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1440 lines
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133 KiB
XML
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<h1 class="res_name"><a href="/gene/">Gene</a></h1>
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<h2 class="res_tagline">Genes and mapped phenotypes</h2>
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<div class="search"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="books">Books</option><option value="pubmed">PubMed</option><option value="clinvar">ClinVar</option><option value="gene" selected="selected" class="last" data-ac_dict="gene">Gene</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly" data-ac_dict="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene" data-ac_dict="gene">Gene</option><option value="genome" data-ac_dict="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen">MedGen</option><option value="mesh">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore" data-ac_dict="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein" data-ac_dict="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search Gene. Use up and down arrows to choose an item from the autocomplete." value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="dictionary:'gene',disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'yes',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div><ul class="searchlinks inline_list"><set></set><li><a href="/gene/advanced">Advanced</a></li><li class="help"><a id="help" class="jig-ncbihelpwindow" target="ncbihelp" name="help" href="/books/NBK3841/">Help</a></li></ul></div>
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<input name="EntrezSystem2.PEntrez.Gene.Gene_PageController.PreviousPageName" sid="1" type="hidden" value="results" />
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<div id="faceted_search" class="facet_hide">
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<h2 class="offscreen_noflow">Result Filters</h2>
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<div class="facet_cont" data-db="gene" data-default_grps="fg_gene-sources,fg_categories,fg_sequence-content,fg_status" data-sd="db:'gene',op:'select',term:'',qk:'12697',linkname:'',idsfromresult:'108491823',extra:''"><ul class="facet" data-filter_id="gene-sources" id="_gene-sources"><li class="filter_grp "><div class="clearfix"><h3>Gene sources</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="genomic">Genomic</a></li></ul></li></ul><ul class="facet" data-filter_id="categories" id="_categories"><li class="filter_grp "><div class="clearfix"><h3>Categories</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="annotated-genes">Annotated genes</a></li></ul></li></ul><ul class="facet" data-filter_id="sequence-content" id="_sequence-content"><li class="filter_grp "><div class="clearfix"><h3>Sequence content</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="refseq">RefSeq</a></li></ul></li></ul><ul class="facet" data-filter_id="status" id="_status"><li class="filter_grp "><div class="clearfix"><h3>Status</h3><a href="#" data-value_id="" class="clear clear_show">Clear</a></div><ul><li class="fil_val selected"><a href="#" data-value_id="current-only">Current</a><span class="fcount">(1)</span></li></ul></li></ul><div id="chr-location-facet-wrapper" data-bid="MCID_67d3934c4f3d5e000d2dd788" data-hid="MCID_67d2a666fe1ad803e8633767" data-qky="12697" class="disabled" style="display:none"><ul class="facet" data-filter_id="chromosomal-region" id="_chromosomal-region" data-of="yes"><li class="filter_grp of_grp"><div class="clearfix"><h3>Chromosome locations</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><a id="facet_ofchromosomal-region" href="#facet_of_divchromosomal-region" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'middle left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '375px'" data-value_id="fetch_more">more...</a><div id="facet_of_divchromosomal-region" style="display:none;" class="of_popup"><h4>Chromosome locations</h4><label for="organism-filter" style="width:100%;margin-bottom:.2em;" class="">Select an organism by typing or scrolling</label><input type="text" placeholder="Enter text to narrow down the list" id="organism-filter" style="width:98%;" autocomplete="off" /><br /><div id="chr-region-tax-list"><select id="of_chromosomal-region" size="9" class="chr-region-tax-list" style="width:100%;"></select></div><div id="chr-location-info-ctrl" data-disabled="disabled"><div class="chr-field"><label for="chr-name">Chromosome</label><br /><select id="chr-name" class="chr-field" disabled="disabled"></select></div><div class="chr-field"><label for="chr-from">From</label><br /><input type="text" name="chr-from" id="chr-from" disabled="disabled" class="chr-field" /></div><div class="chr-field"><label for="chr-to">To</label><br /><input type="text" name="chr-to" id="chr-to" disabled="disabled" class="chr-field" /></div></div><div class="actions clearfix"><button class="jig-ncbibutton of_add apply-chr" data-jigconfig="'color': 'ui-ncbibutton-blue'">Apply</button></div></div></ul></li></ul></div><ul class="facet facet_reset"><li><a href="#" data-value_id="reset">Clear all</a></li></ul><ul class="facet_tools"><li><a id="more_filter_groups_link" href="#more_filter_groups" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'top left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '180px'">
|
||
Show additional filters</a></li><div id="more_filter_groups" style="display:none;" class="facets_dialog"><button class="ui-ncbipopper-close-button ui-ncbipopper-close-button-generated ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-blue" generated="true" role="button" aria-disabled="false"><span class="ui-button-text">x</span></button><h4>Additional filters</h4><ul class="filter_groups_more facet"><li><input type="checkbox" id="fg_gene-sources" /><label for="fg_gene-sources">Gene sources</label></li><li><input type="checkbox" id="fg_categories" /><label for="fg_categories">Categories</label></li><li><input type="checkbox" id="fg_sequence-content" /><label for="fg_sequence-content">Sequence content</label></li><li><input type="checkbox" id="fg_status" /><label for="fg_status">Status</label></li><li><input type="checkbox" id="fg_chromosomal-region" /><label for="fg_chromosomal-region">Chromosome locations</label></li><li><input id="fg_field_search" type="checkbox" /><label for="fg_field_search">Search fields</label></li></ul><div class="actions clearfix"><button class="filter_groups_more_apply jig-ncbibutton primary-action" id="filter_groups_apply" data-jigconfig="'color': 'ui-ncbibutton-blue'">Show</button></div></div></ul><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetsUrlFrag" sid="1" type="hidden" value="filters=current-only" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetSubmitted" sid="1" type="hidden" value="false" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.BMFacets" sid="1" type="hidden" value="" /></div>
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<span style="display: block; text-align: center;">S</span>
|
||
<span style="display: block; text-align: center;">I</span>
|
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<span style="display: block; text-align: center;">D</span>
|
||
<span style="display: block; text-align: center;">E</span>
|
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<span style="display: block; text-align: center;">B</span>
|
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<span style="display: block; text-align: center;">A</span>
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<span style="display: block; text-align: center;">R</span>
