816 lines
161 KiB
HTML
816 lines
161 KiB
HTML
<!DOCTYPE html>
|
|
<html>
|
|
<head>
|
|
<meta content="text/html;charset=UTF-8" http-equiv="Content-Type">
|
|
<meta content="cdd" name="ncbi_app"/>
|
|
<meta content="SARS-CoV-2 models" name="ncbi_pdid"/>
|
|
<meta content="cdd" name="ncbi_db"/>
|
|
<meta content="Conserved Domain Database (CDD) models and 3D protein structures relevant to SARS-CoV-2, the novel coronavirus that causes the COVID-19 pandemic. This is a resource of the National Center of Biotechnology Information (NCBI), National Library of Medicine (NLM)"
|
|
name="description">
|
|
<meta content="proteins, functional, conserved domains, 3D structures, macromolecular structures, severe acute respiratory syndrome coronavirus 2, architecture, coronavirus, pandemic, SARS-CoV-2, COVID-19"
|
|
name="keywords">
|
|
<title>SARS-CoV-2 Conserved Domains and 3D Structures</title>
|
|
<meta content="width=device-width, initial-scale=1" name="viewport">
|
|
<link href="apple-touch-icon.png" rel="apple-touch-icon">
|
|
<link href="favicon.ico" rel="icon shortcut" type="image/x-icon">
|
|
|
|
|
|
<link href="/Structure/shlu/jslibs/uswds/resources/uswds-not-greedy.min.css"
|
|
rel="stylesheet"
|
|
type="text/css">
|
|
<link href="/Structure/shlu/jslibs/uswds/resources/header.min.css" rel="stylesheet"
|
|
type="text/css">
|
|
<link href="/Structure/shlu/jslibs/uswds/resources/footer.min.css" rel="stylesheet"
|
|
type="text/css">
|
|
<link href="/Structure/shlu/jslibs/uswds/resources/form.min.css" rel="stylesheet"
|
|
type="text/css">
|
|
<link href="resources/sheet.css" rel="stylesheet" type="text/css">
|
|
|
|
<style type="text/css">.ncbi-alerts {
|
|
background: none repeat scroll 0 0 #671414;
|
|
color: #fff;
|
|
/*padding: .231em 1.231em;*/
|
|
}
|
|
.ncbi-alerts p {
|
|
color: #fff;
|
|
}
|
|
.ncbi-alerts a, .ncbi-alerts a:visited {
|
|
color: -webkit-link;
|
|
cursor: pointer;
|
|
text-decoration: underline;
|
|
}
|
|
.ncbi-alerts p {
|
|
margin: 1em 0;
|
|
padding: 0 0 0 1.5em;
|
|
}
|
|
.ncbi-alerts p:nth-child(1) {
|
|
/*background-image: url('/core/icons/information.png');*/
|
|
background-position: left top;
|
|
background-repeat: no-repeat
|
|
}
|
|
.ncbi-alerts.subclosed p:nth-child(1) {
|
|
background-image: url('/core/alerts/warning.png');
|
|
}
|
|
.ncbi-alerts.subclosed p {
|
|
padding-left: 2em;
|
|
}
|
|
.ncbi-alerts.pubmed, .ncbi-alerts.pubmed p {
|
|
background-color: #97B0C8;
|
|
color: #000;
|
|
}
|
|
.ncbi-alerts a {
|
|
text-decoration: underline !important;
|
|
}
|
|
.ncbi-alerts.pubmed a, .ncbi-alerts.pubmed a:visited {
|
|
color: #000;
|
|
}
|
|
.ncbi-alerts, .ncbi-alerts p {
|
|
/*background-color: #97B0C8;*/
|
|
color: #000;
|
|
}
|
|
</style>
|
|
<style>
|
|
html {
|
|
font-size: 10px;
|
|
}
|
|
.waffle {
|
|
font-size: 0.9em
|
|
}
|
|
.waffle a {
|
|
color: #0071bc !important;
|
|
text-decoration: none;
|
|
}
|
|
.waffle a:hover,
|
|
.waffle a:active {
|
|
color: #205493 !important;
|
|
text-decoration: underline;
|
|
}
|
|
.waffle a:visited {
|
|
color: #4c2c92 !important;
|
|
}
|
|
.readmore {
|
|
display: inline-block;
|
|
cursor: pointer;
|
|
color: #0071bc;
|
|
text-decoration: underline;
|
|
font-style: italic;
|
|
}
|
|
</style>
|
|
|
|
<!-- end content styles -->
|
|
|
|
</head>
|
|
<body>
|
|
<!--[if lte IE 8]>
|
|
<p class="browsehappy">You are using an <strong>outdated</strong> browser. Please <a href="http://browsehappy.com/">upgrade
|
|
your browser</a> to improve your experience.</p>
|
|
<![endif]-->
|
|
|
|
<!--indicator of global warning insertion-->
|
|
<div id="global_alert" style="display:none"></div>
|
|
|
|
<!-- Manually inserted NCBI message, as this is just an html and did not go through web services of any kind
|
|
<div class="ncbi-alerts nCoV" style="display: block; margin-bottom: 0px;"><p></p><p style="padding: 0.5em 2em; font-size: 12px; text-align: center; background: #FFB6B6 url(/core/icons/exclamation.png) no-repeat 5px center;">COVID-19 is an emerging, rapidly evolving situation.<br>Get the latest public health information from CDC: <a href="https://www.coronavirus.gov">https://www.coronavirus.gov </a>.<br>Get the latest research from NIH: <a href="https://www.nih.gov/coronavirus">https://www.nih.gov/coronavirus</a>.</p><p></p></div>
|
|
-->
|
|
<div class="us">
|
|
<a class="skipnav" href="#maincontent">Skip to main page content</a>
|
|
<header class="ncbi-page-header" role="banner">
|
|
<div class="prefix">
|
|
<span class="nih" title="National Institutes of Health">
|
|
<a href="https://www.nih.gov/" title="To NIH homepage">
|
|
<img style="padding:3px;" alt="NCBI"
|
|
src="/coreutils/nwds/img/logos/AgencyLogo.svg">
|
|
</a>
|
|
</span>
|
|
<span class="nlm">
|
|
<a href="https://www.nlm.nih.gov/" title="To NLM homepage">U.S. National Library of Medicine</a>
|
|
</span>
|
|
</div>
|
|
<div class="ncbi">
|
|
<abbr class="abbr">
|
|
<a href="/" title="To NCBI homepage">NCBI</a>
|
|
</abbr>
|
|
<span class="name">
|
|
<a accesskey="1" href="/" title="To NCBI homepage">National Center for Biotechnology Information</a>
|
|
<a accesskey="0" class="usa-sr-only"
|
|
href="/guide/browsers/#ncbi_accesskeys">Accesskeys</a>
|
|
</span>
|
|
</div>
|
|
</header>
|
|
</div>
|
|
<!-- Start of Real content-->
|
|
<!-- Insert static message blocks here
|
|
<div class="ncbi-alerts null" style="display: block; margin-bottom: 0px;"><p></p><p style="padding: 0.5em 2em; font-size: 12pt; text-align: center; background: #FFB6B6 url(/core/icons/exclamation.png) no-repeat 5px center;">Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.<br>The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit <a href="http://cc.nih.gov">cc.nih.gov</a>.<br>Updates regarding government operating status and resumption of normal operations can be found at <a href="http://USA.gov">USA.gov</a>.</p></div>
|
|
<!-- End of message block---------------->
|
|
<div id="sl-page-content-wrap" class="us">
|
|
<div class="usa-grid-full">
|
|
<br><div class="usa-width-one-whole">Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, also known as 2019 novel coronavirus (2019-nCoV)) is the strain of coronavirus that causes coronavirus disease 2019 (COVID-19), a contagious respiratory illness. Coronaviruses possess the largest genomes among any RNA viruses.
|
|
<div id='mmdb_title_expand' class='mmdb-expand readmore'>read more</div>
|
|
<span id='mmdb_title' style='display:none;'>
|
|
This page summarizes some key features of the SARS-CoV-2 virus, based on NCBI's analysis of the virus's genome sequence. In particular, it lists some important genes that have been identified in the genome, along with the <a href=" /Structure/cdd/cdd_help.shtml"><b>conserved domains</b></a> that have been identified on the transcribed proteins. It also provides links to 3D protein structures, as available. The "SARS Cov-2 structure, representative" column lists 3D structures for CoV-2 protein sequences that are included in the multiple sequence alignment of the conserved domain model. If a CoV-2 protein is not yet available for a given gene, then a link is provided for a representative SARS structure, or for a related coronavirus structure, as available.
|
|
</br></br>The data in the table below are organized to reflect the two major types of genes/proteins on the SARS-CoV-2, which is a positive-sense single-stranded RNA virus.
|
|
</br></br>The genome contains several <b>essential genes</b> that encode the viral proteins <b>necessary for replication, transcription and infectious virus assembly</b>. The essential genes comprise the open reading frames 1a and 1b (ORF1ab) that are translated to produce 16 mature nonstructural proteins (nsp1-nsp16, numbered according to their order from the N-terminus to the C-terminus of the ORF 1 polyproteins) that are involved in viral RNA replication and transcription.
|
|
</br></br>In addition to these genes, SARS-CoV-2 contains <b>genes that encode four structural proteins</b> which are <b>involved in infectious virus assembly: (S)pike, (E)nvelope), (M)embrane, and (N)ucleocapsid) proteins</b>. The N protein holds the RNA genome, and the S, E, and M proteins together create the viral envelope. The spike protein is responsible for allowing the virus to attach to and fuse with the membrane of a host cell. Interspersed between these genes in the coronavirus genome are several other <b>genes called "group-specific or accessory genes" and their gene products are called "accessory proteins"</b> that are dispensable for virus growth in vitro, but may play an important role in modulating the host response to virus infection and thereby, <b>contribute to pathogenesis</b>.
|
|
<div id='mmdb_title_shrink' class='mmdb-shrink readmore'>read less</div>
|
|
</span></div>
|
|
</br>
|
|
<br><div class="usa-width-one-whole" style="margin-top:16px;"><font size=5>SARS-CoV-2-related data provided by the <a href="index.shtml"><b>Protein Domains</b></a> resource</font></div>
|
|
</br>
|
|
<div><table class="waffle" cellspacing="0" cellpadding="0" >
|
|
<thead>
|
|
<tr>
|
|
<th>ORF name</th>
|
|
<th><a href="/cdd/?term=cd21796+OR+cd21516+OR+cd21467+OR+pfam12379+OR+cd21557+OR+cd21562+OR+cd21563+OR+cd21525+OR+cd21466+OR+cd21732+OR+cd21822+OR+cd21814+OR+cd21717+OR+cd21473+OR+pfam16348+OR+cd21666+OR+cd21560+OR+cd21827+OR+cd21831+OR+cd21898+OR+cd21901+OR+cd21591+OR+cd21401+OR+cd21409+OR+cd17934+OR+cd18808+OR+cd21659+OR+cd21171+OR+cd21167+OR+cd21161+OR+cd20762+OR+cd21648+OR+pfam12133+OR+cd21663+OR+cd21623+OR+cd21641+OR+cd21597+OR+cd21624+OR+pfam01401+OR+cd21698+OR+cd22378+OR+cd21531+OR+cd21529+OR+cd21554+OR+cd21595">CDD model</a></th>
|
|
<th>Model name (mouse-over name for description)</th>
|
|
<th><a href="/structure/?term=Severe+acute+respiratory+syndrome+coronavirus+2%5BOrgn%5D">SARS Cov-2 structure</a></th>
|
|
<th><a href="/structure/?term=Severe+acute+respiratory+syndrome-related+coronavirus%5BORGN%5D+NOT+Severe+acute+respiratory+syndrome+coronavirus+2%5BOrgn%5D">SARSr-CoV structure</a></th>
|
|
<th><a href="/structure/?term=Coronaviridae%5BORGN%5D+NOT+Severe+acute+respiratory+syndrome-related+coronavirus%5BORGN%5D">Other coronavirus structure</a></th>
|
|
<th><a href="/protein/?term=Severe+acute+respiratory+syndrome+coronavirus+2%5BORGN%5D+AND+RefSeq%5BFilt%5D">RefSeq protein</a></th>
|
|
<th>Length</th>
|
|
</tr>
|
|
|
|
</thead>
|
|
<tbody>
|
|
<tr>
|
|
<td colspan = 8><b>Non-structural proteins encoded by orf1ab:</b></td>
|
|
</tr>
|
|
|
|
<tr>
|
|
<td colspan = 6>orf1ab</td>
|
|
<td><a href="/protein/YP_009724389.1">YP_009724389</a> [<a href="/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=YP_009724389.1">domain architecture</a>]</td>
|
|
<td>7096</td>
|
|
</tr>
|
|
<tr>
|
|
<td>Nsp1</td>
|
|
<td><a href="/Structure/cdd/cd21796">cd21796</a></td>
|
|
<td><span title="Non structural protein Nsp1. Nsp1 is the N-terminal cleavage product from the viral replicase that mediates RNA replication and processing. The specific function of the protein is unknown however the structure has been determined. The protein has a novel alpha/beta fold formed by a 6 stranded beta barrel with an alpha helix covering one end of the barrel and another helix alongside the barrel. Nsp1 could be involved in the degradation of mRNA.">SARS-CoV-like_Nsp1_N</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/7K3N"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=7K3N" width="82%" height="82%" width="82%" height="82%" alt="Molecular structure image for 7K3N"/><br>7K3N</a> [<a href="/structure/?term=6ZLW+OR+6ZM7+OR+6ZME+OR+6ZMI+OR+6ZMO+OR+6ZN5+OR+6ZOJ+OR+6ZOK+OR+6ZOL+OR+6ZON+OR+6ZP4+OR+7EQ4+OR+7JQB+OR+7JQC+OR+7K3N+OR+7K5I+OR+7K7P+OR+8A4Y+OR+8A55+OR+8AOU+OR+8ASQ+OR+8AYS+OR+8AYW+OR+8AZ8+OR+8AZ9+OR+8CRF+OR+8CRK+OR+8CRM">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/2GDT"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=2GDT" width="82%" height="82%" width="82%" height="82%" alt="Molecular structure image for 2GDT"/><br>2GDT</a> [<a href="/structure/?term=2HSX+OR+2GDT+OR+7OPL">all</a>]</td>
|
|
<td>-</td>
|
|
<td><a href="/protein/YP_009725297.1">YP_009725297</a> [<a href="/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=YP_009725297.1">domain architecture</a>]</td>
|
|
<td>180</td>
|
|
</tr>
|
|
|
|
<tr>
|
|
<td>Nsp2</td>
|
|
<td><a href="/Structure/cdd/cd21516">cd21516</a></td>
|
|
