for this gene in the NIH Genetic Testing Registry (GTR)</a>
</p>
<p class="nochild-link">
<a href="/gap/PheGenI?tab=1&amp;gene=6464">Review eQTL and phenotype association data in this region using PheGenI</a>
</p>
<div>
<h3 id="ebigwascatalog">EBI GWAS Catalog</h3>
<table class="jig-ncbigrid gtr-associated-cond" data-jigconfig="isPageable: true, pageSize: 10">
<thead>
<tr>
<th class="description">Description</th>
</tr>
</thead>
<tbody>
<tr>
<td>Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/23535732">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/23535732">PubMed</a></span></div></div></div></td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<div class="rprt-section gene-variation">
<section class="rprt-section-header" id="variation">
<h2 id="header-variation">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-variation .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Variation</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.variation" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<p class="nochild-link">
<a href="/clinvar/?term=SHC1[gene]" ref="log$=recordlinks">See variants in ClinVar</a>
</p>
<p class="nochild-link">
<a href="/dbvar?LinkName=gene_dbvar&amp;from_uid=6464" ref="log$=recordlinks">See studies and variants in dbVar</a>
</p>
<p class="nochild-link">
<a href="/variation/view/?q=6464[geneid]&amp;assm=GCF_000001405.25" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh37.p13)">See Variation Viewer (GRCh37.p13)</a>
</p>
<p class="nochild-link">
<a href="/variation/view/?q=6464[geneid]" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh38)">See Variation Viewer (GRCh38)</a>
</p>
<set></set>
<set></set>
</div>
</div>
<div class="rprt-section gene-HIV-1-interactions">
<section class="rprt-section-header" id="HIV-1-interactions">
<h2 id="header-HIV-1-interactions">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-HIV-1-interactions .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">HIV-1 interactions</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.HIV1_interactions" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div class="fgrid">
<h3 id="proteininteractions">Protein interactions</h3>
<table summary="protein interactions" class="jig-ncbigrid">
<thead>
<tr>
<th id="hivprotein">Protein</th>
<th id="gene-hivprotein">Gene</th>
<th id="hivinter">Interaction</th>
<th id="hivpub">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="hivprotein">
<a href="/protein/9629358">Tat</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">SHC (Src homology 2 domain containing) transforming protein 1 is upregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 19884766" href="/pubmed/19884766">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">HIV-1 Tat activates the MAPK signaling pathway leading to the phosphorylation of Shc, a protein involved in signal transduction downstream of receptor tyrosine kinase activation</td>
<td headers="hivpub">
<a title="PubMed Id(s): 9325171" href="/pubmed/9325171">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">HIV-1 Tat-induced small GTPase Ras activation is mediated by tyrosine phosphorylation of Shc and recruitment of Grb2 in human endothelial cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 16436505" href="/pubmed/16436505">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/19172949">nucleocapsid</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">SHC (Src homology 2 domain containing) transforming protein 1 is upregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 19884766" href="/pubmed/19884766">PubMed</a>
</td>
</tr>
</tbody>
</table>
<p class="withnote">
<a class="note" href="/genome/viruses/retroviruses/hiv-1/interactions/">Go to the HIV-1, Human Interaction Database </a>
</p>
</div>
</div>
</div>
<div class="rprt-section gene-pathways">
<section class="rprt-section-header" id="pathways">
<h2 id="header-pathways">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-pathways .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Pathways from PubChem</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<ul class="geneinfo-subsec infopathway">
<iframe title="Pathways in which the gene target is involved" class="pubchem-widget" scrolling="no" src="https://pubchem.ncbi.nlm.nih.gov/gene/6464#section=Pathways&amp;embed=true&amp;hide_all_headings=true&amp;page_size=25" style="border: 0; width: 100%;"></iframe>
<script type="text/javascript" src="https://pubchem.ncbi.nlm.nih.gov/pcfe/libs/iframeResizer.min.js"></script>
<script type="text/javascript">iFrameResize({log: false, checkOrigin: false}, '.pubchem-widget')</script>
</ul>
</div>
</div>
<div class="rprt-section gene-interactions">
<section class="rprt-section-header" id="interactions">
<h2 id="header-interactions">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-interactions .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Interactions</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Interactions" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<table summary="Gene Interaction" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/6464/data/interaction/',webserviceParams: 'p$l=Ajax&amp;p$debugoutput=off', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
<thead>
<tr>
<th id="inter-prod">Products</th>
<th id="inter-interactant">Interactant</th>
<th id="inter-otherGene">Other Gene</th>
<th id="inter-compl">Complex</th>
<th id="inter-source">Source</th>
<th id="inter-pubs">Pubs</th>
<th id="inter-desc">Description</th>
</tr>
</thead>
<tbody></tbody>
</table>
</div>
</div>
<div class="rprt-section gene-general-gene-info">
<section class="rprt-section-header" id="general-gene-info">
<h2 id="header-general-gene-info">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-gene-info .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">General gene information</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.General_Gene_Information" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body" style="">
<div id="gene-markers">
<h3 id="markers">
<a class="jig-ncbitoggler">Markers</a>
</h3>
<div>
<ul class="marker odd">
<li class="marker">D11S2921 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=152074%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=152074">UniSTS:152074</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">Shc1 (e-PCR), detects polymorphism<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=532499%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=532499">UniSTS:532499</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">D8S2279 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=473907%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=473907">UniSTS:473907</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">D10S16 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=155756%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=155756">UniSTS:155756</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">D15S1477 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=474482%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=474482">UniSTS:474482</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">L17877 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=61334%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=61334">UniSTS:61334</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">D7S2830 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=4769%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=4769">UniSTS:4769</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">SHC1_7874 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=467885%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=467885">UniSTS:467885</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">L17809 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=39087%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=39087">UniSTS:39087</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">RH98253 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=86706%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=86706">UniSTS:86706</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">GDB:631802 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=158429%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=158429">UniSTS:158429</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">RH70874 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=16098%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=16098">UniSTS:16098</a></li></ul></li>
</ul>
</div>
</div>
<div>
<div class="infosec" id="Relatedpseudogenes"><h3 id="relatedpseudogenes"><a class="jig-ncbitoggler-open">Related pseudogene(s)</a></h3>
<dl class="geneinfo-subsec"><dt>2 found
 
<a href="/gene/?Term=related_functional_gene_6464%5Bgroup%5D">Review record(s) in Gene</a></dt></dl>
</div>
</div>
<div class="infosec">
<h3 id="homology">
<a class="jig-ncbitoggler-open">Homology</a>
</h3>
<ul class="geneinfo-subsec">
<li>
<a href="/gene/6464/ortholog/" id="ncbi-ortholog-link">NCBI Orthologs</a>
</li>
<a href="https://www.orthodb.org/?ncbi=6464" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8178" target="_blank">
Orthologs from OrthoDB
</a>
</ul>
</div>
<!--<component id="Gene_InfoPathway"/>-->
<div class="infosec info-comment" id="info-comment">
<h3 id="CloneNames">
<a class="jig-ncbitoggler-open">Clone Names</a>
</h3>
<ul class="geneinfo-subsec">
<li>FLJ26504 </li>
</ul>
</div>
<div class="gene-ontology infosec">
<h3 id="gene-ontology">
<a class="jig-ncbitoggler-open">
<span>Gene Ontology</span>
</a>
<a target="_blank" href="http://www.ebi.ac.uk/GOA" class="g-ontology-src" title="Provided by GOA">Provided by GOA</a>
</h3>
<div class="ontology-tables">