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</script></h4><div id="send_to_menu" class="tabPopper send_to"><fieldset><legend>Choose Destination</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendTo" sid="1" value="File" id="dest_File" /><label for="dest_File">File</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendTo" sid="2" value="AddToClipboard" id="dest_AddToClipboard" /><label for="dest_AddToClipboard">Clipboard</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendTo" sid="3" value="AddToCollections" id="dest_AddToCollections" /><label for="dest_AddToCollections">Collections</label></li></ul></fieldset><div class="submenu file" id="submenu_File" style="display: none;"><p id="submenu_File_hint" class="hidden"></p><ul><li><label for="file_format">Format</label><select id="file_format" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.FFormat" sid="1"><option value="full_report" format="text" selected="selected">Full Report (text)</option><option value="gene_table" format="text">Gene Table (text)</option><option value="docsum" format="text">Summary (text)</option><option value="tabular" format="text">Tabular (text)</option><option value="asn1" format="text">ASN.1</option><option value="xml" format="text">XML</option><option value="uilist" format="text">UI List</option></select></li></ul><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendToSubmit" sid="1" class="button_apply file ncbipopper-close-button" type="submit" cmd="File">Create File</button></div><div class="submenu addtoclipboard" id="submenu_AddToClipboard" style="display: none;"><p id="submenu_AddToClipboard_hint" class="hidden"></p><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendToSubmit" sid="2" class="button_apply clipboard ncbipopper-close-button" type="submit" cmd="AddToClipboard">Add to Clipboard</button></div><div class="submenu addtocollections" id="submenu_AddToCollections" style="display: none;"><p id="submenu_AddToCollections_hint" class="hidden"></p><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendToSubmit" sid="3" class="button_apply collections ncbipopper-close-button" type="submit" cmd="AddToCollections">Add to Collections</button></div></div><div><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.FileFormat" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastPresentation" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Presentation" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastPageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Sort" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastSort" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.FileSort" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Format" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastFormat" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PrevPageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PrevPresentation" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PrevSort" sid="1" type="hidden" value="" /><input type="hidden" id="coll_startindex" name="CollectionStartIndex" value="1" /></div></div>
|
||
<div>
|
||
|
||
|
||
|
||
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|
||
<div class="">
|
||
<div><span id="result_sel" class="nowrap"></span><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_ResultsController.ResultCount" sid="1" type="hidden" id="resultcount" value="1" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_ResultsController.RunLastQuery" sid="1" type="hidden" /></div>
|
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|
||
<div id="messagearea" class="empty">
|
||
|
||
|
||
|
||
|
||
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|
||
<div class="rprt full-rprt">
|
||
<div>
|
||
<div class="rprt-header">
|
||
<input type="hidden" id="gene-tax-id" value="9606" />
|
||
<h1 class="title" id="gene-name"><span class="gn" style="padding-right:.5em;">LOC108491823</span> CTTNBP2 intron enhancer-blocking element 7-1-1 [ <em class="tax">Homo sapiens</em> (human)
|
||
]
|
||
</h1>
|
||
<span class="geneid">Gene ID: 108491823, updated on
|
||
4-Mar-2025</span>
|
||
</div>
|
||
<div class="download-datasets">
|
||
<script type="text/javascript" src="https://cdnjs.cloudflare.com/ajax/libs/axios/0.23.0/axios.min.js"></script>
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<svg alt="download" class="dlbtn-icon" x="0px" y="0px" width="15px" height="15px" viewBox="0 0 60 60" enable-background="new 0 0 60 60" xml:space="preserve">
|
||
<g>
|
||
<polygon points="48.75,36.25 48.75,48.75 11.25,48.75 11.25,36.25 5,36.25 5,55 55,55 55,36.25 "></polygon>
|
||
<polygon points="42.5,23.75 36.25,23.75 36.25,5 23.75,5 23.75,23.75 17.5,23.75 30,42.5 "></polygon>
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||
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|
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<a href="#">Download Datasets</a>
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<input type="checkbox" id="datasets-ft-transcript-seq-fasta" value="FASTA_RNA" class="download-datasets-included-seq" />
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|
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<label for="datasets-ft-protein-seq-fasta">Protein sequences(FASTA)</label>
|
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</div>
|
||
<p style="margin-left:5px;">In addition, your package will include a detailed data report in both TSV and JSONL formats.</p>
|
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<div class="input-group">
|
||
<label for="datasets-download-file-name">File name</label>
|
||
<input type="text" id="datasets-download-file-name" placeholder="Name your file" style="padding:5px;" value="LOC108491823_datasets.zip" />
|
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<span class="ui-button-text">Download</span>
|
||
</button>
|
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</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-body">
|
||
|
||
|
||
<div class="rprt-section gene-summary">
|
||
<section class="rprt-section-header" id="summary">
|
||
<h2 id="header-summary">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-summary .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Summary</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
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<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
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|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div id="summaryDiv" class="section">
|
||
<dl id="summaryDl">
|
||
<dt class="noline"> Gene symbol </dt>
|
||
<dd class="noline">LOC108491823</dd>
|
||
<dt> Gene description </dt>
|
||
<dd>CTTNBP2 intron enhancer-blocking element 7-1-1</dd>
|
||
<dt>Gene type</dt>
|
||
<dd>biological region</dd>
|
||
<dt>Feature type(s)</dt>
|
||
<dd>regulatory: DNase_I_hypersensitive_site, enhancer_blocking_element</dd>
|
||
<dt>RefSeq status</dt>
|
||
<dd>REVIEWED</dd>
|
||
<dt>Organism</dt>
|
||
<dd class="tax">
|
||
<a href="/Taxonomy/Browser/wwwtax.cgi?id=9606" ref="ordinalpos=1&ncbi_uid=108491823&link_uid=9606">Homo sapiens</a>
|
||
</dd>
|
||
<dt>Lineage</dt>
|
||
<dd class="tax">Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo</dd>
|
||
<dt>Also known as</dt>
|
||
<dd>DHS+48.9kb</dd>
|
||
<dt>Summary</dt>
|
||
<dd>This genomic region is located in an intron of the CTTNBP2 (cortactin binding protein 2) gene on chromosome 7, and is also located approximately 48 kb from the 3' end of the CFTR (cystic fibrosis transmembrane conductance regulator) gene. It was identified as a putative enhancer-blocking chromatin insulator based on CTCF association and DNase I hypersensitivity in multiple cell types by ChIP-seq and genome-wide chromatin accessibility assays. A DNase I hypersensitive site, DHS+48.9kb, was also detected by the DNase-chip procedure. This region was validated as a functional enhancer-blocking element based on its ability to block activation of a gamma-globin promoter by the beta-globin HS2 enhancer when positioned between the enhancer and promoter in a lentiviral reporter assay in K562 erythroleukemia cells. This region has also been shown to associate with Rad21, a cohesin complex subunit that is known to interact with CTCF, and it can form looping interactions with the CFTR promoter and the -80.1 kb and -20.9 kb CFTR regulatory elements. [provided by RefSeq, Oct 2018]</dd>
|
||
<dt style="padding-top:.5em;">
|
||
<span class="new-icon">NEW</span>
|
||
</dt>
|
||
<dd style="padding-top:.5em;">
|
||
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/108491823/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="gene_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Gene table</a></strong>
|
||
<br />
|
||
