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<div class="search"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="pubmed">PubMed</option><option value="clinvar">ClinVar</option><option value="medgen">MedGen</option><option value="books" class="last">Books</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly" data-ac_dict="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene" selected="selected" data-ac_dict="gene">Gene</option><option value="genome" data-ac_dict="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen">MedGen</option><option value="mesh">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore" data-ac_dict="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein" data-ac_dict="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search Gene. Use up and down arrows to choose an item from the autocomplete." value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="dictionary:'gene',disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'yes',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div><ul class="searchlinks inline_list"><set></set><li><a href="/gene/advanced">Advanced</a></li><li class="help"><a id="help" class="jig-ncbihelpwindow" target="ncbihelp" name="help" href="/books/NBK3841/">Help</a></li></ul></div>
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<div class="facet_cont" data-db="gene" data-default_grps="fg_gene-sources,fg_categories,fg_sequence-content,fg_status" data-sd="db:'gene',op:'select',term:'',qk:'3429',linkname:'',idsfromresult:'10410',extra:''"><ul class="facet" data-filter_id="gene-sources" id="_gene-sources"><li class="filter_grp "><div class="clearfix"><h3>Gene sources</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="genomic">Genomic</a></li></ul></li></ul><ul class="facet" data-filter_id="categories" id="_categories"><li class="filter_grp "><div class="clearfix"><h3>Categories</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="alt-splicing">Alternatively spliced</a></li><li class="fil_val"><a href="#" data-value_id="annotated-genes">Annotated genes</a></li><li class="fil_val"><a href="#" data-value_id="gene-type-protein-coding">Protein-coding</a></li></ul></li></ul><ul class="facet" data-filter_id="sequence-content" id="_sequence-content"><li class="filter_grp "><div class="clearfix"><h3>Sequence content</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="seq-ccds">CCDS</a></li><li class="fil_val"><a href="#" data-value_id="seq-ensembl">Ensembl</a></li><li class="fil_val"><a href="#" data-value_id="refseq">RefSeq</a></li><li class="fil_val"><a href="#" data-value_id="seq-refseqgene">RefSeqGene</a></li></ul></li></ul><ul class="facet" data-filter_id="status" id="_status"><li class="filter_grp "><div class="clearfix"><h3>Status</h3><a href="#" data-value_id="" class="clear clear_show">Clear</a></div><ul><li class="fil_val selected"><a href="#" data-value_id="current-only">Current</a><span class="fcount">(1)</span></li></ul></li></ul><div id="chr-location-facet-wrapper" data-bid="MCID_67c9df10d74f676910406eac" data-hid="MCID_67c90f2d64f30b25346ccae2" data-qky="3429" class="disabled" style="display:none"><ul class="facet" data-filter_id="chromosomal-region" id="_chromosomal-region" data-of="yes"><li class="filter_grp of_grp"><div class="clearfix"><h3>Chromosome locations</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><a id="facet_ofchromosomal-region" href="#facet_of_divchromosomal-region" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'middle left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '375px'" data-value_id="fetch_more">more...</a><div id="facet_of_divchromosomal-region" style="display:none;" class="of_popup"><h4>Chromosome locations</h4><label for="organism-filter" style="width:100%;margin-bottom:.2em;" class="">Select an organism by typing or scrolling</label><input type="text" placeholder="Enter text to narrow down the list" id="organism-filter" style="width:98%;" autocomplete="off" /><br /><div id="chr-region-tax-list"><select id="of_chromosomal-region" size="9" class="chr-region-tax-list" style="width:100%;"></select></div><div id="chr-location-info-ctrl" data-disabled="disabled"><div class="chr-field"><label for="chr-name">Chromosome</label><br /><select id="chr-name" class="chr-field" disabled="disabled"></select></div><div class="chr-field"><label for="chr-from">From</label><br /><input type="text" name="chr-from" id="chr-from" disabled="disabled" class="chr-field" /></div><div class="chr-field"><label for="chr-to">To</label><br /><input type="text" name="chr-to" id="chr-to" disabled="disabled" class="chr-field" /></div></div><div class="actions clearfix"><button class="jig-ncbibutton of_add apply-chr" data-jigconfig="'color': 'ui-ncbibutton-blue'">Apply</button></div></div></ul></li></ul></div><ul class="facet facet_reset"><li><a href="#" data-value_id="reset">Clear all</a></li></ul><ul class="facet_tools"><li><a id="more_filter_groups_link" href="#more_filter_groups" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'top left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '180px'">
Show additional filters</a></li><div id="more_filter_groups" style="display:none;" class="facets_dialog"><button class="ui-ncbipopper-close-button ui-ncbipopper-close-button-generated ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-blue" generated="true" role="button" aria-disabled="false"><span class="ui-button-text">x</span></button><h4>Additional filters</h4><ul class="filter_groups_more facet"><li><input type="checkbox" id="fg_gene-sources" /><label for="fg_gene-sources">Gene sources</label></li><li><input type="checkbox" id="fg_categories" /><label for="fg_categories">Categories</label></li><li><input type="checkbox" id="fg_sequence-content" /><label for="fg_sequence-content">Sequence content</label></li><li><input type="checkbox" id="fg_status" /><label for="fg_status">Status</label></li><li><input type="checkbox" id="fg_chromosomal-region" /><label for="fg_chromosomal-region">Chromosome locations</label></li><li><input id="fg_field_search" type="checkbox" /><label for="fg_field_search">Search fields</label></li></ul><div class="actions clearfix"><button class="filter_groups_more_apply jig-ncbibutton primary-action" id="filter_groups_apply" data-jigconfig="'color': 'ui-ncbibutton-blue'">Show</button></div></div></ul><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetsUrlFrag" sid="1" type="hidden" value="filters=current-only" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetSubmitted" sid="1" type="hidden" value="false" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.BMFacets" sid="1" type="hidden" value="" /></div>
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<h1 class="title" id="gene-name"><span class="gn" style="padding-right:.5em;">IFITM3</span> interferon induced transmembrane protein 3 [ <em class="tax">Homo sapiens</em> (human)
]
</h1>
<span class="geneid">Gene ID: 10410, updated on
4-Mar-2025</span>
</div>
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<div class="rprt-section gene-summary">
<section class="rprt-section-header" id="summary">
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<dl id="summaryDl">
<dt class="noline"> Official
Symbol</dt>
<dd class="noline">IFITM3<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
<dt> Official
Full Name</dt>
<dd>interferon induced transmembrane protein 3<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
<dt>Primary source</dt>
<dd>
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5414" data-gblink-text="Ensembl">HGNC:HGNC:5414</a>
</dd>
<dt>See related</dt>
<dd>
<a href="http://www.ensembl.org/id/ENSG00000142089" data-gblink-text="Ensembl" class="genome-browser-link" data-genome-browser-link-sort="5" data-gb-url="http://www.ensembl.org/loc/ENSG00000142089">Ensembl:ENSG00000142089</a>
<a href="https://www.ncbi.nlm.nih.gov/omim/605579" data-gblink-text="Ensembl" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=605579">MIM:605579;</a>
<a href="https://www.alliancegenome.org/gene/HGNC:5414" data-gblink-text="Ensembl" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=HGNC:5414">AllianceGenome:HGNC:5414</a>
</dd>
<dt>Gene type</dt>
<dd>protein coding</dd>
<dt>RefSeq status</dt>
<dd>REVIEWED</dd>
<dt>Organism</dt>
<dd class="tax">
<a href="/Taxonomy/Browser/wwwtax.cgi?id=9606" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=9606">Homo sapiens</a>
</dd>
<dt>Lineage</dt>
<dd class="tax">Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo</dd>
<dt>Also known as</dt>
<dd>1-8U; IP15; DSPA2b</dd>
<dt>Summary</dt>
<dd>Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 and belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021]</dd>
<dt>Annotation information</dt>
<dd>Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.</dd>
<dt>Expression</dt>
<dd>Ubiquitous expression in liver (RPKM 370.9), placenta (RPKM 358.2) and 25 other tissues <a href="#gene-expression">See more</a></dd>
<dt>Orthologs</dt>
<dd class="ortholog-links">
<a href="/gene/10410/ortholog/">all</a>
</dd>
<dt style="padding-top:.5em;">
<span class="new-icon">NEW</span>
</dt>
<dd style="padding-top:.5em;">
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/10410/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="gene_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Gene table</a></strong>
<br />
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/10410/products/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="transcript_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Transcript table</a></strong>
</dd>
</dl>
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<div class="rprt-section gene-genomic-context">
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<div class="gt_cont_contents">
<div style="float:right"><span>See IFITM3 in </span><a href="/genome/gdv/?context=gene&amp;acc=10410" class="link-to-gdv genome-browser-link" data-genome-browser-link-sort="1" data-acc="GCF_000001405.40">Genome Data Viewer</a> </div>
<dl class="dl-chr-info" style="float:left;margin-top:0;">
<dt>Location: </dt>
<dd>
<span style="display:inline-block;">11p15.5</span>
</dd>
</dl>
</div>
<dl class="dl-chr-info exon-count">
<dt>Exon count: </dt>
<dd>2</dd>
</dl>
<div class="ui-ncbigrid-outer-div" id="genomic-context-tbl-location">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="">
<thead>
<tr>
<th style="max-width:15%">Annotation release</th>
<th style="max-width:10%">Status</th>
<th>Assembly</th>
<th>
<span title="Chromosome">Chr</span>
</th>
<th>Location</th>
</tr>
</thead>
<tbody>
<tr>
<td>RS_2024_08</td>
<td>current</td>
<td>GRCh38.p14 (<a href="/assembly/GCF_000001405.40/" ref="ncbi_uid=10410&amp;link_uid=GCF_000001405.40">GCF_000001405.40</a>)</td>
<td>11</td>
<td>NC_000011.10 (319676..320860, complement) </td>
</tr>
<tr>
<td>RS_2024_08</td>
<td>current</td>
<td>T2T-CHM13v2.0 (<a href="/assembly/GCF_009914755.1/" ref="ncbi_uid=10410&amp;link_uid=GCF_009914755.1">GCF_009914755.1</a>)</td>
<td>11</td>
<td>NC_060935.1 (360910..362094, complement) </td>
</tr>
<tr>
<td>RS_2024_09</td>
<td>previous assembly</td>
<td>GRCh37.p13 (<a href="/assembly/GCF_000001405.25/" ref="ncbi_uid=10410&amp;link_uid=GCF_000001405.25">GCF_000001405.25</a>)</td>
<td>11</td>
<td>NC_000011.9 (319676..320860, complement) </td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<p class="withnote margin_t2em"><strong>Chromosome 11 - NC_000011.10</strong><img usemap="#nbrMap10410_568815587" border="0" alt="Genomic Context describing neighboring genes" src="/gutils/geneneighb.fcgi?geneid=10410&amp;nuc_gi=568815587&amp;n0=IFITM2&amp;n1=LOC130005047&amp;n2=LOC130005048&amp;n3=LOC130005049&amp;n4=LOC127819960&amp;n5=LOC127819961&amp;n6=LOC127819962&amp;n7=IFITM1&amp;n8=LOC130005050&amp;n9=LOC130005051&amp;n10=LOC130005052&amp;n11=LOC130005053&amp;n12=LOC130005054&amp;n13=LOC130005055&amp;n14=LOC127819963&amp;n15=LOC130005056&amp;n16=LOC127819964&amp;n17=IFITM3-AS1&amp;n18=LOC127819965&amp;n19=IFITM3&amp;n20=LOC127819966&amp;n21=LOC130005057&amp;n22=LOC130005058&amp;n23=LOC130005059&amp;n24=LOC130005060&amp;n25=LOC127819967&amp;n26=LOC127819968&amp;n27=LOC116216126&amp;n28=LOC130005061&amp;n29=LOC129662839&amp;n30=LOC127819969&amp;n31=LOC127819970&amp;n32=LOC127819971&amp;n33=B4GALNT4&amp;n34=LOC129662840&amp;n35=PKP3&amp;n36=LOC127819972&amp;n37=LOC127819973" /><map name="nbrMap10410_568815587" id="nbrMap10410_568815587">
