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2876 lines
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228 KiB
XML
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<h1 class="res_name"><a href="/gene/">Gene</a></h1>
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<h2 class="res_tagline">Genes and mapped phenotypes</h2>
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<div class="search"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="pubmed">PubMed</option><option value="clinvar">ClinVar</option><option value="medgen">MedGen</option><option value="books" class="last">Books</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly" data-ac_dict="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene" selected="selected" data-ac_dict="gene">Gene</option><option value="genome" data-ac_dict="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen">MedGen</option><option value="mesh">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore" data-ac_dict="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein" data-ac_dict="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search Gene. Use up and down arrows to choose an item from the autocomplete." value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="dictionary:'gene',disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'yes',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div><ul class="searchlinks inline_list"><set></set><li><a href="/gene/advanced">Advanced</a></li><li class="help"><a id="help" class="jig-ncbihelpwindow" target="ncbihelp" name="help" href="/books/NBK3841/">Help</a></li></ul></div>
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<input name="EntrezSystem2.PEntrez.Gene.Gene_PageController.PreviousPageName" sid="1" type="hidden" value="results" />
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<div id="faceted_search" class="facet_hide">
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<h2 class="offscreen_noflow">Result Filters</h2>
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<div class="facet_cont" data-db="gene" data-default_grps="fg_gene-sources,fg_categories,fg_sequence-content,fg_status" data-sd="db:'gene',op:'select',term:'',qk:'3332',linkname:'',idsfromresult:'3125',extra:''"><ul class="facet" data-filter_id="gene-sources" id="_gene-sources"><li class="filter_grp "><div class="clearfix"><h3>Gene sources</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="genomic">Genomic</a></li></ul></li></ul><ul class="facet" data-filter_id="categories" id="_categories"><li class="filter_grp "><div class="clearfix"><h3>Categories</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="annotated-genes">Annotated genes</a></li><li class="fil_val"><a href="#" data-value_id="gene-type-protein-coding">Protein-coding</a></li></ul></li></ul><ul class="facet" data-filter_id="sequence-content" id="_sequence-content"><li class="filter_grp "><div class="clearfix"><h3>Sequence content</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="refseq">RefSeq</a></li></ul></li></ul><ul class="facet" data-filter_id="status" id="_status"><li class="filter_grp "><div class="clearfix"><h3>Status</h3><a href="#" data-value_id="" class="clear clear_show">Clear</a></div><ul><li class="fil_val selected"><a href="#" data-value_id="current-only">Current</a><span class="fcount">(1)</span></li></ul></li></ul><div id="chr-location-facet-wrapper" data-bid="MCID_67c9de5669195c35ad6d485a" data-hid="MCID_67c90f2d64f30b25346ccae2" data-qky="3332" class="disabled" style="display:none"><ul class="facet" data-filter_id="chromosomal-region" id="_chromosomal-region" data-of="yes"><li class="filter_grp of_grp"><div class="clearfix"><h3>Chromosome locations</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><a id="facet_ofchromosomal-region" href="#facet_of_divchromosomal-region" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'middle left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '375px'" data-value_id="fetch_more">more...</a><div id="facet_of_divchromosomal-region" style="display:none;" class="of_popup"><h4>Chromosome locations</h4><label for="organism-filter" style="width:100%;margin-bottom:.2em;" class="">Select an organism by typing or scrolling</label><input type="text" placeholder="Enter text to narrow down the list" id="organism-filter" style="width:98%;" autocomplete="off" /><br /><div id="chr-region-tax-list"><select id="of_chromosomal-region" size="9" class="chr-region-tax-list" style="width:100%;"></select></div><div id="chr-location-info-ctrl" data-disabled="disabled"><div class="chr-field"><label for="chr-name">Chromosome</label><br /><select id="chr-name" class="chr-field" disabled="disabled"></select></div><div class="chr-field"><label for="chr-from">From</label><br /><input type="text" name="chr-from" id="chr-from" disabled="disabled" class="chr-field" /></div><div class="chr-field"><label for="chr-to">To</label><br /><input type="text" name="chr-to" id="chr-to" disabled="disabled" class="chr-field" /></div></div><div class="actions clearfix"><button class="jig-ncbibutton of_add apply-chr" data-jigconfig="'color': 'ui-ncbibutton-blue'">Apply</button></div></div></ul></li></ul></div><ul class="facet facet_reset"><li><a href="#" data-value_id="reset">Clear all</a></li></ul><ul class="facet_tools"><li><a id="more_filter_groups_link" href="#more_filter_groups" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'top left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '180px'">
|
||
Show additional filters</a></li><div id="more_filter_groups" style="display:none;" class="facets_dialog"><button class="ui-ncbipopper-close-button ui-ncbipopper-close-button-generated ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-blue" generated="true" role="button" aria-disabled="false"><span class="ui-button-text">x</span></button><h4>Additional filters</h4><ul class="filter_groups_more facet"><li><input type="checkbox" id="fg_gene-sources" /><label for="fg_gene-sources">Gene sources</label></li><li><input type="checkbox" id="fg_categories" /><label for="fg_categories">Categories</label></li><li><input type="checkbox" id="fg_sequence-content" /><label for="fg_sequence-content">Sequence content</label></li><li><input type="checkbox" id="fg_status" /><label for="fg_status">Status</label></li><li><input type="checkbox" id="fg_chromosomal-region" /><label for="fg_chromosomal-region">Chromosome locations</label></li><li><input id="fg_field_search" type="checkbox" /><label for="fg_field_search">Search fields</label></li></ul><div class="actions clearfix"><button class="filter_groups_more_apply jig-ncbibutton primary-action" id="filter_groups_apply" data-jigconfig="'color': 'ui-ncbibutton-blue'">Show</button></div></div></ul><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetsUrlFrag" sid="1" type="hidden" value="filters=current-only" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetSubmitted" sid="1" type="hidden" value="false" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.BMFacets" sid="1" type="hidden" value="" /></div>
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<div class="sidecontentpullout_local" id="sidecontent_1_pullout" rel="1" style="position: fixed !important; top: 118px; z-index: 1000; cursor: pointer; right: 0px; width: 12px;display:none;">
|
||
<span style="display: block; text-align: center;">S</span>
|
||
<span style="display: block; text-align: center;">I</span>
|
||
<span style="display: block; text-align: center;">D</span>
|
||
<span style="display: block; text-align: center;">E</span>
|
||
<span style="display: block; text-align: center;">B</span>
|
||
<span style="display: block; text-align: center;">A</span>
|
||
<span style="display: block; text-align: center;">R</span>
|
||
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<div class="results_settings one_setting"><ul class="inline_list left display_settings"><li><a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Display" sid="0" href="#" class="jig-ncbipopper" data-jigconfig="triggerPosition : 'bottom center',destPosition : 'top center',destSelector : '#display_settings_menu_report', hasArrow : false,openEvent : 'click',closeEvent : 'click',isTriggerElementCloseClick: false,addCloseButton : false, groupName: 'entrez_pg'" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Display">Full Report<span href="#" class="tgt_dark"></span></a></li></ul><div id="display_settings_menu_report" class="disp_settings tabPopper"><fieldset class="format"><legend>Format</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="1" value="full_report" format="" id="full_report" checked="true" /><label for="full_report">Full Report</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="2" value="full_report" format="text" id="full_reporttext" /><label for="full_reporttext">Full Report (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="3" value="expression" format="" id="expression" /><label for="expression">Expression</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="4" value="gene_table" format="" id="gene_table" /><label for="gene_table">Gene Table</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="5" value="gene_table" format="text" id="gene_tabletext" /><label for="gene_tabletext">Gene Table (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="6" value="generif" format="" id="generif" /><label for="generif">GeneRIF</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="7" value="docsum" format="" id="docsum" /><label for="docsum">Summary</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="8" value="docsum" format="text" id="docsumtext" /><label for="docsumtext">Summary (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="9" value="tabular" format="" id="tabular" /><label for="tabular">Tabular</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="10" value="tabular" format="text" id="tabulartext" /><label for="tabulartext">Tabular (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="11" value="asn1" format="text" id="asn1text" /><label for="asn1text">ASN.1</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="12" value="xml" format="text" id="xmltext" /><label for="xmltext">XML</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="13" value="uilist" format="text" id="uilisttext" /><label for="uilisttext">UI List</label></li></ul></fieldset></div><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SetDisplay" sid="1" class="button_apply ncbipopper-close-button" style="display:none">Apply</button><h4 class="content_header send_to align_right jig-ncbipopper" id="sendto" data-jigconfig="triggerPosition:'bottom center', destPosition : 'top center',destSelector : '#send_to_menu', hasArrow : false, openEvent : 'click',closeEvent : 'click', isTriggerElementCloseClick: false, addCloseButton:true, groupName: 'entrez_pg', adjustFit:'none'"><a href="#" sourceContent="send_to_menu" class="tgt_dark">Send to:</a><script type="text/javascript">
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var selectedValue = jQuery(this).val().toLowerCase();
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jQuery("#send_to_menu div.submenu:visible").css("display","none");
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|
||
</script></h4><div id="send_to_menu" class="tabPopper send_to"><fieldset><legend>Choose Destination</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendTo" sid="1" value="File" id="dest_File" /><label for="dest_File">File</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendTo" sid="2" value="AddToClipboard" id="dest_AddToClipboard" /><label for="dest_AddToClipboard">Clipboard</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendTo" sid="3" value="AddToCollections" id="dest_AddToCollections" /><label for="dest_AddToCollections">Collections</label></li></ul></fieldset><div class="submenu file" id="submenu_File" style="display: none;"><p id="submenu_File_hint" class="hidden"></p><ul><li><label for="file_format">Format</label><select id="file_format" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.FFormat" sid="1"><option value="full_report" format="text" selected="selected">Full Report (text)</option><option value="gene_table" format="text">Gene Table (text)</option><option value="docsum" format="text">Summary (text)</option><option value="tabular" format="text">Tabular (text)</option><option value="asn1" format="text">ASN.1</option><option value="xml" format="text">XML</option><option value="uilist" format="text">UI List</option></select></li></ul><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendToSubmit" sid="1" class="button_apply file ncbipopper-close-button" type="submit" cmd="File">Create File</button></div><div class="submenu addtoclipboard" id="submenu_AddToClipboard" style="display: none;"><p id="submenu_AddToClipboard_hint" class="hidden"></p><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendToSubmit" sid="2" class="button_apply clipboard ncbipopper-close-button" type="submit" cmd="AddToClipboard">Add to Clipboard</button></div><div class="submenu addtocollections" id="submenu_AddToCollections" style="display: none;"><p id="submenu_AddToCollections_hint" class="hidden"></p><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendToSubmit" sid="3" class="button_apply collections ncbipopper-close-button" type="submit" cmd="AddToCollections">Add to Collections</button></div></div><div><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.FileFormat" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastPresentation" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Presentation" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastPageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Sort" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastSort" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.FileSort" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Format" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastFormat" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PrevPageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PrevPresentation" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PrevSort" sid="1" type="hidden" value="" /><input type="hidden" id="coll_startindex" name="CollectionStartIndex" value="1" /></div></div>
|
||
<div>
|
||
|
||
|
||
|
||
</div>
|
||
<div class="">
|
||
<div><span id="result_sel" class="nowrap"></span><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_ResultsController.ResultCount" sid="1" type="hidden" id="resultcount" value="1" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_ResultsController.RunLastQuery" sid="1" type="hidden" /></div>
|
||
|
||
</div>
|
||
<div id="messagearea" class="empty">
|
||
|
||
|
||
|
||
|
||
</div>
|
||
<div class="rprt full-rprt">
|
||
<div>
|
||
<div class="rprt-header">
|
||
<input type="hidden" id="gene-tax-id" value="9606" />
|
||
<h1 class="title" id="gene-name"><span class="gn" style="padding-right:.5em;">HLA-DRB3</span> major histocompatibility complex, class II, DR beta 3 [ <em class="tax">Homo sapiens</em> (human)
|
||
]
|
||
</h1>
|
||
<span class="geneid">Gene ID: 3125, updated on
|
||
