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117 KiB
XML
600 lines
No EOL
117 KiB
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<div class="header">
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<!-- logo -->
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<div class="res_logo"><h1 class="res_name"><a href="/gds">GEO DataSets</a></h1>
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<h2 class="res_tagline">Functional Genomics Studies</h2></div>
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<!-- SearchBar -->
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<div class="search"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="gds" selected="selected">GEO DataSets</option><option value="gene">Gene</option><option value="pmc">PMC</option><option value="nlmcatalog" class="last">NLM Catalog</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene">Gene</option><option value="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen" data-ac_dict="medgen_disease_name">MedGen</option><option value="mesh" data-ac_dict="mesh_suggestions">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed" data-ac_dict="pm_related_queries_2">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search GEO DataSets" value=""frameshift"[Function Class]" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="isEnabled:false,disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'yes',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div><ul class="searchlinks inline_list"><set></set><li><a name="SaveSearch" title="Click to create an email alert for this search" href="/sites/myncbi/searches/save?db=gds&qk=871" id="SaveSearch">Create alert</a></li><li><a href="/gds/advanced">Advanced</a></li><li class="help"><a id="help" class="jig-ncbihelpwindow" target="ncbihelp" name="help" href="/geo/info/datasets.html">Help</a></li></ul></div>
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</div>
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<input name="EntrezSystem2.PEntrez.Gds.Entrez_PageController.PreviousPageName" sid="1" type="hidden" value="results" />
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<div id="faceted_search" class="col two_col">
|
||
<h2 class="offscreen_noflow">Result Filters</h2>
|
||
<div class="facet_cont" data-db="gds" data-default_grps="fg_entryTypeGds,fg_organismGds,fg_studyTypeGds,fg_authorGds,fg_attNameGds,fg_pubDatesGds" data-sd="db:'gds',op:'search',term:'%22frameshift%22%5BFunction%20Class%5D',qk:'871',linkname:'',idsfromresult:'',extra:''"><ul class="facet" data-filter_id="entryTypeGds" id="_entryTypeGds"><li class="filter_grp "><div class="clearfix"><h3>Entry type</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="dataSetsGds">DataSets</a><span class="fcount">(0)</span></li><li class="fil_val"><a href="#" data-value_id="seriesGds">Series</a><span class="fcount">(184)</span></li><li class="fil_val"><a href="#" data-value_id="samplesGds">Samples</a><span class="fcount">(795)</span></li><li class="fil_val"><a href="#" data-value_id="platformsGds">Platforms</a><span class="fcount">(0)</span></li></ul></li></ul><ul class="facet" data-filter_id="organismGds" id="_organismGds" data-of="yes"><li class="filter_grp of_grp"><div class="clearfix"><h3>Organism</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="more"><a href="#organismGds_more" data-value_id="fetch_more" data-jigconfig=" hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '300px'">Customize ...</a><div style="display:none;" id="organismGds_more"></div></li></ul></li></ul><ul class="facet" data-filter_id="studyTypeGds" id="_studyTypeGds"><li class="filter_grp "><div class="clearfix"><h3>Study type</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="expProfByArrGds">Expression profiling by array</a></li><li class="fil_val"><a href="#" data-value_id="metProfByArrGds">Methylation profiling by array</a></li><li class="more"><a href="#studyTypeGds_more" data-value_id="fetch_more" data-jigconfig=" hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '300px'">Customize ...</a><div style="display:none;" id="studyTypeGds_more"></div></li></ul></li></ul><ul class="facet" data-filter_id="authorGds" id="_authorGds" data-of="yes"><li class="filter_grp of_grp"><div class="clearfix"><h3>Author</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="more"><a href="#authorGds_more" data-value_id="fetch_more" data-jigconfig=" hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '300px'">Customize ...</a><div style="display:none;" id="authorGds_more"></div></li></ul></li></ul><ul class="facet" data-filter_id="attNameGds" id="_attNameGds" data-of="yes"><li class="filter_grp of_grp"><div class="clearfix"><h3>Attribute name</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="tissueGds">tissue</a><span class="fcount">(377)</span></li><li class="fil_val"><a href="#" data-value_id="strainGds">strain</a><span class="fcount">(191)</span></li><li class="more"><a href="#attNameGds_more" data-value_id="fetch_more" data-jigconfig=" hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '300px'">Customize ...</a><div style="display:none;" id="attNameGds_more"></div></li></ul></li></ul><ul class="facet" data-filter_id="pubDatesGds" data-ds="yes" id="_pubDatesGds"><li class="filter_grp"><div class="clearfix"><h3>Publication dates</h3><a href="#" data-value_id="" class="clear clear_hide">clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="d30Gds">30 days</a></li><li class="fil_val"><a href="#" data-value_id="y1Gds">1 year</a></li><li class="daterange"><a id="facet_date_rangepubDatesGds" href="#facet_date_range_divpubDatesGds" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'middle left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '375px'">
|
||
Custom range...</a></li><div id="facet_date_range_divpubDatesGds" style="display:none;" class="facets_dialog"><button class="ui-ncbipopper-close-button ui-ncbipopper-close-button-generated ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-blue" generated="true" role="button" aria-disabled="false"><span class="ui-button-text">x</span></button><h4>Custom date range</h4><div><label class="offscreen_noflow" for="facet_date_st_yearpubDatesGds">Start Year</label><input type="text" size="4" placeholder="YYYY" id="facet_date_st_yearpubDatesGds" value="" class="input_date_ym" /><label class="offscreen_noflow" for="facet_date_st_monthpubDatesGds">Start Month</label><input type="text" size="2" placeholder="MM" id="facet_date_st_monthpubDatesGds" value="" class="input_date_ym" /><label class="offscreen_noflow" for="facet_date_st_daypubDatesGds">Start Day</label><input type="text" size="2" placeholder="DD" id="facet_date_st_daypubDatesGds" value="" /><span>to</span><label class="offscreen_noflow" for="facet_date_end_yearpubDatesGds">End Year</label><input type="text" size="4" placeholder="YYYY" id="facet_date_end_yearpubDatesGds" value="" class="input_date_ym" /><label class="offscreen_noflow" for="facet_date_end_monthpubDatesGds">End Month</label><input type="text" size="2" placeholder="MM" id="facet_date_end_monthpubDatesGds" value="" class="input_date_ym" /><label class="offscreen_noflow" for="facet_date_end_daypubDatesGds">End Day</label><input type="text" size="2" placeholder="DD" id="facet_date_end_daypubDatesGds" value="" /></div><div class="actions clearfix"><button class="jig-ncbibutton primary-action btn_date_apply" data-jigconfig="'color': 'ui-ncbibutton-blue'" id="facet_date_range_applypubDatesGds">Apply</button><button class="jig-ncbibutton secondary-action btn_date_clear" data-jigconfig="'color': 'ui-ncbibutton-gray'" id="facet_date_range_clearpubDatesGds">Clear</button></div></div></ul></li></ul><ul class="facet facet_reset"><li><a href="#" data-value_id="reset">Clear all</a></li></ul><ul class="facet_tools"><li><a id="more_filter_groups_link" href="#more_filter_groups" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'top left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '180px'">
|
||
