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<div class="search"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="pubmed">PubMed</option><option value="clinvar">ClinVar</option><option value="medgen">MedGen</option><option value="books" class="last">Books</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly" data-ac_dict="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene" selected="selected" data-ac_dict="gene">Gene</option><option value="genome" data-ac_dict="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen">MedGen</option><option value="mesh">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore" data-ac_dict="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein" data-ac_dict="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search Gene. Use up and down arrows to choose an item from the autocomplete." value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="dictionary:'gene',disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'yes',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div><ul class="searchlinks inline_list"><set></set><li><a href="/gene/advanced">Advanced</a></li><li class="help"><a id="help" class="jig-ncbihelpwindow" target="ncbihelp" name="help" href="/books/NBK3841/">Help</a></li></ul></div>
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<div class="facet_cont" data-db="gene" data-default_grps="fg_gene-sources,fg_categories,fg_sequence-content,fg_status" data-sd="db:'gene',op:'select',term:'',qk:'5483',linkname:'',idsfromresult:'11140',extra:''"><ul class="facet" data-filter_id="gene-sources" id="_gene-sources"><li class="filter_grp "><div class="clearfix"><h3>Gene sources</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="genomic">Genomic</a></li></ul></li></ul><ul class="facet" data-filter_id="categories" id="_categories"><li class="filter_grp "><div class="clearfix"><h3>Categories</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="annotated-genes">Annotated genes</a></li><li class="fil_val"><a href="#" data-value_id="gene-type-protein-coding">Protein-coding</a></li></ul></li></ul><ul class="facet" data-filter_id="sequence-content" id="_sequence-content"><li class="filter_grp "><div class="clearfix"><h3>Sequence content</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="seq-ccds">CCDS</a></li><li class="fil_val"><a href="#" data-value_id="seq-ensembl">Ensembl</a></li><li class="fil_val"><a href="#" data-value_id="refseq">RefSeq</a></li></ul></li></ul><ul class="facet" data-filter_id="status" id="_status"><li class="filter_grp "><div class="clearfix"><h3>Status</h3><a href="#" data-value_id="" class="clear clear_show">Clear</a></div><ul><li class="fil_val selected"><a href="#" data-value_id="current-only">Current</a><span class="fcount">(1)</span></li></ul></li></ul><div id="chr-location-facet-wrapper" data-bid="MCID_67c9f0e7d74f67691045099e" data-hid="MCID_67c90f2d64f30b25346ccae2" data-qky="5483" class="disabled" style="display:none"><ul class="facet" data-filter_id="chromosomal-region" id="_chromosomal-region" data-of="yes"><li class="filter_grp of_grp"><div class="clearfix"><h3>Chromosome locations</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><a id="facet_ofchromosomal-region" href="#facet_of_divchromosomal-region" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'middle left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '375px'" data-value_id="fetch_more">more...</a><div id="facet_of_divchromosomal-region" style="display:none;" class="of_popup"><h4>Chromosome locations</h4><label for="organism-filter" style="width:100%;margin-bottom:.2em;" class="">Select an organism by typing or scrolling</label><input type="text" placeholder="Enter text to narrow down the list" id="organism-filter" style="width:98%;" autocomplete="off" /><br /><div id="chr-region-tax-list"><select id="of_chromosomal-region" size="9" class="chr-region-tax-list" style="width:100%;"></select></div><div id="chr-location-info-ctrl" data-disabled="disabled"><div class="chr-field"><label for="chr-name">Chromosome</label><br /><select id="chr-name" class="chr-field" disabled="disabled"></select></div><div class="chr-field"><label for="chr-from">From</label><br /><input type="text" name="chr-from" id="chr-from" disabled="disabled" class="chr-field" /></div><div class="chr-field"><label for="chr-to">To</label><br /><input type="text" name="chr-to" id="chr-to" disabled="disabled" class="chr-field" /></div></div><div class="actions clearfix"><button class="jig-ncbibutton of_add apply-chr" data-jigconfig="'color': 'ui-ncbibutton-blue'">Apply</button></div></div></ul></li></ul></div><ul class="facet facet_reset"><li><a href="#" data-value_id="reset">Clear all</a></li></ul><ul class="facet_tools"><li><a id="more_filter_groups_link" href="#more_filter_groups" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'top left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '180px'">
Show additional filters</a></li><div id="more_filter_groups" style="display:none;" class="facets_dialog"><button class="ui-ncbipopper-close-button ui-ncbipopper-close-button-generated ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-blue" generated="true" role="button" aria-disabled="false"><span class="ui-button-text">x</span></button><h4>Additional filters</h4><ul class="filter_groups_more facet"><li><input type="checkbox" id="fg_gene-sources" /><label for="fg_gene-sources">Gene sources</label></li><li><input type="checkbox" id="fg_categories" /><label for="fg_categories">Categories</label></li><li><input type="checkbox" id="fg_sequence-content" /><label for="fg_sequence-content">Sequence content</label></li><li><input type="checkbox" id="fg_status" /><label for="fg_status">Status</label></li><li><input type="checkbox" id="fg_chromosomal-region" /><label for="fg_chromosomal-region">Chromosome locations</label></li><li><input id="fg_field_search" type="checkbox" /><label for="fg_field_search">Search fields</label></li></ul><div class="actions clearfix"><button class="filter_groups_more_apply jig-ncbibutton primary-action" id="filter_groups_apply" data-jigconfig="'color': 'ui-ncbibutton-blue'">Show</button></div></div></ul><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetsUrlFrag" sid="1" type="hidden" value="filters=current-only" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetSubmitted" sid="1" type="hidden" value="false" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.BMFacets" sid="1" type="hidden" value="" /></div>
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<h1 class="title" id="gene-name"><span class="gn" style="padding-right:.5em;">CDC37</span> cell division cycle 37, HSP90 cochaperone [ <em class="tax">Homo sapiens</em> (human)
]
</h1>
<span class="geneid">Gene ID: 11140, updated on
4-Mar-2025</span>
</div>
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<div class="rprt-section gene-summary">
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<dl id="summaryDl">
<dt class="noline"> Official
Symbol</dt>
<dd class="noline">CDC37<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
<dt> Official
Full Name</dt>
<dd>cell division cycle 37, HSP90 cochaperone<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
<dt>Primary source</dt>
<dd>
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1735" data-gblink-text="Ensembl">HGNC:HGNC:1735</a>
</dd>
<dt>See related</dt>
<dd>
<a href="http://www.ensembl.org/id/ENSG00000105401" data-gblink-text="Ensembl" class="genome-browser-link" data-genome-browser-link-sort="5" data-gb-url="http://www.ensembl.org/loc/ENSG00000105401">Ensembl:ENSG00000105401</a>
<a href="https://www.ncbi.nlm.nih.gov/omim/605065" data-gblink-text="Ensembl" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=605065">MIM:605065;</a>
<a href="https://www.alliancegenome.org/gene/HGNC:1735" data-gblink-text="Ensembl" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=HGNC:1735">AllianceGenome:HGNC:1735</a>
</dd>
<dt>Gene type</dt>
<dd>protein coding</dd>
<dt>RefSeq status</dt>
<dd>REVIEWED</dd>
<dt>Organism</dt>
<dd class="tax">
<a href="/Taxonomy/Browser/wwwtax.cgi?id=9606" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=9606">Homo sapiens</a>
</dd>
<dt>Lineage</dt>
<dd class="tax">Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo</dd>
<dt>Also known as</dt>
<dd>P50CDC37</dd>
<dt>Summary</dt>
<dd>The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]</dd>
<dt>Expression</dt>
<dd>Ubiquitous expression in fat (RPKM 70.6), spleen (RPKM 61.9) and 25 other tissues <a href="#gene-expression">See more</a></dd>
<dt>Orthologs</dt>
<dd class="ortholog-links">
<a href="https://www.ncbi.nlm.nih.gov/gene/12539">mouse</a>
<a href="/gene/11140/ortholog/">all</a>
</dd>
<dt style="padding-top:.5em;">
<span class="new-icon">NEW</span>
</dt>
<dd style="padding-top:.5em;">
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/11140/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="gene_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Gene table</a></strong>
<br />
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/11140/products/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="transcript_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Transcript table</a></strong>
</dd>
</dl>
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<div class="rprt-section gene-genomic-context">
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<div class="gc_cont">
<div class="gt_cont_contents">
<div style="float:right"><span>See CDC37 in </span><a href="/genome/gdv/?context=gene&amp;acc=11140" class="link-to-gdv genome-browser-link" data-genome-browser-link-sort="1" data-acc="GCF_000001405.40">Genome Data Viewer</a> </div>
<dl class="dl-chr-info" style="float:left;margin-top:0;">
<dt>Location: </dt>
<dd>
<span style="display:inline-block;">19p13.2</span>
</dd>
</dl>
</div>
<dl class="dl-chr-info exon-count">
<dt>Exon count: </dt>
<dd>8</dd>
</dl>
<div class="ui-ncbigrid-outer-div" id="genomic-context-tbl-location">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="">
<thead>
<tr>
<th style="max-width:15%">Annotation release</th>
<th style="max-width:10%">Status</th>
<th>Assembly</th>
<th>
<span title="Chromosome">Chr</span>
</th>
<th>Location</th>
</tr>
</thead>
<tbody>
<tr>
<td>RS_2024_08</td>
<td>current</td>
<td>GRCh38.p14 (<a href="/assembly/GCF_000001405.40/" ref="ncbi_uid=11140&amp;link_uid=GCF_000001405.40">GCF_000001405.40</a>)</td>
<td>19</td>
<td>NC_000019.10 (10391133..10403542, complement) </td>
</tr>
<tr>
<td>RS_2024_08</td>
<td>current</td>
<td>T2T-CHM13v2.0 (<a href="/assembly/GCF_009914755.1/" ref="ncbi_uid=11140&amp;link_uid=GCF_009914755.1">GCF_009914755.1</a>)</td>