4-Mar-2025</span>
|
||
</div>
|
||
<div class="download-datasets">
|
||
<script type="text/javascript" src="https://cdnjs.cloudflare.com/ajax/libs/axios/0.23.0/axios.min.js"></script>
|
||
<h4 class="download-datasets-popper jig-ncbipopper" id="download-asm" style="align-self:start" data-jigconfig="triggerPosition:'bottom center', destPosition : 'top center',destSelector : '#download-datasets-popper-menu', hasArrow : false, openEvent : 'click',closeEvent : 'click', isTriggerElementCloseClick: false, groupName: 'entrez_pg', adjustFit:'none'" role="button" aria-expanded="false" aria-haspopup="true">
|
||
<svg alt="download" class="dlbtn-icon" x="0px" y="0px" width="15px" height="15px" viewBox="0 0 60 60" enable-background="new 0 0 60 60" xml:space="preserve">
|
||
<g>
|
||
<polygon points="48.75,36.25 48.75,48.75 11.25,48.75 11.25,36.25 5,36.25 5,55 55,55 55,36.25 "></polygon>
|
||
<polygon points="42.5,23.75 36.25,23.75 36.25,5 23.75,5 23.75,23.75 17.5,23.75 30,42.5 "></polygon>
|
||
</g>
|
||
</svg>
|
||
<a href="#">Download Datasets</a>
|
||
</h4>
|
||
<div id="download-datasets-popper-menu" style="display:none;">
|
||
<div class="input-group">
|
||
<input type="checkbox" id="datasets-ft-gene-seq-fasta" value="FASTA_GENE" checked="checked" class="download-datasets-included-seq" />
|
||
<label for="datasets-ft-gene-seq-fasta">Gene Sequences (FASTA)</label>
|
||
</div>
|
||
<div class="input-group">
|
||
<input type="checkbox" id="datasets-ft-transcript-seq-fasta" value="FASTA_RNA" class="download-datasets-included-seq" />
|
||
<label for="datasets-ft-transcript-seq-fasta">Transcript sequences (FASTA)</label>
|
||
</div>
|
||
<div class="input-group">
|
||
<input type="checkbox" id="datasets-ft-protein-seq-fasta" value="FASTA_PROTEIN" class="download-datasets-included-seq" />
|
||
<label for="datasets-ft-protein-seq-fasta">Protein sequences(FASTA)</label>
|
||
</div>
|
||
<p style="margin-left:5px;">In addition, your package will include a detailed data report in both TSV and JSONL formats.</p>
|
||
<div class="input-group">
|
||
<label for="datasets-download-file-name">File name</label>
|
||
<input type="text" id="datasets-download-file-name" placeholder="Name your file" style="padding:5px;" value="HLA-DRB3_datasets.zip" />
|
||
</div>
|
||
<input type="hidden" id="download-datasets-base-url" value="https://api.ncbi.nlm.nih.gov/datasets/v2alpha/gene/download" />
|
||
<input type="hidden" id="gene-id-value" value="3125" />
|
||
<button id="datasets-download-submit" data-ga-action="click_begin_download" data-ga-label="download" class="jig-ncbibutton ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-gray" role="button">
|
||
<span class="ui-button-text">Download</span>
|
||
</button>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-body">
|
||
|
||
|
||
<div class="rprt-section gene-summary">
|
||
<section class="rprt-section-header" id="summary">
|
||
<h2 id="header-summary">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-summary .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Summary</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Summary_2" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div id="summaryDiv" class="section">
|
||
<dl id="summaryDl">
|
||
<dt class="noline"> Official
|
||
Symbol</dt>
|
||
<dd class="noline">HLA-DRB3<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
|
||
<dt> Official
|
||
Full Name</dt>
|
||
<dd>major histocompatibility complex, class II, DR beta 3<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
|
||
<dt>Primary source</dt>
|
||
<dd>
|
||
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4951" data-gblink-text="Ensembl">HGNC:HGNC:4951</a>
|
||
</dd>
|
||
<dt>See related</dt>
|
||
<dd>
|
||
<a href="https://www.ncbi.nlm.nih.gov/omim/612735" data-gblink-text="Ensembl" ref="ordinalpos=1&ncbi_uid=3125&link_uid=612735">MIM:612735;</a>
|
||
<a href="https://www.alliancegenome.org/gene/HGNC:4951" data-gblink-text="Ensembl" ref="ordinalpos=1&ncbi_uid=3125&link_uid=HGNC:4951">AllianceGenome:HGNC:4951</a>
|
||
</dd>
|
||
<dt>Gene type</dt>
|
||
<dd>protein coding</dd>
|
||
<dt>RefSeq status</dt>
|
||
<dd>VALIDATED</dd>
|
||
<dt>Organism</dt>
|
||
<dd class="tax">
|
||
<a href="/Taxonomy/Browser/wwwtax.cgi?id=9606" ref="ordinalpos=1&ncbi_uid=3125&link_uid=9606">Homo sapiens</a>
|
||
</dd>
|
||
<dt>Lineage</dt>
|
||
<dd class="tax">Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo</dd>
|
||
<dt>Also known as</dt>
|
||
<dd>DRB3; HLA-DPB1; HLA-DR1B; HLA-DR3B; HLA-DRB3*</dd>
|
||
<dt>Summary</dt>
|
||
<dd>HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. There are multiple pseudogenes of this gene. [provided by RefSeq, Feb 2020]</dd>
|
||
<dt>Annotation information</dt>
|
||
<dd>Annotation category: only annotated on alternate loci in reference assembly</dd>
|
||
<dt style="padding-top:.5em;">
|
||
<span class="new-icon">NEW</span>
|
||
</dt>
|
||
<dd style="padding-top:.5em;">
|
||
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/3125/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="gene_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Gene table</a></strong>
|
||
<br />
|
||
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/3125/products/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="transcript_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Transcript table</a></strong>
|
||
</dd>
|
||
</dl>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-genomic-context">
|
||
<section class="rprt-section-header" id="genomic-context">
|
||
<h2 id="header-genomic-context">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-context .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Genomic context</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Genomic_Context" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div class="gc_cont">
|
||
<div class="gt_cont_contents">
|
||
<div style="float:right"><span>See HLA-DRB3 in </span><a href="/genome/gdv/?context=gene&acc=3125" class="link-to-gdv genome-browser-link" data-genome-browser-link-sort="1" data-acc="GCF_009914755.1">Genome Data Viewer</a> </div>
|
||
<dl class="dl-chr-info" style="float:left;margin-top:0;">
|
||
<dt>Location: </dt>
|
||
<dd>
|
||
<span style="display:inline-block;">6p21.3</span>
|
||
</dd>
|
||
</dl>
|
||
</div>
|
||
<dl class="dl-chr-info exon-count">
|
||
<dt>Exon count: </dt>
|
||
<dd>6</dd>
|
||
</dl>
|
||
<div class="ui-ncbigrid-outer-div" id="genomic-context-tbl-location">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-jigconfig="">
|
||
<thead>
|
||
<tr>
|
||
<th style="max-width:15%">Annotation release</th>
|
||
<th style="max-width:10%">Status</th>
|
||
<th>Assembly</th>
|
||
<th>
|
||
<span title="Chromosome">Chr</span>
|
||
</th>
|
||
<th>Location</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td>RS_2024_08</td>
|
||
<td>current</td>
|
||
<td>GRCh38.p14 (<a href="/assembly/GCF_000001405.40/" ref="ncbi_uid=3125&link_uid=GCF_000001405.40">GCF_000001405.40</a>)</td>
|
||
<td>6 (ALT_REF_LOCI_2)</td>
|
||
<td>NT_113891.3 (3934018..3947156, complement) </td>
|
||
</tr>
|
||
<tr>
|
||
<td>RS_2024_08</td>
|
||
<td>current</td>
|
||
<td>GRCh38.p14 (<a href="/assembly/GCF_000001405.40/" ref="ncbi_uid=3125&link_uid=GCF_000001405.40">GCF_000001405.40</a>)</td>
|
||
<td>6 (ALT_REF_LOCI_1)</td>
|
||
<td>NT_167244.2 (3824508..3837642, complement) </td>
|
||
</tr>
|
||
<tr>
|
||
<td>RS_2024_08</td>
|
||
<td>current</td>
|
||
<td>GRCh38.p14 (<a href="/assembly/GCF_000001405.40/" ref="ncbi_uid=3125&link_uid=GCF_000001405.40">GCF_000001405.40</a>)</td>
|
||
<td>6 (ALT_REF_LOCI_6)</td>
|
||
<td>NT_167248.2 (3715352..3728489, complement) </td>
|
||
</tr>
|
||
<tr>
|
||
<td>RS_2024_08</td>
|
||
<td>current</td>
|
||
<td>T2T-CHM13v2.0 (<a href="/assembly/GCF_009914755.1/" ref="ncbi_uid=3125&link_uid=GCF_009914755.1">GCF_009914755.1</a>)</td>
|
||
<td>6</td>
|
||
<td>NC_060930.1 (32345227..32358367, complement) </td>
|
||
</tr>
|
||
<tr>
|
||
<td>RS_2024_09</td>
|
||
<td>previous assembly</td>
|
||
<td>GRCh37.p13 (<a href="/assembly/GCF_000001405.25/" ref="ncbi_uid=3125&link_uid=GCF_000001405.25">GCF_000001405.25</a>)</td>
|
||
<td>6 Unlocalized Scaffold (ALT_REF_LOCI_2)</td>
|
||
<td>NT_113891.2 (3934124..3947262, complement) </td>
|
||
</tr>
|
||
<tr>
|
||
<td>RS_2024_09</td>
|
||
<td>previous assembly</td>
|
||
<td>GRCh37.p13 (<a href="/assembly/GCF_000001405.25/" ref="ncbi_uid=3125&link_uid=GCF_000001405.25">GCF_000001405.25</a>)</td>
|
||
<td>6 Unlocalized Scaffold (ALT_REF_LOCI_1)</td>
|
||
<td>NT_167244.1 (3774424..3787558, complement) </td>
|
||
</tr>
|
||
<tr>
|
||
<td>RS_2024_09</td>
|
||
<td>previous assembly</td>
|
||
<td>GRCh37.p13 (<a href="/assembly/GCF_000001405.25/" ref="ncbi_uid=3125&link_uid=GCF_000001405.25">GCF_000001405.25</a>)</td>
|
||
<td>6 Unlocalized Scaffold (ALT_REF_LOCI_6)</td>
|
||
<td>NT_167248.1 (3720948..3734085, complement) </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<p class="withnote margin_t2em"><strong>NT_167244.2</strong><img usemap="#nbrMap3125_568815454" border="0" alt="Genomic Context describing neighboring genes" src="/gutils/geneneighb.fcgi?geneid=3125&nuc_gi=568815454&n0=TSBP1-AS1&n1=HCG23&n2=BTNL2&n3=LOC127405865&n4=LOC129389490&n5=LOC124905341&n6=HLA-DRB3&n7=LOC128772279&n8=LOC102725019&n9=HLA-DQA2" /><map name="nbrMap3125_568815454" id="nbrMap3125_568815454">
|
||
<area shape="rect" onMouseOver="showtip(this,event,'TSBP1 and BTNL2 antisense RNA 1')" onMouseOut="hidetip()" coords="17,23,131,31" alt="Neighboring gene TSBP1 and BTNL2 antisense RNA 1" href="/gene/101929163" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'HLA complex group 23')" onMouseOut="hidetip()" coords="87,35,122,43" alt="Neighboring gene HLA complex group 23" href="/gene/414764" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'butyrophilin like 2')" onMouseOut="hidetip()" coords="90,47,130,55" alt="Neighboring gene butyrophilin like 2" href="/gene/56244" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr6:32427819-32428319')" onMouseOut="hidetip()" coords="117,59,187,67" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:32427819-32428319" href="/gene/127405865" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'MPRA-validated peak5756 silencer')" onMouseOut="hidetip()" coords="120,71,190,79" alt="Neighboring gene MPRA-validated peak5756 silencer" href="/gene/129389490" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'uncharacterized LOC124905341')" onMouseOut="hidetip()" coords="145,23,215,31" alt="Neighboring gene uncharacterized LOC124905341" href="/gene/124905341" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'melanoma risk locus-associated MPRA allelic enhancer 6:32685380')" onMouseOut="hidetip()" coords="333,23,403,31" alt="Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 6:32685380" href="/gene/128772279" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'uncharacterized LOC102725019')" onMouseOut="hidetip()" coords="333,35,403,43" alt="Neighboring gene uncharacterized LOC102725019" href="/gene/102725019" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'major histocompatibility complex, class II, DQ alpha 2')" onMouseOut="hidetip()" coords="373,47,423,55" alt="Neighboring gene major histocompatibility complex, class II, DQ alpha 2" href="/gene/3118" />
|
||
</map>
|
||
</p>
|
||
<p class="withnote margin_t2em"><strong>NT_113891.3</strong><img usemap="#nbrMap3125_568815529" border="0" alt="Genomic Context describing neighboring genes" src="/gutils/geneneighb.fcgi?geneid=3125&nuc_gi=568815529&n0=HLA-DRB9&n1=LOC127405865&n2=RNU1-79P&n3=HLA-DRB3&n4=HLA-DRB2&n5=RNU1-116P" /><map name="nbrMap3125_568815529" id="nbrMap3125_568815529">
|
||
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr6:32427819-32428319')" onMouseOut="hidetip()" coords="3,23,73,31" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:32427819-32428319" href="/gene/127405865" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'major histocompatibility complex, class II, DR beta 9 (pseudogene)')" onMouseOut="hidetip()" coords="22,35,72,43" alt="Neighboring gene major histocompatibility complex, class II, DR beta 9 (pseudogene)" href="/gene/3132" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'RNA, U1 small nuclear 79, pseudogene')" onMouseOut="hidetip()" coords="145,23,195,31" alt="Neighboring gene RNA, U1 small nuclear 79, pseudogene" href="/gene/107521942" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'major histocompatibility complex, class II, DR beta 2 (pseudogene)')" onMouseOut="hidetip()" coords="295,23,394,31" alt="Neighboring gene major histocompatibility complex, class II, DR beta 2 (pseudogene)" href="/gene/3124" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'RNA, U1 small nuclear 116, pseudogene')" onMouseOut="hidetip()" coords="368,35,423,43" alt="Neighboring gene RNA, U1 small nuclear 116, pseudogene" href="/gene/107521946" />
|
||
</map>
|
||
</p>
|
||
<p class="withnote margin_t2em"><strong>NT_167248.2</strong><img usemap="#nbrMap3125_568815567" border="0" alt="Genomic Context describing neighboring genes" src="/gutils/geneneighb.fcgi?geneid=3125&nuc_gi=568815567&n0=HLA-DRA&n1=LOC127405865&n2=LOC129389490&n3=LOC124905397&n4=HLA-DRB3&n5=HLA-DRB2&n6=RNU1-116P" /><map name="nbrMap3125_568815567" id="nbrMap3125_568815567">
|
||
<area shape="rect" onMouseOver="showtip(this,event,'major histocompatibility complex, class II, DR alpha')" onMouseOut="hidetip()" coords="27,23,80,31" alt="Neighboring gene major histocompatibility complex, class II, DR alpha" href="/gene/3122" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr6:32427819-32428319')" onMouseOut="hidetip()" coords="66,35,136,43" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:32427819-32428319" href="/gene/127405865" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'MPRA-validated peak5756 silencer')" onMouseOut="hidetip()" coords="74,47,144,55" alt="Neighboring gene MPRA-validated peak5756 silencer" href="/gene/129389490" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'uncharacterized LOC124905397')" onMouseOut="hidetip()" coords="159,23,229,31" alt="Neighboring gene uncharacterized LOC124905397" href="/gene/124905397" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'major histocompatibility complex, class II, DR beta 2 (pseudogene)')" onMouseOut="hidetip()" coords="307,23,398,31" alt="Neighboring gene major histocompatibility complex, class II, DR beta 2 (pseudogene)" href="/gene/3124" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'RNA, U1 small nuclear 116, pseudogene')" onMouseOut="hidetip()" coords="368,35,423,43" alt="Neighboring gene RNA, U1 small nuclear 116, pseudogene" href="/gene/107521946" />
|
||
</map>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-genomic-regions-transcripts-products">
|
||
<section class="rprt-section-header" id="genomic-regions-transcripts-products">
|
||
<h2 id="header-genomic-regions-transcripts-products">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-regions-transcripts-products .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Genomic regions, transcripts, and products</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Genomic_Regions_Transcripts_a" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div>