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Function</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0046875">enables ephrin receptor binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-1-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/12925710" target="_blank" title="PubMed ID 12925710" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=12925710">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0048408">enables epidermal growth factor binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-2-0" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005154">enables epidermal growth factor receptor binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-3-0" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005158">enables insulin receptor binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-4-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/7537849" target="_blank" title="PubMed ID 7537849" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=7537849">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005159">enables insulin-like growth factor receptor binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-5-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/7541045" target="_blank" title="PubMed ID 7541045" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=7541045">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005168">enables neurotrophin TRKA receptor binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-6-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/15488758" target="_blank" title="PubMed ID 15488758" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=15488758">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005543">enables phospholipid binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-7-0" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/14676841" target="_blank" title="PubMed ID 14676841" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=14676841">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0001784">enables phosphotyrosine residue binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-8-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/20624904" target="_blank" title="PubMed ID 20624904" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=20624904">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005515">enables protein binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-9-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/7518560,7535773,7541045,7542744,7559478,8034616,8491186,8663178,8939605,8940013,8995379,9175774,9254595,9544989,9593725,10356320,11694516,11827484,11877420,12213123,12577067,15629149,15657067,16189514,16273093,16520382,16843263,19172738,19380743,20010870,20935677,21278788,21706016,21725358,22057045,23178716,23584453,23799367,23846654,24008843,24189400,24412244,24658140,24728074,25416956,26551075,27880917,28065597,31515488,31585087,31980649,32814053,33961781,35156780,35271311,35384245,36012204" target="_blank" title="PubMed ID 7518560,7535773,7541045,7542744,7559478,8034616,8491186,8663178,8939605,8940013,8995379,9175774,9254595,9544989,9593725,10356320,11694516,11827484,11877420,12213123,12577067,15629149,15657067,16189514,16273093,16520382,16843263,19172738,19380743,20010870,20935677,21278788,21706016,21725358,22057045,23178716,23584453,23799367,23846654,24008843,24189400,24412244,24658140,24728074,25416956,26551075,27880917,28065597,31515488,31585087,31980649,32814053,33961781,35156780,35271311,35384245,36012204" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=7518560,7535773,7541045,7542744,7559478,8034616,8491186,8663178,8939605,8940013,8995379,9175774,9254595,9544989,9593725,10356320,11694516,11827484,11877420,12213123,12577067,15629149,15657067,16189514,16273093,16520382,16843263,19172738,19380743,20010870,20935677,21278788,21706016,21725358,22057045,23178716,23584453,23799367,23846654,24008843,24189400,24412244,24658140,24728074,25416956,26551075,27880917,28065597,31515488,31585087,31980649,32814053,33961781,35156780,35271311,35384245,36012204">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0030971">enables receptor tyrosine kinase binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-10-0" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005068">enables transmembrane receptor protein tyrosine kinase adaptor activity</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-11-0" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/14676841" target="_blank" title="PubMed ID 14676841" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=14676841">PubMed</a> </td>
</tr>
</tbody>
</table>
</div>
</div>
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Process</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0030036">involved_in actin cytoskeleton organization</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-1-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0001525">involved_in angiogenesis</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-2-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0098609">involved_in cell-cell adhesion</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-3-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0071363">involved_in cellular response to growth factor stimulus</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-4-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/20010870" target="_blank" title="PubMed ID 20010870" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=20010870">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0042742">involved_in defense response to bacterium</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-5-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/20624904" target="_blank" title="PubMed ID 20624904" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=20624904">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0007173">involved_in epidermal growth factor receptor signaling pathway</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-6-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0007507">involved_in heart development</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-7-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0008286">involved_in insulin receptor signaling pathway</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-8-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0008286">involved_in insulin receptor signaling pathway</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-9-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0048009">involved_in insulin-like growth factor receptor signaling pathway</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-10-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0035556">involved_in intracellular signal transduction</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-11-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0045892">involved_in negative regulation of DNA-templated transcription</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-12-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-12-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/20624904" target="_blank" title="PubMed ID 20624904" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=20624904">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0016525">involved_in negative regulation of angiogenesis</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-13-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-13-1" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/24177325" target="_blank" title="PubMed ID 24177325" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=24177325">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0043066">involved_in negative regulation of apoptotic process</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-14-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-14-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/20624904" target="_blank" title="PubMed ID 20624904" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=20624904">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0045893">involved_in positive regulation of DNA-templated transcription</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-15-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-15-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/20624904" target="_blank" title="PubMed ID 20624904" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=20624904">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0070374">involved_in positive regulation of ERK1 and ERK2 cascade</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-16-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-16-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/20624904" target="_blank" title="PubMed ID 20624904" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=20624904">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0043410">involved_in positive regulation of MAPK cascade</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-17-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-17-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/14676841" target="_blank" title="PubMed ID 14676841" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=14676841">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0043410">involved_in positive regulation of MAPK cascade</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-18-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-18-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/20624904" target="_blank" title="PubMed ID 20624904" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=20624904">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0008284">involved_in positive regulation of cell population proliferation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-19-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-19-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0071864">involved_in positive regulation of cell proliferation in bone marrow</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-20-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-20-1" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/24177325" target="_blank" title="PubMed ID 24177325" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=24177325">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0090322">involved_in regulation of superoxide metabolic process</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-21-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-21-1" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/24177325" target="_blank" title="PubMed ID 24177325" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=24177325">PubMed</a> </td>
</tr>
</tbody>
</table>
</div>
</div>
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-config="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Component</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0070435">part_of Shc-EGFR complex</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-1-2" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005829">located_in cytosol</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-2-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005925">located_in focal adhesion</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-3-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005759">located_in mitochondrial matrix</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-4-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005886">is_active_in plasma membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-5-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005886">located_in plasma membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-6-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/14676841" target="_blank" title="PubMed ID 14676841" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=14676841">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005886">located_in plasma membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-7-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