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 4260')" onMouseOut="hidetip()" coords="3,23,73,31" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4260" href="/gene/130005047" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 4261')" onMouseOut="hidetip()" coords="6,35,76,43" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4261" href="/gene/130005048" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 4262')" onMouseOut="hidetip()" coords="6,47,76,55" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4262" href="/gene/130005049" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:311550-312155')" onMouseOut="hidetip()" coords="16,59,86,67" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:311550-312155" href="/gene/127819960" />
<area shape="rect" onMouseOver="showtip(this,event,'NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:313425-313980')" onMouseOut="hidetip()" coords="23,71,93,79" alt="Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:313425-313980" href="/gene/127819961" />
<area shape="rect" onMouseOver="showtip(this,event,'NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:313981-314536')" onMouseOut="hidetip()" coords="25,83,95,91" alt="Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:313981-314536" href="/gene/127819962" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 4264')" onMouseOut="hidetip()" coords="28,95,98,103" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4264" href="/gene/130005050" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 4265')" onMouseOut="hidetip()" coords="30,107,100,115" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4265" href="/gene/130005051" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 2994')" onMouseOut="hidetip()" coords="31,119,101,127" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2994" href="/gene/130005052" />
<area shape="rect" onMouseOver="showtip(this,event,'interferon induced transmembrane protein 2')" onMouseOut="hidetip()" coords="32,131,72,139" alt="Neighboring gene interferon induced transmembrane protein 2" href="/gene/10581" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 2995')" onMouseOut="hidetip()" coords="32,143,102,151" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2995" href="/gene/130005053" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 2996')" onMouseOut="hidetip()" coords="33,155,103,163" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2996" href="/gene/130005054" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 4266')" onMouseOut="hidetip()" coords="34,167,104,175" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4266" href="/gene/130005055" />
<area shape="rect" onMouseOver="showtip(this,event,'NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:316761-317316')" onMouseOut="hidetip()" coords="35,179,105,187" alt="Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:316761-317316" href="/gene/127819963" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 4267')" onMouseOut="hidetip()" coords="38,191,108,199" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4267" href="/gene/130005056" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:318431-318986')" onMouseOut="hidetip()" coords="41,203,111,211" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:318431-318986" href="/gene/127819964" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:318987-319542')" onMouseOut="hidetip()" coords="43,215,113,223" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:318987-319542" href="/gene/127819965" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:320655-321210')" onMouseOut="hidetip()" coords="49,227,119,235" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:320655-321210" href="/gene/127819966" />
<area shape="rect" onMouseOver="showtip(this,event,'IFITM3 antisense RNA 1')" onMouseOut="hidetip()" coords="51,239,160,247" alt="Neighboring gene IFITM3 antisense RNA 1" href="/gene/105376505" />
<area shape="rect" onMouseOver="showtip(this,event,'interferon induced transmembrane protein 1')" onMouseOut="hidetip()" coords="55,251,95,259" alt="Neighboring gene interferon induced transmembrane protein 1" href="/gene/8519" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 4268')" onMouseOut="hidetip()" coords="71,263,141,271" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4268" href="/gene/130005057" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 4269')" onMouseOut="hidetip()" coords="73,131,143,139" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4269" href="/gene/130005058" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 4270')" onMouseOut="hidetip()" coords="75,23,145,31" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4270" href="/gene/130005059" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 4271')" onMouseOut="hidetip()" coords="88,35,158,43" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4271" href="/gene/130005060" />
<area shape="rect" onMouseOver="showtip(this,event,'NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:333329-333882')" onMouseOut="hidetip()" coords="96,47,166,55" alt="Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:333329-333882" href="/gene/127819967" />
<area shape="rect" onMouseOver="showtip(this,event,'NANOG-H3K27ac hESC enhancer GRCh37_chr11:333883-334436')" onMouseOut="hidetip()" coords="98,59,168,67" alt="Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:333883-334436" href="/gene/127819968" />
<area shape="rect" onMouseOver="showtip(this,event,'CRISPRi-validated cis-regulatory element chr11.30')" onMouseOut="hidetip()" coords="161,23,231,31" alt="Neighboring gene CRISPRi-validated cis-regulatory element chr11.30" href="/gene/116216126" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 4272')" onMouseOut="hidetip()" coords="169,35,239,43" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4272" href="/gene/130005061" />
<area shape="rect" onMouseOver="showtip(this,event,'ReSE screen-validated silencer GRCh37_chr11:353490-353656')" onMouseOut="hidetip()" coords="171,47,241,55" alt="Neighboring gene ReSE screen-validated silencer GRCh37_chr11:353490-353656" href="/gene/129662839" />
<area shape="rect" onMouseOver="showtip(this,event,'NANOG-H3K4me1 hESC enhancer GRCh37_chr11:354319-354895')" onMouseOut="hidetip()" coords="174,59,244,67" alt="Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:354319-354895" href="/gene/127819969" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:355877-356829')" onMouseOut="hidetip()" coords="180,71,250,79" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:355877-356829" href="/gene/127819970" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:368032-368570')" onMouseOut="hidetip()" coords="225,83,295,91" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:368032-368570" href="/gene/127819971" />
<area shape="rect" onMouseOver="showtip(this,event,'beta-1,4-N-acetyl-galactosaminyltransferase 4')" onMouseOut="hidetip()" coords="250,23,339,31" alt="Neighboring gene beta-1,4-N-acetyl-galactosaminyltransferase 4" href="/gene/338707" />
<area shape="rect" onMouseOver="showtip(this,event,'ReSE screen-validated silencer GRCh37_chr11:380111-380268')" onMouseOut="hidetip()" coords="269,35,339,43" alt="Neighboring gene ReSE screen-validated silencer GRCh37_chr11:380111-380268" href="/gene/129662840" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:393662-394424')" onMouseOut="hidetip()" coords="319,47,389,55" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:393662-394424" href="/gene/127819972" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr11:396383-396912')" onMouseOut="hidetip()" coords="329,59,399,67" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:396383-396912" href="/gene/127819973" />
<area shape="rect" onMouseOver="showtip(this,event,'plakophilin 3')" onMouseOut="hidetip()" coords="355,23,423,31" alt="Neighboring gene plakophilin 3" href="/gene/11187" />
</map>
</p>
</div>
</div>
<div class="rprt-section gene-genomic-regions-transcripts-products">
<section class="rprt-section-header" id="genomic-regions-transcripts-products">
<h2 id="header-genomic-regions-transcripts-products">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-regions-transcripts-products .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Genomic regions, transcripts, and products</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Genomic_Regions_Transcripts_a" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<div style="text-align:right;">Go to <a href="#reference-sequences">reference sequence details</a></div>
</div>
<div>
<p class="choose">
<label for="accession" class="label">Genomic Sequence: </label>
<select name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.accessionList" sid="1" id="accessionList" data-taxid="9606" data-geneid="10410">
<option value="NC_000011.10_319675_320859">NC_000011.10 Chromosome 11 Reference GRCh38.p14 Primary Assembly</option>
<option value="NG_032755.1_5054_6238">NG_032755.1 RefSeqGene</option>
<option value="NC_060935.1_360909_362093">NC_060935.1 Chromosome 11 Alternate T2T-CHM13v2.0</option>
<option value="NC_000011.9_319675_320859">NC_000011.9 Chromosome 11 Reference GRCh37.p13 Primary Assembly</option>
</select>
</p>
</div>
<div id="NC_000011" class="divAccession">
<div class="seq-viewer">
<p class="note-link">
<strong>Go to nucleotide:</strong>
<a title="Nucleotide Graphic report" href="/nuccore/NC_000011.10?report=graph&amp;from=319497&amp;to=321037&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=NC_000011.10">Graphics</a>
<a title="Nucleotide FASTA report" href="/nuccore/NC_000011.10?report=fasta&amp;from=319676&amp;to=320860&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=NC_000011.10">FASTA</a>
<a title="Nucleotide GenBank report" href="/nuccore/NC_000011.10?report=genbank&amp;from=319676&amp;to=320860&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=NC_000011.10">GenBank</a>
</p>
<div id="divNC_000011" class="SeqViewerApp" style="clear:both;" data-sv="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000011.10&amp;from=319497&amp;to=321037&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40">
<a href="?appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000011.10&amp;from=319497&amp;to=321037&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40"></a>
</div>
</div>
</div>
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000011.10" sid="1" type="hidden" id="nucleotideLink_NC_000011_10_319675_320859" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_000011.10?report=graph&amp;amp;from=319497&amp;amp;to=321037&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.40&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=10410&amp;amp;link_uid=NC_000011.10&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_000011.10?report=fasta&amp;amp;from=319676&amp;amp;to=320860&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=10410&amp;amp;link_uid=NC_000011.10&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_000011.10?report=genbank&amp;amp;from=319676&amp;amp;to=320860&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=10410&amp;amp;link_uid=NC_000011.10&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000011.10" sid="1" type="hidden" id="relString_NC_000011_10_319675_320859" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_000011.10&amp;amp;from=319497&amp;amp;to=321037&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.40" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NG_032755.1" sid="1" type="hidden" id="nucleotideLink_NG_032755_1_5054_6238" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NG_032755.1?report=graph&amp;amp;from=4876&amp;amp;to=6416&amp;amp;tracks=[key:sequence_track,name:Sequence,display_name:Sequence,category:Sequence,annots:Sequence,ShowLabel:false][key:gene_model_track,name:Genes---Unnamed,display_name:Genes,annots:Unnamed,Options:ShowAllButGenes,SNPs:false,CDSProductFeats:false,ShowLabelsForAllFeatures:true,HighlightMode:2][key:SNP_track,name:SNP,annots:SNP,Layout:Adaptive][key:SNP_Bins_track,name:Clinical Variants][key:SNP_Bins_track,name:Cited Variants][key:GWAS_track,name:GWAS Tracks,display_name:Association Results][key:alignment_track,category:Alignments,annots:Unnamed][key:alignment_track,category:Alignments,annots:NA000079160.1][key:alignment_track,category:Alignments,annots:NA000010065.1]&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=10410&amp;amp;link_uid=NG_032755.1&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NG_032755.1?report=fasta&amp;amp;from=5055&amp;amp;to=6239&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=10410&amp;amp;link_uid=NG_032755.1&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NG_032755.1?report=genbank&amp;amp;from=5055&amp;amp;to=6239&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=10410&amp;amp;link_uid=NG_032755.1&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NG_032755.1" sid="1" type="hidden" id="relString_NG_032755_1_5054_6238" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NG_032755.1&amp;amp;from=4876&amp;amp;to=6416&amp;amp;tracks=[key:sequence_track,name:Sequence,display_name:Sequence,category:Sequence,annots:Sequence,ShowLabel:false][key:gene_model_track,name:Genes---Unnamed,display_name:Genes,annots:Unnamed,Options:ShowAllButGenes,SNPs:false,CDSProductFeats:false,ShowLabelsForAllFeatures:true,HighlightMode:2][key:SNP_track,name:SNP,annots:SNP,Layout:Adaptive][key:SNP_Bins_track,name:Clinical