|
||
<div style="text-align:right;">Go to <a href="#reference-sequences">reference sequence details</a></div>
|
||
</div>
|
||
<div>
|
||
<p class="choose">
|
||
<label for="accession" class="label">Genomic Sequence: </label>
|
||
<select name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.accessionList" sid="1" id="accessionList" data-taxid="9606" data-geneid="3125">
|
||
<option value="NT_167244.2_3824507_3837641">NT_167244.2 Chromosome 6 Reference GRCh38.p14 ALT_REF_LOCI_1</option>
|
||
<option value="NT_113891.3_3934017_3947155">NT_113891.3 Chromosome 6 Reference GRCh38.p14 ALT_REF_LOCI_2</option>
|
||
<option value="NT_167248.2_3715351_3728488">NT_167248.2 Chromosome 6 Reference GRCh38.p14 ALT_REF_LOCI_6</option>
|
||
<option value="NC_060930.1_32345226_32358366">NC_060930.1 Chromosome 6 Alternate T2T-CHM13v2.0</option>
|
||
<option value="NT_113891.2_3934123_3947261">NT_113891.2 Chromosome 6 Unlocalized Scaffold Reference GRCh37.p13 ALT_REF_LOCI_2</option>
|
||
<option value="NT_167244.1_3774423_3787557">NT_167244.1 Chromosome 6 Unlocalized Scaffold Reference GRCh37.p13 ALT_REF_LOCI_1</option>
|
||
<option value="NT_167248.1_3720947_3734084">NT_167248.1 Chromosome 6 Unlocalized Scaffold Reference GRCh37.p13 ALT_REF_LOCI_6</option>
|
||
</select>
|
||
</p>
|
||
</div>
|
||
<div id="NT_167244" class="divAccession">
|
||
<div class="seq-viewer">
|
||
<p class="note-link">
|
||
<strong>Go to nucleotide:</strong>
|
||
<a title="Nucleotide Graphic report" href="/nuccore/NT_167244.2?report=graph&from=3822537&to=3839611&strand=true&app_context=Gene&assm_context=GCF_000001405.40" ref="ordinalpos=1&ncbi_uid=3125&link_uid=NT_167244.2">Graphics</a>
|
||
<a title="Nucleotide FASTA report" href="/nuccore/NT_167244.2?report=fasta&from=3824508&to=3837642&strand=true" ref="ordinalpos=1&ncbi_uid=3125&link_uid=NT_167244.2">FASTA</a>
|
||
<a title="Nucleotide GenBank report" href="/nuccore/NT_167244.2?report=genbank&from=3824508&to=3837642&strand=true" ref="ordinalpos=1&ncbi_uid=3125&link_uid=NT_167244.2">GenBank</a>
|
||
</p>
|
||
<div id="divNT_167244" class="SeqViewerApp" style="clear:both;" data-sv="appname=ncbigene&embedded=true&noslider=1&id=NT_167244.2&from=3822537&to=3839611&strand=true&app_context=Gene&assm_context=GCF_000001405.40">
|
||
<a href="?appname=ncbigene&embedded=true&noslider=1&id=NT_167244.2&from=3822537&to=3839611&strand=true&app_context=Gene&assm_context=GCF_000001405.40"></a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NT_167244.2" sid="1" type="hidden" id="nucleotideLink_NT_167244_2_3824507_3837641" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NT_167244.2?report=graph&amp;from=3822537&amp;to=3839611&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" ref="ordinalpos=1&amp;ncbi_uid=3125&amp;link_uid=NT_167244.2">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NT_167244.2?report=fasta&amp;from=3824508&amp;to=3837642&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=3125&amp;link_uid=NT_167244.2">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NT_167244.2?report=genbank&amp;from=3824508&amp;to=3837642&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=3125&amp;link_uid=NT_167244.2">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NT_167244.2" sid="1" type="hidden" id="relString_NT_167244_2_3824507_3837641" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NT_167244.2&amp;from=3822537&amp;to=3839611&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NT_113891.3" sid="1" type="hidden" id="nucleotideLink_NT_113891_3_3934017_3947155" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NT_113891.3?report=graph&amp;from=3932046&amp;to=3949126&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" ref="ordinalpos=1&amp;ncbi_uid=3125&amp;link_uid=NT_113891.3">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NT_113891.3?report=fasta&amp;from=3934018&amp;to=3947156&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=3125&amp;link_uid=NT_113891.3">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NT_113891.3?report=genbank&amp;from=3934018&amp;to=3947156&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=3125&amp;link_uid=NT_113891.3">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NT_113891.3" sid="1" type="hidden" id="relString_NT_113891_3_3934017_3947155" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NT_113891.3&amp;from=3932046&amp;to=3949126&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NT_167248.2" sid="1" type="hidden" id="nucleotideLink_NT_167248_2_3715351_3728488" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NT_167248.2?report=graph&amp;from=3713380&amp;to=3730459&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" ref="ordinalpos=1&amp;ncbi_uid=3125&amp;link_uid=NT_167248.2">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NT_167248.2?report=fasta&amp;from=3715352&amp;to=3728489&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=3125&amp;link_uid=NT_167248.2">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NT_167248.2?report=genbank&amp;from=3715352&amp;to=3728489&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=3125&amp;link_uid=NT_167248.2">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NT_167248.2" sid="1" type="hidden" id="relString_NT_167248_2_3715351_3728488" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NT_167248.2&amp;from=3713380&amp;to=3730459&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_060930.1" sid="1" type="hidden" id="nucleotideLink_NC_060930_1_32345226_32358366" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NC_060930.1?report=graph&amp;from=32343255&amp;to=32360337&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_009914755.1" ref="ordinalpos=1&amp;ncbi_uid=3125&amp;link_uid=NC_060930.1">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NC_060930.1?report=fasta&amp;from=32345227&amp;to=32358367&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=3125&amp;link_uid=NC_060930.1">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NC_060930.1?report=genbank&amp;from=32345227&amp;to=32358367&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=3125&amp;link_uid=NC_060930.1">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_060930.1" sid="1" type="hidden" id="relString_NC_060930_1_32345226_32358366" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_060930.1&amp;from=32343255&amp;to=32360337&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_009914755.1" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NT_113891.2" sid="1" type="hidden" id="nucleotideLink_NT_113891_2_3934123_3947261" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NT_113891.2?report=graph&amp;from=3932152&amp;to=3949232&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.25" ref="ordinalpos=1&amp;ncbi_uid=3125&amp;link_uid=NT_113891.2">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NT_113891.2?report=fasta&amp;from=3934124&amp;to=3947262&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=3125&amp;link_uid=NT_113891.2">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NT_113891.2?report=genbank&amp;from=3934124&amp;to=3947262&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=3125&amp;link_uid=NT_113891.2">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NT_113891.2" sid="1" type="hidden" id="relString_NT_113891_2_3934123_3947261" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NT_113891.2&amp;from=3932152&amp;to=3949232&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.25" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NT_167244.1" sid="1" type="hidden" id="nucleotideLink_NT_167244_1_3774423_3787557" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NT_167244.1?report=graph&amp;from=3772453&amp;to=3789527&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.25" ref="ordinalpos=1&amp;ncbi_uid=3125&amp;link_uid=NT_167244.1">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NT_167244.1?report=fasta&amp;from=3774424&amp;to=3787558&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=3125&amp;link_uid=NT_167244.1">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NT_167244.1?report=genbank&amp;from=3774424&amp;to=3787558&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=3125&amp;link_uid=NT_167244.1">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NT_167244.1" sid="1" type="hidden" id="relString_NT_167244_1_3774423_3787557" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NT_167244.1&amp;from=3772453&amp;to=3789527&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.25" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NT_167248.1" sid="1" type="hidden" id="nucleotideLink_NT_167248_1_3720947_3734084" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NT_167248.1?report=graph&amp;from=3718976&amp;to=3736055&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.25" ref="ordinalpos=1&amp;ncbi_uid=3125&amp;link_uid=NT_167248.1">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NT_167248.1?report=fasta&amp;from=3720948&amp;to=3734085&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=3125&amp;link_uid=NT_167248.1">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NT_167248.1?report=genbank&amp;from=3720948&amp;to=3734085&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=3125&amp;link_uid=NT_167248.1">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NT_167248.1" sid="1" type="hidden" id="relString_NT_167248_1_3720947_3734084" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NT_167248.1&amp;from=3718976&amp;to=3736055&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.25" />
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div class="rprt-section gene-bibliography">
|
||
<section class="rprt-section-header" id="bibliography"><h2 id="header-bibliography"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-bibliography .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Bibliography</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Bibliography" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
|
||
<div class="rprt-section-body" style="">
|
||
<div class="generif-pubmed">
|
||
<h3 id="relatedarticlesinpubmed">
|
||
<a href="#" class="jig-ncbitoggler-open">Related articles in PubMed</a>
|
||
</h3>
|
||
<div class="generefbl-link">
|
||
<ol class="generef-link">
|
||
<li>
|
||
<a href="/pubmed/23462545/" ref="ordinalpos=1&ncbi_uid=3125&link_uid=23462545">Next generation sequencing reveals the association of DRB3*02:02 with type 1 diabetes.</a>
|
||
<span class="pubmed-auth-date"> Erlich HA, <em>et al</em>. Diabetes, 2013 Jul. PMID 23462545, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC3712046/" ref="ordinalpos=0&ncbi_uid=3125&link_uid=PMC3712046">Free PMC Article</a></span></span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/6414998/" ref="ordinalpos=2&ncbi_uid=3125&link_uid=6414998">Molecular analysis of the genes for human class II antigens of the major histocompatibility complex.</a>
|
||
<span class="pubmed-auth-date"> Long EO, <em>et al</em>. Hum Immunol, 1983 Sep. PMID 6414998</span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/19830726/" ref="ordinalpos=3&ncbi_uid=3125&link_uid=19830726">Reassessing the role of HLA-DRB3 T-cell responses: evidence for significant expression and complementary antigen presentation.</a>
|
||
<span class="pubmed-auth-date"> Faner R, <em>et al</em>. Eur J Immunol, 2010 Jan. PMID 19830726, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC2830809/" ref="ordinalpos=0&ncbi_uid=3125&link_uid=PMC2830809">Free PMC Article</a></span></span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/21507567/" ref="ordinalpos=4&ncbi_uid=3125&link_uid=21507567">The association of sporadic inclusion body myositis and Sjögren's syndrome in carriers of HLA-DR3 and the 8.1 MHC ancestral haplotype.</a>
|
||
<span class="pubmed-auth-date"> Rojana-udomsart A, <em>et al</em>. Clin Neurol Neurosurg, 2011 Sep. PMID 21507567</span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/19136661/" ref="ordinalpos=5&ncbi_uid=3125&link_uid=19136661">T-cell responses associated with neonatal alloimmune thrombocytopenia: isolation of HPA-1a-specific, HLA-DRB3*0101-restricted CD4+ T cells.</a>
|
||
<span class="pubmed-auth-date"> Ahlen MT, <em>et al</em>. Blood, 2009 Apr 16. PMID 19136661</span>
|
||
</li>
|
||
</ol>
|
||
<p class="see-all-pm">
|
||
<a href="/pubmed?LinkName=gene_pubmed&from_uid=3125" title="See all 212 citations in Pubmed">See all (212) citations in PubMed</a>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="generif-pubmed generif">
|
||
<h3 id="generifsgenereferencesintofunctions">
|
||
<a href="#" class="jig-ncbitoggler-open">GeneRIFs: Gene References Into Functions</a>
|
||
</h3>
|
||
<div>
|
||
<a href="/gene/about-generif" class="whatisthis">What's a GeneRIF?</a>
|
||
<div class="generefbl-link">
|
||
<ol class="generef-link">
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/36286990" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=3125&link_uid=36286990">Full genomic sequence of the HLA-DRB3*02:32 allele by Single Molecule Real-time Sequencing Technology.</a>
|
||
<div id="gene-popper1" class="gene-rif-popper">Title: Full genomic sequence of the HLA-DRB3*02:32 allele by Single Molecule Real-time Sequencing Technology.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/32462780" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=3125&link_uid=32462780">Characterization of the novel HLA-DRB3*02:02:25 allele by sequencing-based typing.</a>
|
||
<div id="gene-popper2" class="gene-rif-popper">Title: Characterization of the novel HLA-DRB3*02:02:25 allele by sequencing-based typing.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/33565267" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=3125&link_uid=33565267">Characterization of the novel HLA-DRB3*03:49 allele by sequencing-based typing.</a>
|
||
<div id="gene-popper3" class="gene-rif-popper">Title: Characterization of the novel HLA-DRB3*03:49 allele by sequencing-based typing.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/28019029" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=3125&link_uid=28019029">In contrast to HLA-DRB4*01:01P, the inheritance of HLA-DRB3*01:01 is strongly associated with the propensity for mounting a humoral immune response against fetal HPA-1a antigen.</a>
|
||
<div id="gene-popper4" class="gene-rif-popper">Title: HLA-DRB3*01:01 is a predictor of immunization against human platelet antigen-1a but not of the severity of fetal and neonatal alloimmune thrombocytopenia.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/28028136" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=3125&link_uid=28028136">our findings provide clear evidence that the HLA-DRB1*15:01 and HLA-DRB3*02:02 alleles independently and strongly associate with phospholipase A2 receptor related idiopathic membranous nephropathy in the Chinese population</a>
|
||
