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<div class="search"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="pubmed">PubMed</option><option value="clinvar">ClinVar</option><option value="medgen">MedGen</option><option value="books" class="last">Books</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly" data-ac_dict="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene" selected="selected" data-ac_dict="gene">Gene</option><option value="genome" data-ac_dict="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen">MedGen</option><option value="mesh">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore" data-ac_dict="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein" data-ac_dict="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search Gene. Use up and down arrows to choose an item from the autocomplete." value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="dictionary:'gene',disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'yes',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div><ul class="searchlinks inline_list"><set></set><li><a href="/gene/advanced">Advanced</a></li><li class="help"><a id="help" class="jig-ncbihelpwindow" target="ncbihelp" name="help" href="/books/NBK3841/">Help</a></li></ul></div>
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<div class="facet_cont" data-db="gene" data-default_grps="fg_gene-sources,fg_categories,fg_sequence-content,fg_status" data-sd="db:'gene',op:'select',term:'',qk:'2546',linkname:'',idsfromresult:'109',extra:''"><ul class="facet" data-filter_id="gene-sources" id="_gene-sources"><li class="filter_grp "><div class="clearfix"><h3>Gene sources</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="genomic">Genomic</a></li></ul></li></ul><ul class="facet" data-filter_id="categories" id="_categories"><li class="filter_grp "><div class="clearfix"><h3>Categories</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="alt-splicing">Alternatively spliced</a></li><li class="fil_val"><a href="#" data-value_id="annotated-genes">Annotated genes</a></li><li class="fil_val"><a href="#" data-value_id="gene-type-protein-coding">Protein-coding</a></li></ul></li></ul><ul class="facet" data-filter_id="sequence-content" id="_sequence-content"><li class="filter_grp "><div class="clearfix"><h3>Sequence content</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="seq-ccds">CCDS</a></li><li class="fil_val"><a href="#" data-value_id="seq-ensembl">Ensembl</a></li><li class="fil_val"><a href="#" data-value_id="refseq">RefSeq</a></li></ul></li></ul><ul class="facet" data-filter_id="status" id="_status"><li class="filter_grp "><div class="clearfix"><h3>Status</h3><a href="#" data-value_id="" class="clear clear_show">Clear</a></div><ul><li class="fil_val selected"><a href="#" data-value_id="current-only">Current</a><span class="fcount">(1)</span></li></ul></li></ul><div id="chr-location-facet-wrapper" data-bid="MCID_67c9d5f7d74f6769103dcd1d" data-hid="MCID_67c90f2d64f30b25346ccae2" data-qky="2546" class="disabled" style="display:none"><ul class="facet" data-filter_id="chromosomal-region" id="_chromosomal-region" data-of="yes"><li class="filter_grp of_grp"><div class="clearfix"><h3>Chromosome locations</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><a id="facet_ofchromosomal-region" href="#facet_of_divchromosomal-region" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'middle left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '375px'" data-value_id="fetch_more">more...</a><div id="facet_of_divchromosomal-region" style="display:none;" class="of_popup"><h4>Chromosome locations</h4><label for="organism-filter" style="width:100%;margin-bottom:.2em;" class="">Select an organism by typing or scrolling</label><input type="text" placeholder="Enter text to narrow down the list" id="organism-filter" style="width:98%;" autocomplete="off" /><br /><div id="chr-region-tax-list"><select id="of_chromosomal-region" size="9" class="chr-region-tax-list" style="width:100%;"></select></div><div id="chr-location-info-ctrl" data-disabled="disabled"><div class="chr-field"><label for="chr-name">Chromosome</label><br /><select id="chr-name" class="chr-field" disabled="disabled"></select></div><div class="chr-field"><label for="chr-from">From</label><br /><input type="text" name="chr-from" id="chr-from" disabled="disabled" class="chr-field" /></div><div class="chr-field"><label for="chr-to">To</label><br /><input type="text" name="chr-to" id="chr-to" disabled="disabled" class="chr-field" /></div></div><div class="actions clearfix"><button class="jig-ncbibutton of_add apply-chr" data-jigconfig="'color': 'ui-ncbibutton-blue'">Apply</button></div></div></ul></li></ul></div><ul class="facet facet_reset"><li><a href="#" data-value_id="reset">Clear all</a></li></ul><ul class="facet_tools"><li><a id="more_filter_groups_link" href="#more_filter_groups" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'top left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '180px'">
Show additional filters</a></li><div id="more_filter_groups" style="display:none;" class="facets_dialog"><button class="ui-ncbipopper-close-button ui-ncbipopper-close-button-generated ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-blue" generated="true" role="button" aria-disabled="false"><span class="ui-button-text">x</span></button><h4>Additional filters</h4><ul class="filter_groups_more facet"><li><input type="checkbox" id="fg_gene-sources" /><label for="fg_gene-sources">Gene sources</label></li><li><input type="checkbox" id="fg_categories" /><label for="fg_categories">Categories</label></li><li><input type="checkbox" id="fg_sequence-content" /><label for="fg_sequence-content">Sequence content</label></li><li><input type="checkbox" id="fg_status" /><label for="fg_status">Status</label></li><li><input type="checkbox" id="fg_chromosomal-region" /><label for="fg_chromosomal-region">Chromosome locations</label></li><li><input id="fg_field_search" type="checkbox" /><label for="fg_field_search">Search fields</label></li></ul><div class="actions clearfix"><button class="filter_groups_more_apply jig-ncbibutton primary-action" id="filter_groups_apply" data-jigconfig="'color': 'ui-ncbibutton-blue'">Show</button></div></div></ul><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetsUrlFrag" sid="1" type="hidden" value="filters=current-only" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetSubmitted" sid="1" type="hidden" value="false" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.BMFacets" sid="1" type="hidden" value="" /></div>
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<h1 class="title" id="gene-name"><span class="gn" style="padding-right:.5em;">ADCY3</span> adenylate cyclase 3 [ <em class="tax">Homo sapiens</em> (human)
]
</h1>
<span class="geneid">Gene ID: 109, updated on
4-Mar-2025</span>
</div>
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<div class="rprt-section gene-summary">
<section class="rprt-section-header" id="summary">
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<dl id="summaryDl">
<dt class="noline"> Official
Symbol</dt>
<dd class="noline">ADCY3<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
<dt> Official
Full Name</dt>
<dd>adenylate cyclase 3<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
<dt>Primary source</dt>
<dd>
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:234" data-gblink-text="Ensembl">HGNC:HGNC:234</a>
</dd>
<dt>See related</dt>
<dd>
<a href="http://www.ensembl.org/id/ENSG00000138031" data-gblink-text="Ensembl" class="genome-browser-link" data-genome-browser-link-sort="5" data-gb-url="http://www.ensembl.org/loc/ENSG00000138031">Ensembl:ENSG00000138031</a>
<a href="https://www.ncbi.nlm.nih.gov/omim/600291" data-gblink-text="Ensembl" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=600291">MIM:600291;</a>
<a href="https://www.alliancegenome.org/gene/HGNC:234" data-gblink-text="Ensembl" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=HGNC:234">AllianceGenome:HGNC:234</a>
</dd>
<dt>Gene type</dt>
<dd>protein coding</dd>
<dt>RefSeq status</dt>
<dd>REVIEWED</dd>
<dt>Organism</dt>
<dd class="tax">
<a href="/Taxonomy/Browser/wwwtax.cgi?id=9606" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=9606">Homo sapiens</a>
</dd>
<dt>Lineage</dt>
<dd class="tax">Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo</dd>
<dt>Also known as</dt>
<dd>AC3; AC-III; BMIQ19</dd>
<dt>Summary</dt>
<dd>This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]</dd>
<dt>Expression</dt>
<dd>Ubiquitous expression in placenta (RPKM 27.7), ovary (RPKM 14.8) and 23 other tissues <a href="#gene-expression">See more</a></dd>
<dt>Orthologs</dt>
<dd class="ortholog-links">
<a href="/gene/109/ortholog/">all</a>
</dd>
<dt style="padding-top:.5em;">
<span class="new-icon">NEW</span>
</dt>
<dd style="padding-top:.5em;">
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/109/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="gene_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Gene table</a></strong>
<br />
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/109/products/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="transcript_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Transcript table</a></strong>
</dd>
</dl>
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<div class="rprt-section gene-genomic-context">
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<div style="float:right"><span>See ADCY3 in </span><a href="/genome/gdv/?context=gene&amp;acc=109" class="link-to-gdv genome-browser-link" data-genome-browser-link-sort="1" data-acc="GCF_000001405.40">Genome Data Viewer</a> </div>
<dl class="dl-chr-info" style="float:left;margin-top:0;">
<dt>Location: </dt>
<dd>
<span style="display:inline-block;">2p23.3</span>
</dd>
</dl>
</div>
<dl class="dl-chr-info exon-count">
<dt>Exon count: </dt>
<dd>28</dd>
</dl>
<div class="ui-ncbigrid-outer-div" id="genomic-context-tbl-location">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="">
<thead>
<tr>
<th style="max-width:15%">Annotation release</th>
<th style="max-width:10%">Status</th>
<th>Assembly</th>
<th>
<span title="Chromosome">Chr</span>
</th>
<th>Location</th>
</tr>
</thead>
<tbody>
<tr>
<td>RS_2024_08</td>
<td>current</td>
<td>GRCh38.p14 (<a href="/assembly/GCF_000001405.40/" ref="ncbi_uid=109&amp;link_uid=GCF_000001405.40">GCF_000001405.40</a>)</td>
<td>2</td>
<td>NC_000002.12 (24819169..24920237, complement) </td>
</tr>
<tr>
<td>RS_2024_08</td>
<td>current</td>
<td>T2T-CHM13v2.0 (<a href="/assembly/GCF_009914755.1/" ref="ncbi_uid=109&amp;link_uid=GCF_009914755.1">GCF_009914755.1</a>)</td>
<td>2</td>
<td>NC_060926.1 (24853918..24954979, complement) </td>
</tr>
<tr>
<td>RS_2024_09</td>
<td>previous assembly</td>
<td>GRCh37.p13 (<a href="/assembly/GCF_000001405.25/" ref="ncbi_uid=109&amp;link_uid=GCF_000001405.25">GCF_000001405.25</a>)</td>
<td>2</td>
<td>NC_000002.11 (25042038..25143106, complement) </td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<p class="withnote margin_t2em"><strong>Chromosome 2 - NC_000002.12</strong><img usemap="#nbrMap109_568815596" border="0" alt="Genomic Context describing neighboring genes" src="/gutils/geneneighb.fcgi?geneid=109&amp;nuc_gi=568815596&amp;n0=NCOA1&amp;n1=RNU6-936P&amp;n2=PTRHD1&amp;n3=LOC105369164&amp;n4=LOC129933271&amp;n5=LOC129933272&amp;n6=CENPO&amp;n7=ADCY3&amp;n8=LOC127272827&amp;n9=LOC127272828&amp;n10=LOC127272829&amp;n11=LOC127272830&amp;n12=LOC105377626&amp;n13=LOC122756671&amp;n14=LOC127272831&amp;n15=LOC127272832&amp;n16=LOC127272833&amp;n17=LOC127272834&amp;n18=LOC127272835&amp;n19=LOC127272836&amp;n20=LOC129933273&amp;n21=LOC129933274&amp;n22=LOC124907742&amp;n23=LOC129933275&amp;n24=LOC129933276&amp;n25=LOC129933277&amp;n26=LOC127272837&amp;n27=LOC129933278&amp;n28=DNAJC27&amp;n29=LOC127272838&amp;n30=RPS13P5" /><map name="nbrMap109_568815596" id="nbrMap109_568815596">
<area shape="rect" onMouseOver="showtip(this,event,'nuclear receptor coactivator 1')" onMouseOut="hidetip()" coords="37,23,273,31" alt="Neighboring gene nuclear receptor coactivator 1" href="/gene/8648" />
<area shape="rect" onMouseOver="showtip(this,event,'RNA, U6 small nuclear 936, pseudogene')" onMouseOut="hidetip()" coords="155,35,210,43" alt="Neighboring gene RNA, U6 small nuclear 936, pseudogene" href="/gene/106481924" />
<area shape="rect" onMouseOver="showtip(this,event,'uncharacterized LOC105369164')" onMouseOut="hidetip()" coords="225,35,295,43" alt="Neighboring gene uncharacterized LOC105369164" href="/gene/105369164" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 11234')" onMouseOut="hidetip()" coords="226,47,296,55" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11234" href="/gene/129933271" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 15435')" onMouseOut="hidetip()" coords="227,59,297,67" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15435" href="/gene/129933272" />
<area shape="rect" onMouseOver="showtip(this,event,'OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25044835-25045378')" onMouseOut="hidetip()" coords="249,71,319,79" alt="Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25044835-25045378" href="/gene/127272827" />
<area shape="rect" onMouseOver="showtip(this,event,'NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25045379-25045923')" onMouseOut="hidetip()" coords="249,83,319,91" alt="Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25045379-25045923" href="/gene/127272828" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25048335-25048894')" onMouseOut="hidetip()" coords="252,95,322,103" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25048335-25048894" href="/gene/127272829" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25048895-25049453')" onMouseOut="hidetip()" coords="252,107,322,115" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25048895-25049453" href="/gene/127272830" />
<area shape="rect" onMouseOver="showtip(this,event,'peptidyl-tRNA hydrolase domain containing 1')" onMouseOut="hidetip()" coords="255,119,295,127" alt="Neighboring gene peptidyl-tRNA hydrolase domain containing 1" href="/gene/391356" />
<area shape="rect" onMouseOver="showtip(this,event,'uncharacterized LOC105377626')" onMouseOut="hidetip()" coords="256,131,326,139" alt="Neighboring gene uncharacterized LOC105377626" href="/gene/105377626" />
<area shape="rect" onMouseOver="showtip(this,event,'Sharpr-MPRA regulatory region 9030')" onMouseOut="hidetip()" coords="257,143,327,151" alt="Neighboring gene Sharpr-MPRA regulatory region 9030" href="/gene/122756671" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr2:25057468-25058391')" onMouseOut="hidetip()" coords="258,155,328,163" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25057468-25058391" href="/gene/127272832" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr2:25056543-25057467')" onMouseOut="hidetip()" coords="258,167,328,175" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25056543-25057467" href="/gene/127272831" />
