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<title>MT-TK mitochondrially encoded tRNA lysine [Homo sapiens (human)] - Gene - NCBI</title>
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<div class="search"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="pubmed">PubMed</option><option value="books">Books</option><option value="medgen">MedGen</option><option value="clinvar" class="last">ClinVar</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly" data-ac_dict="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene" selected="selected" data-ac_dict="gene">Gene</option><option value="genome" data-ac_dict="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen">MedGen</option><option value="mesh">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore" data-ac_dict="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein" data-ac_dict="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search Gene. Use up and down arrows to choose an item from the autocomplete." value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="dictionary:'gene',disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'yes',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div><ul class="searchlinks inline_list"><set></set><li><a href="/gene/advanced">Advanced</a></li><li class="help"><a id="help" class="jig-ncbihelpwindow" target="ncbihelp" name="help" href="/books/NBK3841/">Help</a></li></ul></div>
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<div class="facet_cont" data-db="gene" data-default_grps="fg_gene-sources,fg_categories,fg_sequence-content,fg_status" data-sd="db:'gene',op:'select',term:'',qk:'28373',linkname:'',idsfromresult:'4566',extra:''"><ul class="facet" data-filter_id="gene-sources" id="_gene-sources"><li class="filter_grp "><div class="clearfix"><h3>Gene sources</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="mitochondria">Mitochondria</a></li><li class="fil_val"><a href="#" data-value_id="organelles">Organelles</a></li></ul></li></ul><ul class="facet" data-filter_id="categories" id="_categories"><li class="filter_grp "><div class="clearfix"><h3>Categories</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="annotated-genes">Annotated genes</a></li><li class="fil_val"><a href="#" data-value_id="non-coding">Non-coding</a></li></ul></li></ul><ul class="facet" data-filter_id="sequence-content" id="_sequence-content"><li class="filter_grp "><div class="clearfix"><h3>Sequence content</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="seq-ensembl">Ensembl</a></li></ul></li></ul><ul class="facet" data-filter_id="status" id="_status"><li class="filter_grp "><div class="clearfix"><h3>Status</h3><a href="#" data-value_id="" class="clear clear_show">Clear</a></div><ul><li class="fil_val selected"><a href="#" data-value_id="current-only">Current</a><span class="fcount">(1)</span></li></ul></li></ul><div id="chr-location-facet-wrapper" data-bid="MCID_67d4a5204f3d5e000d638558" data-hid="MCID_67d2a666fe1ad803e8633767" data-qky="28373" class="disabled" style="display:none"><ul class="facet" data-filter_id="chromosomal-region" id="_chromosomal-region" data-of="yes"><li class="filter_grp of_grp"><div class="clearfix"><h3>Chromosome locations</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><a id="facet_ofchromosomal-region" href="#facet_of_divchromosomal-region" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'middle left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '375px'" data-value_id="fetch_more">more...</a><div id="facet_of_divchromosomal-region" style="display:none;" class="of_popup"><h4>Chromosome locations</h4><label for="organism-filter" style="width:100%;margin-bottom:.2em;" class="">Select an organism by typing or scrolling</label><input type="text" placeholder="Enter text to narrow down the list" id="organism-filter" style="width:98%;" autocomplete="off" /><br /><div id="chr-region-tax-list"><select id="of_chromosomal-region" size="9" class="chr-region-tax-list" style="width:100%;"></select></div><div id="chr-location-info-ctrl" data-disabled="disabled"><div class="chr-field"><label for="chr-name">Chromosome</label><br /><select id="chr-name" class="chr-field" disabled="disabled"></select></div><div class="chr-field"><label for="chr-from">From</label><br /><input type="text" name="chr-from" id="chr-from" disabled="disabled" class="chr-field" /></div><div class="chr-field"><label for="chr-to">To</label><br /><input type="text" name="chr-to" id="chr-to" disabled="disabled" class="chr-field" /></div></div><div class="actions clearfix"><button class="jig-ncbibutton of_add apply-chr" data-jigconfig="'color': 'ui-ncbibutton-blue'">Apply</button></div></div></ul></li></ul></div><ul class="facet facet_reset"><li><a href="#" data-value_id="reset">Clear all</a></li></ul><ul class="facet_tools"><li><a id="more_filter_groups_link" href="#more_filter_groups" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'top left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '180px'">
Show additional filters</a></li><div id="more_filter_groups" style="display:none;" class="facets_dialog"><button class="ui-ncbipopper-close-button ui-ncbipopper-close-button-generated ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-blue" generated="true" role="button" aria-disabled="false"><span class="ui-button-text">x</span></button><h4>Additional filters</h4><ul class="filter_groups_more facet"><li><input type="checkbox" id="fg_gene-sources" /><label for="fg_gene-sources">Gene sources</label></li><li><input type="checkbox" id="fg_categories" /><label for="fg_categories">Categories</label></li><li><input type="checkbox" id="fg_sequence-content" /><label for="fg_sequence-content">Sequence content</label></li><li><input type="checkbox" id="fg_status" /><label for="fg_status">Status</label></li><li><input type="checkbox" id="fg_chromosomal-region" /><label for="fg_chromosomal-region">Chromosome locations</label></li><li><input id="fg_field_search" type="checkbox" /><label for="fg_field_search">Search fields</label></li></ul><div class="actions clearfix"><button class="filter_groups_more_apply jig-ncbibutton primary-action" id="filter_groups_apply" data-jigconfig="'color': 'ui-ncbibutton-blue'">Show</button></div></div></ul><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetsUrlFrag" sid="1" type="hidden" value="filters=current-only" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetSubmitted" sid="1" type="hidden" value="false" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.BMFacets" sid="1" type="hidden" value="" /></div>
