899 lines
51 KiB
HTML
899 lines
51 KiB
HTML
<?xml version="1.0" encoding="utf-8"?>
|
||
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
|
||
<html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en" lang="en">
|
||
|
||
<head><meta http-equiv="Content-Type" content="text/html; charset=utf-8" />
|
||
<!-- AppResources meta begin -->
|
||
<meta name="paf-app-resources" content="" />
|
||
<!-- AppResources meta end -->
|
||
|
||
<!-- TemplateResources meta begin -->
|
||
<meta name="paf_template" content="StdNCol" />
|
||
|
||
<!-- TemplateResources meta end -->
|
||
|
||
<!-- Page meta begin -->
|
||
|
||
<!-- Page meta end -->
|
||
|
||
<!-- Logger begin -->
|
||
<meta xmlns:ncbi-portal="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" name="ncbi_app" content="genbank" /><meta xmlns:ncbi-portal="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" name="ncbi_pdid" content="custom-page" />
|
||
<!-- Logger end -->
|
||
|
||
<title>Submission of annotation using a 5-column tab-delimited feature table</title>
|
||
|
||
<!-- PageFixtures headcontent begin -->
|
||
|
||
<meta name="cms-local-nav-url" content="https://cms.ncbi.nlm.nih.gov//genbank/_nav" />
|
||
|
||
<!-- PageFixtures headcontent end -->
|
||
|
||
<!-- AppResources external_resources begin -->
|
||
<script type="text/javascript" src="/core/jig/1.15.6/js/jig.min.js"></script>
|
||
|
||
<!-- AppResources external_resources end -->
|
||
|
||
<!-- Page headcontent begin -->
|
||
<meta name="subsite" content="genbank" />
|
||
<meta name="path" content="genbank/feature_table" />
|
||
<meta name="modified" content="2024-07-17T20:12:42Z" />
|
||
<!-- Page headcontent end -->
|
||
<!-- PageFixtures resources begin -->
|
||
<link xmlns="http://www.w3.org/1999/xhtml" type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4218191/css/4207974/4206132.css" xml:base="http://127.0.0.1/sites/static/header_footer" />
|
||
|
||
<!-- PageFixtures resources end -->
|
||
<link rel="shortcut icon" href="//www.ncbi.nlm.nih.gov/favicon.ico" /><meta name="ncbi_phid" content="CE8B1C5A7D9FE9410000000000BB009C.m_5" />
|
||
<meta name='referrer' content='origin-when-cross-origin'/><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4218137/css/4121862/3974050/3917732/251717/4108189/14534/45193/3534283/4128070/3407145/4005757/4062871.css" /><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4218137/css/3529741/3529739.css" media="print" /></head>
|
||
<body class=" custom-page">
|
||
<div class="grid">
|
||
<div class="col twelve_col nomargin shadow">
|
||
<!-- System messages like service outage or JS required; this is handled by the TemplateResources portlet -->
|
||
<div class="sysmessages">
|
||
<noscript>
|
||
<p class="nojs">
|
||
<strong>Warning:</strong>
|
||
The NCBI web site requires JavaScript to function.
|
||
<a href="/guide/browsers/#enablejs" title="Learn how to enable JavaScript" target="_blank">more...</a>
|
||
</p>
|
||
</noscript>
|
||
</div>
|
||
<!--/.sysmessage-->
|
||
<div class="wrap">
|
||
<div class="page">
|
||
<div xmlns:xi="http://www.w3.org/2001/XInclude">
|
||
<div xmlns="http://www.w3.org/1999/xhtml" id="universal_header" xml:base="http://127.0.0.1/sites/static/header_footer">
|
||
<section class="usa-banner">
|
||
<div class="usa-accordion">
|
||
<header class="usa-banner-header">
|
||
<div class="usa-grid usa-banner-inner">
|
||
<img src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png" alt="U.S. flag" />
|
||
<p>An official website of the United States government</p>
|
||
<button class="non-usa-accordion-button usa-banner-button" aria-expanded="false" aria-controls="gov-banner-top" type="button">
|
||
<span class="usa-banner-button-text">Here's how you know</span>
|
||
</button>
|
||
</div>
|
||
</header>
|
||
<div class="usa-banner-content usa-grid usa-accordion-content" id="gov-banner-top" aria-hidden="true">
|
||
<div class="usa-banner-guidance-gov usa-width-one-half">
|
||
<img class="usa-banner-icon usa-media_block-img" src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg" alt="Dot gov" />
|
||
<div class="usa-media_block-body">
|
||
<p>
|
||
<strong>The .gov means it's official.</strong>
|
||
<br />
|
||
Federal government websites often end in .gov or .mil. Before
|
||
sharing sensitive information, make sure you're on a federal
|
||
government site.
|
||
</p>
|
||
</div>
|
||
</div>
|
||
<div class="usa-banner-guidance-ssl usa-width-one-half">
|
||
<img class="usa-banner-icon usa-media_block-img" src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg" alt="Https" />
|
||
<div class="usa-media_block-body">
|
||
<p>
|
||
<strong>The site is secure.</strong>
|
||
<br />
|
||
The <strong>https://</strong> ensures that you are connecting to the
|
||
official website and that any information you provide is encrypted
|
||
and transmitted securely.