<area shape="rect" onMouseOver="showtip(this,event,'centromere protein O')" onMouseOut="hidetip()" coords="263,179,311,187" alt="Neighboring gene centromere protein O" href="/gene/79172" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr2:25097035-25097779')" onMouseOut="hidetip()" coords="288,191,358,199" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25097035-25097779" href="/gene/127272833" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr2:25121605-25122524')" onMouseOut="hidetip()" coords="306,35,376,43" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25121605-25122524" href="/gene/127272834" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr2:25126133-25126634')" onMouseOut="hidetip()" coords="310,47,380,55" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25126133-25126634" href="/gene/127272835" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr2:25126635-25127134')" onMouseOut="hidetip()" coords="310,59,380,67" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25126635-25127134" href="/gene/127272836" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 15436')" onMouseOut="hidetip()" coords="320,71,390,79" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15436" href="/gene/129933273" />
<area shape="rect" onMouseOver="showtip(this,event,'uncharacterized LOC124907742')" onMouseOut="hidetip()" coords="322,83,392,91" alt="Neighboring gene uncharacterized LOC124907742" href="/gene/124907742" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 11237')" onMouseOut="hidetip()" coords="322,119,392,127" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11237" href="/gene/129933276" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 11236')" onMouseOut="hidetip()" coords="322,179,392,187" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11236" href="/gene/129933275" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 11235')" onMouseOut="hidetip()" coords="322,203,392,211" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11235" href="/gene/129933274" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 11238')" onMouseOut="hidetip()" coords="323,95,393,103" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11238" href="/gene/129933277" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr2:25149032-25149746')" onMouseOut="hidetip()" coords="327,107,397,115" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25149032-25149746" href="/gene/127272837" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 15437')" onMouseOut="hidetip()" coords="327,131,397,139" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15437" href="/gene/129933278" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac hESC enhancer GRCh37_chr2:25180226-25181180')" onMouseOut="hidetip()" coords="350,143,420,151" alt="Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:25180226-25181180" href="/gene/127272838" />
<area shape="rect" onMouseOver="showtip(this,event,'DnaJ heat shock protein family (Hsp40) member C27')" onMouseOut="hidetip()" coords="365,155,423,163" alt="Neighboring gene DnaJ heat shock protein family (Hsp40) member C27" href="/gene/51277" />
<area shape="rect" onMouseOver="showtip(this,event,'ribosomal protein S13 pseudogene 5')" onMouseOut="hidetip()" coords="378,35,423,43" alt="Neighboring gene ribosomal protein S13 pseudogene 5" href="/gene/100271061" />
</map>
</p>
</div>
</div>
<div class="rprt-section gene-genomic-regions-transcripts-products">
<section class="rprt-section-header" id="genomic-regions-transcripts-products">
<h2 id="header-genomic-regions-transcripts-products">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-regions-transcripts-products .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Genomic regions, transcripts, and products</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Genomic_Regions_Transcripts_a" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<div style="text-align:right;">Go to <a href="#reference-sequences">reference sequence details</a></div>
</div>
<div>
<p class="choose">
<label for="accession" class="label">Genomic Sequence: </label>
<select name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.accessionList" sid="1" id="accessionList" data-taxid="9606" data-geneid="109">
<option value="NC_000002.12_24819168_24920236">NC_000002.12 Chromosome 2 Reference GRCh38.p14 Primary Assembly</option>
<option value="NC_060926.1_24853917_24954978">NC_060926.1 Chromosome 2 Alternate T2T-CHM13v2.0</option>
<option value="NC_000002.11_25042037_25143105">NC_000002.11 Chromosome 2 Reference GRCh37.p13 Primary Assembly</option>
</select>
</p>
</div>
<div id="NC_000002" class="divAccession">
<div class="seq-viewer">
<p class="note-link">
<strong>Go to nucleotide:</strong>
<a title="Nucleotide Graphic report" href="/nuccore/NC_000002.12?report=graph&amp;from=24804008&amp;to=24935396&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=NC_000002.12">Graphics</a>
<a title="Nucleotide FASTA report" href="/nuccore/NC_000002.12?report=fasta&amp;from=24819169&amp;to=24920237&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=NC_000002.12">FASTA</a>
<a title="Nucleotide GenBank report" href="/nuccore/NC_000002.12?report=genbank&amp;from=24819169&amp;to=24920237&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=NC_000002.12">GenBank</a>
</p>
<div id="divNC_000002" class="SeqViewerApp" style="clear:both;" data-sv="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000002.12&amp;from=24804008&amp;to=24935396&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40">
<a href="?appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000002.12&amp;from=24804008&amp;to=24935396&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40"></a>
</div>
</div>
</div>
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000002.12" sid="1" type="hidden" id="nucleotideLink_NC_000002_12_24819168_24920236" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_000002.12?report=graph&amp;amp;from=24804008&amp;amp;to=24935396&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.40&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=109&amp;amp;link_uid=NC_000002.12&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_000002.12?report=fasta&amp;amp;from=24819169&amp;amp;to=24920237&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=109&amp;amp;link_uid=NC_000002.12&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_000002.12?report=genbank&amp;amp;from=24819169&amp;amp;to=24920237&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=109&amp;amp;link_uid=NC_000002.12&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000002.12" sid="1" type="hidden" id="relString_NC_000002_12_24819168_24920236" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_000002.12&amp;amp;from=24804008&amp;amp;to=24935396&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.40" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_060926.1" sid="1" type="hidden" id="nucleotideLink_NC_060926_1_24853917_24954978" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_060926.1?report=graph&amp;amp;from=24838758&amp;amp;to=24970137&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_009914755.1&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=109&amp;amp;link_uid=NC_060926.1&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_060926.1?report=fasta&amp;amp;from=24853918&amp;amp;to=24954979&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=109&amp;amp;link_uid=NC_060926.1&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_060926.1?report=genbank&amp;amp;from=24853918&amp;amp;to=24954979&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=109&amp;amp;link_uid=NC_060926.1&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_060926.1" sid="1" type="hidden" id="relString_NC_060926_1_24853917_24954978" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_060926.1&amp;amp;from=24838758&amp;amp;to=24970137&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_009914755.1" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000002.11" sid="1" type="hidden" id="nucleotideLink_NC_000002_11_25042037_25143105" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_000002.11?report=graph&amp;amp;from=25026877&amp;amp;to=25158265&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.25&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=109&amp;amp;link_uid=NC_000002.11&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_000002.11?report=fasta&amp;amp;from=25042038&amp;amp;to=25143106&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=109&amp;amp;link_uid=NC_000002.11&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_000002.11?report=genbank&amp;amp;from=25042038&amp;amp;to=25143106&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=109&amp;amp;link_uid=NC_000002.11&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000002.11" sid="1" type="hidden" id="relString_NC_000002_11_25042037_25143105" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_000002.11&amp;amp;from=25026877&amp;amp;to=25158265&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.25" />
</div>
</div>
<div class="rprt-section gene-gene-expression">
<section class="rprt-section-header" id="gene-expression">
<h2 id="header-gene-expression">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-gene-expression .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Expression</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Expression" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<div style="text-align:right;">
<a href="/gene/109/?report=expression" data-url="/gene/109/?report=expression" id="gene-expression-see-details">See details</a>
</div>
<div id="gene-expression-app" data-url="https://www.ncbi.nlm.nih.gov/gene/109" data-report-type="summary">
<div>
<script type="text/javascript">
window.tissues_data = {'adrenal 10wk': {'id': '109_Adrenal_10wk_PRJNA270632', 'gene': 109, 'source_name': 'adrenal 10wk', 'full_rpkm': 0.821683, 'exp_rpkm': 0.822, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734387532300290}, 'adrenal 16wk': {'id': '109_Adrenal_16wk_PRJNA270632', 'gene': 109, 'source_name': 'adrenal 16wk', 'full_rpkm': 1.42811, 'exp_rpkm': 1.43, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734387532300291}, 'adrenal 18wk': {'id': '109_Adrenal_18wk_PRJNA270632', 'gene': 109, 'source_name': 'adrenal 18wk', 'full_rpkm': 1.64365, 'exp_rpkm': 1.64, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734387532300292}, 'adrenal 20wk': {'id': '109_Adrenal_20wk_PRJNA270632', 'gene': 109, 'source_name': 'adrenal 20wk', 'full_rpkm': 1.309, 'exp_rpkm': 1.31, 'var': 0.00489126, 'project_desc': 'PRJNA270632', '_version_': 1785734387532300293}, 'heart 10wk': {'id': '109_Heart_10wk;_PRJNA270632', 'gene': 109, 'source_name': 'heart 10wk', 'full_rpkm': 1.66223, 'exp_rpkm': 1.66, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734387532300294}, 'heart 11wk': {'id': '109_Heart_11wk;_PRJNA270632', 'gene': 109, 'source_name': 'heart 11wk', 'full_rpkm': 1.66819, 'exp_rpkm': 1.67, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734387532300295}, 'heart 17wk': {'id': '109_Heart_17wk;_PRJNA270632', 'gene': 109, 'source_name': 'heart 17wk', 'full_rpkm': 0.868283, 'exp_rpkm': 0.868, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734387532300296}, 'heart 18wk': {'id': '109_Heart_18wk;_PRJNA270632', 'gene': 109, 'source_name': 'heart 18wk', 'full_rpkm': 1.31899, 'exp_rpkm': 1.32, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734387532300297}, 'heart 20wk': {'id': '109_Heart_20wk_PRJNA270632', 'gene': 109, 'source_name': 'heart 20wk', 'full_rpkm': 0.359383, 'exp_rpkm': 0.359, 'var': 0.01131804, 'project_desc': 'PRJNA270632', '_version_': 1785734387532300298}, 'intestine 10wk': {'id': '109_Intestine_10wk_PRJNA270632', 'gene': 109, 'source_name': 'intestine 10wk', 'full_rpkm': 0.58509, 'exp_rpkm': 0.585, 'var': 0.00427128, 'project_desc': 'PRJNA270632', '_version_': 1785734387532300299}, 'intestine 11wk': {'id': '109_Intestine_11wk_PRJNA270632', 'gene': 109, 'source_name': 'intestine 11wk', 'full_rpkm': 1.51836, 'exp_rpkm': 1.52, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734387532300300}, 'intestine 15wk': {'id': '109_Intestine_15wk_PRJNA270632', 'gene': 109, 'source_name': 'intestine 15wk', 'full_rpkm': 1.479, 'exp_rpkm': 1.48, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734387532300301}, 'intestine 17wk': {'id': '109_Intestine_17wk_PRJNA270632', 'gene': 109, 'source_name': 'intestine 17wk', 'full_rpkm': 1.33146, 'exp_rpkm': 1.33, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734387532300302}, 'intestine 20wk': {'id': '109_Intestine_20wk_PRJNA270632', 'gene': 109, 'source_name': 'intestine 20wk', 'full_rpkm': 1.46143, 'exp_rpkm': 1.46, 'var': 0.01601922, 'project_desc': 'PRJNA270632', '_version_': 1785734387532300303}, 'kidney 10wk': {'id': '109_Kidney_10wk_PRJNA270632', 'gene': 109, 'source_name': 'kidney 10wk', 'full_rpkm': 1.35116, 'exp_rpkm': 1.35, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734387532300304}, 'kidney 16wk': {'id': '109_Kidney_16wk_PRJNA270632', 'gene': 109, 'source_name': 'kidney 16wk', 'full_rpkm': 0.867734, 'exp_rpkm': 0.868, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734387532300305}, 'kidney 20wk': {'id': '109_Kidney_20wk_PRJNA270632', 'gene': 109, 'source_name': 'kidney 20wk', 'full_rpkm': 0.262843, 'exp_rpkm': 0.263, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734387532300306}, 'lung 10wk': {'id': '109_Lung_10wk_PRJNA270632', 'gene': 109, 'source_name': 'lung 10wk', 'full_rpkm': 2.63158, 'exp_rpkm': 2.63, 'var': 0.00293332, 'project_desc': 'PRJNA270632', '_version_': 1785734387532300307}, 'lung 17wk': {'id': '109_Lung_17wk_PRJNA270632', 'gene': 109, 'source_name': 'lung 17wk', 'full_rpkm': 2.45796, 'exp_rpkm': 2.46, 'var': 0.0486756, 'project_desc': 'PRJNA270632', '_version_': 1785734387532300308}, 'lung 20wk': {'id': '109_Lung_20wk_PRJNA270632', 'gene': 109, 'source_name': 'lung 20wk', 'full_rpkm': 1.85853, 'exp_rpkm': 1.86, 'var': 0.00990688, 'project_desc': 'PRJNA270632', '_version_': 1785734387532300309}, 'stomach 10wk': {'id': '109_Stomach_10wk_PRJNA270632', 'gene': 109, 'source_name': 'stomach 10wk', 'full_rpkm': 1.73199, 'exp_rpkm': 1.73, 'var': 0.0912362, 'project_desc': 'PRJNA270632', '_version_': 1785734387532300310}, 'stomach 16wk': {'id': '109_Stomach_16wk_PRJNA270632', 'gene': 109, 'source_name': 'stomach 16wk', 'full_rpkm': 2.4908, 'exp_rpkm': 2.49, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734387532300311}, 'stomach 18wk': {'id': '109_Stomach_18wk_PRJNA270632', 'gene': 109, 'source_name': 'stomach 18wk', 'full_rpkm': 2.85353, 'exp_rpkm': 2.85, 'var': 0.0, 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<select name="p" id="project-selector">
<option value="SRP051249" selected="selected" data-bioproject="PRJNA270632">
Tissue-specific circular RNA induction during human fetal development
</option>
<option value="SRP056969" data-bioproject="PRJNA280600">
RNA sequencing of total RNA from 20 human tissues
</option>
<option value="ERP003613" data-bioproject="PRJEB4337">
HPA RNA-seq normal tissues
</option>