Variants][key:SNP_Bins_track,name:Cited Variants][key:GWAS_track,name:GWAS Tracks,display_name:Association Results][key:alignment_track,category:Alignments,annots:Unnamed][key:alignment_track,category:Alignments,annots:NA000079160.1][key:alignment_track,category:Alignments,annots:NA000010065.1]" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_060935.1" sid="1" type="hidden" id="nucleotideLink_NC_060935_1_360909_362093" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_060935.1?report=graph&amp;amp;from=360731&amp;amp;to=362271&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_009914755.1&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=10410&amp;amp;link_uid=NC_060935.1&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_060935.1?report=fasta&amp;amp;from=360910&amp;amp;to=362094&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=10410&amp;amp;link_uid=NC_060935.1&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_060935.1?report=genbank&amp;amp;from=360910&amp;amp;to=362094&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=10410&amp;amp;link_uid=NC_060935.1&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_060935.1" sid="1" type="hidden" id="relString_NC_060935_1_360909_362093" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_060935.1&amp;amp;from=360731&amp;amp;to=362271&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_009914755.1" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000011.9" sid="1" type="hidden" id="nucleotideLink_NC_000011_9_319675_320859" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_000011.9?report=graph&amp;amp;from=319497&amp;amp;to=321037&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.25&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=10410&amp;amp;link_uid=NC_000011.9&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_000011.9?report=fasta&amp;amp;from=319676&amp;amp;to=320860&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=10410&amp;amp;link_uid=NC_000011.9&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_000011.9?report=genbank&amp;amp;from=319676&amp;amp;to=320860&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=10410&amp;amp;link_uid=NC_000011.9&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000011.9" sid="1" type="hidden" id="relString_NC_000011_9_319675_320859" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_000011.9&amp;amp;from=319497&amp;amp;to=321037&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.25" />
</div>
</div>
<div class="rprt-section gene-gene-expression">
<section class="rprt-section-header" id="gene-expression">
<h2 id="header-gene-expression">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-gene-expression .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Expression</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Expression" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<div style="text-align:right;">
<a href="/gene/10410/?report=expression" data-url="/gene/10410/?report=expression" id="gene-expression-see-details">See details</a>
</div>
<div id="gene-expression-app" data-url="https://www.ncbi.nlm.nih.gov/gene/10410" data-report-type="summary">
<div>
<script type="text/javascript">
window.tissues_data = {'adrenal 10wk': {'id': '10410_Adrenal_10wk_PRJNA270632', 'gene': 10410, 'source_name': 'adrenal 10wk', 'full_rpkm': 9.80952, 'exp_rpkm': 9.81, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734414038204417}, 'adrenal 16wk': {'id': '10410_Adrenal_16wk_PRJNA270632', 'gene': 10410, 'source_name': 'adrenal 16wk', 'full_rpkm': 21.8425, 'exp_rpkm': 21.8, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734414038204418}, 'adrenal 18wk': {'id': '10410_Adrenal_18wk_PRJNA270632', 'gene': 10410, 'source_name': 'adrenal 18wk', 'full_rpkm': 32.4237, 'exp_rpkm': 32.4, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734414038204419}, 'adrenal 20wk': {'id': '10410_Adrenal_20wk_PRJNA270632', 'gene': 10410, 'source_name': 'adrenal 20wk', 'full_rpkm': 25.8718, 'exp_rpkm': 25.9, 'var': 5.04636, 'project_desc': 'PRJNA270632', '_version_': 1785734414038204420}, 'heart 10wk': {'id': '10410_Heart_10wk;_PRJNA270632', 'gene': 10410, 'source_name': 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<option value="SRP051249" selected="selected" data-bioproject="PRJNA270632">
Tissue-specific circular RNA induction during human fetal development
</option>
<option value="SRP056969" data-bioproject="PRJNA280600">
RNA sequencing of total RNA from 20 human tissues
</option>
<option value="ERP003613" data-bioproject="PRJEB4337">
HPA RNA-seq normal tissues
</option>
</select>
<ul id="project-summary">
<li id="project-summary-title">Project title:
Tissue-specific circular RNA induction during human fetal development
</li>
<li id="project-summary-desc">Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA</li>
<li id="project-summary-bioprojects">BioProject: <a href="/bioproject/PRJNA270632/">PRJNA270632</a>
</li>
<li id="project-summary-pubs">Publication:
<span><a href="/pubmed/26076956/">PMID 26076956</a></span>
</li>
<li id="project-summary-analysis-date">Analysis date: Mon Apr 2 22:54:59 2018</li>
</ul>
<div id="gene-expr-details" class="expression-chart"></div>
</div>
</div>
</div>
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<div class="rprt-section gene-bibliography">
<section class="rprt-section-header" id="bibliography"><h2 id="header-bibliography"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-bibliography .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Bibliography</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Bibliography" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
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<h3 id="relatedarticlesinpubmed">
<a href="#" class="jig-ncbitoggler-open">Related articles in PubMed</a>
</h3>
<div class="generefbl-link">
<ol class="generef-link">
<li>
<a href="/pubmed/29202190/" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=29202190">Lack of Truncated IFITM3 Transcripts in Cells Homozygous for the rs12252-C Variant That is Associated With Severe Influenza Infection.</a>
<span class="pubmed-auth-date"> Makvandi-Nejad S, <em>et al</em>. J Infect Dis, 2018 Jan 4. PMID 29202190</span>
</li>
<li>
<a href="/pubmed/27707929/" ref="ordinalpos=2&amp;ncbi_uid=10410&amp;link_uid=27707929">Constitutively Expressed IFITM3 Protein in Human Endothelial Cells Poses an Early Infection Block to Human Influenza Viruses.</a>
<span class="pubmed-auth-date"> Sun X, <em>et al</em>. J Virol, 2016 Dec 15. PMID 27707929, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC5126373/" ref="ordinalpos=0&amp;ncbi_uid=10410&amp;link_uid=PMC5126373">Free PMC Article</a></span></span>
</li>
<li>
<a href="/pubmed/27835870/" ref="ordinalpos=3&amp;ncbi_uid=10410&amp;link_uid=27835870">No role of IFITM3 in brain tumor formation in vivo.</a>
<span class="pubmed-auth-date"> Stankovic ND, <em>et al</em>. Oncotarget, 2016 Dec 27. PMID 27835870, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC5349921/" ref="ordinalpos=0&amp;ncbi_uid=10410&amp;link_uid=PMC5349921">Free PMC Article</a></span></span>
</li>
<li>
<a href="/pubmed/28341742/" ref="ordinalpos=4&amp;ncbi_uid=10410&amp;link_uid=28341742">pH regulation in early endosomes and interferon-inducible transmembrane proteins control avian retrovirus fusion.</a>
<span class="pubmed-auth-date"> Desai TM, <em>et al</em>. J Biol Chem, 2017 May 12. PMID 28341742, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC5427263/" ref="ordinalpos=0&amp;ncbi_uid=10410&amp;link_uid=PMC5427263">Free PMC Article</a></span></span>
</li>
<li>
<a href="/pubmed/28531322/" ref="ordinalpos=5&amp;ncbi_uid=10410&amp;link_uid=28531322">Evaluation of IFITM3 rs12252 Association With Severe Pediatric Influenza Infection.</a>
<span class="pubmed-auth-date"> Randolph AG, <em>et al</em>. J Infect Dis, 2017 Jul 1. PMID 28531322, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC5853450/" ref="ordinalpos=0&amp;ncbi_uid=10410&amp;link_uid=PMC5853450">Free PMC Article</a></span></span>
</li>
</ol>
<p class="see-all-pm">
<a href="/pubmed?LinkName=gene_pubmed&amp;from_uid=10410" title="See all 183 citations in Pubmed">See all (183) citations in PubMed</a>
</p>
</div>
</div>
<div class="generif-pubmed generif">
<h3 id="generifsgenereferencesintofunctions">
<a href="#" class="jig-ncbitoggler-open">GeneRIFs: Gene References Into Functions</a>
</h3>
<div>
<a href="/gene/about-generif" class="whatisthis">What's a GeneRIF?</a>
<div class="generefbl-link">
<ol class="generef-link">
<li class="gene-rif-popper">
<a href="/pubmed/38760017" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=38760017">TYK2, IFITM3, IFNAR2 and OAS3 single-nucleotide polymorphisms among severe COVID-19 ICU patients in Morocco.</a>
<div id="gene-popper1" class="gene-rif-popper">Title: TYK2, IFITM3, IFNAR2 and OAS3 single-nucleotide polymorphisms among severe COVID-19 ICU patients in Morocco.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/38717821" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=38717821">Interferon-Induced Transmembrane Protein-3 Rs12252-G Variant Increases COVID-19 Mortality Potential in Egyptian Population.</a>
<div id="gene-popper2" class="gene-rif-popper">Title: Interferon-Induced Transmembrane Protein-3 Rs12252-G Variant Increases COVID-19 Mortality Potential in Egyptian Population.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/38462163" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=38462163">Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB-dependent IFITM3 expression.</a>
<div id="gene-popper3" class="gene-rif-popper">Title: Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB-dependent IFITM3 expression.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/38402626" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=38402626">IFITM3 inhibits severe fever with thrombocytopenia syndrome virus entry and interacts with viral Gc protein.</a>
<div id="gene-popper4" class="gene-rif-popper">Title: IFITM3 inhibits severe fever with thrombocytopenia syndrome virus entry and interacts with viral Gc protein.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/38400050" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=38400050">Inflammatory Polymorphisms (IL-6 rs1800796, IL-10 rs1800896, TNF-alpha rs1800629, and IFITM3 rs12252) Are Not Associated with Post-COVID Symptoms in Previously Hospitalized COVID-19 Survivors.</a>
<div id="gene-popper5" class="gene-rif-popper">Title: Inflammatory Polymorphisms (IL-6 rs1800796, IL-10 rs1800896, TNF-α rs1800629, and IFITM3 rs12252) Are Not Associated with Post-COVID Symptoms in Previously Hospitalized COVID-19 Survivors.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/38203797" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=38203797">A Knockout of the IFITM3 Gene Increases the Sensitivity of WI-38 VA13 Cells to the Influenza A Virus.</a>
<div id="gene-popper6" class="gene-rif-popper">Title: A Knockout of the IFITM3 Gene Increases the Sensitivity of WI-38 VA13 Cells to the Influenza A Virus.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/38184893" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=38184893">Evaluation of long non-coding RNAs EGOT, NRAV, NRIR and mRNAs ISG15 and IFITM3 expressions in COVID-19 patients.</a>
<div id="gene-popper7" class="gene-rif-popper">Title: Evaluation of long non-coding RNAs EGOT, NRAV, NRIR and mRNAs ISG15 and IFITM3 expressions in COVID-19 patients.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/38140631" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=38140631">IFITM1 and IFITM3 Proteins Inhibit the Infectivity of Progeny HIV-1 without Disrupting Envelope Glycoprotein Clusters.</a>
<div id="gene-popper8" class="gene-rif-popper">Title: IFITM1 and IFITM3 Proteins Inhibit the Infectivity of Progeny HIV-1 without Disrupting Envelope Glycoprotein Clusters.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/38197755" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=38197755">IFITM3-mediated activation of TRAF6/MAPK/AP-1 pathways induces acquired TKI resistance in clear cell renal cell carcinoma.</a>