<td><span title="betacoronavirus non-structural protein 2 (Nsp2) similar to SARS-CoV Nsp2, and related proteins from betacoronaviruses in the B lineage. Non-structural proteins (Nsps) from Severe acute respiratory syndrome coronavirus (SARS-CoV) and betacoronaviruses in the sarbecovirus subgenera (B lineage) are encoded in ORF1a and ORF1b. Post infection, the SARS-CoV genomic RNA is released into the cytoplasm of the cell and translated into two long polyproteins (pp), pp1a and pp1ab, which are then autoproteolytically cleaved by two viral proteases Nsp3 and Nsp5 into smaller subunits. Nsp2 is one of these subunits. The functions of Nsp2 remain unknown. Deletion of Nsp2 from the SARS-CoV genome results in only a modest reduction in viral titers. Rather than playing a role in viral replication, SARS-CoV Nsp2 may be involved in altering the host cell environment; it has been shown to interact with two host proteins, prohibitin 1 (PHB1) and PHB2 which have been implicated in cellular functions, including cell-cycle progression, cell migration, cellular differentiation, apoptosis, and mitochondrial biogenesis.">cv_beta_Nsp2_SARS-like</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/7MSW"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=7MSW" width="82%" height="82%" width="82%" height="82%" alt="Molecular structure image for 7MSW"/><br>7MSW</a> [<a href="/structure/?term=7EXM+OR+7MSW+OR+7MSX">all</a>]</td>
|
|
<td>-</td>
|
|
<td>-</td>
|
|
<td><a href="/protein/YP_009725298.1">YP_009725298</a> [<a href="/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=YP_009725298.1">domain architecture</a>]</td>
|
|
<td>638</td>
|
|
</tr>
|
|
|
|
<tr>
|
|
<td>Nsp3</td>
|
|
<td><a href="/Structure/cdd/cd21467">cd21467</a></td>
|
|
<td><span title="first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins.This ubiquitin-like (Ubl) domain (Ubl1) is found at the N-terminus of coronavirus Nsp3, a large multi-functional multi-domain protein which is an essential component of the replication/transcription complex (RTC). The functions of Ubl1 in CoVs are related to single-stranded RNA (ssRNA) binding and to interacting with the nucleocapsid (N) protein. SARS-CoV Ubl1 has been shown to bind ssRNA having AUA patterns, and since the 5'-UTR of the SARS-CoV genome has a number of AUA repeats, it may bind there. In mouse hepatitis virus (MHV), this Ubl1 domain binds the cognate N protein. Adjacent to Ubl1 is a Glu-rich acidic region (also referred to as hypervariable region, HVR); Ubl1 together with HVR has been called Nsp3a. Currently, the function of HVR in CoVs is unknown. This model corresponds to one of two Ubl domains in Nsp3; the other is located N-terminal to the papain-like protease (PLpro) and is not represented by this model.">Ubl1_cv_Nsp3_N-like</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/7KAG"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=7KAG" width="82%" height="82%" width="82%" height="82%" alt="Molecular structure image for 7KAG"/><br>7KAG</a> [<a href="/structure/?term=7KAG+OR+7PKU+OR+7TI9+OR+7WZO">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/2IDY"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=2IDY" width="82%" height="82%" width="82%" height="82%" alt="Molecular structure image for 2IDY"/><br>2IDY</a> [<a href="/structure/?term=2IDY+OR+2GRI">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/2M0A"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=2M0A" width="82%" height="82%" alt="Molecular structure image for 2M0A"/><br>2M0A</a></td>
|
|
<td><a href="/protein/YP_009725299.1">YP_009725299</a> [<a href="/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=YP_009725299.1">domain architecture</a>]</td>
|
|
<td>1945</td>
|
|
</tr>
|
|
<tr>
|
|
<td></td>
|
|
<td><a href="/Structure/cdd/pfam12379">pfam12379</a></td>
|
|
<td><span title="Protein of unknown function (DUF3655). This domain family is found in viruses, and is approximately 70 amino acids in length. The family is found in association with pfam08716, pfam01661, pfam05409, pfam06471, pfam08717, pfam06478, pfam09401, pfam06460, pfam08715, pfam08710.">DUF3655</span></td>
|
|
<td>-</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/2K87"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=2K87" width="82%" height="82%" alt="Molecular structure image for 2K87"/><br>2K87</a></td>
|
|
<td>-</td>
|
|
<td></td>
|
|
<td></td>
|
|
</tr>
|
|
<tr>
|
|
<td></td>
|
|
<td><a href="/Structure/cdd/cd21557">cd21557</a></td>
|
|
<td><span title="X-domain of viral non-structural protein 3 and related macrodomains. The X-domain, a macrodomain, is found in riboviral non-structural protein 3 (Nsp3), including the Nsp3 of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and other coronaviruses (alpha-, beta-, gamma-, and deltacoronavirus), among others. The SARS-CoV X-domain may function as a module binding poly(ADP-ribose), a metabolic product of NAD+ synthesized by poly(ADP-ribose) polymerase (PARP). The X-domain of Avian infectious bronchitis virus (IBV) strain Beaudette coronavirus does not bind ADP-ribose; the triple glycine sequence found in the X-domains of SARS-CoV and human coronavirus 229E (HCoV229E), which are involved in ADP-ribose binding, is not conserved in the IBV X-domain. SARS-CoV has two other macrodomains referred to as the SUD-N (N-terminal subdomain) and SUD-M (middle SUD subdomain) of the SARS-unique domain (SUD), which also do not bind ADP-ribose; these bind G-quadruplexes (unusual nucleic-acid structures formed by consecutive guanosine nucleotides). SARS-CoV SUD-N and SUD-M are not included in this group.">Macro_X_Nsp3-like</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6WEY"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6WEY" width="82%" height="82%" alt="Molecular structure image for 6WEY"/><br>6WEY</a> [<a href="/structure/?term=5RS7+OR+5RS8+OR+5RS9+OR+5RSB+OR+5RSC+OR+5RSD+OR+5RSE+OR+5RSF+OR+5RSG+OR+5RSH+OR+5RSI+OR+5RSJ+OR+5RSK+OR+5RSL+OR+5RSM+OR+5RSN+OR+5RSO+OR+5RSP+OR+5RSQ+OR+5RSR+OR+5RSS+OR+5RST+OR+5RSU+OR+5RSV+OR+5RSW+OR+5RSX+OR+5RSY+OR+5RSZ+OR+5RT0+OR+5RT1+OR+5RT2+OR+5RT3+OR+5RT4+OR+5RT5+OR+5RT6+OR+5RT7+OR+5RT8+OR+5RT9+OR+5RTA+OR+5RTB+OR+5RTC+OR+5RTD+OR+5RTE+OR+5RTF+OR+5RTG+OR+5RTH+OR+5RTI+OR+5RTJ+OR+5RTK+OR+5RTL+OR+5RTM+OR+5RTN+OR+5RTO+OR+5RTP+OR+5RTQ+OR+5RTR+OR+5RTS+OR+5RTT+OR+5RTU+OR+5RTV+OR+5RTW+OR+5RTX+OR+5RTY+OR+5RTZ+OR+5RU0+OR+5RU1+OR+5RU2+OR+5RU3+OR+5RU4+OR+5RU5+OR+5RU6+OR+5RU7+OR+5RU8+OR+5RU9+OR+5RUA+OR+5RUC+OR+5RUD+OR+5RUE+OR+5RUF+OR+5RUG+OR+5RUH+OR+5RUI+OR+5RUJ+OR+5RUK+OR+5RUL+OR+5RUM+OR+5RUN+OR+5RUO+OR+5RUP+OR+5RUQ+OR+5RUR+OR+5RUS+OR+5RUT+OR+5RUU+OR+5RUV+OR+5RUW+OR+5RUX+OR+5RUY+OR+5RUZ+OR+5RV0+OR+5RV1+OR+5RV2+OR+5RV3+OR+5RV4+OR+5RV5+OR+5RV6+OR+5RV7+OR+5RV8+OR+5RV9+OR+5RVA+OR+5RVB+OR+5RVC+OR+5RVD+OR+5RVE+OR+5RVF+OR+5RVG+OR+5RVH+OR+5RVI+OR+5RVJ+OR+5RVK+OR+5RVL+OR+5RVM+OR+5RVN+OR+5RVO+OR+5RVP+OR+5RVQ+OR+5RVR+OR+5RVS+OR+5RVT+OR+5RVU+OR+5RVV+OR+5S18+OR+5S1A+OR+5S1C+OR+5S1E+OR+5S1G+OR+5S1I+OR+5S1K+OR+5S1M+OR+5S1O+OR+5S1Q+OR+5S1S+OR+5S1U+OR+5S1W+OR+5S1Y+OR+5S20+OR+5S22+OR+5S24+OR+5S26+OR+5S27+OR+5S28+OR+5S29+OR+5S2A+OR+5S2B+OR+5S2C+OR+5S2D+OR+5S2E+OR+5S2F+OR+5S2G+OR+5S2H+OR+5S2I+OR+5S2J+OR+5S2K+OR+5S2L+OR+5S2M+OR+5S2N+OR+5S2O+OR+5S2P+OR+5S2Q+OR+5S2R+OR+5S2S+OR+5S2T+OR+5S2U+OR+5S2V+OR+5S2W+OR+5S2X+OR+5S2Y+OR+5S2Z+OR+5S30+OR+5S31+OR+5S32+OR+5S33+OR+5S34+OR+5S35+OR+5S36+OR+5S37+OR+5S38+OR+5S39+OR+5S3A+OR+5S3B+OR+5S3C+OR+5S3D+OR+5S3E+OR+5S3F+OR+5S3G+OR+5S3H+OR+5S3I+OR+5S3J+OR+5S3K+OR+5S3L+OR+5S3M+OR+5S3N+OR+5S3O+OR+5S3P+OR+5S3Q+OR+5S3R+OR+5S3S+OR+5S3T+OR+5S3U+OR+5S3V+OR+5S3W+OR+5S3X+OR+5S3Y+OR+5S3Z+OR+5S40+OR+5S41+OR+5S42+OR+5S43+OR+5S44+OR+5S45+OR+5S46+OR+5S47+OR+5S48+OR+5S49+OR+5S4A+OR+5S4B+OR+5S4C+OR+5S4D+OR+5S4E+OR+5S4F+OR+5S4G+OR+5S4H+OR+5S4I+OR+5S4J+OR+5S4K+OR+5S73+OR+5S74+OR+5SOI+OR+5SOJ+OR+5SOK+OR+5SOL+OR+5SOM+OR+5SON+OR+5SOO+OR+5SOP+OR+5SOQ+OR+5SOR+OR+5SOS+OR+5SOT+OR+5SOU+OR+5SOV+OR+5SOW+OR+5SOX+OR+5SOY+OR+5SOZ+OR+5SP0+OR+5SP1+OR+5SP2+OR+5SP3+OR+5SP4+OR+5SP6+OR+5SP7+OR+5SP8+OR+5SP9+OR+5SPA+OR+5SPB+OR+5SPC+OR+5SPD+OR+5SPE+OR+5SPF+OR+5SPG+OR+5SPH+OR+5SPI+OR+5SPJ+OR+5SPK+OR+5SPL+OR+5SPM+OR+5SPN+OR+5SPO+OR+5SPP+OR+5SPQ+OR+5SPR+OR+5SPS+OR+5SPT+OR+5SPU+OR+5SPV+OR+5SPW+OR+5SPX+OR+5SPY+OR+5SPZ+OR+5SQ0+OR+5SQ1+OR+5SQ2+OR+5SQ3+OR+5SQ4+OR+5SQ5+OR+5SQ6+OR+5SQ7+OR+5SQ8+OR+5SQ9+OR+5SQA+OR+5SQB+OR+5SQC+OR+5SQD+OR+5SQE+OR+5SQF+OR+5SQG+OR+5SQH+OR+5SQI+OR+5SQJ+OR+5SQK+OR+5SQL+OR+5SQM+OR+5SQN+OR+5SQO+OR+5SQP+OR+5SQQ+OR+5SQR+OR+5SQS+OR+5SQT+OR+5SQU+OR+5SQV+OR+5SQW+OR+5SQX+OR+5SQY+OR+5SQZ+OR+5SR0+OR+5SR1+OR+5SR2+OR+5SR3+OR+5SR4+OR+5SR5+OR+5SR6+OR+5SR7+OR+5SR8+OR+5SR9+OR+5SRA+OR+5SRB+OR+5SRC+OR+5SRD+OR+5SRE+OR+5SRF+OR+5SRG+OR+5SRH+OR+5SRI+OR+5SRJ+OR+5SRK+OR+5SRL+OR+5SRM+OR+5SRN+OR+5SRO+OR+5SRP+OR+5SRQ+OR+5SRR+OR+5SRS+OR+5SRT+OR+5SRU+OR+5SRV+OR+5SRW+OR+5SRX+OR+5SRY+OR+5SRZ+OR+5SS0+OR+5SS1+OR+5SS2+OR+5SS3+OR+5SS4+OR+5SS5+OR+5SS6+OR+5SS7+OR+5SS8+OR+5SS9+OR+5SSA+OR+5SSB+OR+5SSC+OR+5SSD+OR+5SSE+OR+5SSF+OR+5SSG+OR+5SSH+OR+5SSI+OR+5SSJ+OR+5SSK+OR+5SSL+OR+5SSM+OR+5SSN+OR+5SSO+OR+5SSP+OR+5SSQ+OR+5SSR+OR+6VXS+OR+6W02+OR+6W6Y+OR+6WCF+OR+6WEN+OR+6WEY+OR+6WOJ+OR+6YWK+OR+6YWL+OR+6YWM+OR+6Z5T+OR+6Z6I+OR+6Z72+OR+7BF3+OR+7BF4+OR+7BF5+OR+7BF6+OR+7C33+OR+7CZ4+OR+7FR0+OR+7FR1+OR+7FR2+OR+7FR3+OR+7FR4+OR+7FR5+OR+7FR6+OR+7FR7+OR+7FR8+OR+7FR9+OR+7FRA+OR+7FRB+OR+7FRC+OR+7FRD+OR+7JME+OR+7KG3+OR+7KQO+OR+7KQP+OR+7KQW+OR+7KR0+OR+7KR1+OR+7KXB+OR+7LG7+OR+7QG7+OR+7TWF+OR+7TWG+OR+7TWH+OR+7TWI+OR+7TWJ+OR+7TWN+OR+7TWO+OR+7TWP+OR+7TWQ+OR+7TWR+OR+7TWS+OR+7TWT+OR+7TWV+OR+7TWW+OR+7TWX+OR+7TWY+OR+7TX0+OR+7TX1+OR+7TX3+OR+7TX4+OR+7TX5+OR+8AZC+OR+8AZD+OR+8C19+OR+8C1A+OR+8ERS+OR+8GIA">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/2FAV"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=2FAV" width="82%" height="82%" alt="Molecular structure image for 2FAV"/><br>2FAV</a> [<a href="/structure/?term=2FAV+OR+2ACF">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/2VRI"> <img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=2VRI" width="82%" height="82%" alt="Molecular structure image for 2VRI"/><br>2VRI</a> [<a href="/structure/?term=2VRI+OR+3EJF+OR+3EJG+OR+3EKE+OR+3ETI+OR+3EW5+OR+3EWO+OR+3EWQ+OR+3EWR+OR+3GPG+OR+3GPO+OR+3GQE+OR+3GQO+OR+4GUA+OR+5DUS+OR+5HIH+OR+5HOL+OR+5IQ5+OR+5ISN+OR+5MQX+OR+5ZU7+OR+5ZU9+OR+5ZUA+OR+5ZUB+OR+6MEA+OR+6MEB+OR+6MEN+OR+6QZU">all</a>]</td>
|
|
<td></td>
|
|
<td></td>
|
|
</tr>
|
|
<tr>
|
|
<td></td>
|
|
<td><a href="/Structure/cdd/cd21562">cd21562</a></td>
|
|
<td><span title="SUD-N macrodomain of the SARS Unique Domain (SUD) of SARS-CoV non-structural protein 3 and related macrodomains. This subfamily includes the macrodomain referred to as SUD-N (N-terminal subdomain) of the SARS-unique domain (SUD) which binds G-quadruplexes (unusual nucleic-acid structures formed by consecutive guanosine nucleotides). It is found in the non-structural protein 3 (Nsp3) of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and highly related coronaviruses. SUD consists of three globular domains separated by short linker peptide segments: SUD-N, SUD-M, and SUD-C. Among these, SUD-N and SUD-M are macrodomains: the SUD-M domain (not represented in this subfamily) is a related macrodomain which also binds G-quadruplexes. SUD-N is specific to the Nsp3 of SARS and betacoronaviruses of the sarbecovirus subgenera (B lineage), while SUD-M is present in most Nsp3 proteins except the Nsp3 from betacoronaviruses of the embecovirus subgenera (A lineage). SUD-C adopts a frataxin-like fold, has structural similarity to DNA-binding domains of DNA-modifying enzymes, binds single-stranded RNA, and regulates the RNA binding behavior of the SUD-M macrodomain. SARS-CoV Nsp3 contains a third macrodomain (the X-domain) which is also not represented in this subfamily. The X-domain may function as a module binding poly(ADP-ribose); however, SUD-N and SUD-M do not bind ADP-ribose, as the triple glycine sequence involved in its binding is not conserved in these.">Macro_cv_SUD-N_Nsp3-like</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/8GQC"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=8GQC" width="82%" height="82%" alt="Molecular structure image for 8GQC"/><br>8GQC</a> [<a href="/structure/?term=8CMF+OR+8GQC+OR+8HBL+OR+8UFM">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/2W2G"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=2W2G" width="82%" height="82%" alt="Molecular structure image for 2W2G"/><br>2W2G</a> [<a href="/structure/?term=2W2G+OR+2WCT+OR+6YXJ">all</a>]</td>
|
|
<td>-</td>
|
|
<td></td>
|
|
<td></td>
|
|
</tr>
|
|
<tr>
|
|
<td></td>
|
|
<td><a href="/Structure/cdd/cd21563">cd21563</a></td>
|
|