</select>
<ul id="project-summary">
<li id="project-summary-title">Project title:
Tissue-specific circular RNA induction during human fetal development
</li>
<li id="project-summary-desc">Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA</li>
<li id="project-summary-bioprojects">BioProject: <a href="/bioproject/PRJNA270632/">PRJNA270632</a>
</li>
<li id="project-summary-pubs">Publication:
<span><a href="/pubmed/26076956/">PMID 26076956</a></span>
</li>
<li id="project-summary-analysis-date">Analysis date: Mon Apr 2 22:54:59 2018</li>
</ul>
<div id="gene-expr-details" class="expression-chart"></div>
</div>
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<section class="rprt-section-header" id="bibliography"><h2 id="header-bibliography"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-bibliography .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Bibliography</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Bibliography" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
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<div class="generif-pubmed">
<h3 id="relatedarticlesinpubmed">
<a href="#" class="jig-ncbitoggler-open">Related articles in PubMed</a>
</h3>
<div class="generefbl-link">
<ol class="generef-link">
<li>
<a href="/pubmed/17895882/" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=17895882">Genetic variation of the adenylyl cyclase 3 (AC3) locus and its influence on type 2 diabetes and obesity susceptibility in Swedish men.</a>
<span class="pubmed-auth-date"> Nordman S, <em>et al</em>. Int J Obes (Lond), 2008 Mar. PMID 17895882</span>
</li>
<li>
<a href="/pubmed/9920776/" ref="ordinalpos=2&amp;ncbi_uid=109&amp;link_uid=9920776">Molecular cloning of a full-length cDNA for human type 3 adenylyl cyclase and its expression in human islets.</a>
<span class="pubmed-auth-date"> Yang B, <em>et al</em>. Biochem Biophys Res Commun, 1999 Jan 27. PMID 9920776</span>
</li>
<li>
<a href="/pubmed/29311636/" ref="ordinalpos=3&amp;ncbi_uid=109&amp;link_uid=29311636">Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes.</a>
<span class="pubmed-auth-date"> Grarup N, <em>et al</em>. Nat Genet, 2018 Feb. PMID 29311636, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC5828106/" ref="ordinalpos=0&amp;ncbi_uid=109&amp;link_uid=PMC5828106">Free PMC Article</a></span></span>
</li>
<li>
<a href="/pubmed/29311637/" ref="ordinalpos=4&amp;ncbi_uid=109&amp;link_uid=29311637">Loss-of-function mutations in ADCY3 cause monogenic severe obesity.</a>
<span class="pubmed-auth-date"> Saeed S, <em>et al</em>. Nat Genet, 2018 Feb. PMID 29311637</span>
</li>
<li>
<a href="/pubmed/29921800/" ref="ordinalpos=5&amp;ncbi_uid=109&amp;link_uid=29921800">Interaction between an ADCY3 Genetic Variant and Two Weight-Lowering Diets Affecting Body Fatness and Body Composition Outcomes Depending on Macronutrient Distribution: A Randomized Trial.</a>
<span class="pubmed-auth-date"> Goni L, <em>et al</em>. Nutrients, 2018 Jun 19. PMID 29921800, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC6024801/" ref="ordinalpos=0&amp;ncbi_uid=109&amp;link_uid=PMC6024801">Free PMC Article</a></span></span>
</li>
</ol>
<p class="see-all-pm">
<a href="/pubmed?LinkName=gene_pubmed&amp;from_uid=109" title="See all 76 citations in Pubmed">See all (76) citations in PubMed</a>
</p>
</div>
</div>
<div class="generif-pubmed generif">
<h3 id="generifsgenereferencesintofunctions">
<a href="#" class="jig-ncbitoggler-open">GeneRIFs: Gene References Into Functions</a>
</h3>
<div>
<a href="/gene/about-generif" class="whatisthis">What's a GeneRIF?</a>
<div class="generefbl-link">
<ol class="generef-link">
<li class="gene-rif-popper">
<a href="/pubmed/38684889" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=38684889">Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function.</a>
<div id="gene-popper1" class="gene-rif-popper">Title: Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/38334651" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=38334651">Postnatal Dynamic Ciliary ARL13B and ADCY3 Localization in the Mouse Brain.</a>
<div id="gene-popper2" class="gene-rif-popper">Title: Postnatal Dynamic Ciliary ARL13B and ADCY3 Localization in the Mouse Brain.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/37955134" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=37955134">Adenylate cyclase 3: a potential genetic link between obesity and major depressive disorder.</a>
<div id="gene-popper3" class="gene-rif-popper">Title: Adenylate cyclase 3: a potential genetic link between obesity and major depressive disorder.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/34821371" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=34821371">Molecular modelling of novel ADCY3 variant predicts a molecular target for tackling obesity.</a>
<div id="gene-popper4" class="gene-rif-popper">Title: Molecular modelling of novel ADCY3 variant predicts a molecular target for tackling obesity.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/34481002" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=34481002">ALDH2, ADCY3 and BCMO1 polymorphisms and lifestyle-induced traits are jointly associated with CAD risk in Chinese Han people.</a>
<div id="gene-popper5" class="gene-rif-popper">Title: ALDH2, ADCY3 and BCMO1 polymorphisms and lifestyle-induced traits are jointly associated with CAD risk in Chinese Han people.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/29311637" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=29311637">ADCY3 is an important mediator of energy homeostasis and an attractive pharmacological target in the treatment of obesity.</a>
<div id="gene-popper6" class="gene-rif-popper">Title: Loss-of-function mutations in ADCY3 cause monogenic severe obesity.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/29311636" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=29311636">An enrichment of rare ADCY3 loss-of-function variants among individuals with type 2 diabetes in trans-ancestry cohorts.</a>
<div id="gene-popper7" class="gene-rif-popper">Title: Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/29311635" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=29311635">MC4R colocalizes with ADCY3 at the primary cilia of a subset of hypothalamic neurons; obesity-associated MC4R mutations impair ciliary localization and inhibition of adenylyl cyclase signaling at the primary cilia of these neurons increases body weight.</a>
<div id="gene-popper8" class="gene-rif-popper">Title: Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/29921800" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=29921800">This study showed that subjects carrying the G allele of the rs10182181 polymorphism may benefit more in terms of weight loss and improvement of body composition measurements when undertaking a hypocaloric low-fat diet as compared to a moderately-high-protein diet.</a>
<div id="gene-popper9" class="gene-rif-popper">Title: Interaction between an ADCY3 Genetic Variant and Two Weight-Lowering Diets Affecting Body Fatness and Body Composition Outcomes Depending on Macronutrient Distribution: A Randomized Trial.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/28122017" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=28122017">In peripheral organs, AC3 is present mainly in primary cilia in cells of the mesenchymal lineage. In epithelia, the apical cilium of renal and pancreatic tubules and of ductal plate in liver is AC3-negative whereas the cilium of basal cells of stratified epithelia is AC3-positive. Using fibroblasts cell culture, we show that AC3 appears at the plasma membrane of the primary cilium as soon as this organelle develops.</a>
<div id="gene-popper10" class="gene-rif-popper">Title: Adenylate Cyclase Type III Is Not a Ubiquitous Marker for All Primary Cilia during Development.</div>
</li>
</ol>
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<div class="submit-genrif">
<span>Submit:</span>
<a href="/gene/submit-generif/?geneId=109&amp;sym=ADCY3&amp;name=adenylate cyclase 3&amp;org=Homo sapiens">New GeneRIF</a>
<a href="/RefSeq/update.cgi?geneid=109&amp;symbol=ADCY3;task=fixpub">Correction</a>
<a href="https://www.ncbi.nlm.nih.gov/gene?db=gene&amp;report=generif&amp;term=109" class="seeall-generif">See all GeneRIFs (26)</a>
</div>
</div>
</div>
</div>
</div>
<div class="rprt-section gene-phenotypes">
<section class="rprt-section-header" id="phenotypes">
<h2 id="header-phenotypes">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-phenotypes .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Phenotypes</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Phenotype" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body info-phenotype">
<p class="nochild-link">
<a href="/gtr/tests/?term=ADCY3[gene]">Find tests for this gene in the NIH Genetic Testing Registry (GTR)</a>
</p>
<p class="nochild-link">
<a href="/gap/PheGenI?tab=1&amp;gene=109">Review eQTL and phenotype association data in this region using PheGenI</a>
</p>
<div>
<h3 id="associatedconditions">Associated conditions</h3>
<table class="jig-ncbigrid gtr-associated-cond">
<thead>
<tr>
<th class="description">Description</th>
<th>Tests</th>
</tr>
</thead>
<tbody>
<tr>
<td>
<a href="/gtr/conditions/C4693522" ref="ncbi_uid=109&amp;link_uid=C4693522">BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 19</a>
<div class="gtr-associated-cond-extra">
<span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C4693522" ref="ncbi_uid=109&amp;link_uid=C4693522">C4693522</a></span>
<span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/617885" ref="ncbi_uid=109"> 617885</a></span>
<span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span>
</div>
</td>
<td>
<a href="/gtr/tests/?term=C4693522[DISCUI]&amp;condition=C4693522&amp;compare_labs=1" ref="ncbi_uid=109">Compare labs</a>
</td>
</tr>
</tbody>
</table>
</div>
<div>
<h3 id="ebigwascatalog">EBI GWAS Catalog</h3>
<table class="jig-ncbigrid gtr-associated-cond" data-jigconfig="isPageable: true, pageSize: 10">
<thead>
<tr>
<th class="description">Description</th>
</tr>
</thead>
<tbody>
<tr>
<td>A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/21980299">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/21980299">PubMed</a></span></div></div></div></td>
</tr>
<tr>
<td>A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/23583978">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/23583978">PubMed</a></span></div></div></div></td>
</tr>
<tr>
<td>Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/20935630">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/20935630">PubMed</a></span></div></div></div></td>
</tr>
<tr>
<td>Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/23449627">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/23449627">PubMed</a></span></div></div></div></td>
</tr>
<tr>
<td>Genome-wide association study of body mass index in 23 000 individuals with and without asthma.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/23517042">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/23517042">PubMed</a></span></div></div></div></td>
</tr>
<tr>
<td>Genome-wide association study of height-adjusted BMI in childhood identifies functional variant in ADCY3.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/25044758">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/25044758">PubMed</a></span></div></div></div></td>
</tr>
<tr>
<td>Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/23563607">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/23563607">PubMed</a></span></div></div></div></td>
</tr>
<tr>
<td>Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/23128233">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/23128233">PubMed</a></span></div></div></div></td>
</tr>
<tr>
<td>Many sequence variants affecting diversity of adult human height.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/18391951">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/18391951">PubMed</a></span></div></div></div></td>
</tr>
<tr>
<td>Meta-analysis identifies common variants associated with body mass index in east Asians.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/22344219">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/22344219">PubMed</a></span></div></div></div></td>
</tr>
<tr>
<td>Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/24861553">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/24861553">PubMed</a></span></div></div></div></td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<div class="rprt-section gene-variation">
<section class="rprt-section-header" id="variation">
<h2 id="header-variation">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-variation .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Variation</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.variation" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<p class="nochild-link">
<a href="/clinvar/?term=ADCY3[gene]" ref="log$=recordlinks">See variants in ClinVar</a>
</p>
<p class="nochild-link">
<a href="/dbvar?LinkName=gene_dbvar&amp;from_uid=109" ref="log$=recordlinks">See studies and variants in dbVar</a>
</p>
<p class="nochild-link">
<a href="/variation/view/?q=109[geneid]&amp;assm=GCF_000001405.25" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh37.p13)">See Variation Viewer (GRCh37.p13)</a>
</p>
<p class="nochild-link">
<a href="/variation/view/?q=109[geneid]" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh38)">See Variation Viewer (GRCh38)</a>
</p>
<set></set>
<set></set>
</div>
</div>
<div class="rprt-section gene-HIV-1-interactions">
<section class="rprt-section-header" id="HIV-1-interactions">
<h2 id="header-HIV-1-interactions">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-HIV-1-interactions .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">HIV-1 interactions</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.HIV1_interactions" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div class="fgrid">
<h3 id="proteininteractions">Protein interactions</h3>
<table summary="protein interactions" class="jig-ncbigrid">
<thead>
<tr>
<th id="hivprotein">Protein</th>
<th id="gene-hivprotein">Gene</th>
<th id="hivinter">Interaction</th>
<th id="hivpub">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="hivprotein">
<a href="/protein/28876544">Envelope surface glycoprotein gp120</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">The addition of HIV-1 gp120 with TNF-alpha to human B-cells stimulates cAMP production in a dose-dependent manner</td>
<td headers="hivpub">
<a title="PubMed Id(s): 10808179" href="/pubmed/10808179">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/19172954">Envelope transmembrane glycoprotein gp41</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">Secretion of IL-10 is upregulated by HIV-1 gp41 in monocytes through activation of cAMP/adenylate cyclase and p70 (S6)-kinase; up-regulation of IL-10 is paralleled by an enhanced expression of the chemokine receptor CCR5</td>
<td headers="hivpub">