<div id="gene-popper5" class="gene-rif-popper">Title: HLA-DRB1*15:01 and HLA-DRB3*02:02 in PLA2R-Related Membranous Nephropathy.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/27181214" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=3125&link_uid=27181214">The first time that the haplotypes A33-DR3 and A33-DR9 were found with an enhanced predisposition to type 1 diabetes in Han Chinese.</a>
|
||
<div id="gene-popper6" class="gene-rif-popper">Title: HLA-A*33-DR3 and A*33-DR9 haplotypes enhance the risk of type 1 diabetes in Han Chinese.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/26740600" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=3125&link_uid=26740600">HLA-DRB3 affects type 1 diabetes risk and islet autoantibodies.</a>
|
||
<div id="gene-popper7" class="gene-rif-popper">Title: Next-Generation Sequencing Reveals That HLA-DRB3, -DRB4, and -DRB5 May Be Associated With Islet Autoantibodies and Risk for Childhood Type 1 Diabetes.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/26475924" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=3125&link_uid=26475924">this mouse model unravels a critical role for HLA-DR3 in generating an autoimmune response to SmD and lupus nephritis in the NZM2328 background.</a>
|
||
<div id="gene-popper8" class="gene-rif-popper">Title: A Central Role for HLA-DR3 in Anti-Smith Antibody Responses and Glomerulonephritis in a Transgenic Mouse Model of Spontaneous Lupus.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/24628273" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=3125&link_uid=24628273">Haplotyping was done on 91 Southern Europe celiac patients. HLA-DR3-DQ2 without HLA-DR7-DQ2 was present in 62.6%, HLA-DR7-DQ2 without HLA-DR3-DQ2 was present in 16.5% and HLA-DR4-DQ8 without HLA-DQ2 was present in 3.3%.</a>
|
||
<div id="gene-popper9" class="gene-rif-popper">Title: Paediatric celiac patients carrying the HLA-DR7-DQ2 and HLA-DR3-DQ2 haplotypes display small clinical differences.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/24988556" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=3125&link_uid=24988556">Children with the HLA haplotype DR3-DQ2, especially homozygotes, were found to be at high risk for celiac disease autoimmunity and celiac disease early in childhood.</a>
|
||
<div id="gene-popper10" class="gene-rif-popper">Title: Risk of pediatric celiac disease according to HLA haplotype and country.</div>
|
||
</li>
|
||
</ol>
|
||
</div>
|
||
<div class="submit-genrif">
|
||
<span>Submit:</span>
|
||
<a href="/gene/submit-generif/?geneId=3125&sym=HLA-DRB3&name=major histocompatibility complex, class II, DR beta 3&org=Homo sapiens">New GeneRIF</a>
|
||
<a href="/RefSeq/update.cgi?geneid=3125&symbol=HLA-DRB3;task=fixpub">Correction</a>
|
||
<a href="https://www.ncbi.nlm.nih.gov/gene?db=gene&report=generif&term=3125" class="seeall-generif">See all GeneRIFs (46)</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-phenotypes">
|
||
<section class="rprt-section-header" id="phenotypes">
|
||
<h2 id="header-phenotypes">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-phenotypes .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Phenotypes</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Phenotype" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body info-phenotype">
|
||
<p class="nochild-link">
|
||
<a href="/gtr/tests/?term=HLA-DRB3[gene]">Find tests for this gene in the NIH Genetic Testing Registry (GTR)</a>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-variation">
|
||
<section class="rprt-section-header" id="variation">
|
||
<h2 id="header-variation">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-variation .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Variation</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.variation" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<p class="nochild-link">
|
||
<a href="/dbvar?LinkName=gene_dbvar&from_uid=3125" ref="log$=recordlinks">See studies and variants in dbVar</a>
|
||
</p>
|
||
<p class="nochild-link">
|
||
<a href="/variation/view/?q=3125[geneid]&assm=GCF_000001405.25" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh37.p13)">See Variation Viewer (GRCh37.p13)</a>
|
||
</p>
|
||
<p class="nochild-link">
|
||
<a href="/variation/view/?q=3125[geneid]" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh38)">See Variation Viewer (GRCh38)</a>
|
||
</p>
|
||
<set></set>
|
||
<set></set>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-HIV-1-interactions">
|
||
<section class="rprt-section-header" id="HIV-1-interactions">
|
||
<h2 id="header-HIV-1-interactions">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-HIV-1-interactions .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">HIV-1 interactions</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.HIV1_interactions" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div class="fgrid">
|
||
<h3 id="proteininteractions">Protein interactions</h3>
|
||
<table summary="protein interactions" class="jig-ncbigrid">
|
||
<thead>
|
||
<tr>
|
||
<th id="hivprotein">Protein</th>
|
||
<th id="gene-hivprotein">Gene</th>
|
||
<th id="hivinter">Interaction</th>
|
||
<th id="hivpub">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/28876544">Envelope surface glycoprotein gp120</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CD4-mediated endocytosis of HIV-1 gp120 results in MHC-II (HLA-DR) presentation to CD4+ T cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23729440" href="/pubmed/23729440">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CD4+ T cells infected with CCR5-tropic HIV-1 have significantly higher levels of activation-marker expression (e.g. CD25, CD71 and HLA-DR) than CD4+ T lymphocytes infected with CXCR4-tropic HIV-1</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 15784911" href="/pubmed/15784911">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV envelope protein gp120 can specifically inhibit CD4-dependent class II MHC-restricted T cell response to Ag</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 8168144,7734415,7541827,2846691,2543930" href="/pubmed/8168144,7734415,7541827,2846691,2543930">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Genetic variability in HIV-1 gp120 affects its interactions with HLA-DR molecules and T cell receptor</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 12427289,7645219,1970352" href="/pubmed/12427289,7645219,1970352">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Amino acid residues 42-49 in the V1 region of CD4 are involved in the interaction between HIV-1 gp120 and class II major histocompatibility complex molecules</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 7512597,1978941,1967269,1869305" href="/pubmed/7512597,1978941,1967269,1869305">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/9629363">Envelope surface glycoprotein gp160, precursor</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Processing of HIV-1 gp160 to gp120 and gp41 is necessary for the association of HIV-1 envelope glycoproteins with class II MHC</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 9079699,8376762,7602119,3489470" href="/pubmed/9079699,8376762,7602119,3489470">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Antibodies against cell surface molecules LFA-1, ICAM-1, HLA-DR, and CD28 inhibit the HIV-1 gp160-induced B cell differentiation response; gp160 also induces IL-6R and CD23 molecule expression on B cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 8450224" href="/pubmed/8450224">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/19172954">Envelope transmembrane glycoprotein gp41</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Soluble HIV-1 gp41 can selectively enhance MHC class I and II expression on human B cells, but does not increase expression of other cell surface antigens such as CD21 and CD54 (ICAM-1)</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 8084338" href="/pubmed/8084338">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Soluble HIV-1 gp41 enhancement effects on MHC class I and II antigen expression can be inhibited by soluble gp41-binding proteins of 45, 49 and 62 kD from human B cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 8084338" href="/pubmed/8084338">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">A 43-amino-acid sequence between amino acids 708 and 750 in the HIV-1 gp41(TM) cytoplasmic tail is required for efficient incorporation of HLA class II proteins into virions</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 10729169" href="/pubmed/10729169">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/28872818">Nef</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef impairs IL-4/GM-CSF-stimulated THP-1 differentiation towards immature DCs, which leads to the lower levels of CD11C, CD40, and HLA-DR protein expression from the cell surface</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22808111" href="/pubmed/22808111">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">Four large regions (residues 1-36, 66-97, 117-147, and 182-205) of HIV-1 Nef bind efficiently to eight HLA-DR molecules</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 17411376" href="/pubmed/17411376">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef-pulsed mDCs downregulate HLA-DR expression and upregulate CD25 and CCR7 expression in NK cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21922073,19770068,19449444,17431094" href="/pubmed/21922073,19770068,19449444,17431094">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">Nef-triggered MHCII endocytosis requires Rab5 activity and lyst function, whereas lysosomal trafficking of internalized MHCII molecules requires Rab7 activity</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 19620308" href="/pubmed/19620308">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/9629360">Pr55(Gag)</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">Expression of CD80, CD83, CD86, and HLA-DR molecules are significantly downregulated in mature dendritic cells after transduction with ubiquitinated Gag compared to unubiquitinated Gag constructs</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24505475" href="/pubmed/24505475">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">Two peptides of the CA domain of HIV-1 Gag, VDRFYKTLRAEQASQ and DRFYKLTRAEQASQ, are presented on MHC II molecules of dendritic cells and have similar sensitivity for antigen-specific T cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22860026" href="/pubmed/22860026">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">Expression of MARCH-8 inhibits HLA-DR-mediated enhancement of mature Gag products internalization by downregulating cell surface HLA-DR</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23170932" href="/pubmed/23170932">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">The Gag late-budding domain PTAP motif and the cytosolic tails of the HLA-DR alpha and beta chains are required for HLA-DR-mediated Gag accumulation in late endosomal/multivesicular bodies (LE/MVB)</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23170932" href="/pubmed/23170932">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">Dynamin-dependent endocytosis is required for intracellular accumulation of HIV-1 Gag in presence of HLA-DR</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23170932" href="/pubmed/23170932">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Gag virus-like particles efficiently activate human monocyte-derived dendritic cells (MDDC) and induce MDDC maturation with an associated increase in the surface expression of CD80, CD86 and MHC classes I and II</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21778700" href="/pubmed/21778700">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">Human Leukocyte Antigen DR (HLA-DR), Major Histocompatibility Complex class II molecules (MHC-II) induce a relocation of Gag to late endosomal/multivesicular bodies (LE/MVB) and increase the accumulation of viral particles assembling intracellularly</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23170932,17507489,16973583" href="/pubmed/23170932,17507489,16973583">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Gag virus-like particle-induced monocyte activation is shown by upregulation of molecules involved in antigen presentation (MHC II, CD80, CD86) and cell adhesion (CD54)</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 18945465" href="/pubmed/18945465">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Gag expression is able to induce HLA-DR cell-surface localization in H78-C10.0 cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 12202216" href="/pubmed/12202216">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">In human macrophages, HIV-1 Gag proteins co-localize with MHC II (HLA-DR), CD63, and Lamp1 in MHC II compartments</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23170932,12230470" href="/pubmed/23170932,12230470">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/9629358">Tat</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">Treatment of PBMCs with HIV-1 Tat significantly enhances the generation of monocytic myeloid-derived suppressor cells expressing no or very low levels of HLA-DR</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23152536" href="/pubmed/23152536">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Tat upregulates HLA-DR expression in monocyte-derived dendritic cells and T cells, thereby driving T cell-mediated immune responses and activation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21085635,11751963,9223324" href="/pubmed/21085635,11751963,9223324">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Tat downregulates expression of MHC class II genes in antigen-presenting cells (APC) by inhibiting the transactivator of MHC class II genes, CIITA</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 11118314,10661406" href="/pubmed/11118314,10661406">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/9629366">Vpu</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155945">vpu</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpu interacts with CD74 and modulates MHC II in HIV-1-infected cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20012522,18672082,17959659" href="/pubmed/20012522,18672082,17959659">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/19172948">capsid</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 CA co-localizes with HLA-DR in human monocyte-derived dendritic cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25240755" href="/pubmed/25240755">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Capsid (p24) inhibits interferon gamma induced increases in HLA-DR and cytochrome B heavy chain mRNA levels in the human monocyte-like cell line THP1</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 1905983" href="/pubmed/1905983">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
<p class="withnote">
|
||
<a class="note" href="/genome/viruses/retroviruses/hiv-1/interactions/">Go to the HIV-1, Human Interaction Database </a>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-pathways">
|
||
<section class="rprt-section-header" id="pathways">