<div id="gene-popper9" class="gene-rif-popper">Title: IFITM3-mediated activation of TRAF6/MAPK/AP-1 pathways induces acquired TKI resistance in clear cell renal cell carcinoma.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/37055652" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=37055652">Genetic polymorphisms of ACE1, ACE2, IFTM3, TMPRSS2 and TNFalpha genes associated with susceptibility and severity of SARS-CoV-2 infection: a systematic review and meta-analysis.</a>
<div id="gene-popper10" class="gene-rif-popper">Title: Genetic polymorphisms of ACE1, ACE2, IFTM3, TMPRSS2 and TNFα genes associated with susceptibility and severity of SARS-CoV-2 infection: a systematic review and meta-analysis.</div>
</li>
</ol>
</div>
<div class="submit-genrif">
<span>Submit:</span>
<a href="/gene/submit-generif/?geneId=10410&amp;sym=IFITM3&amp;name=interferon induced transmembrane protein 3&amp;org=Homo sapiens">New GeneRIF</a>
<a href="/RefSeq/update.cgi?geneid=10410&amp;symbol=IFITM3;task=fixpub">Correction</a>
<a href="https://www.ncbi.nlm.nih.gov/gene?db=gene&amp;report=generif&amp;term=10410" class="seeall-generif">See all GeneRIFs (139)</a>
</div>
</div>
</div>
</div>
</div>
<div class="rprt-section gene-phenotypes">
<section class="rprt-section-header" id="phenotypes">
<h2 id="header-phenotypes">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-phenotypes .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Phenotypes</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Phenotype" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body info-phenotype">
<p class="nochild-link">
<a href="/gtr/tests/?term=IFITM3[gene]">Find tests for this gene in the NIH Genetic Testing Registry (GTR)</a>
</p>
<p class="nochild-link">
<a href="/gap/PheGenI?tab=1&amp;gene=10410">Review eQTL and phenotype association data in this region using PheGenI</a>
</p>
<div>
<h3 id="associatedconditions">Associated conditions</h3>
<table class="jig-ncbigrid gtr-associated-cond">
<thead>
<tr>
<th class="description">Description</th>
<th>Tests</th>
</tr>
</thead>
<tbody>
<tr>
<td>
<a href="/gtr/conditions/C3553462" ref="ncbi_uid=10410&amp;link_uid=C3553462">Influenza, severe, susceptibility to</a>
<div class="gtr-associated-cond-extra">
<span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C3553462" ref="ncbi_uid=10410&amp;link_uid=C3553462">C3553462</a></span>
<span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/614680" ref="ncbi_uid=10410"> 614680</a></span>
<span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span>
</div>
</td>
<td>
<a href="/gtr/tests/?term=C3553462[DISCUI]&amp;condition=C3553462&amp;compare_labs=1" ref="ncbi_uid=10410">Compare labs</a>
</td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<div class="rprt-section gene-variation">
<section class="rprt-section-header" id="variation">
<h2 id="header-variation">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-variation .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Variation</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.variation" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<p class="nochild-link">
<a href="/clinvar/?term=IFITM3[gene]" ref="log$=recordlinks">See variants in ClinVar</a>
</p>
<p class="nochild-link">
<a href="/dbvar?LinkName=gene_dbvar&amp;from_uid=10410" ref="log$=recordlinks">See studies and variants in dbVar</a>
</p>
<p class="nochild-link">
<a href="/variation/view/?q=10410[geneid]&amp;assm=GCF_000001405.25" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh37.p13)">See Variation Viewer (GRCh37.p13)</a>
</p>
<p class="nochild-link">
<a href="/variation/view/?q=10410[geneid]" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh38)">See Variation Viewer (GRCh38)</a>
</p>
<set></set>
<set></set>
</div>
</div>
<div class="rprt-section gene-HIV-1-interactions">
<section class="rprt-section-header" id="HIV-1-interactions">
<h2 id="header-HIV-1-interactions">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-HIV-1-interactions .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">HIV-1 interactions</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.HIV1_interactions" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div class="fgrid">
<h3 id="replicationinteractions">Replication interactions</h3>
<table summary="replication interactions" class="jig-ncbigrid">
<thead>
<tr>
<th id="hivinter">Interaction</th>
<th id="hivpub">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="hivinter">HIV-1 incorporates IFITM3 into virions but this incorporation does not strictly correlate with the phenotype of IFITM inhibition of HIV-1 cell-to-cell infection</td>
<td headers="hivpub">
<a title="PubMed Id(s): 26387945" href="/pubmed/26387945">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivinter">HIV-1 CXCR4-tropic virus replication is restricted by IFITM2 and IFITM3 as shown through shRNA knockdown</td>
<td headers="hivpub">
<a title="PubMed Id(s): 27640936" href="/pubmed/27640936">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivinter">HIV-1 infectivity is inhibited when IFITM3 is expressed by the virus producing cell (293T cells)</td>
<td headers="hivpub">
<a title="PubMed Id(s): 26387945" href="/pubmed/26387945">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivinter">HIV-1 cell-to-cell transmission (Jurkat-to-Jurkat, 293T-to-Jurkat, PM1 to Jurkat, PBMCs to Jurkat) is inhibited by IFITM3 and this inhibition appears to be regulated by the IFITM protein C terminus, is IFITM-species specific and virus-strain specific</td>
<td headers="hivpub">
<a title="PubMed Id(s): 26387945" href="/pubmed/26387945">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivinter">Knockdown of IFITM1/2/3 by siRNA enhances virus transmission to target cells and the production of virions in CD4+ T cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25464829,25422070" href="/pubmed/25464829,25422070">PubMed</a>
</td>
</tr>
</tbody>
</table>
<h3 id="proteininteractions">Protein interactions</h3>
<table summary="protein interactions" class="jig-ncbigrid">
<thead>
<tr>
<th id="hivprotein">Protein</th>
<th id="gene-hivprotein">Gene</th>
<th id="hivinter">Interaction</th>
<th id="hivpub">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="hivprotein">
<a href="/protein/28876544">Envelope surface glycoprotein gp120</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">HIV-1 gp120 shedding is induced by IFITM3</td>
<td headers="hivpub">
<a title="PubMed Id(s): 26387945" href="/pubmed/26387945">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">HIV-1 gp120 interacts with IFITM3</td>
<td headers="hivpub">
<a title="PubMed Id(s): 26387945" href="/pubmed/26387945">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">HIV-1 Env processing from gp160 to gp120/41 is inhibited by IFITM3</td>
<td headers="hivpub">
<a title="PubMed Id(s): 26387945" href="/pubmed/26387945">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">The exposure to HIV-1 gp120 upregulates the IFITM3 level in HeLa cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24978204" href="/pubmed/24978204">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">Tyrosine kinase Fyn-mediated phosphorylation of IFITM3 at position Y20 induces localization of IFITM3 at the endocytic compartments, which impairs inhibition of Env-mediated entry by IFITM3 delta(1-21) mutant</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24076421,23055554" href="/pubmed/24076421,23055554">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">The expression of IFITM3 delta(1-21) mutant inhibits HIV-1 gp120/gp41 Env-mediated entry into human SupT1 cells, suggesting that the first 21 amino acids in IFITM3 are not required for inhibition of Env-mediated entry</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24076421,23055554" href="/pubmed/24076421,23055554">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/9629363">Envelope surface glycoprotein gp160, precursor</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">HIV-1 gp160 interacts with IFITM3</td>
<td headers="hivpub">
<a title="PubMed Id(s): 26387945" href="/pubmed/26387945">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">IFITM2/3 proteins are co-localize with HIV-1 Env in the cell interior, while surface-associated IFITM2/3 proteins are present at virus budding sites containing HIV-1 Gag and Env proteins in CD4+ T cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25464829" href="/pubmed/25464829">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/19172954">Envelope transmembrane glycoprotein gp41</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">HIV-1 Env processing from gp160 to gp120/41 is inhibited by IFITM3</td>
<td headers="hivpub">
<a title="PubMed Id(s): 26387945" href="/pubmed/26387945">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">HIV-1 gp41 interacts with IFITM3</td>
<td headers="hivpub">
<a title="PubMed Id(s): 26387945" href="/pubmed/26387945">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">Tyrosine kinase Fyn-mediated phosphorylation of IFITM3 at position Y20 induces localization of IFITM3 at the endocytic compartments, which impairs inhibition of Env-mediated entry by IFITM3 delta(1-21) mutant</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24076421,23055554" href="/pubmed/24076421,23055554">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">The expression of IFITM3 delta(1-21) mutant inhibits HIV-1 gp120/gp41 Env-mediated entry into human SupT1 cells, suggesting that the first 21 amino acids in IFITM3 are not required for inhibition of Env-mediated entry</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24076421,23055554" href="/pubmed/24076421,23055554">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/28872818">Nef</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/156110">nef</a>
</td>
<td headers="hivinter">The small molecule PKR inhibitor C16 inhibits the IFITM3-induced suppression of HIV-1 Gag, Vif, and Nef protein expression</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24076421,23376165" href="/pubmed/24076421,23376165">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/156110">nef</a>
</td>
<td headers="hivinter">IFITM3 significantly downregulates the expression of HIV-1 Nef by interfering with Tat/TAR-mediated expression</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24076421,23376165" href="/pubmed/24076421,23376165">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/9629360">Pr55(Gag)</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">IFITM1, IFITM2, and IFITM3 proteins (IFITMs) co-localize with HIV-1 Gag in virus-producing cells and co-assemble with Gag into budding particles</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25422070" href="/pubmed/25422070">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">Endogenous IFITM3 inhibits virus infectivity by measuement of Gag+ target cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25464829,25422070" href="/pubmed/25464829,25422070">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">Endogenous IFITM1/2/3 proteins are upregulated in activated CD4+ T cells and incorporated into HIV-1 Gag/p24-associated virions during infection</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25464829,25422070" href="/pubmed/25464829,25422070">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">IFITM2/3 proteins are co-localize with HIV-1 Env in the cell interior, while surface-associated IFITM2/3 proteins are present at virus budding sites containing HIV-1 Gag and Env proteins in CD4+ T cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25464829" href="/pubmed/25464829">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">The small molecule PKR inhibitor C16 inhibits the IFITM3-induced suppression of HIV-1 Gag, Vif, and Nef protein expression</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24076421,23376165" href="/pubmed/24076421,23376165">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">IFITM3 significantly downregulates the expression of HIV-1 Gag and CA by interfering with both Rev/RRE- and Tat/TAR-mediated expression</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24076421,23376165" href="/pubmed/24076421,23376165">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/9629361">Vif</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155459">vif</a>
</td>
<td headers="hivinter">The small molecule PKR inhibitor C16 inhibits the IFITM3-induced suppression of HIV-1 Gag, Vif, and Nef protein expression</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24076421,23376165" href="/pubmed/24076421,23376165">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155459">vif</a>
</td>
<td headers="hivinter">IFITM3 significantly downregulates the expression of HIV-1 Vif by interfering with both Rev/RRE- and Tat/TAR-mediated expression</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24076421,23376165" href="/pubmed/24076421,23376165">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/28872817">Vpr</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155807">vpr</a>