Show additional filters</a></li><div id="more_filter_groups" style="display:none;" class="facets_dialog"><button class="ui-ncbipopper-close-button ui-ncbipopper-close-button-generated ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-blue" generated="true" role="button" aria-disabled="false"><span class="ui-button-text">x</span></button><h4>Additional filters</h4><ul class="filter_groups_more facet"><li><input type="checkbox" id="fg_entryTypeGds" /><label for="fg_entryTypeGds">Entry type</label></li><li><input type="checkbox" id="fg_organismGds" /><label for="fg_organismGds">Organism</label></li><li><input type="checkbox" id="fg_studyTypeGds" /><label for="fg_studyTypeGds">Study type</label></li><li><input type="checkbox" id="fg_authorGds" /><label for="fg_authorGds">Author</label></li><li><input type="checkbox" id="fg_attNameGds" /><label for="fg_attNameGds">Attribute name</label></li><li><input type="checkbox" id="fg_subVarTypeGds" /><label for="fg_subVarTypeGds">Subset variable type</label></li><li><input type="checkbox" id="fg_pubDatesGds" /><label for="fg_pubDatesGds">Publication dates</label></li><li><input type="checkbox" id="fg_sampleCountGds" /><label for="fg_sampleCountGds">Sample count</label></li><li><input type="checkbox" id="fg_suppFileGds" /><label for="fg_suppFileGds">Supplementary file</label></li><li><input id="fg_field_search" type="checkbox" /><label for="fg_field_search">Search fields</label></li></ul><div class="actions clearfix"><button class="filter_groups_more_apply jig-ncbibutton primary-action" id="filter_groups_apply" data-jigconfig="'color': 'ui-ncbibutton-blue'">Show</button></div></div></ul><input name="EntrezSystem2.PEntrez.Gds.Gds_Facets.FacetsUrlFrag" sid="1" type="hidden" value="filters=" /><input name="EntrezSystem2.PEntrez.Gds.Gds_Facets.FacetSubmitted" sid="1" type="hidden" value="false" /><input name="EntrezSystem2.PEntrez.Gds.Gds_Facets.BMFacets" sid="1" type="hidden" value="" /></div>
|
||
</div>
|
||
<div id="maincontent" class="col seven_col">
|
||
<div class="content">
|
||
<div class="results_settings"><ul class="inline_list left display_settings"><li><a name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.Display" sid="0" href="#" class="jig-ncbipopper" data-jigconfig="triggerPosition : 'bottom center',destPosition : 'top center',destSelector : '#display_settings_menu_report', hasArrow : false,openEvent : 'click',closeEvent : 'click',isTriggerElementCloseClick: false,addCloseButton : false, groupName: 'entrez_pg'" id="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.Display">Summary<span href="#" class="tgt_dark"></span></a></li><li><a name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.Display" sid="0" href="#" class="jig-ncbipopper" data-jigconfig="triggerPosition : 'bottom center',destPosition : 'top center',destSelector : '#display_settings_menu_ps', hasArrow : false,openEvent : 'click',closeEvent : 'click',isTriggerElementCloseClick: false,addCloseButton : false, groupName: 'entrez_pg'" 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type="radio" name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.sSort" sid="1" value="none" id="none" checked="true" /><label for="none">Default order</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.sSort" sid="2" value="NSAMD" id="NSAMD" /><label for="NSAMD">Number of Samples (High to Low)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.sSort" sid="3" value="NSAMA" id="NSAMA" /><label for="NSAMA">Number of Samples (Low to High)</label></li></ul></fieldset></div><button name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.SetDisplay" sid="1" class="button_apply ncbipopper-close-button" style="display:none">Apply</button><h4 class="content_header send_to align_right jig-ncbipopper" id="sendto" data-jigconfig="triggerPosition:'bottom center', destPosition : 'top center',destSelector : '#send_to_menu', hasArrow : false, openEvent : 'click',closeEvent : 'click', isTriggerElementCloseClick: false, addCloseButton:true, groupName: 'entrez_pg', adjustFit:'none'"><a href="#" sourceContent="send_to_menu" class="tgt_dark">Send to:</a><script type="text/javascript">
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||
jQuery(document).ready( function () {
|
||
jQuery("#send_to_menu input[type='radio']").click( function () {
|
||
var selectedValue = jQuery(this).val().toLowerCase();
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||
var selectedDiv = jQuery("#send_to_menu div." + selectedValue);
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if(selectedDiv.is(":hidden")){
|
||
jQuery("#send_to_menu div.submenu:visible").slideUp();
|
||
selectedDiv.slideDown();
|
||
}
|
||
});
|
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|
||
});
|
||
|
||
jQuery("#sendto").bind("ncbipopperclose", function(){
|
||
jQuery("#send_to_menu div.submenu:visible").css("display","none");
|
||
jQuery("#send_to_menu input[type='radio']:checked").attr("checked",false);
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||
});
|
||
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<ul id="msgportlet" class="messages"><li class="warn icon"><span class="icon">Unknown field was ignored: [Function Class].</span></li><li class="info icon"><span class="icon">See the search <a href="/gds/details?querykey=871" name="Details" id="Details">details</a>. </span></li></ul>
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<div><div class="rprt"><div class="rprtnum nohighlight"><label for="UidCheckBox200289730" class="ui-helper-hidden-accessible">Select item 200289730</label><input name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_RVDocSum.uid" sid="1" type="checkbox" id="UidCheckBox200289730" value="200289730" /><span>1.</span></div><div class="rslt"><div class="rsltcont"><p class="title"><a href="/geo/query/acc.cgi?acc=GSE289730" ref="ordinalpos=1&ncbi_uid=200289730&link_uid=200289730">Effect of normal and PDK1-deficient human pluripotent stem cells on gene expression during cardiomyocyte differentiation.</a></p><div class="supp">(Submitter supplied) Cardiac remodeling is the primary factor for the development of ischemic heart failure, which can result from various cardiomyopathies. Pyruvate Dehydrogenase Kinase1 (PDK1) is one of the components of AGC kinase family that maintain mitochondrial metabolism. We here report a PDK1-deficient human cardiac myocyte (CM) model that mimicked the human PDK1 homozygous <b>frameshift</b> mutation and determined the effects of PDK1 dysfunction and its underlying mechanism.<a href="/geo/query/acc.cgi?acc=GSE289730"> more...</a><dl class="details lefty"><dt>Organism: </dt><dd class="lng_ln">Homo sapiens</dd></dl><dl class="details lefty"><dt>Type: </dt><dd class="lng_ln">Expression profiling by high throughput sequencing</dd></dl><dl class="details"><dt>Platform: </dt><dd class="lng_ln"><a href="/geo/query/acc.cgi?acc=GPL24676">GPL24676</a> </dd><dt><a href="/gds/?term=GSE289730[ACCN] AND gsm[ETYP]">6 Samples</a></dt><dd></dd></dl><a href="/geo/download/?acc=GSE289730">Download data: XLSX</a></div><div class="aux"><div class="resc"><span class="src">Series</span><dl class="rprtid"><dt>Accession: </dt><dd>GSE289730</dd></dl><dl class="rprtid"><dt>ID:</dt> <dd>200289730</dd> </dl></div><p class="links nohighlight"></p></div></div></div></div><div class="rprt"><div class="rprtnum nohighlight"><label for="UidCheckBox200288289" class="ui-helper-hidden-accessible">Select item 200288289</label><input name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_RVDocSum.uid" sid="2" type="checkbox" id="UidCheckBox200288289" value="200288289" /><span>2.</span></div><div class="rslt"><div class="rsltcont"><p class="title"><a href="/geo/query/acc.cgi?acc=GSE288289" ref="ordinalpos=2&ncbi_uid=200288289&link_uid=200288289">Study 2- RNA-seq of male KOLF2.2J hiPSC-derived trophoblast cell lines homozygous null for seven different transcription factors</a></p><div class="supp">(Submitter supplied) This study aims to phenotype iPSC-derived trophoblast lines that contain homozygous null alleles for transcription factors expressed within the extra-embryonic lineage, with a focus on differentiation toward either primitive syncytium or extra-embryonic mesenchymal cells, depending on the TF being analyzed. Null alleles were generated using three distinct genetic engineering approaches: full protein coding region deletion (KO), critical exon deletion (CE), and insertion of a premature termination codon with <b>frameshift</b> (PTC+1).<a href="/geo/query/acc.cgi?acc=GSE288289"> more...