<td>19</td>
<td>NC_060943.1 (10517575..10529998, complement) </td>
</tr>
<tr>
<td>RS_2024_09</td>
<td>previous assembly</td>
<td>GRCh37.p13 (<a href="/assembly/GCF_000001405.25/" ref="ncbi_uid=11140&amp;link_uid=GCF_000001405.25">GCF_000001405.25</a>)</td>
<td>19</td>
<td>NC_000019.9 (10501809..10514218, complement) </td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<p class="withnote margin_t2em"><strong>Chromosome 19 - NC_000019.10</strong><img usemap="#nbrMap11140_568815579" border="0" alt="Genomic Context describing neighboring genes" src="/gutils/geneneighb.fcgi?geneid=11140&amp;nuc_gi=568815579&amp;n0=LOC127890418&amp;n1=ICAM3&amp;n2=LOC127890419&amp;n3=LOC127890420&amp;n4=LOC130063487&amp;n5=LOC130063488&amp;n6=LOC127890421&amp;n7=LOC127890422&amp;n8=TYK2&amp;n9=LOC127890423&amp;n10=LOC127890424&amp;n11=LOC127890425&amp;n12=LOC130063489&amp;n13=LOC130063490&amp;n14=LOC127890426&amp;n15=CDC37&amp;n16=LOC130063491&amp;n17=MIR1181&amp;n18=LOC130063492&amp;n19=LOC130063493&amp;n20=LOC130063494&amp;n21=LOC130063495&amp;n22=PDE4A&amp;n23=LOC130063496&amp;n24=LOC127890427&amp;n25=LOC127890428&amp;n26=LOC127890429&amp;n27=LOC130063497&amp;n28=LOC130063498&amp;n29=LOC130063499&amp;n30=LOC130063500&amp;n31=LOC130063501&amp;n32=LOC130063502&amp;n33=LOC127890430&amp;n34=LOC127890431&amp;n35=LOC127890432&amp;n36=LOC130063503&amp;n37=LOC130063504&amp;n38=LOC130063505&amp;n39=LOC130063506&amp;n40=LOC127890433&amp;n41=LOC130063507&amp;n42=KEAP1&amp;n43=LOC127890434&amp;n44=LOC125371477&amp;n45=LOC130063508&amp;n46=LOC127890435&amp;n47=LOC130063509" /><map name="nbrMap11140_568815579" id="nbrMap11140_568815579">
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10443599-10444515')" onMouseOut="hidetip()" coords="2,23,72,31" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10443599-10444515" href="/gene/127890418" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr19:10445230-10445848')" onMouseOut="hidetip()" coords="5,35,75,43" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10445230-10445848" href="/gene/127890419" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr19:10448906-10449654')" onMouseOut="hidetip()" coords="13,47,83,55" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10448906-10449654" href="/gene/127890420" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 13959')" onMouseOut="hidetip()" coords="15,59,85,67" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13959" href="/gene/130063487" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 13960')" onMouseOut="hidetip()" coords="16,71,86,79" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13960" href="/gene/130063488" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10450403-10451150')" onMouseOut="hidetip()" coords="16,83,86,91" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10450403-10451150" href="/gene/127890421" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10451151-10451898')" onMouseOut="hidetip()" coords="18,95,88,103" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10451151-10451898" href="/gene/127890422" />
<area shape="rect" onMouseOver="showtip(this,event,'intercellular adhesion molecule 3')" onMouseOut="hidetip()" coords="39,107,78,115" alt="Neighboring gene intercellular adhesion molecule 3" href="/gene/3385" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10463923-10464686')" onMouseOut="hidetip()" coords="45,119,115,127" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10463923-10464686" href="/gene/127890423" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr19:10474734-10475234')" onMouseOut="hidetip()" coords="68,131,138,139" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10474734-10475234" href="/gene/127890424" />
<area shape="rect" onMouseOver="showtip(this,event,'tyrosine kinase 2')" onMouseOut="hidetip()" coords="79,23,164,31" alt="Neighboring gene tyrosine kinase 2" href="/gene/7297" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac hESC enhancer GRCh37_chr19:10491214-10491877')" onMouseOut="hidetip()" coords="102,35,172,43" alt="Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10491214-10491877" href="/gene/127890425" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 13962')" onMouseOut="hidetip()" coords="114,47,184,55" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13962" href="/gene/130063489" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 13963')" onMouseOut="hidetip()" coords="115,59,185,67" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13963" href="/gene/130063490" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr19:10499431-10499931')" onMouseOut="hidetip()" coords="120,71,190,79" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10499431-10499931" href="/gene/127890426" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 10066')" onMouseOut="hidetip()" coords="150,83,220,91" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10066" href="/gene/130063491" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 13965')" onMouseOut="hidetip()" coords="151,95,221,103" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13965" href="/gene/130063492" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 10067')" onMouseOut="hidetip()" coords="154,107,224,115" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10067" href="/gene/130063493" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 13966')" onMouseOut="hidetip()" coords="162,131,232,139" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13966" href="/gene/130063494" />
<area shape="rect" onMouseOver="showtip(this,event,'microRNA 1181')" onMouseOut="hidetip()" coords="176,23,221,31" alt="Neighboring gene microRNA 1181" href="/gene/100302213" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 10068')" onMouseOut="hidetip()" coords="178,35,248,43" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10068" href="/gene/130063495" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 13967')" onMouseOut="hidetip()" coords="179,143,249,151" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13967" href="/gene/130063496" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10527911-10528462')" onMouseOut="hidetip()" coords="180,155,250,163" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10527911-10528462" href="/gene/127890427" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10528463-10529013')" onMouseOut="hidetip()" coords="181,167,251,175" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10528463-10529013" href="/gene/127890428" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr19:10530007-10530886')" onMouseOut="hidetip()" coords="184,179,254,187" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10530007-10530886" href="/gene/127890429" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 10069')" onMouseOut="hidetip()" coords="186,47,256,55" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10069" href="/gene/130063497" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 10070')" onMouseOut="hidetip()" coords="188,59,258,67" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10070" href="/gene/130063498" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 13968')" onMouseOut="hidetip()" coords="188,191,258,199" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13968" href="/gene/130063499" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 13969')" onMouseOut="hidetip()" coords="198,71,268,79" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13969" href="/gene/130063500" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 10071')" onMouseOut="hidetip()" coords="203,203,273,211" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10071" href="/gene/130063501" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 10072')" onMouseOut="hidetip()" coords="208,215,278,223" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10072" href="/gene/130063502" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10542553-10543236')" onMouseOut="hidetip()" coords="210,227,280,235" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10542553-10543236" href="/gene/127890430" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10543237-10543919')" onMouseOut="hidetip()" coords="212,239,282,247" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10543237-10543919" href="/gene/127890431" />
<area shape="rect" onMouseOver="showtip(this,event,'phosphodiesterase 4A')" onMouseOut="hidetip()" coords="214,119,352,127" alt="Neighboring gene phosphodiesterase 4A" href="/gene/5141" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr19:10546465-10546964')" onMouseOut="hidetip()" coords="219,251,289,259" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10546465-10546964" href="/gene/127890432" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 13970')" onMouseOut="hidetip()" coords="220,263,290,271" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13970" href="/gene/130063503" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 13971')" onMouseOut="hidetip()" coords="241,23,311,31" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13971" href="/gene/130063504" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 10075')" onMouseOut="hidetip()" coords="251,35,321,43" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10075" href="/gene/130063505" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 10076')" onMouseOut="hidetip()" coords="272,47,342,55" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10076" href="/gene/130063506" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr19:10572008-10572732')" onMouseOut="hidetip()" coords="272,59,342,67" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10572008-10572732" href="/gene/127890433" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 13973')" onMouseOut="hidetip()" coords="310,71,380,79" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13973" href="/gene/130063507" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10602595-10603095')" onMouseOut="hidetip()" coords="337,23,407,31" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10602595-10603095" href="/gene/127890434" />
<area shape="rect" onMouseOver="showtip(this,event,'Sharpr-MPRA regulatory region 8442')" onMouseOut="hidetip()" coords="353,35,423,43" alt="Neighboring gene Sharpr-MPRA regulatory region 8442" href="/gene/125371477" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 13974')" onMouseOut="hidetip()" coords="353,47,423,55" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13974" href="/gene/130063508" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac hESC enhancer GRCh37_chr19:10612744-10613299')" onMouseOut="hidetip()" coords="353,59,423,67" alt="Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10612744-10613299" href="/gene/127890435" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 10078')" onMouseOut="hidetip()" coords="353,83,423,91" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10078" href="/gene/130063509" />