|
||
</p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
<div class="usa-overlay"></div>
|
||
<header class="ncbi-header" role="banner" data-section="Header">
|
||
|
||
<div class="usa-grid">
|
||
<div class="usa-width-one-whole">
|
||
|
||
<div class="ncbi-header__logo">
|
||
<a href="/" class="logo" aria-label="NCBI Logo" data-ga-action="click_image" data-ga-label="NIH NLM Logo">
|
||
<img src="https://www.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg" alt="NIH NLM Logo" />
|
||
</a>
|
||
</div>
|
||
|
||
<div class="ncbi-header__account">
|
||
<a id="account_login" href="https://account.ncbi.nlm.nih.gov" class="usa-button header-button" style="display:none" data-ga-action="open_menu" data-ga-label="account_menu">Log in</a>
|
||
<button id="account_info" class="header-button" style="display:none" aria-controls="account_popup" type="button">
|
||
<span class="fa fa-user" aria-hidden="true">
|
||
<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" width="20px" height="20px">
|
||
<g style="fill: #fff">
|
||
<ellipse cx="12" cy="8" rx="5" ry="6"></ellipse>
|
||
<path d="M21.8,19.1c-0.9-1.8-2.6-3.3-4.8-4.2c-0.6-0.2-1.3-0.2-1.8,0.1c-1,0.6-2,0.9-3.2,0.9s-2.2-0.3-3.2-0.9 C8.3,14.8,7.6,14.7,7,15c-2.2,0.9-3.9,2.4-4.8,4.2C1.5,20.5,2.6,22,4.1,22h15.8C21.4,22,22.5,20.5,21.8,19.1z"></path>
|
||
</g>
|
||
</svg>
|
||
</span>
|
||
<span class="username desktop-only" aria-hidden="true" id="uname_short"></span>
|
||
<span class="sr-only">Show account info</span>
|
||
</button>
|
||
</div>
|
||
|
||
<div class="ncbi-popup-anchor">
|
||
<div class="ncbi-popup account-popup" id="account_popup" aria-hidden="true">
|
||
<div class="ncbi-popup-head">
|
||
<button class="ncbi-close-button" data-ga-action="close_menu" data-ga-label="account_menu" type="button">
|
||
<span class="fa fa-times">
|
||
<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 48 48" width="24px" height="24px">
|
||
<path d="M38 12.83l-2.83-2.83-11.17 11.17-11.17-11.17-2.83 2.83 11.17 11.17-11.17 11.17 2.83 2.83 11.17-11.17 11.17 11.17 2.83-2.83-11.17-11.17z"></path>
|
||
</svg>
|
||
</span>
|
||
<span class="usa-sr-only">Close</span></button>
|
||
<h4>Account</h4>
|
||
</div>
|
||
<div class="account-user-info">
|
||
Logged in as:<br />
|
||
<b><span class="username" id="uname_long">username</span></b>
|
||
</div>
|
||
<div class="account-links">
|
||
<ul class="usa-unstyled-list">
|
||
<li><a id="account_myncbi" href="/myncbi/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_myncbi">Dashboard</a></li>
|
||
<li><a id="account_pubs" href="/myncbi/collections/bibliography/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_pubs">Publications</a></li>
|
||
<li><a id="account_settings" href="/account/settings/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_settings">Account settings</a></li>
|
||
<li><a id="account_logout" href="/account/signout/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_logout">Log out</a></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
</header>
|
||
<div role="navigation" aria-label="access keys">
|
||
<a id="nws_header_accesskey_0" href="https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys" class="usa-sr-only" accesskey="0" tabindex="-1">Access keys</a>
|
||
<a id="nws_header_accesskey_1" href="https://www.ncbi.nlm.nih.gov" class="usa-sr-only" accesskey="1" tabindex="-1">NCBI Homepage</a>
|
||
<a id="nws_header_accesskey_2" href="/myncbi/" class="set-base-url usa-sr-only" accesskey="2" tabindex="-1">MyNCBI Homepage</a>
|
||
<a id="nws_header_accesskey_3" href="#maincontent" class="usa-sr-only" accesskey="3" tabindex="-1">Main Content</a>
|
||
<a id="nws_header_accesskey_4" href="#" class="usa-sr-only" accesskey="4" tabindex="-1">Main Navigation</a>
|
||
</div>
|
||
<section data-section="Alerts">
|
||
<div class="ncbi-alerts-placeholder"></div>
|
||
</section>
|
||
</div>
|
||
</div>
|
||
<!--/.header-->
|
||
<div class="header">
|
||
<div class="res_logo"><h1 class="res_name"><a href="/genbank/" title="GenBank home">GenBank</a></h1><h2 class="res_tagline">Public nucleic acid sequence repository</h2></div>
|
||
<div class="search"><form method="get" action="/nuccore/"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="nuccore" selected="selected">Nucleotide</option><option value="books">Books</option><option value="pmc">PMC</option><option value="gquery" class="last">All Databases</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene">Gene</option><option value="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen">MedGen</option><option value="mesh">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search Nucleotide" value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="isEnabled:false,disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'no',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div></form></div>
|
||
|
||
</div>
|
||
<div class="nav_and_browser">
|
||
<div class="localnav"><ul class="jig-ncbilocalnav">
|
||
<li><a href="#">GenBank</a><ul>
|
||
<li><a href="/genbank/">About GenBank</a></li>
|
||
<li><a href="/genbank/submit_types">Submission Types</a></li>
|
||
<li><a href="/genbank/submit">Submission Tools</a></li>
|
||
<li><a href="/genbank/update">Update GenBank Records</a></li>
|
||
<li><a href="/nuccore/">Search</a></li>
|
||
<li><a href="/BLAST/Blast.cgi?CMD=Web&PAGETYPE=BLASTHome">BLAST</a></li>
|
||
<li><a href="/genbank/statistics">Statistics</a></li>
|
||
<li><a href="/genbank/samplerecord/">Sample Record</a></li>
|
||
<li><a href="/genbank/sequencerevisionhistory/">Revision History</a></li>
|
||
<li><a href="/genbank/sequenceids/">Sequence IDs</a></li>
|
||
</ul>
|
||
</li>
|
||
<li><a href="#">Submit</a><ul>
|
||
<li><a href="/genbank/submit">Submission Tools</a></li>
|
||
<li><a href="/genbank/submit_types">Submission Types</a></li>
|
||
<li><a href="/WebSub/?tool=genbank">BankIt</a></li>
|
||
<li><a href="/genbank/table2asn">table2asn</a></li>
|
||
<li><a href="https://www.ncbi.nlm.nih.gov/sra/docs/sequence-data-processing">Sequence Data Processing</a></li>
|
||
</ul>
|
||
</li>
|
||
<li><a href="#">Genomes</a><ul>
|
||
<li><a href="/genbank/genomesubmit">Complete Genome Submission Guide</a></li>
|
||
<li><a href="/genbank/genomesubmit_annotation">Prokaryotic Genome Annotation Guide</a></li>
|
||
<li><a href="/genbank/eukaryotic_genome_submission_annotation">Eukaryotic Genome Annotation Guide</a></li>
|
||
<li><a href="/genbank/examples.wgs">Annotation Examples</a></li>
|
||
<li><a href="https://submit.ncbi.nlm.nih.gov/subs/wgs/">Genome Submission Portal</a></li>
|
||
</ul>
|
||
</li>
|
||
<li><a title="Whole Genome Shotgun sequences and submissions" href="#">WGS</a><ul>
|
||
<li><a href="/genbank/wgs">About WGS</a></li>
|
||
<li><a href="/Traces/wgs">WGS Project List</a></li>
|
||
<li><a href="/genbank/wgs.submit">WGS Submission Guide</a></li>
|
||
<li><a href="/genbank/wgsfaq/">FAQ</a></li>
|
||
<li><a href="https://submit.ncbi.nlm.nih.gov/subs/wgs/">Genome Submission Portal</a></li>
|
||
<li><a href="/genbank/eukaryotic_genome_submission_annotation">Eukaryotic Annotation Guide</a></li>
|
||
<li><a href="/genbank/genomesubmit_annotation">Prokaryotic Annotation Guide</a></li>
|
||
<li><a href="/genbank/asndisc">Discrepancy Report</a></li>
|
||
<li><a href="/assembly/agp/AGP_Specification/">AGP format</a></li>
|
||
</ul>
|
||
</li>
|
||
<li><a href="#">Metagenomes</a><ul>
|
||
<li><a href="/genbank/metagenome">About Metagenomes</a></li>
|
||
<li><a href="/genbank/structuredcomment">Structured Comment</a></li>
|
||
</ul>
|
||
</li>
|
||
<li><a href="#">TPA</a><ul>
|
||
<li><a href="/genbank/TPA">About TPA</a></li>
|
||
<li><a href="/genbank/tpafaq">FAQ</a></li>
|
||
<li><a href="/genbank/TPA-Exp">TPA-Exp</a></li>
|
||
<li><a href="/genbank/TPA-Inf">TPA-Inf</a></li>
|
||
</ul>
|
||
</li>
|
||
<li><a href="#">TSA</a><ul>
|
||
<li><a href="/genbank/TSA">About TSA</a></li>
|
||
<li><a href="/genbank/TSAguide">TSA Submission Guide</a></li>
|
||
<li><a href="/genbank/TSAfaq">FAQ</a></li>
|
||
</ul>
|
||
</li>
|
||
<li><a href="#">INSDC</a><ul>
|
||
<li><a href="/genbank/collab">About INSDC</a></li>
|
||
<li><a href="/genbank/collab/country">Geographic Location Name List</a></li>
|
||
<li><a href="/genbank/collab/db_xref">db_xref List</a></li>
|
||
<li><a href="http://www.insdc.org/documents/feature_table.html">Feature Table</a></li>
|
||
</ul>
|
||
</li>
|
||
<li><a href="#">Documentation</a><ul>
|
||
<li><a href="https://www.ncbi.nlm.nih.gov/sra/docs/sequence-data-processing/">Sequence Data Processing</a></li>
|
||