</td>
<td headers="hivinter">HIV-1 Vpr upregulates the gene expression of IFITM3 in human monocyte-derived dendritic cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 26116899" href="/pubmed/26116899">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155807">vpr</a>
</td>
<td headers="hivinter">IFITM1, 2 or 3 marginally inhibit the entry of HIV-1 NL4-3 and SIV Mac into TZM-bl by measuring the cleavage of CCF2 by BlaM-Vpr that enters the cytoplasm together with viral cores</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25463599" href="/pubmed/25463599">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/19172948">capsid</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">IFITM1, IFITM2, and IFITM3 proteins (IFITMs) co-localize with HIV-1 CA in velocity gradients, indicating that IFITMs are virion-associated proteins</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25422070" href="/pubmed/25422070">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">Endogenous IFITM1/2/3 proteins are upregulated in activated CD4+ T cells and incorporated into HIV-1 Gag/p24-associated virions during infection</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25464829,25422070" href="/pubmed/25464829,25422070">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">IFITM3 significantly downregulates the expression of HIV-1 Gag and CA by interfering with both Rev/RRE- and Tat/TAR-mediated expression</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24076421,23376165" href="/pubmed/24076421,23376165">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/28876542">matrix</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">IFITM3 associates with HIV-1 viral membrane-associated MA rather than with the core in virions</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25464829" href="/pubmed/25464829">PubMed</a>
</td>
</tr>
</tbody>
</table>
<p class="withnote">
<a class="note" href="/genome/viruses/retroviruses/hiv-1/interactions/">Go to the HIV-1, Human Interaction Database </a>
</p>
</div>
</div>
</div>
<div class="rprt-section gene-pathways">
<section class="rprt-section-header" id="pathways">
<h2 id="header-pathways">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-pathways .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Pathways from PubChem</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<ul class="geneinfo-subsec infopathway">
<iframe title="Pathways in which the gene target is involved" class="pubchem-widget" scrolling="no" src="https://pubchem.ncbi.nlm.nih.gov/gene/10410#section=Pathways&amp;embed=true&amp;hide_all_headings=true&amp;page_size=25" style="border: 0; width: 100%;"></iframe>
<script type="text/javascript" src="https://pubchem.ncbi.nlm.nih.gov/pcfe/libs/iframeResizer.min.js"></script>
<script type="text/javascript">iFrameResize({log: false, checkOrigin: false}, '.pubchem-widget')</script>
</ul>
</div>
</div>
<div class="rprt-section gene-interactions">
<section class="rprt-section-header" id="interactions">
<h2 id="header-interactions">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-interactions .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Interactions</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Interactions" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<table summary="Gene Interaction" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/10410/data/interaction/',webserviceParams: 'p$l=Ajax&amp;p$debugoutput=off', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
<thead>
<tr>
<th id="inter-prod">Products</th>
<th id="inter-interactant">Interactant</th>
<th id="inter-otherGene">Other Gene</th>
<th id="inter-compl">Complex</th>
<th id="inter-source">Source</th>
<th id="inter-pubs">Pubs</th>
<th id="inter-desc">Description</th>
</tr>
</thead>
<tbody></tbody>
</table>
</div>
</div>
<div class="rprt-section gene-general-gene-info">
<section class="rprt-section-header" id="general-gene-info">
<h2 id="header-general-gene-info">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-gene-info .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">General gene information</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.General_Gene_Information" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body" style="">
<div id="gene-markers">
<h3 id="markers">
<a class="jig-ncbitoggler">Markers</a>
</h3>
<div>
<ul class="marker odd">
<li class="marker">SGC31615 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=18300%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=18300">UniSTS:18300</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">PMC135632P3 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=270760%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=270760">UniSTS:270760</a></li></ul></li>
</ul>
</div>
</div>
<div>
<div class="infosec" id="Relatedpseudogenes"><h3 id="relatedpseudogenes"><a class="jig-ncbitoggler-open">Related pseudogene(s)</a></h3>
<dl class="geneinfo-subsec"><dt>7 found
 
<a href="/gene/?Term=related_functional_gene_10410%5Bgroup%5D">Review record(s) in Gene</a></dt></dl>
</div>
</div>
<div class="infosec">
<h3 id="homology">
<a class="jig-ncbitoggler-open">Homology</a>
</h3>
<ul class="geneinfo-subsec">
<li>
<a href="/gene/10410/ortholog/" id="ncbi-ortholog-link">NCBI Orthologs</a>
</li>
<a href="https://www.orthodb.org/?ncbi=10410" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8178" target="_blank">
Orthologs from OrthoDB
</a>
</ul>
</div>
<!--<component id="Gene_InfoPathway"/>-->
<div class="gene-ontology infosec">
<h3 id="gene-ontology">
<a class="jig-ncbitoggler-open">
<span>Gene Ontology</span>
</a>
<a target="_blank" href="http://www.ebi.ac.uk/GOA" class="g-ontology-src" title="Provided by GOA">Provided by GOA</a>
</h3>
<div class="ontology-tables">
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Function</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005515">enables protein binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-1-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/18486613,30983867,32296183,33961781" target="_blank" title="PubMed ID 18486613,30983867,32296183,33961781" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=18486613,30983867,32296183,33961781">PubMed</a> </td>
</tr>
</tbody>
</table>
</div>
</div>
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Process</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0051607">involved_in defense response to virus</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-1-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0051607">involved_in defense response to virus</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-2-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/21478870" target="_blank" title="PubMed ID 21478870" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=21478870">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0046597">involved_in host-mediated suppression of symbiont invasion</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-3-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0046597">involved_in host-mediated suppression of symbiont invasion</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-4-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/20943977,21253575,26354436" target="_blank" title="PubMed ID 20943977,21253575,26354436" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=20943977,21253575,26354436">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0046597">involved_in host-mediated suppression of symbiont invasion</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-5-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/23358889" target="_blank" title="PubMed ID 23358889" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=23358889">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0006955">involved_in immune response</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-6-1" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/1906403" target="_blank" title="PubMed ID 1906403" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=1906403">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0045071">involved_in negative regulation of viral genome replication</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-7-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0045071">involved_in negative regulation of viral genome replication</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-8-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/20943977,21253575" target="_blank" title="PubMed ID 20943977,21253575" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=20943977,21253575">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0032897">involved_in negative regulation of viral transcription</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-9-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/20943977" target="_blank" title="PubMed ID 20943977" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=20943977">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0035455">involved_in response to interferon-alpha</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-10-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0035455">involved_in response to interferon-alpha</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-11-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/22479637" target="_blank" title="PubMed ID 22479637" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=22479637">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0035456">involved_in response to interferon-beta</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-12-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-12-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0035456">involved_in response to interferon-beta</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-13-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-13-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/21253575" target="_blank" title="PubMed ID 21253575" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=21253575">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0034341">involved_in response to type II interferon</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-14-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-14-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0034341">involved_in response to type II interferon</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-15-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-15-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/21253575" target="_blank" title="PubMed ID 21253575" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=21253575">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0009615">involved_in response to virus</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-16-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-16-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/20943977,21253575,22479637" target="_blank" title="PubMed ID 20943977,21253575,22479637" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=20943977,21253575,22479637">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0060337">involved_in type I interferon-mediated signaling pathway</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-17-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-17-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
</tbody>
</table>
</div>
</div>
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-config="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Component</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0031901">located_in early endosome membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-1-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/26354436" target="_blank" title="PubMed ID 26354436" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=26354436">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0031902">located_in late endosome membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-2-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005765">located_in lysosomal membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-3-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/26354436" target="_blank" title="PubMed ID 26354436" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=26354436">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0048471">located_in perinuclear region of cytoplasm</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-4-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005886">is_active_in plasma membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-5-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005886">located_in plasma membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-6-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/20943977" target="_blank" title="PubMed ID 20943977" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=20943977">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005886">located_in plasma membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-7-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0032991">part_of protein-containing complex</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-8-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/28246125" target="_blank" title="PubMed ID 28246125" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=28246125">PubMed</a> </td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