<td><span title="SUD-M macrodomain of the SARS Unique Domain (SUD) of SARS-CoV non-structural protein 3 and related macrodomains. This subfamily includes the macrodomain referred to as SUD-M (middle SUD subdomain) of the SARS-unique domain (SUD) which binds G-quadruplexes (unusual nucleic-acid structures formed by consecutive guanosine nucleotides). It is found in non-structural protein 3 (Nsp3) of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and related coronaviruses. SUD consists of three globular domains separated by short linker peptide segments: SUD-N, SUD-M, and SUD-C. Among these, SUD-N and SUD-M are macrodomains: The SUD-N domain (not represented in this subfamily) is a related macrodomain which also binds G-quadruplexes. While SUD-N is specific to the Nsp3 of SARS and betacoronaviruses of the sarbecovirus subgenera (B lineage), SUD-M is present in most Nsp3 proteins except the Nsp3 from betacoronaviruses of the embecovirus subgenera (A lineage). SUD-M, despite its name, is not specific to SARS. SUD-C adopts a frataxin-like fold, has structural similarity to DNA-binding domains of DNA-modifying enzymes, binds single-stranded RNA, and regulates the RNA binding behavior of the SUD-M macrodomain. SARS-CoV Nsp3 contains a third macrodomain (the X-domain) which is also not represented in this subfamily. The X-domain may function as a module binding poly(ADP-ribose); however, SUD-N and SUD-M do not bind ADP-ribose, as the triple glycine sequence involved in its binding is not conserved in these.">Macro_cv_SUD-M_Nsp3-like</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/7XC3"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=7XC3" width="82%" height="82%" alt="Molecular structure image for 7XC3"/><br>7XC3</a> [<a href="/structure/?term=7XC3+OR+7XC4+OR+8GQC+OR+8HBL+OR+8UFM">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/2W2G"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=2W2G" width="82%" height="82%" alt="Molecular structure image for 2W2G"/><br>2W2G</a> [<a href="/structure/?term=2W2G+OR+2WCT+OR+2JZD+OR+2JZE+OR+2JZF+OR+2RNK+OR+2KQV+OR+2KQW">all</a>]</td>
|
|
<td>-</td>
|
|
<td></td>
|
|
<td></td>
|
|
</tr>
|
|
<tr>
|
|
<td></td>
|
|
<td><a href="/Structure/cdd/cd21525">cd21525</a></td>
|
|
<td><span title="C-terminal SARS-Unique Domain (SUD) of non-structural protein 3 (Nsp3) from Severe Acute Respiratory Syndrome coronavirus and related betacoronaviruses in the B lineage. This subfamily contains the SUD-C of Severe Acute Respiratory Syndrome (SARS) coronavirus (CoV) non-structural protein 3 (Nsp3) and other Nsp3s from betacoronaviruses in the sarbecovirus subgenera (B lineage), such as SARS-CoV-2 and related bat CoVs. Non-structural protein 3 (Nsp3) is a large multi-functional multi-domain protein that is an essential component of the replication/transcription complex (RTC), which carries out RNA synthesis, RNA processing, and interference with the host cell innate immune system. Nsp3 of the Severe Acute Respiratory Syndrome (SARS) coronavirus includes a SARS-unique domain (SUD) consisting of three globular domains separated by short linker peptide segments: SUD-N, SUD-M, and SUD-C. SUD-N and SUD-M are macro domains which bind G-quadruplexes (unusual nucleic-acid structures formed by consecutive guanosine nucleotides). The SUD-C domain adopts a frataxin-like fold and has structural similarity to DNA-binding domains of DNA-modifying enzymes. It binds to single-stranded RNA and recognizes purine bases more strongly than pyrimidine bases. SUD-C also regulates the RNA binding behavior of the SUD-M macrodomain.">SUD_C_SARS-CoV_Nsp3</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/7THH"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=7THH" width="82%" height="82%" alt="Molecular structure image for 2KAF"/><br>7THH</a> [<a href="/structure/?term=7THH+OR+7P2O">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/2KAF"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=2KAF" width="82%" height="82%" alt="Molecular structure image for 2KAF"/><br>2KAF</a> [<a href="/structure/?term=2KAF+OR+2KQW+OR+2KQV">all</a>]</td>
|
|
<td>-</td>
|
|
<td></td>
|
|
<td></td>
|
|
</tr><tr>
|
|
<td></td>
|
|
<td><a href="/Structure/cdd/cd21466">cd21466</a></td>
|
|
<td><span title="second ubiquitin-like (Ubl) domain located N-terminal to the coronavirus SARS-CoV papain-like protease (PLpro) domain in the non-structural protein 3 (Nsp3) and related proteins. Severe acute respiratory syndrome coronavirus (SARS-CoV) non-structural proteins (Nsps) are encoded in ORF1a and ORF1b. Post infection, the SARS-CoV genomic RNA is released into the cytoplasm of the cell and translated into two long polyproteins (pps), pp1a and pp1ab. Papain-like protease (PLpro) is one of two SARS-CoV proteases which process these polyproteins; it cleaves pp1a at three sites, releasing Nsp1, Nsp2, and Nsp3. Nsp3 is a large multi-functional multi-domain protein which is an essential component of the replication/transcription complex (RTC). This ubiquitin-like (Ubl) domain (sometimes referred to as Ubl2, the second Ubl domain of Nsp3) is located N-terminal to the PLpro domain of Nsp3. In addition to being a protease, SARS-CoV PLpro is a deubiquitinating enzyme (DUB), and may be involved in subverting cellular ubiquitination machinery to facilitate viral replication. A number of cellular DUBs have a Ubl domain, where it may serve a regulatory function. The exact functional role of this Ubl domain is unclear.">Ubl2_cv_PLpro_N_Nsp3-like</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6W9C"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6W9C" width="82%" height="82%" alt="Molecular structure image for 6W9C"/><br>6W9C</a> [<a href="/structure/?term=6W9C+OR+6WRH+OR+6WUU+OR+6WX4+OR+6WZU+OR+6YVA+OR+7CJD+OR+7CJM+OR+7CMD+OR+7D47+OR+7D6H+OR+7D7T+OR+7JIR+OR+7JIT+OR+7JIV+OR+7JIW+OR+7JN2+OR+7JRN+OR+7KOJ+OR+7KOK+OR+7KOL+OR+7KRX+OR+7NFV">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/2FE8"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=2FE8" width="82%" height="82%" alt="Molecular structure image for 2FE8"/><br>2FE8</a> [<a href="/structure/?term=2FE8+OR+3E9S+OR+3MJ5+OR+4M0W+OR+4OVZ+OR+5E6J+OR+5TL6+OR+5Y3E+OR+5Y3Q">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/4X2Z"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=4X2Z" width="82%" height="82%" alt="Molecular structure image for 4X2Z"/><br>4X2Z</a> [<a href="/structure/?term=4P16+OR+4PT5+OR+4R3D+OR+4REZ+OR+4RF0+OR+4RF1+OR+4RNA+OR+4WUR+OR+4X2Z+OR+4YPT+OR+5BZ0+OR+5V69+OR+5V6A+OR+5W8T+OR+5W8U+OR+5WFI+OR+6L5T">all</a>]</td>
|
|
<td></td>
|
|
<td></td>
|
|
</tr><tr>
|
|
<td></td>
|
|
<td><a href="/Structure/cdd/cd21732">cd21732</a></td>
|
|
<td><span title="Papain like viral protease.This family of viral proteases are similar to the papain protease and are required for proteolytic processing of the replicase polyprotein. The structure of this protein has shown it adopts a fold similar that of de-ubiquitinating enzymes.">betaCoV_PLPro</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6W9C"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6W9C" width="82%" height="82%" alt="Molecular structure image for 6W9C"/><br>6W9C</a> [<a href="/structure/?term=6W9C+OR+6WRH+OR+6WUU+OR+6WX4+OR+6WZU+OR+6XA9+OR+6XAA+OR+6XG3+OR+6YVA+OR+7D47+OR+7D6H+OR+7D7K+OR+7D7L+OR+7D7T+OR+7E35+OR+7JN2+OR+7KOJ+OR+7KOK+OR+7KOL+OR+7KRX+OR+7LBR+OR+7LBS+OR+7LLF+OR+7LLZ+OR+7LOS+OR+7M1Y+OR+7NT4+OR+7OFS+OR+7OFS+OR+7OFT+OR+7OFT+OR+7OFU+OR+7OFU+OR+7QCG+OR+7QCH+OR+7QCI+OR+7QCJ+OR+7QCK+OR+7QCM+OR+7RBR+OR+7RBS+OR+7RZC+OR+7SDR+OR+7SGU+OR+7SGV+OR+7SGW+OR+7SQE+OR+7THH+OR+7TZJ+OR+7UV5+OR+7YBG+OR+8CX9+OR+8EUA+OR+8FWN+OR+8G62">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/2FE8"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=2FE8" width="82%" height="82%" alt="Molecular structure image for 2FE8"/><br>2FE8</a> [<a href="/structure/?term=2FE8+OR+3E9S+OR+3MJ5+OR+4MM3+OR+4M0W+OR+4OVZ+OR+4OW0+OR+5E6J+OR+5TL6+OR+5TL7+OR+5Y3E+OR+5Y3Q+OR+7LFU+OR+7LFV">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/5WFI"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=5WFI" width="82%" height="82%" alt="Molecular structure image for 5WFI"/><br>5WFI</a> [<a href="/structure/?term=5WFI+OR+4PT5+OR+4R3D+OR+4OVZ+OR+4RNA+OR+4P16+OR+4REZ+OR+4RF0+OR+4RF1+OR+4WUR+OR+4YPT+OR+5BZ0+OR+5KO3+OR+5V69+OR+5V6A+OR+5W8T+OR+5W8U+OR+6BI8+OR+6L5T">all</a>]</td>
|
|
<td></td>
|
|
<td></td>
|
|
</tr><tr>
|
|
<td></td>
|
|
<td><a href="/Structure/cdd/cd21822">cd21822</a></td>
|
|
<td><span title="Nucleic acid-binding domain (NAR). This domain, approximately 100 residues in length, is mainly found in Orf1a polyproteins in severe acute respiratory syndrome coronavirus. The global domain of the NAR represents a new fold, with a parallel four-strand beta-sheet holding two alpha-helices of three and four turns that are oriented antiparallel to the beta-strands and a group of residues form a positively charged patch on the protein surface as the binding site responsible for binding affinity for nucleic acids.">SARS-CoV-like_Nsp3_NAB</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/7LGO"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=7LGO" width="82%" height="82%" alt="Molecular structure image for 7LGO"/><br>7LGO</a></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/2K87"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=2K87" width="82%" height="82%" alt="Molecular structure image for 2K87"/><br>2K87</a></td>
|
|
<td>-</td>
|
|
<td></td>
|
|
<td></td>
|
|
</tr><tr>
|
|
<td></td>
|
|
<td><a href="/Structure/cdd/cd21814">cd21814</a></td>
|
|
<td><span title="Betacoronavirus-specific marker of non-structural protein 3 from Severe Acute Respiratory Syndrome-related Coronavirus and Betacoronavirus in the B lineage. This model represents the betacoronavirus-specific marker (betaSM), also called group 2-specific marker (G2M), of non-structural protein 3 (Nsp3) from betacoronavirus in the sarbecovirus subgenus (B lineage), including highly pathogenic human coronaviruses such as Severe acute respiratory syndrome-related coronavirus (SARS-CoV) and SARS-CoV2 (also called 2019 novel CoV or 2019-nCoV). The betaSM/G2M is located C-terminal to the nucleic acid-binding (NAB) domain. This region is absent in alpha- and deltacoronavirus Nsp3; there is a gammacoronavirus-specific marker (gammaSM) at this position in gammacoronavirus Nsp3. Nsp3 is a large multi-functional multi-domain protein that is an essential component of the replication/transcription complex (RTC), which carries out RNA synthesis, RNA processing, and interference with the host cell innate immune system. Little is known about the betaSM/G2M domain; it is predicted to be non-enzymatic and may be an intrinsically disordered region. The betaSM/G2M domain is part of the predicted PLnc domain (made up of 385 amino acids) of SARS-CoV Nsp3 that may function as a replication/transcription scaffold, with interactions to Nsp5, Nsp12, Nsp13, Nsp14, and Nsp16.">SARS-CoV-like_Nsp3_betaSM</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/7T9W"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=7T9W" width="82%" height="82%" alt="Molecular structure image for 7T9W"/><br>7T9W</a></td>
|
|
<td>-</td>
|
|
<td>-</td>
|
|
|
|
<td></td>
|
|
<td></td></tr><tr><td></td>
|
|
<td><a href="/Structure/cdd/cd21717">cd21717</a></td>
|
|
<td><span title="C-terminus of non-structural protein 3, including transmembrane and Y domains, from Severe Acute Respiratory Syndrome-related Coronavirus and Betacoronavirus in the B lineage. This model represents the C-terminus of non-structural protein 3 (Nsp3) from betacoronavirus in the sarbecovirus subgenus (B lineage), including highly pathogenic human coronaviruses such as Severe acute respiratory syndrome-related coronavirus (SARS-CoV) and SARS-CoV2 (also called 2019 novel CoV or 2019-nCoV). This conserved C-terminus includes two transmembrane (TM) regions TM1 and TM2, an ectodomain (3Ecto) between the TM1 and TM2 that is glycosylated and located on the lumenal side of the ER, an amphiphatic region (AH1) that is not membrane-spanning, and a large Y domain of approximately 370 residues. Nsp3 is a large multi-functional multi-domain protein that is an essential component of the replication/transcription complex (RTC), which carries out RNA synthesis, RNA processing, and interference with the host cell innate immune system. In SARS-CoV and the related murine hepatitis virus (MHV), the TM1, 3Ecto and TM2 domains are important for the papain-like protease (PL2pro) domain to process Nsp3-Nsp4 cleavage. It has also been shown that the interaction of 3Ecto with the lumenal loop of Nsp4 is essential for ER rearrangements in cells infected with SARS-CoV or MHV. The Y domain, located at the cytosolic side of the ER, consists of the Y1 and CoV-Y subdomains, which are conserved in nidovirus and coronavirus, respectively. Functional information about the Y domain is limited; it has been shown that Nsp3 binding to Nsp4 is less efficient without the Y domain.">TM_Y_SARS-CoV-like_Nsp3_C</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/7RQG"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=7RQG" width="82%" height="82%" alt="Molecular structure image for 7RQG"/><br>7RQG</a>[<a href="/structure/?term=7RQG+OR+8F2E+OR+8ILC">all</a>]</td>