|
||
<h2 id="header-pathways">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-pathways .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Pathways from PubChem</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<ul class="geneinfo-subsec infopathway">
|
||
<iframe title="Pathways in which the gene target is involved" class="pubchem-widget" scrolling="no" src="https://pubchem.ncbi.nlm.nih.gov/gene/3125#section=Pathways&embed=true&hide_all_headings=true&page_size=25" style="border: 0; width: 100%;"></iframe>
|
||
<script type="text/javascript" src="https://pubchem.ncbi.nlm.nih.gov/pcfe/libs/iframeResizer.min.js"></script>
|
||
<script type="text/javascript">iFrameResize({log: false, checkOrigin: false}, '.pubchem-widget')</script>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-interactions">
|
||
<section class="rprt-section-header" id="interactions">
|
||
<h2 id="header-interactions">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-interactions .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Interactions</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Interactions" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<table summary="Gene Interaction" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/3125/data/interaction/',webserviceParams: 'p$l=Ajax&p$debugoutput=off', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
|
||
<thead>
|
||
<tr>
|
||
<th id="inter-prod">Products</th>
|
||
<th id="inter-interactant">Interactant</th>
|
||
<th id="inter-otherGene">Other Gene</th>
|
||
<th id="inter-compl">Complex</th>
|
||
<th id="inter-source">Source</th>
|
||
<th id="inter-pubs">Pubs</th>
|
||
<th id="inter-desc">Description</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody></tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-general-gene-info">
|
||
<section class="rprt-section-header" id="general-gene-info">
|
||
<h2 id="header-general-gene-info">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-gene-info .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">General gene information</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.General_Gene_Information" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
|
||
<div class="rprt-section-body" style="">
|
||
<div id="gene-markers">
|
||
<h3 id="markers">
|
||
<a class="jig-ncbitoggler">Markers</a>
|
||
</h3>
|
||
<div>
|
||
<ul class="marker odd">
|
||
<li class="marker">GDB:177509 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=154904%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=3125&link_uid=154904">UniSTS:154904</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">RH69063 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=91672%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=3125&link_uid=91672">UniSTS:91672</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">RH69092 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=86556%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=3125&link_uid=86556">UniSTS:86556</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">RH80065 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=88606%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=3125&link_uid=88606">UniSTS:88606</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">RH69107 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=85025%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=3125&link_uid=85025">UniSTS:85025</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">RH46825 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=24120%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=3125&link_uid=24120">UniSTS:24120</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">STS-V00522 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=68941%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=3125&link_uid=68941">UniSTS:68941</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">NoName (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=487006%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=3125&link_uid=487006">UniSTS:487006</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">RH79846 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=85123%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=3125&link_uid=85123">UniSTS:85123</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">RH46799 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=54689%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=3125&link_uid=54689">UniSTS:54689</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">RH15772 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=7126%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=3125&link_uid=7126">UniSTS:7126</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">RH69091 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=25841%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=3125&link_uid=25841">UniSTS:25841</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">RH80800 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=92913%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=3125&link_uid=92913">UniSTS:92913</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">RH70404 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=86775%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=3125&link_uid=86775">UniSTS:86775</a></li></ul></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div></div>
|
||
|
||
|
||
<!--<component id="Gene_InfoPathway"/>-->
|
||
|
||
<div class="infosec info-comment" id="info-comment">
|
||
<h3 id="CloneNames">
|
||
<a class="jig-ncbitoggler-open">Clone Names</a>
|
||
</h3>
|
||
<ul class="geneinfo-subsec">
|
||
<li>MGC117330 </li>
|
||
</ul>
|
||
</div>
|
||
|
||
<div class="gene-ontology infosec">
|
||
<h3 id="gene-ontology">
|
||
<a class="jig-ncbitoggler-open">
|
||
<span>Gene Ontology</span>
|
||
</a>
|
||
<a target="_blank" href="http://www.ebi.ac.uk/GOA" class="g-ontology-src" title="Provided by GOA">Provided by GOA</a>
|
||
</h3>
|
||
<div class="ontology-tables">
|
||
<div class="ui-ncbigrid-outer-div">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
|
||
<thead>
|
||
<tr>
|
||
<th class="col1">Function</th>
|
||
<th style="width:12%;">Evidence Code</th>
|
||
<th style="width:10%;">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0023026">enables MHC class II protein complex binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-1-0" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0032395">enables MHC class II receptor activity</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> NAS</a>
|
||
<div id="evidence-code-2-0" class="ecode">Non-traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/6414998" target="_blank" title="PubMed ID 6414998" ref="ordinalpos=1&ncbi_uid=3125&link_uid=6414998">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0042605">enables peptide antigen binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-3-0" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0042605">enables peptide antigen binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-4-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/17583734,18697946" target="_blank" title="PubMed ID 17583734,18697946" ref="ordinalpos=1&ncbi_uid=3125&link_uid=17583734,18697946">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0042605">enables peptide antigen binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
|
||
<div id="evidence-code-5-0" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/20356827" target="_blank" title="PubMed ID 20356827" ref="ordinalpos=1&ncbi_uid=3125&link_uid=20356827">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005515">enables protein binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
|
||
<div id="evidence-code-6-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/32814053" target="_blank" title="PubMed ID 32814053" ref="ordinalpos=1&ncbi_uid=3125&link_uid=32814053">PubMed</a> </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
<div class="ui-ncbigrid-outer-div">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
|
||
<thead>
|
||
<tr>
|
||
<th class="col1">Process</th>
|
||
<th style="width:12%;">Evidence Code</th>
|
||
<th style="width:10%;">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0050852">involved_in T cell receptor signaling pathway</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-1-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/32341563" target="_blank" title="PubMed ID 32341563" ref="ordinalpos=1&ncbi_uid=3125&link_uid=32341563">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0002250">involved_in adaptive immune response</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-2-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0019886">involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-3-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0019886">involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-4-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/19531622,32341563" target="_blank" title="PubMed ID 19531622,32341563" ref="ordinalpos=1&ncbi_uid=3125&link_uid=19531622,32341563">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0002469">involved_in myeloid dendritic cell antigen processing and presentation</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-5-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/19531622,30282837" target="_blank" title="PubMed ID 19531622,30282837" ref="ordinalpos=1&ncbi_uid=3125&link_uid=19531622,30282837">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0002503">involved_in peptide antigen assembly with MHC class II protein complex</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-6-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:2000516">involved_in positive regulation of CD4-positive, alpha-beta T cell activation</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-7-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/19531622" target="_blank" title="PubMed ID 19531622" ref="ordinalpos=1&ncbi_uid=3125&link_uid=19531622">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0050870">involved_in positive regulation of T cell activation</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-8-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0002842">involved_in positive regulation of T cell mediated immune response to tumor cell</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-9-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/30282837" target="_blank" title="PubMed ID 30282837" ref="ordinalpos=1&ncbi_uid=3125&link_uid=30282837">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0050778">involved_in positive regulation of immune response</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-10-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0007165">involved_in signal transduction</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> NAS</a>
|
||
<div id="evidence-code-11-1" class="ecode">Non-traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/8775462" target="_blank" title="PubMed ID 8775462" ref="ordinalpos=1&ncbi_uid=3125&link_uid=8775462">PubMed</a> </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
<div class="ui-ncbigrid-outer-div">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-config="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
|
||
<thead>
|
||
<tr>
|
||
<th class="col1">Component</th>
|
||
<th style="width:12%;">Evidence Code</th>
|
||
<th style="width:10%;">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0012507">located_in ER to Golgi transport vesicle membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-1-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0000139">located_in Golgi membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-2-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0042613">part_of MHC class II protein complex</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-3-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0042613">part_of MHC class II protein complex</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
|
||
<div id="evidence-code-4-2" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/20356827" target="_blank" title="PubMed ID 20356827" ref="ordinalpos=1&ncbi_uid=3125&link_uid=20356827">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0120281">located_in autolysosome membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-5-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0030669">located_in clathrin-coated endocytic vesicle membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-6-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0030666">located_in endocytic vesicle membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-7-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0031902">is_active_in late endosome membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-8-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0031902">located_in late endosome membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-9-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/18305173" target="_blank" title="PubMed ID 18305173" ref="ordinalpos=1&ncbi_uid=3125&link_uid=18305173">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0098553">located_in lumenal side of endoplasmic reticulum membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-10-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005765">is_active_in lysosomal membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-11-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005765">located_in lysosomal membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-12-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-12-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/18305173" target="_blank" title="PubMed ID 18305173" ref="ordinalpos=1&ncbi_uid=3125&link_uid=18305173">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005765">located_in lysosomal membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-13-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-13-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0016020">located_in membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-14-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> HDA</a>
|
||
<div id="evidence-code-14-2" class="ecode">
|
||
<br />
|
||
<a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a>
|
||
</div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/19946888" target="_blank" title="PubMed ID 19946888" ref="ordinalpos=1&ncbi_uid=3125&link_uid=19946888">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005886">located_in plasma membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-15-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-15-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/19531622" target="_blank" title="PubMed ID 19531622" ref="ordinalpos=1&ncbi_uid=3125&link_uid=19531622">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005886">located_in plasma membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-16-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> NAS</a>
|
||