</a><dl class="details lefty"><dt>Organism: </dt><dd class="lng_ln">Homo sapiens</dd></dl><dl class="details lefty"><dt>Type: </dt><dd class="lng_ln">Expression profiling by high throughput sequencing</dd></dl><dl class="details"><dt>Platform: </dt><dd class="lng_ln"><a href="/geo/query/acc.cgi?acc=GPL34281">GPL34281</a> </dd><dt><a href="/gds/?term=GSE288289[ACCN] AND gsm[ETYP]">82 Samples</a></dt><dd></dd></dl><a href="/geo/download/?acc=GSE288289">Download data: CSV</a></div><div class="aux"><div class="resc"><span class="src">Series</span><dl class="rprtid"><dt>Accession: </dt><dd>GSE288289</dd></dl><dl class="rprtid"><dt>ID:</dt> <dd>200288289</dd> </dl></div><p class="links nohighlight"></p></div></div></div></div><div class="rprt"><div class="rprtnum nohighlight"><label for="UidCheckBox200288287" class="ui-helper-hidden-accessible">Select item 200288287</label><input name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_RVDocSum.uid" sid="3" type="checkbox" id="UidCheckBox200288287" value="200288287" /><span>3.</span></div><div class="rslt"><div class="rsltcont"><p class="title"><a href="/geo/query/acc.cgi?acc=GSE288287" ref="ordinalpos=3&ncbi_uid=200288287&link_uid=200288287">Study 7- RNA-seq of male KOLF2.2J hiPSC-derived differentiated cells for lines in which the original mutation to create null alleles was reverted back to wildtype</a></p><div class="supp">(Submitter supplied) This study aimed to phenotype iPSC-derived cortical brain organoids that contained corrections (reversions to wt) for homozygous null alleles for transcription factor PAX6 and to phenotype iPSC-derived extra-embryonic cell lineages that had contained homozygous null alleles for transcription factors PPARG, EPAS1, GCM1, and GRHL1. The original homozygous mutant lines were created by introducing a premature termination codon and <b>frameshift</b> (PTC+1) approach.<a href="/geo/query/acc.cgi?acc=GSE288287"> more...</a><dl class="details lefty"><dt>Organism: </dt><dd class="lng_ln">Homo sapiens</dd></dl><dl class="details lefty"><dt>Type: </dt><dd class="lng_ln">Expression profiling by high throughput sequencing</dd></dl><dl class="details"><dt>Platform: </dt><dd class="lng_ln"><a href="/geo/query/acc.cgi?acc=GPL34281">GPL34281</a> </dd><dt><a href="/gds/?term=GSE288287[ACCN] AND gsm[ETYP]">36 Samples</a></dt><dd></dd></dl><a href="/geo/download/?acc=GSE288287">Download data: CSV</a></div><div class="aux"><div class="resc"><span class="src">Series</span><dl class="rprtid"><dt>Accession: </dt><dd>GSE288287</dd></dl><dl class="rprtid"><dt>ID:</dt> <dd>200288287</dd> </dl></div><p class="links nohighlight"></p></div></div></div></div><div class="rprt"><div class="rprtnum nohighlight"><label for="UidCheckBox200288286" class="ui-helper-hidden-accessible">Select item 200288286</label><input name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_RVDocSum.uid" sid="4" type="checkbox" id="UidCheckBox200288286" value="200288286" /><span>4.</span></div><div class="rslt"><div class="rsltcont"><p class="title"><a href="/geo/query/acc.cgi?acc=GSE288286" ref="ordinalpos=4&ncbi_uid=200288286&link_uid=200288286">Study 6- RNA-seq of female WIBJ2 hiPSC-derived cortical brain organoids and extra-embryonic lineages homozygous null for five different transcription factors</a></p><div class="supp">(Submitter supplied) This study aimed to phenotype iPSC-derived cortical brain organoids that contain homozygous null alleles for transcription factor PAX6 and to phenotype iPSC-derived extra-embryonic cell lineages that contain homozygous null alleles for transcription factors PPARG, EPAS1, GCM1, and GRHL1. Null alleles were generated by the insertion of a premature termination codon with <b>frameshift</b> (PTC+1). This analysis provided insight into the impact of loss of function for these transcription factors in the respective cell lineages.<dl class="details lefty"><dt>Organism: </dt><dd class="lng_ln">Homo sapiens</dd></dl><dl class="details lefty"><dt>Type: </dt><dd class="lng_ln">Expression profiling by high throughput sequencing</dd></dl><dl class="details"><dt>Platform: </dt><dd class="lng_ln"><a href="/geo/query/acc.cgi?acc=GPL34281">GPL34281</a> </dd><dt><a href="/gds/?term=GSE288286[ACCN] AND gsm[ETYP]">33 Samples</a></dt><dd></dd></dl><a href="/geo/download/?acc=GSE288286">Download data: CSV</a></div><div class="aux"><div class="resc"><span class="src">Series</span><dl class="rprtid"><dt>Accession: </dt><dd>GSE288286</dd></dl><dl class="rprtid"><dt>ID:</dt> <dd>200288286</dd> </dl></div><p class="links nohighlight"></p></div></div></div></div><div class="rprt"><div class="rprtnum nohighlight"><label for="UidCheckBox200287844" class="ui-helper-hidden-accessible">Select item 200287844</label><input name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_RVDocSum.uid" sid="5" type="checkbox" id="UidCheckBox200287844" value="200287844" /><span>5.</span></div><div class="rslt"><div class="rsltcont"><p class="title"><a href="/geo/query/acc.cgi?acc=GSE287844" ref="ordinalpos=5&ncbi_uid=200287844&link_uid=200287844">Study 5- RNA-seq of male KOLF2.2J hiPSC-derived cortical brain organoids and extra-embryonic lineages homozygous null for nine different transcription factors and one RNA splicing factor</a></p><div class="supp">(Submitter supplied) This study aimed to phenotype iPSC-derived cortical brain organoids that contain homozygous null alleles for transcription factors SIX3 and NR2F1 and to phenotype iPSC-derived extra-embryonic cell lineages that contain homozygous null alleles for transcription factors HEY1, HOPX, MAFF, TWIST2, DLX4, DLX5, and DLX6 and the splicing factor MBNL2. Null alleles were generated by the insertion of a premature termination codon with <b>frameshift</b> (PTC+1).<a href="/geo/query/acc.cgi?acc=GSE287844"> more...</a><dl class="details lefty"><dt>Organism: </dt><dd class="lng_ln">Homo sapiens</dd></dl><dl class="details lefty"><dt>Type: </dt><dd class="lng_ln">Expression profiling by high throughput sequencing</dd></dl><dl class="details"><dt>Platform: </dt><dd class="lng_ln"><a href="/geo/query/acc.cgi?acc=GPL34281">GPL34281</a> </dd><dt><a href="/gds/?term=GSE287844[ACCN] AND gsm[ETYP]">48 Samples</a></dt><dd></dd></dl><a href="/geo/download/?acc=GSE287844">Download data: CSV</a></div><div class="aux"><div class="resc"><span class="src">Series</span><dl class="rprtid"><dt>Accession: </dt><dd>GSE287844</dd></dl><dl class="rprtid"><dt>ID:</dt> <dd>200287844</dd> </dl></div><p class="links nohighlight"></p></div></div></div></div><div class="rprt"><div class="rprtnum nohighlight"><label for="UidCheckBox200287843" class="ui-helper-hidden-accessible">Select item 200287843</label><input name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_RVDocSum.uid" sid="6" type="checkbox" id="UidCheckBox200287843" value="200287843" /><span>6.</span></div><div class="rslt"><div class="rsltcont"><p class="title"><a href="/geo/query/acc.cgi?acc=GSE287843" ref="ordinalpos=6&ncbi_uid=200287843&link_uid=200287843">Study 4- RNA-seq of male KOLF2.2J hiPSC-derived cortical brain organoids and extra-embryonic lineages homozygous null for six different transcription factors</a></p><div class="supp">(Submitter supplied) This study aimed to phenotype iPSC-derived cortical brain organoids that contain homozygous null alleles for transcription factors DMRTA1 and TBR1 and to phenotype iPSC-derived extra-embryonic cell lineages that contain homozygous null alleles for transcription factors OVOL1, PITX1, LMO2, and ZBTB7C. Null alleles were generated by the insertion of a premature termination codon with <b>frameshift</b> (PTC+1).<a href="/geo/query/acc.cgi?acc=GSE287843"> more...</a><dl class="details lefty"><dt>Organism: </dt><dd class="lng_ln">Homo sapiens</dd></dl><dl class="details lefty"><dt>Type: </dt><dd class="lng_ln">Expression profiling by high throughput sequencing</dd></dl><dl class="details"><dt>Platform: </dt><dd class="lng_ln"><a href="/geo/query/acc.cgi?acc=GPL34281">GPL34281</a> </dd><dt><a href="/gds/?term=GSE287843[ACCN] AND gsm[ETYP]">28 Samples</a></dt><dd></dd></dl><a href="/geo/download/?acc=GSE287843">Download data: CSV</a></div><div class="aux"><div class="resc"><span class="src">Series</span><dl class="rprtid"><dt>Accession: </dt><dd>GSE287843</dd></dl><dl class="rprtid"><dt>ID:</dt> <dd>200287843</dd> </dl></div><p class="links nohighlight"></p></div></div></div></div><div class="rprt"><div class="rprtnum nohighlight"><label for="UidCheckBox200287558" class="ui-helper-hidden-accessible">Select item 200287558</label><input name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_RVDocSum.uid" sid="7" type="checkbox" id="UidCheckBox200287558" value="200287558" /><span>7.