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<h1 class="title" id="gene-name"><span class="gn" style="padding-right:.5em;">MT-TK</span> mitochondrially encoded tRNA lysine [ <em class="tax">Homo sapiens</em> (human)
]
</h1>
<span class="geneid">Gene ID: 4566, updated on
4-Mar-2025</span>
</div>
<div class="download-datasets">
<script type="text/javascript" src="https://cdnjs.cloudflare.com/ajax/libs/axios/0.23.0/axios.min.js"></script>
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<a href="#">Download Datasets</a>
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<input type="checkbox" id="datasets-ft-gene-seq-fasta" value="FASTA_GENE" checked="checked" class="download-datasets-included-seq" />
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<input type="checkbox" id="datasets-ft-transcript-seq-fasta" value="FASTA_RNA" class="download-datasets-included-seq" />
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<input type="checkbox" id="datasets-ft-protein-seq-fasta" value="FASTA_PROTEIN" class="download-datasets-included-seq" />
<label for="datasets-ft-protein-seq-fasta">Protein sequences(FASTA)</label>
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<p style="margin-left:5px;">In addition, your package will include a detailed data report in both TSV and JSONL formats.</p>
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<label for="datasets-download-file-name">File name</label>
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<div class="rprt-body">
<div class="rprt-section gene-summary">
<section class="rprt-section-header" id="summary">
<h2 id="header-summary">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-summary .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Summary</span>
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<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
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<a href="/books/NBK3841/#EntrezGene.Summary_2" title="Help" class="gene-section-help">
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</section>
<div class="rprt-section-body">
<div id="summaryDiv" class="section">
<dl id="summaryDl">
<dt class="noline"> Official
Symbol</dt>
<dd class="noline">MT-TK<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
<dt> Official
Full Name</dt>
<dd>mitochondrially encoded tRNA lysine<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
<dt>Primary source</dt>
<dd>
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7489" data-gblink-text="Ensembl">HGNC:HGNC:7489</a>
</dd>
<dt>See related</dt>
<dd>
<a href="https://www.ncbi.nlm.nih.gov/omim/590060" data-gblink-text="Ensembl" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=590060">MIM:590060;</a>
<a href="https://www.alliancegenome.org/gene/HGNC:7489" data-gblink-text="Ensembl" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=HGNC:7489">AllianceGenome:HGNC:7489</a>
</dd>
<dt>Gene type</dt>
<dd>tRNA</dd>
<dt>Organism</dt>
<dd class="tax">
<a href="/Taxonomy/Browser/wwwtax.cgi?id=9606" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=9606">Homo sapiens</a>
</dd>
<dt>Lineage</dt>
<dd class="tax">Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo</dd>
<dt>Also known as</dt>
<dd>MTTK; TRNK</dd>
<dt style="padding-top:.5em;">
<span class="new-icon">NEW</span>
</dt>
<dd style="padding-top:.5em;">
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/4566/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="gene_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Gene table</a></strong>
<br />
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/4566/products/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="transcript_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Transcript table</a></strong>
</dd>
</dl>
</div>
</div>
</div>
<div class="rprt-section gene-genomic-context">
<section class="rprt-section-header" id="genomic-context">
<h2 id="header-genomic-context">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-context .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Genomic context</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
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<span>Help</span>
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</section>
<div class="rprt-section-body">
<div class="gc_cont">
<div class="gt_cont_contents">
<div style="float:right"><span>See MT-TK in </span><a href="/genome/gdv/?context=gene&amp;acc=4566" class="link-to-gdv genome-browser-link" data-genome-browser-link-sort="1" data-acc="">Genome Data Viewer</a> </div>
</div>
<div class="ui-ncbigrid-outer-div" id="genomic-context-tbl-location">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="">
<thead>
<tr>
<th style="max-width:15%">Annotation release</th>
<th style="max-width:10%">Status</th>
<th>Assembly</th>
<th>
<span title="Chromosome">Chr</span>
</th>
<th>Location</th>
</tr>
</thead>
<tbody>
<tr>
<td>RS_2024_08</td>
<td>current</td>
<td>GRCh38.p14 (<a href="/assembly/GCF_000001405.40/" ref="ncbi_uid=4566&amp;link_uid=GCF_000001405.40">GCF_000001405.40</a>)</td>
<td>MT (non-nuclear)</td>
<td>NC_012920.1 (8295..8364) </td>
</tr>
<tr>
<td>RS_2024_09</td>
<td>previous assembly</td>
<td>GRCh37.p13 (<a href="/assembly/GCF_000001405.25/" ref="ncbi_uid=4566&amp;link_uid=GCF_000001405.25">GCF_000001405.25</a>)</td>
<td>MT (non-nuclear)</td>