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/108491823/products/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="transcript_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Transcript table</a></strong>
|
||
</dd>
|
||
</dl>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-genomic-context">
|
||
<section class="rprt-section-header" id="genomic-context">
|
||
<h2 id="header-genomic-context">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-context .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Genomic context</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Genomic_Context" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div class="gc_cont">
|
||
<div class="gt_cont_contents">
|
||
<div style="float:right"><span>See LOC108491823 in </span><a href="/genome/gdv/?context=gene&acc=108491823" class="link-to-gdv genome-browser-link" data-genome-browser-link-sort="1" data-acc="GCF_000001405.40">Genome Data Viewer</a> </div>
|
||
<dl class="dl-chr-info" style="float:left;margin-top:0;">
|
||
<dt>Location: </dt>
|
||
<dd>
|
||
<span style="display:inline-block;">7q31</span>
|
||
</dd>
|
||
</dl>
|
||
</div>
|
||
<div class="ui-ncbigrid-outer-div" id="genomic-context-tbl-location">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-jigconfig="">
|
||
<thead>
|
||
<tr>
|
||
<th style="max-width:15%">Annotation release</th>
|
||
<th style="max-width:10%">Status</th>
|
||
<th>Assembly</th>
|
||
<th>
|
||
<span title="Chromosome">Chr</span>
|
||
</th>
|
||
<th>Location</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td>RS_2024_08</td>
|
||
<td>current</td>
|
||
<td>GRCh38.p14 (<a href="/assembly/GCF_000001405.40/" ref="ncbi_uid=108491823&link_uid=GCF_000001405.40">GCF_000001405.40</a>)</td>
|
||
<td>7</td>
|
||
<td>NC_000007.14 (117715346..117716425) </td>
|
||
</tr>
|
||
<tr>
|
||
<td>RS_2024_08</td>
|
||
<td>current</td>
|
||
<td>T2T-CHM13v2.0 (<a href="/assembly/GCF_009914755.1/" ref="ncbi_uid=108491823&link_uid=GCF_009914755.1">GCF_009914755.1</a>)</td>
|
||
<td>7</td>
|
||
<td>NC_060931.1 (119030737..119031823) </td>
|
||
</tr>
|
||
<tr>
|
||
<td>RS_2024_09</td>
|
||
<td>previous assembly</td>
|
||
<td>GRCh37.p13 (<a href="/assembly/GCF_000001405.25/" ref="ncbi_uid=108491823&link_uid=GCF_000001405.25">GCF_000001405.25</a>)</td>
|
||
<td>7</td>
|
||
<td>NC_000007.13 (117355400..117356479) </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<p class="withnote margin_t2em"><strong>Chromosome 7 - NC_000007.14</strong><img usemap="#nbrMap108491823_568815591" border="0" alt="Genomic Context describing neighboring genes" src="/gutils/geneneighb.fcgi?geneid=108491823&nuc_gi=568815591&n0=LOC105375468&n1=LOC111674466&n2=LOC113219447&n3=LOC111674463&n4=CFTR&n5=LOC111674464&n6=LOC113664106&n7=LOC113664107&n8=LOC113219471&n9=CFTR-AS1&n10=LOC113219472&n11=LOC111674473&n12=LOC111674474&n13=LOC111674475&n14=LOC111674472&n15=LOC113633875&n16=LOC113633874&n17=LOC113633876&n18=LOC126860160&n19=LOC113633877&n20=LOC111674467&n21=LOC111674468&n22=LOC111674477&n23=LOC111674471&n24=LOC111674470&n25=LOC113523647&n26=LOC111674479&n27=CTTNBP2&n28=LOC113219474&n29=LOC108491823&n30=LOC105375469&n31=LOC129662101&n32=LOC113219475&n33=LOC113604967&n34=LOC113225348&n35=LOC113225349&n36=LOC113225350&n37=LOC127457480&n38=LOC127457481&n39=LOC113225351&n40=LOC129662102&n41=LOC126860161&n42=LOC113225352&n43=LOC105375470&n44=LSM8&n45=LOC129662103&n46=LOC129999189" /><map name="nbrMap108491823_568815591" id="nbrMap108491823_568815591">
|
||
<area shape="rect" onMouseOver="showtip(this,event,'uncharacterized LOC105375468')" onMouseOut="hidetip()" coords="2,23,77,31" alt="Neighboring gene uncharacterized LOC105375468" href="/gene/105375468" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'DNase I hypersensitive site -20.9 kb upstream of CFTR')" onMouseOut="hidetip()" coords="7,35,77,43" alt="Neighboring gene DNase I hypersensitive site -20.9 kb upstream of CFTR" href="/gene/111674466" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'greater CFTR locus negative regulatory element NR9')" onMouseOut="hidetip()" coords="14,47,84,55" alt="Neighboring gene greater CFTR locus negative regulatory element NR9" href="/gene/113219447" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'CFTR promoter region')" onMouseOut="hidetip()" coords="15,59,85,67" alt="Neighboring gene CFTR promoter region" href="/gene/111674463" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'CFTR intron 1 enhancer')" onMouseOut="hidetip()" coords="22,71,92,79" alt="Neighboring gene CFTR intron 1 enhancer" href="/gene/111674464" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'CFTR intron 2 DNase I hypersensitive site')" onMouseOut="hidetip()" coords="31,83,101,91" alt="Neighboring gene CFTR intron 2 DNase I hypersensitive site" href="/gene/113664106" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'CFTR intron 3 DNase I hypersensitive site')" onMouseOut="hidetip()" coords="31,95,101,103" alt="Neighboring gene CFTR intron 3 DNase I hypersensitive site" href="/gene/113664107" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'greater CFTR locus negative regulatory element CR19')" onMouseOut="hidetip()" coords="45,107,115,115" alt="Neighboring gene greater CFTR locus negative regulatory element CR19" href="/gene/113219471" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'CF transmembrane conductance regulator')" onMouseOut="hidetip()" coords="57,119,169,127" alt="Neighboring gene CF transmembrane conductance regulator" href="/gene/1080" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'greater CFTR locus negative regulatory element CR20')" onMouseOut="hidetip()" coords="58,131,128,139" alt="Neighboring gene greater CFTR locus negative regulatory element CR20" href="/gene/113219472" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'DNase I hypersensitive sites in intron 10ab of CFTR')" onMouseOut="hidetip()" coords="61,143,131,151" alt="Neighboring gene DNase I hypersensitive sites in intron 10ab of CFTR" href="/gene/111674473" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'DNase I hypersensitive site in intron 10c of CFTR')" onMouseOut="hidetip()" coords="65,155,135,163" alt="Neighboring gene DNase I hypersensitive site in intron 10c of CFTR" href="/gene/111674474" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'CFTR antisense RNA 1')" onMouseOut="hidetip()" coords="67,167,119,175" alt="Neighboring gene CFTR antisense RNA 1" href="/gene/111082987" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'CFTR intron 11 enhancer')" onMouseOut="hidetip()" coords="68,179,138,187" alt="Neighboring gene CFTR intron 11 enhancer" href="/gene/111674475" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'DNase I hypersensitive sites in introns 16 and 17a of CFTR')" onMouseOut="hidetip()" coords="78,23,148,31" alt="Neighboring gene DNase I hypersensitive sites in introns 16 and 17a of CFTR" href="/gene/111674472" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'CFTR intron 18a DNase I hypersensitive site')" onMouseOut="hidetip()" coords="82,35,152,43" alt="Neighboring gene CFTR intron 18a DNase I hypersensitive site" href="/gene/113633875" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'DNase I hypersensitive site in intron 18 of CFTR')" onMouseOut="hidetip()" coords="84,191,154,199" alt="Neighboring gene DNase I hypersensitive site in intron 18 of CFTR" href="/gene/113633874" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'CFTR intron 18b DNase I hypersensitive site')" onMouseOut="hidetip()" coords="85,47,155,55" alt="Neighboring gene CFTR intron 18b DNase I hypersensitive site" href="/gene/113633876" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'MED14-independent group 3 enhancer GRCh37_chr7:117270281-117271480')" onMouseOut="hidetip()" coords="89,59,159,67" alt="Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:117270281-117271480" href="/gene/126860160" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'CFTR intron 19 DNase I hypersensitive site')" onMouseOut="hidetip()" coords="93,71,163,79" alt="Neighboring gene CFTR intron 19 DNase I hypersensitive site" href="/gene/113633877" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'CFTR intron 20 enhancer')" onMouseOut="hidetip()" coords="95,203,165,211" alt="Neighboring gene CFTR intron 20 enhancer" href="/gene/111674467" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'CFTR