<area shape="rect" onMouseOver="showtip(this,event,'kelch like ECH associated protein 1')" onMouseOut="hidetip()" coords="360,95,423,103" alt="Neighboring gene kelch like ECH associated protein 1" href="/gene/9817" />
</map>
</p>
</div>
</div>
<div class="rprt-section gene-genomic-regions-transcripts-products">
<section class="rprt-section-header" id="genomic-regions-transcripts-products">
<h2 id="header-genomic-regions-transcripts-products">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-regions-transcripts-products .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Genomic regions, transcripts, and products</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Genomic_Regions_Transcripts_a" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<div style="text-align:right;">Go to <a href="#reference-sequences">reference sequence details</a></div>
</div>
<div>
<p class="choose">
<label for="accession" class="label">Genomic Sequence: </label>
<select name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.accessionList" sid="1" id="accessionList" data-taxid="9606" data-geneid="11140">
<option value="NC_000019.10_10391132_10403541">NC_000019.10 Chromosome 19 Reference GRCh38.p14 Primary Assembly</option>
<option value="NC_060943.1_10517574_10529997">NC_060943.1 Chromosome 19 Alternate T2T-CHM13v2.0</option>
<option value="NC_000019.9_10501808_10514217">NC_000019.9 Chromosome 19 Reference GRCh37.p13 Primary Assembly</option>
</select>
</p>
</div>
<div id="NC_000019" class="divAccession">
<div class="seq-viewer">
<p class="note-link">
<strong>Go to nucleotide:</strong>
<a title="Nucleotide Graphic report" href="/nuccore/NC_000019.10?report=graph&amp;from=10389271&amp;to=10405402&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=NC_000019.10">Graphics</a>
<a title="Nucleotide FASTA report" href="/nuccore/NC_000019.10?report=fasta&amp;from=10391133&amp;to=10403542&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=NC_000019.10">FASTA</a>
<a title="Nucleotide GenBank report" href="/nuccore/NC_000019.10?report=genbank&amp;from=10391133&amp;to=10403542&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=NC_000019.10">GenBank</a>
</p>
<div id="divNC_000019" class="SeqViewerApp" style="clear:both;" data-sv="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000019.10&amp;from=10389271&amp;to=10405402&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40">
<a href="?appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000019.10&amp;from=10389271&amp;to=10405402&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40"></a>
</div>
</div>
</div>
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000019.10" sid="1" type="hidden" id="nucleotideLink_NC_000019_10_10391132_10403541" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_000019.10?report=graph&amp;amp;from=10389271&amp;amp;to=10405402&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.40&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=11140&amp;amp;link_uid=NC_000019.10&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_000019.10?report=fasta&amp;amp;from=10391133&amp;amp;to=10403542&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=11140&amp;amp;link_uid=NC_000019.10&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_000019.10?report=genbank&amp;amp;from=10391133&amp;amp;to=10403542&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=11140&amp;amp;link_uid=NC_000019.10&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000019.10" sid="1" type="hidden" id="relString_NC_000019_10_10391132_10403541" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_000019.10&amp;amp;from=10389271&amp;amp;to=10405402&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.40" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_060943.1" sid="1" type="hidden" id="nucleotideLink_NC_060943_1_10517574_10529997" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_060943.1?report=graph&amp;amp;from=10515711&amp;amp;to=10531860&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_009914755.1&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=11140&amp;amp;link_uid=NC_060943.1&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_060943.1?report=fasta&amp;amp;from=10517575&amp;amp;to=10529998&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=11140&amp;amp;link_uid=NC_060943.1&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_060943.1?report=genbank&amp;amp;from=10517575&amp;amp;to=10529998&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=11140&amp;amp;link_uid=NC_060943.1&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_060943.1" sid="1" type="hidden" id="relString_NC_060943_1_10517574_10529997" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_060943.1&amp;amp;from=10515711&amp;amp;to=10531860&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_009914755.1" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000019.9" sid="1" type="hidden" id="nucleotideLink_NC_000019_9_10501808_10514217" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_000019.9?report=graph&amp;amp;from=10499947&amp;amp;to=10516078&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.25&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=11140&amp;amp;link_uid=NC_000019.9&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_000019.9?report=fasta&amp;amp;from=10501809&amp;amp;to=10514218&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=11140&amp;amp;link_uid=NC_000019.9&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_000019.9?report=genbank&amp;amp;from=10501809&amp;amp;to=10514218&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=11140&amp;amp;link_uid=NC_000019.9&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000019.9" sid="1" type="hidden" id="relString_NC_000019_9_10501808_10514217" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_000019.9&amp;amp;from=10499947&amp;amp;to=10516078&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.25" />
</div>
</div>
<div class="rprt-section gene-gene-expression">
<section class="rprt-section-header" id="gene-expression">
<h2 id="header-gene-expression">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-gene-expression .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Expression</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Expression" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<div style="text-align:right;">
<a href="/gene/11140/?report=expression" data-url="/gene/11140/?report=expression" id="gene-expression-see-details">See details</a>
</div>
<div id="gene-expression-app" data-url="https://www.ncbi.nlm.nih.gov/gene/11140" data-report-type="summary">
<div>
<script type="text/javascript">
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<option value="SRP051249" selected="selected" data-bioproject="PRJNA270632">
Tissue-specific circular RNA induction during human fetal development
</option>
<option value="SRP056969" data-bioproject="PRJNA280600">
RNA sequencing of total RNA from 20 human tissues
</option>
<option value="ERP003613" data-bioproject="PRJEB4337">
HPA RNA-seq normal tissues
</option>
</select>
<ul id="project-summary">
<li id="project-summary-title">Project title:
Tissue-specific circular RNA induction during human fetal development
</li>
<li id="project-summary-desc">Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA</li>
<li id="project-summary-bioprojects">BioProject: <a href="/bioproject/PRJNA270632/">PRJNA270632</a>
</li>
<li id="project-summary-pubs">Publication:
<span><a href="/pubmed/26076956/">PMID 26076956</a></span>
</li>
<li id="project-summary-analysis-date">Analysis date: Mon Apr 2 22:54:59 2018</li>
</ul>
<div id="gene-expr-details" class="expression-chart"></div>
</div>
</div>
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<h3 id="relatedarticlesinpubmed">
<a href="#" class="jig-ncbitoggler-open">Related articles in PubMed</a>
</h3>
<div class="generefbl-link">
<ol class="generef-link">
<li>
<a href="/pubmed/28784328/" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=28784328">How Hsp90 and Cdc37 Lubricate Kinase Molecular Switches.</a>
<span class="pubmed-auth-date"> Verba KA, <em>et al</em>. Trends Biochem Sci, 2017 Oct. PMID 28784328, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC5621984/" ref="ordinalpos=0&amp;ncbi_uid=11140&amp;link_uid=PMC5621984">Free PMC Article</a></span></span>
</li>
<li>
<a href="/pubmed/34627434/" ref="ordinalpos=2&amp;ncbi_uid=11140&amp;link_uid=34627434">[Cdc37 Expression in Multiple Myeloma and Its Role in Cell Proliferation].</a>
<span class="pubmed-auth-date"> Zang MR, <em>et al</em>. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2021 Oct. PMID 34627434</span>
</li>
<li>
<a href="/pubmed/12907640/" ref="ordinalpos=3&amp;ncbi_uid=11140&amp;link_uid=12907640">Cdc37 enhances proliferation and is necessary for normal human prostate epithelial cell survival.</a>
<span class="pubmed-auth-date"> Schwarze SR, <em>et al</em>. Cancer Res, 2003 Aug 1. PMID 12907640</span>
</li>
<li>
<a href="/pubmed/35400341/" ref="ordinalpos=4&amp;ncbi_uid=11140&amp;link_uid=35400341">The Therapeutic Potential of Targeting Hsp90-Cdc37 Interactions in Several Diseases.</a>
<span class="pubmed-auth-date"> Zhang X, <em>et al</em>. Curr Drug Targets, 2022. PMID 35400341</span>
</li>
<li>
<a href="/pubmed/25098386/" ref="ordinalpos=5&amp;ncbi_uid=11140&amp;link_uid=25098386">Suppressing the CDC37 cochaperone in hepatocellular carcinoma cells inhibits cell cycle progression and cell growth.</a>
<span class="pubmed-auth-date"> Wang Z, <em>et al</em>. Liver Int, 2015 Apr. PMID 25098386</span>
</li>
</ol>
<p class="see-all-pm">
<a href="/pubmed?LinkName=gene_pubmed&amp;from_uid=11140" title="See all 300 citations in Pubmed">See all (300) citations in PubMed</a>
</p>
</div>
</div>
<div class="generif-pubmed generif">
<h3 id="generifsgenereferencesintofunctions">
<a href="#" class="jig-ncbitoggler-open">GeneRIFs: Gene References Into Functions</a>
</h3>
<div>
<a href="/gene/about-generif" class="whatisthis">What's a GeneRIF?</a>
<div class="generefbl-link">
<ol class="generef-link">
<li class="gene-rif-popper">
<a href="/pubmed/37535399" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=37535399">Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism.</a>