<td>NC_012920.1 (8295..8364) </td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<p class="withnote margin_t2em"><strong>Chromosome MT - NC_012920.1</strong><img usemap="#nbrMap4566_251831106" border="0" alt="Genomic Context describing neighboring genes" src="/gutils/geneneighb.fcgi?geneid=4566&amp;nuc_gi=251831106&amp;n0=TRND&amp;n1=COX2&amp;n2=TRNK&amp;n3=ATP8&amp;n4=ATP6&amp;n5=COX3" /><map name="nbrMap4566_251831106" id="nbrMap4566_251831106">
<area shape="rect" onMouseOver="showtip(this,event,'tRNA-Asp')" onMouseOut="hidetip()" coords="42,23,74,31" alt="Neighboring gene tRNA-Asp" href="/gene/4555" />
<area shape="rect" onMouseOver="showtip(this,event,'cytochrome c oxidase subunit II')" onMouseOut="hidetip()" coords="52,35,173,43" alt="Neighboring gene cytochrome c oxidase subunit II" href="/gene/4513" />
<area shape="rect" onMouseOver="showtip(this,event,'ATP synthase F0 subunit 8')" onMouseOut="hidetip()" coords="165,47,217,55" alt="Neighboring gene ATP synthase F0 subunit 8" href="/gene/4509" />
<area shape="rect" onMouseOver="showtip(this,event,'ATP synthase F0 subunit 6')" onMouseOut="hidetip()" coords="189,23,309,31" alt="Neighboring gene ATP synthase F0 subunit 6" href="/gene/4508" />
<area shape="rect" onMouseOver="showtip(this,event,'cytochrome c oxidase subunit III')" onMouseOut="hidetip()" coords="287,35,423,43" alt="Neighboring gene cytochrome c oxidase subunit III" href="/gene/4514" />
</map>
</p>
</div>
</div>
<div class="rprt-section gene-genomic-regions-transcripts-products">
<section class="rprt-section-header" id="genomic-regions-transcripts-products">
<h2 id="header-genomic-regions-transcripts-products">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-regions-transcripts-products .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Genomic regions, transcripts, and products</span>
</a>
</h2>
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<span>Go to the top of the page</span>
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</section>
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<div>
<div style="text-align:right;">Go to <a href="#reference-sequences">reference sequence details</a></div>
</div>
<div>
<p class="choose">
<label for="accession" class="label">Genomic Sequence: </label>
<select name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.accessionList" sid="1" id="accessionList" data-taxid="9606" data-geneid="4566">
<option value="NC_012920.1_8294_8363_A">NC_012920.1 Chromosome MT Reference GRCh38.p14 non-nuclear</option>
<option value="NC_012920.1_8294_8363_B">NC_012920.1 Chromosome MT Reference GRCh37.p13 non-nuclear</option>
</select>
</p>
</div>
<div id="NC_012920" class="divAccession">
<div class="seq-viewer">
<p class="note-link">
<strong>Go to nucleotide:</strong>
<a title="Nucleotide Graphic report" href="/nuccore/NC_012920.1?report=graph&amp;from=8284&amp;to=8373&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=NC_012920.1">Graphics</a>
<a title="Nucleotide FASTA report" href="/nuccore/NC_012920.1?report=fasta&amp;from=8295&amp;to=8364" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=NC_012920.1">FASTA</a>
<a title="Nucleotide GenBank report" href="/nuccore/NC_012920.1?report=genbank&amp;from=8295&amp;to=8364" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=NC_012920.1">GenBank</a>
</p>
<div id="divNC_012920" class="SeqViewerApp" style="clear:both;" data-sv="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_012920.1&amp;from=8284&amp;to=8373&amp;app_context=Gene&amp;assm_context=GCF_000001405.40">
<a href="?appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_012920.1&amp;from=8284&amp;to=8373&amp;app_context=Gene&amp;assm_context=GCF_000001405.40"></a>
</div>
</div>
</div>
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_012920.1" sid="1" type="hidden" id="nucleotideLink_NC_012920_1_8294_8363_A" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_012920.1?report=graph&amp;amp;from=8284&amp;amp;to=8373&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.40&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=4566&amp;amp;link_uid=NC_012920.1&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_012920.1?report=fasta&amp;amp;from=8295&amp;amp;to=8364&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=4566&amp;amp;link_uid=NC_012920.1&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_012920.1?report=genbank&amp;amp;from=8295&amp;amp;to=8364&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=4566&amp;amp;link_uid=NC_012920.1&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_012920.1" sid="1" type="hidden" id="relString_NC_012920_1_8294_8363_A" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_012920.1&amp;amp;from=8284&amp;amp;to=8373&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.40" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_012920.1" sid="2" type="hidden" id="nucleotideLink_NC_012920_1_8294_8363_B" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_012920.1?report=graph&amp;amp;from=8284&amp;amp;to=8373&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.25&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=4566&amp;amp;link_uid=NC_012920.1&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_012920.1?report=fasta&amp;amp;from=8295&amp;amp;to=8364&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=4566&amp;amp;link_uid=NC_012920.1&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_012920.1?report=genbank&amp;amp;from=8295&amp;amp;to=8364&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=4566&amp;amp;link_uid=NC_012920.1&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_012920.1" sid="2" type="hidden" id="relString_NC_012920_1_8294_8363_B" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_012920.1&amp;amp;from=8284&amp;amp;to=8373&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.25" />
</div>
</div>
<div class="rprt-section gene-bibliography">
<section class="rprt-section-header" id="bibliography"><h2 id="header-bibliography"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-bibliography .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Bibliography</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Bibliography" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