<li><a href="/genbank/submission_brokers">Submission Brokers</a></li>
|
||
<li><a href="/genbank/acc_prefix">Accession Number Prefixes</a></li>
|
||
<li><a href="/genbank/organelle_submit/">Organelle Submission Guide</a></li>
|
||
<li><a href="/genbank/monkeypox_submission/">Monkeypox Submission Guide</a></li>
|
||
<li><a href="/genbank/validation/">Common Submission Errors</a> </li>
|
||
<li><a href="/genbank/sequencecheck/">Ribosomal Submission Errors</a></li>
|
||
<li><a href="/genbank/sequencecheck/virus">Common Sequence Errors</a></li>
|
||
<li><a href="https://support.nlm.nih.gov/knowledgebase/category/?id=CAT-01240">Submission FAQs</a></li>
|
||
</ul>
|
||
</li>
|
||
<li><a href="#">Other</a><ul>
|
||
<li><a href="/genbank/htgs">About HTGs</a></li>
|
||
<li><a href="/genbank/dbest">About EST</a></li>
|
||
<li><a href="/genbank/dbgss">About GSS</a></li>
|
||
<li><a href="/genbank/tls">About TLS</a></li>
|
||
<li><a href="/genbank/tlsguide">Submit TLS</a></li>
|
||
</ul>
|
||
</li>
|
||
</ul></div>
|
||
</div>
|
||
|
||
<!-- was itemctrl -->
|
||
<div class="container">
|
||
<div id="maincontent" class="content col twelve_col last">
|
||
<div class="col1">
|
||
<h1 id="submission-of-annotation-using-a">Submission of annotation using a 5-column tab-delimited feature table</h1>
|
||
|
||
|
||
<h2 id="introduction">Introduction</h2>
|
||
|
||
|
||
<p>The 5-column, tab-delimited feature table (referred to as a "feature table" in this document) format allows different kinds of features (e.g., gene, coding region) and qualifiers (e.g., /product, /note) to be included with sequence submissions. The valid features and qualifiers are restricted to <a href="http://www.insdc.org/documents/feature_table.html">those</a> approved by the International Nucleotide Sequence Database Collaboration. </p>
|
||
|
||
|
||
<p>Please refer to the section that applies to your use case for more information.</p>
|
||
|
||
|
||
<ul>
|
||
<li><a href="#ftbankit">Feature tables for use in BankIt, table2asn, and Accession update requests</a> </li>
|
||
<li>
|
||
<p><a href="#ftsp">Feature tables for use in the GenBank Submission Portal</a></p>
|
||
</li>
|
||
<li>
|
||
<p>When submitting an annotated prokaryotic or eukaryotic genome, please review the genome <a href="/genbank/genomesubmit">guidelines</a> and appropriate annotation details for <a href="/genbank/genomesubmit_annotation">prokaryotes</a> or <a href="/genbank/eukaryotic_genome_submission">eukaryotes</a>.</p>
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
<h2 id="ftbankit">Feature tables for use in BankIt, table2asn, and Accession update requests</h2>
|
||
|
||
|
||
<h3 id="table-layout">Table Layout</h3>
|
||
|
||
|
||
<p>The five-column, tab-delimited feature table specifies the location and type of each feature. The first line of the table contains the following basic information:</p>
|
||
|
||
|
||
<p>›Feature SeqId table_name</p>
|
||
|
||
|
||
<p>The sequence identifier (SeqId) must be the same as that used on the sequence. The table_name is optional. Subsequent lines of the table list the features. Each feature is on a separate line. Qualifiers describing that feature are on the line below. Columns are separated by tabs. </p>
|
||
|
||
|
||
<pre><code>Column 1: Start location of feature
|
||
Column 2: Stop location of feature
|
||
Column 3: Feature key
|
||
Line2:
|
||
Column 4: Qualifier key
|
||
Column 5: Qualifier value
|
||
</code></pre>
|
||
|
||
|
||
<p>Figure 1 shows a sample table and illustrates several points about the table format. The GenBank flatfile corresponding to this table is shown in Figure 2. </p>
|
||
|
||
|
||
<ul>
|
||
<li>Features that are on the complementary strand, such as the gene YPR027C and tRNA-Phe, are indicated by reversing the interval locations. </li>
|
||
<li>Locations of partial (incomplete) features are indicated with a ">" or "<" in front of the nucleotide location. The “<” symbol always appears in column 1 and “>” always appears in column 2, regardless of the strandedness of the feature. In this example, the first gene, CDS, and mRNA all begin upstream of the start of the nucleotide sequence. The "<" symbol indicates that they are 5' partial features. </li>
|
||
<li>For the protein of a CDS that is partial at its 5’ end to translate correctly, the first nucleotide of the CDS that is the first base of the first complete codon must be indicated with the qualifier "codon_start". This is not the reading frame of the entire sequence; it is just the nucleotide position within the CDS. In the example, nucleotide 2 begins the first complete codon of the acid trehalase CDS. The default situation is that the codon_start is 1. There is no need to indicate the codon_start on complete CDSs, as the translation always begins at the first nucleotide of the interval.</li>
|
||
<li>If a feature contains multiple intervals, like the spliced tRNA-Phe or the Yip2p CDS, each interval is listed on a separate line by its start and stop position before subsequent qualifier lines. </li>
|
||
<li>Gene features are always a single interval, and their location should cover the intervals of all the relevant features. For example, the gene YIP2 is as long as its mRNA, and is thus longer than its CDS. </li>
|
||
<li>If the gene feature spans the intervals of the CDS or mRNA features for that gene, there is no need to include gene qualifiers on those features in the table, because they will be picked up by overlap. For example, in the flatfile, the gene names ATH1 and YPR027C are present as /gene on the overlapping CDS, even though they are not explicitly listed as gene qualifiers on those CDSs in the table. This option can be suppressed by adding a gene qualifier with the value '-' to the feature. Suppressing the overlapping /gene is important when, for example, a tRNA is encoded within an intron of a housekeeping gene. </li>
|
||
<li>If a protein has more than one name, each can be listed in the table as a separate product qualifier on the CDS in the table. The value of the first product qualifier will become the /product on the CDS in the flatfile, and any additional product qualifiers will be shown as a /note on the CDS in the flatfile. See the first CDS, which has two product qualifiers, acid trehalase and Ath1p. All CDS features must have at least one product. </li>
|
||
<li>A flatfile /note can be added to any feature using the qualifier note in the table. A note has been added to the second CDS. </li>
|
||
<li>Published citations are added using the REFERENCE feature. For most publications, the start and stop of the feature are the first and last nucleotides of the sequence. The qualifier key is PubMed, and the value is the PubMed Identifier (PMID), which can be found in <a href="//pubmed.ncbi.nlm.nih.gov">PubMed</a>. </li>
|
||
<li>The [offset] is used to add a specified number to all subsequent nucleotide intervals. In this example, the record was annotated in two pieces, each piece starting from residue number 1. The sequences themselves were joined together in the FASTA file. The [offset=2000] adds 2000 nt to the location of all features that follow it, sparing the submitter the need to recalculate the location of each feature. This option could be used if the feature intervals for two arms of a chromosome or adjacent contigs are stored separately, but need to be joined for the final submission. </li>
|
||
</ul>
|
||
|
||
|
||
<h3 id="figure-1-example-feature-table">Figure 1 : Example feature table</h3>
|
||
|
||
|
||
<pre><code>>Feature Sc_16
|
||
1 7000 REFERENCE
|
||
PubMed 8849441
|
||
<1 1050 gene
|
||
gene ATH1
|
||
<1 1009 CDS
|
||
product acid trehalase
|
||
product Ath1p
|
||
codon_start 2
|
||
<1 1050 mRNA
|
||
product acid trehalase
|
||
[offset=2000]
|
||
1253 420 gene
|
||
gene YPR027C
|
||
1253 420 CDS
|
||
product Ypr027cp
|
||
note hypothetical protein
|
||
1253 420 mRNA
|
||
product Ypr027cp
|
||
2626 2535 gene
|
||
gene trnF
|
||
2626 2590 tRNA
|
||
2570 2535
|
||
product tRNA-Phe
|
||
2626 2590 exon
|
||
number 1
|
||
2570 2535 exon
|
||
number 2
|
||
3450 4536 gene
|
||
gene YIP2
|
||
3522 3572 CDS
|
||
3706 4197
|
||
product Yip2p
|
||
prot_desc similar to human polyposis locus protein 1 (YPD)
|
||
3450 3572 mRNA
|
||
3706 4536
|
||
product Yip2p
|
||
</code></pre>
|
||
|
||
|
||
<h3 id="figure-2-genbank-flatfile">Figure 2 : GenBank flatfile</h3>
|
||
|
||
|
||
<pre><code>LOCUS Sc_16 7000 bp DNA PLN 08-MAY-2000
|
||
DEFINITION Saccharomyces cerevisiae strain S288C chromosome XVI, partial sequence.