<div id="evidence-code-16-2" class="ecode">Non-traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/6414998" target="_blank" title="PubMed ID 6414998" ref="ordinalpos=1&ncbi_uid=3125&link_uid=6414998">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005886">located_in plasma membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-17-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-17-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0032588">located_in trans-Golgi network membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-18-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-18-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0030658">located_in transport vesicle membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-19-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-19-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-general-protein-info">
|
||
<section class="rprt-section-header" id="general-protein-info">
|
||
<h2 id="header-general-protein-info">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-protein-info .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">General protein information</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.General_Protein_Information" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<dl>
|
||
<dt>Preferred Names</dt>
|
||
<dd>major histocompatibility complex, class II, DR beta 3</dd>
|
||
</dl>
|
||
<dl>
|
||
<dt>Names</dt>
|
||
<dd>HLA DRB3</dd>
|
||
<dd>HLA class II histocompatibility antigen, DR beta 3 chain</dd>
|
||
<dd>MHC class II DR beta chain</dd>
|
||
<dd>MHC class II HLA-DR beta 3 chain</dd>
|
||
<dd>MHC class II antigen DR beta 3 chain</dd>
|
||
<dd>MHC class II antigen DRB3</dd>
|
||
<dd>MHC class II protein</dd>
|
||
<dd>human leucocyte antigen DRB3</dd>
|
||
<dd>major histocompatibility complex, class II, DRB3</dd>
|
||
</dl>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-reference-sequences">
|
||
<section class="rprt-section-header" id="reference-sequences">
|
||
<h2 id="header-reference-sequences">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-reference-sequences .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">NCBI Reference Sequences (RefSeq)</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.NCBI_Reference_Sequences_RefS" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<p>
|
||
<span class="new-icon">NEW</span>
|
||
<strong>Try the new <a href="/datasets/tables/genes/?table_type=transcripts&ids=3125&utm_source=gene&utm_medium=referral&utm_campaign=refseq" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report." data-ga-category="refseq" data-ga-action="click_datasets_link" data-ga-label="transcript_table">Transcript table</a></strong>
|
||
</p>
|
||
<h3 class="genomerefseqs gene_std_toggler" id="refseqset-independent">
|
||
<a class="jig-ncbitoggler-open">RefSeqs maintained independently of Annotated
|
||
Genomes</a>
|
||
</h3>
|
||
<div class="genomerefseqs_slave">
|
||
<p class="desc"> These reference sequences exist independently of genome builds. <a href="#refseq-expl" id="expl-refseg">Explain</a></p>
|
||
<p id="refseq-expl"> These reference sequences are curated independently of the genome
|
||
annotation cycle, so their versions may not match the RefSeq versions in the current
|
||
genome build. Identify version mismatches by comparing the version of the RefSeq in
|
||
this section to the one reported in <a href="#geneGenomic regions, transcripts, and products">Genomic regions,
|
||
transcripts, and products</a> above. </p>
|
||
<h4 id="mrnaandproteins-p133153024">mRNA and Protein(s) </h4>
|
||
<ol>
|
||
<li>
|
||
<p><a href="/nuccore/NM_022555.4">NM_022555.4</a> → <a href="/protein/NP_072049.2">NP_072049.2</a> major histocompatibility complex, class II, DR beta 3 precursor</p>
|
||
<p>
|
||
<a href="/ipg/NP_072049.2/" ref="ncbi_uid=3125">See identical proteins and their annotated locations for NP_072049.2</a>
|
||
</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: VALIDATED</p>
|
||
<dl>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AL662842">AL662842</a>
|
||
</dd>
|
||
<dt>UniProtKB/Swiss-Prot</dt>
|
||
<dd><a href="https://www.uniprot.org/uniprot/A0ZXY9" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">A0ZXY9</a>, <a href="https://www.uniprot.org/uniprot/A7MA46" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">A7MA46</a>, <a href="https://www.uniprot.org/uniprot/B5AU12" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">B5AU12</a>, <a href="https://www.uniprot.org/uniprot/B5AU13" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">B5AU13</a>, <a href="https://www.uniprot.org/uniprot/B5AU14" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">B5AU14</a>, <a href="https://www.uniprot.org/uniprot/B8YAC6" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">B8YAC6</a>, <a href="https://www.uniprot.org/uniprot/C6H115" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">C6H115</a>, <a href="https://www.uniprot.org/uniprot/C6H116" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">C6H116</a>, <a href="https://www.uniprot.org/uniprot/O02875" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">O02875</a>, <a href="https://www.uniprot.org/uniprot/O19590" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">O19590</a>, <a href="https://www.uniprot.org/uniprot/O46701" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">O46701</a>, <a href="https://www.uniprot.org/uniprot/O46794" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">O46794</a>, <a href="https://www.uniprot.org/uniprot/O78049" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">O78049</a>, <a href="https://www.uniprot.org/uniprot/O78162" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">O78162</a>, <a href="https://www.uniprot.org/uniprot/P01913" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">P01913</a>, <a href="https://www.uniprot.org/uniprot/P79483" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">P79483</a>, <a href="https://www.uniprot.org/uniprot/P79663" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">P79663</a>, <a href="https://www.uniprot.org/uniprot/Q29721" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q29721</a>, <a href="https://www.uniprot.org/uniprot/Q29809" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q29809</a>, <a href="https://www.uniprot.org/uniprot/Q2PPD0" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q2PPD0</a>, <a href="https://www.uniprot.org/uniprot/Q30144" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q30144</a>, <a href="https://www.uniprot.org/uniprot/Q507L8" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q507L8</a>, <a href="https://www.uniprot.org/uniprot/Q5SP44" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q5SP44</a>, <a href="https://www.uniprot.org/uniprot/Q5STE0" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q5STE0</a>, <a href="https://www.uniprot.org/uniprot/Q6YJU6" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q6YJU6</a>, <a href="https://www.uniprot.org/uniprot/Q70M87" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q70M87</a>, <a href="https://www.uniprot.org/uniprot/Q7YQ62" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q7YQ62</a>, <a href="https://www.uniprot.org/uniprot/Q860I9" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q860I9</a>, <a href="https://www.uniprot.org/uniprot/Q8SP69" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q8SP69</a>, <a href="https://www.uniprot.org/uniprot/Q8WLT7" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q8WLT7</a>, <a href="https://www.uniprot.org/uniprot/Q8WLT8" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q8WLT8</a>, <a href="https://www.uniprot.org/uniprot/Q95359" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q95359</a>, <a href="https://www.uniprot.org/uniprot/Q95HM8" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q95HM8</a>, <a href="https://www.uniprot.org/uniprot/Q95IE5" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q95IE5</a>, <a href="https://www.uniprot.org/uniprot/Q96H16" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q96H16</a>, <a href="https://www.uniprot.org/uniprot/Q9BCP3" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q9BCP3</a>, <a href="https://www.uniprot.org/uniprot/Q9BD18" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q9BD18</a>, <a href="https://www.uniprot.org/uniprot/Q9MYA4" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q9MYA4</a>, <a href="https://www.uniprot.org/uniprot/Q9MYH3" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q9MYH3</a>, <a href="https://www.uniprot.org/uniprot/Q9MYH4" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q9MYH4</a>, <a href="https://www.uniprot.org/uniprot/Q9TP01" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q9TP01</a>, <a href="https://www.uniprot.org/uniprot/Q9TP02" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q9TP02</a>, <a href="https://www.uniprot.org/uniprot/Q9TPB5" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q9TPB5</a>, <a href="https://www.uniprot.org/uniprot/Q9TQ21" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q9TQ21</a>, <a href="https://www.uniprot.org/uniprot/Q9UIN3" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q9UIN3</a>, <a href="https://www.uniprot.org/uniprot/Q9UIN5" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">Q9UIN5</a></dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd><a href="https://www.uniprot.org/uniprot/A0A4D6G1L1" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">A0A4D6G1L1</a>, <a href="https://www.uniprot.org/uniprot/A0A4Y5R8W3" ref="itool=Gene_FullReport&PrId=5380&uid=3125&nlmid=&db=gene">A0A4Y5R8W3</a></dd>
|
||
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_072049.2">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=395773">pfam00969</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">42</span> → <span class="cddto">116</span></dt>
|
||
<dd class="clearfix"> MHC_II_beta; Class II histocompatibility antigen, beta domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=409591">cd21000</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">123</span> → <span class="cddto">218</span></dt>
|
||
<dd class="clearfix"> IgC1_MHC_II_beta_HLA-DR; Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain of histocompatibility antigen (HLA) DR; member of the C1-set of Ig superfamily (IgSF) domains</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
</div>
|
||
<h3 class="genomerefseqs gene_std_toggler" id="annotatedrefseq-title">
|
||
<a class="jig-ncbitoggler-open">RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08</a>
|
||
</h3>
|
||
<div class="genomerefseqs_slave">
|
||
<p class="desc"> The following sections contain reference sequences that belong to a
|
||
specific genome build. <a href="#" id="expl-genomes">Explain</a></p>
|
||
<p id="expl-genomes-desc" style="display:none">This section includes genomic Reference
|
||
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
|
||
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
|
||
assemblies. Model RNAs and proteins are also reported here.</p>
|
||
<h3 id="refseq-sequencedescription-p155916768">Reference GRCh38.p14 ALT_REF_LOCI_1</h3>
|
||
<h4 id="genomic-p155916768">Genomic </h4>
|
||
<ol>
|
||
<li>
|
||
<p>NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1</p>
|
||
<dl>
|
||
<dt>Range</dt>
|
||
<dd class="rs-range">
|
||
<span>3824508..3837642 complement</span>
|
||
</dd>
|
||
<dt>Download</dt>
|
||
<dd><a href="/nuccore/NT_167244.2?from=3824508&to=3837642&report=genbank&strand=true" ref="ordinalpos=1&ncbi_uid=3125&link_uid=NT_167244.2?from=3824508&to=3837642&report=genbank&strand=true">GenBank</a>, <a href="/nuccore/NT_167244.2?from=3824508&to=3837642&report=fasta&strand=true" ref="ordinalpos=1&ncbi_uid=3125&link_uid=NT_167244.2?from=3824508&to=3837642&report=fasta&strand=true">FASTA</a>, <a href="/nuccore/NT_167244.2?from=3822537&to=3839611&report=graph&content=5&strand=true" ref="ordinalpos=1&ncbi_uid=3125&link_uid=NT_167244.2?from=3822537&to=3839611&report=graph&content=5&strand=true">Sequence Viewer (Graphics)</a></dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
<h3 id="refseq-sequencedescription-p23689280">Reference GRCh38.p14 ALT_REF_LOCI_2</h3>
|
||
<h4 id="genomic-p23689280">Genomic </h4>
|
||
<ol>
|
||
<li>
|
||
<p>NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2</p>
|
||
<dl>
|
||
<dt>Range</dt>
|
||
<dd class="rs-range">
|
||
<span>3934018..3947156 complement</span>
|
||
</dd>
|
||
<dt>Download</dt>
|
||
<dd><a href="/nuccore/NT_113891.3?from=3934018&to=3947156&report=genbank&strand=true" ref="ordinalpos=1&ncbi_uid=3125&link_uid=NT_113891.3?from=3934018&to=3947156&report=genbank&strand=true">GenBank</a>, <a href="/nuccore/NT_113891.3?from=3934018&to=3947156&report=fasta&strand=true" ref="ordinalpos=1&ncbi_uid=3125&link_uid=NT_113891.3?from=3934018&to=3947156&report=fasta&strand=true">FASTA</a>, <a href="/nuccore/NT_113891.3?from=3932046&to=3949126&report=graph&content=5&strand=true" ref="ordinalpos=1&ncbi_uid=3125&link_uid=NT_113891.3?from=3932046&to=3949126&report=graph&content=5&strand=true">Sequence Viewer (Graphics)</a></dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
<h3 id="refseq-sequencedescription-p14535072">Reference GRCh38.p14 ALT_REF_LOCI_6</h3>
|
||
<h4 id="genomic-p14535072">Genomic </h4>
|
||
<ol>
|
||
<li>
|
||
<p>NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6</p>
|
||
<dl>
|
||
<dt>Range</dt>
|
||
<dd class="rs-range">
|
||
<span>3715352..3728489 complement</span>
|
||
</dd>
|
||
<dt>Download</dt>
|
||
<dd><a href="/nuccore/NT_167248.2?from=3715352&to=3728489&report=genbank&strand=true" ref="ordinalpos=1&ncbi_uid=3125&link_uid=NT_167248.2?from=3715352&to=3728489&report=genbank&strand=true">GenBank</a>, <a href="/nuccore/NT_167248.2?from=3715352&to=3728489&report=fasta&strand=true" ref="ordinalpos=1&ncbi_uid=3125&link_uid=NT_167248.2?from=3715352&to=3728489&report=fasta&strand=true">FASTA</a>, <a href="/nuccore/NT_167248.2?from=3713380&to=3730459&report=graph&content=5&strand=true" ref="ordinalpos=1&ncbi_uid=3125&link_uid=NT_167248.2?from=3713380&to=3730459&report=graph&content=5&strand=true">Sequence Viewer (Graphics)</a></dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
<h3 id="refseq-sequencedescription-p15983552">Alternate T2T-CHM13v2.0</h3>
|
||
<h4 id="genomic-p15983552">Genomic </h4>
|
||
<ol>
|
||
<li>
|
||
<p>NC_060930.1 Alternate T2T-CHM13v2.0</p>
|
||
<dl>
|
||
<dt>Range</dt>
|
||
<dd class="rs-range">
|
||
<span>32345227..32358367 complement</span>
|
||
</dd>
|
||
<dt>Download</dt>
|
||
<dd><a href="/nuccore/NC_060930.1?from=32345227&to=32358367&report=genbank&strand=true" ref="ordinalpos=1&ncbi_uid=3125&link_uid=NC_060930.1?from=32345227&to=32358367&report=genbank&strand=true">GenBank</a>, <a href="/nuccore/NC_060930.1?from=32345227&to=32358367&report=fasta&strand=true" ref="ordinalpos=1&ncbi_uid=3125&link_uid=NC_060930.1?from=32345227&to=32358367&report=fasta&strand=true">FASTA</a>, <a href="/nuccore/NC_060930.1?from=32343255&to=32360337&report=graph&content=5&strand=true" ref="ordinalpos=1&ncbi_uid=3125&link_uid=NC_060930.1?from=32343255&to=32360337&report=graph&content=5&strand=true">Sequence Viewer (Graphics)</a></dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-related-sequences">