intron 21 enhancer')" onMouseOut="hidetip()" coords="102,83,172,91" alt="Neighboring gene CFTR intron 21 enhancer" href="/gene/111674468" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'CFTR intron 23 enhancer')" onMouseOut="hidetip()" coords="105,95,175,103" alt="Neighboring gene CFTR intron 23 enhancer" href="/gene/111674477" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'DNase I hypersensitive region 5.4 to 7.4 kb downstream of CFTR')" onMouseOut="hidetip()" coords="109,215,179,223" alt="Neighboring gene DNase I hypersensitive region 5.4 to 7.4 kb downstream of CFTR" href="/gene/111674471" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'DNase I hypersensitive region 15.6 kb downstream of CFTR')" onMouseOut="hidetip()" coords="113,227,183,235" alt="Neighboring gene DNase I hypersensitive region 15.6 kb downstream of CFTR" href="/gene/111674470" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'CFTR +21.5 kb DNase I hypersensitive site')" onMouseOut="hidetip()" coords="116,107,186,115" alt="Neighboring gene CFTR +21.5 kb DNase I hypersensitive site" href="/gene/113523647" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'CFTR +36.6 kb downstream enhancer')" onMouseOut="hidetip()" coords="123,167,193,175" alt="Neighboring gene CFTR +36.6 kb downstream enhancer" href="/gene/111674479" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'greater CFTR locus negative regulatory element NR11')" onMouseOut="hidetip()" coords="128,239,198,247" alt="Neighboring gene greater CFTR locus negative regulatory element NR11" href="/gene/113219474" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'uncharacterized LOC105375469')" onMouseOut="hidetip()" coords="129,251,199,259" alt="Neighboring gene uncharacterized LOC105375469" href="/gene/105375469" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'ReSE screen-validated silencer GRCh37_chr7:117372591-117372808')" onMouseOut="hidetip()" coords="137,143,207,151" alt="Neighboring gene ReSE screen-validated silencer GRCh37_chr7:117372591-117372808" href="/gene/129662101" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'greater CFTR locus negative regulatory element NR12')" onMouseOut="hidetip()" coords="137,155,207,163" alt="Neighboring gene greater CFTR locus negative regulatory element NR12" href="/gene/113219475" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'DNase I hypersensitive site 83.7 kb downstream of CFTR')" onMouseOut="hidetip()" coords="146,179,216,187" alt="Neighboring gene DNase I hypersensitive site 83.7 kb downstream of CFTR" href="/gene/113604967" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'cortactin binding protein 2')" onMouseOut="hidetip()" coords="152,23,266,31" alt="Neighboring gene cortactin binding protein 2" href="/gene/83992" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'greater CFTR locus negative regulatory element CR27')" onMouseOut="hidetip()" coords="160,35,230,43" alt="Neighboring gene greater CFTR locus negative regulatory element CR27" href="/gene/113225348" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'greater CFTR locus negative regulatory element NR13')" onMouseOut="hidetip()" coords="161,47,231,55" alt="Neighboring gene greater CFTR locus negative regulatory element NR13" href="/gene/113225349" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'greater CFTR locus negative regulatory element CR28')" onMouseOut="hidetip()" coords="163,59,233,67" alt="Neighboring gene greater CFTR locus negative regulatory element CR28" href="/gene/113225350" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'OCT4-NANOG hESC enhancer GRCh37_chr7:117449968-117450716')" onMouseOut="hidetip()" coords="174,71,244,79" alt="Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:117449968-117450716" href="/gene/127457480" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'OCT4-NANOG hESC enhancer GRCh37_chr7:117450717-117451463')" onMouseOut="hidetip()" coords="174,83,244,91" alt="Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:117450717-117451463" href="/gene/127457481" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'greater CFTR locus negative regulatory element NR14')" onMouseOut="hidetip()" coords="181,95,251,103" alt="Neighboring gene greater CFTR locus negative regulatory element NR14" href="/gene/113225351" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'ReSE screen-validated silencer GRCh37_chr7:117499510-117499710')" onMouseOut="hidetip()" coords="197,107,267,115" alt="Neighboring gene ReSE screen-validated silencer GRCh37_chr7:117499510-117499710" href="/gene/129662102" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:117590690-117591889')" onMouseOut="hidetip()" coords="241,35,311,43" alt="Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:117590690-117591889" href="/gene/126860161" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'greater CFTR locus negative regulatory element NR19')" onMouseOut="hidetip()" coords="266,47,336,55" alt="Neighboring gene greater CFTR locus negative regulatory element NR19" href="/gene/113225352" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'uncharacterized LOC105375470')" onMouseOut="hidetip()" coords="336,23,413,31" alt="Neighboring gene uncharacterized LOC105375470" href="/gene/105375470" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'ReSE screen-validated silencer GRCh37_chr7:117830912-117831127')" onMouseOut="hidetip()" coords="353,35,423,43" alt="Neighboring gene ReSE screen-validated silencer GRCh37_chr7:117830912-117831127" href="/gene/129662103" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 26548')" onMouseOut="hidetip()" coords="353,47,423,55" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26548" href="/gene/129999189" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'LSM8 homolog, U6 small nuclear RNA associated')" onMouseOut="hidetip()" coords="392,59,423,67" alt="Neighboring gene LSM8 homolog, U6 small nuclear RNA associated" href="/gene/51691" />
|
||
</map>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-genomic-regions-transcripts-products">
|
||
<section class="rprt-section-header" id="genomic-regions-transcripts-products">
|
||
<h2 id="header-genomic-regions-transcripts-products">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-regions-transcripts-products .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Genomic regions, transcripts, and products</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Genomic_Regions_Transcripts_a" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div>
|
||
<div style="text-align:right;">Go to <a href="#reference-sequences">reference sequence details</a></div>
|
||
</div>
|
||
<div>
|
||
<p class="choose">
|
||
<label for="accession" class="label">Genomic Sequence: </label>
|
||
<select name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.accessionList" sid="1" id="accessionList" data-taxid="9606" data-geneid="108491823">
|
||
<option value="NC_000007.14_117715345_117716424">NC_000007.14 Chromosome 7 Reference GRCh38.p14 Primary Assembly</option>
|
||
<option value="NG_051342.1_100_1179">NG_051342.1 Biological Region</option>
|
||
<option value="NC_060931.1_119030736_119031822">NC_060931.1 Chromosome 7 Alternate T2T-CHM13v2.0</option>
|
||
<option value="NC_000007.13_117355399_117356478">NC_000007.13 Chromosome 7 Reference GRCh37.p13 Primary Assembly</option>
|
||
</select>
|
||
</p>
|
||
</div>
|
||
<div id="NC_000007" class="divAccession">
|
||
<div class="seq-viewer">
|
||
<p class="note-link">
|
||
<strong>Go to nucleotide:</strong>
|
||
<a title="Nucleotide Graphic report" href="/nuccore/NC_000007.14?report=graph&from=117715183&to=117716586&app_context=Gene&assm_context=GCF_000001405.40" ref="ordinalpos=1&ncbi_uid=108491823&link_uid=NC_000007.14">Graphics</a>
|
||
<a title="Nucleotide FASTA report" href="/nuccore/NC_000007.14?report=fasta&from=117715346&to=117716425" ref="ordinalpos=1&ncbi_uid=108491823&link_uid=NC_000007.14">FASTA</a>
|
||
<a title="Nucleotide GenBank report" href="/nuccore/NC_000007.14?report=genbank&from=117715346&to=117716425" ref="ordinalpos=1&ncbi_uid=108491823&link_uid=NC_000007.14">GenBank</a>
|
||
</p>
|
||
<div id="divNC_000007" class="SeqViewerApp" style="clear:both;" data-sv="appname=ncbigene&embedded=true&noslider=1&id=NC_000007.14&from=117715183&to=117716586&app_context=Gene&assm_context=GCF_000001405.40">