</div>
</div>
</div>
<div class="rprt-section gene-general-protein-info">
<section class="rprt-section-header" id="general-protein-info">
<h2 id="header-general-protein-info">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-protein-info .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">General protein information</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.General_Protein_Information" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<dl>
<dt>Preferred Names</dt>
<dd>SHC-transforming protein 1</dd>
</dl>
<dl>
<dt>Names</dt>
<dd>SH2 domain protein C1</dd>
<dd>SHC (Src homology 2 domain containing) transforming protein 1</dd>
<dd>SHC-transforming protein 3</dd>
<dd>SHC-transforming protein A</dd>
</dl>
</div>
</div>
<div class="rprt-section gene-reference-sequences">
<section class="rprt-section-header" id="reference-sequences">
<h2 id="header-reference-sequences">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-reference-sequences .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">NCBI Reference Sequences (RefSeq)</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.NCBI_Reference_Sequences_RefS" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<p>
<span class="new-icon">NEW</span>
<strong>Try the new <a href="/datasets/tables/genes/?table_type=transcripts&amp;ids=6464&amp;utm_source=gene&amp;utm_medium=referral&amp;utm_campaign=refseq" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report." data-ga-category="refseq" data-ga-action="click_datasets_link" data-ga-label="transcript_table">Transcript table</a></strong>
</p>
<h3 class="genomerefseqs gene_std_toggler" id="refseqset-independent">
<a class="jig-ncbitoggler-open">RefSeqs maintained independently of Annotated
Genomes</a>
</h3>
<div class="genomerefseqs_slave">
<p class="desc"> These reference sequences exist independently of genome builds. <a href="#refseq-expl" id="expl-refseg">Explain</a></p>
<p id="refseq-expl"> These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in <a href="#geneGenomic regions, transcripts, and products">Genomic regions,
transcripts, and products</a> above. </p>
<h4 id="genomic-p69784656">Genomic </h4>
<ol>
<li>
<p>NG_029028.1 RefSeqGene</p>
<dl>
<dt>Range</dt>
<dd class="rs-range">
<span>8737..17186</span>
</dd>
<dt>Download</dt>
<dd><a href="/nuccore/NG_029028.1?from=8737&amp;to=17186&amp;report=genbank" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=NG_029028.1?from=8737&amp;to=17186&amp;report=genbank">GenBank</a>, <a href="/nuccore/NG_029028.1?from=8737&amp;to=17186&amp;report=fasta" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=NG_029028.1?from=8737&amp;to=17186&amp;report=fasta">FASTA</a>, <a href="/nuccore/NG_029028.1?from=7469&amp;to=18452&amp;report=graph&amp;content=5" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=NG_029028.1?from=7469&amp;to=18452&amp;report=graph&amp;content=5">Sequence Viewer (Graphics)</a></dd>
</dl>
</li>
</ol>
<h4 id="mrnaandproteins-p106569312">mRNA and Protein(s) </h4>
<ol>
<li>
<p><a href="/nuccore/NM_001130040.2">NM_001130040.2</a><a href="/protein/NP_001123512.1">NP_001123512.1</a>  SHC-transforming protein 1 isoform 3</p>
<p>
<a href="/ipg/NP_001123512.1/" ref="ncbi_uid=6464">See identical proteins and their annotated locations for NP_001123512.1</a>
</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Description</dt>
<dd>Transcript Variant: This variant (3) encodes the longest isoform (3).</dd>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/BX647149">BX647149</a>
</dd>
<dt>Consensus CDS</dt>
<dd>
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&amp;GO=MainBrowse&amp;DATA=CCDS44233.1">CCDS44233.1</a>
</dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000401303.3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">ENSP00000401303.3</a>, <a href="http://www.ensembl.org/id/ENST00000448116.7" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">ENST00000448116.7</a></dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001123512.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=198179">cd09925</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">481</span><span class="cddto">584</span></dt>
<dd class="clearfix"> SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=269920">cd01209</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">146</span><span class="cddto">317</span></dt>
<dd class="clearfix"> PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/NM_001130041.2">NM_001130041.2</a><a href="/protein/NP_001123513.1">NP_001123513.1</a>  SHC-transforming protein 1 isoform 4</p>
<p>
<a href="/ipg/NP_001123513.1/" ref="ncbi_uid=6464">See identical proteins and their annotated locations for NP_001123513.1</a>
</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Description</dt>
<dd>Transcript Variant: This variant (4) has an alternate 5' sequence and an alternate splice site in the CDS, as compared to variant 3. The resulting isoform (4), also known as p52Shc, has a shorter N-terminus and lacks an internal amino acid, as compared to isoform 3.</dd>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AK292143, BC014158, X68148">AK292143, BC014158, X68148</a>
</dd>
<dt>Consensus CDS</dt>
<dd>
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&amp;GO=MainBrowse&amp;DATA=CCDS44234.1">CCDS44234.1</a>
</dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000357435.1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">ENSP00000357435.1</a>, <a href="http://www.ensembl.org/id/ENST00000368450.5" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">ENST00000368450.5</a></dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001123513.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=198179">cd09925</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">370</span><span class="cddto">473</span></dt>
<dd class="clearfix"> SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=269920">cd01209</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">36</span><span class="cddto">207</span></dt>
<dd class="clearfix"> PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/NM_001202859.2">NM_001202859.2</a><a href="/protein/NP_001189788.1">NP_001189788.1</a>  SHC-transforming protein 1 isoform 5 precursor</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Description</dt>
<dd>Transcript Variant: This variant (5) has an alternate 5' sequence and an alternate splice site in the CDS, as compared to variant 3. The resulting isoform (5), also known as p46Shc, has a shorter N-terminus and lacks an internal amino acid, as compared to isoform 3. Variants 4 and 5 have the same nucleotide sequence, but variant 5 represents use of a downstream AUG compared to variant 4.</dd>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AK292143, BC014158">AK292143, BC014158</a>
</dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/X6R6D0" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">X6R6D0</a>
</dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000357434.4" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">ENSP00000357434.4</a>, <a href="http://www.ensembl.org/id/ENST00000368449.8" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">ENST00000368449.8</a></dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001189788.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=198179">cd09925</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">325</span><span class="cddto">428</span></dt>
<dd class="clearfix"> SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=269920">cd01209</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1</span><span class="cddto">162</span></dt>
<dd class="clearfix"> PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/NM_003029.5">NM_003029.5</a><a href="/protein/NP_003020.2">NP_003020.2</a>  SHC-transforming protein 1 isoform 2</p>
<p>
<a href="/ipg/NP_003020.2/" ref="ncbi_uid=6464">See identical proteins and their annotated locations for NP_003020.2</a>
</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Description</dt>
<dd>Transcript Variant: This variant (2) has an alternate 5' sequence, as compared to variant 3. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 3.</dd>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AK292143, BC014158">AK292143, BC014158</a>
</dd>
<dt>Consensus CDS</dt>
<dd>
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&amp;GO=MainBrowse&amp;DATA=CCDS1076.1">CCDS1076.1</a>
</dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000357438.4" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">ENSP00000357438.4</a>, <a href="http://www.ensembl.org/id/ENST00000368453.8" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">ENST00000368453.8</a></dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_003020.2">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=198179">cd09925</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">371</span><span class="cddto">474</span></dt>
<dd class="clearfix"> SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=269920">cd01209</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">36</span><span class="cddto">207</span></dt>
<dd class="clearfix"> PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/NM_183001.5">NM_183001.5</a><a href="/protein/NP_892113.4">NP_892113.4</a>  SHC-transforming protein 1 isoform 1</p>
<p>
<a href="/ipg/NP_892113.4/" ref="ncbi_uid=6464">See identical proteins and their annotated locations for NP_892113.4</a>
</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Description</dt>
<dd>Transcript Variant: This variant (1) has an alternate splice site in the CDS, as compared to variant 3. The resulting isoform (1), also known as p66Shc, lacks an internal amino acid, as compared to isoform 3.</dd>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/BX647149">BX647149</a>
</dd>
<dt>Consensus CDS</dt>
<dd>
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&amp;GO=MainBrowse&amp;DATA=CCDS30881.1">CCDS30881.1</a>