|
||
<section class="rprt-section-header" id="related-sequences">
|
||
<h2 id="header-related-sequences">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-related-sequences .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Related sequences</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Related_Sequences" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div>
|
||
<table id="proteinTblId" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/3125/data/related-sequences/',webserviceParams: 'p$l=Ajax', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
|
||
<thead>
|
||
<tr>
|
||
<th colspan="2" id="rs-nucleo">Nucleotide</th>
|
||
<th rowspan="2" id="rs-protein">Protein</th>
|
||
</tr>
|
||
<tr>
|
||
<th id="rs-heading">Heading</th>
|
||
<th id="rs-heading-acc">Accession and Version</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody></tbody>
|
||
</table>
|
||
<table id="proteinTblId" class="jig-ncbigrid" data-jigconfig="isPageable:true, pageSize:25">
|
||
<thead>
|
||
<tr>
|
||
<th class="proteinTblTh" rowspan="2" id="rs-prot-acc">Protein Accession</th>
|
||
<th class="proteinTblTh" colspan="2" id="rs-link">Links</th>
|
||
</tr>
|
||
<tr>
|
||
<th id="rs-genepept">GenPept Link</th>
|
||
<th id="rs-uniprot">UniProtKB Link</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="rs-prot-acc">P79483.1</td>
|
||
<td headers="rs-link rs-genepept">
|
||
<a href="/protein/34395491" ref="ordinalpos=1&ncbi_uid=3125&link_uid=34395491">GenPept</a>
|
||
</td>
|
||
<td>
|
||
<a href="https://www.uniprot.org/uniprot/P79483">UniProtKB/Swiss-Prot:P79483</a>
|
||
</td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-additional-links">
|
||
|
||
<section class="rprt-section-header" id="additional-links"><h2 id="header-additional-links"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-additional-links .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Additional links</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Additional_Links" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
|
||
|
||
<div class="rprt-section-body" style="">
|
||
|
||
|
||
<h3 class="withnote" id="genelinkout">
|
||
<a class="jig-ncbitoggler">Gene LinkOut</a>
|
||
</h3><div>
|
||
<p>The following <a href="https://www.ncbi.nlm.nih.gov/projects/linkout/index.html">LinkOut</a> resources are supplied by external providers. These providers are responsible for maintaining the links. </p>
|
||
<div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Chemical Information</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>Interologous Interaction Database</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://ophid.utoronto.ca/redirect/ncbi/human?proteins=3125" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=7911">
|
||
<span>Interologous Interaction Database</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>MilliporeSigma</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.sigmaaldrich.com/catalog/genes/HLA-DRB3?lang=en&region=US" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=9978">
|
||
<span>HLA-DRB3 products</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Molecular Biology Databases</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>BioGPS</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://biogps.org/gene/3125/" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=5059">
|
||
<span>BioGPS</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>BioGRID Open Repository of CRISPR Screens (ORCS)</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://orcs.thebiogrid.org/Gene/3125" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=10164">
|
||
<span>BioGRID CRISPR Screen Phenotypes (0 hits/14 screens)</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>Domain Mapping of Disease Mutations</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://bioinf.umbc.edu/DMDM/gene_prot_page.php?id=3125" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=7642">
|
||
<span>HLA-DRB3</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>GlyGen glycoinformatics resource</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://glygen.org/protein/P79483" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=10227">
|
||
<span>GlyGen glycoinformatics resource</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span><span class="regis-rsc"></span>Human Gene Mutation Database</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://www.hgmd.cf.ac.uk/ac/gene.php?gene=HLA-DPB1" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=3100">
|
||
<span>Human Gene Mutation Database</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li>Ingenuity Pathways Analysis</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://partnersolution.ingenuity.com/?cid=97ae3f91eab87a&p1=Entrez&p2=GV&s=&ipaUri=%2Fpa%2Fapi%2Fv2%2Fgeneview%3Fapplicationname%3DEntrez%26geneId%3D3125%26geneidtype%3Dentrezgene" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=5628">
|
||
<span>Ingenuity Pathways Analysis</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>InnateDB</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://www.innatedb.com/getGeneCard.do?id=303986" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=7894">
|
||
<span>InnateDB</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>Kyoto Encyclopedia of Genes and Genomes</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://www.genome.jp/dbget-bin/www_bget?hsa:3125" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=5174">
|
||
<span>Kyoto Encyclopedia of Genes and Genomes</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>Pharmacogenomics Knowledge Base</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.pharmgkb.org/gene/PA35074" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=4067">
|
||
<span>Annotated Pharmacogenomic Information for HLA-DRB3 [PharmGKB]</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>PhosphoSitePlus</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.phosphosite.org/entrezGeneIdAction.action?id=3125" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=7987">
|
||
<span>PhosphoSitePlus® - comprehensive post-translational modification resource</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>The Gene Wiki</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://en.wikipedia.org/wiki/HLA-DRB3_(gene)" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=6933">
|
||
<span>The Gene Wiki</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>The Weizmann Institute of Science GeneCards and MalaCards databases</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=HLA-DRB3" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=8598">
|
||
<span>GeneCard for HLA-DRB3</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Research Materials</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="order-rsc"></span>Addgene Non-profit plasmid repository</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://addgene.org//browse/gene/3125" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=5304">
|
||
<span>Get Plasmids - Addgene</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>Bio-Techne</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.bio-techne.com/t/hla-drb3/antibodies?utm_source=linkout&utm_medium=referral&utm_campaign=product&utm_term=antibodies" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=8242">
|
||
<span>HLA DRB3 Antibodies</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.bio-techne.com/t/hla-drb3/proteins-enzymes?utm_source=linkout&utm_medium=referral&utm_campaign=product&utm_term=proteins" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=8242">
|
||
<span>HLA DRB3 Proteins</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.bio-techne.com/t/hla-drb3/lysates?utm_source=linkout&utm_medium=referral&utm_campaign=product&utm_term=lysates" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=8242">
|
||
<span>HLA DRB3 Lysates</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>Creative Biogene</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.creative-biogene.com/genesearch/HLA-DRB3.html" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=10094">
|
||
<span>major histocompatibility complex, class II, DR beta 3</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li>ExactAntigen/Labome</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.labome.com/review/gene/human/HLA-DRB3-antibody.html" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=5753">
|
||
<span>reagent review</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.labome.com/gene/human/HLA-DRB3-antibody.html" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=5753">
|
||
<span>reagents</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>GenScript latest version of gene cDNA ORF Clone</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://www.genscript.com/gene/3125" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=8012">
|
||
<span>GenScript latest version of gene cDNA ORF Clone</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>GeneCopoeia Inc.</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=26&field=5&key=3125" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=7255">
|
||
<span>Order TALEN/CRISPR clones</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?tax_id=9606&field=5&prt=16&key=3125" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=7255">
|
||
<span>Order miRNA target clones</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=1&field=5&key=3125" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=7255">
|
||
<span>Order full-length ORF clone</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>GeneTex Inc</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.genetex.com/Product/Search?geneid=3125&type=01&page=1" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=8117">
|
||
<span>Find Quality Antibodies</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>Kazusa DNA Research Institute</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://www.kazusa.or.jp/kop/dsearch/symsearch.cgi?keyword=HLA-DPB1;" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=3267">
|
||
<span>Kazusa DNA Research Institute</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="http://www.kazusa.or.jp/kop/dsearch/symsearch.cgi?keyword=HLA-DRB3;" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=3267">
|
||
<span>Kazusa DNA Research Institute</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>OriGene</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.origene.com/search?q=HLA-DRB3" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=7994">
|
||
<span>Order HLA-DRB3 cDNA clone/Protein/Antibody/RNAi</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.origene.com/search?q=HLA-DPB1" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=7994">
|
||
<span>Order HLA-DPB1 cDNA clone/Protein/Antibody/RNAi</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open">
|
||
<span>Miscellaneous</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>Reactome</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://reactome.org/PathwayBrowser/#/R-HSA-168256" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=4914">
|
||
<span>Reactome Event:Immune System</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://reactome.org/content/query?q=UniProt:P79483" ref="itool=Gene_FullReport&uid=3125&nlmid=&db=gene&log$=linkoutlink&PrId=4914">
|
||
<span>Reactome Entity:P79483</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="urls-in-genombrowser" style="display:none">
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div><input type="hidden" class="section_status_input" name="status_checked" id="status_checked" value="" /><input type="hidden" class="section_status_input" name="status_open" id="status_open" value="summary,region,context,bibliography,phenotypes,variation,hiv,interactions,pathways,geneInfo,proteinInfo,refSeq,related,links" /><input type="hidden" class="section_status_input" name="status_exist" id="status_exist" value="summary,context,region,bibliography,phenotypes,variation,hiv,,interactions,geneInfo,proteinInfo,refSeq,related,links" /><input type="hidden" class="section_status_input" name="status_closed" id="status_closed" value="" /><meta name="status_checked" content="" class="meta_section_status" /><meta name="status_open" content="summary,region,context,bibliography,phenotypes,variation,hiv,interactions,pathways,geneInfo,proteinInfo,refSeq,related,links" class="meta_section_status" /><meta name="status_exist" content="summary,context,region,bibliography,phenotypes,variation,hiv,,interactions,geneInfo,proteinInfo,refSeq,related,links" class="meta_section_status" /><meta name="status_closed" content="" class="meta_section_status" /><script type="text/javascript">
|
||
|
||
var section_status_meta = {
|
||
'status_checked': '',
|
||
'status_open': 'summary,region,context,bibliography,phenotypes,variation,hiv,interactions,pathways,geneInfo,proteinInfo,refSeq,related,links',
|
||
'status_exist': 'summary,context,region,bibliography,phenotypes,variation,hiv,,interactions,geneInfo,proteinInfo,refSeq,related,links',
|
||
'status_closed': ''
|
||
};
|
||
|
||
|
||
/*
|
||
for (var o in section_status_meta) {
|
||
var meta=document.createElement('meta');
|
||
meta.name = o;
|
||
meta.content = section_status_meta[o];
|
||
var attr = document.createAttribute('data-ignore-limit');
|
||
attr.value = 'true';
|
||
meta.setAttributeNode(attr);
|
||
document.getElementsByTagName('head')[0].appendChild(meta);
|
||
}
|
||
*/
|
||
|
||
|
||
var __ncbi_sg_pingCallbacks_render_gene = function (data, evtObj, type) {
|
||
// data looks like {jsevent: "click", "link_id": "foo", ...}
|
||
// evtObj is the JS event object
|
||
// type is either "stat" (for applog) or "ga"
|
||
var extraData = {};
|
||
if (type == "stat") {
|
||
for (var o in section_status_meta) {
|
||
extraData[o] = section_status_meta[o];
|
||
}
|
||
|
||
return extraData;
|
||
|
||
}
|
||
}
|
||
|
||
|
||
</script></div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last" id="sidebar_tabular">
|
||
<!-- sidebar close/hide button-->
|
||
<div class="ui-helper-clearfix">
|
||
<a href="#" id="sidecontent_2_pullout" style="float:right;" class="sidecontentpullout_local collapse_button"><span>Hide sidebar >></span></a>
|
||
</div>
|
||
<!-- end sidebar close/hide button-->
|
||
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div id="gene-sidebar">
|
||
<div>
|
||
<div class="portlet brieflink dis-table-of-contents">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Table of contents</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_TableOfContents" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li class="">
|
||