|
||
<a href="?appname=ncbigene&embedded=true&noslider=1&id=NC_000007.14&from=117715183&to=117716586&app_context=Gene&assm_context=GCF_000001405.40"></a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000007.14" sid="1" type="hidden" id="nucleotideLink_NC_000007_14_117715345_117716424" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NC_000007.14?report=graph&amp;from=117715183&amp;to=117716586&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" ref="ordinalpos=1&amp;ncbi_uid=108491823&amp;link_uid=NC_000007.14">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NC_000007.14?report=fasta&amp;from=117715346&amp;to=117716425" ref="ordinalpos=1&amp;ncbi_uid=108491823&amp;link_uid=NC_000007.14">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NC_000007.14?report=genbank&amp;from=117715346&amp;to=117716425" ref="ordinalpos=1&amp;ncbi_uid=108491823&amp;link_uid=NC_000007.14">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000007.14" sid="1" type="hidden" id="relString_NC_000007_14_117715345_117716424" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000007.14&amp;from=117715183&amp;to=117716586&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NG_051342.1" sid="1" type="hidden" id="nucleotideLink_NG_051342_1_100_1179" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NG_051342.1?report=graph&amp;from=1&amp;to=1341&amp;tracks=[key:sequence_track,name:Sequence,display_name:Sequence,category:Sequence,annots:Sequence,ShowLabel:false][key:aggregate_feature_track,subkey:biological_region,annots:Unnamed,name:Biological%20region,display_name:Biological%20region,Layout:Layered][key:gene_model_track,name:Genes---Unnamed,display_name:Genes,annots:Unnamed,Options:ShowAllButGenes,SNPs:false,CDSProductFeats:false,ShowLabelsForAllFeatures:true,HighlightMode:2][key:SNP_track,name:SNP,annots:SNP,Layout:Adaptive][key:SNP_Bins_track,name:Clinical Variants][key:SNP_Bins_track,name:Cited Variants][key:GWAS_track,name:GWAS Tracks,display_name:Association Results][key:alignment_track,category:Alignments,annots:Unnamed][key:alignment_track,category:Alignments,annots:NA000079160.1][key:alignment_track,category:Alignments,annots:NA000010065.1]" ref="ordinalpos=1&amp;ncbi_uid=108491823&amp;link_uid=NG_051342.1">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NG_051342.1?report=fasta&amp;from=101&amp;to=1180" ref="ordinalpos=1&amp;ncbi_uid=108491823&amp;link_uid=NG_051342.1">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NG_051342.1?report=genbank&amp;from=101&amp;to=1180" ref="ordinalpos=1&amp;ncbi_uid=108491823&amp;link_uid=NG_051342.1">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NG_051342.1" sid="1" type="hidden" id="relString_NG_051342_1_100_1179" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NG_051342.1&amp;from=1&amp;to=1341&amp;tracks=[key:sequence_track,name:Sequence,display_name:Sequence,category:Sequence,annots:Sequence,ShowLabel:false][key:aggregate_feature_track,subkey:biological_region,annots:Unnamed,name:Biological%20region,display_name:Biological%20region,Layout:Layered][key:gene_model_track,name:Genes---Unnamed,display_name:Genes,annots:Unnamed,Options:ShowAllButGenes,SNPs:false,CDSProductFeats:false,ShowLabelsForAllFeatures:true,HighlightMode:2][key:SNP_track,name:SNP,annots:SNP,Layout:Adaptive][key:SNP_Bins_track,name:Clinical Variants][key:SNP_Bins_track,name:Cited Variants][key:GWAS_track,name:GWAS Tracks,display_name:Association Results][key:alignment_track,category:Alignments,annots:Unnamed][key:alignment_track,category:Alignments,annots:NA000079160.1][key:alignment_track,category:Alignments,annots:NA000010065.1]" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_060931.1" sid="1" type="hidden" id="nucleotideLink_NC_060931_1_119030736_119031822" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NC_060931.1?report=graph&amp;from=119030573&amp;to=119031985&amp;app_context=Gene&amp;assm_context=GCF_009914755.1" ref="ordinalpos=1&amp;ncbi_uid=108491823&amp;link_uid=NC_060931.1">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NC_060931.1?report=fasta&amp;from=119030737&amp;to=119031823" ref="ordinalpos=1&amp;ncbi_uid=108491823&amp;link_uid=NC_060931.1">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NC_060931.1?report=genbank&amp;from=119030737&amp;to=119031823" ref="ordinalpos=1&amp;ncbi_uid=108491823&amp;link_uid=NC_060931.1">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_060931.1" sid="1" type="hidden" id="relString_NC_060931_1_119030736_119031822" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_060931.1&amp;from=119030573&amp;to=119031985&amp;app_context=Gene&amp;assm_context=GCF_009914755.1" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000007.13" sid="1" type="hidden" id="nucleotideLink_NC_000007_13_117355399_117356478" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NC_000007.13?report=graph&amp;from=117355237&amp;to=117356640&amp;app_context=Gene&amp;assm_context=GCF_000001405.25" ref="ordinalpos=1&amp;ncbi_uid=108491823&amp;link_uid=NC_000007.13">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NC_000007.13?report=fasta&amp;from=117355400&amp;to=117356479" ref="ordinalpos=1&amp;ncbi_uid=108491823&amp;link_uid=NC_000007.13">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NC_000007.13?report=genbank&amp;from=117355400&amp;to=117356479" ref="ordinalpos=1&amp;ncbi_uid=108491823&amp;link_uid=NC_000007.13">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000007.13" sid="1" type="hidden" id="relString_NC_000007_13_117355399_117356478" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000007.13&amp;from=117355237&amp;to=117356640&amp;app_context=Gene&amp;assm_context=GCF_000001405.25" />
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div class="rprt-section gene-bibliography">
|
||
<section class="rprt-section-header" id="bibliography"><h2 id="header-bibliography"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-bibliography .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Bibliography</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Bibliography" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
|
||
<div class="rprt-section-body" style="">
|
||
<div class="generif-pubmed">
|
||
<h3 id="relatedarticlesinpubmed">
|
||
<a href="#" class="jig-ncbitoggler-open">Related articles in PubMed</a>
|
||
</h3>
|
||
<div class="generefbl-link">
|
||
<ol class="generef-link">
|
||
<li>
|
||
<a href="/pubmed/24098520/" ref="ordinalpos=1&ncbi_uid=108491823&link_uid=24098520">Identification and characterization of enhancer-blocking insulators to reduce retroviral vector genotoxicity.</a>
|
||
<span class="pubmed-auth-date"> Groth AC, <em>et al</em>. PLoS One, 2013. PMID 24098520, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC3789682/" ref="ordinalpos=0&ncbi_uid=108491823&link_uid=PMC3789682">Free PMC Article</a></span></span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/22955980/" ref="ordinalpos=2&ncbi_uid=108491823&link_uid=22955980">Widespread plasticity in CTCF occupancy linked to DNA methylation.</a>
|
||
<span class="pubmed-auth-date"> Wang H, <em>et al</em>. Genome Res, 2012 Sep. PMID 22955980, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC3431485/" ref="ordinalpos=0&ncbi_uid=108491823&link_uid=PMC3431485">Free PMC Article</a></span></span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/26673704/" ref="ordinalpos=3&ncbi_uid=108491823&link_uid=26673704">Differential contribution of cis-regulatory elements to higher order chromatin structure and expression of the CFTR locus.</a>
|
||
<span class="pubmed-auth-date"> Yang R, <em>et al</em>. Nucleic Acids Res, 2016 Apr 20. PMID 26673704, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC4838340/" ref="ordinalpos=0&ncbi_uid=108491823&link_uid=PMC4838340">Free PMC Article</a></span></span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/22422629/" ref="ordinalpos=4&ncbi_uid=108491823&link_uid=22422629">Perinuclear positioning of the inactive human cystic fibrosis gene depends on CTCF, A-type lamins and an active histone deacetylase.</a>
|
||