<a title="PubMed Id(s): 10807185,10089566" href="/pubmed/10807185,10089566">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/28872818">Nef</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/156110">nef</a>
</td>
<td headers="hivinter">HIV-1 induces the upregulation of complement factor C3 in astrocytes and neurons through signaling pathways that involve protein kinase C and adenylate cyclase activation, which is an effect that may contribute to the pathogenesis of AIDS in the brain</td>
<td headers="hivpub">
<a title="PubMed Id(s): 11884542" href="/pubmed/11884542">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/9629358">Tat</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">HIV-1 Tat inhibits adenylyl cyclase activity in microglia and astrocyte cultures from neonatal rat brain, suggesting that Tat inhibition of cAMP synthesis may contribute to neuronal degeneration and cell death associated with HIV infection</td>
<td headers="hivpub">
<a title="PubMed Id(s): 11299302" href="/pubmed/11299302">PubMed</a>
</td>
</tr>
</tbody>
</table>
<p class="withnote">
<a class="note" href="/genome/viruses/retroviruses/hiv-1/interactions/">Go to the HIV-1, Human Interaction Database </a>
</p>
</div>
</div>
</div>
<div class="rprt-section gene-pathways">
<section class="rprt-section-header" id="pathways">
<h2 id="header-pathways">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-pathways .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Pathways from PubChem</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<ul class="geneinfo-subsec infopathway">
<iframe title="Pathways in which the gene target is involved" class="pubchem-widget" scrolling="no" src="https://pubchem.ncbi.nlm.nih.gov/gene/109#section=Pathways&amp;embed=true&amp;hide_all_headings=true&amp;page_size=25" style="border: 0; width: 100%;"></iframe>
<script type="text/javascript" src="https://pubchem.ncbi.nlm.nih.gov/pcfe/libs/iframeResizer.min.js"></script>
<script type="text/javascript">iFrameResize({log: false, checkOrigin: false}, '.pubchem-widget')</script>
</ul>
</div>
</div>
<div class="rprt-section gene-interactions">
<section class="rprt-section-header" id="interactions">
<h2 id="header-interactions">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-interactions .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Interactions</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Interactions" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<table summary="Gene Interaction" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/109/data/interaction/',webserviceParams: 'p$l=Ajax&amp;p$debugoutput=off', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
<thead>
<tr>
<th id="inter-prod">Products</th>
<th id="inter-interactant">Interactant</th>
<th id="inter-otherGene">Other Gene</th>
<th id="inter-compl">Complex</th>
<th id="inter-source">Source</th>
<th id="inter-pubs">Pubs</th>
<th id="inter-desc">Description</th>
</tr>
</thead>
<tbody></tbody>
</table>
</div>
</div>
<div class="rprt-section gene-general-gene-info">
<section class="rprt-section-header" id="general-gene-info">
<h2 id="header-general-gene-info">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-gene-info .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">General gene information</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.General_Gene_Information" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body" style="">
<div id="gene-markers">
<h3 id="markers">
<a class="jig-ncbitoggler">Markers</a>
</h3>
<div>
<ul class="marker odd">
<li class="marker">WI-11275 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=43780%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=43780">UniSTS:43780</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">RH80427 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=91217%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=91217">UniSTS:91217</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">ADCY3_2051 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=280433%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=280433">UniSTS:280433</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">RH36332 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=16523%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=16523">UniSTS:16523</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">UniSTS:496038 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=496038%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=496038">UniSTS:496038</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">Adcy3 (e-PCR), detects polymorphism<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=496038%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=496038">UniSTS:496038</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">D5S2617 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=2730%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=2730">UniSTS:2730</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">SHGC-150739 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=173498%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=173498">UniSTS:173498</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">G32338 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=116930%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=116930">UniSTS:116930</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">D17S757 (e-PCR), detects polymorphism<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=147150%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=147150">UniSTS:147150</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">A006F11 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=74459%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=74459">UniSTS:74459</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">ADCY3_1034 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=276974%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=276974">UniSTS:276974</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">ADCY3_V295 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=276974%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=276974">UniSTS:276974</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">D2S2168 (e-PCR), detects polymorphism<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=66557%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=66557">UniSTS:66557</a></li></ul></li>
</ul>
</div>
</div>
<div></div>
<div class="infosec">
<h3 id="homology">
<a class="jig-ncbitoggler-open">Homology</a>
</h3>
<ul class="geneinfo-subsec">
<li>
<a href="/gene/109/ortholog/" id="ncbi-ortholog-link">NCBI Orthologs</a>
</li>
<a href="https://www.orthodb.org/?ncbi=109" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8178" target="_blank">
Orthologs from OrthoDB
</a>
</ul>
</div>
<!--<component id="Gene_InfoPathway"/>-->
<div class="infosec info-comment" id="info-comment">
<h3 id="CloneNames">
<a class="jig-ncbitoggler-open">Clone Names</a>
</h3>
<ul class="geneinfo-subsec">
<li>KIAA0511 </li>
</ul>
</div>
<div class="gene-ontology infosec">
<h3 id="gene-ontology">
<a class="jig-ncbitoggler-open">
<span>Gene Ontology</span>
</a>
<a target="_blank" href="http://www.ebi.ac.uk/GOA" class="g-ontology-src" title="Provided by GOA">Provided by GOA</a>
</h3>
<div class="ontology-tables">
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Function</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005524">enables ATP binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-1-0" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0004016">enables adenylate cyclase activity</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-2-0" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0004016">enables adenylate cyclase activity</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-3-0" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005516">enables calmodulin binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-4-0" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0046872">enables metal ion binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-5-0" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
</tbody>
</table>
</div>
</div>
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Process</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0007340">involved_in acrosome reaction</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-1-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0007189">involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-2-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0007189">involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-3-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0006171">involved_in cAMP biosynthetic process</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-4-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0006171">involved_in cAMP biosynthetic process</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-5-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:1904322">involved_in cellular response to forskolin</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-6-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0030317">involved_in flagellated sperm motility</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-7-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0035556">involved_in intracellular signal transduction</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-8-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0008355">involved_in olfactory learning</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-9-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0007608">involved_in sensory perception of smell</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-10-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0007165">involved_in signal transduction</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-11-1" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/9920776" target="_blank" title="PubMed ID 9920776" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=9920776">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0007338">involved_in single fertilization</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-12-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-12-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
</tbody>
</table>
</div>
</div>
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-config="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Component</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005794">located_in Golgi apparatus</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-1-2" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0060170">located_in ciliary membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-2-2" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005929">located_in cilium</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-3-2" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005737">located_in cytoplasm</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-4-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/11549699" target="_blank" title="PubMed ID 11549699" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=11549699">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0016020">located_in membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> HDA</a>
<div id="evidence-code-5-2" class="ecode">
<br />
<a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a>
</div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/19946888" target="_blank" title="PubMed ID 19946888" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=19946888">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0016020">located_in membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-6-2" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005886">is_active_in plasma membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-7-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005886">located_in plasma membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-8-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/11549699" target="_blank" title="PubMed ID 11549699" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=11549699">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005886">is_active_in plasma membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-9-2" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005886">located_in plasma membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-10-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
</div>
</div>
</div>
<div class="rprt-section gene-general-protein-info">
<section class="rprt-section-header" id="general-protein-info">
<h2 id="header-general-protein-info">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-protein-info .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">General protein information</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.General_Protein_Information" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<dl>
<dt>Preferred Names</dt>
<dd>adenylate cyclase type 3</dd>
</dl>
<dl>
<dt>Names</dt>
<dd>ATP pyrophosphate-lyase 3</dd>
<dd>adenylate cyclase type III</dd>
<dd>adenylate cyclase, olfactive type</dd>
<dd>adenylyl cyclase 3</dd>
<dd>adenylyl cyclase, type III</dd>
</dl>
<dl>
<dt class="heading">NP_001307542.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">NP_001364057.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">NP_001364058.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">NP_001364059.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">NP_001364060.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">NP_001364061.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">NP_004027.2</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_006711988.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_011530791.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_011530792.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_011530793.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_011530794.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_011530795.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_011530796.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_016858676.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_016858677.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_016858678.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_016858680.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_047298961.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_047298962.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_047298963.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_047298964.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_047298965.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_047298966.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_047298967.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_047298968.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_047298969.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_047298970.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_047298971.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_047298972.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054196202.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054196203.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054196204.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054196205.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054196206.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054196207.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054196208.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054196209.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054196210.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054196211.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054196212.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054196213.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054196214.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054196215.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054196216.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054196217.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054196218.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054196219.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054196220.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054196221.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054196222.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054196223.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054196224.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/4.6.1.1">4.6.1.1</a></li>