<div class="rprt-section-body" style="">
<div class="generif-pubmed">
<h3 id="relatedarticlesinpubmed">
<a href="#" class="jig-ncbitoggler-open">Related articles in PubMed</a>
</h3>
<div class="generefbl-link">
<ol class="generef-link">
<li>
<a href="/pubmed/26995359/" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=26995359">Expanded phenotypic spectrum of the m.8344A&gt;G "MERRF" mutation: data from the German mitoNET registry.</a>
<span class="pubmed-auth-date"> Altmann J, <em>et al</em>. J Neurol, 2016 May. PMID 26995359</span>
</li>
<li>
<a href="/pubmed/16810691/" ref="ordinalpos=2&amp;ncbi_uid=4566&amp;link_uid=16810691">Exercise intolerance associated with a novel 8300T &gt; C mutation in mitochondrial transfer RNAlys.</a>
<span class="pubmed-auth-date"> Gambello MJ, <em>et al</em>. Muscle Nerve, 2006 Oct. PMID 16810691</span>
</li>
<li>
<a href="/pubmed/17293137/" ref="ordinalpos=3&amp;ncbi_uid=4566&amp;link_uid=17293137">Resting muscle pain as the first clinical symptom in children carrying the MTTK A8344G mutation.</a>
<span class="pubmed-auth-date"> van de Glind G, <em>et al</em>. Eur J Paediatr Neurol, 2007 Jul. PMID 17293137</span>
</li>
<li>
<a href="/pubmed/17410322/" ref="ordinalpos=4&amp;ncbi_uid=4566&amp;link_uid=17410322">Sporadic myopathy and exercise intolerance associated with the mitochondrial 8328G&gt;A tRNALys mutation.</a>
<span class="pubmed-auth-date"> Blakely EL, <em>et al</em>. J Neurol, 2007 Sep. PMID 17410322</span>
</li>
<li>
<a href="/pubmed/19253012/" ref="ordinalpos=5&amp;ncbi_uid=4566&amp;link_uid=19253012">A8344G tRNALys mutation associated with recurrent brain stem stroke-like episodes.</a>
<span class="pubmed-auth-date"> Zaganas I, <em>et al</em>. J Neurol, 2009 Feb. PMID 19253012</span>
</li>
</ol>
<p class="see-all-pm">
<a href="/pubmed?LinkName=gene_pubmed&amp;from_uid=4566" title="See all 22 citations in Pubmed">See all (22) citations in PubMed</a>
</p>
</div>
</div>
<div class="generif-pubmed generif">
<h3 id="generifsgenereferencesintofunctions">
<a href="#" class="jig-ncbitoggler-open">GeneRIFs: Gene References Into Functions</a>
</h3>
<div>
<a href="/gene/about-generif" class="whatisthis">What's a GeneRIF?</a>
<div class="generefbl-link">
<ol class="generef-link">
<li class="gene-rif-popper">
<a href="/pubmed/35886028" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=35886028">A Novel MTTK Gene Variant m.8315A&amp;gt;C as a Cause of MERRF Syndrome.</a>
<div id="gene-popper1" class="gene-rif-popper">Title: A Novel MTTK Gene Variant m.8315A&gt;C as a Cause of MERRF Syndrome.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/26995359" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=26995359">Study further broadens the clinical spectrum of the m.8344A&gt;G mutation, document the large clinical variability between carriers of the same mutation, even within families and indicate an overlap of the phenotype with other mitochondrial DNA-associated syndromes</a>
<div id="gene-popper2" class="gene-rif-popper">Title: Expanded phenotypic spectrum of the m.8344A&gt;G "MERRF" mutation: data from the German mitoNET registry.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/22743145" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=22743145">provides evidence toward the pathogenicity of the m.8348A&gt;G mutation and suggest that m.5628T&gt;C is probably a neutral polymorphism.</a>
<div id="gene-popper3" class="gene-rif-popper">Title: The mutations m.5628T&gt;C and m.8348A&gt;G in single muscle fibers of a patient with chronic progressive external ophthalmoplegia.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/22681518" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=22681518">study of a Greek family that includes seven symptomatic cases of 8344 A&gt;G lys mitochondrial tRNA mutation; clustering of unusual manifestations in this kindred suggests that much of the phenotypic variability of 8344 A&gt;G is determined by mitochondrially encoded modifiers in cis</a>
<div id="gene-popper4" class="gene-rif-popper">Title: Familial clustering strongly suggests that the phenotypic variation of the 8344 A&gt;G lys mitochondrial tRNA mutation is encoded in cis.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/22227389" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=22227389">The results unambiguously demonstrate that modifications pre-structure the anticodon as a key prerequisite for efficient and accurate recognition of cognate and wobble codons by transfer RNA lysine.</a>
<div id="gene-popper5" class="gene-rif-popper">Title: Human tRNA(Lys3)(UUU) is pre-structured by natural modifications for cognate and wobble codon binding through keto-enol tautomerism.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/20610441" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=20610441">This is the first reported case of a double-point mutation in mtDNA, tRNA(Lys) and tRNA(Leu) genes, both of which were heteroplasmic and pathogenic for MERRF/MELAS overlap syndrome.</a>
<div id="gene-popper6" class="gene-rif-popper">Title: MERRF/MELAS overlap syndrome: a double pathogenic mutation in mitochondrial tRNA genes.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/19278689" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=19278689">we describe the clinical and molecular features of a new large multigenerational family with the G8363A mtDNA tRNA(Lys) gene mutation and we review the literature of cases with this mutation</a>
<div id="gene-popper7" class="gene-rif-popper">Title: Mitochondrial DNA G8363A mutation in the tRNA Lys gene: clinical, biochemical and pathological study.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/19266142" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=19266142">We describe a typical MERRF (A8344G) mutation of the mitochondrial DNA associated with depressive mood disorders.</a>