<span class="pubmed-auth-date"> Muck JS, <em>et al</em>. J Cell Biochem, 2012 Aug. PMID 22422629</span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/26184320/" ref="ordinalpos=5&ncbi_uid=108491823&link_uid=26184320">Chromatin Dynamics in the Regulation of CFTR Expression.</a>
|
||
<span class="pubmed-auth-date"> Gosalia N, <em>et al</em>. Genes (Basel), 2015 Jul 13. PMID 26184320, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC4584316/" ref="ordinalpos=0&ncbi_uid=108491823&link_uid=PMC4584316">Free PMC Article</a></span></span>
|
||
</li>
|
||
</ol>
|
||
<p class="see-all-pm">
|
||
<a href="/pubmed?LinkName=gene_pubmed&from_uid=108491823" title="See all 11 citations in Pubmed">See all (11) citations in PubMed</a>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="generif-pubmed generif">
|
||
<h3 id="generifsgenereferencesintofunctions">
|
||
<a href="#" class="jig-ncbitoggler-open">GeneRIFs: Gene References Into Functions</a>
|
||
</h3>
|
||
<div>
|
||
<a href="/gene/about-generif" class="whatisthis">What's a GeneRIF?</a>
|
||
<div class="submit-genrif">
|
||
<span>Submit:</span>
|
||
<a href="/gene/submit-generif/?geneId=108491823&sym=LOC108491823&name=&org=Homo sapiens">New GeneRIF</a>
|
||
<a href="/RefSeq/update.cgi?geneid=108491823&symbol=LOC108491823;task=fixpub">Correction</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-phenotypes">
|
||
<section class="rprt-section-header" id="phenotypes">
|
||
<h2 id="header-phenotypes">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-phenotypes .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Phenotypes</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Phenotype" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body info-phenotype">
|
||
<p class="nochild-link">
|
||
<a href="/gap/PheGenI?tab=1&gene=108491823">Review eQTL and phenotype association data in this region using PheGenI</a>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-variation">
|
||
<section class="rprt-section-header" id="variation">
|
||
<h2 id="header-variation">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-variation .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Variation</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.variation" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<p class="nochild-link">
|
||
<a href="/clinvar/?term=LOC108491823[gene]" ref="log$=recordlinks">See variants in ClinVar</a>
|
||
</p>
|
||
<p class="nochild-link">
|
||
<a href="/variation/view/?q=108491823[geneid]&assm=GCF_000001405.25" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh37.p13)">See Variation Viewer (GRCh37.p13)</a>
|
||
</p>
|
||
<set></set>
|
||
<set></set>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="rprt-section gene-general-gene-info">
|
||
<section class="rprt-section-header" id="general-gene-info">
|
||
<h2 id="header-general-gene-info">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-gene-info .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">General gene information</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.General_Gene_Information" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
|
||
<div class="rprt-section-body" style="">
|
||
|
||
|
||
<div></div>
|
||
|
||
|
||
<!--<component id="Gene_InfoPathway"/>-->
|
||
|
||
<div class="infosec info-comment" id="info-comment">
|
||
<h3 id="other-names">
|
||
<a class="jig-ncbitoggler-open">Other Names</a>
|
||
</h3>
|
||
<ul class="geneinfo-subsec">
|
||
<li>CFTR +48.9 kb DNase I hypersensitive site</li>
|
||
<li>chromatin insulator 7-1-1</li>
|
||
</ul>
|
||
</div>
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-reference-sequences">
|
||
<section class="rprt-section-header" id="reference-sequences">
|
||
<h2 id="header-reference-sequences">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-reference-sequences .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">NCBI Reference Sequences (RefSeq)</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.NCBI_Reference_Sequences_RefS" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<p>
|
||
<span class="new-icon">NEW</span>
|
||
<strong>Try the new <a href="/datasets/tables/genes/?table_type=transcripts&ids=108491823&utm_source=gene&utm_medium=referral&utm_campaign=refseq" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report." data-ga-category="refseq" data-ga-action="click_datasets_link" data-ga-label="transcript_table">Transcript table</a></strong>
|
||
</p>
|
||
<h3 class="genomerefseqs gene_std_toggler" id="refseqset-independent">
|
||
<a class="jig-ncbitoggler-open">RefSeqs maintained independently of Annotated
|
||
Genomes</a>
|
||
</h3>
|
||
<div class="genomerefseqs_slave">
|
||
<p class="desc"> These reference sequences exist independently of genome builds. <a href="#refseq-expl" id="expl-refseg">Explain</a></p>
|
||
<p id="refseq-expl"> These reference sequences are curated independently of the genome
|
||
annotation cycle, so their versions may not match the RefSeq versions in the current
|
||
genome build. Identify version mismatches by comparing the version of the RefSeq in
|
||
this section to the one reported in <a href="#geneGenomic regions, transcripts, and products">Genomic regions,
|
||
transcripts, and products</a> above. </p>
|
||
<h4 id="genomic-p69188224">Genomic </h4>
|
||
<ol>
|
||
<li>
|
||
<p>NG_051342.1 </p>
|
||
<dl>
|
||
<dt>Range</dt>
|
||
<dd class="rs-range">
|
||
<span>101..1180</span>
|
||
</dd>
|
||
<dt>Download</dt>
|
||
<dd><a href="/nuccore/NG_051342.1?from=101&to=1180&report=genbank" ref="ordinalpos=1&ncbi_uid=108491823&link_uid=NG_051342.1?from=101&to=1180&report=genbank">GenBank</a>, <a href="/nuccore/NG_051342.1?from=101&to=1180&report=fasta" ref="ordinalpos=1&ncbi_uid=108491823&link_uid=NG_051342.1?from=101&to=1180&report=fasta">FASTA</a>, <a href="/nuccore/NG_051342.1?from=1&to=1341&report=graph&content=5" ref="ordinalpos=1&ncbi_uid=108491823&link_uid=NG_051342.1?from=1&to=1341&report=graph&content=5">Sequence Viewer (Graphics)</a></dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
</div>
|
||
<h3 class="genomerefseqs gene_std_toggler" id="annotatedrefseq-title">
|
||
<a class="jig-ncbitoggler-open">RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08</a>
|
||
</h3>
|
||
<div class="genomerefseqs_slave">
|
||
<p class="desc"> The following sections contain reference sequences that belong to a
|
||
specific genome build. <a href="#" id="expl-genomes">Explain</a></p>
|
||
<p id="expl-genomes-desc" style="display:none">This section includes genomic Reference
|
||
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
|
||
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
|
||
assemblies. Model RNAs and proteins are also reported here.</p>
|
||
<h3 id="refseq-sequencedescription-p142494128">Reference GRCh38.p14 Primary Assembly</h3>
|
||
<h4 id="genomic-p142494128">Genomic </h4>
|
||
<ol>
|
||
<li>
|
||
<p>NC_000007.14 Reference GRCh38.p14 Primary Assembly</p>
|
||
<dl>
|
||
<dt>Range</dt>
|
||
<dd class="rs-range">
|
||
<span>117715346..117716425</span>
|
||
</dd>
|
||
<dt>Download</dt>
|
||
<dd><a href="/nuccore/NC_000007.14?from=117715346&to=117716425&report=genbank" ref="ordinalpos=1&ncbi_uid=108491823&link_uid=NC_000007.14?from=117715346&to=117716425&report=genbank">GenBank</a>, <a href="/nuccore/NC_000007.14?from=117715346&to=117716425&report=fasta" ref="ordinalpos=1&ncbi_uid=108491823&link_uid=NC_000007.14?from=117715346&to=117716425&report=fasta">FASTA</a>, <a href="/nuccore/NC_000007.14?from=117715183&to=117716586&report=graph&content=5" ref="ordinalpos=1&ncbi_uid=108491823&link_uid=NC_000007.14?from=117715183&to=117716586&report=graph&content=5">Sequence Viewer (Graphics)</a></dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
<h3 id="refseq-sequencedescription-p6695872">Alternate T2T-CHM13v2.0</h3>
|
||
<h4 id="genomic-p6695872">Genomic </h4>
|
||
<ol>
|
||
<li>
|
||
<p>NC_060931.1 Alternate T2T-CHM13v2.0</p>
|
||
<dl>
|
||
<dt>Range</dt>
|
||
<dd class="rs-range">
|
||
<span>119030737..119031823</span>
|
||
</dd>
|
||
<dt>Download</dt>
|
||