</dd>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B5BU19" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B5BU19</a>, <a href="https://www.uniprot.org/uniprot/D3DV78" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">D3DV78</a>, <a href="https://www.uniprot.org/uniprot/O15290" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">O15290</a>, <a href="https://www.uniprot.org/uniprot/P29353" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">P29353</a>, <a href="https://www.uniprot.org/uniprot/Q5T180" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">Q5T180</a>, <a href="https://www.uniprot.org/uniprot/Q5T183" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">Q5T183</a>, <a href="https://www.uniprot.org/uniprot/Q5T184" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">Q5T184</a>, <a href="https://www.uniprot.org/uniprot/Q5T185" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">Q5T185</a>, <a href="https://www.uniprot.org/uniprot/Q5T186" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">Q5T186</a>, <a href="https://www.uniprot.org/uniprot/Q8N4K5" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">Q8N4K5</a>, <a href="https://www.uniprot.org/uniprot/Q96CL1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">Q96CL1</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000357430.5" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">ENSP00000357430.5</a>, <a href="http://www.ensembl.org/id/ENST00000368445.9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">ENST00000368445.9</a></dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_892113.4">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=198179">cd09925</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">480</span><span class="cddto">583</span></dt>
<dd class="clearfix"> SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=269920">cd01209</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">146</span><span class="cddto">317</span></dt>
<dd class="clearfix"> PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain</dd>
</dl>
</dd>
</dl>
</li>
</ol>
</div>
<h3 class="genomerefseqs gene_std_toggler" id="annotatedrefseq-title">
<a class="jig-ncbitoggler-open">RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08</a>
</h3>
<div class="genomerefseqs_slave">
<p class="desc"> The following sections contain reference sequences that belong to a
specific genome build. <a href="#" id="expl-genomes">Explain</a></p>
<p id="expl-genomes-desc" style="display:none">This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.</p>
<h3 id="refseq-sequencedescription-p24245664">Reference GRCh38.p14 Primary Assembly</h3>
<h4 id="genomic-p24245664">Genomic </h4>
<ol>
<li>
<p>NC_000001.11 Reference GRCh38.p14 Primary Assembly</p>
<dl>
<dt>Range</dt>
<dd class="rs-range">
<span>154962298..154974376 complement</span>
</dd>
<dt>Download</dt>
<dd><a href="/nuccore/NC_000001.11?from=154962298&amp;to=154974376&amp;report=genbank&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=NC_000001.11?from=154962298&amp;to=154974376&amp;report=genbank&amp;strand=true">GenBank</a>, <a href="/nuccore/NC_000001.11?from=154962298&amp;to=154974376&amp;report=fasta&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=NC_000001.11?from=154962298&amp;to=154974376&amp;report=fasta&amp;strand=true">FASTA</a>, <a href="/nuccore/NC_000001.11?from=154960485&amp;to=154976187&amp;report=graph&amp;content=5&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=NC_000001.11?from=154960485&amp;to=154976187&amp;report=graph&amp;content=5&amp;strand=true">Sequence Viewer (Graphics)</a></dd>
</dl>
</li>
</ol>
<h4 id="mrnaandproteins-p16122848">mRNA and Protein(s) </h4>
<ol>
<li>
<p><a href="/nuccore/XM_017002083.2">XM_017002083.2</a><a href="/protein/XP_016857572.1">XP_016857572.1</a>  SHC-transforming protein 1 isoform X20</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427986.1">XM_047427986.1</a><a href="/protein/XP_047283942.1">XP_047283942.1</a>  SHC-transforming protein 1 isoform X19</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_011509897.2">XM_011509897.2</a><a href="/protein/XP_011508199.1">XP_011508199.1</a>  SHC-transforming protein 1 isoform X18</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_011508199.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=198179">cd09925</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">362</span><span class="cddto">465</span></dt>
<dd class="clearfix"> SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=269920">cd01209</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">36</span><span class="cddto">189</span></dt>
<dd class="clearfix"> PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427994.1">XM_047427994.1</a><a href="/protein/XP_047283950.1">XP_047283950.1</a>  SHC-transforming protein 1 isoform X22</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427991.1">XM_047427991.1</a><a href="/protein/XP_047283947.1">XP_047283947.1</a>  SHC-transforming protein 1 isoform X21</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427972.1">XM_047427972.1</a><a href="/protein/XP_047283928.1">XP_047283928.1</a>  SHC-transforming protein 1 isoform X15</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427970.1">XM_047427970.1</a><a href="/protein/XP_047283926.1">XP_047283926.1</a>  SHC-transforming protein 1 isoform X14</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427989.1">XM_047427989.1</a><a href="/protein/XP_047283945.1">XP_047283945.1</a>  SHC-transforming protein 1 isoform X20</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427988.1">XM_047427988.1</a><a href="/protein/XP_047283944.1">XP_047283944.1</a>  SHC-transforming protein 1 isoform X19</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427995.1">XM_047427995.1</a><a href="/protein/XP_047283951.1">XP_047283951.1</a>  SHC-transforming protein 1 isoform X22</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427982.1">XM_047427982.1</a><a href="/protein/XP_047283938.1">XP_047283938.1</a>  SHC-transforming protein 1 isoform X17</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427992.1">XM_047427992.1</a><a href="/protein/XP_047283948.1">XP_047283948.1</a>  SHC-transforming protein 1 isoform X21</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427974.1">XM_047427974.1</a><a href="/protein/XP_047283930.1">XP_047283930.1</a>  SHC-transforming protein 1 isoform X16</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427973.1">XM_047427973.1</a><a href="/protein/XP_047283929.1">XP_047283929.1</a>  SHC-transforming protein 1 isoform X15</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427971.1">XM_047427971.1</a><a href="/protein/XP_047283927.1">XP_047283927.1</a>  SHC-transforming protein 1 isoform X14</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427959.1">XM_047427959.1</a><a href="/protein/XP_047283915.1">XP_047283915.1</a>  SHC-transforming protein 1 isoform X7</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427958.1">XM_047427958.1</a><a href="/protein/XP_047283914.1">XP_047283914.1</a>  SHC-transforming protein 1 isoform X4</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B5BU19" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B5BU19</a>, <a href="https://www.uniprot.org/uniprot/D3DV78" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">D3DV78</a>, <a href="https://www.uniprot.org/uniprot/O15290" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">O15290</a>, <a href="https://www.uniprot.org/uniprot/P29353" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">P29353</a>, <a href="https://www.uniprot.org/uniprot/Q5T180" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">Q5T180</a>, <a href="https://www.uniprot.org/uniprot/Q5T183" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">Q5T183</a>, <a href="https://www.uniprot.org/uniprot/Q5T184" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">Q5T184</a>, <a href="https://www.uniprot.org/uniprot/Q5T185" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">Q5T185</a>, <a href="https://www.uniprot.org/uniprot/Q5T186" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">Q5T186</a>, <a href="https://www.uniprot.org/uniprot/Q8N4K5" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">Q8N4K5</a>, <a href="https://www.uniprot.org/uniprot/Q96CL1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">Q96CL1</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427984.1">XM_047427984.1</a><a href="/protein/XP_047283940.1">XP_047283940.1</a>  SHC-transforming protein 1 isoform X17</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427993.1">XM_047427993.1</a><a href="/protein/XP_047283949.1">XP_047283949.1</a>  SHC-transforming protein 1 isoform X21</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427978.1">XM_047427978.1</a><a href="/protein/XP_047283934.1">XP_047283934.1</a>  SHC-transforming protein 1 isoform X16</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427983.1">XM_047427983.1</a><a href="/protein/XP_047283939.1">XP_047283939.1</a>  SHC-transforming protein 1 isoform X17</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427975.1">XM_047427975.1</a><a href="/protein/XP_047283931.1">XP_047283931.1</a>  SHC-transforming protein 1 isoform X16</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427964.1">XM_047427964.1</a><a href="/protein/XP_047283920.1">XP_047283920.1</a>  SHC-transforming protein 1 isoform X12</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_017002081.3">XM_017002081.3</a><a href="/protein/XP_016857570.1">XP_016857570.1</a>  SHC-transforming protein 1 isoform X6</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_011509894.4">XM_011509894.4</a><a href="/protein/XP_011508196.1">XP_011508196.1</a>  SHC-transforming protein 1 isoform X5</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_011508196.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=198179">cd09925</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">472</span><span class="cddto">575</span></dt>
<dd class="clearfix"> SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=269920">cd01209</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">146</span><span class="cddto">299</span></dt>