<div id="gene-popper8" class="gene-rif-popper">Title: The typical MERRF (A8344G) mutation of the mitochondrial DNA associated with depressive mood disorders.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/19253012" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=19253012">We describe a A8344G tRNALys mutation associated with recurrent brain stem stroke-like episodes in a 17 year-old girl.</a>
<div id="gene-popper9" class="gene-rif-popper">Title: A8344G tRNALys mutation associated with recurrent brain stem stroke-like episodes.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/19758471,19066432,18636170,17619138" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=19758471,19066432,18636170,17619138">Observational study of gene-disease association. (HuGE Navigator)</a>
<div id="gene-popper10" class="gene-rif-popper">Title: MtSNPscore: a combined evidence approach for assessing cumulative impact of mitochondrial variations in disease.</div>
</li>
</ol>
</div>
<div class="submit-genrif">
<span>Submit:</span>
<a href="/gene/submit-generif/?geneId=4566&amp;sym=MT-TK&amp;name=mitochondrially encoded tRNA lysine&amp;org=Homo sapiens">New GeneRIF</a>
<a href="/RefSeq/update.cgi?geneid=4566&amp;symbol=MT-TK;task=fixpub">Correction</a>
<a href="https://www.ncbi.nlm.nih.gov/gene?db=gene&amp;report=generif&amp;term=4566" class="seeall-generif">See all GeneRIFs (15)</a>
</div>
</div>
</div>
</div>
</div>
<div class="rprt-section gene-phenotypes">
<section class="rprt-section-header" id="phenotypes">
<h2 id="header-phenotypes">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-phenotypes .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Phenotypes</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Phenotype" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body info-phenotype">
<p class="nochild-link">
<a href="/gtr/tests/?term=TRNK[gene]">Find tests for this gene in the NIH Genetic Testing Registry (GTR)</a>
</p>
<p class="nochild-link">
<a href="/gap/PheGenI?tab=1&amp;gene=4566">Review eQTL and phenotype association data in this region using PheGenI</a>
</p>
<div>
<h3 id="associatedconditions">Associated conditions</h3>
<table class="jig-ncbigrid gtr-associated-cond">
<thead>
<tr>
<th class="description">Description</th>
<th>Tests</th>
</tr>
</thead>
<tbody>
<tr>
<td>
<a href="/gtr/conditions/C0162672" ref="ncbi_uid=4566&amp;link_uid=C0162672">MERRF syndrome</a>
<div class="gtr-associated-cond-extra">
<span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C0162672" ref="ncbi_uid=4566&amp;link_uid=C0162672">C0162672</a></span>
<span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/545000" ref="ncbi_uid=4566"> 545000</a></span>
<span class="gtr-associated-cond-extra-i">GeneReviews: <a href="/books/NBK1224" ref="ncbi_uid=4566">Primary Mitochondrial Disorders Overview</a>, <a href="/books/NBK1520" ref="ncbi_uid=4566">MERRF</a></span>
</div>
</td>
<td>
<a href="/gtr/tests/?term=C0162672[DISCUI]&amp;condition=C0162672&amp;compare_labs=1" ref="ncbi_uid=4566">Compare labs</a>
</td>
</tr>
<tr>
<td>
<a href="/gtr/conditions/C0162671" ref="ncbi_uid=4566&amp;link_uid=C0162671">MELAS syndrome</a>
<div class="gtr-associated-cond-extra">
<span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C0162671" ref="ncbi_uid=4566&amp;link_uid=C0162671">C0162671</a></span>
<span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/540000" ref="ncbi_uid=4566"> 540000</a></span>
<span class="gtr-associated-cond-extra-i">GeneReviews: <a href="/books/NBK1224" ref="ncbi_uid=4566">Primary Mitochondrial Disorders Overview</a>, <a href="/books/NBK1233" ref="ncbi_uid=4566">MELAS</a></span>
</div>
</td>
<td>
<a href="/gtr/tests/?term=C0162671[DISCUI]&amp;condition=C0162671&amp;compare_labs=1" ref="ncbi_uid=4566">Compare labs</a>
</td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<div class="rprt-section gene-variation">
<section class="rprt-section-header" id="variation">
<h2 id="header-variation">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-variation .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Variation</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.variation" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<p class="nochild-link">
<a href="/clinvar/?term=MT-TK[gene]" ref="log$=recordlinks">See variants in ClinVar</a>
</p>
<p class="nochild-link">
<a href="/dbvar?LinkName=gene_dbvar&amp;from_uid=4566" ref="log$=recordlinks">See studies and variants in dbVar</a>
</p>
<p class="nochild-link">
<a href="/variation/view/?q=4566[geneid]&amp;assm=GCF_000001405.25" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh37.p13)">See Variation Viewer (GRCh37.p13)</a>
</p>
<p class="nochild-link">
<a href="/variation/view/?q=4566[geneid]" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh38)">See Variation Viewer (GRCh38)</a>
</p>
<set></set>
<set></set>
</div>
</div>
<div class="rprt-section gene-general-gene-info">
<section class="rprt-section-header" id="general-gene-info">
<h2 id="header-general-gene-info">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-gene-info .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">General gene information</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.General_Gene_Information" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body" style="">
<div id="gene-markers">
<h3 id="markers">
<a class="jig-ncbitoggler">Markers</a>
</h3>
<div>
<ul class="marker odd">
