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<meta name="description" content="About FLink, a resource of the National Center for Biotechnology Information Structure Group" />
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<meta name="keywords" content="FLink, frequency-weighted links, pathways, genes, proteins, protein sequences, chemicals, biochemical, 3D, 3-D, three-dimensional structures, macromolecular structures, x-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, nucleic acids, DNA, RNA, ligands, bound chemicals, drugs, medicine, Entrez, Molecular Modeling Database (MMDB), Conserved Domains Database (CDD), PubChem, BioSystems Databases, NCBI, National Center for Biotechnology Information" />
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<title>About FLink</title>
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<div style="display: block; margin-bottom: 16.003px;"><p></p><p style="padding: 0.5em 2em; font-size: 16px; text-align: center; background: #F2F281 no-repeat 5px center;">The FLink tool has been retired. Please consider using the Entrez Utility (EUtilties) to create your own scripting solution <a href="/books/NBK25501" class="btn btn-primary">/books/NBK25501</a>.</p><p></p></div>
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<TABLE style="margin:0px 0px 0px 0px;" width="100%" border="0" cellspacing="0" cellpadding="0" bgcolor="#FFFFFF">
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<TR>
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<TD class="DocTitleText" align="left"> <A HREF="../flink.cgi">FLink</A></TD>
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<!-- ===================== GREEN_BUTTONS ====================== -->
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<TD width="350" bgcolor="#FFFFFF">
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<TD class="NavResourceButtonActive" align="center" valign="center" style="white-space: nowrap;"><A href="flink_about.html"> ABOUT </A></TD>
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<TD class="NavResourceButtonInactive" align="center" valign="center" style="white-space: nowrap;"><A href="../flink.cgi"> SEARCH </A></TD>
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<TD class="NavResourceButtonInactive" align="center" valign="center" style="white-space: nowrap;"><A href="flink_how_to.html"> HOW TO </A></TD>
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<TD class="NavResourceButtonInactive" align="center" valign="center" style="white-space: nowrap;"><A href="flink_help.html"> HELP </A></TD>
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<TD class="NavResourceButtonInactive" align="center" valign="center" style="white-space: nowrap;"><A href="flink_faq.html"> FAQ </A></TD>
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<TD class="NavResourceButtonInactive" align="center" valign="center" style="white-space: nowrap;"><A href="flink_news.html"> NEWS </A></TD>
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<!-- TD class="NavResourceButtonInactive" align="center" valign="center" style="white-space: nowrap;"><A href="flink_tools.html"> TOOLS </A></TD -->
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<TD class="NavResourceButtonInactive" align="center" valign="center" style="white-space: nowrap;"><A href="flink_publications.html"> PUBLICATIONS </A></TD>
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<TD class="NavResourceButtonInactive" align="center" valign="center" style="white-space: nowrap;"><A href="../../structure_discover.html"> DISCOVER </A></TD>
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<TD class="SteelBlueCell HeaderText2B" ALIGN="LEFT" VALIGN="TOP">About FLink</TD>
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<TD class="WhiteCell" WIDTH="20" ALIGN="Center" VALIGN="TOP"> </TD>
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<A HREF="../flink.cgi"><IMG SRC="images/flinkicon.png" WIDTH="10" HEIGHT="11" BORDER="0" ALT="FLink icon"> <B>FLink</B></A> is a tool that enables you
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<!-- to start with a batch of records in one database (the "source" database) and then retrieve associated records from another database (the "destination" database) -->
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to traverse from a group of records in a <A HREF="flink_help.html#SourceDatabase">source database</A> (e.g., Proteins) to a <A HREF="flink_help.html#OutputRankedList">ranked list</A> of associated records in a <A HREF="flink_help.html#DestinationDatabase">destination database</A> (e.g., BioSystems).<BR><BR>
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The name "FLink" is based on the German word meaning nimble, swift, agile, reflecting the tool's purpose to process large quantities of input and output (up to 100,000 UIDs in each) in an efficient and meaningful way. The name is also an abbreviation for "<A HREF="flink_help.html#OutputRankedListFrequency"><B>frequency-weighted links</B></A>" because the records in the destination database are ranked by the number of items from the source database to which they are linked, as shown by the "frequency" column in the illustration below.<BR><BR>
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The help document includes a quick start guide that shows the <A HREF="flink_help.html#QuickStart"><B>easy 1-2-3 step</B></A> process for using the tool, and provides additional details about proper formatting of the <A HREF="flink_help.html#Input">(1) input UID list</A> and features of the <A HREF="flink_help.html#InputSummary">(2) review + select display</A> and <A HREF="flink_help.html#Output">(3) output display</A>.<BR><BR>
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Although <A HREF="../flink.cgi"><IMG SRC="images/flinkicon.png" WIDTH="10" HEIGHT="11" BORDER="0" ALT="FLink icon"> <B>FLink</B></A> was initially developed as a companion tool for the <A HREF="/biosystems/">BioSystems database</A> in order to input a list of proteins, genes, or small molecules and retrieve a ranked list of biosystems, it can also be used in a similar way for other types of input and output data, as noted in the list of FLink's <A HREF="flink_help.html#SupportedDatabases">supported databases</A>.