</div>
</div>
</div>
<div class="rprt-section gene-general-protein-info">
<section class="rprt-section-header" id="general-protein-info">
<h2 id="header-general-protein-info">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-protein-info .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">General protein information</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.General_Protein_Information" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<dl>
<dt>Preferred Names</dt>
<dd>interferon-induced transmembrane protein 3</dd>
</dl>
<dl>
<dt>Names</dt>
<dd>dispanin subfamily A member 2b</dd>
<dd>interferon-inducible protein 1-8U</dd>
</dl>
</div>
</div>
<div class="rprt-section gene-reference-sequences">
<section class="rprt-section-header" id="reference-sequences">
<h2 id="header-reference-sequences">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-reference-sequences .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">NCBI Reference Sequences (RefSeq)</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.NCBI_Reference_Sequences_RefS" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<p>
<span class="new-icon">NEW</span>
<strong>Try the new <a href="/datasets/tables/genes/?table_type=transcripts&amp;ids=10410&amp;utm_source=gene&amp;utm_medium=referral&amp;utm_campaign=refseq" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report." data-ga-category="refseq" data-ga-action="click_datasets_link" data-ga-label="transcript_table">Transcript table</a></strong>
</p>
<h3 class="genomerefseqs gene_std_toggler" id="refseqset-independent">
<a class="jig-ncbitoggler-open">RefSeqs maintained independently of Annotated
Genomes</a>
</h3>
<div class="genomerefseqs_slave">
<p class="desc"> These reference sequences exist independently of genome builds. <a href="#refseq-expl" id="expl-refseg">Explain</a></p>
<p id="refseq-expl"> These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in <a href="#geneGenomic regions, transcripts, and products">Genomic regions,
transcripts, and products</a> above. </p>
<h4 id="genomic-p11937104">Genomic </h4>
<ol>
<li>
<p>NG_032755.1 RefSeqGene</p>
<dl>
<dt>Range</dt>
<dd class="rs-range">
<span>5055..6239</span>
</dd>
<dt>Download</dt>
<dd><a href="/nuccore/NG_032755.1?from=5055&amp;to=6239&amp;report=genbank" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=NG_032755.1?from=5055&amp;to=6239&amp;report=genbank">GenBank</a>, <a href="/nuccore/NG_032755.1?from=5055&amp;to=6239&amp;report=fasta" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=NG_032755.1?from=5055&amp;to=6239&amp;report=fasta">FASTA</a>, <a href="/nuccore/NG_032755.1?from=4876&amp;to=6416&amp;report=graph&amp;content=5" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=NG_032755.1?from=4876&amp;to=6416&amp;report=graph&amp;content=5">Sequence Viewer (Graphics)</a></dd>
</dl>
</li>
</ol>
<h4 id="mrnaandproteins-p5672336">mRNA and Protein(s) </h4>
<ol>
<li>
<p><a href="/nuccore/NM_021034.3">NM_021034.3</a><a href="/protein/NP_066362.2">NP_066362.2</a>  interferon-induced transmembrane protein 3</p>
<p>
<a href="/ipg/NP_066362.2/" ref="ncbi_uid=10410">See identical proteins and their annotated locations for NP_066362.2</a>
</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Description</dt>
<dd>Transcript Variant: This variant (1) represents the longer, protein-coding transcript.</dd>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AI355192, DB261103">AI355192, DB261103</a>
</dd>
<dt>Consensus CDS</dt>
<dd>
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&amp;GO=MainBrowse&amp;DATA=CCDS41585.1">CCDS41585.1</a>
</dd>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/Q01628" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=10410&amp;nlmid=&amp;db=gene">Q01628</a>, <a href="https://www.uniprot.org/uniprot/Q53Y76" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=10410&amp;nlmid=&amp;db=gene">Q53Y76</a>, <a href="https://www.uniprot.org/uniprot/Q96HK8" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=10410&amp;nlmid=&amp;db=gene">Q96HK8</a>, <a href="https://www.uniprot.org/uniprot/Q96J15" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=10410&amp;nlmid=&amp;db=gene">Q96J15</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/H9NL19" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=10410&amp;nlmid=&amp;db=gene">H9NL19</a>
</dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000382707.4" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=10410&amp;nlmid=&amp;db=gene">ENSP00000382707.4</a>, <a href="http://www.ensembl.org/id/ENST00000399808.5" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=10410&amp;nlmid=&amp;db=gene">ENST00000399808.5</a></dd>
<dt class="clear"> Conserved Domains (1) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_066362.2">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=398284">pfam04505</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">55</span><span class="cddto">121</span></dt>
<dd class="clearfix"> CD225; Interferon-induced transmembrane protein</dd>
</dl>
</dd>
</dl>
</li>
</ol>
<h4 id="rna-p79047744">RNA</h4>
<ol>
<li>
<p><a href="/nuccore/NR_049759.2">NR_049759.2</a> RNA Sequence </p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Description</dt>
<dd>Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of a coding exon compared to variant 1, that causes a frameshift. The resulting transcript is not thought to be protein-coding.</dd>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/BQ937265, DB261103">BQ937265, DB261103</a>
</dd>
<dt>Related</dt>
<dd>
<a href="http://www.ensembl.org/id/ENST00000679382.1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=10410&amp;nlmid=&amp;db=gene">ENST00000679382.1</a>
</dd>
</dl>
</li>
</ol>
</div>
<h3 class="genomerefseqs gene_std_toggler" id="annotatedrefseq-title">
<a class="jig-ncbitoggler-open">RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08</a>
</h3>
<div class="genomerefseqs_slave">
<p class="desc"> The following sections contain reference sequences that belong to a
specific genome build. <a href="#" id="expl-genomes">Explain</a></p>
<p id="expl-genomes-desc" style="display:none">This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.</p>
<h3 id="refseq-sequencedescription-p83243760">Reference GRCh38.p14 Primary Assembly</h3>
<h4 id="genomic-p83243760">Genomic </h4>
<ol>
<li>
<p>NC_000011.10 Reference GRCh38.p14 Primary Assembly</p>
<dl>
<dt>Range</dt>
<dd class="rs-range">
<span>319676..320860 complement</span>
</dd>
<dt>Download</dt>
<dd><a href="/nuccore/NC_000011.10?from=319676&amp;to=320860&amp;report=genbank&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=NC_000011.10?from=319676&amp;to=320860&amp;report=genbank&amp;strand=true">GenBank</a>, <a href="/nuccore/NC_000011.10?from=319676&amp;to=320860&amp;report=fasta&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=NC_000011.10?from=319676&amp;to=320860&amp;report=fasta&amp;strand=true">FASTA</a>, <a href="/nuccore/NC_000011.10?from=319497&amp;to=321037&amp;report=graph&amp;content=5&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=NC_000011.10?from=319497&amp;to=321037&amp;report=graph&amp;content=5&amp;strand=true">Sequence Viewer (Graphics)</a></dd>
</dl>
</li>
</ol>
<h3 id="refseq-sequencedescription-p80895024">Alternate T2T-CHM13v2.0</h3>
<h4 id="genomic-p80895024">Genomic </h4>
<ol>
<li>
<p>NC_060935.1 Alternate T2T-CHM13v2.0</p>
<dl>
<dt>Range</dt>
<dd class="rs-range">
<span>360910..362094 complement</span>
</dd>
<dt>Download</dt>
<dd><a href="/nuccore/NC_060935.1?from=360910&amp;to=362094&amp;report=genbank&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=NC_060935.1?from=360910&amp;to=362094&amp;report=genbank&amp;strand=true">GenBank</a>, <a href="/nuccore/NC_060935.1?from=360910&amp;to=362094&amp;report=fasta&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=NC_060935.1?from=360910&amp;to=362094&amp;report=fasta&amp;strand=true">FASTA</a>, <a href="/nuccore/NC_060935.1?from=360731&amp;to=362271&amp;report=graph&amp;content=5&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=NC_060935.1?from=360731&amp;to=362271&amp;report=graph&amp;content=5&amp;strand=true">Sequence Viewer (Graphics)</a></dd>
</dl>
</li>
</ol>
</div>
</div>
</div>
<div class="rprt-section gene-related-sequences">
<section class="rprt-section-header" id="related-sequences">
<h2 id="header-related-sequences">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-related-sequences .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Related sequences</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Related_Sequences" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<table id="proteinTblId" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/10410/data/related-sequences/',webserviceParams: 'p$l=Ajax', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
<thead>
<tr>
<th colspan="2" id="rs-nucleo">Nucleotide</th>
<th rowspan="2" id="rs-protein">Protein</th>
</tr>
<tr>
<th id="rs-heading">Heading</th>
<th id="rs-heading-acc">Accession and Version</th>
</tr>
</thead>
<tbody></tbody>
</table>
<table id="proteinTblId" class="jig-ncbigrid" data-jigconfig="isPageable:true, pageSize:25">
<thead>
<tr>
<th class="proteinTblTh" rowspan="2" id="rs-prot-acc">Protein Accession</th>
<th class="proteinTblTh" colspan="2" id="rs-link">Links</th>
</tr>
<tr>
<th id="rs-genepept">GenPept Link</th>
<th id="rs-uniprot">UniProtKB Link</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="rs-prot-acc">Q01628.2</td>
<td headers="rs-link rs-genepept">
<a href="/protein/20178301" ref="ordinalpos=1&amp;ncbi_uid=10410&amp;link_uid=20178301">GenPept</a>
</td>
<td>
<a href="https://www.uniprot.org/uniprot/Q01628">UniProtKB/Swiss-Prot:Q01628</a>
</td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<div class="rprt-section gene-additional-links">
<section class="rprt-section-header" id="additional-links"><h2 id="header-additional-links"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-additional-links .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Additional links</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Additional_Links" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
<div class="rprt-section-body" style="">
<h3 class="withnote" id="genelinkout">
<a class="jig-ncbitoggler">Gene LinkOut</a>
</h3><div>
<p>The following <a href="https://www.ncbi.nlm.nih.gov/projects/linkout/index.html">LinkOut</a> resources are supplied by external providers. These providers are responsible for maintaining the links. </p>
<div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Chemical Information</span>
</a>
<ul>
<li><span class="free-rsc"></span>Interologous Interaction Database</li>
<ul>
<li>
<a target="_blank" href="http://ophid.utoronto.ca/redirect/ncbi/human?proteins=10410" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7911">
<span>Interologous Interaction Database</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>MilliporeSigma</li>
<ul>
<li>
<a target="_blank" href="https://www.sigmaaldrich.com/catalog/genes/IFITM3?lang=en&amp;region=US" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9978">
<span>Ifitm3 products</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Molecular Biology Databases</span>
</a>
<ul>
<li><span class="free-rsc"></span>Bgee database</li>
<ul>
<li>
<a target="_blank" href="https://www.bgee.org/gene/ENSG00000142089" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10418">
<span>IFITM3 gene expression</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>BioGPS</li>
<ul>
<li>
<a target="_blank" href="http://biogps.org/gene/10410/" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5059">
<span>BioGPS</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>BioGRID Open Repository of CRISPR Screens (ORCS)</li>
<ul>
<li>
<a target="_blank" href="https://orcs.thebiogrid.org/Gene/10410" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10164">