<li class="marker">D17S813E (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=92461%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=92461">UniSTS:92461</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">PMC109173P1 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=270154%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=270154">UniSTS:270154</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">PMC20756P1 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=271961%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=271961">UniSTS:271961</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">SHGC-57364 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=67674%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=67674">UniSTS:67674</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">PMC20756P2 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=271962%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=271962">UniSTS:271962</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">PMC20756P3 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=271963%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=271963">UniSTS:271963</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">RH98513 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=83580%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=83580">UniSTS:83580</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">D1S2077E (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=151716%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=151716">UniSTS:151716</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">PMC55343P2 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=273325%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=273325">UniSTS:273325</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">PMC55343P3 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=273326%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=273326">UniSTS:273326</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">PMC55343P4 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=273327%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=273327">UniSTS:273327</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">PMC196577P3 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=271816%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4566&amp;link_uid=271816">UniSTS:271816</a></li></ul></li>
</ul>
</div>
</div>
<div></div>
<!--<component id="Gene_InfoPathway"/>-->
<div class="infosec info-comment" id="info-comment">
<ul class="geneinfo-subsec">
<li>NAR: 1197 </li>
</ul>
</div>
</div>
</div>
<div class="rprt-section gene-additional-links">
<section class="rprt-section-header" id="additional-links"><h2 id="header-additional-links"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-additional-links .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Additional links</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Additional_Links" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
<div class="rprt-section-body" style="">
<h3 class="withnote" id="genelinkout">
<a class="jig-ncbitoggler">Gene LinkOut</a>
</h3><div>
<p>The following <a href="https://www.ncbi.nlm.nih.gov/projects/linkout/index.html">LinkOut</a> resources are supplied by external providers. These providers are responsible for maintaining the links. </p>
<div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Other Literature Sources</span>
</a>
<ul>
<li><span class="free-rsc"></span>Dryad Digital Repository</li>
<ul>
<li>
<a target="_blank" href="https://datadryad.org/stash/dataset/doi:10.5061/dryad.2k4v4" ref="itool=Gene_FullReport&amp;uid=4566&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7893">
<span>Dryad Digital Repository</span>
</a>
</li>
<li>
<a target="_blank" href="https://datadryad.org/stash/dataset/doi:10.5061/dryad.bq4t8" ref="itool=Gene_FullReport&amp;uid=4566&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7893">
<span>Dryad Digital Repository</span>
</a>
</li>
<li>
<a target="_blank" href="https://datadryad.org/stash/dataset/doi:10.5061/dryad.g9f5r" ref="itool=Gene_FullReport&amp;uid=4566&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7893">
<span>Dryad Digital Repository</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Medical</span>
</a>
<ul>
<li><span class="free-rsc"></span>MedlinePlus Health Information</li>
<ul>
<li>
<a target="_blank" href="https://medlineplus.gov/genetics/gene/mt-tk" ref="itool=Gene_FullReport&amp;uid=4566&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=3162">
<span>MT-TK gene</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Molecular Biology Databases</span>
</a>
<ul>
<li><span class="free-rsc"></span>Bgee database</li>
<ul>
<li>
<a target="_blank" href="https://www.bgee.org/gene/ENSG00000210156" ref="itool=Gene_FullReport&amp;uid=4566&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10418">
<span>MT-TK gene expression</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>BioGPS</li>
<ul>
<li>
<a target="_blank" href="http://biogps.org/gene/4566/" ref="itool=Gene_FullReport&amp;uid=4566&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5059">
<span>BioGPS</span>
</a>
</li>
</ul>
<li>Ingenuity Pathways Analysis</li>
<ul>
<li>
<a target="_blank" href="http://partnersolution.ingenuity.com/?cid=97ae3f91eab87a&amp;p1=Entrez&amp;p2=GV&amp;s=&amp;ipaUri=%2Fpa%2Fapi%2Fv2%2Fgeneview%3Fapplicationname%3DEntrez%26geneId%3D4566%26geneidtype%3Dentrezgene" ref="itool=Gene_FullReport&amp;uid=4566&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5628">
<span>Ingenuity Pathways Analysis</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>InterMine</li>
<ul>
<li>
<a target="_blank" href="https://www.humanmine.org/humanmine/search?keyword=ENSG00000210156" ref="itool=Gene_FullReport&amp;uid=4566&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9169">
<span>InterMine</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Kyoto Encyclopedia of Genes and Genomes</li>
<ul>
<li>
<a target="_blank" href="http://www.genome.jp/dbget-bin/www_bget?hsa:4566" ref="itool=Gene_FullReport&amp;uid=4566&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5174">
<span>Kyoto Encyclopedia of Genes and Genomes</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>The Weizmann Institute of Science GeneCards and MalaCards databases</li>
<ul>
<li>
<a target="_blank" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=MT-TK" ref="itool=Gene_FullReport&amp;uid=4566&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8598">
<span>GeneCard for MT-TK</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Research Materials</span>
</a>
<ul>