<div id="gene-popper1" class="gene-rif-popper">Title: Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/36446791" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=36446791">HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation.</a>
<div id="gene-popper2" class="gene-rif-popper">Title: HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/35400341" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=35400341">The Therapeutic Potential of Targeting Hsp90-Cdc37 Interactions in Several Diseases.</a>
<div id="gene-popper3" class="gene-rif-popper">Title: The Therapeutic Potential of Targeting Hsp90-Cdc37 Interactions in Several Diseases.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/35165364" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=35165364">Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B.</a>
<div id="gene-popper4" class="gene-rif-popper">Title: Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/34147560" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=34147560">Protein quality control of DYRK family protein kinases by the Hsp90-Cdc37 molecular chaperone.</a>
<div id="gene-popper5" class="gene-rif-popper">Title: Protein quality control of DYRK family protein kinases by the Hsp90-Cdc37 molecular chaperone.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/32656999" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=32656999">Hsp90 interacts with Cdc37, is phosphorylated by PKA/PKC, and regulates Src phosphorylation in human sperm capacitation.</a>
<div id="gene-popper6" class="gene-rif-popper">Title: Hsp90 interacts with Cdc37, is phosphorylated by PKA/PKC, and regulates Src phosphorylation in human sperm capacitation.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/34627434" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=34627434">[Cdc37 Expression in Multiple Myeloma and Its Role in Cell Proliferation].</a>
<div id="gene-popper7" class="gene-rif-popper">Title: [Cdc37 Expression in Multiple Myeloma and Its Role in Cell Proliferation].</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/33374422" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=33374422">The Activity and Stability of p56Lck and TCR Signaling Do Not Depend on the Co-Chaperone Cdc37.</a>
<div id="gene-popper8" class="gene-rif-popper">Title: The Activity and Stability of p56Lck and TCR Signaling Do Not Depend on the Co-Chaperone Cdc37.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/33786814" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=33786814">The CDC37-HSP90 chaperone complex co-translationally degrades the nascent kinase-dead mutant of HIPK2.</a>
<div id="gene-popper9" class="gene-rif-popper">Title: The CDC37-HSP90 chaperone complex co-translationally degrades the nascent kinase-dead mutant of HIPK2.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/31662027" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=31662027">Medium-Throughput Detection of Hsp90/Cdc37 Protein-Protein Interaction Inhibitors Using a Split Renilla Luciferase-Based Assay.</a>
<div id="gene-popper10" class="gene-rif-popper">Title: Medium-Throughput Detection of Hsp90/Cdc37 Protein-Protein Interaction Inhibitors Using a Split Renilla Luciferase-Based Assay.</div>
</li>
</ol>
</div>
<div class="submit-genrif">
<span>Submit:</span>
<a href="/gene/submit-generif/?geneId=11140&amp;sym=CDC37&amp;name=cell division cycle 37, HSP90 cochaperone&amp;org=Homo sapiens">New GeneRIF</a>
<a href="/RefSeq/update.cgi?geneid=11140&amp;symbol=CDC37;task=fixpub">Correction</a>
<a href="https://www.ncbi.nlm.nih.gov/gene?db=gene&amp;report=generif&amp;term=11140" class="seeall-generif">See all GeneRIFs (66)</a>
</div>
</div>
</div>
</div>
</div>
<div class="rprt-section gene-phenotypes">
<section class="rprt-section-header" id="phenotypes">
<h2 id="header-phenotypes">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-phenotypes .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Phenotypes</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Phenotype" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body info-phenotype">
<p class="nochild-link">
<a href="/gtr/tests/?term=CDC37[gene]">Find tests for this gene in the NIH Genetic Testing Registry (GTR)</a>
</p>
<p class="nochild-link">
<a href="/gap/PheGenI?tab=1&amp;gene=11140">Review eQTL and phenotype association data in this region using PheGenI</a>
</p>
<div>
<h3 id="ebigwascatalog">EBI GWAS Catalog</h3>
<table class="jig-ncbigrid gtr-associated-cond" data-jigconfig="isPageable: true, pageSize: 10">
<thead>
<tr>
<th class="description">Description</th>
</tr>
</thead>
<tbody>
<tr>
<td>Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/21833088">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/21833088">PubMed</a></span></div></div></div></td>
</tr>
<tr>
<td>Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/23128233">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/23128233">PubMed</a></span></div></div></div></td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<div class="rprt-section gene-variation">
<section class="rprt-section-header" id="variation">
<h2 id="header-variation">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-variation .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Variation</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.variation" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<p class="nochild-link">
<a href="/clinvar/?term=CDC37[gene]" ref="log$=recordlinks">See variants in ClinVar</a>
</p>
<p class="nochild-link">
<a href="/dbvar?LinkName=gene_dbvar&amp;from_uid=11140" ref="log$=recordlinks">See studies and variants in dbVar</a>
</p>
<p class="nochild-link">
<a href="/variation/view/?q=11140[geneid]&amp;assm=GCF_000001405.25" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh37.p13)">See Variation Viewer (GRCh37.p13)</a>
</p>
<p class="nochild-link">
<a href="/variation/view/?q=11140[geneid]" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh38)">See Variation Viewer (GRCh38)</a>
</p>
<set></set>
<set></set>
</div>
</div>
<div class="rprt-section gene-HIV-1-interactions">
<section class="rprt-section-header" id="HIV-1-interactions">
<h2 id="header-HIV-1-interactions">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-HIV-1-interactions .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">HIV-1 interactions</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.HIV1_interactions" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div class="fgrid">
<h3 id="proteininteractions">Protein interactions</h3>
<table summary="protein interactions" class="jig-ncbigrid">
<thead>
<tr>
<th id="hivprotein">Protein</th>
<th id="gene-hivprotein">Gene</th>
<th id="hivinter">Interaction</th>
<th id="hivpub">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="hivprotein">
<a href="/protein/9629358">Tat</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">Hsp70 and Hsp90 and Cdc37 regulate the stabilization and folding of CDK9 as well as the assembly of an active CDK9/cyclin T1 complex responsible for P-TEFb-mediated HIV-1 Tat transactivation</td>
<td headers="hivpub">
<a title="PubMed Id(s): 10617616" href="/pubmed/10617616">PubMed</a>
</td>
</tr>
</tbody>
</table>
<p class="withnote">
<a class="note" href="/genome/viruses/retroviruses/hiv-1/interactions/">Go to the HIV-1, Human Interaction Database </a>
</p>
</div>
</div>
</div>
<div class="rprt-section gene-pathways">
<section class="rprt-section-header" id="pathways">
<h2 id="header-pathways">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-pathways .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Pathways from PubChem</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<ul class="geneinfo-subsec infopathway">
<iframe title="Pathways in which the gene target is involved" class="pubchem-widget" scrolling="no" src="https://pubchem.ncbi.nlm.nih.gov/gene/11140#section=Pathways&amp;embed=true&amp;hide_all_headings=true&amp;page_size=25" style="border: 0; width: 100%;"></iframe>
<script type="text/javascript" src="https://pubchem.ncbi.nlm.nih.gov/pcfe/libs/iframeResizer.min.js"></script>
<script type="text/javascript">iFrameResize({log: false, checkOrigin: false}, '.pubchem-widget')</script>
</ul>
</div>
</div>
<div class="rprt-section gene-interactions">
<section class="rprt-section-header" id="interactions">
<h2 id="header-interactions">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-interactions .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Interactions</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Interactions" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<table summary="Gene Interaction" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/11140/data/interaction/',webserviceParams: 'p$l=Ajax&amp;p$debugoutput=off', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
<thead>
<tr>
<th id="inter-prod">Products</th>
<th id="inter-interactant">Interactant</th>
<th id="inter-otherGene">Other Gene</th>
<th id="inter-compl">Complex</th>
<th id="inter-source">Source</th>
<th id="inter-pubs">Pubs</th>
<th id="inter-desc">Description</th>
</tr>
</thead>
<tbody></tbody>
</table>
</div>
</div>
<div class="rprt-section gene-general-gene-info">
<section class="rprt-section-header" id="general-gene-info">
<h2 id="header-general-gene-info">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-gene-info .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">General gene information</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.General_Gene_Information" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body" style="">
<div id="gene-markers">
<h3 id="markers">
<a class="jig-ncbitoggler">Markers</a>
</h3>
<div>
<ul class="marker odd">
<li class="marker">RH41901 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=51987%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=51987">UniSTS:51987</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">RH80833 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=89945%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=89945">UniSTS:89945</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">NoName (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=486773%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=486773">UniSTS:486773</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">RH101844 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=41856%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=41856">UniSTS:41856</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">D19S1108 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=44424%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=44424">UniSTS:44424</a></li></ul></li>
</ul>
</div>
</div>
<div>