<dd class="clearfix"> PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427963.1">XM_047427963.1</a><a href="/protein/XP_047283919.1">XP_047283919.1</a>  SHC-transforming protein 1 isoform X11</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427962.1">XM_047427962.1</a><a href="/protein/XP_047283918.1">XP_047283918.1</a>  SHC-transforming protein 1 isoform X10</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427961.1">XM_047427961.1</a><a href="/protein/XP_047283917.1">XP_047283917.1</a>  SHC-transforming protein 1 isoform X9</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_011509893.4">XM_011509893.4</a><a href="/protein/XP_011508195.1">XP_011508195.1</a>  SHC-transforming protein 1 isoform X3</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_011508195.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=198179">cd09925</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">489</span><span class="cddto">592</span></dt>
<dd class="clearfix"> SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=269920">cd01209</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">146</span><span class="cddto">317</span></dt>
<dd class="clearfix"> PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427960.1">XM_047427960.1</a><a href="/protein/XP_047283916.1">XP_047283916.1</a>  SHC-transforming protein 1 isoform X8</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_011509892.4">XM_011509892.4</a><a href="/protein/XP_011508194.1">XP_011508194.1</a>  SHC-transforming protein 1 isoform X2</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_011508194.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=198179">cd09925</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">490</span><span class="cddto">593</span></dt>
<dd class="clearfix"> SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=269920">cd01209</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">146</span><span class="cddto">317</span></dt>
<dd class="clearfix"> PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_005245449.6">XM_005245449.6</a><a href="/protein/XP_005245506.1">XP_005245506.1</a>  SHC-transforming protein 1 isoform X1</p>
<dl>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_005245506.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=198179">cd09925</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">480</span><span class="cddto">583</span></dt>
<dd class="clearfix"> SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=269920">cd01209</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">146</span><span class="cddto">317</span></dt>
<dd class="clearfix"> PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_011509898.3">XM_011509898.3</a><a href="/protein/XP_011508200.1">XP_011508200.1</a>  SHC-transforming protein 1 isoform X23</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/Q59HB0" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">Q59HB0</a>
</dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_011508200.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=198179">cd09925</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">314</span><span class="cddto">417</span></dt>
<dd class="clearfix"> SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=269920">cd01209</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1</span><span class="cddto">151</span></dt>
<dd class="clearfix"> PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_005245451.5">XM_005245451.5</a><a href="/protein/XP_005245508.1">XP_005245508.1</a>  SHC-transforming protein 1 isoform X13</p>
<p>
<a href="/ipg/XP_005245508.1/" ref="ncbi_uid=6464">See identical proteins and their annotated locations for XP_005245508.1</a>
</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_005245508.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=198179">cd09925</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">370</span><span class="cddto">473</span></dt>
<dd class="clearfix"> SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=269920">cd01209</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">36</span><span class="cddto">207</span></dt>
<dd class="clearfix"> PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427967.1">XM_047427967.1</a><a href="/protein/XP_047283923.1">XP_047283923.1</a>  SHC-transforming protein 1 isoform X13</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427969.1">XM_047427969.1</a><a href="/protein/XP_047283925.1">XP_047283925.1</a>  SHC-transforming protein 1 isoform X13</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047427968.1">XM_047427968.1</a><a href="/protein/XP_047283924.1">XP_047283924.1</a>  SHC-transforming protein 1 isoform X13</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
</ol>
<h3 id="refseq-sequencedescription-p67175600">Alternate T2T-CHM13v2.0</h3>
<h4 id="genomic-p67175600">Genomic </h4>
<ol>
<li>
<p>NC_060925.1 Alternate T2T-CHM13v2.0</p>
<dl>
<dt>Range</dt>
<dd class="rs-range">
<span>154101659..154113737 complement</span>
</dd>
<dt>Download</dt>
<dd><a href="/nuccore/NC_060925.1?from=154101659&amp;to=154113737&amp;report=genbank&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=NC_060925.1?from=154101659&amp;to=154113737&amp;report=genbank&amp;strand=true">GenBank</a>, <a href="/nuccore/NC_060925.1?from=154101659&amp;to=154113737&amp;report=fasta&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=NC_060925.1?from=154101659&amp;to=154113737&amp;report=fasta&amp;strand=true">FASTA</a>, <a href="/nuccore/NC_060925.1?from=154099846&amp;to=154115548&amp;report=graph&amp;content=5&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=NC_060925.1?from=154099846&amp;to=154115548&amp;report=graph&amp;content=5&amp;strand=true">Sequence Viewer (Graphics)</a></dd>
</dl>
</li>
</ol>
<h4 id="mrnaandproteins-p93794976">mRNA and Protein(s) </h4>
<ol>
<li>
<p><a href="/nuccore/XM_054338246.1">XM_054338246.1</a><a href="/protein/XP_054194221.1">XP_054194221.1</a>  SHC-transforming protein 1 isoform X20</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338244.1">XM_054338244.1</a><a href="/protein/XP_054194219.1">XP_054194219.1</a>  SHC-transforming protein 1 isoform X19</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338243.1">XM_054338243.1</a><a href="/protein/XP_054194218.1">XP_054194218.1</a>  SHC-transforming protein 1 isoform X18</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338251.1">XM_054338251.1</a><a href="/protein/XP_054194226.1">XP_054194226.1</a>  SHC-transforming protein 1 isoform X22</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338248.1">XM_054338248.1</a><a href="/protein/XP_054194223.1">XP_054194223.1</a>  SHC-transforming protein 1 isoform X21</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338235.1">XM_054338235.1</a><a href="/protein/XP_054194210.1">XP_054194210.1</a>  SHC-transforming protein 1 isoform X15</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338233.1">XM_054338233.1</a><a href="/protein/XP_054194208.1">XP_054194208.1</a>  SHC-transforming protein 1 isoform X14</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338247.1">XM_054338247.1</a><a href="/protein/XP_054194222.1">XP_054194222.1</a>  SHC-transforming protein 1 isoform X20</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338245.1">XM_054338245.1</a><a href="/protein/XP_054194220.1">XP_054194220.1</a>  SHC-transforming protein 1 isoform X19</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338252.1">XM_054338252.1</a><a href="/protein/XP_054194227.1">XP_054194227.1</a>  SHC-transforming protein 1 isoform X22</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338240.1">XM_054338240.1</a><a href="/protein/XP_054194215.1">XP_054194215.1</a>  SHC-transforming protein 1 isoform X17</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338249.1">XM_054338249.1</a><a href="/protein/XP_054194224.1">XP_054194224.1</a>  SHC-transforming protein 1 isoform X21</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338237.1">XM_054338237.1</a><a href="/protein/XP_054194212.1">XP_054194212.1</a>  SHC-transforming protein 1 isoform X16</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338236.1">XM_054338236.1</a><a href="/protein/XP_054194211.1">XP_054194211.1</a>  SHC-transforming protein 1 isoform X15</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338234.1">XM_054338234.1</a><a href="/protein/XP_054194209.1">XP_054194209.1</a>  SHC-transforming protein 1 isoform X14</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338223.1">XM_054338223.1</a><a href="/protein/XP_054194198.1">XP_054194198.1</a>  SHC-transforming protein 1 isoform X7</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338220.1">XM_054338220.1</a><a href="/protein/XP_054194195.1">XP_054194195.1</a>  SHC-transforming protein 1 isoform X4</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B5BU19" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B5BU19</a>, <a href="https://www.uniprot.org/uniprot/D3DV78" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">D3DV78</a>, <a href="https://www.uniprot.org/uniprot/O15290" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">O15290</a>, <a href="https://www.uniprot.org/uniprot/P29353" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">P29353</a>, <a href="https://www.uniprot.org/uniprot/Q5T180" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">Q5T180</a>, <a href="https://www.uniprot.org/uniprot/Q5T183" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">Q5T183</a>, <a href="https://www.uniprot.org/uniprot/Q5T184" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">Q5T184</a>, <a href="https://www.uniprot.org/uniprot/Q5T185" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">Q5T185</a>, <a href="https://www.uniprot.org/uniprot/Q5T186" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">Q5T186</a>, <a href="https://www.uniprot.org/uniprot/Q8N4K5" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">Q8N4K5</a>, <a href="https://www.uniprot.org/uniprot/Q96CL1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">Q96CL1</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338242.1">XM_054338242.1</a><a href="/protein/XP_054194217.1">XP_054194217.1</a>  SHC-transforming protein 1 isoform X17</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338250.1">XM_054338250.1</a><a href="/protein/XP_054194225.1">XP_054194225.1</a>  SHC-transforming protein 1 isoform X21</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338239.1">XM_054338239.1</a><a href="/protein/XP_054194214.1">XP_054194214.1</a>  SHC-transforming protein 1 isoform X16</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338241.1">XM_054338241.1</a><a href="/protein/XP_054194216.1">XP_054194216.1</a>  SHC-transforming protein 1 isoform X17</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338238.1">XM_054338238.1</a><a href="/protein/XP_054194213.1">XP_054194213.1</a>  SHC-transforming protein 1 isoform X16</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338228.1">XM_054338228.1</a><a href="/protein/XP_054194203.1">XP_054194203.1</a>  SHC-transforming