<li><span class="order-rsc"></span>GenScript latest version of gene cDNA ORF Clone</li>
<ul>
<li>
<a target="_blank" href="http://www.genscript.com/gene/4566" ref="itool=Gene_FullReport&amp;uid=4566&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8012">
<span>GenScript latest version of gene cDNA ORF Clone</span>
</a>
</li>
</ul>
</ul>
</div>
</div>
</div>
<div id="urls-in-genombrowser" style="display:none">
</div>
</div>
</div>
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</div>
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<!-- sidebar close/hide button-->
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<!-- end sidebar close/hide button-->
<h2 class="offscreen_noflow">Supplemental Content</h2>
<div id="gene-sidebar">
<div>
<div class="portlet brieflink dis-table-of-contents">
<div class="portlet_head">
<div class="portlet_title">
<h3>Table of contents</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_TableOfContents" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li class="">
<a href="#summary">Summary</a>
</li>
<li class="">
<a href="#genomic-context">Genomic context</a>
</li>
<li class="">
<a href="#genomic-regions-transcripts-products">Genomic regions, transcripts, and products</a>
</li>
<li class="">
<a href="#bibliography">Bibliography</a>
</li>
<li class="">
<a href="#phenotypes">Phenotypes</a>
</li>
<li class="">
<a href="#variation">Variation</a>
</li>
<li class="">
<a href="#general-gene-info">General gene information</a>
<div class="subsection-links">
<a href="#gene-markers">Markers</a>
</div>
</li>
<li class="">
<a href="#additional-links">Additional links</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-genomesbrowser brieflink dis-genomesbrowser">
<div class="portlet_head">
<div class="portlet_title">
<h3>Genome Browsers</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GenomeBrowsers.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GenomeBrowsers" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GenomeBrowsers.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="#">Loading...</a>
</li>
</ul>
</div>
</div>
<div class="portlet dis-related-info brieflink">
<div class="portlet_head">
<div class="portlet_title">
<h3>Related information</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter"></a>
</div>
<div class="portlet_content DiscoveryDbLinks">
<ul>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/bioproject?LinkName=gene_bioproject&amp;from_uid=4566" ref="log$=recordlinks">BioProjects</a>
<div class="brieflinkpop offscreen_noflow">BioProjects related to a gene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/biosystems?LinkName=gene_biosystems&amp;from_uid=4566" ref="log$=recordlinks">BioSystems</a>
<div class="brieflinkpop offscreen_noflow">BioSystems</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar&amp;from_uid=4566" ref="log$=recordlinks">ClinVar</a>
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/dbvar?LinkName=gene_dbvar&amp;from_uid=4566" ref="log$=recordlinks">dbVar</a>
<div class="brieflinkpop offscreen_noflow">Link from Gene to dbVar</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc&amp;from_uid=4566" ref="log$=recordlinks">Full text in PMC</a>
<div class="brieflinkpop offscreen_noflow">PMC links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc_nucleotide&amp;from_uid=4566" ref="log$=recordlinks">Full text in PMC_nucleotide</a>
<div class="brieflinkpop offscreen_noflow">Full text in PubMedCentral identified from shared sequence links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gene?LinkName=gene_gene_neighbors&amp;from_uid=4566" ref="log$=recordlinks">Gene neighbors</a>
<div class="brieflinkpop offscreen_noflow">Overlapping genes and two nearest non-overlapping genes on either side</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/genome?LinkName=gene_genome&amp;from_uid=4566" ref="log$=recordlinks">Genome</a>
<div class="brieflinkpop offscreen_noflow">Related Genome</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/geoprofiles?LinkName=gene_geoprofiles&amp;from_uid=4566" ref="log$=recordlinks">GEO Profiles</a>
<div class="brieflinkpop offscreen_noflow">Related GEO</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gtr/tests/?term=4566[geneid]" ref="log$=recordlinks">GTR</a>
<div class="brieflinkpop offscreen_noflow">Tests for this gene in the NIH Genetic Testing Registry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/medgen?LinkName=gene_medgen_diseases&amp;from_uid=4566" ref="log$=recordlinks">MedGen</a>
<div class="brieflinkpop offscreen_noflow">Related information in MedGen</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore&amp;from_uid=4566" ref="log$=recordlinks">Nucleotide</a>
<div class="brieflinkpop offscreen_noflow">Link to related Nucleotide entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/omim?LinkName=gene_omim&amp;from_uid=4566" ref="log$=recordlinks">OMIM</a>
<div class="brieflinkpop offscreen_noflow">Link to related OMIM entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/probe?LinkName=gene_probe&amp;from_uid=4566" ref="log$=recordlinks">Probe</a>
<div class="brieflinkpop offscreen_noflow">Related Probe entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed&amp;from_uid=4566" ref="log$=recordlinks">PubMed</a>
<div class="brieflinkpop offscreen_noflow">Link to related PubMed entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_rif&amp;from_uid=4566" ref="log$=recordlinks">PubMed (GeneRIF)</a>
<div class="brieflinkpop offscreen_noflow">Link to related PubMed article from GeneRIFs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_citedinomim&amp;from_uid=4566" ref="log$=recordlinks">PubMed (OMIM)</a>
<div class="brieflinkpop offscreen_noflow">Gene links to PubMed derived from omim_pubmed_cited links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_pmc_nucleotide&amp;from_uid=4566" ref="log$=recordlinks">PubMed(nucleotide/PMC)</a>
<div class="brieflinkpop offscreen_noflow">Citations in PubMed identified from shared sequence and PMC links.</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar_specific&amp;from_uid=4566" ref="log$=recordlinks">Related gene-specific medical variations</a>