<div class="infosec" id="Relatedpseudogenes"><h3 id="relatedpseudogenes"><a class="jig-ncbitoggler-open">Related pseudogene(s)</a></h3>
<dl class="geneinfo-subsec"><dt>3 found
 
<a href="/gene/?Term=related_functional_gene_11140%5Bgroup%5D">Review record(s) in Gene</a></dt></dl>
</div>
</div>
<div class="infosec">
<h3 id="homology">
<a class="jig-ncbitoggler-open">Homology</a>
</h3>
<ul class="geneinfo-subsec">
<li>
<a href="/gene/11140/ortholog/" id="ncbi-ortholog-link">NCBI Orthologs</a>
</li>
<a href="https://www.orthodb.org/?ncbi=11140" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8178" target="_blank">
Orthologs from OrthoDB
</a>
</ul>
</div>
<!--<component id="Gene_InfoPathway"/>-->
<div class="gene-ontology infosec">
<h3 id="gene-ontology">
<a class="jig-ncbitoggler-open">
<span>Gene Ontology</span>
</a>
<a target="_blank" href="http://www.ebi.ac.uk/GOA" class="g-ontology-src" title="Provided by GOA">Provided by GOA</a>
</h3>
<div class="ontology-tables">
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Function</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0051879">enables Hsp90 protein binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-1-0" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0031072">enables heat shock protein binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-2-0" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0031072">enables heat shock protein binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-3-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/9660753" target="_blank" title="PubMed ID 9660753" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=9660753">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0019900">enables kinase binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-4-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/21855797" target="_blank" title="PubMed ID 21855797" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=21855797">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005515">enables protein binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-5-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/9150368,11036079,12176997,14676191,14743216,16321986,17979178,19026643,19875381,20562859,20642453,21163940,21360678,21871133,21900206,21903422,22612223,22939624,23075850,23428871,23455922,24189400,24366813,24618592,24880080,24981860,25036637,25486457,26496610,27086506,27339980,27353360,28330616,28514442,29433126,29568061,30108113,30833792,31046837,31980649,32296183,32707033,33961781,34591612,35271311,35384245,36217029,37045861" target="_blank" title="PubMed ID 9150368,11036079,12176997,14676191,14743216,16321986,17979178,19026643,19875381,20562859,20642453,21163940,21360678,21871133,21900206,21903422,22612223,22939624,23075850,23428871,23455922,24189400,24366813,24618592,24880080,24981860,25036637,25486457,26496610,27086506,27339980,27353360,28330616,28514442,29433126,29568061,30108113,30833792,31046837,31980649,32296183,32707033,33961781,34591612,35271311,35384245,36217029,37045861" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=9150368,11036079,12176997,14676191,14743216,16321986,17979178,19026643,19875381,20562859,20642453,21163940,21360678,21871133,21900206,21903422,22612223,22939624,23075850,23428871,23455922,24189400,24366813,24618592,24880080,24981860,25036637,25486457,26496610,27086506,27339980,27353360,28330616,28514442,29433126,29568061,30108113,30833792,31046837,31980649,32296183,32707033,33961781,34591612,35271311,35384245,36217029,37045861">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0019901">enables protein kinase binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-6-0" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0019887">enables protein kinase regulator activity</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-7-0" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0051087">enables protein-folding chaperone binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-8-0" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0097110">enables scaffold protein binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-9-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/10409742" target="_blank" title="PubMed ID 10409742" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=10409742">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0051082">enables unfolded protein binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-10-0" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
</tbody>
</table>
</div>
</div>
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Process</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:1905091">involved_in positive regulation of type 2 mitophagy</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-1-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0010608">involved_in post-transcriptional regulation of gene expression</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-2-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0006457">involved_in protein folding</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-3-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0050821">involved_in protein stabilization</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-4-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0006605">involved_in protein targeting</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-5-1" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/8666233" target="_blank" title="PubMed ID 8666233" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=8666233">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0000079">involved_in regulation of cyclin-dependent protein serine/threonine kinase activity</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-6-1" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/8666233" target="_blank" title="PubMed ID 8666233" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=8666233">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0060338">acts_upstream_of_or_within regulation of type I interferon-mediated signaling pathway</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-7-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/16280321" target="_blank" title="PubMed ID 16280321" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=16280321">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0060334">acts_upstream_of_or_within regulation of type II interferon-mediated signaling pathway</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-8-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/16280321" target="_blank" title="PubMed ID 16280321" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=16280321">PubMed</a> </td>
</tr>
</tbody>
</table>
</div>
</div>
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-config="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Component</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:1990565">part_of HSP90-CDC37 chaperone complex</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-1-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/21855797" target="_blank" title="PubMed ID 21855797" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=21855797">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005737">is_active_in cytoplasm</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-2-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005737">located_in cytoplasm</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-3-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005829">located_in cytosol</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-4-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005829">located_in cytosol</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-5-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0070062">located_in extracellular exosome</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> HDA</a>
<div id="evidence-code-6-2" class="ecode">
<br />
<a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a>
</div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/20458337" target="_blank" title="PubMed ID 20458337" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=20458337">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0101031">part_of protein folding chaperone complex</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-7-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/29127155" target="_blank" title="PubMed ID 29127155" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=29127155">PubMed</a> </td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
</div>
</div>
</div>
<div class="rprt-section gene-general-protein-info">
<section class="rprt-section-header" id="general-protein-info">
<h2 id="header-general-protein-info">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-protein-info .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">General protein information</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.General_Protein_Information" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<dl>
<dt>Preferred Names</dt>
<dd>hsp90 co-chaperone Cdc37</dd>
</dl>
<dl>
<dt>Names</dt>
<dd>CDC37 (cell division cycle 37, S. cerevisiae, homolog)</dd>
<dd>CDC37 cell division cycle 37 homolog</dd>
<dd>cell division cycle 37 homolog</dd>
<dd>hsp90 chaperone protein kinase-targeting subunit</dd>
</dl>
</div>
</div>
<div class="rprt-section gene-reference-sequences">
<section class="rprt-section-header" id="reference-sequences">
<h2 id="header-reference-sequences">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-reference-sequences .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">NCBI Reference Sequences (RefSeq)</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.NCBI_Reference_Sequences_RefS" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<p>
<span class="new-icon">NEW</span>
<strong>Try the new <a href="/datasets/tables/genes/?table_type=transcripts&amp;ids=11140&amp;utm_source=gene&amp;utm_medium=referral&amp;utm_campaign=refseq" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report." data-ga-category="refseq" data-ga-action="click_datasets_link" data-ga-label="transcript_table">Transcript table</a></strong>
</p>
<h3 class="genomerefseqs gene_std_toggler" id="refseqset-independent">
<a class="jig-ncbitoggler-open">RefSeqs maintained independently of Annotated
Genomes</a>
</h3>
<div class="genomerefseqs_slave">
<p class="desc"> These reference sequences exist independently of genome builds. <a href="#refseq-expl" id="expl-refseg">Explain</a></p>
<p id="refseq-expl"> These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in <a href="#geneGenomic regions, transcripts, and products">Genomic regions,