</span></div><div class="rslt"><div class="rsltcont"><p class="title"><a href="/geo/query/acc.cgi?acc=GSE287558" ref="ordinalpos=7&ncbi_uid=200287558&link_uid=200287558">Study 3- RNA-seq of male KOLF2.2J hiPSC-derived cortical brain organoids homozygous null for six different transcription factors</a></p><div class="supp">(Submitter supplied) This study aims to phenotype iPSC-derived cortical brain organoids that contain homozygous null alleles for transcription factors expressed in the early neuroectoderm. Null alleles were generated using three distinct genetic engineering approaches: full coding region deletion (KO), critical exon deletion (CE), and insertion of a premature termination codon with <b>frameshift</b> (PTC+1). RNA-seq data was generated at the indicated day post initiation of differentiation from hiPSCs.<a href="/geo/query/acc.cgi?acc=GSE287558"> more...</a><dl class="details lefty"><dt>Organism: </dt><dd class="lng_ln">Homo sapiens</dd></dl><dl class="details lefty"><dt>Type: </dt><dd class="lng_ln">Expression profiling by high throughput sequencing</dd></dl><dl class="details"><dt>Platform: </dt><dd class="lng_ln"><a href="/geo/query/acc.cgi?acc=GPL34281">GPL34281</a> </dd><dt><a href="/gds/?term=GSE287558[ACCN] AND gsm[ETYP]">174 Samples</a></dt><dd></dd></dl><a href="/geo/download/?acc=GSE287558">Download data: CSV</a></div><div class="aux"><div class="resc"><span class="src">Series</span><dl class="rprtid"><dt>Accession: </dt><dd>GSE287558</dd></dl><dl class="rprtid"><dt>ID:</dt> <dd>200287558</dd> </dl></div><p class="links nohighlight"></p></div></div></div></div><div class="rprt"><div class="rprtnum nohighlight"><label for="UidCheckBox200288317" class="ui-helper-hidden-accessible">Select item 200288317</label><input name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_RVDocSum.uid" sid="8" type="checkbox" id="UidCheckBox200288317" value="200288317" /><span>8.</span></div><div class="rslt"><div class="rsltcont"><p class="title"><a href="/geo/query/acc.cgi?acc=GSE288317" ref="ordinalpos=8&ncbi_uid=200288317&link_uid=200288317">Study 1 and Study 2 - RNA-seq of male KOLF2.2J hiPSC-derived trophoblast cell lines homozygous null for 14 different transcription factors</a></p><div class="supp">(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. This study aims to phenotype iPSC-derived trophoblast lines that contain homozygous null alleles for transcription factors expressed within the extra-embryonic lineage, with a focus on differentiation toward either primitive syncytium or extra-embryonic mesenchymal cells, depending on the TF being analyzed. Null alleles were generated using three distinct genetic engineering approaches: full protein coding region deletion (KO), critical exon deletion (CE), and insertion of a premature termination codon with <b>frameshift</b> (PTC+1).<a href="/geo/query/acc.cgi?acc=GSE288317"> more...</a><dl class="details lefty"><dt>Organism: </dt><dd class="lng_ln">Homo sapiens</dd></dl><dl class="details lefty"><dt>Type: </dt><dd class="lng_ln">Expression profiling by high throughput sequencing</dd></dl><dl class="details"><dt>Platform: </dt><dd class="lng_ln"><a href="/geo/query/acc.cgi?acc=GPL34281">GPL34281</a> </dd><dt><a href="/gds/?term=GSE288317[ACCN] AND gsm[ETYP]">172 Samples</a></dt><dd></dd></dl><a href="/geo/download/?acc=GSE288317">Download data</a></div><div class="aux"><div class="resc"><span class="src">Series</span><dl class="rprtid"><dt>Accession: </dt><dd>GSE288317</dd></dl><dl class="rprtid"><dt>ID:</dt> <dd>200288317</dd> </dl></div><p class="links nohighlight"></p></div></div></div></div><div class="rprt"><div class="rprtnum nohighlight"><label for="UidCheckBox200288288" class="ui-helper-hidden-accessible">Select item 200288288</label><input name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_RVDocSum.uid" sid="9" type="checkbox" id="UidCheckBox200288288" value="200288288" /><span>9.</span></div><div class="rslt"><div class="rsltcont"><p class="title"><a href="/geo/query/acc.cgi?acc=GSE288288" ref="ordinalpos=9&ncbi_uid=200288288&link_uid=200288288">Study 1- RNA-seq of male KOLF2.2J hiPSC-derived trophoblast cell lines homozygous null for seven different transcription factors</a></p><div class="supp">(Submitter supplied) This study aims to phenotype iPSC-derived trophoblast lines that contain homozygous null alleles for transcription factors expressed within the extra-embryonic lineage, with a focus on differentiation toward either primitive syncytium or extra-embryonic mesenchymal cells, depending on the TF being analyzed. Null alleles were generated using three distinct genetic engineering approaches: full protein coding region deletion (KO), critical exon deletion (CE), and insertion of a premature termination codon with <b>frameshift</b> (PTC+1).<a href="/geo/query/acc.cgi?acc=GSE288288"> more...</a><dl class="details lefty"><dt>Organism: </dt><dd class="lng_ln">Homo sapiens</dd></dl><dl class="details lefty"><dt>Type: </dt><dd class="lng_ln">Expression profiling by high throughput sequencing</dd></dl><dl class="details"><dt>Platform: </dt><dd class="lng_ln"><a href="/geo/query/acc.cgi?acc=GPL34281">GPL34281</a> </dd><dt><a href="/gds/?term=GSE288288[ACCN] AND gsm[ETYP]">90 Samples</a></dt><dd></dd></dl><a href="/geo/download/?acc=GSE288288">Download data: CSV</a></div><div class="aux"><div class="resc"><span class="src">Series</span><dl class="rprtid"><dt>Accession: </dt><dd>GSE288288</dd></dl><dl class="rprtid"><dt>ID:</dt> <dd>200288288</dd> </dl></div><p class="links nohighlight"></p></div></div></div></div><div class="rprt"><div class="rprtnum nohighlight"><label for="UidCheckBox200280131" class="ui-helper-hidden-accessible">Select item 200280131</label><input name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_RVDocSum.uid" sid="10" type="checkbox" id="UidCheckBox200280131" value="200280131" /><span>10.</span></div><div class="rslt"><div class="rsltcont"><p class="title"><a href="/geo/query/acc.cgi?acc=GSE280131" ref="ordinalpos=10&ncbi_uid=200280131&link_uid=200280131">dinB_mSTM_ST34</a></p><div class="supp">(Submitter supplied) dinB, also known as dinP in certain bacterial species, was initially discovered in 1980. Wagner et al. found that dinB was a DNA polymerase belonging to the γ family and playing a crucial role in translesion DNA synthesis. This polymerase can insert deoxyribonucleoside triphosphates across replication-blocking lesions that could potentially be lethal. Previous studies have also indicated that dinB is conserved across various bacterial species.<a href="/geo/query/acc.cgi?acc=GSE280131"> more...</a><dl class="details lefty"><dt>Organism: </dt><dd class="lng_ln">Salmonella enterica subsp. enterica serovar Typhimurium</dd></dl><dl class="details lefty"><dt>Type: </dt><dd class="lng_ln">Expression profiling by high throughput sequencing</dd></dl><dl class="details"><dt>Platform: </dt><dd class="lng_ln"><a href="/geo/query/acc.cgi?acc=GPL30218">GPL30218</a> </dd><dt><a href="/gds/?term=GSE280131[ACCN] AND gsm[ETYP]">18 Samples</a></dt><dd></dd></dl><a href="/geo/download/?acc=GSE280131">Download data: CSV</a></div><div class="aux"><div class="resc"><span class="src">Series</span><dl class="rprtid"><dt>Accession: </dt><dd>GSE280131</dd></dl><dl class="rprtid"><dt>ID:</dt> <dd>200280131</dd> </dl></div><p class="links nohighlight"></p></div></div></div></div><div class="rprt"><div class="rprtnum nohighlight"><label for="UidCheckBox200206490" class="ui-helper-hidden-accessible">Select item 200206490</label><input name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_RVDocSum.uid" sid="11" type="checkbox" id="UidCheckBox200206490" value="200206490" /><span>11.</span></div><div class="rslt"><div class="rsltcont"><p class="title"><a href="/geo/query/acc.cgi?acc=GSE206490" ref="ordinalpos=11&ncbi_uid=200206490&link_uid=200206490">Optimised, <b>frameshift</b>-driven design for single-cell CRISPR perturbation screens</a></p><div class="supp">(Submitter supplied) CRISPR-Cas9 has been widely used to functionally interrogate multiple aspects of cellular physiology and pathophysiology from single gene studies to genome-wide screens. Proper design of highly efficient guide RNAs directing the CRISPR genome editing process is critical for success in these types of experiments. Here, we present a pipeline for designing highly efficient loss-of-function guide RNA (gRNA) libraries with improved rates of knock-out efficiency compared to previous guide RNA library designs.<a href="/geo/query/acc.cgi?acc=GSE206490"> more...