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/taxonomy?LinkName=gene_taxonomy&amp;from_uid=4566" ref="log$=recordlinks">Taxonomy</a>
<div class="brieflinkpop offscreen_noflow">Link to related taxonomy entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/variation/view/?q=4566[geneid]" ref="log$=recordlinks">Variation Viewer</a>
<div class="brieflinkpop offscreen_noflow">Related Variants</div>
</li>
</ul>
</div>
</div>
<div class="portlet dis-links-to-other-res brieflink">
<div class="portlet_head">
<div class="portlet_title">
<h3>Links to other resources</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_LinksTwo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7489">HGNC</a>
</li>
<li>
<a href="https://www.alliancegenome.org/gene/HGNC:7489">AllianceGenome</a>
</li>
<li>
<a href="https://phgkb.cdc.gov/PHGKB/huGEPedia.action?firstQuery=TRNK&amp;geneID=4566&amp;typeOption=gene&amp;which=2&amp;pubOrderType=pubD&amp;typeSubmit=GO&amp;check=y">HuGE Navigator</a>
</li>
<li>
<a href="http://www.genome.jp/dbget-bin/www_bget?hsa:4566">KEGG</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-general-info">
<div class="portlet_head">
<div class="portlet_title">
<h3>General information</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GeneralInfo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="/pmc/?term=PMC4383897+OR+PMC3013746+OR+PMC1761442+OR+PMC539985">About Gene</a>
</li>
<li>
<a href="/books/NBK3840">FAQ</a>
</li>
<li>
<a href="https://ftp.ncbi.nlm.nih.gov/gene/">FTP site</a>
</li>
<li>
<a href="/books/NBK3841/">Help</a>
</li>
<li>
<a href="/books/NBK3842/">My NCBI help</a>
</li>
<li>
<a href="/books/NBK21085/">NCBI Handbook</a>
</li>
<li>
<a href="/gene/statistics/">Statistics</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-related-sites">
<div class="portlet_head">
<div class="portlet_title">
<h3>Related sites</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_RelatedSites" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://www.ncbi.nlm.nih.gov/BLAST">BLAST</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/genome">Genome</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/bioproject">BioProject</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/genome/gdv/">Genome Data Viewer</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/geo">GEO</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/omim">OMIM</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/probe">Probe</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/RefSeq">RefSeq</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-feedback">
<div class="portlet_head">
<div class="portlet_title">
<h3>Feedback</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_Feedback" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://support.ncbi.nlm.nih.gov/ics/support/ticketnewwizard.asp?style=classic&amp;deptID=28049">Contact Help Desk</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/RefSeq/update.cgi?geneid=4566&amp;symbol=MT-TK">Submit Correction</a>
</li>
<li>
<a href="/gene/submit-generif?geneId=4566&amp;sym=MT-TK&amp;name=mitochondrially encoded tRNA lysine&amp;org=Homo sapiens">Submit GeneRIF</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-subscription">
<div class="portlet_head">
<div class="portlet_title">
<h3>Subscription</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Subscription.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_Subscription" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Subscription.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://www.ncbi.nlm.nih.gov/mailman/listinfo/refseq-announce">RefSeq</a>
</li>
</ul>
</div>
</div>
</div>
<!-- <component id="Gene_RVFullReport.Gene_RightColMenuLinks"/>-->
<div class="portlet">
<div class="portlet_head">
<div class="portlet_title">
<h3>Recent activity</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="recent_activity" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.Shutter"></a>
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<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.ClearHistory" sid="1" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.ClearHistory" cmd="ClearHT" href="?cmd=ClearHT&amp;" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.ClearHistory">
Clear
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Turn Off
</a>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" sid="2" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOff" cmd="HTOn" href="?cmd=HTOn&amp;" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle">
Turn On
</a>
</div>
<ul id="activity">
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67d4a5212f30673f7b2c211b">MT-TK mitochondrially encoded tRNA lysine [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">MT-TK mitochondrially encoded tRNA lysine [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:4566</div></div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67d4a51fcde49f3df70d3730">MT-TF mitochondrially encoded tRNA phenylalanine [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">MT-TF mitochondrially encoded tRNA phenylalanine [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:4558</div></div>
<div class="tertiary">Gene</div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67d4a51e2f30673f7b2c1535">MT-TC mitochondrially encoded tRNA cysteine [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">MT-TC mitochondrially encoded tRNA cysteine [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:4511</div></div>
<div class="tertiary">Gene</div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67d4a50367c23b31e0e7a7fd">MELAS - GeneReviews®</a>
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<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67d4a5012f30673f7b2bbd5b">Table B. [OMIM Entries for MELAS (View All in OMIM)]. - GeneReviews®</a>
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