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<!-- =========== CLICKABLE_COLUMN_HEADERS_FOR_ILLUSTRATION =========== -->
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<!-- TABLE width="800" border="0" cellspacing="0" cellpadding="0" class="WhiteCell">
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<TD width="215" style="font: 9pt/20pt Helvetica, Verdana, Arial, Sans-serif;color:#0D3863;" bgcolor="#E8F2EB" align="Center"><A HREF="flink_help.html#Input"><B>1: INPUT</B></A></TD>
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<TD width="20" class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
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<TD width="267" style="font: 9pt/20pt Helvetica, Verdana, Arial, Sans-serif;color:#0D3863;" bgcolor="#E8F2EB" align="Center"><A HREF="flink_help.html#InputSummary"><B>2: REVIEW + SELECT</B></A></TD>
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<TD width="21" class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
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<TD width="287" style="font: 9pt/20pt Helvetica, Verdana, Arial, Sans-serif;color:#0D3863;" bgcolor="#E8F2EB" align="Center"><A HREF="flink_help.html#Output"><B>3: OUTPUT</B></A></TD>
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<TD class="WhiteCell MiniText" ALIGN="Center" VALIGN="TOP"><A HREF="flink_help.html#QuickStart"><IMG src="images/about_flink_protein_biosystems_example.png" width="800" height="400" border="0" align="center" alt="Illustration of the three steps in using FLink: (1) input UIDs for desired starting database, (2) review input list and select destination database, (3) retrieve ranked list of records from destination database. Click on the image to open the help document's quick start guide, which contains a more detailed illustration of the steps."></A></TD>
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<table style="margin:0px 0px 0px 0px;" width="800" border="0" bgcolor="FFFFFF" class="NormalText" cellpadding="0" cellspacing="0">
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<td ALIGN="center" VALIGN="top" class="NormalText">
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<A HREF="flink_help.html#Input"><IMG src="images/about_flink_protein_biosystems_example_step1_input_panel.png" WIDTH="211" HEIGHT="400" border="0" align="center" alt="Step 1 in using FLink: Select a desired starting database and input a list of UIDs. Click on this graphic to read more details about input formats and options."></A>
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<td ALIGN="center" VALIGN="center" class="NormalText">
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<img SRC="images/about_flink_protein_biosystems_example_right_arrow.png" width="22" height="400" border="0">
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<td ALIGN="center" VALIGN="top" class="NormalText">
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<A HREF="flink_help.html#InputSummary"><IMG src="images/about_flink_protein_biosystems_example_step2_review_and_select_panel.png" WIDTH="263" HEIGHT="400" border="0" align="center" alt="Step 2 in using FLink: Review your input list and use the LinkTo menu option to select a destination database. Click on this graphic to read more details about this display, the JobID you'll receive after using the LinkTo option, and folder tab functions."></A>
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<img SRC="images/about_flink_protein_biosystems_example_right_arrow.png" width="22" height="400" border="0">
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<td ALIGN="center" VALIGN="top" class="NormalText">
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<A HREF="flink_help.html#Output"><IMG src="images/about_flink_protein_biosystems_example_step3_output_panel.png" WIDTH="281" HEIGHT="400" border="0" align="center" alt="Step 3 in using FLink: View the output, which displays a ranked list of records from destination database. The frequency column shows the number of items from your input list that are linked to each retrieved record. Click on this graphic to read more details about the output display, its folder tab functions, and options to save the input and/or output list as a CSV file."></A>
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<TD class="SteelBlueCell HeaderText2B" ALIGN="LEFT" VALIGN="TOP">Box 5 Header</TD>
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<TD VALIGN="top" ALIGN="RIGHT"><SPAN CLASS="HELPBAR1" STYLE="color="#646464"">Revised 7 December 2021</SPAN></TD>
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<TD width="25"><IMG SRC="/coreweb/template1/pix/pixel.gif" width="1" height="1" alt="" border=0></TD>
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<!-- ##################### END_EDITABLE_CONTENT ##################### -->
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<script type="text/javascript">doc_tmp.getDocFtr('<A HREF="/research/">Computational Biology Branch</A> > <A HREF="/Structure/index.shtml">Structure Group</A> > <A HREF="/biosystems">Biosystems</A> > <A HREF="../flink.cgi">FLink</A> > About','other');</script>
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<!-- script type="text/javascript">doc_tmp.getDocFtr(' > <A HREF="______">__________</A> > <A HREF="______">__________</A> > <A HREF="______">__________</A> > ___currentpage_____', 'other');</script -->
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