|
|
<td>-</td>
|
|
<td>-</td>
|
|
<td></td>
|
|
<td></td>
|
|
</tr>
|
|
|
|
<tr>
|
|
<td>Nsp4</td>
|
|
<td><a href="/Structure/cdd/cd21473">cd21473</a></td>
|
|
<td><span title="coronavirus non-structural protein 4 (Nsp4) transmembrane domain. Nsp4 may be involved in coronavirus-induced membrane remodeling. In order to assemble the replication-transcription complex (RTC), coronavirus induces the rearrangement of host endoplasmic reticulum (ER) membrane into double membrane vesicles (DMVs), zippered ER, or ER spherules. DMV formation has been observed in SARS-CoV cells overexpressing the three transmembrane-containing non-structural proteins of viral replicase polyprotein 1ab: Nsp3, Nsp4 and Nsp6. Together, Nsp3, Nsp4, and Nsp6 have the ability to induce the formation of DMVs that are similar to those seen in SARS-CoV-infected cells.">cv_Nsp4_TM</span></td>
|
|
<td>-</td>
|
|
<td>-</td>
|
|
<td>-</td>
|
|
<td><a href="/protein/YP_009725300.1">YP_009725300</a> [<a href="/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=YP_009725300.1">domain architecture</a>]</td>
|
|
<td>500</td></tr><tr><td></td>
|
|
<td><a href="/Structure/cdd/pfam16348">pfam16348</a></td>
|
|
<td><span title="Coronavirus nonstructural protein 4 C-terminus. This is the C-terminal domain of the coronavirus nonstructural protein 4 (NSP4). NSP4 is a membrane-spanning protein which is thought to anchor the viral replication-transcription complex (RTC) to modified endoplasmic reticulum membranes. This predominantly alpha-helical domain may be involved in protein-protein interactions.">Corona_NSP4_C</span></td>
|
|
<td>-</td>
|
|
<td>-</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/3GZF"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=3GZF" width="82%" height="82%" alt="Molecular structure image for 3GZF"/><br>3GZF</a> [<a href="/structure/?term=3GZF+OR+3VCB+OR+3VC8">all</a>]</td>
|
|
<td></td>
|
|
<td></td>
|
|
</tr>
|
|
|
|
<tr>
|
|
<td>Nsp5</td>
|
|
<td><a href="/Structure/cdd/cd21666">cd21666</a></td>
|
|
<td><span title="betacoronavirus non-structural protein 5, also called Main protease (Mpro). This subfamily contains the coronavirus (CoV) non-structural protein 5 (Nsp5) also called the Main protease (Mpro), or 3C-like protease (3CLpro), found in betacoronaviruses. CoVs utilize a multi-subunit replication/transcription machinery. A set of non-structural proteins (Nsps) generated as cleavage products of the ORF1a and ORF1ab viral polyproteins assemble to facilitate viral replication and transcription. Mpro/Nsp5 is a key enzyme in this process, making it a high value target for the development of anti-coronavirus therapeutics. These enzymes belong to the MEROPS peptidase C30 family, where the active site residues His and Cys form a catalytic dyad. The structures of Mpro/Nsp5 consist of three domains with the first two containing anti-parallel beta barrels and the third consisting of an arrangement of alpha-helices. The catalytic residues are found in a cleft between the first two domains. Mpro requires a Gln residue in the P1 position of the substrate and space for only small amino-acid residues such as Gly, Ala, or Ser in the P1' position; since there is no known human protease with a specificity for Gln at the cleavage site of the substrate, these viral proteases are suitable targets for the development of antiviral drugs.">betaCoV_Nsp5_Mpro</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/7BQY"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=7BQY" width="82%" height="82%" alt="Molecular structure image for 7BQY"/><br>7BQY</a> [<a href="/structure/?term=5R7Y+OR+5R7Z+OR+5R80+OR+5R81+OR+5R82+OR+5R83+OR+5R84+OR+5R8T+OR+5RE4+OR+5RE5+OR+5RE6+OR+5RE7+OR+5RE8+OR+5RE9+OR+5REA+OR+5REB+OR+5REC+OR+5RED+OR+5REE+OR+5REF+OR+5REG+OR+5REH+OR+5REI+OR+5REJ+OR+5REK+OR+5REL+OR+5REM+OR+5REN+OR+5REO+OR+5REP+OR+5RER+OR+5RES+OR+5RET+OR+5REU+OR+5REV+OR+5REW+OR+5REX+OR+5REY+OR+5REZ+OR+5RF0+OR+5RF1+OR+5RF2+OR+5RF3+OR+5RF4+OR+5RF5+OR+5RF6+OR+5RF7+OR+5RF8+OR+5RF9+OR+5RFA+OR+5RFB+OR+5RFC+OR+5RFD+OR+5RFE+OR+5RFF+OR+5RFG+OR+5RFH+OR+5RFI+OR+5RFJ+OR+5RFK+OR+5RFL+OR+5RFM+OR+5RFN+OR+5RFO+OR+5RFP+OR+5RFQ+OR+5RFR+OR+5RFS+OR+5RFT+OR+5RFU+OR+5RFV+OR+5RFW+OR+5RFX+OR+5RFY+OR+5RFZ+OR+5RG0+OR+5RG1+OR+5RG2+OR+5RG3+OR+5RGG+OR+5RGH+OR+5RGI+OR+5RGJ+OR+5RGK+OR+5RGL+OR+5RGM+OR+5RGN+OR+5RGO+OR+5RGP+OR+5RGQ+OR+5RGR+OR+5RGS+OR+5RGT+OR+5RGU+OR+5RGV+OR+5RGW+OR+5RGX+OR+5RGY+OR+5RGZ+OR+5RH0+OR+5RH1+OR+5RH2+OR+5RH3+OR+5RH4+OR+5RH5+OR+5RH6+OR+5RH7+OR+5RH8+OR+5RH9+OR+5RHA+OR+5RHB+OR+5RHC+OR+5RHD+OR+5RHE+OR+5RHF+OR+5RL0+OR+5RL1+OR+5RL2+OR+5RL3+OR+5RL4+OR+5RL5+OR+5SML+OR+5SMM+OR+5SMN+OR+6LU7+OR+6LZE+OR+6M03+OR+6M0K+OR+6M2N+OR+6M2Q+OR+6W63+OR+6W79+OR+6WNP+OR+6WQF+OR+6WTJ+OR+6WTK+OR+6WTM+OR+6WTT+OR+6XA4+OR+6XB0+OR+6XB1+OR+6XB2+OR+6XBG+OR+6XBH+OR+6XBI+OR+6XCH+OR+6XFN+OR+6XHM+OR+6XHU+OR+6XKF+OR+6XKH+OR+6XMK+OR+6XOA+OR+6XQS+OR+6XQT+OR+6XQU+OR+6XR3+OR+6Y2E+OR+6Y2F+OR+6Y2G+OR+6Y84+OR+6YB7+OR+6YNQ+OR+6YT8+OR+6YVF+OR+6YZ6+OR+6Z2E+OR+6ZRT+OR+6ZRU+OR+7A1U+OR+7ABU+OR+7ADW+OR+7AEG+OR+7AEH+OR+7AF0+OR+7AGA+OR+7AHA+OR+7AK4+OR+7AK4+OR+7AKU+OR+7ALH+OR+7ALI+OR+7AMJ+OR+7ANS+OR+7AOL+OR+7AP6+OR+7APH+OR+7APH+OR+7AQE+OR+7AQI+OR+7AQJ+OR+7AR5+OR+7AR6+OR+7ARF+OR+7AU4+OR+7AVD+OR+7AWR+OR+7AWS+OR+7AWU+OR+7AWW+OR+7AX6+OR+7AXM+OR+7AXO+OR+7AY7+OR+7B2J+OR+7B2U+OR+7B3E+OR+7B5Z+OR+7B77+OR+7B83+OR+7BAJ+OR+7BAK+OR+7BAL+OR+7BB2+OR+7BE7+OR+7BFB+OR+7BGP+OR+7BIJ+OR+7BQY+OR+7BRO+OR+7BRP+OR+7BRR+OR+7BUY+OR+7C2Q+OR+7C2Y+OR+7C6S+OR+7C6U+OR+7C7P+OR+7C8B+OR+7C8R+OR+7C8T+OR+7C8U+OR+7CA8+OR+7CAM+OR+7CB7+OR+7CBT+OR+7COM+OR+7CUT+OR+7CUU+OR+7CWB+OR+7CWC+OR+7CX9+OR+7D1M+OR+7D1O+OR+7D3I+OR+7D64+OR+7DAT+OR+7DAU+OR+7DAV+OR+7DDC+OR+7DG6+OR+7DGB+OR+7DGF+OR+7DGG+OR+7DGH+OR+7DGI+OR+7DHJ+OR+7DJR+OR+7DK1+OR+7DPP+OR+7DPU+OR+7DPV+OR+7DVP+OR+7DVW+OR+7DVX+OR+7DVY+OR+7DW0+OR+7DW6+OR+7E18+OR+7E19+OR+7E5X+OR+7E6K+OR+7EIN+OR+7EN8+OR+7EN9+OR+7FAY+OR+7FAZ+OR+7JFQ+OR+7JKV+OR+7JMW+OR+7JOX+OR+7JOY+OR+7JP0+OR+7JP1+OR+7JPY+OR+7JPZ+OR+7JQ0+OR+7JQ1+OR+7JQ2+OR+7JQ3+OR+7JQ4+OR+7JQ5+OR+7JR3+OR+7JR4+OR+7JST+OR+7JSU+OR+7JT0+OR+7JT7+OR+7JU7+OR+7JUN+OR+7JVZ+OR+7JW8+OR+7JYC+OR+7K0E+OR+7K0F+OR+7K3T+OR+7K40+OR+7K6D+OR+7K6E+OR+7KFI+OR+7KFJ+OR+7KHP+OR+7KPH+OR+7KS5+OR+7KVG+OR+7KVL+OR+7KVR+OR+7KW5+OR+7KX5+OR+7KYU+OR+7L0D+OR+7L10+OR+7L11+OR+7L12+OR+7L13+OR+7L14+OR+7L5D+OR+7L8I+OR+7L8J+OR+7LB7+OR+7LBN+OR+7LCO+OR+7LCR+OR+7LCS+OR+7LCT+OR+7LDL+OR+7LDX+OR+7LFE+OR+7LFP+OR+7LKD+OR+7LKE+OR+7LKR+OR+7LKS+OR+7LKT+OR+7LKU+OR+7LKV+OR+7LKW+OR+7LKX+OR+7LMC+OR+7LMD+OR+7LME+OR+7LMF+OR+7LTJ+OR+7LTN+OR+7LYH+OR+7LYI+OR+7LZT+OR+7LZU+OR+7LZV+OR+7LZW+OR+7LZX+OR+7LZY+OR+7LZZ+OR+7M00+OR+7M01+OR+7M02+OR+7M03+OR+7M04+OR+7M2P+OR+7M8M+OR+7M8N+OR+7M8O+OR+7M8P+OR+7M8X+OR+7M8Y+OR+7M8Z+OR+7M90+OR+7M91+OR+7MAT+OR+7MAU+OR+7MAV+OR+7MAW+OR+7MAX+OR+7MAZ+OR+7MB0+OR+7MB1+OR+7MB2+OR+7MB3+OR+7MB4+OR+7MB5+OR+7MB6+OR+7MB7+OR+7MB8+OR+7MB9+OR+7MBG+OR+7MBI+OR+7MGR+OR+7MGS+OR+7MHF+OR+7MHG+OR+7MHH+OR+7MHI+OR+7MHJ+OR+7MHK+OR+7MHL+OR+7MHM+OR+7MHN+OR+7MHO+OR+7MHP+OR+7MHQ+OR+7MLF+OR+7MLG+OR+7MNG+OR+7MPB+OR+7MRR+OR+7N44+OR+7N5Z+OR+7N6N+OR+7N89+OR+7N8C+OR+7NBR+OR+7NBS+OR+7NBT+OR+7NBY+OR+7NEO+OR+7NEV+OR+7NF5+OR+7NG3+OR+7NG6+OR+7NIJ+OR+7NT1+OR+7NT2+OR+7NT3+OR+7NTQ+OR+7NTS+OR+7NTT+OR+7NTV+OR+7NTW+OR+7NUK+OR+7NW2+OR+7NWX+OR+7NXH+OR+7O46+OR+7P2G+OR+7P35+OR+7P51+OR+7PFL+OR+7PFM+OR+7PHZ+OR+7PXZ+OR+7PZQ+OR+7Q5E+OR+7Q5F+OR+7QBB+OR+7QKA+OR+7QL8+OR+7QT5+OR+7QT6+OR+7QT7+OR+7QT8+OR+7R7H+OR+7RBZ+OR+7RC0+OR+7RFR+OR+7RFS+OR+7RFU+OR+7RFW+OR+7RLS+OR+7RM2+OR+7RMB+OR+7RME+OR+7RMT+OR+7RMZ+OR+7RN0+OR+7RN1+OR+7RN4+OR+7RNH+OR+7RNK+OR+7RNW+OR+7RVM+OR+7RVN+OR+7RVO+OR+7RVP+OR+7RVQ+OR+7RVR+OR+7RVS+OR+7RVT+OR+7RVU+OR+7RVV+OR+7RVW+OR+7RVX+OR+7RVY+OR+7RVZ+OR+7RW0+OR+7RW1+OR+7S3K+OR+7S3S+OR+7S4B+OR+7S6W+OR+7S6X+OR+7S6Y+OR+7S6Z+OR+7S70+OR+7S71+OR+7S72+OR+7S73+OR+7S74+OR+7S75+OR+7S82+OR+7SD9+OR+7SD9+OR+7SDA+OR+7SDA+OR+7SDC+OR+7SDC+OR+7SET+OR+7SF1+OR+7SF3+OR+7SFB+OR+7SFH+OR+7SFI+OR+7SGH+OR+7SH7+OR+7SH8+OR+7SH9+OR+7SI9+OR+7T2T+OR+7T2U+OR+7T2V+OR+7T42+OR+7T43+OR+7T44+OR+7T45+OR+7T46+OR+7T48+OR+7T49+OR+7T4A+OR+7T4B+OR+7T70+OR+7T8M+OR+7T8R+OR+7T9Y+OR+7TA4+OR+7TA7+OR+7TB2+OR+7TBT+OR+7TC4+OR+7TDU+OR+7TE0+OR+7TEH+OR+7TEK+OR+7TEL+OR+7TFR+OR+7TGR+OR+7TIA+OR+7TIU+OR+7TIV+OR+7TIW+OR+7TIX+OR+7TIY+OR+7TIZ+OR+7TJ0+OR+7TLL+OR+7TOB+OR+7TQ2+OR+7TQ3+OR+7TQ4+OR+7TQ5+OR+7TQ6+OR+7TUU+OR+7TVX+OR+7U28+OR+7U29+OR+7U92+OR+7UJ9+OR+7UJG+OR+7UJU+OR+7UKK+OR+7UR9+OR+7URB+OR+7US4+OR+7UU6+OR+7UU7+OR+7UU8+OR+7UU9+OR+7UUA+OR+7UUB+OR+7UUC+OR+7UUD+OR+7UUE+OR+7UUG+OR+7UUP+OR+7V1T+OR+7V7M+OR+7VAH+OR+7VFA+OR+7VFB+OR+7VH8+OR+7VIC+OR+7VJW+OR+7VJX+OR+7VJY+OR+7VJZ+OR+7VK0+OR+7VK1+OR+7VK2+OR+7VK3+OR+7VK4+OR+7VK5+OR+7VK6+OR+7VK7+OR+7VK8+OR+7VLP+OR+7VLQ+OR+7VTH+OR+7VU6+OR+7VVP+OR+7VVT+OR+7VXB+OR+7W9G+OR+7WHC+OR+7WO1+OR+7WO2+OR+7WO3+OR+7WOF+OR+7WOH+OR+7WQ8+OR+7WQ9+OR+7WQA+OR+7WQB+OR+7WQK+OR+7WYM+OR+7WYP+OR+7X6J+OR+7X6K+OR+7XAR+OR+7XAR+OR+7XB3+OR+7XB4+OR+7XQ6+OR+7XQ7+OR+7Z0P+OR+7Z2K+OR+7Z3U+OR+7Z4S+OR+7Z59+OR+7ZB6+OR+7ZB7+OR+7ZB8+OR+7ZQV+OR+7ZV5+OR+7ZV7+OR+7ZV8+OR+8A4Q+OR+8A4T+OR+8ACD+OR+8AEB+OR+8AIQ+OR+8AIU+OR+8AIV+OR+8AIZ+OR+8AJ0+OR+8B0S+OR+8B0T+OR+8B2T+OR+8CYU+OR+8CYZ+OR+8CZ4+OR+8CZ7+OR+8CZW+OR+8CZX+OR+8D35+OR+8D4J+OR+8D4K+OR+8D4L+OR+8D4M+OR+8D4N+OR+8D4P+OR+8DCZ+OR+8DD1+OR+8DD9+OR+8DDI+OR+8DDL+OR+8DDM+OR+8DFE+OR+8DFN+OR+8DG3+OR+8DGB+OR+8DI3+OR+8DIB+OR+8DIC+OR+8DID+OR+8DIE+OR+8DIF+OR+8DIG+OR+8DIH+OR+8DII+OR+8DJJ+OR+8DK8+OR+8DKH+OR+8DKJ+OR+8DKK+OR+8DKL+OR+8DKZ+OR+8DL9+OR+8DLB+OR+8DMD+OR+8DMN+OR+8DOX+OR+8DOY+OR+8DPR+OR+8DRR+OR+8DRS+OR+8DRT+OR+8DRU+OR+8DRV+OR+8DRW+OR+8DRX+OR+8DRY+OR+8DRZ+OR+8DS0+OR+8DS1+OR+8DS2+OR+8DSU+OR+8DZ0+OR+8DZ1+OR+8DZ2+OR+8DZ6+OR+8DZ9+OR+8DZA+OR+8DZB+OR+8DZC+OR+8E1Y+OR+8E25+OR+8E26+OR+8E4J+OR+8E4R+OR+8E5X+OR+8E5Z+OR+8E61+OR+8E63+OR+8E64+OR+8E65+OR+8E68+OR+8E69+OR+8E6A+OR+8EHJ+OR+8EHK+OR+8EHL+OR+8EHM+OR+8EIR+OR+8EJ7+OR+8EJ9+OR+8EKE+OR+8EOY+OR+8EY2+OR+8EYJ+OR+8EZV+OR+8EZZ+OR+8F02+OR+8F2C+OR+8F2D+OR+8F44+OR+8F45+OR+8F46+OR+8FIV+OR+8FIW+OR+8FY6+OR+8FY7+OR+8GFK+OR+8GFN+OR+8GFO+OR+8GFR+OR+8GFU+OR+8GQT+OR+8GTV+OR+8GTW+OR+8GW4+OR+8GWS+OR+8GXG+OR+8GXH+OR+8GXI+OR+8GZB+OR+8H3G+OR+8H3K+OR+8H3L+OR+8H4Y+OR+8H51+OR+8H57+OR+8H5F+OR+8H5P+OR+8H6I+OR+8H6N+OR+8H7K+OR+8H7W+OR+8H82+OR+8HBK+OR+8HEF+OR+8HHT+OR+8HHU+OR+8HTV+OR+8HUR+OR+8HUV+OR+8HUW+OR+8HUX+OR+8I30+OR+8IFP+OR+8IFQ+OR+8IFR+OR+8IFS+OR+8IFT+OR+8IGN+OR+8IGO+OR+8IGX+OR+8IGY+OR+8JOP+OR+8JPQ+OR+8OKK+OR+8OKL+OR+8OKM+OR+8OKN+OR+8SG6+OR+8SK4+OR+8SKH+OR+8SPJ+OR+8STY+OR+8STZ+OR+8SXO+OR+8SXR+OR+8TBE">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/1WOF"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=1WOF" width="82%" height="82%" alt="Molecular structure image for 1WOF"/><br>1WOF</a> [<a href="/structure/?term=1Q2W+OR+1UJ1+OR+1UK2+OR+1UK3+OR+1UK4+OR+1WOF+OR+1Z1I+OR+1Z1J+OR+2A5A+OR+2A5I+OR+2A5K+OR+2ALV+OR+2AMD+OR+2AMQ+OR+2BX3+OR+2BX4+OR+2C3S+OR+2D2D+OR+2DUC+OR+2GT7+OR+2GT8+OR+2GTB+OR+2GX4+OR+2GZ7+OR+2GZ8+OR+2GZ9+OR+2H2Z+OR+2HOB+OR+2K7X+OR+2LIZ+OR+2OP9+OR+2PWX+OR+2Q6G+OR+2QC2+OR+2QCY+OR+2QIQ+OR+2V6N+OR+2VJ1+OR+2Z3C+OR+2Z3D+OR+2Z3E+OR+2Z94+OR+2Z9G+OR+2Z9J+OR+2Z9K+OR+2Z9L+OR+2ZU4+OR+2ZU5+OR+3ATW+OR+3AVZ+OR+3AW0+OR+3AW1+OR+3D62+OR+3E91+OR+3EA7+OR+3EA8+OR+3EA9+OR+3EAJ+OR+3EBN+OR+3F9E+OR+3F9F+OR+3F9G+OR+3F9H+OR+3FZD+OR+3IWM+OR+3M3S+OR+3M3T+OR+3M3V+OR+3SN8+OR+3SNA+OR+3SNB+OR+3SNC+OR+3SND+OR+3SNE+OR+3SZN+OR+3TIT+OR+3TIU+OR+3TNS+OR+3TNT+OR+3V3M+OR+3VB3+OR+3VB4+OR+3VB5+OR+3VB6+OR+3VB7+OR+4HI3+OR+4MDS+OR+4TWW+OR+4TWY+OR+4WY3+OR+5B6O+OR+5C5N+OR+5C5O+OR+5N19+OR+5N5O+OR+6LNQ+OR+6LNY+OR+6LO0+OR+6W2A+OR+6WCO+OR+6XHL+OR+6XHN+OR+6XHO+OR+6Y7M+OR+7DQZ+OR+7EO8+OR+7K0G+OR+7K0H+OR+7LCP+OR+7LCQ+OR+7LMG+OR+7LMH+OR+7LMI+OR+7LMJ+OR+7RC1+OR+7VLO">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/3D23"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=3D23" width="82%" height="82%" alt="Molecular structure image for 3D23"/><br>3D23</a> [<a href="/structure/?term=1LVO+OR+1P9S+OR+2AMP+OR+2Q6D+OR+2Q6G+OR+2YNA+OR+2YNB+OR+2ZU2+OR+3D23+OR+4RSP+OR+4WMD+OR+4WME+OR+4WMF+OR+4YLU+OR+4YO9+OR+4YOG+OR+4YOI+OR+4YOJ+OR+5C3N+OR+5WKJ+OR+5WKK+OR+5WKL+OR+5WKM+OR+6JIJ+OR+6VGY+OR+6VGZ+OR+6VH0+OR+6VH1+OR+6VH2+OR+6VH3">all</a>]</td>
|
|
<td><a href="/protein/YP_009725301.1">YP_009725301</a> [<a href="/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=YP_009725301.1">domain architecture</a>]</td>