|
||
ACCESSION Sc_16
|
||
VERSION
|
||
KEYWORDS .
|
||
SOURCE baker's yeast.
|
||
ORGANISM Saccharomyces cerevisiae
|
||
Eukaryota; Fungi; Ascomycota; Hemiascomycetes; Saccharomycetales;
|
||
Saccharomycetaceae; Saccharomyces.
|
||
REFERENCE 1 (bases 1 to 7000)
|
||
AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
|
||
Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
|
||
Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
|
||
Oliver,S.G.
|
||
TITLE Life with 6000 genes
|
||
JOURNAL Science 274 (5287), 546 (1996)
|
||
PUBMED 8849441
|
||
REFERENCE 2 (bases 1 to 7000)
|
||
AUTHORS Ouellette,B.F.F.
|
||
TITLE Direct Submission
|
||
JOURNAL Submitted (08-MAY-2000) NCBI/NLM, National Institutes of Health,
|
||
Building 38A, Room 8N805, Bethesda, MD 20894, USA
|
||
FEATURES Location/Qualifiers
|
||
source 1..7000
|
||
/organism="Saccharomyces cerevisiae"
|
||
/strain="S288C"
|
||
/chromosome="XVI"
|
||
mRNA <1..1050
|
||
/gene="ATH1"
|
||
/product="acid trehalase"
|
||
gene <1..1050
|
||
/gene="ATH1"
|
||
CDS <1..1009
|
||
/gene="ATH1"
|
||
/note="Ath1p"
|
||
/codon_start=2
|
||
/product="acid trehalase"
|
||
/translation="DHNGTIVHKSGDVPIHIKIPNRSLIHDQDINFYNGSENERKPNL
|
||
ERRDVDRVGDPMRMDRYGTYYLLKPKQELTVQLFKPGLNARNNIAENKQITNLTAGVP
|
||
GDVAFSALDGNNYTHWQPLDKIHRAKLLIDLGEYNEKEITKGMILWGQRPAKNISISI
|
||
LPHSEKVENLFANVTEIMQNSGNDQLLNETIGQLLDNAGIPVENVIDFDGIEQEDDES
|
||
LDDVQALLHWKKEDLAKLIEQIPRLNFLKRKFVKILDNVPVSPSEPYYEASRNQSLIE
|
||
ILPSNRTTFTIDYDKLQVGDKGNTDWRKTRYIVVAVQGVYDDYDDDNKGATIKEIVLN
|
||
D"
|
||
mRNA complement(2420..3253)
|
||
/gene="YPR027C"
|
||
/product="Ypr027cp"
|
||
gene complement(2420..3253)
|
||
/gene="YPR027C"
|
||
CDS complement(2420..3253)
|
||
/gene="YPR027C"
|
||
/note="hypothetical protein"
|
||
/codon_start=1
|
||
/product="Ypr027cp"
|
||
/translation="MVGIYRILASFVPLLGLLFAFHDDDMIDTVTIIKTVYETVTSTS
|
||
TAPAPAATKSVSEKKLDDTKLTLQVIQTMVSCFSVGENPANMISCGLGVVILMFSLII
|
||
ELINKLENDGINEPQRLYDLIKPKYVELPSNYVNEKIKTTFEPLDLYLGVNMNTSGSE
|
||
LNQNCLILKLGEKTALPFPGLAQQICYTKGASNEFTNYKLSDIQGNLNENSQGIANGV
|
||
FQKISNIRKISGNFKSQLYQISEKITDENWDGSAVGFTAHGREKGPNKSQISVSFYRD
|
||
N"
|
||
gene complement(4535..4626)
|
||
/gene="trnF"
|
||
tRNA complement(join(4535..4570,4590..4626))
|
||
/product="tRNA-Phe"
|
||
/gene="trnF"
|
||
exon complement(4535..4570)
|
||
/number=1
|
||
exon complement(4590..4626)
|
||
/number=2
|
||
mRNA join(5450..5572,5706..6536)
|
||
/gene="YIP2"
|
||
/product="Yip2p"
|
||
gene 5450..6536
|
||
/gene="YIP2"
|
||
CDS join(5522..5572,5706..6197)
|
||
/gene="YIP2"
|
||
/note="similar to human polyposis locus protein 1 (YPD)"
|
||
/codon_start=1
|
||
/product="Yip2p"
|
||
/translation="MSEYASSIHSQMKQFDTKYSGNRILQQLENKTNLPKSYLVAGLG
|
||
FAYLLLIFINVGGVGEILSNFAGFVLPAYLSLVALKTPTSTDDTQLLTYWIVFSFLSV
|
||
IEFWSKAILYLIPFYWFLKTVFLIYIALPQTGGARMIYQKIVAPLTDRYILRDVSKTE
|
||
KDEIRASVNEASKATGASVH"
|
||
BASE COUNT 2201 a 1276 c 1255 g 2268 t
|
||
ORIGIN
|
||
1 cgaccacaat ggtacgattg ttcataaatc aggagatgtt cctattcata taaagatacc
|
||
61 aaacagatct ctaatacatg accaggatat caacttctat aatggttccg aaaacgaaag
|
||
121 aaaaccaaat ctagagcgta gagacgtcga ccgtgttggt gatccaatga ggatggatag [etc.]