</ul>
</dd>
</dl>
</div>
</div>
<div class="rprt-section gene-reference-sequences">
<section class="rprt-section-header" id="reference-sequences">
<h2 id="header-reference-sequences">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-reference-sequences .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">NCBI Reference Sequences (RefSeq)</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.NCBI_Reference_Sequences_RefS" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<p>
<span class="new-icon">NEW</span>
<strong>Try the new <a href="/datasets/tables/genes/?table_type=transcripts&amp;ids=109&amp;utm_source=gene&amp;utm_medium=referral&amp;utm_campaign=refseq" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report." data-ga-category="refseq" data-ga-action="click_datasets_link" data-ga-label="transcript_table">Transcript table</a></strong>
</p>
<h3 class="genomerefseqs gene_std_toggler" id="refseqset-independent">
<a class="jig-ncbitoggler-open">RefSeqs maintained independently of Annotated
Genomes</a>
</h3>
<div class="genomerefseqs_slave">
<p class="desc"> These reference sequences exist independently of genome builds. <a href="#refseq-expl" id="expl-refseg">Explain</a></p>
<p id="refseq-expl"> These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in <a href="#geneGenomic regions, transcripts, and products">Genomic regions,
transcripts, and products</a> above. </p>
<h4 id="mrnaandproteins-p68629584">mRNA and Protein(s) </h4>
<ol>
<li>
<p><a href="/nuccore/NM_001320613.2">NM_001320613.2</a><a href="/protein/NP_001307542.1">NP_001307542.1</a>  adenylate cyclase type 3 isoform 1</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Description</dt>
<dd>Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).</dd>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AC012073, BC020148, BC126235, BC144119, BM148122, HY136273">AC012073, BC020148, BC126235, BC144119, BM148122, HY136273</a>
</dd>
<dt>Consensus CDS</dt>
<dd>
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&amp;GO=MainBrowse&amp;DATA=CCDS82424.1">CCDS82424.1</a>
</dd>
<dt>UniProtKB/TrEMBL</dt>
<dd><a href="https://www.uniprot.org/uniprot/A0A0A0MSC1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">A0A0A0MSC1</a>, <a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a></dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000384484.2" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">ENSP00000384484.2</a>, <a href="http://www.ensembl.org/id/ENST00000405392.6" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">ENST00000405392.6</a></dd>
<dt class="clear"> Conserved Domains (3) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001307542.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=214485">smart00044</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">884</span><span class="cddto">1102</span></dt>
<dd class="clearfix"> CYCc; Adenylyl- / guanylyl cyclase, catalytic domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=278633">pfam00211</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">915</span><span class="cddto">1122</span></dt>
<dd class="clearfix"> Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=292831">pfam16214</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">44</span><span class="cddto">303</span></dt>
<dd class="clearfix"> AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/NM_001377128.1">NM_001377128.1</a><a href="/protein/NP_001364057.1">NP_001364057.1</a>  adenylate cyclase type 3 isoform 3</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AC012073">AC012073</a>
</dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a>
</dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001364057.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=306677">pfam00211</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">936</span><span class="cddto">1143</span></dt>
<dd class="clearfix"> Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=318454">pfam16214</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">44</span><span class="cddto">303</span></dt>
<dd class="clearfix"> AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/NM_001377129.1">NM_001377129.1</a><a href="/protein/NP_001364058.1">NP_001364058.1</a>  adenylate cyclase type 3 isoform 4</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AC012073">AC012073</a>
</dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B3KNM3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B3KNM3</a>
</dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001364058.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=306677">pfam00211</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">868</span><span class="cddto">1075</span></dt>
<dd class="clearfix"> Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=318454">pfam16214</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">44</span><span class="cddto">303</span></dt>
<dd class="clearfix"> AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/NM_001377130.1">NM_001377130.1</a><a href="/protein/NP_001364059.1">NP_001364059.1</a>  adenylate cyclase type 3 isoform 5</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AC012073">AC012073</a>
</dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B3KNM3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B3KNM3</a>
</dd>
<dt class="clear"> Conserved Domains (3) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001364059.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=306677">pfam00211</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">310</span><span class="cddto">494</span></dt>
<dd class="clearfix"> Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=318454">pfam16214</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">44</span><span class="cddto">303</span></dt>
<dd class="clearfix"> AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=416391">cl11967</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">757</span><span class="cddto">900</span></dt>
<dd class="clearfix"> Nucleotidyl_cyc_III; Class III nucleotidyl cyclases</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/NM_001377131.1">NM_001377131.1</a><a href="/protein/NP_001364060.1">NP_001364060.1</a>  adenylate cyclase type 3 isoform 6</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AC012073">AC012073</a>
</dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/U3KQ91" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">U3KQ91</a>
</dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000475652.1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">ENSP00000475652.1</a>, <a href="http://www.ensembl.org/id/ENST00000606682.5" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">ENST00000606682.5</a></dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001364060.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=306677">pfam00211</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">673</span><span class="cddto">880</span></dt>
<dd class="clearfix"> Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=318454">pfam16214</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2</span><span class="cddto">62</span></dt>
<dd class="clearfix"> AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/NM_001377132.1">NM_001377132.1</a><a href="/protein/NP_001364061.1">NP_001364061.1</a>  adenylate cyclase type 3 isoform 2</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AC012073">AC012073</a>
</dd>
<dt>Consensus CDS</dt>
<dd>
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&amp;GO=MainBrowse&amp;DATA=CCDS1715.1">CCDS1715.1</a>
</dd>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B3KT86" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B3KT86</a>, <a href="https://www.uniprot.org/uniprot/O60266" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">O60266</a>, <a href="https://www.uniprot.org/uniprot/Q53T54" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">Q53T54</a>, <a href="https://www.uniprot.org/uniprot/Q9UDB1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">Q9UDB1</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a>
</dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000260600.5" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">ENSP00000260600.5</a>, <a href="http://www.ensembl.org/id/ENST00000260600.9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">ENST00000260600.9</a></dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001364061.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=306677">pfam00211</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">914</span><span class="cddto">1121</span></dt>
<dd class="clearfix"> Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=318454">pfam16214</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">44</span><span class="cddto">303</span></dt>
<dd class="clearfix"> AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/NM_004036.5">NM_004036.5</a><a href="/protein/NP_004027.2">NP_004027.2</a>  adenylate cyclase type 3 isoform 2</p>
<p>
<a href="/ipg/NP_004027.2/" ref="ncbi_uid=109">See identical proteins and their annotated locations for NP_004027.2</a>
</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Description</dt>
<dd>Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.</dd>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AC012073, BC020148, BC126235, BM148122, HY136273">AC012073, BC020148, BC126235, BM148122, HY136273</a>
</dd>
<dt>Consensus CDS</dt>
<dd>
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&amp;GO=MainBrowse&amp;DATA=CCDS1715.1">CCDS1715.1</a>
</dd>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B3KT86" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B3KT86</a>, <a href="https://www.uniprot.org/uniprot/O60266" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">O60266</a>, <a href="https://www.uniprot.org/uniprot/Q53T54" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">Q53T54</a>, <a href="https://www.uniprot.org/uniprot/Q9UDB1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">Q9UDB1</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a>
</dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000505261.1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">ENSP00000505261.1</a>, <a href="http://www.ensembl.org/id/ENST00000679454.1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">ENST00000679454.1</a></dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_004027.2">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=306677">pfam00211</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">914</span><span class="cddto">1121</span></dt>
<dd class="clearfix"> Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=318454">pfam16214</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">44</span><span class="cddto">303</span></dt>
<dd class="clearfix"> AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region</dd>
</dl>
</dd>
</dl>
</li>
</ol>
</div>
<h3 class="genomerefseqs gene_std_toggler" id="annotatedrefseq-title">
<a class="jig-ncbitoggler-open">RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08</a>
</h3>
<div class="genomerefseqs_slave">
<p class="desc"> The following sections contain reference sequences that belong to a
specific genome build. <a href="#" id="expl-genomes">Explain</a></p>
<p id="expl-genomes-desc" style="display:none">This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.</p>
<h3 id="refseq-sequencedescription-p139715696">Reference GRCh38.p14 Primary Assembly</h3>
<h4 id="genomic-p139715696">Genomic </h4>
<ol>
<li>
<p>NC_000002.12 Reference GRCh38.p14 Primary Assembly</p>
<dl>
<dt>Range</dt>
<dd class="rs-range">
<span>24819169..24920237 complement</span>
</dd>
<dt>Download</dt>
<dd><a href="/nuccore/NC_000002.12?from=24819169&amp;to=24920237&amp;report=genbank&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=NC_000002.12?from=24819169&amp;to=24920237&amp;report=genbank&amp;strand=true">GenBank</a>, <a href="/nuccore/NC_000002.12?from=24819169&amp;to=24920237&amp;report=fasta&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=NC_000002.12?from=24819169&amp;to=24920237&amp;report=fasta&amp;strand=true">FASTA</a>, <a href="/nuccore/NC_000002.12?from=24804008&amp;to=24935396&amp;report=graph&amp;content=5&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=NC_000002.12?from=24804008&amp;to=24935396&amp;report=graph&amp;content=5&amp;strand=true">Sequence Viewer (Graphics)</a></dd>
</dl>
</li>
</ol>
<h4 id="mrnaandproteins-p122873328">mRNA and Protein(s) </h4>
<ol>
<li>
<p><a href="/nuccore/XM_047443014.1">XM_047443014.1</a><a href="/protein/XP_047298970.1">XP_047298970.1</a>  adenylate cyclase type 3 isoform X20</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B3KNM3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B3KNM3</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047443012.1">XM_047443012.1</a><a href="/protein/XP_047298968.1">XP_047298968.1</a>  adenylate cyclase type 3 isoform X18</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B3KNM3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B3KNM3</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047443009.1">XM_047443009.1</a><a href="/protein/XP_047298965.1">XP_047298965.1</a>  adenylate cyclase type 3 isoform X15</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047443010.1">XM_047443010.1</a><a href="/protein/XP_047298966.1">XP_047298966.1</a>  adenylate cyclase type 3 isoform X16</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047443008.1">XM_047443008.1</a><a href="/protein/XP_047298964.1">XP_047298964.1</a>  adenylate cyclase type 3 isoform X14</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B3KNM3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B3KNM3</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_017003187.2">XM_017003187.2</a><a href="/protein/XP_016858676.1">XP_016858676.1</a>  adenylate cyclase type 3 isoform X5</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_011532491.2">XM_011532491.2</a><a href="/protein/XP_011530793.1">XP_011530793.1</a>  adenylate cyclase type 3 isoform X4</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a>