<dd><a href="/nuccore/NC_060931.1?from=119030737&to=119031823&report=genbank" ref="ordinalpos=1&ncbi_uid=108491823&link_uid=NC_060931.1?from=119030737&to=119031823&report=genbank">GenBank</a>, <a href="/nuccore/NC_060931.1?from=119030737&to=119031823&report=fasta" ref="ordinalpos=1&ncbi_uid=108491823&link_uid=NC_060931.1?from=119030737&to=119031823&report=fasta">FASTA</a>, <a href="/nuccore/NC_060931.1?from=119030573&to=119031985&report=graph&content=5" ref="ordinalpos=1&ncbi_uid=108491823&link_uid=NC_060931.1?from=119030573&to=119031985&report=graph&content=5">Sequence Viewer (Graphics)</a></dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-related-sequences">
|
||
<section class="rprt-section-header" id="related-sequences">
|
||
<h2 id="header-related-sequences">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-related-sequences .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Related sequences</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Related_Sequences" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div>
|
||
<table id="proteinTblId" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/108491823/data/related-sequences/',webserviceParams: 'p$l=Ajax', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
|
||
<thead>
|
||
<tr>
|
||
<th colspan="2" id="rs-nucleo">Nucleotide</th>
|
||
<th rowspan="2" id="rs-protein">Protein</th>
|
||
</tr>
|
||
<tr>
|
||
<th id="rs-heading">Heading</th>
|
||
<th id="rs-heading-acc">Accession and Version</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody></tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-additional-links">
|
||
|
||
<section class="rprt-section-header" id="additional-links"><h2 id="header-additional-links"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-additional-links .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Additional links</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Additional_Links" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
|
||
|
||
<div class="rprt-section-body" style="">
|
||
|
||
|
||
<h3 class="withnote" id="genelinkout">
|
||
<a class="jig-ncbitoggler">Gene LinkOut</a>
|
||
</h3><div>
|
||
<p>The following <a href="https://www.ncbi.nlm.nih.gov/projects/linkout/index.html">LinkOut</a> resources are supplied by external providers. These providers are responsible for maintaining the links. </p>
|
||
<div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Molecular Biology Databases</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>The Weizmann Institute of Science GeneCards and MalaCards databases</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=LOC108491823" ref="itool=Gene_FullReport&uid=108491823&nlmid=&db=gene&log$=linkoutlink&PrId=8598">
|
||
<span>GeneCard for LOC108491823</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="urls-in-genombrowser" style="display:none">
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div><input type="hidden" class="section_status_input" name="status_checked" id="status_checked" value="" /><input type="hidden" class="section_status_input" name="status_open" id="status_open" value="summary,region,context,bibliography,phenotypes,variation,hiv,interactions,pathways,geneInfo,proteinInfo,refSeq,related,links" /><input type="hidden" class="section_status_input" name="status_exist" id="status_exist" value="summary,context,region,bibliography,phenotypes,variation,geneInfo,refSeq,related,links" /><input type="hidden" class="section_status_input" name="status_closed" id="status_closed" value="" /><meta name="status_checked" content="" class="meta_section_status" /><meta name="status_open" content="summary,region,context,bibliography,phenotypes,variation,hiv,interactions,pathways,geneInfo,proteinInfo,refSeq,related,links" class="meta_section_status" /><meta name="status_exist" content="summary,context,region,bibliography,phenotypes,variation,geneInfo,refSeq,related,links" class="meta_section_status" /><meta name="status_closed" content="" class="meta_section_status" /><script type="text/javascript">
|
||
|
||
var section_status_meta = {
|
||
'status_checked': '',
|
||
'status_open': 'summary,region,context,bibliography,phenotypes,variation,hiv,interactions,pathways,geneInfo,proteinInfo,refSeq,related,links',
|
||
'status_exist': 'summary,context,region,bibliography,phenotypes,variation,geneInfo,refSeq,related,links',
|
||
'status_closed': ''
|
||
};
|
||
|
||
|
||
/*
|
||
for (var o in section_status_meta) {
|
||
var meta=document.createElement('meta');
|
||
meta.name = o;
|
||
meta.content = section_status_meta[o];
|
||
var attr = document.createAttribute('data-ignore-limit');
|
||
attr.value = 'true';
|
||
meta.setAttributeNode(attr);
|
||
document.getElementsByTagName('head')[0].appendChild(meta);
|
||
}
|
||
*/
|
||
|
||
|
||
var __ncbi_sg_pingCallbacks_render_gene = function (data, evtObj, type) {
|
||
// data looks like {jsevent: "click", "link_id": "foo", ...}
|
||
// evtObj is the JS event object
|
||
// type is either "stat" (for applog) or "ga"
|
||
var extraData = {};
|
||
if (type == "stat") {
|
||
for (var o in section_status_meta) {
|
||
extraData[o] = section_status_meta[o];
|
||
}
|
||
|
||
return extraData;
|
||
|
||
}
|
||
}
|
||
|
||
|
||
</script></div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last" id="sidebar_tabular">
|
||
<!-- sidebar close/hide button-->
|
||
<div class="ui-helper-clearfix">
|
||
<a href="#" id="sidecontent_2_pullout" style="float:right;" class="sidecontentpullout_local collapse_button"><span>Hide sidebar >></span></a>
|
||
</div>
|
||
<!-- end sidebar close/hide button-->
|
||
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div id="gene-sidebar">
|
||
<div>
|
||
<div class="portlet brieflink dis-table-of-contents">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Table of contents</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_TableOfContents" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li class="">
|
||
<a href="#summary">Summary</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#genomic-context">Genomic context</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#genomic-regions-transcripts-products">Genomic regions, transcripts, and products</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#bibliography">Bibliography</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#phenotypes">Phenotypes</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#variation">Variation</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#general-gene-info">General gene information</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#reference-sequences">NCBI Reference Sequences (RefSeq)</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#related-sequences">Related sequences</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#additional-links">Additional links</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-genomesbrowser brieflink dis-genomesbrowser">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Genome Browsers</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GenomeBrowsers.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GenomeBrowsers" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GenomeBrowsers.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="#">Loading...</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet dis-related-info brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content DiscoveryDbLinks">
|
||
<ul>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/bioproject?LinkName=gene_bioproject&from_uid=108491823" ref="log$=recordlinks">BioProjects</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioProjects related to a gene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar&from_uid=108491823" ref="log$=recordlinks">ClinVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc&from_uid=108491823" ref="log$=recordlinks">Full text in PMC</a>
|
||
<div class="brieflinkpop offscreen_noflow">PMC links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc_nucleotide&from_uid=108491823" ref="log$=recordlinks">Full text in PMC_nucleotide</a>
|
||
<div class="brieflinkpop offscreen_noflow">Full text in PubMedCentral identified from shared sequence links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gene?LinkName=gene_gene_neighbors&from_uid=108491823" ref="log$=recordlinks">Gene neighbors</a>
|
||