|
||
</code></pre>
|
||
|
||
|
||
<h3 id="applying-the-feature-table">Applying the feature table</h3>
|
||
|
||
|
||
<ul>
|
||
<li><a href="https://www.ncbi.nlm.nih.gov/WebSub/">Bankit</a> </li>
|
||
</ul>
|
||
|
||
|
||
<p>A feature table file may be imported on the Features page in a BankIt submission. On the Features step select “Add features by uploading five column feature table file”, then “Choose File”, select your file to upload, and then click the Upload file button. Your file will be validated. If there are no errors, the features will be imported where you can review the annotations and submit your data to GenBank. </p>
|
||
|
||
|
||
<ul>
|
||
<li><a href="https://www.ncbi.nlm.nih.gov/genbank/table2asn/">table2asn</a></li>
|
||
</ul>
|
||
|
||
|
||
<p>The command line program table2asn can be used to automate part of the submission process and is available via ftp. tbl2asn reads a template, along with the sequence and feature table files, and outputs ASN.1 for submission to GenBank. </p>
|
||
|
||
|
||
<ul>
|
||
<li><a href="/genbank/update">Updates</a></li>
|
||
</ul>
|
||
|
||
|
||
<p>Feature tables can be exported from existing public sequence records to help you prepare an update to your accessioned GenBank record. From the search result in Entrez, save the feature table using the Send to file option from the toolbar, specifying the format as feature table. Send your edited feature table to gb-admin@ncbi.nlm.nih.gov. </p>
|
||
|
||
|
||
<h2 id="ftsp">Feature tables for use in the GenBank Submission Portal</h2>
|
||
|
||
|
||
<p>Currently, the <a href="https://submit.ncbi.nlm.nih.gov/subs/genbank/">GenBank Submission Portal</a> accepts 5-column, tab-delimited feature tables for mRNA sequence submissions. Only gene, CDS, 5'UTR, and 3'UTR features are accepted. Other features are not yet supported but will be added in the future. If you include other feature types in your file, the annotation for those other features will not be applied to your submission. If you have questions about this, please reach out to: <a href="mailto:gb-admin@ncbi.nlm.nih.gov">gb-admin@ncbi.nlm.nih.gov</a>.</p>
|
||
|
||
|
||
<h3 id="preparing-the-feature-table-file">Preparing the feature table file for a GenBank Submission Portal Submission</h3>
|
||
|
||
|
||
<p><strong>File type</strong></p>
|
||
|
||
|
||
<p>The file must be a plain ascii text file. Do not save your file as .rtf., .xls, .docx, or any binary file types, as our software cannot read these. If you use a spreadsheet program to prepare your feature table, save it as tab-delimited text. </p>
|
||
|
||
|
||
<p><strong>General format for a feature table</strong></p>
|
||
|
||
|
||
<p>Review the example tables in <a href="#ftfig3">Figure 3</a> while you read this section to help you understand the feature table format. </p>
|
||
|
||
|
||
<p>The first line of the feature table contains the following basic information, like this example:</p>
|
||
|
||
|
||
<pre><code>>Feature sequence_ID
|
||
</code></pre>
|
||
|
||
|
||
<p>The sequence identifiers (sequence_ID) must match exactly the sequence_IDs in your nucleotide FASTA file.
|
||
The next lines contain information about the features and qualifiers:</p>
|
||
|
||
|
||
<ul>
|
||
<li>Each feature is on a separate line.</li>
|
||
<li>Qualifiers describing a feature are on the lines below that feature and its intervals.</li>
|
||
<li>Each column is separated by a tab.</li>
|
||
</ul>
|
||
|
||
|
||
<h1 id="_1"></h1>
|
||
|
||
|
||
<pre><code>Column 1: Start location (first nucleotide) of a feature
|
||
Column 2: Stop location (last nucleotide) of a feature
|
||
Column 3: Feature key (for example, 'CDS' or 'gene')
|
||
Column 4: Qualifier key (for example, 'product' or 'gene' or 'note')
|
||
Column 5: Qualifier value
|
||
</code></pre>
|
||
|
||
|
||
<h3 id="ftfig3">Figure 3 : Example table</h3>
|
||
|
||
|
||
<pre><code>>Feature Seq1
|
||
1 1210 CDS
|
||
product acid trehalase 1
|
||
>Feature Seq2
|
||
<1 >1050 gene
|
||
gene ATH2
|
||
<1 >1050 CDS
|
||
product acid trehalase 2
|
||
codon_start 3
|
||
>Feature Seq3
|
||
<1 1600 gene
|
||
gene ATH4
|
||
<1 9 5'UTR
|
||
10 1550 CDS
|
||
product acid trehalase 4
|
||
1551 1600 3'UTR
|
||
>Feature Seq4
|
||
1150 1 gene
|
||
gene ATH3
|
||
1150 1 CDS
|
||
product acid trehalase 3
|
||
note alternatively spliced
|
||
</code></pre>
|
||
|
||
|
||
<h3 id="example-feature-table-explained">Example feature table explained</h3>
|
||
|
||
|
||
<p>The examples in <a href="#ftfig3">Figure 3</a> illustrate several points about the table format:</p>
|
||
|
||
|
||
<p><strong>Complete and partial features</strong></p>
|
||
|
||
|
||
<p><em>Complete features - the sequence contains the complete feature.</em> </p>
|
||
|
||
|
||
<ul>
|
||
<li>
|
||
<p>The features are complete in the Seq1 and Seq4 examples.</p>
|
||
</li>
|
||
<li>
|
||
<p>A complete CDS begins with the first codon that is translated and ends with the terminal stop codon. </p>
|
||
</li>
|
||
<li>
|
||
<p>For a complete CDS, there should be no use of ">" or "<" next to the nucleotide start and stop position numbers. You do not need to indicate codon_start for a complete CDS, as it is assumed that the translation starts at the first nucleotide of the interval.</p>
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
<p><em>Partial features - the sequence does not contain the full feature at either (or both) ends.</em> </p>
|
||
|
||
|
||
<ul>
|
||
<li>
|
||
<p>Locations of partial (incomplete) features are indicated with a ">" or "<" next to the first and last nucleotide position numbers. </p>
|
||
</li>
|
||
<li>
|
||