transcripts, and products</a> above. </p>
<h4 id="mrnaandproteins-p85824880">mRNA and Protein(s) </h4>
<ol>
<li>
<p><a href="/nuccore/NM_007065.4">NM_007065.4</a><a href="/protein/NP_008996.1">NP_008996.1</a>  hsp90 co-chaperone Cdc37</p>
<p>
<a href="/ipg/NP_008996.1/" ref="ncbi_uid=11140">See identical proteins and their annotated locations for NP_008996.1</a>
</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/BC000083, BE796008">BC000083, BE796008</a>
</dd>
<dt>Consensus CDS</dt>
<dd>
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&amp;GO=MainBrowse&amp;DATA=CCDS12237.1">CCDS12237.1</a>
</dd>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/Q16543" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=11140&amp;nlmid=&amp;db=gene">Q16543</a>, <a href="https://www.uniprot.org/uniprot/Q53YA2" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=11140&amp;nlmid=&amp;db=gene">Q53YA2</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/Q6FG59" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=11140&amp;nlmid=&amp;db=gene">Q6FG59</a>
</dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000222005.1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=11140&amp;nlmid=&amp;db=gene">ENSP00000222005.1</a>, <a href="http://www.ensembl.org/id/ENST00000222005.7" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=11140&amp;nlmid=&amp;db=gene">ENST00000222005.7</a></dd>
<dt class="clear"> Conserved Domains (3) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_008996.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=198139">smart01071</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1</span><span class="cddto">127</span></dt>
<dd class="clearfix"> CDC37_N; Cdc37 N terminal kinase binding</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=215009">smart01069</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">287</span><span class="cddto">377</span></dt>
<dd class="clearfix"> CDC37_C; Cdc37 C terminal domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=215010">smart01070</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">133</span><span class="cddto">275</span></dt>
<dd class="clearfix"> CDC37_M; Cdc37 Hsp90 binding domain</dd>
</dl>
</dd>
</dl>
</li>
</ol>
</div>
<h3 class="genomerefseqs gene_std_toggler" id="annotatedrefseq-title">
<a class="jig-ncbitoggler-open">RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08</a>
</h3>
<div class="genomerefseqs_slave">
<p class="desc"> The following sections contain reference sequences that belong to a
specific genome build. <a href="#" id="expl-genomes">Explain</a></p>
<p id="expl-genomes-desc" style="display:none">This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.</p>
<h3 id="refseq-sequencedescription-p119252320">Reference GRCh38.p14 Primary Assembly</h3>
<h4 id="genomic-p119252320">Genomic </h4>
<ol>
<li>
<p>NC_000019.10 Reference GRCh38.p14 Primary Assembly</p>
<dl>
<dt>Range</dt>
<dd class="rs-range">
<span>10391133..10403542 complement</span>
</dd>
<dt>Download</dt>
<dd><a href="/nuccore/NC_000019.10?from=10391133&amp;to=10403542&amp;report=genbank&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=NC_000019.10?from=10391133&amp;to=10403542&amp;report=genbank&amp;strand=true">GenBank</a>, <a href="/nuccore/NC_000019.10?from=10391133&amp;to=10403542&amp;report=fasta&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=NC_000019.10?from=10391133&amp;to=10403542&amp;report=fasta&amp;strand=true">FASTA</a>, <a href="/nuccore/NC_000019.10?from=10389271&amp;to=10405402&amp;report=graph&amp;content=5&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=NC_000019.10?from=10389271&amp;to=10405402&amp;report=graph&amp;content=5&amp;strand=true">Sequence Viewer (Graphics)</a></dd>
</dl>
</li>
</ol>
<h3 id="refseq-sequencedescription-p136736848">Alternate T2T-CHM13v2.0</h3>
<h4 id="genomic-p136736848">Genomic </h4>
<ol>
<li>
<p>NC_060943.1 Alternate T2T-CHM13v2.0</p>
<dl>
<dt>Range</dt>
<dd class="rs-range">
<span>10517575..10529998 complement</span>
</dd>
<dt>Download</dt>
<dd><a href="/nuccore/NC_060943.1?from=10517575&amp;to=10529998&amp;report=genbank&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=NC_060943.1?from=10517575&amp;to=10529998&amp;report=genbank&amp;strand=true">GenBank</a>, <a href="/nuccore/NC_060943.1?from=10517575&amp;to=10529998&amp;report=fasta&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=NC_060943.1?from=10517575&amp;to=10529998&amp;report=fasta&amp;strand=true">FASTA</a>, <a href="/nuccore/NC_060943.1?from=10515711&amp;to=10531860&amp;report=graph&amp;content=5&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=NC_060943.1?from=10515711&amp;to=10531860&amp;report=graph&amp;content=5&amp;strand=true">Sequence Viewer (Graphics)</a></dd>
</dl>
</li>
</ol>
</div>
</div>
</div>
<div class="rprt-section gene-related-sequences">
<section class="rprt-section-header" id="related-sequences">
<h2 id="header-related-sequences">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-related-sequences .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Related sequences</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Related_Sequences" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<table id="proteinTblId" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/11140/data/related-sequences/',webserviceParams: 'p$l=Ajax', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
<thead>
<tr>
<th colspan="2" id="rs-nucleo">Nucleotide</th>
<th rowspan="2" id="rs-protein">Protein</th>
</tr>
<tr>
<th id="rs-heading">Heading</th>
<th id="rs-heading-acc">Accession and Version</th>
</tr>
</thead>
<tbody></tbody>
</table>
<table id="proteinTblId" class="jig-ncbigrid" data-jigconfig="isPageable:true, pageSize:25">
<thead>
<tr>
<th class="proteinTblTh" rowspan="2" id="rs-prot-acc">Protein Accession</th>
<th class="proteinTblTh" colspan="2" id="rs-link">Links</th>
</tr>
<tr>
<th id="rs-genepept">GenPept Link</th>
<th id="rs-uniprot">UniProtKB Link</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="rs-prot-acc">Q16543.1</td>
<td headers="rs-link rs-genepept">
<a href="/protein/21542000" ref="ordinalpos=1&amp;ncbi_uid=11140&amp;link_uid=21542000">GenPept</a>
</td>
<td>
<a href="https://www.uniprot.org/uniprot/Q16543">UniProtKB/Swiss-Prot:Q16543</a>
</td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<div class="rprt-section gene-additional-links">
<section class="rprt-section-header" id="additional-links"><h2 id="header-additional-links"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-additional-links .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Additional links</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Additional_Links" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
<div class="rprt-section-body" style="">
<h3 class="withnote" id="genelinkout">
<a class="jig-ncbitoggler">Gene LinkOut</a>
</h3><div>
<p>The following <a href="https://www.ncbi.nlm.nih.gov/projects/linkout/index.html">LinkOut</a> resources are supplied by external providers. These providers are responsible for maintaining the links. </p>
<div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Chemical Information</span>
</a>
<ul>
<li><span class="free-rsc"></span>Interologous Interaction Database</li>
<ul>
<li>
<a target="_blank" href="http://ophid.utoronto.ca/redirect/ncbi/human?proteins=11140" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7911">
<span>Interologous Interaction Database</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>MilliporeSigma</li>
<ul>
<li>
<a target="_blank" href="https://www.sigmaaldrich.com/catalog/genes/CDC37?lang=en&amp;region=US" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9978">
<span>Cdc37 products</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Molecular Biology Databases</span>
</a>
<ul>
<li><span class="free-rsc"></span>Bgee database</li>
<ul>
<li>
<a target="_blank" href="https://www.bgee.org/gene/ENSG00000105401" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10418">
<span>CDC37 gene expression</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>BioGPS</li>
<ul>
<li>
<a target="_blank" href="http://biogps.org/gene/11140/" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5059">
<span>BioGPS</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>BioGRID Open Repository of CRISPR Screens (ORCS)</li>
<ul>
<li>
<a target="_blank" href="https://orcs.thebiogrid.org/Gene/11140" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10164">
<span>BioGRID CRISPR Screen Phenotypes (817 hits/1357 screens)</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>CTD: Comparative Toxicogenomics Database</li>
<ul>
<li>
<a target="_blank" href="http://ctdbase.org/detail.go?type=gene&amp;acc=11140" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7845">
<span>CTD: Comparative Toxicogenomics Database - CDC37</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Domain Mapping of Disease Mutations</li>
<ul>
<li>
<a target="_blank" href="http://bioinf.umbc.edu/DMDM/gene_prot_page.php?id=11140" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7642">
<span>CDC37</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Eukaryotic Promoter Database</li>
<ul>
<li>
<a target="_blank" href="http://epd.vital-it.ch/cgi-bin/get_doc?db=hgEpdNew&amp;format=genome&amp;entry=CDC37_1" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9624">
<span>CDC37_1</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>GlyGen glycoinformatics resource</li>
<ul>
<li>
<a target="_blank" href="https://glygen.org/protein/Q16543" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10227">
<span>GlyGen glycoinformatics resource</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Human eFP Browser</li>
<ul>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Nervous&amp;modeInput=Absolute&amp;primaryGene=11140" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Skeletal_Immune_Digestive&amp;modeInput=Absolute&amp;primaryGene=11140" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Circulatory_Respiratory&amp;modeInput=Absolute&amp;primaryGene=11140" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
</ul>
<li>Ingenuity Pathways Analysis</li>
<ul>
<li>
<a target="_blank" href="http://partnersolution.ingenuity.com/?cid=97ae3f91eab87a&amp;p1=Entrez&amp;p2=GV&amp;s=&amp;ipaUri=%2Fpa%2Fapi%2Fv2%2Fgeneview%3Fapplicationname%3DEntrez%26geneId%3D11140%26geneidtype%3Dentrezgene" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5628">
<span>Ingenuity Pathways Analysis</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>InnateDB</li>
<ul>
<li>
<a target="_blank" href="http://www.innatedb.com/getGeneCard.do?id=27267" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7894">