</a><dl class="details lefty"><dt>Organism: </dt><dd class="lng_ln">Homo sapiens</dd></dl><dl class="details lefty"><dt>Type: </dt><dd class="lng_ln">Expression profiling by high throughput sequencing</dd></dl><dl class="details"><dt>Platform: </dt><dd class="lng_ln"><a href="/geo/query/acc.cgi?acc=GPL24676">GPL24676</a> </dd><dt><a href="/gds/?term=GSE206490[ACCN] AND gsm[ETYP]">4 Samples</a></dt><dd></dd></dl><a href="/geo/download/?acc=GSE206490">Download data: CSV, MTX, TSV</a></div><div class="aux"><div class="resc"><span class="src">Series</span><dl class="rprtid"><dt>Accession: </dt><dd>GSE206490</dd></dl><dl class="rprtid"><dt>ID:</dt> <dd>200206490</dd> </dl></div><p class="links nohighlight"></p></div></div></div></div><div class="rprt"><div class="rprtnum nohighlight"><label for="UidCheckBox200285085" class="ui-helper-hidden-accessible">Select item 200285085</label><input name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_RVDocSum.uid" sid="12" type="checkbox" id="UidCheckBox200285085" value="200285085" /><span>12.</span></div><div class="rslt"><div class="rsltcont"><p class="title"><a href="/geo/query/acc.cgi?acc=GSE285085" ref="ordinalpos=12&ncbi_uid=200285085&link_uid=200285085">mRNA-seq of AID-expressing cells from mice infected with WT or M2.Stop 73.Bla MHV68</a></p><div class="supp">(Submitter supplied) Gammaherpesviruses (GHV) are DNA tumor viruses that establish lifelong latent infections in lymphocytes. For viruses such as Epstein-Barr virus (EBV) and murine gammaherpesvirus 68 (MHV68), this is accomplished through a viral gene-expression program that promotes cellular proliferation and differentiation, especially of germinal center (GC) B cells. Intrinsic host mechanisms to control virus-driven cellular expansion are incompletely defined.<a href="/geo/query/acc.cgi?acc=GSE285085"> more...</a><dl class="details lefty"><dt>Organism: </dt><dd class="lng_ln">Mus musculus</dd></dl><dl class="details lefty"><dt>Type: </dt><dd class="lng_ln">Expression profiling by high throughput sequencing</dd></dl><dl class="details"><dt>Platform: </dt><dd class="lng_ln"><a href="/geo/query/acc.cgi?acc=GPL17021">GPL17021</a> </dd><dt><a href="/gds/?term=GSE285085[ACCN] AND gsm[ETYP]">12 Samples</a></dt><dd></dd></dl><a href="/geo/download/?acc=GSE285085">Download data: TXT</a></div><div class="aux"><div class="resc"><span class="src">Series</span><dl class="rprtid"><dt>Accession: </dt><dd>GSE285085</dd></dl><dl class="rprtid"><dt>ID:</dt> <dd>200285085</dd> </dl></div><p class="links nohighlight"><a class="dblinks" href="/pubmed?LinkName=gds_pubmed&from_uid=200285085" ref="ordinalpos=12">PubMed</a> </p></div></div></div></div><div class="rprt"><div class="rprtnum nohighlight"><label for="UidCheckBox200232415" class="ui-helper-hidden-accessible">Select item 200232415</label><input name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_RVDocSum.uid" sid="13" type="checkbox" id="UidCheckBox200232415" value="200232415" /><span>13.</span></div><div class="rslt"><div class="rsltcont"><p class="title"><a href="/geo/query/acc.cgi?acc=GSE232415" ref="ordinalpos=13&ncbi_uid=200232415&link_uid=200232415">Gene expression alterations with Nkapl knockout or NKAPL <b>frameshift</b> mutation (M349fs)</a></p><div class="supp">(Submitter supplied) This study aims to explore the transcriptomic changes in Nkapl-KO, Sox30-KO and Nkapl TGdel/TGdel mouse testes comparing with their wild-type testes. Fresh testes were collected from 21d wild-type, Nkapl-KO, Sox30-KO and Nkapl TGdel/TGdel mice, respectively.<dl class="details lefty"><dt>Organism: </dt><dd class="lng_ln">Mus musculus</dd></dl><dl class="details lefty"><dt>Type: </dt><dd class="lng_ln">Expression profiling by high throughput sequencing</dd></dl><dl class="details"><dt>Platform: </dt><dd class="lng_ln"><a href="/geo/query/acc.cgi?acc=GPL24247">GPL24247</a> </dd><dt><a href="/gds/?term=GSE232415[ACCN] AND gsm[ETYP]">26 Samples</a></dt><dd></dd></dl><a href="/geo/download/?acc=GSE232415">Download data: CSV</a></div><div class="aux"><div class="resc"><span class="src">Series</span><dl class="rprtid"><dt>Accession: </dt><dd>GSE232415</dd></dl><dl class="rprtid"><dt>ID:</dt> <dd>200232415</dd> </dl></div><p class="links nohighlight"><a class="dblinks" href="/pubmed?LinkName=gds_pubmed&from_uid=200232415" ref="ordinalpos=13">PubMed</a> </p></div></div></div></div><div class="rprt"><div class="rprtnum nohighlight"><label for="UidCheckBox200283188" class="ui-helper-hidden-accessible">Select item 200283188</label><input name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_RVDocSum.uid" sid="14" type="checkbox" id="UidCheckBox200283188" value="200283188" /><span>14.</span></div><div class="rslt"><div class="rsltcont"><p class="title"><a href="/geo/query/acc.cgi?acc=GSE283188" ref="ordinalpos=14&ncbi_uid=200283188&link_uid=200283188">RNA genome expansion up to 64 kb in nidoviruses: role of host, genome segmentation, translation elongation and replicase expression</a></p><div class="supp">(Submitter supplied) Positive-strand RNA viruses of the order Nidovirales have the largest known RNA genomes of vertebrate and invertebrate viruses with 36.7 and 41.1 kb, respectively. The acquisition of a proofreading exoribonuclease (ExoN) locus by an ancestral nidovirus enabled crossing of the 20 kb barrier. Other factors constraining genome expansions in nidoviruses remain poorly defined. Here, we assemble 76 genome sequences of invertebrate nidoviruses from >500.000 published transcriptome experiments and triple the number of known nidoviruses with >36 kb genomes, including the largest known 64 kb RNA genome.<a href="/geo/query/acc.cgi?acc=GSE283188"> more...</a><dl class="details lefty"><dt>Organism: </dt><dd class="lng_ln">Nidovirales</dd></dl><dl class="details lefty"><dt>Type: </dt><dd class="lng_ln">Other</dd></dl><dl class="details"><dt>Platform: </dt><dd class="lng_ln"><a href="/geo/query/acc.cgi?acc=GPL35149">GPL35149</a> </dd><dt><a href="/gds/?term=GSE283188[ACCN] AND gsm[ETYP]">32 Samples</a></dt><dd></dd></dl><a href="/geo/download/?acc=GSE283188">Download data: XML</a></div><div class="aux"><div class="resc"><span class="src">Series</span><dl class="rprtid"><dt>Accession: </dt><dd>GSE283188</dd></dl><dl class="rprtid"><dt>ID:</dt> <dd>200283188</dd> </dl></div><p class="links nohighlight"></p></div></div></div></div><div class="rprt"><div class="rprtnum nohighlight"><label for="UidCheckBox200264311" class="ui-helper-hidden-accessible">Select item 200264311</label><input name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_RVDocSum.uid" sid="15" type="checkbox" id="UidCheckBox200264311" value="200264311" /><span>15.</span></div><div class="rslt"><div class="rsltcont"><p class="title"><a href="/geo/query/acc.cgi?acc=GSE264311" ref="ordinalpos=15&ncbi_uid=200264311&link_uid=200264311">Wildtype and PALS1 knockout MDCKII cells grown under non-confluent and in 3D cyst cultures</a></p><div class="supp">(Submitter supplied) To investigate how gradual differences in the tight junction formation could be linked to an altered gene expression, wildtype and PALS1 knockout cell lines were grown under non-confluent and in 3D cyst cultures. After preparation of the mRNA samples, mRNASeq was performed. Normalized gene expression data was then was analyzed for differentially expressed genes, and GO-Term enrichment studies were used to elucidate involved pathways.<dl class="details lefty"><dt>Organism: </dt><dd class="lng_ln">Canis lupus familiaris</dd></dl><dl class="details lefty"><dt>Type: </dt><dd class="lng_ln">Expression profiling by high throughput sequencing</dd></dl><dl class="details"><dt>Platform: </dt><dd class="lng_ln"><a href="/geo/query/acc.cgi?acc=GPL33053">GPL33053</a> </dd><dt><a href="/gds/?term=GSE264311[ACCN] AND gsm[ETYP]">22 Samples</a></dt><dd></dd></dl><a href="/geo/download/?acc=GSE264311">Download data: TXT</a></div><div class="aux"><div class="resc"><span class="src">Series</span><dl class="rprtid"><dt>Accession: </dt><dd>GSE264311</dd></dl><dl class="rprtid"><dt>ID:</dt> <dd>200264311</dd> </dl></div><p class="links nohighlight"><a class="dblinks" href="/pubmed?LinkName=gds_pubmed&from_uid=200264311" ref="ordinalpos=15">PubMed</a> </p></div></div></div></div><div class="rprt"><div class="rprtnum nohighlight"><label for="UidCheckBox200244468" class="ui-helper-hidden-accessible">Select item 200244468</label><input name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_RVDocSum.uid" sid="16" type="checkbox" id="UidCheckBox200244468" value="200244468" /><span>16.