|
|
<td>306</td></tr>
|
|
|
|
<tr>
|
|
<td>Nsp6</td>
|
|
<td><a href="/Structure/cdd/cd21560">cd21560</a></td>
|
|
<td><span title="betacoronavirus non-structural protein 6. Coronaviruses (CoV) redirect and rearrange host cell membranes as part of the viral genome replication and transcription machinery; they induce the formation of double-membrane vesicles in infected cells. CoV non-structural protein 6 (Nsp6), a transmembrane-containing protein, together with Nsp3 and Nsp4, have the ability to induce double-membrane vesicles that are similar to those observed in severe acute respiratory syndrome (SARS) coronavirus-infected cells. By itself, Nsp6 can generate autophagosomes from the endoplasmic reticulum. Autophagosomes are normally generated as a cellular response to starvation to carry cellular organelles and long-lived proteins to lysosomes for degradation. Degradation through autophagy may provide an innate defense against virus infection, or conversely, autophagosomes can promote infection by facilitating the assembly of replicase proteins. In addition to initiating autophagosome formation, Nsp6 also limits autophagosome expansion regardless of how they were induced, i.e. whether they were induced directly by Nsp6, or indirectly by starvation or chemical inhibition of MTOR signaling. This may favor coronavirus infection by compromising the ability of autophagosomes to deliver viral components to lysosomes for degradation.">betaCoV-Nsp6</span></td>
|
|
<td>-</td>
|
|
<td>-</td>
|
|
<td>-</td>
|
|
<td><a href="/protein/YP_009725302.1">YP_009725302</a> [<a href="/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=YP_009725302.1">domain architecture</a>]</td>
|
|
<td>290</td></tr>
|
|
|
|
<tr>
|
|
<td>Nsp7</td>
|
|
<td><a href="/Structure/cdd/cd21827">cd21827</a></td>
|
|
<td><span title="nsp7 replicase. nsp7 (non structural protein 7) has been implicated in viral RNA replication and is predominantly alpha helical in structure. It forms a hexadecameric supercomplex with nsp7 that adopts a hollow cylinder-like structure. The dimensions of the central channel and positive electrostatic properties of the cylinder imply that it confers processivity on RNA-dependent RNA polymerase.">betaCoV_Nsp7</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/7BV2"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=7BV2" width="82%" height="82%" alt="Molecular structure image for 7BV2"/><br>7BV2</a> [<a href="/structure/?term=6M5I+OR+6M71+OR+6WIQ+OR+6WQD+OR+6WTC+OR+6XEZ+OR+6XIP+OR+6XQB+OR+7AAP+OR+7B3B+OR+7B3C+OR+7B3D+OR+7BV1+OR+7BV2+OR+7BZF+OR+7C2K+OR+7CTT+OR+7CXM+OR+7CXN+OR+7CYQ+OR+7D4F+OR+7DCD+OR+7DFG+OR+7DFH+OR+7DOI+OR+7DOK+OR+7DTE+OR+7ED5+OR+7EGQ+OR+7EIZ+OR+7JLT+OR+7KRN+OR+7KRO+OR+7KRP+OR+7L1F+OR+7LG3+OR+7LHQ+OR+7OYG+OR+7OZU+OR+7OZV+OR+7RDX+OR+7RDY+OR+7RDZ+OR+7RE0+OR+7RE1+OR+7RE2+OR+7RE3+OR+7THM+OR+8GWB+OR+8GWE+OR+8GWF+OR+8GWG+OR+8GWI+OR+8GWN+OR+8GWO">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/2AHM"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=2AHM" width="82%" height="82%" alt="Molecular structure image for 2AHM"/><br>2AHM</a> [<a href="/structure/?term=2AHM+OR+1YSY+OR+2KYS+OR+6NUR+OR+5F22">all</a>]</td>
|
|
<td>-</td>
|
|
<td><a href="/protein/YP_009725303.1">YP_009725303</a> [<a href="/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=YP_009725303.1">domain architecture</a>]</td>
|
|
<td>83</td></tr>
|
|
|
|
<tr>
|
|
<td>Nsp8</td>
|
|
<td><a href="/Structure/cdd/cd21831">cd21831</a></td>
|
|
<td><span title="nsp8 replicase. Viral nsp8 (non structural protein 8) forms a hexadecameric supercomplex with nsp7 that adopts a hollow cylinder-like structure. The dimensions of the central channel and positive electrostatic properties of the cylinder imply that it confers processivity on RNA-dependent RNA polymerase.">betaCoV_Nsp8</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/7BV2"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=7BV2" width="82%" height="82%" alt="Molecular structure image for 7BV2"/><br>7BV2</a> [<a href="/structure/?term=6M5I+OR+6M71+OR+6WIQ+OR+6WQD+OR+6WTC+OR+6XEZ+OR+6XIP+OR+6XQB+OR+6YHU+OR+6YYT+OR+7AAP+OR+7B3B+OR+7B3C+OR+7B3D+OR+7BTF+OR+7BV1+OR+7BV2+OR+7BW4+OR+7BZF+OR+7C2K+OR+7CTT+OR+7CXM+OR+7CXN+OR+7CYQ+OR+7D4F+OR+7DCD+OR+7DFG+OR+7DFH+OR+7DOI+OR+7DOK+OR+7DTE+OR+7ED5+OR+7EGQ+OR+7EIZ+OR+7JLT+OR+7KRN+OR+7KRO+OR+7KRP+OR+7L1F+OR+7LG2+OR+7OYG+OR+7OZU+OR+7OZV+OR+7RDX+OR+7RDY+OR+7RDZ+OR+7RE0+OR+7RE1+OR+7RE2+OR+7RE3+OR+7THM+OR+7YWR+OR+8GWB+OR+8GWE+OR+8GWF+OR+8GWG+OR+8GWI+OR+8GWN+OR+8GWO">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/2AHM"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=2AHM" width="82%" height="82%" alt="Molecular structure image for 2AHM"/><br>2AHM</a> [<a href="/structure/?term=2AHM+OR+5F22+OR+6NUR+OR+6NUS">all</a>]</td>
|
|
<td>-</td>
|
|
<td><a href="/protein/YP_009725304.1">YP_009725304</a> [<a href="/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=YP_009725304.1">domain architecture</a>]</td>
|
|
<td>198</td></tr>
|
|
|
|
<tr>
|
|
<td>Nsp9</td>
|
|
<td><a href="/Structure/cdd/cd21898">cd21898</a></td>
|
|
<td><span title="nsp9 replicase. nsp9 is a single-stranded RNA-binding viral protein likely to be involved in RNA synthesis. Its structure comprises of a single beta barrel.">betaCoV_Nsp9</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6W9Q"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6W9Q" width="82%" height="82%" alt="Molecular structure image for 6W9Q"/><br>6W9Q</a> [<a href="/structure/?term=6W4B+OR+6W9Q+OR+6WC1+OR+6WXD+OR+7BWQ+OR+7CYQ+OR+7EGQ+OR+7EIZ+OR+7KRI+OR+7N3K+OR+7THM+OR+8DQU+OR+8GWB+OR+8GWE+OR+8GWF+OR+8GWG+OR+8GWI+OR+8GWN">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/1QZ8"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=1QZ8" width="82%" height="82%" alt="Molecular structure image for 1QZ8"/><br>1QZ8</a> [<a href="/structure/?term=1QZ8+OR+1UW7+OR+3EE7">all</a>]</td>
|
|
<td>-</td>
|
|
<td><a href="/protein/YP_009725305.1">YP_009725305</a> [<a href="/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=YP_009725305.1">domain architecture</a>]</td>
|
|
<td>113</td></tr>
|
|
|
|
<tr>
|
|
<td>Nsp10</td>
|
|
<td><a href="/Structure/cdd/cd21901">cd21901</a></td>
|
|
<td><span title="RNA synthesis protein NSP10. Non-structural protein 10 (NSP10) is involved in RNA synthesis. it is synthesized as a polyprotein whose cleavage generates many non-structural proteins. NSP10 contains two zinc binding motifs and forms two anti-parallel helices which are stacked against an irregular beta sheet. A cluster of basic residues on the protein surface suggests a nucleic acid-binding function.">alpha_betaCoV_Nsp10</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6W4H"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6W4H" width="82%" height="82%" alt="Molecular structure image for 6W4H"/><br>6W4H</a> [<a href="/structure/?term=6W4H+OR+6W61+OR+6W75+OR+6WJT+OR+6WKQ+OR+6WKS+OR+6WQ3+OR+6WRZ+OR+6WVN+OR+6XKM+OR+6YZ1+OR+6ZCT+OR+6ZPE+OR+7BQ7+OR+7C2I+OR+7C2J+OR+7DIY+OR+7EGQ+OR+7EIZ+OR+7JHE+OR+7JIB+OR+7JPE+OR+7JYY+OR+7JZ0+OR+7KOA+OR+7L6R+OR+7L6T+OR+7LW3+OR+7LW4+OR+7MC5+OR+7MC6+OR+7N0B+OR+7N0C+OR+7N0D+OR+7O7Y+OR+7O7Z+OR+7O80+OR+7O81+OR+7ORR+OR+7ORU+OR+7ORV+OR+7ORW+OR+7R1T+OR+7R1U+OR+7ULT+OR+8A23+OR+8BSD+OR+8BZV+OR+8C5M+OR+8F4S+OR+8F4Y+OR+8OT0+OR+8OTR+OR+8OSX+OR+8OV1+OR+8OV2+OR+8OV3+OR+8OV4">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/5C8S"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=5C8S" width="82%" height="82%" alt="Molecular structure image for 5C8S"/><br>5C8S</a> [<a href="/structure/?term=2FYG+OR+2G9T+OR+2GA6+OR+2XYQ+OR+2XYR+OR+2XYV+OR+3R24+OR+5C8S+OR+5C8T+OR+5C8U">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/5YN5"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=5YN5" width="82%" height="82%" alt="Molecular structure image for 5YN5"/><br>5YN5</a> [<a href="/structure/?term=5NFY+OR+5YN5+OR+5YN6+OR+5YN8+OR+5YNB+OR+5YNF+OR+5YNI+OR+5YNJ+OR+5YNM+OR+5YNN+OR+5YNO+OR+5YNP+OR+5YNQ">all</a>]</td>
|
|
<td><a href="/protein/YP_009725306.1">YP_009725306</a> [<a href="/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=YP_009725306.1">domain architecture</a>]</td>
|
|
<td>139</td></tr>
|
|
|
|
<tr>
|
|
<td>Nsp12</td>
|
|
<td><a href="/Structure/cdd/cd21591">cd21591</</td>
|
|
<td><span title="Severe acute respiratory syndrome coronavirus RNA-dependent RNA polymerase, also known as non-structural protein 12, and similar proteins from betacoronaviruses in the B lineage: responsible for replication and transcription of the viral RNA genome. This group contains the RNA-dependent RNA polymerase (RdRp) of Severe acute respiratory syndrome coronavirus (SARS-CoV), SARS-CoV-2 (also known as 2019 novel CoV (2019-nCoV) or COVID-19 virus), and similar proteins from betacoronaviruses in the sarbecovirus subgenera (B lineage). CoVs utilize a multi-subunit replication/transcription machinery. A set of non-structural proteins (Nsps) generated as cleavage products of the ORF1a and ORF1ab viral polyproteins assemble to facilitate viral replication and transcription. A key component, the RNA-dependent RNA polymerase (RdRp, also known as Nsp12), catalyzes the synthesis of viral RNA and thus plays a central role in the replication and transcription cycle of CoV, possibly interacting with its co-factors, Nsp7 and Nsp8. RdRp is therefore considered a primary target for nucleotide analog antiviral inhibitors such as remdesivir, which shows potential for the treatment of SARS-CoV-2 viral infections. The structure of SARS-CoV-2 Nsp12 contains a RdRp domain as well as a large N-terminal extension that adopts a nidovirus RdRp-associated nucleotidyltransferase (NiRAN) architecture. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RpRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.">SARS-CoV-like_RdRp</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/7BV2"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=7BV2" width="82%" height="82%" alt="Molecular structure image for 7BV2"/><br>7BV2</a> [<a href="/structure/?term=66M71+OR+6XEZ+OR+6XQB+OR+6YYT+OR+7AAP+OR+7B3B+OR+7B3C+OR+7B3D+OR+7BTF+OR+7BV1+OR+7BV2+OR+7BZF+OR+7C2K+OR+7CTT+OR+7CXM+OR+7CXN+OR+7CYQ+OR+7D4F+OR+7DFG+OR+7DFH+OR+7DOI+OR+7DOK+OR+7DTE+OR+7ED5+OR+7EGQ+OR+7EIZ+OR+7KRN+OR+7KRO+OR+7KRP+OR+7O7Y+OR+7O7Z+OR+7O80+OR+7O81+OR+7OYG+OR+7OZU+OR+7OZV+OR+7RDX+OR+7RDY+OR+7RDZ+OR+7RE0+OR+7RE1+OR+7RE2+OR+7RE3+OR+7THM+OR+8GWE+OR+8GWF+OR+8GWG+OR+8GWI+OR+8GWN+OR+8GWO">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6NUR"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6NUR" width="82%" height="82%" alt="Molecular structure image for 6NUR"/><br>6NUR</a> [<a href="/structure/?term=6NUR+OR+6NUS">all</a>]</td>
|
|
<td>-</td>
|
|
<td><a href="/protein/YP_009725307.1">YP_009725307</a> [<a href="/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=YP_009725307.1">domain architecture</a>]</td>
|
|
<td>932</td></tr>
|
|
|
|
<tr>
|
|
<td>Nsp13</td>
|
|
<td><a href="/Structure/cdd/cd21401">cd21401</a></td>
|
|
<td><span title="Cys/His rich zinc-binding domain (CH/ZBD) of coronavirus SARS NSP13 helicase and related proteins. Helicases catalyze NTP-dependent unwinding of nucleic acid duplexes into single strands and are classified based on the arrangement of conserved motifs into six superfamilies. This coronavirus family includes Severe Acute Respiratory Syndrome coronavirus (SARS) non-structural protein 13 (SARS-Nsp13) and belongs to helicase superfamily 1 (SF1). The CH/ZBD has 3 zinc-finger (ZnF1-3) motifs. SARS-Nsp13 is a component of the viral RNA synthesis replication and transcription complex (RTC). The SARS-Nsp13 CH/ZBD is indispensable for helicase activity and interacts with SARS-Nsp12. SARS-Nsp12 can enhance the helicase activity of SARS-Nsp13 and can interact with SARS-Nsp13 on the third zinc finger motif of the CH/ZBD. SARS-Nsp13 has an N-terminal CH/ZBD, a stalk domain, a 1B regulatory domain, and SF1 helicase core.">ZBD_cv_Nsp13-like</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6XEZ"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6XEZ" width="82%" height="82%" alt="Molecular structure image for 6XEZ"/><br>6XEZ</a> [<a href="/structure/?term=5RL6+OR+5RL7+OR+5RL8+OR+5RL9+OR+5RLB+OR+5RLC+OR+5RLD+OR+5RLE+OR+5RLF+OR+5RLG+OR+5RLH+OR+5RLI+OR+5RLJ+OR+5RLK+OR+5RLL+OR+5RLM+OR+5RLN+OR+5RLO+OR+5RLP+OR+5RLQ+OR+5RLR+OR+5RLS+OR+5RLT+OR+5RLU+OR+5RLV+OR+5RLW+OR+5RLY+OR+5RLZ+OR+5RM0+OR+5RM1+OR+5RM2+OR+5RM3+OR+5RM4+OR+5RM5+OR+5RM6+OR+5RM7+OR+5RM8+OR+5RM9+OR+5RMA+OR+5RMB+OR+5RMC+OR+5RMD+OR+5RME+OR+5RMF+OR+5RMG+OR+5RMH+OR+5RMI+OR+5RMJ+OR+5RMK+OR+5RML+OR+5RMM+OR+5ROB+OR+6XEZ+OR+6ZSL+OR+7CXM+OR+7CXN+OR+7CYQ+OR+7EGQ+OR+7EIZ+OR+7KRN+OR+7KRO+OR+7NIO+OR+7NN0+OR+7NNG+OR+7RDX+OR+7RDY+OR+7RDZ+OR+7RE0+OR+7RE1+OR+7RE2+OR+7RE3+OR+8GWB+OR+8GWE+OR+8GWF+OR+8GWG+OR+8GWI+OR+8GWN">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6JYT"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6JYT" width="82%" height="82%" alt="Molecular structure image for 6JYT"/><br>6JYT</a></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/5WWP"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=5WWP" width="82%" height="82%" alt="Molecular structure image for 5WWP"/><br>5WWP</a></td>