<div class="brieflinkpop offscreen_noflow">Overlapping genes and two nearest non-overlapping genes on either side</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore&from_uid=108491823" ref="log$=recordlinks">Nucleotide</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related Nucleotide entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed&from_uid=108491823" ref="log$=recordlinks">PubMed</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related PubMed entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_pmc_nucleotide&from_uid=108491823" ref="log$=recordlinks">PubMed(nucleotide/PMC)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Citations in PubMed identified from shared sequence and PMC links.</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/taxonomy?LinkName=gene_taxonomy&from_uid=108491823" ref="log$=recordlinks">Taxonomy</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related taxonomy entry</div>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet dis-links-to-other-res brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Links to other resources</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_LinksTwo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=geneid&org=9606&l=108491823">AceView</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-general-info">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>General information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GeneralInfo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="/pmc/?term=PMC4383897+OR+PMC3013746+OR+PMC1761442+OR+PMC539985">About Gene</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK3840">FAQ</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://ftp.ncbi.nlm.nih.gov/gene/">FTP site</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK3841/">Help</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK3842/">My NCBI help</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK21085/">NCBI Handbook</a>
|
||
</li>
|
||
<li>
|
||
<a href="/gene/statistics/">Statistics</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-related-sites">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related sites</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_RelatedSites" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/BLAST">BLAST</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/genome">Genome</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/bioproject">BioProject</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/genome/gdv/">Genome Data Viewer</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/geo">GEO</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/omim">OMIM</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/probe">Probe</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/RefSeq">RefSeq</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-feedback">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Feedback</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_Feedback" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="https://support.ncbi.nlm.nih.gov/ics/support/ticketnewwizard.asp?style=classic&deptID=28049">Contact Help Desk</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/RefSeq/update.cgi?geneid=108491823&symbol=LOC108491823">Submit Correction</a>
|
||
</li>
|
||
<li>
|
||
<a href="/gene/submit-generif?geneId=108491823&sym=LOC108491823&name=CTTNBP2 intron enhancer-blocking element 7-1-1&org=Homo sapiens">Submit GeneRIF</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-subscription">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Subscription</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Subscription.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_Subscription" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Subscription.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/mailman/listinfo/refseq-announce">RefSeq</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<!-- <component id="Gene_RVFullReport.Gene_RightColMenuLinks"/>-->
|
||
<div class="portlet">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Recent activity</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="recent_activity" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<div id="HTDisplay" class="">
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.Cmd" sid="1" type="hidden" />
|
||
<div class="action">
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.ClearHistory" sid="1" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.ClearHistory" cmd="ClearHT" href="?cmd=ClearHT&" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.ClearHistory">
|
||
Clear
|
||
</a>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" sid="1" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOn" cmd="HTOff" href="?cmd=HTOff&" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle">
|
||
Turn Off
|
||
</a>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" sid="2" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOff" cmd="HTOn" href="?cmd=HTOn&" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle">
|
||
Turn On
|
||
</a>
|
||
</div>
|
||
<ul id="activity">
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67d3934dcde49f3df741012b">LOC108491823 [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">LOC108491823 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:108491823</div></div>
|
||
<div class="tertiary">Gene</div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67d3934b2f30673f7b647754">LOC113219474 [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">LOC113219474 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:113219474</div></div>
|
||
<div class="tertiary">Gene</div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67d3934984f3725e59a92392">LOC111674479 [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">LOC111674479 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:111674479</div></div>
|
||
<div class="tertiary">Gene</div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67d39348cde49f3df740dcce">LOC113523647 [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">LOC113523647 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:113523647</div></div>
|
||
<div class="tertiary">Gene</div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67d3934667c23b31e02509a0">LOC111674470 [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">LOC111674470 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:111674470</div></div>
|
||
<div class="tertiary">Gene</div>
|
||
</li>
|
||
</ul>
|
||
<p class="HTOn">Your browsing activity is empty.</p>
|
||
<p class="HTOff">Activity recording is turned off.</p>
|
||
<p id="turnOn" class="HTOff">
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryOn" sid="1" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryOn" cmd="HTOn" href="?cmd=HTOn&" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryOn">Turn recording back on</a>
|
||
</p>
|
||
<a class="seemore" href="/sites/myncbi/recentactivity">See more...</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div id="NCBIFooter_dynamic">
|
||
<!--<component id="NCBIBreadcrumbs"/>
|
||
<component id="NCBIHelpDesk"/>-->
|
||
<noscript><img alt="" src="/stat?jsdisabled=true&ncbi_app=entrez&ncbi_db=gene&ncbi_pdid=full_report&ncbi_phid=CE89DF1B7D37C171000000000066005D" /></noscript>
|
||
</div>
|
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|
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<div xmlns="http://www.w3.org/1999/xhtml" class="footer" id="footer" xml:base="http://127.0.0.1/sites/static/header_footer/">
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||
<section class="icon-section">
|
||
<div id="icon-section-header" class="icon-section_header">Follow NCBI</div>
|
||
<div class="grid-container container">
|
||
<div class="icon-section_container">
|
||
<a class="footer-icon" id="footer_twitter" href="https://twitter.com/ncbi" aria-label="Twitter">
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<svg xmlns="http://www.w3.org/2000/svg" width="40" height="40" viewBox="0 0 40 40" fill="none">
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<title>Twitter</title>
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<g id="twitterx1008">
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<a class="footer-icon" id="footer_facebook" href="https://www.facebook.com/ncbi.nlm" aria-label="Facebook"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
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