<span>InnateDB</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>InterMine</li>
<ul>
<li>
<a target="_blank" href="https://www.humanmine.org/humanmine/search?keyword=ENSG00000105401" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9169">
<span>InterMine</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Kyoto Encyclopedia of Genes and Genomes</li>
<ul>
<li>
<a target="_blank" href="http://www.genome.jp/dbget-bin/www_bget?hsa:11140" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5174">
<span>Kyoto Encyclopedia of Genes and Genomes</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>OMA Browser: Orthologous MAtrix</li>
<ul>
<li>
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN40657/" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9822">
<span>OMA Browser: Orthologous MAtrix</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>OrthoDB catalog of orthologs</li>
<ul>
<li>
<a target="_blank" href="https://www.orthodb.org/?ncbi=11140" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8178">
<span>Orthologs</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>PhosphoSitePlus</li>
<ul>
<li>
<a target="_blank" href="https://www.phosphosite.org/entrezGeneIdAction.action?id=11140" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7987">
<span>PhosphoSitePlus® - comprehensive post-translational modification resource</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>The Gene Wiki</li>
<ul>
<li>
<a target="_blank" href="https://en.wikipedia.org/wiki/CDC37" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=6933">
<span>The Gene Wiki</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>The Weizmann Institute of Science GeneCards and MalaCards databases</li>
<ul>
<li>
<a target="_blank" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=CDC37" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8598">
<span>GeneCard for CDC37</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Research Materials</span>
</a>
<ul>
<li><span class="order-rsc"></span>Addgene Non-profit plasmid repository</li>
<ul>
<li>
<a target="_blank" href="https://addgene.org//browse/gene/11140" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5304">
<span>Get Plasmids - Addgene</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>Bio-Techne</li>
<ul>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/cdc37/antibodies?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=antibodies" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>CDC37 Antibodies</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/cdc37/proteins-enzymes?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=proteins" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>CDC37 Proteins</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/cdc37/lysates?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=lysates" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>CDC37 Lysates</span>
</a>
</li>
</ul>
<li>ExactAntigen/Labome</li>
<ul>
<li>
<a target="_blank" href="https://www.labome.com/review/gene/human/CDC37-antibody.html" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5753">
<span>reagent review</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.labome.com/gene/human/CDC37-antibody.html" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5753">
<span>reagents</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GenScript latest version of gene cDNA ORF Clone</li>
<ul>
<li>
<a target="_blank" href="http://www.genscript.com/gene/11140" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8012">
<span>GenScript latest version of gene cDNA ORF Clone</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GeneCopoeia Inc.</li>
<ul>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=26&amp;field=5&amp;key=11140" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order TALEN/CRISPR clones</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?tax_id=9606&amp;field=5&amp;prt=16&amp;key=11140" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order miRNA target clones</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=1&amp;field=5&amp;key=11140" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order full-length ORF clone</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GeneTex Inc</li>
<ul>
<li>
<a target="_blank" href="https://www.genetex.com/Product/Search?geneid=11140&amp;type=01&amp;page=1" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8117">
<span>Find Quality Antibodies</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.genetex.com/Product/Search?geneid=11140&amp;type=03&amp;page=1" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8117">
<span>Find Recombinant Proteins and Peptides</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>Kazusa DNA Research Institute</li>
<ul>
<li>
<a target="_blank" href="http://www.kazusa.or.jp/kop/dsearch/symsearch.cgi?keyword=CDC37;" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=3267">
<span>Kazusa DNA Research Institute</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>OriGene</li>
<ul>
<li>
<a target="_blank" href="https://www.origene.com/search?q=Cdc37" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7994">
<span>Order Cdc37 cDNA clone/Protein/Antibody/RNAi</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Tools</span>
</a>
<ul>
<li><span class="free-rsc"></span>GeneMANIA</li>
<ul>
<li>
<a target="_blank" href="http://genemania.org/link?o=9606&amp;g=11140" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7529">
<span>GeneMANIA</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open">
<span>Miscellaneous</span>
</a>
<ul>
<li><span class="free-rsc"></span>Reactome</li>
<ul>
<li>
<a target="_blank" href="https://reactome.org/PathwayBrowser/#/R-HSA-5357801" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=4914">
<span>Reactome Event:Programmed Cell Death</span>
</a>
</li>
<li>
<a target="_blank" href="https://reactome.org/PathwayBrowser/#/R-HSA-162582" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=4914">
<span>Reactome Event:Signal Transduction</span>
</a>
</li>
<li>
<a target="_blank" href="https://reactome.org/content/query?q=UniProt:Q16543" ref="itool=Gene_FullReport&amp;uid=11140&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=4914">
<span>Reactome Entity:Q16543</span>
</a>
</li>
</ul>
</ul>
</div>
</div>
</div>
<div id="urls-in-genombrowser" style="display:none">
</div>
</div>
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</div>
<div class=" bottom">
</div>
</div>
</div>
<div class="supplemental col three_col last" id="sidebar_tabular">
<!-- sidebar close/hide button-->
<div class="ui-helper-clearfix">
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<h2 class="offscreen_noflow">Supplemental Content</h2>
<div id="gene-sidebar">
<div>
<div class="portlet brieflink dis-table-of-contents">
<div class="portlet_head">
<div class="portlet_title">
<h3>Table of contents</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_TableOfContents" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li class="">
<a href="#summary">Summary</a>
</li>
<li class="">
<a href="#genomic-context">Genomic context</a>
</li>
<li class="">
<a href="#genomic-regions-transcripts-products">Genomic regions, transcripts, and products</a>
</li>
<li class="">
<a href="#gene-expression">Expression</a>
</li>
<li class="">
<a href="#bibliography">Bibliography</a>
</li>
<li class="">
<a href="#phenotypes">Phenotypes</a>
</li>
<li class="">
<a href="#variation">Variation</a>
</li>
<li class="">
<a href="#HIV-1-interactions">HIV-1 interactions</a>
</li>
<li class="">
<a href="#pathways">Pathways from PubChem</a>
</li>
<li class="">
<a href="#interactions">Interactions</a>
</li>
<li class="">
<a href="#general-gene-info">General gene information</a>
<div class="subsection-links"><a href="#gene-markers">Markers</a>, <a href="#Relatedpseudogenes">Related pseudogene(s)</a>, <a href="#homology">Homology</a>, <a href="#gene-ontology">Gene Ontology</a></div>
</li>
<li class="">
<a href="#general-protein-info">General protein information</a>
</li>
<li class="">
<a href="#reference-sequences">NCBI Reference Sequences (RefSeq)</a>
</li>
<li class="">
<a href="#related-sequences">Related sequences</a>
</li>
<li class="">
<a href="#additional-links">Additional links</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-genomesbrowser brieflink dis-genomesbrowser">
<div class="portlet_head">
<div class="portlet_title">
<h3>Genome Browsers</h3>
</div>
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</div>
<div class="portlet_content">
<ul>
<li>
<a href="#">Loading...</a>
</li>
</ul>
</div>
</div>
<div class="portlet dis-related-info brieflink">
<div class="portlet_head">
<div class="portlet_title">
<h3>Related information</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter"></a>
</div>
<div class="portlet_content DiscoveryDbLinks">
<ul>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clone/order/gene/11140" ref="log$=recordlinks">Order cDNA clone</a>
<div class="brieflinkpop offscreen_noflow">Order cDNA clone</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/structure?LinkName=gene_structure&amp;from_uid=11140" ref="log$=recordlinks">3D structures</a>
<div class="brieflinkpop offscreen_noflow">3D structure of a gene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_alltarget_list&amp;from_uid=11140" ref="log$=recordlinks">BioAssay by Target (List)</a>
<div class="brieflinkpop offscreen_noflow">BioAssays related to the gene by protein target or RNAi target</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="//pubchem.ncbi.nlm.nih.gov/assay/bioactivity.html?geneid=11140" ref="log$=recordlinks">BioAssay by Target (Summary)</a>
<div class="brieflinkpop offscreen_noflow">Summarized PubChem Data on the gene, showing the active data by default</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_target&amp;from_uid=11140" ref="log$=recordlinks">BioAssay, by Gene target</a>
<div class="brieflinkpop offscreen_noflow">PubChem BioAssays done on the Gene target</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai_active&amp;from_uid=11140" ref="log$=recordlinks">BioAssays, RNAi Target, Active</a>
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent, which is identified as a hit in a RNAi screening and flagged as "active" in the corresponding BioAssay record</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai&amp;from_uid=11140" ref="log$=recordlinks">BioAssays, RNAi Target, Tested</a>
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/bioproject?LinkName=gene_bioproject&amp;from_uid=11140" ref="log$=recordlinks">BioProjects</a>