|
|
<td><a href="/protein/YP_009725308.1">YP_009725308</a> [<a href="/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=YP_009725308.1">domain architecture</a>]</td>
|
|
<td>601</td></tr>
|
|
<tr>
|
|
<td></td>
|
|
<td><a href="/Structure/cdd/cd21689">cd21689</a></td>
|
|
<td><span title="stalk domain of coronavirus Nsp13 helicase and related proteins. This model represents the stalk domain of coronavirus non-structural protein 13 (Nsp13) helicase, found in the Nsp3s of alpha-, beta-, gamma-, and deltacoronaviruses, including Severe Acute Respiratory Syndrome coronavirus (SARS-CoV), SARS-CoV-2 (also called 2019 novel CoV or 2019-nCoV), and Middle East respiratory syndrome coronavirus (MERS-CoV). Helicases are classified based on the arrangement of conserved motifs into six superfamilies; coronavirus helicases in this family belong to superfamily 1 (SF1). Helicases catalyze NTP-dependent unwinding of nucleic acid duplexes into single strands. Nsp13 is a component of the viral RNA synthesis replication and transcription complex (RTC). It consists of an N-terminal ZBD (Cys/His rich zinc-binding domain), a stalk domain, a 1B regulatory domain, and SF1 helicase core. The stalk domain lies between the ZBD domain and the 1B domain; a short loop connects the ZBD to the stalk domain. The stalk domain is comprised of three tightly-interacting alpha-helices connected to the 1B domain, transferring the effect from the ZBD domain onto the helicase core domains. The ZBD and stalk domains are critical for the helicase activity of SARS-CoV Nsp13.">stalk_CoV_Nsp13-like</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6XEZ"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6XEZ" width="82%" height="82%" alt="Molecular structure image for 6XEZ"/><br>6XEZ</a> [<a href="/structure/?term=5RL6+OR+5RL7+OR+5RL8+OR+5RL9+OR+5RLB+OR+5RLC+OR+5RLD+OR+5RLE+OR+5RLF+OR+5RLG+OR+5RLH+OR+5RLI+OR+5RLJ+OR+5RLK+OR+5RLL+OR+5RLM+OR+5RLN+OR+5RLO+OR+5RLP+OR+5RLQ+OR+5RLR+OR+5RLS+OR+5RLT+OR+5RLU+OR+5RLV+OR+5RLW+OR+5RLY+OR+5RLZ+OR+5RM0+OR+5RM1+OR+5RM2+OR+5RM3+OR+5RM4+OR+5RM5+OR+5RM6+OR+5RM7+OR+5RM8+OR+5RM9+OR+5RMA+OR+5RMB+OR+5RMC+OR+5RMD+OR+5RME+OR+5RMF+OR+5RMG+OR+5RMH+OR+5RMI+OR+5RMJ+OR+5RMK+OR+5RML+OR+5RMM+OR+5ROB+OR+6XEZ+OR+6ZSL+OR+7CXM+OR+7CXN+OR+7CYQ+OR+7EGQ+OR+7EIZ+OR+7KRN+OR+7KRO+OR+7NIO+OR+7NN0+OR+7NNG+OR+7RDX+OR+7RDY+OR+7RDZ+OR+7RE0+OR+7RE1+OR+7RE2+OR+7RE3+OR+8GWE+OR+8GWF+OR+8GWG+OR+8GWI+OR+8GWN">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6JYT"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6JYT" width="82%" height="82%" alt="Molecular structure image for 6JYT"/><br>6JYT</a></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/5WWP"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=5WWP" width="82%" height="82%" alt="Molecular structure image for 5WWP"/><br>5WWP</a></td>
|
|
<td></td>
|
|
<td></td></tr>
|
|
<tr>
|
|
<td></td>
|
|
<td><a href="/Structure/cdd/cd21409">cd21409</</td>
|
|
<td><span title="1B domain of coronavirus SARS NSP13 helicase and related proteins. Helicases catalyze NTP-dependent unwinding of nucleic acid duplexes into single strands and are classified based on the arrangement of conserved motifs into six superfamilies. Members of this subfamily belong to helicase superfamily 1 (SF1) and include coronavirus helicases such as Severe Acute Respiratory Syndrome coronavirus (SARS) non-structural protein 13 (SARS-Nsp13). SARS-Nsp13 is a component of the viral RNA synthesis replication and transcription complex (RTC). SARS-Nsp13 is a multidomain protein; its other domains include an N-terminal Cys/His rich zinc-binding domain (CH/ZBD) and a SF1 helicase core. The 1B domain is involved in nucleic acid substrate binding; the 1B domain of the related Equine arteritis virus (EAV) Nsp10 undergoes large conformational change upon substrate binding, and together with the 1A and 2A domains of the helicase core form a channel that accommodates the single stranded nucleic acids.">1B_cv_Nsp13-like</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6XEZ"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6XEZ" width="82%" height="82%" alt="Molecular structure image for 6XEZ"/><br>6XEZ</a> [<a href="/structure/?term=5RL6+OR+5RL7+OR+5RL8+OR+5RL9+OR+5RLB+OR+5RLC+OR+5RLD+OR+5RLE+OR+5RLF+OR+5RLG+OR+5RLH+OR+5RLI+OR+5RLJ+OR+5RLK+OR+5RLL+OR+5RLM+OR+5RLN+OR+5RLO+OR+5RLP+OR+5RLQ+OR+5RLR+OR+5RLS+OR+5RLT+OR+5RLU+OR+5RLV+OR+5RLW+OR+5RLY+OR+5RLZ+OR+5RM0+OR+5RM1+OR+5RM2+OR+5RM3+OR+5RM4+OR+5RM5+OR+5RM6+OR+5RM7+OR+5RM8+OR+5RM9+OR+5RMA+OR+5RMB+OR+5RMC+OR+5RMD+OR+5RME+OR+5RMF+OR+5RMG+OR+5RMH+OR+5RMI+OR+5RMJ+OR+5RMK+OR+5RML+OR+5RMM+OR+5ROB+OR+6XEZ+OR+6ZSL+OR+7CXM+OR+7CXN+OR+7CYQ+OR+7EGQ+OR+7EIZ+OR+7KRN+OR+7KRO+OR+7NIO+OR+7NN0+OR+7NNG+OR+7RDX+OR+7RDY+OR+7RDZ+OR+7RE0+OR+7RE1+OR+7RE2+OR+7RE3+OR+8GWB+OR+8GWE+OR+8GWF+OR+8GWG+OR+8GWI+OR+8GWN">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6JYT"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6JYT" width="82%" height="82%" alt="Molecular structure image for 6JYT"/><br>6JYT</a></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/5WWP"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=5WWP" width="82%" height="82%" alt="Molecular structure image for 5WWP"/><br>5WWP</a></td>
|
|
<td></td>
|
|
<td></td></tr>
|
|
|
|
<tr>
|
|
<td></td>
|
|
<td><a href="/Structure/cdd/cd21722">cd21722</a></td>
|
|
<td><span title="helicase domain of betacoronavirus non-structural protein 13. This model represents the helicase domain of non-structural protein 13 (Nsp13) from betacoronavirus, including pathogenic human viruses such as Severe acute respiratory syndrome coronavirus (SARS-CoV), SARS-CoV2 (also called 2019 novel CoV or 2019-nCoV), and Middle East respiratory syndrome-related (MERS) CoV. Helicases catalyze NTP-dependent unwinding of nucleic acid duplexes into single strands and are classified based on the arrangement of conserved motifs into six superfamilies. CoV Nsp13 is a member of the helicase superfamily 1 (SF1); SF1 and SF2 helicases do not form toroidal structures, while SF3-6 helicases do. Nsp13 is a component of the viral RNA synthesis replication and transcription complex (RTC). It is a multidomain protein containing a Cys/His rich zinc-binding domain (CH/ZBD), a stalk domain, a 1B domain involved in nucleic acid substrate binding, and a SF1 helicase core.">betaCoV_Nsp13-helicase</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6XEZ"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6XEZ" width="82%" height="82%" alt="Molecular structure image for 6XEZ"/><br>6XEZ</a> [<a href="/structure/?term=5RL6+OR+5RL7+OR+5RL8+OR+5RL9+OR+5RLB+OR+5RLC+OR+5RLD+OR+5RLE+OR+5RLF+OR+5RLG+OR+5RLH+OR+5RLI+OR+5RLJ+OR+5RLK+OR+5RLL+OR+5RLM+OR+5RLN+OR+5RLO+OR+5RLP+OR+5RLQ+OR+5RLR+OR+5RLS+OR+5RLT+OR+5RLU+OR+5RLV+OR+5RLW+OR+5RLY+OR+5RLZ+OR+5RM0+OR+5RM1+OR+5RM2+OR+5RM3+OR+5RM4+OR+5RM5+OR+5RM6+OR+5RM7+OR+5RM8+OR+5RM9+OR+5RMA+OR+5RMB+OR+5RMC+OR+5RMD+OR+5RME+OR+5RMF+OR+5RMG+OR+5RMH+OR+5RMI+OR+5RMJ+OR+5RMK+OR+5RML+OR+5RMM+OR+5ROB+OR+6XEZ+OR+6ZSL+OR+7CXM+OR+7CXN+OR+7CYQ+OR+7EGQ+OR+7EIZ+OR+7KRN+OR+7KRO+OR+7NIO+OR+7NN0+OR+7NNG+OR+7RDX+OR+7RDY+OR+7RDZ+OR+7RE0+OR+7RE1+OR+7RE2+OR+7RE3+OR+8GWB+OR+8GWE+OR+8GWF+OR+8GWG+OR+8GWI+OR+8GWN+OR+8GWO">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6JYT"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6JYT" width="82%" height="82%" alt="Molecular structure image for 6JYT"/><br>6JYT</a></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/5WWP"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=5WWP" width="82%" height="82%" alt="Molecular structure image for 5WWP"/><br>5WWP</a></td>
|
|
<td></td>
|
|
<td></td></tr>
|
|
|
|
<tr>
|
|
<td></td>
|
|
<td><a href="/Structure/cdd/cd17934">cd17934</a></td>
|
|
<td><span title="DEXXQ-box helicase domain of Upf1-like helicase. The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They belong to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.">DEXXQc_Upf1-like</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6XEZ"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6XEZ" width="82%" height="82%" alt="Molecular structure image for 6XEZ"/><br>6XEZ</a> [<a href="/structure/?term=5RL6+OR+5RL7+OR+5RL8+OR+5RL9+OR+5RLB+OR+5RLC+OR+5RLD+OR+5RLE+OR+5RLF+OR+5RLG+OR+5RLH+OR+5RLI+OR+5RLJ+OR+5RLK+OR+5RLL+OR+5RLM+OR+5RLN+OR+5RLO+OR+5RLP+OR+5RLQ+OR+5RLR+OR+5RLS+OR+5RLT+OR+5RLU+OR+5RLV+OR+5RLW+OR+5RLY+OR+5RLZ+OR+5RM0+OR+5RM1+OR+5RM2+OR+5RM3+OR+5RM4+OR+5RM5+OR+5RM6+OR+5RM7+OR+5RM8+OR+5RM9+OR+5RMA+OR+5RMB+OR+5RMC+OR+5RMD+OR+5RME+OR+5RMF+OR+5RMG+OR+5RMH+OR+5RMI+OR+5RMJ+OR+5RMK+OR+5RML+OR+5RMM+OR+6XEZ+OR+6ZSL+OR+7CXM+OR+7CXN+OR+7CYQ+OR+8GWB">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="https://Structure/pdb/6JYT"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6JYT" width="82%" height="82%" alt="Molecular structure image for 6JYT"/><br>6JYT</a></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/5WWP"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=5WWP" width="82%" height="82%" alt="Molecular structure image for 5WWP"/><br>5WWP</a> [<a href="/structure/?term=5WWP+OR+3UPU+OR+6JIM">all</a>]</td>
|
|
<td></td><td></td></tr><tr><td></td>
|
|
<td><a href="/Structure/cdd/cd18808">cd18808</a></td>
|
|
<td><span title="C-terminal helicase domain of Upf1-like family helicases. The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.">SF1_C_Upf1</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6XEZ"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6XEZ" width="82%" height="82%" alt="Molecular structure image for 6XEZ"/><br>6XEZ</a> [<a href="/structure/?term=6XEZ+OR+6ZSL">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6JYT"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6JYT" width="82%" height="82%" alt="Molecular structure image for 6JYT"/><br>6JYT</a></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/5WWP"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=5WWP" width="82%" height="82%" alt="Molecular structure image for 5WWP"/><br>5WWP</a></td>
|
|
<td></td><td></td></tr>
|
|
|
|
<tr>
|
|
<td>Nsp14</td>
|
|
<td><a href="/Structure/cdd/cd21659">cd21659</a></td>
|
|
<td><span title="nonstructural protein 14 of betacoronavirus. Nonstructural protein 14 (Nsp14) of coronavirus (CoV) plays an important role in viral replication and transcription. It consists of 2 domains with different enzymatic activities: an N-terminal exoribonuclease (ExoN) domain and a C-terminal cap (guanine-N7) methyltransferase (N7-MTase) domain. ExoN is important for proofreading and therefore, the prevention of lethal mutations. The association of Nsp14 with Nsp10 stimulates its ExoN activity; the complex hydrolyzes double-stranded RNA in a 3' to 5' direction as well as a single mismatched nucleotide at the 3'-end mimicking an erroneous replication product. The Nsp10/Nsp14 complex may function in a replicative mismatch repair mechanism. N7-MTase functions in mRNA capping. Nsp14 can methylate GTP, dGTP as well as cap analogs GpppG, GpppA and m7GpppG. The accumulation of m7GTP or Nsp14 has been found to interfere with protein translation of cellular mRNAs.">betaCoV_Nsp14</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/7EGQ"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=7EGQ" width="82%" height="82%" alt="Molecular structure image for 7EGQ"/><br>7EGQ</a> [<a href="/structure/?term=5SKW+OR+5SKX+OR+5SKY+OR+5SKZ+OR+5SL0+OR+5SL1+OR+5SL2+OR+5SL3+OR+5SL4+OR+5SL5+OR+5SL6+OR+5SL7+OR+5SL8+OR+5SL9+OR+5SLA+OR+5SLB+OR+5SLC+OR+5SLD+OR+5SLE+OR+5SLF+OR+5SLG+OR+5SLH+OR+5SLI+OR+5SLJ+OR+5SLK+OR+5SLL+OR+5SLM+OR+5SLN+OR+5SLO+OR+5SLP+OR+5SLQ+OR+5SLR+OR+5SLS+OR+5SLT+OR+5SLU+OR+5SLV+OR+5SLW+OR+5SLX+OR+5SLY+OR+5SLZ+OR+5SM0+OR+5SM1+OR+5SM2+OR+5SM3+OR+5SM4+OR+5SM5+OR+5SM6+OR+5SM7+OR+5SM8+OR+5SM9+OR+5SMA+OR+5SMB+OR+5SMC+OR+5SMD+OR+5SME+OR+5SMF+OR+5SMG+OR+5SMH+OR+5SMI+OR+5SMK+OR+7EGQ+OR+7QGI+OR+7QIF+OR+7R2V+OR+7TW7+OR+7TW8+OR+7TW9+OR+8BWU+OR+8CMG+OR+8FRJ+OR+8FRK">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/5C8T"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=5C8T" width="82%" height="82%" alt="Molecular structure image for 5C8T"/><br>5C8T</a> [<a href="/structure/?term=5C8T+OR+5C8S+OR+5C8U+OR+5NFY">all</a>]</td>