<span>BioGRID CRISPR Screen Phenotypes (672 hits/1335 screens)</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>CTD: Comparative Toxicogenomics Database</li>
<ul>
<li>
<a target="_blank" href="http://ctdbase.org/detail.go?type=gene&amp;acc=10410" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7845">
<span>CTD: Comparative Toxicogenomics Database - IFITM3</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Domain Mapping of Disease Mutations</li>
<ul>
<li>
<a target="_blank" href="http://bioinf.umbc.edu/DMDM/gene_prot_page.php?id=10410" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7642">
<span>IFITM3</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Eukaryotic Promoter Database</li>
<ul>
<li>
<a target="_blank" href="http://epd.vital-it.ch/cgi-bin/get_doc?db=hgEpdNew&amp;format=genome&amp;entry=IFITM3_1" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9624">
<span>IFITM3_1</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>GlyGen glycoinformatics resource</li>
<ul>
<li>
<a target="_blank" href="https://glygen.org/protein/Q01628" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10227">
<span>GlyGen glycoinformatics resource</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Human eFP Browser</li>
<ul>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Nervous&amp;modeInput=Absolute&amp;primaryGene=10410" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Skeletal_Immune_Digestive&amp;modeInput=Absolute&amp;primaryGene=10410" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Circulatory_Respiratory&amp;modeInput=Absolute&amp;primaryGene=10410" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
</ul>
<li>Ingenuity Pathways Analysis</li>
<ul>
<li>
<a target="_blank" href="http://partnersolution.ingenuity.com/?cid=97ae3f91eab87a&amp;p1=Entrez&amp;p2=GV&amp;s=&amp;ipaUri=%2Fpa%2Fapi%2Fv2%2Fgeneview%3Fapplicationname%3DEntrez%26geneId%3D10410%26geneidtype%3Dentrezgene" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5628">
<span>Ingenuity Pathways Analysis</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>InnateDB</li>
<ul>
<li>
<a target="_blank" href="http://www.innatedb.com/getGeneCard.do?id=16268" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7894">
<span>InnateDB</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>InterMine</li>
<ul>
<li>
<a target="_blank" href="https://www.humanmine.org/humanmine/search?keyword=ENSG00000142089" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9169">
<span>InterMine</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Kyoto Encyclopedia of Genes and Genomes</li>
<ul>
<li>
<a target="_blank" href="http://www.genome.jp/dbget-bin/www_bget?hsa:10410" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5174">
<span>Kyoto Encyclopedia of Genes and Genomes</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>OMA Browser: Orthologous MAtrix</li>
<ul>
<li>
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN03573/" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9822">
<span>OMA Browser: Orthologous MAtrix</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>OrthoDB catalog of orthologs</li>
<ul>
<li>
<a target="_blank" href="https://www.orthodb.org/?ncbi=10410" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8178">
<span>Orthologs</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Pharmacogenomics Knowledge Base</li>
<ul>
<li>
<a target="_blank" href="https://www.pharmgkb.org/gene/PA29655" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=4067">
<span>Annotated Pharmacogenomic Information for IFITM3 [PharmGKB]</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>PhosphoSitePlus</li>
<ul>
<li>
<a target="_blank" href="https://www.phosphosite.org/entrezGeneIdAction.action?id=10410" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7987">
<span>PhosphoSitePlus® - comprehensive post-translational modification resource</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>The Gene Wiki</li>
<ul>
<li>
<a target="_blank" href="https://en.wikipedia.org/wiki/IFITM3" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=6933">
<span>The Gene Wiki</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>The Weizmann Institute of Science GeneCards and MalaCards databases</li>
<ul>
<li>
<a target="_blank" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=IFITM3" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8598">
<span>GeneCard for IFITM3</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Research Materials</span>
</a>
<ul>
<li><span class="order-rsc"></span>Addgene Non-profit plasmid repository</li>
<ul>
<li>
<a target="_blank" href="https://addgene.org//browse/gene/10410" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5304">
<span>Get Plasmids - Addgene</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>Bio-Techne</li>
<ul>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/ifitm3-fragilis/lysates?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=lysates" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>IFITM3/Fragilis Lysates</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/ifitm3-fragilis/antibodies?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=antibodies" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>IFITM3/Fragilis Antibodies</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/ifitm3-fragilis/proteins-enzymes?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=proteins" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>IFITM3/Fragilis Proteins</span>
</a>
</li>
</ul>
<li>ExactAntigen/Labome</li>
<ul>
<li>
<a target="_blank" href="https://www.labome.com/review/gene/human/IFITM3-antibody.html" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5753">
<span>reagent review</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.labome.com/gene/human/IFITM3-antibody.html" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5753">
<span>reagents</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GenScript latest version of gene cDNA ORF Clone</li>
<ul>
<li>
<a target="_blank" href="http://www.genscript.com/gene/10410" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8012">
<span>GenScript latest version of gene cDNA ORF Clone</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GeneCopoeia Inc.</li>
<ul>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=26&amp;field=5&amp;key=10410" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order TALEN/CRISPR clones</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?tax_id=9606&amp;field=5&amp;prt=16&amp;key=10410" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order miRNA target clones</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=1&amp;field=5&amp;key=10410" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order full-length ORF clone</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GeneTex Inc</li>
<ul>
<li>
<a target="_blank" href="https://www.genetex.com/Product/Search?geneid=10410&amp;type=01&amp;page=1" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8117">
<span>Find Quality Antibodies</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.genetex.com/Product/Search?geneid=10410&amp;type=03&amp;page=1" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8117">
<span>Find Recombinant Proteins and Peptides</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>Kazusa DNA Research Institute</li>
<ul>
<li>
<a target="_blank" href="http://www.kazusa.or.jp/kop/dsearch/symsearch.cgi?keyword=IFITM3;" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=3267">
<span>Kazusa DNA Research Institute</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>OriGene</li>
<ul>
<li>
<a target="_blank" href="https://www.origene.com/search?q=Ifitm3" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7994">
<span>Order Ifitm3 cDNA clone/Protein/Antibody/RNAi</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Tools</span>
</a>
<ul>
<li><span class="free-rsc"></span>GeneMANIA</li>
<ul>
<li>
<a target="_blank" href="http://genemania.org/link?o=9606&amp;g=10410" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7529">
<span>GeneMANIA</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open">
<span>Miscellaneous</span>
</a>
<ul>
<li><span class="free-rsc"></span>Reactome</li>
<ul>
<li>
<a target="_blank" href="https://reactome.org/content/query?q=UniProt:Q01628" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=4914">
<span>Reactome Entity:Q01628</span>
</a>
</li>
<li>
<a target="_blank" href="https://reactome.org/PathwayBrowser/#/R-HSA-168256" ref="itool=Gene_FullReport&amp;uid=10410&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=4914">
<span>Reactome Event:Immune System</span>
</a>
</li>
</ul>
</ul>
</div>
</div>
</div>
<div id="urls-in-genombrowser" style="display:none">
</div>
</div>
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<h2 class="offscreen_noflow">Supplemental Content</h2>
<div id="gene-sidebar">
<div>
<div class="portlet brieflink dis-table-of-contents">
<div class="portlet_head">
<div class="portlet_title">
<h3>Table of contents</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_TableOfContents" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li class="">
<a href="#summary">Summary</a>
</li>
<li class="">
<a href="#genomic-context">Genomic context</a>
</li>
<li class="">
<a href="#genomic-regions-transcripts-products">Genomic regions, transcripts, and products</a>
</li>
<li class="">
<a href="#gene-expression">Expression</a>
</li>
<li class="">
<a href="#bibliography">Bibliography</a>
</li>
<li class="">
<a href="#phenotypes">Phenotypes</a>
</li>
<li class="">
<a href="#variation">Variation</a>
</li>
<li class="">
<a href="#HIV-1-interactions">HIV-1 interactions</a>
</li>
<li class="">
<a href="#pathways">Pathways from PubChem</a>
</li>
<li class="">
<a href="#interactions">Interactions</a>
</li>
<li class="">
<a href="#general-gene-info">General gene information</a>
<div class="subsection-links"><a href="#gene-markers">Markers</a>, <a href="#Relatedpseudogenes">Related pseudogene(s)</a>, <a href="#homology">Homology</a>, <a href="#gene-ontology">Gene Ontology</a></div>
</li>
<li class="">
<a href="#general-protein-info">General protein information</a>
</li>
<li class="">
<a href="#reference-sequences">NCBI Reference Sequences (RefSeq)</a>
</li>
<li class="">
<a href="#related-sequences">Related sequences</a>
</li>
<li class="">
<a href="#additional-links">Additional links</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-genomesbrowser brieflink dis-genomesbrowser">
<div class="portlet_head">
<div class="portlet_title">
<h3>Genome Browsers</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GenomeBrowsers.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GenomeBrowsers" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GenomeBrowsers.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="#">Loading...</a>
</li>
</ul>
</div>
</div>
<div class="portlet dis-related-info brieflink">
<div class="portlet_head">
<div class="portlet_title">
<h3>Related information</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter"></a>
</div>
<div class="portlet_content DiscoveryDbLinks">
<ul>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clone/order/gene/10410" ref="log$=recordlinks">Order cDNA clone</a>
<div class="brieflinkpop offscreen_noflow">Order cDNA clone</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_alltarget_list&amp;from_uid=10410" ref="log$=recordlinks">BioAssay by Target (List)</a>
<div class="brieflinkpop offscreen_noflow">BioAssays related to the gene by protein target or RNAi target</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="//pubchem.ncbi.nlm.nih.gov/assay/bioactivity.html?geneid=10410" ref="log$=recordlinks">BioAssay by Target (Summary)</a>
<div class="brieflinkpop offscreen_noflow">Summarized PubChem Data on the gene, showing the active data by default</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_target&amp;from_uid=10410" ref="log$=recordlinks">BioAssay, by Gene target</a>
<div class="brieflinkpop offscreen_noflow">PubChem BioAssays done on the Gene target</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai_active&amp;from_uid=10410" ref="log$=recordlinks">BioAssays, RNAi Target, Active</a>
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent, which is identified as a hit in a RNAi screening and flagged as "active" in the corresponding BioAssay record</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai&amp;from_uid=10410" ref="log$=recordlinks">BioAssays, RNAi Target, Tested</a>
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/bioproject?LinkName=gene_bioproject&amp;from_uid=10410" ref="log$=recordlinks">BioProjects</a>