</dd>
<dt class="clear"> Conserved Domains (3) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_011530793.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=214485">smart00044</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">903</span><span class="cddto">1121</span></dt>
<dd class="clearfix"> CYCc; Adenylyl- / guanylyl cyclase, catalytic domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=278633">pfam00211</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">934</span><span class="cddto">1141</span></dt>
<dd class="clearfix"> Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=292831">pfam16214</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">44</span><span class="cddto">303</span></dt>
<dd class="clearfix"> AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_011532494.2">XM_011532494.2</a><a href="/protein/XP_011530796.1">XP_011530796.1</a>  adenylate cyclase type 3 isoform X13</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B3KNM3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B3KNM3</a>
</dd>
<dt class="clear"> Conserved Domains (3) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_011530796.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=214485">smart00044</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">859</span><span class="cddto">1077</span></dt>
<dd class="clearfix"> CYCc; Adenylyl- / guanylyl cyclase, catalytic domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=278633">pfam00211</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">890</span><span class="cddto">1097</span></dt>
<dd class="clearfix"> Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=292831">pfam16214</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">44</span><span class="cddto">303</span></dt>
<dd class="clearfix"> AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047443013.1">XM_047443013.1</a><a href="/protein/XP_047298969.1">XP_047298969.1</a>  adenylate cyclase type 3 isoform X19</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B3KNM3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B3KNM3</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047443007.1">XM_047443007.1</a><a href="/protein/XP_047298963.1">XP_047298963.1</a>  adenylate cyclase type 3 isoform X12</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_006711925.2">XM_006711925.2</a><a href="/protein/XP_006711988.1">XP_006711988.1</a>  adenylate cyclase type 3 isoform X3</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a>
</dd>
<dt class="clear"> Conserved Domains (3) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_006711988.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=214485">smart00044</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">906</span><span class="cddto">1124</span></dt>
<dd class="clearfix"> CYCc; Adenylyl- / guanylyl cyclase, catalytic domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=278633">pfam00211</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">937</span><span class="cddto">1144</span></dt>
<dd class="clearfix"> Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=292831">pfam16214</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">44</span><span class="cddto">303</span></dt>
<dd class="clearfix"> AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047443006.1">XM_047443006.1</a><a href="/protein/XP_047298962.1">XP_047298962.1</a>  adenylate cyclase type 3 isoform X11</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_017003189.2">XM_017003189.2</a><a href="/protein/XP_016858678.1">XP_016858678.1</a>  adenylate cyclase type 3 isoform X10</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B3KNM3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B3KNM3</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047443011.1">XM_047443011.1</a><a href="/protein/XP_047298967.1">XP_047298967.1</a>  adenylate cyclase type 3 isoform X17</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B3KNM3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B3KNM3</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_011532493.2">XM_011532493.2</a><a href="/protein/XP_011530795.1">XP_011530795.1</a>  adenylate cyclase type 3 isoform X9</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B3KNM3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B3KNM3</a>
</dd>
<dt class="clear"> Conserved Domains (3) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_011530795.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=214485">smart00044</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">879</span><span class="cddto">1097</span></dt>
<dd class="clearfix"> CYCc; Adenylyl- / guanylyl cyclase, catalytic domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=278633">pfam00211</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">910</span><span class="cddto">1117</span></dt>
<dd class="clearfix"> Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=292831">pfam16214</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">44</span><span class="cddto">303</span></dt>
<dd class="clearfix"> AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_011532490.2">XM_011532490.2</a><a href="/protein/XP_011530792.1">XP_011530792.1</a>  adenylate cyclase type 3 isoform X2</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a>
</dd>
<dt class="clear"> Conserved Domains (3) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_011530792.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=214485">smart00044</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">924</span><span class="cddto">1142</span></dt>
<dd class="clearfix"> CYCc; Adenylyl- / guanylyl cyclase, catalytic domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=278633">pfam00211</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">955</span><span class="cddto">1162</span></dt>
<dd class="clearfix"> Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=292831">pfam16214</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">44</span><span class="cddto">303</span></dt>
<dd class="clearfix"> AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_017003188.2">XM_017003188.2</a><a href="/protein/XP_016858677.1">XP_016858677.1</a>  adenylate cyclase type 3 isoform X7</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_011532489.2">XM_011532489.2</a><a href="/protein/XP_011530791.1">XP_011530791.1</a>  adenylate cyclase type 3 isoform X1</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a>
</dd>
<dt class="clear"> Conserved Domains (3) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_011530791.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=214485">smart00044</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">925</span><span class="cddto">1143</span></dt>
<dd class="clearfix"> CYCc; Adenylyl- / guanylyl cyclase, catalytic domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=278633">pfam00211</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">956</span><span class="cddto">1163</span></dt>
<dd class="clearfix"> Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=292831">pfam16214</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">44</span><span class="cddto">303</span></dt>
<dd class="clearfix"> AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_011532492.3">XM_011532492.3</a><a href="/protein/XP_011530794.1">XP_011530794.1</a>  adenylate cyclase type 3 isoform X6</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a>
</dd>
<dt class="clear"> Conserved Domains (3) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_011530794.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=214485">smart00044</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">925</span><span class="cddto">1126</span></dt>
<dd class="clearfix"> CYCc; Adenylyl- / guanylyl cyclase, catalytic domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=278633">pfam00211</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">310</span><span class="cddto">516</span></dt>
<dd class="clearfix"> Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=292831">pfam16214</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">44</span><span class="cddto">303</span></dt>
<dd class="clearfix"> AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047443005.1">XM_047443005.1</a><a href="/protein/XP_047298961.1">XP_047298961.1</a>  adenylate cyclase type 3 isoform X8</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047443016.1">XM_047443016.1</a><a href="/protein/XP_047298972.1">XP_047298972.1</a>  adenylate cyclase type 3 isoform X23</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/U3KQ91" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">U3KQ91</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_017003191.1">XM_017003191.1</a><a href="/protein/XP_016858680.1">XP_016858680.1</a>  adenylate cyclase type 3 isoform X21</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/U3KQ91" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">U3KQ91</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047443015.1">XM_047443015.1</a><a href="/protein/XP_047298971.1">XP_047298971.1</a>  adenylate cyclase type 3 isoform X22</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/U3KQ91" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">U3KQ91</a>
</dd>
</dl>
</li>
</ol>
<h4 id="rna-p29776560">RNA</h4>
<ol>
<li>
<p><a href="/nuccore/XR_007068865.1">XR_007068865.1</a> RNA Sequence </p>
<dl></dl>
</li>
</ol>
<h3 id="refseq-sequencedescription-p157634272">Alternate T2T-CHM13v2.0</h3>
<h4 id="genomic-p157634272">Genomic </h4>
<ol>
<li>
<p>NC_060926.1 Alternate T2T-CHM13v2.0</p>
<dl>
<dt>Range</dt>
<dd class="rs-range">
<span>24853918..24954979 complement</span>
</dd>
<dt>Download</dt>
<dd><a href="/nuccore/NC_060926.1?from=24853918&amp;to=24954979&amp;report=genbank&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=NC_060926.1?from=24853918&amp;to=24954979&amp;report=genbank&amp;strand=true">GenBank</a>, <a href="/nuccore/NC_060926.1?from=24853918&amp;to=24954979&amp;report=fasta&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=NC_060926.1?from=24853918&amp;to=24954979&amp;report=fasta&amp;strand=true">FASTA</a>, <a href="/nuccore/NC_060926.1?from=24838758&amp;to=24970137&amp;report=graph&amp;content=5&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=NC_060926.1?from=24838758&amp;to=24970137&amp;report=graph&amp;content=5&amp;strand=true">Sequence Viewer (Graphics)</a></dd>
</dl>
</li>
</ol>
<h4 id="mrnaandproteins-p128847360">mRNA and Protein(s) </h4>
<ol>
<li>
<p><a href="/nuccore/XM_054340246.1">XM_054340246.1</a><a href="/protein/XP_054196221.1">XP_054196221.1</a>  adenylate cyclase type 3 isoform X20</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B3KNM3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B3KNM3</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054340244.1">XM_054340244.1</a><a href="/protein/XP_054196219.1">XP_054196219.1</a>  adenylate cyclase type 3 isoform X18</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B3KNM3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B3KNM3</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054340241.1">XM_054340241.1</a><a href="/protein/XP_054196216.1">XP_054196216.1</a>  adenylate cyclase type 3 isoform X15</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054340242.1">XM_054340242.1</a><a href="/protein/XP_054196217.1">XP_054196217.1</a>  adenylate cyclase type 3 isoform X16</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054340240.1">XM_054340240.1</a><a href="/protein/XP_054196215.1">XP_054196215.1</a>  adenylate cyclase type 3 isoform X14</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B3KNM3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B3KNM3</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054340231.1">XM_054340231.1</a><a href="/protein/XP_054196206.1">XP_054196206.1</a>  adenylate cyclase type 3 isoform X5</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054340230.1">XM_054340230.1</a><a href="/protein/XP_054196205.1">XP_054196205.1</a>  adenylate cyclase type 3 isoform X4</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054340239.1">XM_054340239.1</a><a href="/protein/XP_054196214.1">XP_054196214.1</a>  adenylate cyclase type 3 isoform X13</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B3KNM3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B3KNM3</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054340245.1">XM_054340245.1</a><a href="/protein/XP_054196220.1">XP_054196220.1</a>  adenylate cyclase type 3 isoform X19</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B3KNM3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B3KNM3</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054340238.1">XM_054340238.1</a><a href="/protein/XP_054196213.1">XP_054196213.1</a>  adenylate cyclase type 3 isoform X12</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054340229.1">XM_054340229.1</a><a href="/protein/XP_054196204.1">XP_054196204.1</a>  adenylate cyclase type 3 isoform X3</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054340237.1">XM_054340237.1</a><a href="/protein/XP_054196212.1">XP_054196212.1</a>  adenylate cyclase type 3 isoform X11</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054340236.1">XM_054340236.1</a><a href="/protein/XP_054196211.1">XP_054196211.1</a>  adenylate cyclase type 3 isoform X10</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B3KNM3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B3KNM3</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054340243.1">XM_054340243.1</a><a href="/protein/XP_054196218.1">XP_054196218.1</a>  adenylate cyclase type 3 isoform X17</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B3KNM3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B3KNM3</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054340235.1">XM_054340235.1</a><a href="/protein/XP_054196210.1">XP_054196210.1</a>  adenylate cyclase type 3 isoform X9</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B3KNM3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B3KNM3</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054340228.1">XM_054340228.1</a><a href="/protein/XP_054196203.1">XP_054196203.1</a>  adenylate cyclase type 3 isoform X2</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054340233.1">XM_054340233.1</a><a href="/protein/XP_054196208.1">XP_054196208.1</a>  adenylate cyclase type 3 isoform X7</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054340227.1">XM_054340227.1</a><a href="/protein/XP_054196202.1">XP_054196202.1</a>  adenylate cyclase type 3 isoform X1</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054340232.1">XM_054340232.1</a><a href="/protein/XP_054196207.1">XP_054196207.1</a>  adenylate cyclase type 3 isoform X6</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054340234.1">XM_054340234.1</a><a href="/protein/XP_054196209.1">XP_054196209.1</a>  adenylate cyclase type 3 isoform X8</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B7ZLX9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">B7ZLX9</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054340249.1">XM_054340249.1</a><a href="/protein/XP_054196224.1">XP_054196224.1</a>  adenylate cyclase type 3 isoform X23</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/U3KQ91" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">U3KQ91</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054340247.1">XM_054340247.1</a><a href="/protein/XP_054196222.1">XP_054196222.1</a>  adenylate cyclase type 3 isoform X21</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/U3KQ91" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">U3KQ91</a>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054340248.1">XM_054340248.1</a><a href="/protein/XP_054196223.1">XP_054196223.1</a>  adenylate cyclase type 3 isoform X22</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/U3KQ91" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=109&amp;nlmid=&amp;db=gene">U3KQ91</a>