|
|
<td>-</td>
|
|
<td><a href="/protein/YP_009725309.1">YP_009725309</a> [<a href="/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=YP_009725309.1">domain architecture</a>]</td>
|
|
<td>527</td></tr>
|
|
|
|
<tr>
|
|
<td>Nsp15</td>
|
|
<td><a href="/Structure/cdd/cd21171">cd21171</a></td>
|
|
<td><span title="N-terminal domain of alpha- and beta-coronavirus Nonstructural protein 15 (Nsp15), and related proteins. Coronavirus Nsp15 is a nidovirus endoribonuclease (NendoU). NendoUs are uridylate-specific endoribonucleases, which release a cleavage product containing a 2',3'-cyclic phosphate at the 3' terminal end. NendoUs include coronavirus Nsp15 and arterivirus Nsp11, both of which may participate in the viral replication process and in the evasion of the host immune system. This small NTD structure, present in coronavirus Nsp15, is missing in Nsp11. Coronavirus Nsp15 has an N-terminal domain, a middle (M) domain, and a C-terminal catalytic (NendoU) domain. Nsp15 from Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), human Coronavirus 229E (HCoV229E), and Murine Hepatitis Virus (MHV) form a functional hexamer. Residues in this N-terminal domain are important for hexamer (dimer of trimers) formation.">NTD_alpha_beta_cv_Nsp15-like</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6WLC"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6WLC" width="82%" height="82%" alt="Molecular structure image for 6WLC"/><br>6WLC</a> [<a href="/structure/?term=5S6X+OR+5S6Y+OR+5S6Z+OR+5S70+OR+5S71+OR+5S72+OR+5SA4+OR+5SA5+OR+5SA6+OR+5SA7+OR+5SA8+OR+5SA9+OR+5SAA+OR+5SAB+OR+5SAC+OR+5SAD+OR+5SAE+OR+5SAF+OR+5SAG+OR+5SAH+OR+5SAI+OR+5SBF+OR+6VWW+OR+6W01+OR+6WLC+OR+6WXC+OR+6X1B+OR+6X4I+OR+6XDH+OR+7K0R+OR+7K1L+OR+7K1O+OR+7K9P+OR+7KEG+OR+7KEH+OR+7KF4+OR+7ME0+OR+7N06+OR+7N33+OR+7N7R+OR+7N7U+OR+7N7W+OR+7N7Y+OR+7N83+OR+7RB0+OR+7RB2+OR+7TJ2+OR+7TQV+OR+8D34+OR+8U2X">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/2H85"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=2H85" width="82%" height="82%" alt="Molecular structure image for 2H85"/><br>2H85</a> [<a href="/structure/?term=2RHB+OR+2H85+OR+2OZK">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/5YVD"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=5YVD" width="82%" height="82%" alt="Molecular structure image for 5YVD"/><br>5YVD</a> [<a href="/structure/?term=5YVD+OR+4RS4+OR+4S1T+OR+2GTH+OR+2GTI">all</a>]</td>
|
|
<td><a href="/protein/YP_009725310.1">YP_009725310</a> [<a href="/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=YP_009725310.1">domain architecture</a>]</td>
|
|
<td>346</td></tr>
|
|
|
|
<tr>
|
|
<td></td>
|
|
<td><a href="/Structure/cdd/cd21167">cd21167</a></td>
|
|
<td><span title="middle domain of alpha- and beta-coronavirus Nonstructural protein 15 (Nsp15), and related proteins. Nidovirus endoribonucleases (NendoUs) are uridylate-specific endoribonucleases, which release a cleavage product containing a 2',3'-cyclic phosphate at the 3' terminal end. NendoUs include Nsp15 from coronaviruses and Nsp11 from arteriviruses, both of which may participate in the viral replication process and in the evasion of the host immune system. Coronavirus Nsp15 NendoUs have an N-terminal domain, a middle (M) domain and a C-terminal catalytic (NendoU) domain. Coronavirus Nsp15 from Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), human Coronavirus 229E (HCoV229E), and Murine Hepatitis Virus (MHV) form a functional hexamer. This middle domain harbors residues involved in hexamer formation and in trimer stability. Oligomerization of Porcine DeltaCoronavirus (PDCoV) Nsp15 differs from that of the other coronaviruses; it has been shown to exist as a dimer and a monomer in solution.">M_alpha_beta_cv_Nsp15-like</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6WLC"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6WLC" width="82%" height="82%" alt="Molecular structure image for 6WLC"/><br>6WLC</a> [<a href="/structure/?term=5S6X+OR+5S6Y+OR+5S6Z+OR+5S70+OR+5S71+OR+5S72+OR+5SA4+OR+5SA5+OR+5SA6+OR+5SA7+OR+5SA8+OR+5SA9+OR+5SAA+OR+5SAB+OR+5SAC+OR+5SAD+OR+5SAE+OR+5SAF+OR+5SAG+OR+5SAH+OR+5SAI+OR+5SBF+OR+6VWW+OR+6W01+OR+6WLC+OR+6WXC+OR+6X1B+OR+6X4I+OR+6XDH+OR+7K0R+OR+7K1L+OR+7K1O+OR+7K9P+OR+7KEG+OR+7KEH+OR+7KF4+OR+7ME0+OR+7N06+OR+7N33+OR+7N7R+OR+7N7U+OR+7N7W+OR+7N7Y+OR+7N83+OR+7RB0+OR+7RB2+OR+7TJ2+OR+7TQV+OR+8D34+OR+8U2X">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/2H85"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=2H85" width="82%" height="82%" alt="Molecular structure image for 2H85"/><br>2H85</a> [<a href="/structure/?term=2RHB+OR+2H85+OR+2OZK">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/5YVD"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=5YVD" width="82%" height="82%" alt="Molecular structure image for 5YVD"/><br>5YVD</a> [<a href="/structure/?term=5YVD+OR+4RS4+OR+4S1T+OR+2GTH+OR+2GTI">all</a>]</td>
|
|
<td></td>
|
|
<td></td></tr>
|
|
|
|
<tr><td></td>
|
|
<td><a href="/Structure/cdd/cd21161">cd21161</a></td>
|
|
<td><span title="Nidoviral uridylate-specific endoribonuclease (NendoU) domain of coronavirus Nonstructural Protein 15 (Nsp15) and related proteins. Nidovirus endoribonucleases (NendoUs) are uridylate-specific endoribonucleases, which release a cleavage product containing a 2',3'-cyclic phosphate at the 3' terminal end. NendoUs include Nsp15 from coronaviruses and Nsp11 from arteriviruses, both of which may participate in the viral replication process and in the evasion of the host immune system. Except for turkey coronavirus (TCoV) Nsp15, Mn2+ is generally essential for the catalytic activity of coronavirus Nsp15. Coronavirus Nsp15 from Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), human Coronavirus 229E (HCoV229E), and murine hepatitis virus (MHV) form a functional hexamer while Porcine DeltaCoronavirus (PDCoV) Nsp15 has been shown to exist as a dimer and a monomer in solution. NendoUs are distantly related to Xenopus laevis Mn(2+)-dependent uridylate-specific endoribonuclease (XendoU) which is involved in the processing of intron-encoded box C/D U16 small, nucleolar RNA.">NendoU_cv_Nsp15-like</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6WLC"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6WLC" width="82%" height="82%" alt="Molecular structure image for 6WLC"/><br>6WLC</a> [<a href="/structure/?term=5S6X+OR+5S6Y+OR+5S6Z+OR+5S70+OR+5S71+OR+5S72+OR+5SA4+OR+5SA5+OR+5SA6+OR+5SA7+OR+5SA8+OR+5SA9+OR+5SAA+OR+5SAB+OR+5SAC+OR+5SAD+OR+5SAE+OR+5SAF+OR+5SAG+OR+5SAH+OR+5SAI+OR+5SBF+OR+6VWW+OR+6W01+OR+6WLC+OR+6WXC+OR+6X1B+OR+6X4I+OR+6XDH+OR+7K0R+OR+7K1L+OR+7K1O+OR+7K9P+OR+7KEG+OR+7KEH+OR+7KF4+OR+7ME0+OR+7N06+OR+7N33+OR+7N7R+OR+7N7U+OR+7N7W+OR+7N7Y+OR+7N83+OR+7RB0+OR+7RB2+OR+7TJ2+OR+7TQV+OR+8D34+OR+8U2X">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/2H85"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=2H85" width="82%" height="82%" alt="Molecular structure image for 2H85"/><br>2H85</a> [<a href="/structure/?term=2RHB+OR+2H85+OR+2OZK">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/5YVD"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=5YVD" width="82%" height="82%" alt="Molecular structure image for 5YVD"/><br>5YVD</a> [<a href="/structure/?term=5YVD+OR+4RS4+OR+4S1T+OR+2GTH+OR+2GTI">all</a>]</td>
|
|
<td></td>
|
|
<td></td></tr>
|
|
|
|
<tr>
|
|
<td>Nsp16</td>
|
|
<td><a href="/Structure/cdd/cd20762">cd20762</a></td>
|
|
<td><span title="Cap-0 specific (nucleoside-2'-O-)-methyltransferase of nidovirales. Cap-0 specific (nucleoside-2'-O-)-methyltransferase (2'OMTase) catalyzes the methylation of Cap-0 (m7GpppNp) at the 2'-hydroxyl of the ribose of the first nucleotide, using S-adenosyl-L-methionine (AdoMet) as the methyl donor. This reaction is the fourth and last step in mRNA capping, the creation of the stabilizing five-prime cap (5' cap) on mRNA. Nidovirales, a family of ss(+)RNA viruses, cap their mRNAs. For one member, Coronavirus, the 2'OMTase activity is located in the nonstructural protein 16 (NSP16). For others, the 2'OMTase activity may be located in replicase polyprotein 1ab.">capping_2-OMTase_Nidovirales</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6W4H"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6W4H" width="82%" height="82%" alt="Molecular structure image for 6W4H"/><br>6W4H</a> [<a href="/structure/?term=6W4H+OR+6W61+OR+6W75+OR+6WJT+OR+6WKQ+OR+6WQ3+OR+6WRZ+OR+6WVN+OR+6YZ1+OR+7BQ7+OR+7C2I+OR+7C2J+OR+7JYY+OR+7JZ0+OR+7KOA+OR+7L6R+OR+7L6T+OR+7LW3+OR+7LW4+OR+7R1T+OR+7R1U+OR+8A23+OR+8BSD+OR+8BZV+OR+8C5M+OR+8F4S+OR+8F4Y+OR+8OT0+OR+8OTO+OR+8OSX+OR+8OV1+OR+8OV2+OR+8OV3+OR+8OV4">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/2XYQ"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=2XYQ" width="82%" height="82%" alt="Molecular structure image for 2XYQ"/><br>2XYQ</a> [<a href="/structure/?term=2XYQ+OR+3R24+OR+2XYR+OR+2XYV+OR+8OTR">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/5YN5"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=5YN5" width="82%" height="82%" alt="Molecular structure image for 5YN5"/><br>5YN5</a> [<a href="/structure/?term=5YN5+OR+5YN6+OR+5YN8+OR+5YNB+OR+5YNF+OR+5YNI+OR+5YNJ+OR+5YNM+OR+5YNN+OR+5YNO+OR+5YNP+OR+5YNQ">all</a>]</td>
|
|
<td><a href="/protein/YP_009725311.1">YP_009725311</a> [<a href="/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=YP_009725311.1">domain architecture</a>]</td>
|
|
<td>298</td></tr>
|
|
|
|
<tr>
|
|
<td colspan = 8><b>Accessory proteins:</b></td>
|
|
</tr><tr><td>ORF3a</td>
|
|
<td><a href="/Structure/cdd/cd21648">cd21648</a></td>
|
|
<td><span title="accessory protein ORF3a of severe acute respiratory syndrome-associated coronavirus and similar proteins from related betacoronavirus. This model represents the accessory protein ORF3a of Severe acute respiratory syndrome-associated coronavirus (SARS-CoV), SARS-COV-2 (also called 2019 novel coronavirus or 2019-nCoV), and related betacoronaviruses in the Sarbecovirus subgenus (B lineage). There are five essential genes in CoVs that result in the following gene products: Spike (S) protein, Membrane (M) glycoprotein, Nucleocapsid (N), Envelope (E) protein, and replicase/protease polyproteins (ORF1ab); all are required to produce a structurally complete viral particle. In addition, CoV genomes also contain ORFs coding for accessory proteins that are specific for certain CoV lineages or for a particular CoV. In general, CoV accessory proteins are considered to be dispensable for viral replication; however, several accessory proteins have been shown to exhibit functions in virus-host interactions during CoV infection. SARS-CoV mRNA 3 encodes the distinct proteins ORF3a and ORF3b, which are translated in different reading frames. Accessory protein ORF3a, also called protein 3a and protein X1, is the largest ORF protein in SARS-CoV. It is also called accessory protein 3 or protein 3 in some bat coronaviruses. SARS-CoV ORF3a promotes membrane rearrangement and cell death; it induces vesicle formation and is necessary for SARS-CoV-induced Golgi fragmentation. It has also been found to activate NF-kappaB and the NLRP3 inflammasome by promoting TNF receptor-associated factor 3 (TRAF3)-dependent ubiquitination of p105 and ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain). The cytoplasmic domain of SARS-CoV ORF3a, composed of amino acids at the C-terminal region, has sequence similarity to a calcium pump present in Plasmodium falciparum and has been shown to bind calcium in vitro.">SARS-CoV-like_ORF3a</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6XDC"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6XDC" width="82%" height="82%" alt="Molecular structure image for 6XDC"/><br>6XDC</a> [<a href="/structure/?term=6XDC+OR+7KJR+OR+8EQJ+OR+8EQT+OR+8EQU">all</a>]</td>
|
|
<td>-</td>
|
|
<td>-</td>
|
|
<td><a href="/protein/YP_009724391.1">YP_009724391</a> [<a href="/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=YP_009724391.1">domain architecture</a>]</td><td>275</td></tr>
|
|
|
|
<tr>
|
|
<td>ORF6</td>
|
|
<td><a href="/Structure/cdd/pfam12133">pfam12133</a></td>
|
|