</span></div><div class="rslt"><div class="rsltcont"><p class="title"><a href="/geo/query/acc.cgi?acc=GSE244468" ref="ordinalpos=16&ncbi_uid=200244468&link_uid=200244468">The translational landscape of HIV-1 infected cells reveals key gene regulatory principles</a></p><div class="supp">(Submitter supplied) Human immunodeficiency virus-1 (HIV-1) uses a number of strategies to modulate viral and host gene expression during its life cycle. To characterize the transcriptional and translational landscape of HIV-1 infected cells, we used a combination of ribosome profiling, disome sequencing and RNA sequencing. We show that HIV-1 messenger RNAs are efficiently translated at all stages of infection, despite evidence for a substantial decrease in the translational efficiency of host genes that are implicated in host cell translation.<a href="/geo/query/acc.cgi?acc=GSE244468"> more...</a><dl class="details lefty"><dt>Organism: </dt><dd class="lng_ln">Human immunodeficiency virus 1; Homo sapiens</dd></dl><dl class="details lefty"><dt>Type: </dt><dd class="lng_ln">Expression profiling by high throughput sequencing; Other</dd></dl><dl class="details"><dt><a href="/gds/?term=GSE244468[ACCN] AND gpl[ETYP]">6 related Platforms</a></dt><dd></dd><dt><a href="/gds/?term=GSE244468[ACCN] AND gsm[ETYP]">42 Samples</a></dt><dd></dd></dl><a href="/geo/download/?acc=GSE244468">Download data: BED, CSV, FA, GTF, RC, TXT, XLSX</a></div><div class="aux"><div class="resc"><span class="src">Series</span><dl class="rprtid"><dt>Accession: </dt><dd>GSE244468</dd></dl><dl class="rprtid"><dt>ID:</dt> <dd>200244468</dd> </dl></div><p class="links nohighlight"><a class="dblinks" href="/pubmed?LinkName=gds_pubmed&from_uid=200244468" ref="ordinalpos=16">PubMed</a> </p></div></div></div></div><div class="rprt"><div class="rprtnum nohighlight"><label for="UidCheckBox200215960" class="ui-helper-hidden-accessible">Select item 200215960</label><input name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_RVDocSum.uid" sid="17" type="checkbox" id="UidCheckBox200215960" value="200215960" /><span>17.</span></div><div class="rslt"><div class="rsltcont"><p class="title"><a href="/geo/query/acc.cgi?acc=GSE215960" ref="ordinalpos=17&ncbi_uid=200215960&link_uid=200215960">Subclonal evolution revealed by single-cell profiles of expressed mutations identifies adaptation mechanisms to immunotherapy in melanoma [scRNA-seq]</a></p><div class="supp">(Submitter supplied) Intratumoral heterogeneity (ITH) arises from distinct subclonal expansion following genetic or epigenetic alterations, and profoundly influences how tumors response to their immune microenvironment. Tumor progression trees based on single-cell mutational profiles have made it possible to trace subclonal evolution; however, conventional tree-building methods can incorporate only a limited number of cells and mutations, restricting their application to larger single-cell data.<a href="/geo/query/acc.cgi?acc=GSE215960"> more...</a><dl class="details lefty"><dt>Organism: </dt><dd class="lng_ln">Mus musculus</dd></dl><dl class="details lefty"><dt>Type: </dt><dd class="lng_ln">Expression profiling by high throughput sequencing</dd></dl><dl class="details"><dt>Platform: </dt><dd class="lng_ln"><a href="/geo/query/acc.cgi?acc=GPL24247">GPL24247</a> </dd><dt><a href="/gds/?term=GSE215960[ACCN] AND gsm[ETYP]">192 Samples</a></dt><dd></dd></dl><a href="/geo/download/?acc=GSE215960">Download data: TSV</a></div><div class="aux"><div class="resc"><span class="src">Series</span><dl class="rprtid"><dt>Accession: </dt><dd>GSE215960</dd></dl><dl class="rprtid"><dt>ID:</dt> <dd>200215960</dd> </dl></div><p class="links nohighlight"></p></div></div></div></div><div class="rprt"><div class="rprtnum nohighlight"><label for="UidCheckBox200245743" class="ui-helper-hidden-accessible">Select item 200245743</label><input name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_RVDocSum.uid" sid="18" type="checkbox" id="UidCheckBox200245743" value="200245743" /><span>18.</span></div><div class="rslt"><div class="rsltcont"><p class="title"><a href="/geo/query/acc.cgi?acc=GSE245743" ref="ordinalpos=18&ncbi_uid=200245743&link_uid=200245743">Intracellular expression of a chimeric antigen reverses resistance to cancer immunotherapy</a></p><div class="supp">(Submitter supplied) The interaction of <b>frameshift</b> mutation-derived cancer neoantigens and cancer immunotherapy remains unknown. We found that live cell adjuvant or cDNA transfection in the muscle, which express MHC-class I and class II-restricted non-self-peptides, generated broad-spectrum anti-tumor immunity. Such chimeric peptides did not need to be tumor-neoantigens, but must be in a single chain (complete T cell antigen: CTA).<a href="/geo/query/acc.cgi?acc=GSE245743"> more...</a><dl class="details lefty"><dt>Organism: </dt><dd class="lng_ln">Mus musculus</dd></dl><dl class="details lefty"><dt>Type: </dt><dd class="lng_ln">Expression profiling by high throughput sequencing</dd></dl><dl class="details"><dt>Platform: </dt><dd class="lng_ln"><a href="/geo/query/acc.cgi?acc=GPL30172">GPL30172</a> </dd><dt><a href="/gds/?term=GSE245743[ACCN] AND gsm[ETYP]">4 Samples</a></dt><dd></dd></dl><a href="/geo/download/?acc=GSE245743">Download data: MTX, TSV</a></div><div class="aux"><div class="resc"><span class="src">Series</span><dl class="rprtid"><dt>Accession: </dt><dd>GSE245743</dd></dl><dl class="rprtid"><dt>ID:</dt> <dd>200245743</dd> </dl></div><p class="links nohighlight"></p></div></div></div></div><div class="rprt"><div class="rprtnum nohighlight"><label for="UidCheckBox200263137" class="ui-helper-hidden-accessible">Select item 200263137</label><input name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_RVDocSum.uid" sid="19" type="checkbox" id="UidCheckBox200263137" value="200263137" /><span>19.</span></div><div class="rslt"><div class="rsltcont"><p class="title"><a href="/geo/query/acc.cgi?acc=GSE263137" ref="ordinalpos=19&ncbi_uid=200263137&link_uid=200263137">The tRNA methyltransferase Mettl1 governs ketogenesis through translational regulation and drives metabolic reprogramming in cardiomyocyte maturation</a></p><div class="supp">(Submitter supplied) Following birth, the heart undergoes intricate transitions in response to the altered environment, including shifts in energy metabolism and cytoarchitecture, such as the switch from glucose to lipid utilization and the transformation of fetal-to-adult sarcomeric gene isoforms, all aimed at achieving functional maturation. These adaptations facilitate efficient energy production and cardiac contraction, enabling the heart to effectively pump blood throughout the body.<a href="/geo/query/acc.cgi?acc=GSE263137"> more...</a><dl class="details lefty"><dt>Organism: </dt><dd class="lng_ln">Mus musculus; Rattus norvegicus</dd></dl><dl class="details lefty"><dt>Type: </dt><dd class="lng_ln">Expression profiling by high throughput sequencing; Other</dd></dl><dl class="details"><dt>Platforms: </dt><dd class="lng_ln"><a href="/geo/query/acc.cgi?acc=GPL19057">GPL19057</a> <a href="/geo/query/acc.cgi?acc=GPL32027">GPL32027</a> <a href="/geo/query/acc.cgi?acc=GPL24247">GPL24247</a> </dd><dt><a href="/gds/?term=GSE263137[ACCN] AND gsm[ETYP]">18 Samples</a></dt><dd></dd></dl><a href="/geo/download/?acc=GSE263137">Download data: TXT</a></div><div class="aux"><div class="resc"><span class="src">Series</span><dl class="rprtid"><dt>Accession: </dt><dd>GSE263137</dd></dl><dl class="rprtid"><dt>ID:</dt> <dd>200263137</dd> </dl></div><p class="links nohighlight"><a class="dblinks" href="/pubmed?LinkName=gds_pubmed&from_uid=200263137" ref="ordinalpos=19">PubMed</a> </p></div></div></div></div><div class="rprt"><div class="rprtnum nohighlight"><label for="UidCheckBox200254091" class="ui-helper-hidden-accessible">Select item 200254091</label><input name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_RVDocSum.uid" sid="20" type="checkbox" id="UidCheckBox200254091" value="200254091" /><span>20.</span></div><div class="rslt"><div class="rsltcont"><p class="title"><a href="/geo/query/acc.cgi?acc=GSE254091" ref="ordinalpos=20&ncbi_uid=200254091&link_uid=200254091">The effects of HSP60 chaperone deficiency on zebrafish larvae</a></p><div class="supp">(Submitter supplied) To understand the effects of Hsp60 deficiency in developing vertebrates, we generated CRISPR/Cas9-mediated hspd1 knockout zebrafish lines by targeting exon 2 to induce a <b>frameshift</b> mutation. We selected an allele with a 56 base pair deletion inducing a <b>frameshift</b> mutation leading to loss of protein functions. We examined the transcriptome changes in zebrafish larvae at 5 dpf .<dl class="details lefty"><dt>Organism: </dt><dd class="lng_ln">Danio rerio</dd></dl><dl class="details lefty"><dt>Type: </dt><dd class="lng_ln">Expression profiling by high throughput sequencing</dd></dl><dl class="details"><dt>Platform: </dt><dd class="lng_ln"><a href="/geo/query/acc.cgi?acc=GPL29008">GPL29008</a> </dd><dt><a href="/gds/?term=GSE254091[ACCN] AND gsm[ETYP]">6 Samples</a></dt><dd></dd></dl><a href="/geo/download/?acc=GSE254091">Download data: CSV</a></div><div class="aux"><div class="resc"><span class="src">Series</span><dl class="rprtid"><dt>Accession: </dt><dd>GSE254091</dd></dl><dl class="rprtid"><dt>ID:</dt> <dd>200254091</dd> </dl></div><p class="links nohighlight"><a class="dblinks" href="/pubmed?LinkName=gds_pubmed&from_uid=200254091" ref="ordinalpos=20">PubMed</a> </p></div></div></div></div></div>