<p>In the Seq2 example, both the gene and CDS features are partial at the 5' and 3' ends of the sequence. In other words, the CDS begins upstream of the start of the nucleotide sequence and ends downstream of the nucleotide sequence (the sequence does not contain the start codon or stop codon). The "<" symbol next to the first nucleotide location indicates a 5' partial feature and the ">" symbol next to the last nucleotide location indicates the CDS feature is 3' partial. Furthermore, for the protein to translate correctly, the correct reading frame must be indicated with the qualifier "codon_start" on the CDS if the sequence is 5' partial. The valid qualifier value for codon_start is 1, 2, or 3. The codon_start qualifier is only valid for a CDS feature. </p>
|
||
</li>
|
||
<li>
|
||
<p>In the Seq3 example, the sequence contains part of the 5'UTR. The 5'UTR is 5' partial as indicated by the < next to the nucleotide position 1. Since the 5'UTR for this gene is 5' partial, the gene is also 5' partial. The CDS and 3'UTR are complete in this example and do not have the < or > symbols.</p>
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
<p><strong>Gene features</strong> </p>
|
||
|
||
|
||
<ul>
|
||
<li>
|
||
<p>The Seq2, Seq3, and Seq4 examples have gene features. </p>
|
||
</li>
|
||
<li>
|
||
<p>In the examples, 'gene' is both a feature and a qualifier and must be entered in two separate lines and columns.</p>
|
||
</li>
|
||
<li>
|
||
<p>Gene features are always a single interval.</p>
|
||
</li>
|
||
<li>
|
||
<p>The gene intervals should cover the intervals of all the features associated with that gene. For example, Seq3 has gene intervals which include the 5'UTR, CDS, and 3'UTR. </p>
|
||
</li>
|
||
<li>
|
||
<p>The gene partialness follows the partialness of the features within the gene. See the section "Complete and partial features" for information on annotating partial features. </p>
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
<p><strong>CDS features</strong> </p>
|
||
|
||
|
||
<ul>
|
||
<li>
|
||
<p>Protein-coding sequences should have a CDS feature. </p>
|
||
</li>
|
||
<li>
|
||
<p>CDS features must have a product qualifier and qualifier value. The CDS product is the name of the protein encoded by the sequence. For example, see Seq1 which has the value 'acid trehalase 1' for the CDS product qualifier. </p>
|
||
</li>
|
||
<li>
|
||
<p>If a sequence does not contain the translation start codon and/or a stop codon, the CDS is partial. See the section "Complete and partial features" for information on annotating partial features. </p>
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
<p><strong>Note qualifier</strong></p>
|
||
|
||
|
||
<ul>
|
||
<li>A note can be added to any feature using the 'note' qualifier. See Seq4 for an example of a CDS feature with a note qualifier.</li>
|
||
</ul>
|
||
|
||
|
||
<p><strong>Features on the complementary strand</strong></p>
|
||
|
||
|
||
<ul>
|
||
<li>Features on the complementary strand are indicated by reversing the interval locations. An example of this is shown in Seq4.</li>
|
||
</ul>
|
||
|
||
|
||
<h3 id="applying-a-feature-table-in-subm">Applying a feature table in submission portal</h3>
|
||
|
||
|
||
<p>A feature table file may be imported in the GenBank Submission Portal for submission workflows that do not have an automated feature annotation component. Submission workflows that do not have automated feature annotation will request this information from you on the Features page. Upload a feature table on the Features step by selecting “Add features by file upload”, then “5-column tab-delimited feature table”, and then "Upload file”. Your file will be validated. If there are no errors, the features will be imported where you can then review the annotations and submit your data to GenBank. </p>
|
||
</div>
|
||
<!--/.col1-->
|
||
<div class="col2">
|
||
|
||
</div>
|
||
<!--/.col2-->
|
||
<div class="col3">
|
||
|
||
</div>
|
||
<!--/.col3-->
|
||
<div class="col4">
|
||
|
||
</div>
|
||
<!--/.col4-->
|
||
<div class="col5">
|
||
|
||
</div>
|
||
<div class="col6">
|
||
|
||
</div>
|
||
<div class="col7">
|
||
|
||
</div>
|
||
<div class="col8">
|
||
|
||
</div>
|
||
<div class="col9">
|
||
|
||
</div>
|
||
</div><!--/.content-->
|
||
</div><!--/.container-->
|
||
<div id="NCBIFooter_dynamic">
|
||
<div class="breadcrumbs">You are here:
|
||
<span id="breadcrumb_text"><a href="/guide/">NCBI</a></span></div>
|
||
<a id="help-desk-link" class="help_desk" href="https://support.ncbi.nlm.nih.gov/ics/support/default.asp?Time=2025-03-18T20:05:07-04:00&Snapshot=%2Fprojects%2Fstaticsites%2Fgenbank%2Fgenbank@2.21&Host=portal104&ncbi_phid=CE8B1C5A7D9FE9410000000000BB009C&ncbi_session=CE8BC1E97D9F05E1_0182SID&from=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fgenbank%2Ffeature_table%2F&Ncbi_App=genbank&Page=custom-page&style=classic&deptID=28049" target="_blank">Support Center</a>
|
||
<noscript><img alt="" src="/stat?jsdisabled=true&ncbi_app=genbank&ncbi_db=&ncbi_pdid=custom-page&ncbi_phid=CE8B1C5A7D9FE9410000000000BB009C" /></noscript>
|
||
</div>
|
||
|
||
|
||
<div xmlns:xi="http://www.w3.org/2001/XInclude">
|
||
<div xmlns="http://www.w3.org/1999/xhtml" class="footer" id="footer" xml:base="http://127.0.0.1/sites/static/header_footer">
|
||
<section class="icon-section">
|
||
<div id="icon-section-header" class="icon-section_header">Follow NCBI</div>
|
||
<div class="grid-container container">
|
||
<div class="icon-section_container">
|
||
<a class="footer-icon" id="footer_twitter" href="https://twitter.com/ncbi" aria-label="Twitter">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="40" height="40" viewBox="0 0 40 40" fill="none">
|
||
<title>Twitter</title>
|
||
<g id="twitterx1008">
|
||
<path id="path1008" d="M6.06736 7L16.8778 20.8991L6.00001 32.2H10.2L18.6 23.1L25.668 32.2H34L22.8 17.5L31.9 7H28.4L20.7 15.4L14.401 7H6.06898H6.06736ZM9.66753 8.73423H12.9327L29.7327 30.4658H26.5697L9.66753 8.73423Z" fill="#5B616B"></path>
|
||
</g>
|
||
</svg>
|
||
</a>
|
||