protein 1 isoform X12</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338222.1">XM_054338222.1</a><a href="/protein/XP_054194197.1">XP_054194197.1</a>  SHC-transforming protein 1 isoform X6</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338221.1">XM_054338221.1</a><a href="/protein/XP_054194196.1">XP_054194196.1</a>  SHC-transforming protein 1 isoform X5</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338227.1">XM_054338227.1</a><a href="/protein/XP_054194202.1">XP_054194202.1</a>  SHC-transforming protein 1 isoform X11</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338226.1">XM_054338226.1</a><a href="/protein/XP_054194201.1">XP_054194201.1</a>  SHC-transforming protein 1 isoform X10</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338225.1">XM_054338225.1</a><a href="/protein/XP_054194200.1">XP_054194200.1</a>  SHC-transforming protein 1 isoform X9</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338219.1">XM_054338219.1</a><a href="/protein/XP_054194194.1">XP_054194194.1</a>  SHC-transforming protein 1 isoform X3</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338224.1">XM_054338224.1</a><a href="/protein/XP_054194199.1">XP_054194199.1</a>  SHC-transforming protein 1 isoform X8</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338218.1">XM_054338218.1</a><a href="/protein/XP_054194193.1">XP_054194193.1</a>  SHC-transforming protein 1 isoform X2</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338217.1">XM_054338217.1</a><a href="/protein/XP_054194192.1">XP_054194192.1</a>  SHC-transforming protein 1 isoform X1</p>
<dl></dl>
</li>
<li>
<p><a href="/nuccore/XM_054338253.1">XM_054338253.1</a><a href="/protein/XP_054194228.1">XP_054194228.1</a>  SHC-transforming protein 1 isoform X23</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/Q59HB0" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">Q59HB0</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338229.1">XM_054338229.1</a><a href="/protein/XP_054194204.1">XP_054194204.1</a>  SHC-transforming protein 1 isoform X13</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338230.1">XM_054338230.1</a><a href="/protein/XP_054194205.1">XP_054194205.1</a>  SHC-transforming protein 1 isoform X13</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338232.1">XM_054338232.1</a><a href="/protein/XP_054194207.1">XP_054194207.1</a>  SHC-transforming protein 1 isoform X13</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054338231.1">XM_054338231.1</a><a href="/protein/XP_054194206.1">XP_054194206.1</a>  SHC-transforming protein 1 isoform X13</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B4DL02" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=6464&amp;nlmid=&amp;db=gene">B4DL02</a>
</dd>
</dl>
</li>
</ol>
</div>
</div>
</div>
<div class="rprt-section gene-related-sequences">
<section class="rprt-section-header" id="related-sequences">
<h2 id="header-related-sequences">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-related-sequences .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Related sequences</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Related_Sequences" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<table id="proteinTblId" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/6464/data/related-sequences/',webserviceParams: 'p$l=Ajax', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
<thead>
<tr>
<th colspan="2" id="rs-nucleo">Nucleotide</th>
<th rowspan="2" id="rs-protein">Protein</th>
</tr>
<tr>
<th id="rs-heading">Heading</th>
<th id="rs-heading-acc">Accession and Version</th>
</tr>
</thead>
<tbody></tbody>
</table>
<table id="proteinTblId" class="jig-ncbigrid" data-jigconfig="isPageable:true, pageSize:25">
<thead>
<tr>
<th class="proteinTblTh" rowspan="2" id="rs-prot-acc">Protein Accession</th>
<th class="proteinTblTh" colspan="2" id="rs-link">Links</th>
</tr>
<tr>
<th id="rs-genepept">GenPept Link</th>
<th id="rs-uniprot">UniProtKB Link</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="rs-prot-acc">P29353.4</td>
<td headers="rs-link rs-genepept">
<a href="/protein/182676455" ref="ordinalpos=1&amp;ncbi_uid=6464&amp;link_uid=182676455">GenPept</a>
</td>
<td>
<a href="https://www.uniprot.org/uniprot/P29353">UniProtKB/Swiss-Prot:P29353</a>
</td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<div class="rprt-section gene-additional-links">
<section class="rprt-section-header" id="additional-links"><h2 id="header-additional-links"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-additional-links .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Additional links</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Additional_Links" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
<div class="rprt-section-body" style="">
<h3 class="withnote" id="genelinkout">
<a class="jig-ncbitoggler">Gene LinkOut</a>
</h3><div>
<p>The following <a href="https://www.ncbi.nlm.nih.gov/projects/linkout/index.html">LinkOut</a> resources are supplied by external providers. These providers are responsible for maintaining the links. </p>
<div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Chemical Information</span>
</a>
<ul>
<li><span class="free-rsc"></span>Interologous Interaction Database</li>
<ul>
<li>
<a target="_blank" href="http://ophid.utoronto.ca/redirect/ncbi/human?proteins=6464" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7911">
<span>Interologous Interaction Database</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>MilliporeSigma</li>
<ul>
<li>
<a target="_blank" href="https://www.sigmaaldrich.com/catalog/genes/SHC1?lang=en&amp;region=US" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9978">
<span>SHC1 products</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Molecular Biology Databases</span>
</a>
<ul>
<li><span class="free-rsc"></span>Bgee database</li>
<ul>
<li>
<a target="_blank" href="https://www.bgee.org/gene/ENSG00000160691" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10418">
<span>SHC1 gene expression</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>BioGPS</li>
<ul>
<li>
<a target="_blank" href="http://biogps.org/gene/6464/" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5059">
<span>BioGPS</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>BioGRID Open Repository of CRISPR Screens (ORCS)</li>
<ul>
<li>
<a target="_blank" href="https://orcs.thebiogrid.org/Gene/6464" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10164">
<span>BioGRID CRISPR Screen Phenotypes (58 hits/1369 screens)</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Domain Mapping of Disease Mutations</li>
<ul>
<li>
<a target="_blank" href="http://bioinf.umbc.edu/DMDM/gene_prot_page.php?id=6464" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7642">
<span>SHC1</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Eukaryotic Promoter Database</li>
<ul>
<li>
<a target="_blank" href="http://epd.vital-it.ch/cgi-bin/get_doc?db=hgEpdNew&amp;format=genome&amp;entry=SHC1_1" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9624">
<span>SHC1_1</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>GenAge Database of Aging Related Genes</li>
<ul>
<li>
<a target="_blank" href="http://genomics.senescence.info/genes/entry.php?hgnc=SHC1" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=6827">
<span>GenAge Database of Aging Related Genes</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>GlyGen glycoinformatics resource</li>
<ul>
<li>
<a target="_blank" href="https://glygen.org/protein/P29353" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10227">
<span>GlyGen glycoinformatics resource</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Human eFP Browser</li>
<ul>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Nervous&amp;modeInput=Absolute&amp;primaryGene=6464" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Skeletal_Immune_Digestive&amp;modeInput=Absolute&amp;primaryGene=6464" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Circulatory_Respiratory&amp;modeInput=Absolute&amp;primaryGene=6464" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
</ul>
<li>Ingenuity Pathways Analysis</li>
<ul>
<li>
<a target="_blank" href="http://partnersolution.ingenuity.com/?cid=97ae3f91eab87a&amp;p1=Entrez&amp;p2=GV&amp;s=&amp;ipaUri=%2Fpa%2Fapi%2Fv2%2Fgeneview%3Fapplicationname%3DEntrez%26geneId%3D6464%26geneidtype%3Dentrezgene" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5628">
<span>Ingenuity Pathways Analysis</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>InnateDB</li>
<ul>
<li>
<a target="_blank" href="http://www.innatedb.com/getGeneCard.do?id=103007" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7894">
<span>InnateDB</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>InterMine</li>
<ul>
<li>
<a target="_blank" href="https://www.humanmine.org/humanmine/search?keyword=ENSG00000160691" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9169">
<span>InterMine</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Kyoto Encyclopedia of Genes and Genomes</li>
<ul>
<li>
<a target="_blank" href="http://www.genome.jp/dbget-bin/www_bget?hsa:6464" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5174">
<span>Kyoto Encyclopedia of Genes and Genomes</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>OMA Browser: Orthologous MAtrix</li>
<ul>
<li>
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN52424/" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9822">
<span>OMA Browser: Orthologous MAtrix</span>
</a>
</li>
<li>
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN52425/" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9822">
<span>OMA Browser: Orthologous MAtrix</span>
</a>
</li>
<li>
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN52422/" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9822">
<span>OMA Browser: Orthologous MAtrix</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>OrthoDB catalog of orthologs</li>
<ul>
<li>
<a target="_blank" href="https://www.orthodb.org/?ncbi=6464" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8178">
<span>Orthologs</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Pharmacogenomics Knowledge Base</li>
<ul>
<li>
<a target="_blank" href="https://www.pharmgkb.org/gene/PA35746" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=4067">
<span>Annotated Pharmacogenomic Information for SHC1 [PharmGKB]</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>PhosphoSitePlus</li>
<ul>
<li>
<a target="_blank" href="https://www.phosphosite.org/entrezGeneIdAction.action?id=6464" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7987">