<div class="brieflinkpop offscreen_noflow">BioProjects related to a gene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/biosystems?LinkName=gene_biosystems&amp;from_uid=10410" ref="log$=recordlinks">BioSystems</a>
<div class="brieflinkpop offscreen_noflow">BioSystems</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/CCDS/CcdsBrowse.cgi?REQUEST=GENEID&amp;DATA=10410" ref="log$=recordlinks">CCDS</a>
<div class="brieflinkpop offscreen_noflow">Link to CCDS</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar&amp;from_uid=10410" ref="log$=recordlinks">ClinVar</a>
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/cdd?LinkName=gene_cdd&amp;from_uid=10410" ref="log$=recordlinks">Conserved Domains</a>
<div class="brieflinkpop offscreen_noflow">Related CDD</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/dbvar?LinkName=gene_dbvar&amp;from_uid=10410" ref="log$=recordlinks">dbVar</a>
<div class="brieflinkpop offscreen_noflow">Link from Gene to dbVar</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc&amp;from_uid=10410" ref="log$=recordlinks">Full text in PMC</a>
<div class="brieflinkpop offscreen_noflow">PMC links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc_nucleotide&amp;from_uid=10410" ref="log$=recordlinks">Full text in PMC_nucleotide</a>
<div class="brieflinkpop offscreen_noflow">Full text in PubMedCentral identified from shared sequence links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/sparcle?LinkName=gene_sparcle&amp;from_uid=10410" ref="log$=recordlinks">Functional Class</a>
<div class="brieflinkpop offscreen_noflow">Functional class of the sequence domain architecture</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gap?LinkName=gene_gap&amp;from_uid=10410" ref="log$=recordlinks">GAP</a>
<div class="brieflinkpop offscreen_noflow">GAP Links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gene?LinkName=gene_gene_neighbors&amp;from_uid=10410" ref="log$=recordlinks">Gene neighbors</a>
<div class="brieflinkpop offscreen_noflow">Overlapping genes and two nearest non-overlapping genes on either side</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/genome?LinkName=gene_genome&amp;from_uid=10410" ref="log$=recordlinks">Genome</a>
<div class="brieflinkpop offscreen_noflow">Related Genome</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/geoprofiles?LinkName=gene_geoprofiles&amp;from_uid=10410" ref="log$=recordlinks">GEO Profiles</a>
<div class="brieflinkpop offscreen_noflow">Related GEO</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gtr/tests/?term=10410[geneid]" ref="log$=recordlinks">GTR</a>
<div class="brieflinkpop offscreen_noflow">Tests for this gene in the NIH Genetic Testing Registry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/homologene?LinkName=gene_homologene&amp;from_uid=10410" ref="log$=recordlinks">HomoloGene</a>
<div class="brieflinkpop offscreen_noflow">Related HomoloGene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/medgen?LinkName=gene_medgen_diseases&amp;from_uid=10410" ref="log$=recordlinks">MedGen</a>
<div class="brieflinkpop offscreen_noflow">Related information in MedGen</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore&amp;from_uid=10410" ref="log$=recordlinks">Nucleotide</a>
<div class="brieflinkpop offscreen_noflow">Link to related Nucleotide entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/omim?LinkName=gene_omim&amp;from_uid=10410" ref="log$=recordlinks">OMIM</a>
<div class="brieflinkpop offscreen_noflow">Link to related OMIM entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/probe?LinkName=gene_probe&amp;from_uid=10410" ref="log$=recordlinks">Probe</a>
<div class="brieflinkpop offscreen_noflow">Related Probe entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein&amp;from_uid=10410" ref="log$=recordlinks">Protein</a>
<div class="brieflinkpop offscreen_noflow">Link to related protein entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pccompound?LinkName=gene_pccompound&amp;from_uid=10410" ref="log$=recordlinks">PubChem Compound</a>
<div class="brieflinkpop offscreen_noflow">PubChem Compounds</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcsubstance?LinkName=gene_pcsubstance&amp;from_uid=10410" ref="log$=recordlinks">PubChem Substance</a>
<div class="brieflinkpop offscreen_noflow">PubChem Substances</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed&amp;from_uid=10410" ref="log$=recordlinks">PubMed</a>
<div class="brieflinkpop offscreen_noflow">Link to related PubMed entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_rif&amp;from_uid=10410" ref="log$=recordlinks">PubMed (GeneRIF)</a>
<div class="brieflinkpop offscreen_noflow">Link to related PubMed article from GeneRIFs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_citedinomim&amp;from_uid=10410" ref="log$=recordlinks">PubMed (OMIM)</a>
<div class="brieflinkpop offscreen_noflow">Gene links to PubMed derived from omim_pubmed_cited links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_pmc_nucleotide&amp;from_uid=10410" ref="log$=recordlinks">PubMed(nucleotide/PMC)</a>
<div class="brieflinkpop offscreen_noflow">Citations in PubMed identified from shared sequence and PMC links.</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein_refseq&amp;from_uid=10410" ref="log$=recordlinks">RefSeq Proteins</a>
<div class="brieflinkpop offscreen_noflow">Link to Protein RefSeqs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore_refseqrna&amp;from_uid=10410" ref="log$=recordlinks">RefSeq RNAs</a>
<div class="brieflinkpop offscreen_noflow">Link to Nucleotide RefSeq RNAs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/nuccore/388490119?report=graph" ref="log$=recordlinks">RefSeqGene</a>
<div class="brieflinkpop offscreen_noflow">Link to Nucleotide RefSeqGenes</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/snp?LinkName=gene_snp&amp;from_uid=10410" ref="log$=recordlinks">SNP</a>
<div class="brieflinkpop offscreen_noflow">Related SNP records</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/taxonomy?LinkName=gene_taxonomy&amp;from_uid=10410" ref="log$=recordlinks">Taxonomy</a>
<div class="brieflinkpop offscreen_noflow">Link to related taxonomy entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/variation/view/?q=10410[geneid]" ref="log$=recordlinks">Variation Viewer</a>
<div class="brieflinkpop offscreen_noflow">Related Variants</div>
</li>
</ul>
</div>
</div>
<div class="portlet dis-links-to-other-res brieflink">
<div class="portlet_head">
<div class="portlet_title">
<h3>Links to other resources</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_LinksTwo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5414">HGNC</a>
</li>
<li>
<a href="http://www.ensembl.org/id/ENSG00000142089">Ensembl</a>
</li>
<li>
<a href="https://www.alliancegenome.org/gene/HGNC:5414">AllianceGenome</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=geneid&amp;org=9606&amp;l=10410">AceView</a>
</li>
<li>
<a href="http://www.pharmgkb.org/gene/PA29655">PharmGKB</a>
</li>
<li>
<a href="http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&amp;position=NM_021034">UCSC</a>
</li>
<li>
<a href="https://genecollections.nci.nih.gov/MGC/?ORG=Hs&amp;LIST=BC006794,BC008417,BC022439,BC070243">MGC</a>
</li>
<li>
<a href="https://phgkb.cdc.gov/PHGKB/huGEPedia.action?firstQuery=IFITM3&amp;geneID=10410&amp;typeOption=gene&amp;which=2&amp;pubOrderType=pubD&amp;typeSubmit=GO&amp;check=y">HuGE Navigator</a>
</li>
<li>
<a href="http://www.genome.jp/dbget-bin/www_bget?hsa:10410">KEGG</a>
</li>
<li>
<a href="https://reactome.org/content/query?q=UniProt:Q01628">Reactome</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-general-info">
<div class="portlet_head">
<div class="portlet_title">
<h3>General information</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GeneralInfo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="/pmc/?term=PMC4383897+OR+PMC3013746+OR+PMC1761442+OR+PMC539985">About Gene</a>
</li>
<li>
<a href="/books/NBK3840">FAQ</a>
</li>
<li>
<a href="https://ftp.ncbi.nlm.nih.gov/gene/">FTP site</a>
</li>
<li>
<a href="/books/NBK3841/">Help</a>
</li>
<li>
<a href="/books/NBK3842/">My NCBI help</a>
</li>
<li>
<a href="/books/NBK21085/">NCBI Handbook</a>
</li>
<li>
<a href="/gene/statistics/">Statistics</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-related-sites">
<div class="portlet_head">
<div class="portlet_title">
<h3>Related sites</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_RelatedSites" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://www.ncbi.nlm.nih.gov/BLAST">BLAST</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/genome">Genome</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/bioproject">BioProject</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/genome/gdv/">Genome Data Viewer</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/geo">GEO</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/omim">OMIM</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/probe">Probe</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/RefSeq">RefSeq</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-feedback">
<div class="portlet_head">
<div class="portlet_title">
<h3>Feedback</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_Feedback" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://support.ncbi.nlm.nih.gov/ics/support/ticketnewwizard.asp?style=classic&amp;deptID=28049">Contact Help Desk</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/RefSeq/update.cgi?geneid=10410&amp;symbol=IFITM3">Submit Correction</a>
</li>
<li>
<a href="/gene/submit-generif?geneId=10410&amp;sym=IFITM3&amp;name=interferon induced transmembrane protein 3&amp;org=Homo sapiens">Submit GeneRIF</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-subscription">
<div class="portlet_head">
<div class="portlet_title">
<h3>Subscription</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Subscription.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_Subscription" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Subscription.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://www.ncbi.nlm.nih.gov/mailman/listinfo/refseq-announce">RefSeq</a>
</li>
</ul>
</div>
</div>
</div>
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<h3>Recent activity</h3>
</div>
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Clear
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<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" sid="1" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOn" cmd="HTOff" href="?cmd=HTOff&amp;" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle">
Turn Off
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Turn On
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<ul id="activity">
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67c9df1084f3725e593201b4">IFITM3 interferon induced transmembrane protein 3 [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">IFITM3 interferon induced transmembrane protein 3 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:10410</div></div>
<div class="tertiary">Gene</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67c9df0fb15b832ebc056c4e">interferon-induced transmembrane protein 3 [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">interferon-induced transmembrane protein 3 [Homo sapiens]<div class="brieflinkpopdesc">gi|148612842|ref|NP_066362.2|</div></div>
<div class="tertiary">Protein</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67c9df0d84f3725e5931f24e">IFITM2 interferon induced transmembrane protein 2 [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">IFITM2 interferon induced transmembrane protein 2 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:10581</div></div>
<div class="tertiary">Gene</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67c9df0cf4a390645e329c6d">interferon-induced transmembrane protein 2 [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">interferon-induced transmembrane protein 2 [Homo sapiens]<div class="brieflinkpopdesc">gi|151101191|ref|NP_006426.2|</div></div>
<div class="tertiary">Protein</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67c9df0aa68b6b5afc6a3acd">IFITM1 interferon induced transmembrane protein 1 [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">IFITM1 interferon induced transmembrane protein 1 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:8519</div></div>
<div class="tertiary">Gene</div>
</li>
</ul>
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<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryOn" sid="1" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryOn" cmd="HTOn" href="?cmd=HTOn&amp;" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryOn">Turn recording back on</a>
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