</dd>
</dl>
</li>
</ol>
<h4 id="rna-p2690544">RNA</h4>
<ol>
<li>
<p><a href="/nuccore/XR_008486253.1">XR_008486253.1</a> RNA Sequence </p>
<dl></dl>
</li>
</ol>
</div>
</div>
</div>
<div class="rprt-section gene-related-sequences">
<section class="rprt-section-header" id="related-sequences">
<h2 id="header-related-sequences">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-related-sequences .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Related sequences</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Related_Sequences" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<table id="proteinTblId" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/109/data/related-sequences/',webserviceParams: 'p$l=Ajax', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
<thead>
<tr>
<th colspan="2" id="rs-nucleo">Nucleotide</th>
<th rowspan="2" id="rs-protein">Protein</th>
</tr>
<tr>
<th id="rs-heading">Heading</th>
<th id="rs-heading-acc">Accession and Version</th>
</tr>
</thead>
<tbody></tbody>
</table>
<table id="proteinTblId" class="jig-ncbigrid" data-jigconfig="isPageable:true, pageSize:25">
<thead>
<tr>
<th class="proteinTblTh" rowspan="2" id="rs-prot-acc">Protein Accession</th>
<th class="proteinTblTh" colspan="2" id="rs-link">Links</th>
</tr>
<tr>
<th id="rs-genepept">GenPept Link</th>
<th id="rs-uniprot">UniProtKB Link</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="rs-prot-acc">O60266.3</td>
<td headers="rs-link rs-genepept">
<a href="/protein/118572618" ref="ordinalpos=1&amp;ncbi_uid=109&amp;link_uid=118572618">GenPept</a>
</td>
<td>
<a href="https://www.uniprot.org/uniprot/O60266">UniProtKB/Swiss-Prot:O60266</a>
</td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<div class="rprt-section gene-additional-links">
<section class="rprt-section-header" id="additional-links"><h2 id="header-additional-links"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-additional-links .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Additional links</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Additional_Links" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
<div class="rprt-section-body" style="">
<h3 class="withnote" id="genelinkout">
<a class="jig-ncbitoggler">Gene LinkOut</a>
</h3><div>
<p>The following <a href="https://www.ncbi.nlm.nih.gov/projects/linkout/index.html">LinkOut</a> resources are supplied by external providers. These providers are responsible for maintaining the links. </p>
<div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Chemical Information</span>
</a>
<ul>
<li><span class="free-rsc"></span>Interologous Interaction Database</li>
<ul>
<li>
<a target="_blank" href="http://ophid.utoronto.ca/redirect/ncbi/human?proteins=109" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7911">
<span>Interologous Interaction Database</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>MilliporeSigma</li>
<ul>
<li>
<a target="_blank" href="https://www.sigmaaldrich.com/catalog/genes/ADCY3?lang=en&amp;region=US" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9978">
<span>Adcy3 products</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Molecular Biology Databases</span>
</a>
<ul>
<li><span class="free-rsc"></span>Bgee database</li>
<ul>
<li>
<a target="_blank" href="https://www.bgee.org/gene/ENSG00000138031" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10418">
<span>ADCY3 gene expression</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>BioGPS</li>
<ul>
<li>
<a target="_blank" href="http://biogps.org/gene/109/" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5059">
<span>BioGPS</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>BioGRID Open Repository of CRISPR Screens (ORCS)</li>
<ul>
<li>
<a target="_blank" href="https://orcs.thebiogrid.org/Gene/109" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10164">
<span>BioGRID CRISPR Screen Phenotypes (26 hits/1410 screens)</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Domain Mapping of Disease Mutations</li>
<ul>
<li>
<a target="_blank" href="http://bioinf.umbc.edu/DMDM/gene_prot_page.php?id=109" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7642">
<span>ADCY3</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Eukaryotic Promoter Database</li>
<ul>
<li>
<a target="_blank" href="http://epd.vital-it.ch/cgi-bin/get_doc?db=hgEpdNew&amp;format=genome&amp;entry=ADCY3_1" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9624">
<span>ADCY3_1</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>GlyGen glycoinformatics resource</li>
<ul>
<li>
<a target="_blank" href="https://glygen.org/protein/O60266" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10227">
<span>GlyGen glycoinformatics resource</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Guide to Pharmacology</li>
<ul>
<li>
<a target="_blank" href="https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1280" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8191">
<span>adenylyl cyclase 3 gene</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Human eFP Browser</li>
<ul>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Circulatory_Respiratory&amp;modeInput=Absolute&amp;primaryGene=109" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Nervous&amp;modeInput=Absolute&amp;primaryGene=109" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Reproductive&amp;modeInput=Absolute&amp;primaryGene=109" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
</ul>
<li>Ingenuity Pathways Analysis</li>
<ul>
<li>
<a target="_blank" href="http://partnersolution.ingenuity.com/?cid=97ae3f91eab87a&amp;p1=Entrez&amp;p2=GV&amp;s=&amp;ipaUri=%2Fpa%2Fapi%2Fv2%2Fgeneview%3Fapplicationname%3DEntrez%26geneId%3D109%26geneidtype%3Dentrezgene" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5628">
<span>Ingenuity Pathways Analysis</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>InnateDB</li>
<ul>
<li>
<a target="_blank" href="http://www.innatedb.com/getGeneCard.do?id=34125" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7894">
<span>InnateDB</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>InterMine</li>
<ul>
<li>
<a target="_blank" href="https://www.humanmine.org/humanmine/search?keyword=ENSG00000138031" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9169">
<span>InterMine</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Kyoto Encyclopedia of Genes and Genomes</li>
<ul>
<li>
<a target="_blank" href="http://www.genome.jp/dbget-bin/www_bget?hsa:109" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5174">
<span>Kyoto Encyclopedia of Genes and Genomes</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>OMA Browser: Orthologous MAtrix</li>
<ul>
<li>
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN61762/" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9822">
<span>OMA Browser: Orthologous MAtrix</span>
</a>
</li>
<li>
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN61764/" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9822">
<span>OMA Browser: Orthologous MAtrix</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>OrthoDB catalog of orthologs</li>
<ul>
<li>
<a target="_blank" href="https://www.orthodb.org/?ncbi=109" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8178">
<span>Orthologs</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Pharmacogenomics Knowledge Base</li>
<ul>
<li>
<a target="_blank" href="https://www.pharmgkb.org/gene/PA164741137" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=4067">
<span>Annotated Pharmacogenomic Information for ADCY3 [PharmGKB]</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>PhosphoSitePlus</li>
<ul>
<li>
<a target="_blank" href="https://www.phosphosite.org/entrezGeneIdAction.action?id=109" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7987">
<span>PhosphoSitePlus® - comprehensive post-translational modification resource</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>The Gene Wiki</li>
<ul>
<li>
<a target="_blank" href="https://en.wikipedia.org/wiki/ADCY3" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=6933">
<span>The Gene Wiki</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>The Weizmann Institute of Science GeneCards and MalaCards databases</li>
<ul>
<li>
<a target="_blank" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=ADCY3" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8598">
<span>GeneCard for ADCY3</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Research Materials</span>
</a>
<ul>
<li><span class="order-rsc"></span>Addgene Non-profit plasmid repository</li>
<ul>
<li>
<a target="_blank" href="https://addgene.org//browse/gene/109" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5304">
<span>Get Plasmids - Addgene</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>Bio-Techne</li>
<ul>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/adenylate-cyclase-3/proteins-enzymes?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=proteins" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>Adenylate Cyclase 3 Proteins</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/adenylate-cyclase-3/antibodies?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=antibodies" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>Adenylate Cyclase 3 Antibodies</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/adenylate-cyclase-3/elisa-kits?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=elisakits" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>Adenylate Cyclase 3 ELISA Kits</span>
</a>
</li>
</ul>
<li>ExactAntigen/Labome</li>
<ul>
<li>
<a target="_blank" href="https://www.labome.com/review/gene/human/ADCY3-antibody.html" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5753">
<span>reagent review</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.labome.com/gene/human/ADCY3-antibody.html" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5753">
<span>reagents</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GenScript latest version of gene cDNA ORF Clone</li>
<ul>
<li>
<a target="_blank" href="http://www.genscript.com/gene/109" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8012">
<span>GenScript latest version of gene cDNA ORF Clone</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GeneCopoeia Inc.</li>
<ul>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=11&amp;field=5&amp;key=109" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order shRNA clones</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=22&amp;field=5&amp;key=109" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order promoter clone</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=1&amp;field=5&amp;key=109" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order full-length ORF clone</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GeneTex Inc</li>
<ul>
<li>
<a target="_blank" href="https://www.genetex.com/Product/Search?geneid=109&amp;type=01&amp;page=1" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8117">
<span>Find Quality Antibodies</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>Kazusa DNA Research Institute</li>
<ul>
<li>
<a target="_blank" href="http://www.kazusa.or.jp/kop/dsearch/symsearch.cgi?keyword=ADCY3;" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=3267">
<span>Kazusa DNA Research Institute</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>OriGene</li>
<ul>
<li>
<a target="_blank" href="https://www.origene.com/search?q=Adcy3" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7994">
<span>Order Adcy3 cDNA clone/Protein/Antibody/RNAi</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Tools</span>
</a>
<ul>
<li><span class="free-rsc"></span>GeneMANIA</li>
<ul>
<li>
<a target="_blank" href="http://genemania.org/link?o=9606&amp;g=109" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7529">
<span>GeneMANIA</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open">
<span>Miscellaneous</span>
</a>
<ul>
<li><span class="free-rsc"></span>Reactome</li>
<ul>
<li>
<a target="_blank" href="https://reactome.org/PathwayBrowser/#/R-HSA-9709957" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=4914">
<span>Reactome Event:Sensory Perception</span>
</a>
</li>
<li>
<a target="_blank" href="https://reactome.org/PathwayBrowser/#/R-HSA-1430728" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=4914">
<span>Reactome Event:Metabolism</span>
</a>
</li>
<li>
<a target="_blank" href="https://reactome.org/PathwayBrowser/#/R-HSA-1643685" ref="itool=Gene_FullReport&amp;uid=109&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=4914">
<span>Reactome Event:Disease</span>
</a>
</li>
</ul>
</ul>
</div>
</div>
</div>
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</div>
</div>
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<h2 class="offscreen_noflow">Supplemental Content</h2>
<div id="gene-sidebar">
<div>
<div class="portlet brieflink dis-table-of-contents">
<div class="portlet_head">
<div class="portlet_title">
<h3>Table of contents</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_TableOfContents" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li class="">
<a href="#summary">Summary</a>
</li>
<li class="">
<a href="#genomic-context">Genomic context</a>
</li>
<li class="">
<a href="#genomic-regions-transcripts-products">Genomic regions, transcripts, and products</a>
</li>
<li class="">
<a href="#gene-expression">Expression</a>
</li>
<li class="">