<span>PhosphoSitePlus® - comprehensive post-translational modification resource</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>The Gene Wiki</li>
<ul>
<li>
<a target="_blank" href="https://en.wikipedia.org/wiki/SHC1" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=6933">
<span>The Gene Wiki</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>The Weizmann Institute of Science GeneCards and MalaCards databases</li>
<ul>
<li>
<a target="_blank" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=SHC1" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8598">
<span>GeneCard for SHC1</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Research Materials</span>
</a>
<ul>
<li><span class="order-rsc"></span>Addgene Non-profit plasmid repository</li>
<ul>
<li>
<a target="_blank" href="https://addgene.org//browse/gene/6464" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5304">
<span>Get Plasmids - Addgene</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>Bio-Techne</li>
<ul>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/shc1/proteins-enzymes?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=proteins" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>SHC1 Proteins</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/shc1/antibodies?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=antibodies" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>SHC1 Antibodies</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/shc1/lysates?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=lysates" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>SHC1 Lysates</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>Creative Biogene</li>
<ul>
<li>
<a target="_blank" href="https://www.creative-biogene.com/genesearch/Shc1.html" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10094">
<span>SHC (Src homology 2 domain containing) transforming protein 1</span>
</a>
</li>
</ul>
<li>ExactAntigen/Labome</li>
<ul>
<li>
<a target="_blank" href="https://www.labome.com/gene/human/Shc-antibody.html" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5753">
<span>reagents</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.labome.com/review/gene/human/Shc-antibody.html" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5753">
<span>reagent review</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GenScript latest version of gene cDNA ORF Clone</li>
<ul>
<li>
<a target="_blank" href="http://www.genscript.com/gene/6464" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8012">
<span>GenScript latest version of gene cDNA ORF Clone</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GeneCopoeia Inc.</li>
<ul>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=26&amp;field=5&amp;key=6464" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order TALEN/CRISPR clones</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?tax_id=9606&amp;field=5&amp;prt=16&amp;key=6464" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order miRNA target clones</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=1&amp;field=5&amp;key=6464" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order full-length ORF clone</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GeneTex Inc</li>
<ul>
<li>
<a target="_blank" href="https://www.genetex.com/Product/Search?geneid=6464&amp;type=03&amp;page=1" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8117">
<span>Find Recombinant Proteins and Peptides</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.genetex.com/Product/Search?geneid=6464&amp;type=01&amp;page=1" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8117">
<span>Find Quality Antibodies</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>Kazusa DNA Research Institute</li>
<ul>
<li>
<a target="_blank" href="http://www.kazusa.or.jp/kop/dsearch/symsearch.cgi?keyword=SHC1;" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=3267">
<span>Kazusa DNA Research Institute</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>OriGene</li>
<ul>
<li>
<a target="_blank" href="https://www.origene.com/search?q=SHC1" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7994">
<span>Order SHC1 cDNA clone/Protein/Antibody/RNAi</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Tools</span>
</a>
<ul>
<li><span class="free-rsc"></span>GeneMANIA</li>
<ul>
<li>
<a target="_blank" href="http://genemania.org/link?o=9606&amp;g=6464" ref="itool=Gene_FullReport&amp;uid=6464&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7529">
<span>GeneMANIA</span>
</a>
</li>
</ul>
</ul>
</div>
</div>
</div>
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</div>
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</div>
</div>
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<!-- sidebar close/hide button-->
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<h2 class="offscreen_noflow">Supplemental Content</h2>
<div id="gene-sidebar">
<div>
<div class="portlet brieflink dis-table-of-contents">
<div class="portlet_head">
<div class="portlet_title">
<h3>Table of contents</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_TableOfContents" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li class="">
<a href="#summary">Summary</a>
</li>
<li class="">
<a href="#genomic-context">Genomic context</a>
</li>
<li class="">
<a href="#genomic-regions-transcripts-products">Genomic regions, transcripts, and products</a>
</li>
<li class="">
<a href="#gene-expression">Expression</a>
</li>
<li class="">
<a href="#bibliography">Bibliography</a>
</li>
<li class="">
<a href="#phenotypes">Phenotypes</a>
</li>
<li class="">
<a href="#variation">Variation</a>
</li>
<li class="">
<a href="#HIV-1-interactions">HIV-1 interactions</a>
</li>
<li class="">
<a href="#pathways">Pathways from PubChem</a>
</li>
<li class="">
<a href="#interactions">Interactions</a>
</li>
<li class="">
<a href="#general-gene-info">General gene information</a>
<div class="subsection-links"><a href="#gene-markers">Markers</a>, <a href="#Relatedpseudogenes">Related pseudogene(s)</a>, <a href="#CloneNames">Clone Names</a>, <a href="#homology">Homology</a>, <a href="#gene-ontology">Gene Ontology</a></div>
</li>
<li class="">
<a href="#general-protein-info">General protein information</a>
</li>
<li class="">
<a href="#reference-sequences">NCBI Reference Sequences (RefSeq)</a>
</li>
<li class="">
<a href="#related-sequences">Related sequences</a>
</li>
<li class="">
<a href="#additional-links">Additional links</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-genomesbrowser brieflink dis-genomesbrowser">
<div class="portlet_head">
<div class="portlet_title">
<h3>Genome Browsers</h3>
</div>
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<li>
<a href="#">Loading...</a>
</li>
</ul>
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</div>
<div class="portlet dis-related-info brieflink">
<div class="portlet_head">
<div class="portlet_title">
<h3>Related information</h3>
</div>
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</div>
<div class="portlet_content DiscoveryDbLinks">
<ul>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clone/order/gene/6464" ref="log$=recordlinks">Order cDNA clone</a>
<div class="brieflinkpop offscreen_noflow">Order cDNA clone</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/structure?LinkName=gene_structure&amp;from_uid=6464" ref="log$=recordlinks">3D structures</a>
<div class="brieflinkpop offscreen_noflow">3D structure of a gene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_alltarget_list&amp;from_uid=6464" ref="log$=recordlinks">BioAssay by Target (List)</a>
<div class="brieflinkpop offscreen_noflow">BioAssays related to the gene by protein target or RNAi target</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="//pubchem.ncbi.nlm.nih.gov/assay/bioactivity.html?geneid=6464" ref="log$=recordlinks">BioAssay by Target (Summary)</a>
<div class="brieflinkpop offscreen_noflow">Summarized PubChem Data on the gene, showing the active data by default</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_target&amp;from_uid=6464" ref="log$=recordlinks">BioAssay, by Gene target</a>
<div class="brieflinkpop offscreen_noflow">PubChem BioAssays done on the Gene target</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai_active&amp;from_uid=6464" ref="log$=recordlinks">BioAssays, RNAi Target, Active</a>
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent, which is identified as a hit in a RNAi screening and flagged as "active" in the corresponding BioAssay record</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai&amp;from_uid=6464" ref="log$=recordlinks">BioAssays, RNAi Target, Tested</a>
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/bioproject?LinkName=gene_bioproject&amp;from_uid=6464" ref="log$=recordlinks">BioProjects</a>
<div class="brieflinkpop offscreen_noflow">BioProjects related to a gene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/biosystems?LinkName=gene_biosystems&amp;from_uid=6464" ref="log$=recordlinks">BioSystems</a>
<div class="brieflinkpop offscreen_noflow">BioSystems</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/CCDS/CcdsBrowse.cgi?REQUEST=GENEID&amp;DATA=6464" ref="log$=recordlinks">CCDS</a>
<div class="brieflinkpop offscreen_noflow">Link to CCDS</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar&amp;from_uid=6464" ref="log$=recordlinks">ClinVar</a>
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/cdd?LinkName=gene_cdd&amp;from_uid=6464" ref="log$=recordlinks">Conserved Domains</a>
<div class="brieflinkpop offscreen_noflow">Related CDD</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/dbvar?LinkName=gene_dbvar&amp;from_uid=6464" ref="log$=recordlinks">dbVar</a>
<div class="brieflinkpop offscreen_noflow">Link from Gene to dbVar</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc&amp;from_uid=6464" ref="log$=recordlinks">Full text in PMC</a>
<div class="brieflinkpop offscreen_noflow">PMC links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc_nucleotide&amp;from_uid=6464" ref="log$=recordlinks">Full text in PMC_nucleotide</a>
<div class="brieflinkpop offscreen_noflow">Full text in PubMedCentral identified from shared sequence links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/sparcle?LinkName=gene_sparcle&amp;from_uid=6464" ref="log$=recordlinks">Functional Class</a>
<div class="brieflinkpop offscreen_noflow">Functional class of the sequence domain architecture</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gap?LinkName=gene_gap&amp;from_uid=6464" ref="log$=recordlinks">GAP</a>