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<div class="results_settings bottom"><ul class="inline_list left display_settings"><li><a name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.Display" sid="2" href="#" class="jig-ncbipopper" data-jigconfig="triggerPosition : 'top center',destPosition : 'bottom center',destSelector : '#display_settings_menu_report2', hasArrow : false,openEvent : 'click',closeEvent : 'click',isTriggerElementCloseClick: false,addCloseButton : false, groupName: 'entrez_pg'" id="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.Display">Summary<span href="#" class="tgt_dark"></span></a></li><li><a name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.Display" sid="2" href="#" class="jig-ncbipopper" data-jigconfig="triggerPosition : 'top center',destPosition : 'bottom center',destSelector : '#display_settings_menu_ps2', hasArrow : false,openEvent : 'click',closeEvent : 'click',isTriggerElementCloseClick: false,addCloseButton : false, groupName: 'entrez_pg'" 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for="docsum2">Summary</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.sPresentation2" sid="22" value="docsum" format="text" id="docsumtext2" /><label for="docsumtext2">Summary (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.sPresentation2" sid="23" value="uilist" format="text" id="uilisttext2" /><label for="uilisttext2">Unique Identifier List</label></li></ul></fieldset></div><div id="display_settings_menu_ps2" class="disp_settings tabPopper"><fieldset class="items"><legend>Items per page</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.sPageSize2" sid="11" value="5" id="ps52" /><label for="ps52">5</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.sPageSize2" sid="12" value="10" id="ps102" /><label for="ps102">10</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.sPageSize2" sid="13" value="20" id="ps202" checked="true" /><label for="ps202">20</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.sPageSize2" sid="14" value="50" id="ps502" /><label for="ps502">50</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.sPageSize2" sid="15" value="100" id="ps1002" /><label for="ps1002">100</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.sPageSize2" sid="16" value="200" id="ps2002" /><label for="ps2002">200</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.sPageSize2" sid="17" value="500" id="ps5002" /><label for="ps5002">500</label></li></ul></fieldset></div><div id="display_settings_menu_sort2" class="disp_settings tabPopper"><fieldset class="sort"><legend>Sort by</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.sSort2" sid="11" value="none" id="none2" checked="true" /><label for="none2">Default order</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.sSort2" sid="12" value="NSAMD" id="NSAMD2" /><label for="NSAMD2">Number of Samples (High to Low)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.sSort2" sid="13" value="NSAMA" id="NSAMA2" /><label for="NSAMA2">Number of Samples (Low to High)</label></li></ul></fieldset></div><button name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.SetDisplay" sid="2" class="button_apply ncbipopper-close-button" style="display:none">Apply</button><h4 class="content_header send_to align_right jig-ncbipopper" id="sendto2" data-jigconfig="triggerPosition:'top center', destPosition : 'bottom center',destSelector : '#send_to_menu2', hasArrow : false, openEvent : 'click',closeEvent : 'click', isTriggerElementCloseClick: false, addCloseButton:true, groupName: 'entrez_pg', adjustFit:'none'"><a href="#" sourceContent="send_to_menu2" class="tgt_dark">Send to:</a><script type="text/javascript">
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jQuery(document).ready( function () {
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jQuery("#send_to_menu2 input[type='radio']").click( function () {
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var selectedValue = jQuery(this).val().toLowerCase();
|
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var selectedDiv = jQuery("#send_to_menu2 div." + selectedValue);
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if(selectedDiv.is(":hidden")){
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jQuery("#send_to_menu2 div.submenu:visible").slideUp();
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selectedDiv.slideDown();
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}
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});
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||
});
|
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|
||
jQuery("#sendto2").bind("ncbipopperclose", function(){
|
||
jQuery("#send_to_menu2 div.submenu:visible").css("display","none");
|
||
jQuery("#send_to_menu2 input[type='radio']:checked").attr("checked",false);
|
||
});
|
||
|
||
</script></h4><div id="send_to_menu2" class="tabPopper send_to"><fieldset><legend>Choose Destination</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.SendTo" sid="11" value="File" id="dest_File2" /><label for="dest_File2">File</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.SendTo" sid="12" value="AddToClipboard" id="dest_AddToClipboard2" /><label for="dest_AddToClipboard2">Clipboard</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.SendTo" sid="13" value="AddToCollections" id="dest_AddToCollections2" /><label for="dest_AddToCollections2">Collections</label></li></ul></fieldset><div class="submenu file" id="submenu_File2" style="display: none;"><p id="submenu_File_hint2" class="hidden"></p><ul><li><label for="file_format2">Format</label><select id="file_format2" name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.FFormat2" sid="101"><option value="docsum" format="text" selected="selected">Summary (text)</option><option value="uilist" format="text">Unique Identifier List</option></select></li><li><label for="file_sort2">Sort by</label><select id="file_sort2" name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.FSort2" sid="51"><option value="" selected="selected">Default order</option><option value="NSAMD">Number of Samples (High to Low)</option><option value="NSAMA">Number of Samples (Low to High)</option></select></li></ul><button name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.SendToSubmit" sid="11" class="button_apply file ncbipopper-close-button" type="submit" cmd="File">Create File</button></div><div class="submenu addtoclipboard" id="submenu_AddToClipboard2" style="display: none;"><p id="submenu_AddToClipboard_hint2" class="hidden"></p><button name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.SendToSubmit" sid="12" class="button_apply clipboard ncbipopper-close-button" type="submit" cmd="AddToClipboard">Add to Clipboard</button></div><div class="submenu addtocollections" id="submenu_AddToCollections2" style="display: none;"><p id="submenu_AddToCollections_hint2" class="hidden"></p><button name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_DisplayBar.SendToSubmit" sid="13" class="button_apply collections ncbipopper-close-button" type="submit" cmd="AddToCollections">Add to Collections</button></div></div></div>
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
<div class="no_filters app_msg"><p><strong><a href="/sites/myncbi/gds/filters">Filters: </a></strong><a href="/sites/myncbi/gds/filters">Manage Filters</a></p></div>
|
||
<!-- taxonomy filters -->
|
||