<a class="footer-icon" id="footer_facebook" href="https://www.facebook.com/ncbi.nlm" aria-label="Facebook"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
|
||
<title>Facebook</title>
|
||
<path class="cls-11" d="M210.5,115.12H171.74V97.82c0-8.14,5.39-10,9.19-10h27.14V52l-39.32-.12c-35.66,0-42.42,26.68-42.42,43.77v19.48H99.09v36.32h27.24v109h45.41v-109h35Z">
|
||
</path>
|
||
</svg></a>
|
||
<a class="footer-icon" id="footer_linkedin" href="https://www.linkedin.com/company/ncbinlm" aria-label="LinkedIn"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
|
||
<title>LinkedIn</title>
|
||
<path class="cls-11" d="M101.64,243.37H57.79v-114h43.85Zm-22-131.54h-.26c-13.25,0-21.82-10.36-21.82-21.76,0-11.65,8.84-21.15,22.33-21.15S101.7,78.72,102,90.38C102,101.77,93.4,111.83,79.63,111.83Zm100.93,52.61A17.54,17.54,0,0,0,163,182v61.39H119.18s.51-105.23,0-114H163v13a54.33,54.33,0,0,1,34.54-12.66c26,0,44.39,18.8,44.39,55.29v58.35H198.1V182A17.54,17.54,0,0,0,180.56,164.44Z">
|
||
</path>
|
||
</svg></a>
|
||
<a class="footer-icon" id="footer_github" href="https://github.com/ncbi" aria-label="GitHub"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
|
||
<defs>
|
||
<style>
|
||
.cls-11,
|
||
.cls-12 {
|
||
fill: #737373;
|
||
}
|
||
|
||
.cls-11 {
|
||
fill-rule: evenodd;
|
||
}
|
||
</style>
|
||
</defs>
|
||
<title>GitHub</title>
|
||
<path class="cls-11" d="M151.36,47.28a105.76,105.76,0,0,0-33.43,206.1c5.28,1,7.22-2.3,7.22-5.09,0-2.52-.09-10.85-.14-19.69-29.42,6.4-35.63-12.48-35.63-12.48-4.81-12.22-11.74-15.47-11.74-15.47-9.59-6.56.73-6.43.73-6.43,10.61.75,16.21,10.9,16.21,10.9,9.43,16.17,24.73,11.49,30.77,8.79,1-6.83,3.69-11.5,6.71-14.14C108.57,197.1,83.88,188,83.88,147.51a40.92,40.92,0,0,1,10.9-28.39c-1.1-2.66-4.72-13.42,1-28,0,0,8.88-2.84,29.09,10.84a100.26,100.26,0,0,1,53,0C198,88.3,206.9,91.14,206.9,91.14c5.76,14.56,2.14,25.32,1,28a40.87,40.87,0,0,1,10.89,28.39c0,40.62-24.74,49.56-48.29,52.18,3.79,3.28,7.17,9.71,7.17,19.58,0,14.15-.12,25.54-.12,29,0,2.82,1.9,6.11,7.26,5.07A105.76,105.76,0,0,0,151.36,47.28Z">
|
||
</path>
|
||
<path class="cls-12" d="M85.66,199.12c-.23.52-1.06.68-1.81.32s-1.2-1.06-.95-1.59,1.06-.69,1.82-.33,1.21,1.07.94,1.6Zm-1.3-1">
|
||
</path>
|
||
<path class="cls-12" d="M90,203.89c-.51.47-1.49.25-2.16-.49a1.61,1.61,0,0,1-.31-2.19c.52-.47,1.47-.25,2.17.49s.82,1.72.3,2.19Zm-1-1.08">
|
||
</path>
|
||
<path class="cls-12" d="M94.12,210c-.65.46-1.71,0-2.37-.91s-.64-2.07,0-2.52,1.7,0,2.36.89.65,2.08,0,2.54Zm0,0"></path>
|
||
<path class="cls-12" d="M99.83,215.87c-.58.64-1.82.47-2.72-.41s-1.18-2.06-.6-2.7,1.83-.46,2.74.41,1.2,2.07.58,2.7Zm0,0">
|
||
</path>
|
||
<path class="cls-12" d="M107.71,219.29c-.26.82-1.45,1.2-2.64.85s-2-1.34-1.74-2.17,1.44-1.23,2.65-.85,2,1.32,1.73,2.17Zm0,0">
|
||
</path>
|
||
<path class="cls-12" d="M116.36,219.92c0,.87-1,1.59-2.24,1.61s-2.29-.68-2.3-1.54,1-1.59,2.26-1.61,2.28.67,2.28,1.54Zm0,0">
|
||
</path>
|
||
<path class="cls-12" d="M124.42,218.55c.15.85-.73,1.72-2,1.95s-2.37-.3-2.52-1.14.73-1.75,2-2,2.37.29,2.53,1.16Zm0,0"></path>
|
||
</svg></a>
|
||
<a class="footer-icon" id="footer_blog" href="https://ncbiinsights.ncbi.nlm.nih.gov/" aria-label="Blog">
|
||
<svg xmlns="http://www.w3.org/2000/svg" id="Layer_1" data-name="Layer 1" viewBox="0 0 40 40">
|
||
<defs><style>.cls-1{fill:#737373;}</style></defs>
|
||
<title>NCBI Insights Blog</title>
|
||
<path class="cls-1" d="M14,30a4,4,0,1,1-4-4,4,4,0,0,1,4,4Zm11,3A19,19,0,0,0,7.05,15a1,1,0,0,0-1,1v3a1,1,0,0,0,.93,1A14,14,0,0,1,20,33.07,1,1,0,0,0,21,34h3a1,1,0,0,0,1-1Zm9,0A28,28,0,0,0,7,6,1,1,0,0,0,6,7v3a1,1,0,0,0,1,1A23,23,0,0,1,29,33a1,1,0,0,0,1,1h3A1,1,0,0,0,34,33Z"></path>
|
||
</svg>
|
||
</a>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
|
||
<section class="container-fluid bg-primary">
|
||
<div class="container pt-5">
|
||
<div class="row mt-3">
|
||
<div class="col-lg-3 col-12">
|
||
<p><a class="text-white" href="https://www.nlm.nih.gov/socialmedia/index.html">Connect with NLM</a></p>
|
||
<ul class="list-inline social_media">
|
||
<li class="list-inline-item"><a href="https://twitter.com/NLM_NIH" aria-label="Twitter" target="_blank" rel="noopener noreferrer">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="35" height="35" viewBox="0 0 36 35" fill="none">
|
||
<title>Twitter</title>
|
||
<g id="twitterx1009" clip-path="url(#clip0_65276_3946)">
|
||
<path id="Vector_Twitter" d="M17.5006 34.6565C26.9761 34.6565 34.6575 26.9751 34.6575 17.4996C34.6575 8.02416 26.9761 0.342773 17.5006 0.342773C8.02514 0.342773 0.34375 8.02416 0.34375 17.4996C0.34375 26.9751 8.02514 34.6565 17.5006 34.6565Z" fill="#205493" stroke="white" stroke-width="1.0" stroke-miterlimit="10"></path>
|
||
<path id="path1009" d="M8.54811 8.5L16.2698 18.4279L8.50001 26.5H11.5L17.5 20L22.5486 26.5H28.5L20.5 16L27 8.5H24.5L19 14.5L14.5007 8.5H8.54927H8.54811ZM11.1197 9.73873H13.4519L25.4519 25.2613H23.1926L11.1197 9.73873Z" fill="white"></path>
|
||
</g>
|
||
<defs>
|
||
<clipPath id="clip0_65276_3946">
|
||
<rect width="35" height="35" fill="white"></rect>
|
||
</clipPath>
|
||
</defs>
|
||
</svg>
|
||
</a></li>
|
||
<li class="list-inline-item"><a href="https://www.facebook.com/nationallibraryofmedicine" aria-label="Facebook" rel="noopener noreferrer" target="_blank">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="35" height="35" viewBox="0 0 36 35" fill="none">
|
||
<title>Facebook</title>
|
||
<g id="Facebook" clip-path="url(#clip0_1717_1086)">
|
||