<div class="brieflinkpop offscreen_noflow">GAP Links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gene?LinkName=gene_gene_neighbors&amp;from_uid=6464" ref="log$=recordlinks">Gene neighbors</a>
<div class="brieflinkpop offscreen_noflow">Overlapping genes and two nearest non-overlapping genes on either side</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gene?LinkName=gene_gene_h3k4me3&amp;from_uid=6464" ref="log$=recordlinks">Genes with a similar H3K4me3 profile</a>
<div class="brieflinkpop offscreen_noflow">Genes with a similar profile of promoter-activating H3K4me3 modifications across several tissue types</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/genome?LinkName=gene_genome&amp;from_uid=6464" ref="log$=recordlinks">Genome</a>
<div class="brieflinkpop offscreen_noflow">Related Genome</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/geoprofiles?LinkName=gene_geoprofiles&amp;from_uid=6464" ref="log$=recordlinks">GEO Profiles</a>
<div class="brieflinkpop offscreen_noflow">Related GEO</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gtr/tests/?term=6464[geneid]" ref="log$=recordlinks">GTR</a>
<div class="brieflinkpop offscreen_noflow">Tests for this gene in the NIH Genetic Testing Registry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/homologene?LinkName=gene_homologene&amp;from_uid=6464" ref="log$=recordlinks">HomoloGene</a>
<div class="brieflinkpop offscreen_noflow">Related HomoloGene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore&amp;from_uid=6464" ref="log$=recordlinks">Nucleotide</a>
<div class="brieflinkpop offscreen_noflow">Link to related Nucleotide entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/omim?LinkName=gene_omim&amp;from_uid=6464" ref="log$=recordlinks">OMIM</a>
<div class="brieflinkpop offscreen_noflow">Link to related OMIM entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/probe?LinkName=gene_probe&amp;from_uid=6464" ref="log$=recordlinks">Probe</a>
<div class="brieflinkpop offscreen_noflow">Related Probe entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein&amp;from_uid=6464" ref="log$=recordlinks">Protein</a>
<div class="brieflinkpop offscreen_noflow">Link to related protein entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pccompound?LinkName=gene_pccompound&amp;from_uid=6464" ref="log$=recordlinks">PubChem Compound</a>
<div class="brieflinkpop offscreen_noflow">PubChem Compounds</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcsubstance?LinkName=gene_pcsubstance&amp;from_uid=6464" ref="log$=recordlinks">PubChem Substance</a>
<div class="brieflinkpop offscreen_noflow">PubChem Substances</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed&amp;from_uid=6464" ref="log$=recordlinks">PubMed</a>
<div class="brieflinkpop offscreen_noflow">Link to related PubMed entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_rif&amp;from_uid=6464" ref="log$=recordlinks">PubMed (GeneRIF)</a>
<div class="brieflinkpop offscreen_noflow">Link to related PubMed article from GeneRIFs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_citedinomim&amp;from_uid=6464" ref="log$=recordlinks">PubMed (OMIM)</a>
<div class="brieflinkpop offscreen_noflow">Gene links to PubMed derived from omim_pubmed_cited links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_pmc_nucleotide&amp;from_uid=6464" ref="log$=recordlinks">PubMed(nucleotide/PMC)</a>
<div class="brieflinkpop offscreen_noflow">Citations in PubMed identified from shared sequence and PMC links.</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein_refseq&amp;from_uid=6464" ref="log$=recordlinks">RefSeq Proteins</a>
<div class="brieflinkpop offscreen_noflow">Link to Protein RefSeqs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore_refseqrna&amp;from_uid=6464" ref="log$=recordlinks">RefSeq RNAs</a>
<div class="brieflinkpop offscreen_noflow">Link to Nucleotide RefSeq RNAs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/nuccore/334358872?report=graph" ref="log$=recordlinks">RefSeqGene</a>
<div class="brieflinkpop offscreen_noflow">Link to Nucleotide RefSeqGenes</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/snp?LinkName=gene_snp&amp;from_uid=6464" ref="log$=recordlinks">SNP</a>
<div class="brieflinkpop offscreen_noflow">Related SNP records</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/taxonomy?LinkName=gene_taxonomy&amp;from_uid=6464" ref="log$=recordlinks">Taxonomy</a>
<div class="brieflinkpop offscreen_noflow">Link to related taxonomy entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/variation/view/?q=6464[geneid]" ref="log$=recordlinks">Variation Viewer</a>
<div class="brieflinkpop offscreen_noflow">Related Variants</div>
</li>
</ul>
</div>
</div>
<div class="portlet dis-links-to-other-res brieflink">
<div class="portlet_head">
<div class="portlet_title">
<h3>Links to other resources</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_LinksTwo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10840">HGNC</a>
</li>
<li>
<a href="http://www.ensembl.org/id/ENSG00000160691">Ensembl</a>
</li>
<li>
<a href="https://www.alliancegenome.org/gene/HGNC:10840">AllianceGenome</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=geneid&amp;org=9606&amp;l=6464">AceView</a>
</li>
<li>
<a href="http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&amp;position=NM_001130040">UCSC</a>
</li>
<li>
<a href="https://genecollections.nci.nih.gov/MGC/?ORG=Hs&amp;LIST=BC014158,BC033925">MGC</a>
</li>
<li>
<a href="https://phgkb.cdc.gov/PHGKB/huGEPedia.action?firstQuery=SHC1&amp;geneID=6464&amp;typeOption=gene&amp;which=2&amp;pubOrderType=pubD&amp;typeSubmit=GO&amp;check=y">HuGE Navigator</a>
</li>
<li>
<a href="http://www.genome.jp/dbget-bin/www_bget?hsa:6464">KEGG</a>
</li>
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<a href="/pmc/?term=PMC4383897+OR+PMC3013746+OR+PMC1761442+OR+PMC539985">About Gene</a>
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<li>
<a href="/books/NBK3840">FAQ</a>
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<a href="https://ftp.ncbi.nlm.nih.gov/gene/">FTP site</a>
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<a href="/books/NBK3841/">Help</a>
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<a href="/books/NBK3842/">My NCBI help</a>
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<li>
<a href="/books/NBK21085/">NCBI Handbook</a>
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<li>
<a href="/gene/statistics/">Statistics</a>
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<a href="https://www.ncbi.nlm.nih.gov/BLAST">BLAST</a>
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<a href="https://www.ncbi.nlm.nih.gov/genome">Genome</a>
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<a href="https://www.ncbi.nlm.nih.gov/bioproject">BioProject</a>
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<a href="https://www.ncbi.nlm.nih.gov/genome/gdv/">Genome Data Viewer</a>
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<a href="https://www.ncbi.nlm.nih.gov/probe">Probe</a>
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<a href="https://www.ncbi.nlm.nih.gov/RefSeq">RefSeq</a>
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<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67c9fd3ff4a390645ee3f4dd">SHC1 SHC adaptor protein 1 [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">SHC1 SHC adaptor protein 1 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:6464</div></div>
<div class="tertiary">Gene</div>
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<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67c9fd3db15b832ebcb37daf">SHC-transforming protein 1 isoform 2 [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">SHC-transforming protein 1 isoform 2 [Homo sapiens]<div class="brieflinkpopdesc">gi|32261324|ref|NP_003020.2|</div></div>
<div class="tertiary">Protein</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67c9fd3cf4a390645ee3dd95">SH3BGRL2 SH3 domain binding glutamate rich protein like 2 [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">SH3BGRL2 SH3 domain binding glutamate rich protein like 2 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:83699</div></div>
<div class="tertiary">Gene</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67c9fd3a84f3725e59e132ca">SH3 domain-binding glutamic acid-rich-like protein 2 [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">SH3 domain-binding glutamic acid-rich-like protein 2 [Homo sapiens]<div class="brieflinkpopdesc">gi|13899317|ref|NP_113657.1|</div></div>
<div class="tertiary">Protein</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67c9fd3884f3725e59e12b76">SGK1 serum/glucocorticoid regulated kinase 1 [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">SGK1 serum/glucocorticoid regulated kinase 1 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:6446</div></div>
<div class="tertiary">Gene</div>
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<p class="address_footer text-white">National Library of Medicine<br />
<a href="https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/@38.9959508,-77.101021,17z/data=!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb:0x19156f88b27635b8!8m2!3d38.9959508!4d-77.0988323" class="text-white" target="_blank" rel="noopener noreferrer">8600 Rockville Pike<br />
Bethesda, MD 20894</a></p>
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<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
<a href="https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office" class="text-white">FOIA</a><br />
<a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" class="text-white" id="vdp">HHS Vulnerability Disclosure</a></p>
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<p><a class="supportLink text-white" href="https://support.nlm.nih.gov/">Help</a><br />
<a href="https://www.nlm.nih.gov/accessibility.html" class="text-white">Accessibility</a><br />
<a href="https://www.nlm.nih.gov/careers/careers.html" class="text-white">Careers</a></p>
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<nav class="bottom-links">
<ul class="mt-3">
<li>
<a class="text-white" href="//www.nlm.nih.gov/">NLM</a>
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<a class="text-white" href="https://www.nih.gov/">NIH</a>
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<li>
<a class="text-white" href="https://www.hhs.gov/">HHS</a>
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<li>
<a class="text-white" href="https://www.usa.gov/">USA.gov</a>
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</nav>
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