<div id="taxonomy-subset-container" rel="gds"><input name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_MultiItemSupl.Taxport.TxView" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_MultiItemSupl.Taxport.TxListSize" sid="1" type="hidden" value="" /><div style="display:none">db=gds|term=%22frameshift%22[Function%20Class]|query=871|qty=26|blobid=MCID_67c9b90a1a48797f60b1c70f|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?</div><dl style="display:none"><em> </em><a href="javascript:void(0)">Taxonomic Groups</a>
|
||
[<a href="javascript:void(0)" style="text-decoration:underline">List</a>]
|
||
<div class="tree">Tree placeholder</div></dl><dl style="display:none"><em> </em><a href="javascript:void(0)">Top Organisms</a>
|
||
[<a href="javascript:void(0)" style="text-decoration:underline">Tree</a>]
|
||
<dd><div style="display:none" class="taxonomy-subset-list"><a href="javascript:void(0)" class="taxonomy-subset-list-ctrl">More...</a></div><div style="display:none" class="taxonomy-subset-list"><a href="javascript:void(0)" class="taxonomy-subset-list-ctrl">Less...</a></div></dd></dl></div>
|
||
<div class="portlet">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Find related data</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_MultiItemSupl.RelatedDataLinks.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="RelatedDataLinks" id="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_MultiItemSupl.RelatedDataLinks.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul class="related">
|
||
<li>
|
||
<label for="rdDatabase">Database: </label>
|
||
<select name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_MultiItemSupl.RelatedDataLinks.rdDatabase" sid="1" id="rdDatabase">
|
||
<option value="rddbto">Select</option>
|
||
<option value="bioproject">BioProject</option>
|
||
<option value="biosample">BioSample</option>
|
||
<option value="dbvar">dbVar</option>
|
||
<option value="gds">GEO DataSets</option>
|
||
<option value="geoprofiles">GEO Profiles</option>
|
||
<option value="pmc">PMC</option>
|
||
<option value="sra">SRA</option>
|
||
<option value="taxonomy">Taxonomy</option>
|
||
</select>
|
||
</li>
|
||
<li>
|
||
<div id="rdOption" style="display: none;">
|
||
<label for="rdLinkOption">Option: </label>
|
||
<select name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_MultiItemSupl.RelatedDataLinks.rdLinkOption" sid="1" id="rdLinkOption"></select>
|
||
</div>
|
||
</li>
|
||
</ul>
|
||
<p id="rdDescr"></p>
|
||
<button name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_MultiItemSupl.RelatedDataLinks.rdFind" sid="1" id="rdFind" disabled="disabled" class="jig-ncbibutton">Find items</button>
|
||
<input name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Gds_MultiItemSupl.RelatedDataLinks.DbName" sid="1" type="hidden" id="DbName" value="gds" />
|
||
<input type="hidden" id="rdqk" value="" />
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Search details</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Discovery_SearchDetails.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Discovery_SearchDetails" id="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Discovery_SearchDetails.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<textarea name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Discovery_SearchDetails.SearchDetailsTerm" sid="1" class="searchdetails_term" cols="30" rows="5" db="gds">"frameshift"[All Fields]</textarea>
|
||
<div class="buttonwrap">
|
||
<button name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.Discovery_SearchDetails.SearchDetailsQuery" sid="1" class="jig-ncbibutton">Search</button>
|
||
</div>
|
||
<a class="seemore" href="/gds/details?querykey=871" ref="log$=details">
|
||
See more...
|
||
</a>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Important Links</h3>
|
||
</div>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="/geo/">GEO Home</a>
|
||
</li>
|
||
<li>
|
||
<a href="/geo/info/">GEO Documentation</a>
|
||
</li>
|
||
<li>
|
||
<a href="/geo/info/datasets.html">About GEO DataSets</a>
|
||
</li>
|
||
<li>
|
||
<a href="/geo/info/qqtutorial.html">Construct a Query</a>
|
||
</li>
|
||
<li>
|
||
<a href="/geo/info/download.html">Download Options</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Recent activity</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.HistoryDisplay.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="recent_activity" id="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.HistoryDisplay.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<div id="HTDisplay" class="">
|
||
<input name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.HistoryDisplay.Cmd" sid="1" type="hidden" />
|
||
<div class="action">
|
||
<a name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.HistoryDisplay.ClearHistory" sid="1" realname="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.HistoryDisplay.ClearHistory" cmd="ClearHT" href="?cmd=ClearHT&" onclick="return false;" id="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.HistoryDisplay.ClearHistory">
|
||
Clear
|
||
</a>
|
||
<a name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.HistoryDisplay.HistoryToggle" sid="1" realname="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOn" cmd="HTOff" href="?cmd=HTOff&" onclick="return false;" id="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.HistoryDisplay.HistoryToggle">
|
||
Turn Off
|
||
</a>
|
||
<a name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.HistoryDisplay.HistoryToggle" sid="2" realname="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOff" cmd="HTOn" href="?cmd=HTOn&" onclick="return false;" id="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.HistoryDisplay.HistoryToggle">
|
||
Turn On
|
||
</a>
|
||
</div>
|
||
<ul id="activity">
|
||
<li class="ra_qry two_line">
|
||
<a class="htb" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67c9b90a84f3725e592fec75">"frameshift"[All Fields] <span class="number">(979)</span></a>
|
||
<div class="tertiary">GEO DataSets</div>
|
||
</li>
|
||
<li class="ra_qry two_line">
|
||
<a class="htb" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67c9b909a68b6b5afc69f054">"frameshift"[All Fields] AND (alive[prop]) <span class="number">(15486)</span></a>
|
||
<div class="tertiary">Gene</div>
|
||
</li>
|
||
<li class="ra_qry two_line">
|
||
<a class="htb" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67c9b905b15b832ebc059259">"splice 5 snp"[Filter] <span class="number">(0)</span></a>
|
||
<div class="tertiary">MedGen</div>
|
||
</li>
|
||
<li class="ra_qry two_line">
|
||
<a class="htb" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67c9b90284f3725e592fb6e0">"splice 5 snp"[Filter] AND 1[s_discriminator] <span class="number">(0)</span></a>
|
||
<div class="tertiary">dbGaP</div>
|
||
</li>
|
||
</ul>
|
||
<p class="HTOn">Your browsing activity is empty.</p>
|
||
<p class="HTOff">Activity recording is turned off.</p>
|
||
<p id="turnOn" class="HTOff">
|
||
<a name="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.HistoryDisplay.HistoryOn" sid="1" realname="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.HistoryDisplay.HistoryOn" cmd="HTOn" href="?cmd=HTOn&" onclick="return false;" id="EntrezSystem2.PEntrez.Gds.Gds_ResultsPanel.HistoryDisplay.HistoryOn">Turn recording back on</a>
|
||
</p>
|
||
<a class="seemore" href="/sites/myncbi/recentactivity">See more...</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
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|
||
</div>
|
||
|
||
<div id="NCBIFooter_dynamic">
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<div class="breadcrumbs">You are here:
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||
<span id="breadcrumb_text"><a href="/guide/">NCBI</a> > <a href="https://www.ncbi.nlm.nih.gov/guide/genes-expression/">Genes & Expression</a> > Gene Expression Omnibus (GEO) Datasets</span></div>
|
||
<a id="help-desk-link" class="help_desk" href="https://support.ncbi.nlm.nih.gov/ics/support/default.asp?Time=2025-03-06T10:02:34-05:00&Snapshot=%2Fprojects%2FGEO%2FGeoProd@1.27&Host=portal107&ncbi_phid=CE8EC1957C9B6BD100000000004E0047&ncbi_session=CE8B5AF87C7FFCB1_0191SID&from=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fgds%2F&db=gds&Ncbi_App=entrez&Page=docsum&style=classic&deptID=28049&report=docsum&querykey=871&query=%22frameshift%22[Function%20Class];%20Page%20number:%201;%20Page%20size:%2020&term=%22frameshift%22[Function%20Class]" target="_blank">Support Center</a>
|
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<title>LinkedIn</title>
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