<a href="#summary">Summary</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#genomic-context">Genomic context</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#genomic-regions-transcripts-products">Genomic regions, transcripts, and products</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#bibliography">Bibliography</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#phenotypes">Phenotypes</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#variation">Variation</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#HIV-1-interactions">HIV-1 interactions</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#pathways">Pathways from PubChem</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#interactions">Interactions</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#general-gene-info">General gene information</a>
|
||
<div class="subsection-links"><a href="#gene-markers">Markers</a>, <a href="#CloneNames">Clone Names</a>, <a href="#gene-ontology">Gene Ontology</a></div>
|
||
</li>
|
||
<li class="">
|
||
<a href="#general-protein-info">General protein information</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#reference-sequences">NCBI Reference Sequences (RefSeq)</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#related-sequences">Related sequences</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#additional-links">Additional links</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-genomesbrowser brieflink dis-genomesbrowser">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Genome Browsers</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GenomeBrowsers.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GenomeBrowsers" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GenomeBrowsers.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="#">Loading...</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet dis-related-info brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content DiscoveryDbLinks">
|
||
<ul>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clone/order/gene/3125" ref="log$=recordlinks">Order cDNA clone</a>
|
||
<div class="brieflinkpop offscreen_noflow">Order cDNA clone</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/structure?LinkName=gene_structure&from_uid=3125" ref="log$=recordlinks">3D structures</a>
|
||
<div class="brieflinkpop offscreen_noflow">3D structure of a gene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_alltarget_list&from_uid=3125" ref="log$=recordlinks">BioAssay by Target (List)</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioAssays related to the gene by protein target or RNAi target</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="//pubchem.ncbi.nlm.nih.gov/assay/bioactivity.html?geneid=3125" ref="log$=recordlinks">BioAssay by Target (Summary)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Summarized PubChem Data on the gene, showing the active data by default</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_target&from_uid=3125" ref="log$=recordlinks">BioAssay, by Gene target</a>
|
||
<div class="brieflinkpop offscreen_noflow">PubChem BioAssays done on the Gene target</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai_active&from_uid=3125" ref="log$=recordlinks">BioAssays, RNAi Target, Active</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent, which is identified as a hit in a RNAi screening and flagged as "active" in the corresponding BioAssay record</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai&from_uid=3125" ref="log$=recordlinks">BioAssays, RNAi Target, Tested</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/bioproject?LinkName=gene_bioproject&from_uid=3125" ref="log$=recordlinks">BioProjects</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioProjects related to a gene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/biosystems?LinkName=gene_biosystems&from_uid=3125" ref="log$=recordlinks">BioSystems</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioSystems</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/cdd?LinkName=gene_cdd&from_uid=3125" ref="log$=recordlinks">Conserved Domains</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related CDD</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/dbvar?LinkName=gene_dbvar&from_uid=3125" ref="log$=recordlinks">dbVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link from Gene to dbVar</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc&from_uid=3125" ref="log$=recordlinks">Full text in PMC</a>
|
||
<div class="brieflinkpop offscreen_noflow">PMC links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc_nucleotide&from_uid=3125" ref="log$=recordlinks">Full text in PMC_nucleotide</a>
|
||
<div class="brieflinkpop offscreen_noflow">Full text in PubMedCentral identified from shared sequence links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/sparcle?LinkName=gene_sparcle&from_uid=3125" ref="log$=recordlinks">Functional Class</a>
|
||
<div class="brieflinkpop offscreen_noflow">Functional class of the sequence domain architecture</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gene?LinkName=gene_gene_neighbors&from_uid=3125" ref="log$=recordlinks">Gene neighbors</a>
|
||
<div class="brieflinkpop offscreen_noflow">Overlapping genes and two nearest non-overlapping genes on either side</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/genome?LinkName=gene_genome&from_uid=3125" ref="log$=recordlinks">Genome</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related Genome</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/geoprofiles?LinkName=gene_geoprofiles&from_uid=3125" ref="log$=recordlinks">GEO Profiles</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related GEO</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests/?term=3125[geneid]" ref="log$=recordlinks">GTR</a>
|
||
<div class="brieflinkpop offscreen_noflow">Tests for this gene in the NIH Genetic Testing Registry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore&from_uid=3125" ref="log$=recordlinks">Nucleotide</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related Nucleotide entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/omim?LinkName=gene_omim&from_uid=3125" ref="log$=recordlinks">OMIM</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related OMIM entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/probe?LinkName=gene_probe&from_uid=3125" ref="log$=recordlinks">Probe</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related Probe entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein&from_uid=3125" ref="log$=recordlinks">Protein</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related protein entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pccompound?LinkName=gene_pccompound&from_uid=3125" ref="log$=recordlinks">PubChem Compound</a>
|
||
<div class="brieflinkpop offscreen_noflow">PubChem Compounds</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcsubstance?LinkName=gene_pcsubstance&from_uid=3125" ref="log$=recordlinks">PubChem Substance</a>
|
||
<div class="brieflinkpop offscreen_noflow">PubChem Substances</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed&from_uid=3125" ref="log$=recordlinks">PubMed</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related PubMed entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_rif&from_uid=3125" ref="log$=recordlinks">PubMed (GeneRIF)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related PubMed article from GeneRIFs</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_citedinomim&from_uid=3125" ref="log$=recordlinks">PubMed (OMIM)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Gene links to PubMed derived from omim_pubmed_cited links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_pmc_nucleotide&from_uid=3125" ref="log$=recordlinks">PubMed(nucleotide/PMC)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Citations in PubMed identified from shared sequence and PMC links.</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein_refseq&from_uid=3125" ref="log$=recordlinks">RefSeq Proteins</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to Protein RefSeqs</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore_refseqrna&from_uid=3125" ref="log$=recordlinks">RefSeq RNAs</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to Nucleotide RefSeq RNAs</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/snp?LinkName=gene_snp&from_uid=3125" ref="log$=recordlinks">SNP</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related SNP records</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/taxonomy?LinkName=gene_taxonomy&from_uid=3125" ref="log$=recordlinks">Taxonomy</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related taxonomy entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/variation/view/?q=3125[geneid]" ref="log$=recordlinks">Variation Viewer</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related Variants</div>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet dis-links-to-other-res brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Links to other resources</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_LinksTwo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4951">HGNC</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.alliancegenome.org/gene/HGNC:4951">AllianceGenome</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=geneid&org=9606&l=3125">AceView</a>
|
||
</li>
|
||
<li>
|
||
<a href="http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_022555">UCSC</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/gv/mhc/align.fcgi?cmd=aligndisplay&lid=3125">dbMHC</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://genecollections.nci.nih.gov/MGC/?ORG=Hs&LIST=BC001023,BC008987,BC106057">MGC</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://phgkb.cdc.gov/PHGKB/huGEPedia.action?firstQuery=HLA-DRB3&geneID=3125&typeOption=gene&which=2&pubOrderType=pubD&typeSubmit=GO&check=y">HuGE Navigator</a>
|
||
</li>
|
||
<li>
|
||
<a href="http://www.genome.jp/dbget-bin/www_bget?hsa:3125">KEGG</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://reactome.org/content/query?q=UniProt:P79483">Reactome</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-general-info">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>General information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GeneralInfo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="/pmc/?term=PMC4383897+OR+PMC3013746+OR+PMC1761442+OR+PMC539985">About Gene</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK3840">FAQ</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://ftp.ncbi.nlm.nih.gov/gene/">FTP site</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK3841/">Help</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK3842/">My NCBI help</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK21085/">NCBI Handbook</a>
|
||
</li>
|
||
<li>
|
||
<a href="/gene/statistics/">Statistics</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-related-sites">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related sites</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_RelatedSites" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/BLAST">BLAST</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/genome">Genome</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/bioproject">BioProject</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/genome/gdv/">Genome Data Viewer</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/geo">GEO</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/omim">OMIM</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/probe">Probe</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/RefSeq">RefSeq</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-feedback">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Feedback</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_Feedback" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="https://support.ncbi.nlm.nih.gov/ics/support/ticketnewwizard.asp?style=classic&deptID=28049">Contact Help Desk</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/RefSeq/update.cgi?geneid=3125&symbol=HLA-DRB3">Submit Correction</a>
|
||
</li>
|
||
<li>
|
||
<a href="/gene/submit-generif?geneId=3125&sym=HLA-DRB3&name=major histocompatibility complex, class II, DR beta 3&org=Homo sapiens">Submit GeneRIF</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-subscription">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Subscription</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Subscription.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_Subscription" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Subscription.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/mailman/listinfo/refseq-announce">RefSeq</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<!-- <component id="Gene_RVFullReport.Gene_RightColMenuLinks"/>-->
|
||
<div class="portlet">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Recent activity</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="recent_activity" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<div id="HTDisplay" class="">
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.Cmd" sid="1" type="hidden" />
|
||
<div class="action">
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.ClearHistory" sid="1" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.ClearHistory" cmd="ClearHT" href="?cmd=ClearHT&" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.ClearHistory">
|
||
Clear
|
||
</a>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" sid="1" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOn" cmd="HTOff" href="?cmd=HTOff&" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle">
|
||
Turn Off
|
||
</a>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" sid="2" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOff" cmd="HTOn" href="?cmd=HTOn&" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle">
|
||
Turn On
|
||
</a>
|
||
</div>
|
||
<ul id="activity">
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67c9de57f4a390645e2de1dc">HLA-DRB3 major histocompatibility complex, class II, DR beta 3 [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">HLA-DRB3 major histocompatibility complex, class II, DR beta 3 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:3125</div></div>
|
||
<div class="tertiary">Gene</div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67c9de55a68b6b5afc65e161">major histocompatibility complex, class II, DR beta 3 precursor [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">major histocompatibility complex, class II, DR beta 3 precursor [Homo sapiens]<div class="brieflinkpopdesc">gi|17986005|ref|NP_072049.2|</div></div>
|
||
<div class="tertiary">Protein</div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67c9de51a68b6b5afc65d214">HLA-DRB1 major histocompatibility complex, class II, DR beta 1 [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">HLA-DRB1 major histocompatibility complex, class II, DR beta 1 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:3123</div></div>
|
||
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<div class="ralinkpop offscreen_noflow">major histocompatibility complex, class II, DR beta 1 precursor [Homo sapiens]<div class="brieflinkpopdesc">gi|155030211|ref|NP_002115.2|</div></div>
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