<path id="Vector_Facebook" d="M15.1147 29.1371C15.1147 29.0822 15.1147 29.0296 15.1147 28.9747V18.9414H11.8183C11.6719 18.9414 11.6719 18.9414 11.6719 18.8018C11.6719 17.5642 11.6719 16.3289 11.6719 15.0937C11.6719 14.9793 11.7062 14.9518 11.816 14.9518C12.8683 14.9518 13.9206 14.9518 14.9751 14.9518H15.1215V14.8329C15.1215 13.8057 15.1215 12.774 15.1215 11.7492C15.1274 10.9262 15.3148 10.1146 15.6706 9.37241C16.1301 8.38271 16.9475 7.60378 17.9582 7.19235C18.6492 6.90525 19.3923 6.76428 20.1405 6.7783C21.0029 6.79202 21.8653 6.83091 22.7278 6.86065C22.8879 6.86065 23.048 6.89496 23.2082 6.90182C23.2974 6.90182 23.3271 6.94071 23.3271 7.02993C23.3271 7.54235 23.3271 8.05477 23.3271 8.5649C23.3271 9.16882 23.3271 9.77274 23.3271 10.3767C23.3271 10.4819 23.2974 10.5139 23.1921 10.5116C22.5379 10.5116 21.8814 10.5116 21.2271 10.5116C20.9287 10.5184 20.6316 10.5528 20.3395 10.6146C20.0822 10.6619 19.8463 10.7891 19.6653 10.9779C19.4842 11.1668 19.3672 11.4078 19.3307 11.6669C19.2857 11.893 19.2612 12.1226 19.2575 12.3531C19.2575 13.1904 19.2575 14.0299 19.2575 14.8695C19.2575 14.8946 19.2575 14.9198 19.2575 14.9564H23.0229C23.1807 14.9564 23.183 14.9564 23.1624 15.1074C23.0778 15.7662 22.9885 16.425 22.9039 17.0816C22.8322 17.6321 22.7636 18.1827 22.698 18.7332C22.6729 18.9437 22.6797 18.9437 22.4693 18.9437H19.2644V28.8992C19.2644 28.9793 19.2644 29.0593 19.2644 29.1394L15.1147 29.1371Z" fill="white"></path>
|
||
<path id="Vector_2_Facebook" d="M17.5006 34.657C26.9761 34.657 34.6575 26.9756 34.6575 17.5001C34.6575 8.02465 26.9761 0.343262 17.5006 0.343262C8.02514 0.343262 0.34375 8.02465 0.34375 17.5001C0.34375 26.9756 8.02514 34.657 17.5006 34.657Z" stroke="white" stroke-width="1.0" stroke-miterlimit="10"></path>
|
||
</g>
|
||
<defs>
|
||
<clipPath id="clip0_1717_1086">
|
||
<rect width="35" height="35" fill="white"></rect>
|
||
</clipPath>
|
||
</defs>
|
||
</svg>
|
||
</a></li>
|
||
<li class="list-inline-item"><a href="https://www.youtube.com/user/NLMNIH" aria-label="Youtube" target="_blank" rel="noopener noreferrer">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="35" height="35" viewBox="0 0 36 35" fill="none">
|
||
<title>Youtube</title>
|
||
<g id="YouTube" clip-path="url(#clip0_1717_1101)">
|
||
<path id="Vector_Youtube" d="M26.2571 11.4791C25.9025 11.1589 25.5709 10.9576 24.228 10.834C22.5512 10.6785 20.2797 10.6556 18.564 10.6533H16.4365C14.7208 10.6533 12.4493 10.6785 10.7725 10.834C9.43196 10.9576 9.09798 11.1589 8.7434 11.4791C7.81464 12.321 7.6202 14.6268 7.59961 16.8938C7.59961 17.3178 7.59961 17.741 7.59961 18.1635C7.62706 20.4121 7.82837 22.686 8.7434 23.521C9.09798 23.8412 9.42967 24.0425 10.7725 24.1661C12.4493 24.3216 14.7208 24.3445 16.4365 24.3468H18.564C20.2797 24.3468 22.5512 24.3216 24.228 24.1661C25.5686 24.0425 25.9025 23.8412 26.2571 23.521C27.1722 22.6929 27.3735 20.451 27.4009 18.2206C27.4009 17.7402 27.4009 17.2599 27.4009 16.7795C27.3735 14.5491 27.1699 12.3072 26.2571 11.4791ZM15.5604 20.5311V14.652L20.561 17.5001L15.5604 20.5311Z" fill="white"></path>
|
||
<path id="Vector_2_Youtube" d="M17.5006 34.657C26.9761 34.657 34.6575 26.9756 34.6575 17.5001C34.6575 8.02465 26.9761 0.343262 17.5006 0.343262C8.02514 0.343262 0.34375 8.02465 0.34375 17.5001C0.34375 26.9756 8.02514 34.657 17.5006 34.657Z" stroke="white" stroke-width="1.0" stroke-miterlimit="10"></path>
|
||
</g>
|
||
<defs>
|
||
<clipPath id="clip0_1717_1101">
|
||
<rect width="35" height="35" fill="white"></rect>
|
||
</clipPath>
|
||
</defs>
|
||
</svg>
|
||
</a></li>
|
||
</ul>
|
||
</div>
|
||
<div class="col-lg-3 col-12">
|
||
<p class="address_footer text-white">National Library of Medicine<br />
|
||
<a href="https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/@38.9959508,-77.101021,17z/data=!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb:0x19156f88b27635b8!8m2!3d38.9959508!4d-77.0988323" class="text-white" target="_blank" rel="noopener noreferrer">8600 Rockville Pike<br />
|
||
Bethesda, MD 20894</a></p>
|
||
</div>
|
||
<div class="col-lg-3 col-12 centered-lg">
|
||
<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
|
||
<a href="https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office" class="text-white">FOIA</a><br />
|
||
<a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" class="text-white" id="vdp">HHS Vulnerability Disclosure</a></p>
|
||
</div>
|
||
<div class="col-lg-3 col-12 centered-lg">
|
||
<p><a class="supportLink text-white" href="https://support.nlm.nih.gov/">Help</a><br />
|
||
<a href="https://www.nlm.nih.gov/accessibility.html" class="text-white">Accessibility</a><br />
|
||
<a href="https://www.nlm.nih.gov/careers/careers.html" class="text-white">Careers</a></p>
|
||
</div>
|
||
</div>
|
||
<div class="row">
|
||
<div class="col-lg-12 centered-lg">
|
||
<nav class="bottom-links">
|
||
<ul class="mt-3">
|
||
<li>
|
||
<a class="text-white" href="//www.nlm.nih.gov/">NLM</a>
|
||
</li>
|
||
<li>
|
||
<a class="text-white" href="https://www.nih.gov/">NIH</a>
|
||
</li>
|
||
<li>
|
||
<a class="text-white" href="https://www.hhs.gov/">HHS</a>
|
||
</li>
|
||
<li>
|
||
<a class="text-white" href="https://www.usa.gov/">USA.gov</a>
|
||
</li>
|
||
</ul>
|
||
</nav>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
<script type="text/javascript" src="/portal/portal3rc.fcgi/rlib/js/InstrumentOmnitureBaseJS/InstrumentNCBIConfigJS/InstrumentNCBIBaseJS/InstrumentPageStarterJS.js?v=1"> </script>
|
||
<script type="text/javascript" src="/portal/portal3rc.fcgi/static/js/hfjs2.js"> </script>
|
||
</div>
|
||
</div>
|
||
<!--/.footer-->
|
||
<p class="last-updated small">Last updated: 2024-07-17T20:12:42Z</p>
|
||
</div>
|
||
<!--/.page-->
|
||
</div>
|
||
<!--/.wrap-->
|
||
<span class="PAFAppResources"></span>
|
||
|
||
|
||
</div><!-- /.twelve_col -->
|
||
</div>
|
||
<!-- /.grid -->
|
||
|
||
|
||
|
||
<!-- usually for JS scripts at page bottom -->
|
||
<span class="pagefixtures"></span>
|
||
|
||
|
||
<!-- CE8BC1E97D9F05E1_0182SID /projects/staticsites/genbank/genbank@2.21 portal104 v4.1.r689238 Tue, Oct 22 2024 16:10:51 -->
|
||
<span id="portal-csrf-token" style="display:none" data-token="CE8BC1E97D9F05E1_0182SID"></span>
|
||
|
||
<script type="text/javascript" src="//static.pubmed.gov/portal/portal3rc.fcgi/4218137/js/3879255/4121861/1490097/4087685.js" snapshot="genbank"></script></body>
|
||
</html>
|
||
|