<div class="brieflinkpop offscreen_noflow">BioProjects related to a gene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/biosystems?LinkName=gene_biosystems&amp;from_uid=11140" ref="log$=recordlinks">BioSystems</a>
<div class="brieflinkpop offscreen_noflow">BioSystems</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/CCDS/CcdsBrowse.cgi?REQUEST=GENEID&amp;DATA=11140" ref="log$=recordlinks">CCDS</a>
<div class="brieflinkpop offscreen_noflow">Link to CCDS</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar&amp;from_uid=11140" ref="log$=recordlinks">ClinVar</a>
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/cdd?LinkName=gene_cdd&amp;from_uid=11140" ref="log$=recordlinks">Conserved Domains</a>
<div class="brieflinkpop offscreen_noflow">Related CDD</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/dbvar?LinkName=gene_dbvar&amp;from_uid=11140" ref="log$=recordlinks">dbVar</a>
<div class="brieflinkpop offscreen_noflow">Link from Gene to dbVar</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc&amp;from_uid=11140" ref="log$=recordlinks">Full text in PMC</a>
<div class="brieflinkpop offscreen_noflow">PMC links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc_nucleotide&amp;from_uid=11140" ref="log$=recordlinks">Full text in PMC_nucleotide</a>
<div class="brieflinkpop offscreen_noflow">Full text in PubMedCentral identified from shared sequence links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/sparcle?LinkName=gene_sparcle&amp;from_uid=11140" ref="log$=recordlinks">Functional Class</a>
<div class="brieflinkpop offscreen_noflow">Functional class of the sequence domain architecture</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gene?LinkName=gene_gene_neighbors&amp;from_uid=11140" ref="log$=recordlinks">Gene neighbors</a>
<div class="brieflinkpop offscreen_noflow">Overlapping genes and two nearest non-overlapping genes on either side</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gene?LinkName=gene_gene_h3k4me3&amp;from_uid=11140" ref="log$=recordlinks">Genes with a similar H3K4me3 profile</a>
<div class="brieflinkpop offscreen_noflow">Genes with a similar profile of promoter-activating H3K4me3 modifications across several tissue types</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/genome?LinkName=gene_genome&amp;from_uid=11140" ref="log$=recordlinks">Genome</a>
<div class="brieflinkpop offscreen_noflow">Related Genome</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/geoprofiles?LinkName=gene_geoprofiles&amp;from_uid=11140" ref="log$=recordlinks">GEO Profiles</a>
<div class="brieflinkpop offscreen_noflow">Related GEO</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gtr/tests/?term=11140[geneid]" ref="log$=recordlinks">GTR</a>
<div class="brieflinkpop offscreen_noflow">Tests for this gene in the NIH Genetic Testing Registry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/homologene?LinkName=gene_homologene&amp;from_uid=11140" ref="log$=recordlinks">HomoloGene</a>
<div class="brieflinkpop offscreen_noflow">Related HomoloGene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore&amp;from_uid=11140" ref="log$=recordlinks">Nucleotide</a>
<div class="brieflinkpop offscreen_noflow">Link to related Nucleotide entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/omim?LinkName=gene_omim&amp;from_uid=11140" ref="log$=recordlinks">OMIM</a>
<div class="brieflinkpop offscreen_noflow">Link to related OMIM entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/probe?LinkName=gene_probe&amp;from_uid=11140" ref="log$=recordlinks">Probe</a>
<div class="brieflinkpop offscreen_noflow">Related Probe entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein&amp;from_uid=11140" ref="log$=recordlinks">Protein</a>
<div class="brieflinkpop offscreen_noflow">Link to related protein entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pccompound?LinkName=gene_pccompound&amp;from_uid=11140" ref="log$=recordlinks">PubChem Compound</a>
<div class="brieflinkpop offscreen_noflow">PubChem Compounds</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcsubstance?LinkName=gene_pcsubstance&amp;from_uid=11140" ref="log$=recordlinks">PubChem Substance</a>
<div class="brieflinkpop offscreen_noflow">PubChem Substances</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed&amp;from_uid=11140" ref="log$=recordlinks">PubMed</a>
<div class="brieflinkpop offscreen_noflow">Link to related PubMed entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_rif&amp;from_uid=11140" ref="log$=recordlinks">PubMed (GeneRIF)</a>
<div class="brieflinkpop offscreen_noflow">Link to related PubMed article from GeneRIFs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_citedinomim&amp;from_uid=11140" ref="log$=recordlinks">PubMed (OMIM)</a>
<div class="brieflinkpop offscreen_noflow">Gene links to PubMed derived from omim_pubmed_cited links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_pmc_nucleotide&amp;from_uid=11140" ref="log$=recordlinks">PubMed(nucleotide/PMC)</a>
<div class="brieflinkpop offscreen_noflow">Citations in PubMed identified from shared sequence and PMC links.</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein_refseq&amp;from_uid=11140" ref="log$=recordlinks">RefSeq Proteins</a>
<div class="brieflinkpop offscreen_noflow">Link to Protein RefSeqs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore_refseqrna&amp;from_uid=11140" ref="log$=recordlinks">RefSeq RNAs</a>
<div class="brieflinkpop offscreen_noflow">Link to Nucleotide RefSeq RNAs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/snp?LinkName=gene_snp&amp;from_uid=11140" ref="log$=recordlinks">SNP</a>
<div class="brieflinkpop offscreen_noflow">Related SNP records</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/taxonomy?LinkName=gene_taxonomy&amp;from_uid=11140" ref="log$=recordlinks">Taxonomy</a>
<div class="brieflinkpop offscreen_noflow">Link to related taxonomy entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/variation/view/?q=11140[geneid]" ref="log$=recordlinks">Variation Viewer</a>
<div class="brieflinkpop offscreen_noflow">Related Variants</div>
</li>
</ul>
</div>
</div>
<div class="portlet dis-links-to-other-res brieflink">
<div class="portlet_head">
<div class="portlet_title">
<h3>Links to other resources</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_LinksTwo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1735">HGNC</a>
</li>
<li>
<a href="http://www.ensembl.org/id/ENSG00000105401">Ensembl</a>
</li>
<li>
<a href="https://www.alliancegenome.org/gene/HGNC:1735">AllianceGenome</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=geneid&amp;org=9606&amp;l=11140">AceView</a>
</li>
<li>
<a href="http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&amp;position=NM_007065">UCSC</a>
</li>
<li>
<a href="https://genecollections.nci.nih.gov/MGC/?ORG=Hs&amp;LIST=BC000083,BC008793">MGC</a>
</li>
<li>
<a href="https://phgkb.cdc.gov/PHGKB/huGEPedia.action?firstQuery=CDC37&amp;geneID=11140&amp;typeOption=gene&amp;which=2&amp;pubOrderType=pubD&amp;typeSubmit=GO&amp;check=y">HuGE Navigator</a>
</li>
<li>
<a href="http://www.genome.jp/dbget-bin/www_bget?hsa:11140">KEGG</a>
</li>
<li>
<a href="https://reactome.org/content/query?q=UniProt:Q16543">Reactome</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-general-info">
<div class="portlet_head">
<div class="portlet_title">
<h3>General information</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GeneralInfo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="/pmc/?term=PMC4383897+OR+PMC3013746+OR+PMC1761442+OR+PMC539985">About Gene</a>
</li>
<li>
<a href="/books/NBK3840">FAQ</a>
</li>
<li>
<a href="https://ftp.ncbi.nlm.nih.gov/gene/">FTP site</a>
</li>
<li>
<a href="/books/NBK3841/">Help</a>
</li>
<li>
<a href="/books/NBK3842/">My NCBI help</a>
</li>
<li>
<a href="/books/NBK21085/">NCBI Handbook</a>
</li>
<li>
<a href="/gene/statistics/">Statistics</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-related-sites">
<div class="portlet_head">
<div class="portlet_title">
<h3>Related sites</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_RelatedSites" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://www.ncbi.nlm.nih.gov/BLAST">BLAST</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/genome">Genome</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/bioproject">BioProject</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/genome/gdv/">Genome Data Viewer</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/geo">GEO</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/omim">OMIM</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/probe">Probe</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/RefSeq">RefSeq</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-feedback">
<div class="portlet_head">
<div class="portlet_title">
<h3>Feedback</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_Feedback" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://support.ncbi.nlm.nih.gov/ics/support/ticketnewwizard.asp?style=classic&amp;deptID=28049">Contact Help Desk</a>
</li>
<li>
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<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67c9f0e8f4a390645e9e4a24">CDC37 cell division cycle 37, HSP90 cochaperone [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">CDC37 cell division cycle 37, HSP90 cochaperone [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:11140</div></div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67c9f0e6f4a390645e9e3dc5">hsp90 co-chaperone Cdc37 [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">hsp90 co-chaperone Cdc37 [Homo sapiens]<div class="brieflinkpopdesc">gi|5901922|ref|NP_008996.1|</div></div>
<div class="tertiary">Protein</div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67c9f0e4b15b832ebc6e1285">CDC20 cell division cycle 20 [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">CDC20 cell division cycle 20 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:991</div></div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67c9f0e2a68b6b5afcd0c16c">cell division cycle protein 20 homolog [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">cell division cycle protein 20 homolog [Homo sapiens]<div class="brieflinkpopdesc">gi|118402582|ref|NP_001246.2|</div></div>
<div class="tertiary">Protein</div>
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<div class="ralinkpop offscreen_noflow">T-lymphocyte activation antigen CD86 isoform 1 precursor [Homo sapiens]<div class="brieflinkpopdesc">gi|332634934|ref|NP_787058.4|</div></div>
<div class="tertiary">Protein</div>
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