<a href="#bibliography">Bibliography</a>
</li>
<li class="">
<a href="#phenotypes">Phenotypes</a>
</li>
<li class="">
<a href="#variation">Variation</a>
</li>
<li class="">
<a href="#HIV-1-interactions">HIV-1 interactions</a>
</li>
<li class="">
<a href="#pathways">Pathways from PubChem</a>
</li>
<li class="">
<a href="#interactions">Interactions</a>
</li>
<li class="">
<a href="#general-gene-info">General gene information</a>
<div class="subsection-links"><a href="#gene-markers">Markers</a>, <a href="#CloneNames">Clone Names</a>, <a href="#homology">Homology</a>, <a href="#gene-ontology">Gene Ontology</a></div>
</li>
<li class="">
<a href="#general-protein-info">General protein information</a>
</li>
<li class="">
<a href="#reference-sequences">NCBI Reference Sequences (RefSeq)</a>
</li>
<li class="">
<a href="#related-sequences">Related sequences</a>
</li>
<li class="">
<a href="#additional-links">Additional links</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-genomesbrowser brieflink dis-genomesbrowser">
<div class="portlet_head">
<div class="portlet_title">
<h3>Genome Browsers</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GenomeBrowsers.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GenomeBrowsers" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GenomeBrowsers.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="#">Loading...</a>
</li>
</ul>
</div>
</div>
<div class="portlet dis-related-info brieflink">
<div class="portlet_head">
<div class="portlet_title">
<h3>Related information</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter"></a>
</div>
<div class="portlet_content DiscoveryDbLinks">
<ul>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clone/order/gene/109" ref="log$=recordlinks">Order cDNA clone</a>
<div class="brieflinkpop offscreen_noflow">Order cDNA clone</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_alltarget_list&amp;from_uid=109" ref="log$=recordlinks">BioAssay by Target (List)</a>
<div class="brieflinkpop offscreen_noflow">BioAssays related to the gene by protein target or RNAi target</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="//pubchem.ncbi.nlm.nih.gov/assay/bioactivity.html?geneid=109" ref="log$=recordlinks">BioAssay by Target (Summary)</a>
<div class="brieflinkpop offscreen_noflow">Summarized PubChem Data on the gene, showing the active data by default</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_target&amp;from_uid=109" ref="log$=recordlinks">BioAssay, by Gene target</a>
<div class="brieflinkpop offscreen_noflow">PubChem BioAssays done on the Gene target</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai_active&amp;from_uid=109" ref="log$=recordlinks">BioAssays, RNAi Target, Active</a>
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent, which is identified as a hit in a RNAi screening and flagged as "active" in the corresponding BioAssay record</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai&amp;from_uid=109" ref="log$=recordlinks">BioAssays, RNAi Target, Tested</a>
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/bioproject?LinkName=gene_bioproject&amp;from_uid=109" ref="log$=recordlinks">BioProjects</a>
<div class="brieflinkpop offscreen_noflow">BioProjects related to a gene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/biosystems?LinkName=gene_biosystems&amp;from_uid=109" ref="log$=recordlinks">BioSystems</a>
<div class="brieflinkpop offscreen_noflow">BioSystems</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/CCDS/CcdsBrowse.cgi?REQUEST=GENEID&amp;DATA=109" ref="log$=recordlinks">CCDS</a>
<div class="brieflinkpop offscreen_noflow">Link to CCDS</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar&amp;from_uid=109" ref="log$=recordlinks">ClinVar</a>
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/cdd?LinkName=gene_cdd&amp;from_uid=109" ref="log$=recordlinks">Conserved Domains</a>
<div class="brieflinkpop offscreen_noflow">Related CDD</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/dbvar?LinkName=gene_dbvar&amp;from_uid=109" ref="log$=recordlinks">dbVar</a>
<div class="brieflinkpop offscreen_noflow">Link from Gene to dbVar</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc&amp;from_uid=109" ref="log$=recordlinks">Full text in PMC</a>
<div class="brieflinkpop offscreen_noflow">PMC links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc_nucleotide&amp;from_uid=109" ref="log$=recordlinks">Full text in PMC_nucleotide</a>
<div class="brieflinkpop offscreen_noflow">Full text in PubMedCentral identified from shared sequence links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/sparcle?LinkName=gene_sparcle&amp;from_uid=109" ref="log$=recordlinks">Functional Class</a>
<div class="brieflinkpop offscreen_noflow">Functional class of the sequence domain architecture</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gap?LinkName=gene_gap&amp;from_uid=109" ref="log$=recordlinks">GAP</a>
<div class="brieflinkpop offscreen_noflow">GAP Links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gene?LinkName=gene_gene_neighbors&amp;from_uid=109" ref="log$=recordlinks">Gene neighbors</a>
<div class="brieflinkpop offscreen_noflow">Overlapping genes and two nearest non-overlapping genes on either side</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/genome?LinkName=gene_genome&amp;from_uid=109" ref="log$=recordlinks">Genome</a>
<div class="brieflinkpop offscreen_noflow">Related Genome</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/geoprofiles?LinkName=gene_geoprofiles&amp;from_uid=109" ref="log$=recordlinks">GEO Profiles</a>
<div class="brieflinkpop offscreen_noflow">Related GEO</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gtr/tests/?term=109[geneid]" ref="log$=recordlinks">GTR</a>
<div class="brieflinkpop offscreen_noflow">Tests for this gene in the NIH Genetic Testing Registry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/homologene?LinkName=gene_homologene&amp;from_uid=109" ref="log$=recordlinks">HomoloGene</a>
<div class="brieflinkpop offscreen_noflow">Related HomoloGene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/medgen?LinkName=gene_medgen_diseases&amp;from_uid=109" ref="log$=recordlinks">MedGen</a>
<div class="brieflinkpop offscreen_noflow">Related information in MedGen</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore&amp;from_uid=109" ref="log$=recordlinks">Nucleotide</a>
<div class="brieflinkpop offscreen_noflow">Link to related Nucleotide entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/omim?LinkName=gene_omim&amp;from_uid=109" ref="log$=recordlinks">OMIM</a>
<div class="brieflinkpop offscreen_noflow">Link to related OMIM entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/probe?LinkName=gene_probe&amp;from_uid=109" ref="log$=recordlinks">Probe</a>
<div class="brieflinkpop offscreen_noflow">Related Probe entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein&amp;from_uid=109" ref="log$=recordlinks">Protein</a>
<div class="brieflinkpop offscreen_noflow">Link to related protein entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pccompound?LinkName=gene_pccompound&amp;from_uid=109" ref="log$=recordlinks">PubChem Compound</a>
<div class="brieflinkpop offscreen_noflow">PubChem Compounds</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcsubstance?LinkName=gene_pcsubstance&amp;from_uid=109" ref="log$=recordlinks">PubChem Substance</a>
<div class="brieflinkpop offscreen_noflow">PubChem Substances</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed&amp;from_uid=109" ref="log$=recordlinks">PubMed</a>
<div class="brieflinkpop offscreen_noflow">Link to related PubMed entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_rif&amp;from_uid=109" ref="log$=recordlinks">PubMed (GeneRIF)</a>
<div class="brieflinkpop offscreen_noflow">Link to related PubMed article from GeneRIFs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_citedinomim&amp;from_uid=109" ref="log$=recordlinks">PubMed (OMIM)</a>
<div class="brieflinkpop offscreen_noflow">Gene links to PubMed derived from omim_pubmed_cited links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_pmc_nucleotide&amp;from_uid=109" ref="log$=recordlinks">PubMed(nucleotide/PMC)</a>
<div class="brieflinkpop offscreen_noflow">Citations in PubMed identified from shared sequence and PMC links.</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein_refseq&amp;from_uid=109" ref="log$=recordlinks">RefSeq Proteins</a>
<div class="brieflinkpop offscreen_noflow">Link to Protein RefSeqs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore_refseqrna&amp;from_uid=109" ref="log$=recordlinks">RefSeq RNAs</a>
<div class="brieflinkpop offscreen_noflow">Link to Nucleotide RefSeq RNAs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar_specific&amp;from_uid=109" ref="log$=recordlinks">Related gene-specific medical variations</a>
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/snp?LinkName=gene_snp&amp;from_uid=109" ref="log$=recordlinks">SNP</a>
<div class="brieflinkpop offscreen_noflow">Related SNP records</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/taxonomy?LinkName=gene_taxonomy&amp;from_uid=109" ref="log$=recordlinks">Taxonomy</a>
<div class="brieflinkpop offscreen_noflow">Link to related taxonomy entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/variation/view/?q=109[geneid]" ref="log$=recordlinks">Variation Viewer</a>
<div class="brieflinkpop offscreen_noflow">Related Variants</div>
</li>
</ul>
</div>
</div>
<div class="portlet dis-links-to-other-res brieflink">
<div class="portlet_head">
<div class="portlet_title">
<h3>Links to other resources</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_LinksTwo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:234">HGNC</a>
</li>
<li>
<a href="http://www.ensembl.org/id/ENSG00000138031">Ensembl</a>
</li>
<li>
<a href="https://www.alliancegenome.org/gene/HGNC:234">AllianceGenome</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=geneid&amp;org=9606&amp;l=109">AceView</a>
</li>
<li>
<a href="http://zearth.kazusa.or.jp/huge/gfpage/KIAA0511">HUGE</a>
</li>
<li>
<a href="http://www.pharmgkb.org/gene/PA26">PharmGKB</a>
</li>
<li>
<a href="http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&amp;position=NM_001377128">UCSC</a>
</li>
<li>
<a href="https://phgkb.cdc.gov/PHGKB/huGEPedia.action?firstQuery=ADCY3&amp;geneID=109&amp;typeOption=gene&amp;which=2&amp;pubOrderType=pubD&amp;typeSubmit=GO&amp;check=y">HuGE Navigator</a>
</li>
<li>
<a href="http://www.genome.jp/dbget-bin/www_bget?hsa:109">KEGG</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-general-info">
<div class="portlet_head">
<div class="portlet_title">
<h3>General information</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GeneralInfo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="/pmc/?term=PMC4383897+OR+PMC3013746+OR+PMC1761442+OR+PMC539985">About Gene</a>
</li>
<li>
<a href="/books/NBK3840">FAQ</a>
</li>
<li>
<a href="https://ftp.ncbi.nlm.nih.gov/gene/">FTP site</a>
</li>
<li>
<a href="/books/NBK3841/">Help</a>
</li>
<li>
<a href="/books/NBK3842/">My NCBI help</a>
</li>
<li>
<a href="/books/NBK21085/">NCBI Handbook</a>
</li>
<li>
<a href="/gene/statistics/">Statistics</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-related-sites">
<div class="portlet_head">
<div class="portlet_title">
<h3>Related sites</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_RelatedSites" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://www.ncbi.nlm.nih.gov/BLAST">BLAST</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/genome">Genome</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/bioproject">BioProject</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/genome/gdv/">Genome Data Viewer</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/geo">GEO</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/omim">OMIM</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/probe">Probe</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/RefSeq">RefSeq</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-feedback">
<div class="portlet_head">
<div class="portlet_title">
<h3>Feedback</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_Feedback" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://support.ncbi.nlm.nih.gov/ics/support/ticketnewwizard.asp?style=classic&amp;deptID=28049">Contact Help Desk</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/RefSeq/update.cgi?geneid=109&amp;symbol=ADCY3">Submit Correction</a>
</li>
<li>
<a href="/gene/submit-generif?geneId=109&amp;sym=ADCY3&amp;name=adenylate cyclase 3&amp;org=Homo sapiens">Submit GeneRIF</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-subscription">
<div class="portlet_head">
<div class="portlet_title">
<h3>Subscription</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Subscription.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_Subscription" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Subscription.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://www.ncbi.nlm.nih.gov/mailman/listinfo/refseq-announce">RefSeq</a>
</li>
</ul>
</div>
</div>
</div>
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<h3>Recent activity</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="recent_activity" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.Shutter"></a>
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Clear
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Turn On
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<ul id="activity">
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67c9d5f8f4a390645ef82616">ADCY3 adenylate cyclase 3 [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">ADCY3 adenylate cyclase 3 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:109</div></div>
<div class="tertiary">Gene</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67c9d5f6a68b6b5afc320216">adenylate cyclase type 3 isoform 2 [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">adenylate cyclase type 3 isoform 2 [Homo sapiens]<div class="brieflinkpopdesc">gi|148536830|ref|NP_004027.2|</div></div>
<div class="tertiary">Protein</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67c9d5f4f4a390645ef80af7">ADCY2 adenylate cyclase 2 [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">ADCY2 adenylate cyclase 2 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:108</div></div>
<div class="tertiary">Gene</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67c9d5f384f3725e59f83851">adenylate cyclase type 2 [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">adenylate cyclase type 2 [Homo sapiens]<div class="brieflinkpopdesc">gi|115387102|ref|NP_065433.2|</div></div>
<div class="tertiary">Protein</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67c9d5f084f3725e59f826cd">ADCY1 adenylate cyclase 1 [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">ADCY1 adenylate cyclase 1 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:107</div></div>
<div class="tertiary">Gene</div>
</li>
</ul>
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