<td><span title="Open reading frame 6 from SARS coronavirus. This family is found in Coronaviruses. Proteins in this family are typically between 42 to 63 amino acids in length.">Sars6</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/7VPH"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=7VPH" width="82%" height="82%" alt="Molecular structure image for 7VPH"/><br>7VPH</a> [<a href="/structure/?term=7VPH+OR+7F60">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/7VPG"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=7VPG" width="82%" height="82%" alt="Molecular structure image for 7VPG"/><br>7VPG</a></td>
|
|
<td>-</td>
|
|
<td><a href="/protein/YP_009724394.1">YP_0097243</a> [<a href="/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=YP_009724394.1">domain architecture</a>]</td><td>61</td></tr>
|
|
|
|
<tr>
|
|
<td>ORF7a</td>
|
|
<td><a href="/Structure/cdd/cd21663">cd21663</a></td>
|
|
<td><span title="Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) structural accessory protein ORF7a and similar proteins from related betacoronaviruses in the subgenera Sarbecovirus (B lineage). This family contains the structural accessory protein ORF7a, also called NS7a, of Severe Acute Respiratory Syndrome Coronaviruses (SARS-CoVs) from betacoronavirus subgenera Sarbecovirus (lineage B), including SARS-CoV-2, also known as 2019-nCoV, and a bat coronavirus (BatCoV RaTG13), which was previously detected in Rhinolophus affinis from China's Yunnan province, as well as SARS-related virus from Rhinolophus bats in Europe and Kenya. ORF7a/NS7a from betacoronavirus in the subgenera Sarbecovirus (lineage B) are not related to NS7a proteins from other coronavirus lineages. There are five essential genes in CoVs that result in the following gene products: Spike (S) protein, Membrane (M) glycoprotein, Nucleocapsid (N), Envelope (E) protein, and the ORF1ab (a large polyprotein known as replicase/protease); all required to produce a structurally complete viral particle. In addition, SARS-CoV contains a number of open reading frames that code for a total of eight accessory proteins, namely ORFs 3a, 3b, 6, 7a, 7b, 8a, 8b, and 9b. These ORFs are specific for SARS-CoV and do not show significant homology to accessory proteins of other coronaviruses. Structurally, ORF7a possesses a distinctive immunoglobulin (Ig)-like domain which is related to extracellular metazoan Ig domains that are involved in adhesion, such as ICAM; it also contains a 15-amino acid signal peptide sequence at its N terminus, an 81-amino acid luminal domain, a 21-amino acid transmembrane domain, and a short C-terminal tail. Co-expression of SARS-CoV ORF7a with S, M, N and E proteins resulted in production of virus-like particles (VLPs) carrying ORF7a protein, indicating that ORF7a is a viral structural protein. Expression studies of ORF7a have shown that biological functions include induction of apoptosis through a caspase-dependent pathway, activation of the p38 mitogen-activated protein kinase signaling pathway, inhibition of host protein translation, and suppression of cell growth progression. These results collectively suggested that ORF7a protein may be involved in virus-host interactions.">ORF7a_SARS-CoV-like</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6W37"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6W37" width="82%" height="82%" alt="Molecular structure image for 6W37"/><br>6W37</a> [<a href="/structure/?term=6W37+OR+7CI3">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/1XAK"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=1XAK" width="82%" height="82%" alt="Molecular structure image for 1XAK"/><br>1XAK</a> [<a href="/structure/?term=1XAK+OR+1YO4">all</a>]</td>
|
|
<td>-</td>
|
|
<td><a href="/protein/YP_009724395.1">YP_009724395</a> [<a href="/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=YP_009724395.1">domain architecture</a>]</td><td>121</td></tr>
|
|
|
|
<tr>
|
|
<td>ORF7b </td>
|
|
<td><a href="/Structure/cdd/cd21623">cd21623</a></td>
|
|
<td><span title="Structural accessory protein ORF7b of Severe Acute Respiratory Syndrome coronavirus 2 and similar proteins. This group contains the ORF7b, also called NS7b, of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), also known as 2019-nCoV, and a bat coronavirus (BatCoV RaTG13), which was previously detected in Rhinolophus affinis from China's Yunnan province and showed high sequence identity to SARS-CoV-2. ORF7b/NS7b from betacoronavirus in the B lineage are not related to NS7b proteins from other betacoronavirus lineages. There are five essential genes in CoVs that result in the following gene products: Spike (S) protein, Membrane (M) glycoprotein, Nucleocapsid (N), Envelope (E) protein, and the ORF1ab (a large polyprotein known as replicase/protease); all required to produce a structurally complete viral particle. In addition, SARS coronavirus contains a number of open reading frames that code for a total of eight accessory proteins, namely ORFs 3a, 3b, 6, 7a, 7b, 8a, 8b, and 9b. These ORFs are specific for SARS-CoV and do not show significant homology to accessory proteins of other coronaviruses. The SARS-CoV ORF7b protein is a highly hydrophobic 43 amino acid protein which is homologous to an accessory but structural component of SARS-CoV virion. While ORF7b is packaged into virions, it is not required for the virus budding process, as gene 7 deletion viruses replicate efficiently in vitro and in vivo. Moreover, ORF7b possesses a transmembrane helical domain (TMD), between 9-29 amino acid residues, is necessary for its Golgi complex localization, as replacing it with the TMD from the human endoprotease furin results in aberrant localization.">ORF7b_SARS-CoV-2</span></td>
|
|
<td>-</td>
|
|
<td>-</td>
|
|
<td>-</td>
|
|
<td><a href="/protein/YP_009725318.1">YP_009725318</a> [<a href="/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=YP_009725318.1">domain architecture</a>]</td>
|
|
<td>43</td></tr>
|
|
|
|
<tr>
|
|
<td>ORF8</td>
|
|
<td><a href="/Structure/cdd/cd21641">cd21641</a></td>
|
|
<td><span title="SARS-CoV-2 ORF8 immunoglobulin (Ig) domain protein and related proteins. This subfamily includes the ORF8 immunoglobulin (Ig) domain protein of Severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2, also known as a 2019 novel coronavirus, 2019-nCoV) and related Sarbecovirus ORF8 proteins. SARS-CoV-2 causes the disease called "coronavirus disease 2019" (COVID-19). SARS-CoV-2 ORF8 (also known as ns8 and accessory protein 8) is a fast-evolving protein in SARS-related CoVs, and a potential pathogenicity factor which evolves rapidly to counter the immune response and facilitate the transmission between hosts (DOI:10.1101/2020.03.04.977736). It belongs to a family which includes Sarbecovirus ORF8 proteins classified as type II, such as bat coronavirus Rf1 ORF8, and those classified as type III, such as Bat SARS coronavirus HKU3-1 ORF8.">ORF8-Ig_SARS-CoV-2-like</span></td> <td style="white-space:nowrap;"><a href="/Structure/pdb/7JX6"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=7JX6" width="82%" height="82%" alt="Molecular structure image for 7JX6"/><br>7JX6</a> [<a href="/structure/?term=7JX6+OR+7JTL+OR+7MX9">all</a>]</td>
|
|
<td>-</td>
|
|
<td>-</td>
|
|
<td><a href="/protein/YP_009724396.1">YP_009724396</a> [<a href="/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=YP_009724396.1">domain architecture</a>]</td>
|
|
<td>121</td></tr>
|
|
|
|
<tr>
|
|
<td>ORF10</td>
|
|
<td><a href="/Structure/cdd/cd21597">cd21597</a></td>
|
|
<td><span title="Severe acute respiratory syndrome coronavirus 2 Orf10. This model represents the Orf10 protein of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as 2019 novel coronavirus (2019-nCoV). SARS-CoV-2 causes the disease called "coronavirus disease 2019" (COVID-19). Orf10 appears to have no homologous proteins in SARS-CoV and other coronaviruses. It has been suggested that the genome sequence currently annotated as orf10 may not have a protein coding function in SARS-CoV-2, and instead may act, itself or as a precursor of other RNAs, in the regulation of gene expression, replication, or modulating cellular antiviral pathways (DOI:10.1101/2020.03.05.976167).">SARS-CoV-2_Orf10</span></td>
|
|
<td>-</td>
|
|
<td>-</td>
|
|
<td>-</td>
|
|
<td><a href="/protein/YP_009725255.1">YP_009725255</a> [<a href="/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=YP_009725255.1">domain architecture</a>]</td><td>38</td></tr>
|
|
|
|
<tr>
|
|
<td colspan = 8><b>Structural proteins:</b></td></tr>
|
|
<tr><td>(S)pike</td>
|
|
<td><a href="/Structure/cdd/cd21624">cd21624</a></td>
|
|
<td><span title="N-terminal domain of the S1 subunit of the Spike (S) protein from Severe acute respiratory syndrome coronavirus and related betacoronaviruses in the B lineage. This subfamily contains the N-terminal domain (NTD) of the S1 subunit of the Spike (S) proteins from betacoronaviruses in the sarbecovirus subgenera (B lineage), including the highly pathogenic human coronavirus (CoV), Severe acute respiratory syndrome (SARS) CoV, and SARS-CoV-2, also known as a 2019 novel coronavirus (2019-nCoV) or COVID-19 virus. The CoV S protein is an envelope glycoprotein that plays the most important role in viral attachment, fusion, and entry into host cells, and serves as a major target for the development of neutralizing antibodies, inhibitors of viral entry, and vaccines. It is synthesized as a precursor protein that is cleaved into an N-terminal S1 subunit (~700 amino acids) and a C-terminal S2 subunit (~600 amino acids) that mediates attachment and membrane fusion, respectively. Three S1/S2 heterodimers assemble to form a trimer spike protruding from the viral envelope. The S1 subunit contains a receptor-binding domain (RBD), while the S2 subunit contains a hydrophobic fusion peptide and two heptad repeat regions. S1 contains two structurally independent domains, the N-terminal domain (NTD) and the C-terminal domain (C-domain). Depending on the virus, either the NTD or the C-domain can serve as the receptor-binding domain (RBD). Most CoVs, including SARS-CoV-2 and SARS-CoV, use the C-domain to bind their receptors. The S1 NTD contributes to the Spike trimer interface.">SARS-CoV-like_Spike_S1_NTD</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6VXX"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6VXX" width="82%" height="82%" alt="Molecular structure image for 6VXX"/><br>6VXX</a> [<a href="/structure/?term=6VSB+OR+6VXX+OR+6VYB+OR+6WPS+OR+6WPT+OR+6X29+OR+6X2A+OR+6X2B+OR+6X2C+OR+6X6P+OR+6X79+OR+6XCM+OR+6XCN+OR+6XEY+OR+6XF5+OR+6XF6+OR+6XKL+OR+6XLU+OR+6XM0+OR+6XM3+OR+6XM4+OR+6XM5+OR+6XR8+OR+6XRA+OR+6XS6+OR+6Z43+OR+6Z97+OR+6ZB4+OR+6ZB5+OR+6ZDH+OR+6ZGE+OR+6ZGG+OR+6ZGH+OR+6ZGI+OR+6ZHD+OR+6ZOW+OR+6ZOX+OR+6ZOY+OR+6ZOZ+OR+6ZP0+OR+6ZP1+OR+6ZP2+OR+6ZP5+OR+6ZP7+OR+6ZWV+OR+6ZXN+OR+7A25+OR+7A29+OR+7A4N+OR+7A5R+OR+7A5S+OR+7A91+OR+7A92+OR+7A93+OR+7A94+OR+7A95+OR+7A96+OR+7A97+OR+7A98+OR+7AD1+OR+7AKD+OR+7B14+OR+7B18+OR+7B62+OR+7BNM+OR+7BNN+OR+7BNO+OR+7BYR+OR+7C2L+OR+7CAB+OR+7CAC+OR+7CAI+OR+7CAK+OR+7CHH+OR+7CN9+OR+7CT5+OR+7CWL+OR+7CWM+OR+7CWN+OR+7CWO+OR+7CWS+OR+7CWT+OR+7CWU+OR+7CYP+OR+7CZP+OR+7CZQ+OR+7CZR+OR+7CZS+OR+7CZT+OR+7CZU+OR+7CZV+OR+7CZW+OR+7CZX+OR+7CZY+OR+7CZZ+OR+7D00+OR+7D03+OR+7D0B+OR+7D0C+OR+7D0D+OR+7D4G+OR+7DCC+OR+7DCX+OR+7DD2+OR+7DD8+OR+7DDD+OR+7DDN+OR+7DF3+OR+7DF4+OR+7DK3+OR+7DK4+OR+7DK5+OR+7DK6+OR+7DK7+OR+7DWX+OR+7DWY+OR+7DWZ+OR+7DX0+OR+7DX1+OR+7DX2+OR+7DX3+OR+7DX5+OR+7DX6+OR+7DX7+OR+7DX8+OR+7DX9+OR+7DZW+OR+7DZX+OR+7DZY+OR+7E3K+OR+7E3L+OR+7E5R+OR+7E5S+OR+7E7B+OR+7E7D+OR+7E7X+OR+7E8C+OR+7E9N+OR+7E9O+OR+7E9P+OR+7E9Q+OR+7EAZ+OR+7EB0+OR+7EB3+OR+7EB4+OR+7EB5+OR+7EDF+OR+7EDG+OR+7EDH+OR+7EDI+OR+7EDJ+OR+7EH5+OR+7EJ4+OR+7EJ5+OR+7ENF+OR+7ENG+OR+7EPX+OR+7EY0+OR+7EY4+OR+7EY5+OR+7EYA+OR+7EZV+OR+7F3Q+OR+7F46+OR+7F62+OR+7F63+OR+7FAE+OR+7FAF+OR+7FB0+OR+7FB1+OR+7FB3+OR+7FB4+OR+7FCD+OR+7FCE+OR+7FEM+OR+7FET+OR+7FG2+OR+7FG3+OR+7FG7+OR+7FJN+OR+7FJO+OR+7JJC+OR+7JJJ+OR+7JV2+OR+7JV4+OR+7JV6+OR+7JVA+OR+7JVC+OR+7JW0+OR+7JWB+OR+7JWY+OR+7JZL+OR+7JZM+OR+7JZN+OR+7JZU+OR+7K43+OR+7K45+OR+7K4N+OR+7K8S+OR+7K8T+OR+7K8U+OR+7K8V+OR+7K8W+OR+7K8X+OR+7K8Y+OR+7K8Z+OR+7K90+OR+7K9H+OR+7K9J+OR+7KDG+OR+7KDH+OR+7KDI+OR+7KDJ+OR+7KDK+OR+7KDL+OR+7KE4+OR+7KE6+OR+7KE7+OR+7KE8+OR+7KE9+OR+7KEA+OR+7KEB+OR+7KEC+OR+7KJ2+OR+7KJ3+OR+7KJ4+OR+7KJ5+OR+7KKK+OR+7KKL+OR+7KL9+OR+7KMB+OR+7KMK+OR+7KML+OR+7KMS+OR+7KMZ+OR+7KNB+OR+7KNE+OR+7KNH+OR+7KNI+OR+7KQB+OR+7KQE+OR+7KRQ+OR+7KRR+OR+7KRS+OR+7KS9+OR+7KSG+OR+7KXJ+OR+7KXK+OR+7L02+OR+7L06+OR+7L09+OR+7L2C+OR+7L2D+OR+7L2E+OR+7L2F+OR+7L3N+OR+7L56+OR+7L57+OR+7L58+OR+7L7K+OR+7LAA+OR+7LAB+OR+7LC8+OR+7LCN+OR+7LD1+OR+7LJR+OR+7LQV+OR+7LQW+OR+7LRT+OR+7LS9+OR+7LSS+OR+7LWI+OR+7LWJ+OR+7LWK+OR+7LWL+OR+7LWM+OR+7LWN+OR+7LWO+OR+7LWP+OR+7LWQ+OR+7LWS+OR+7LWT+OR+7LWU+OR+7LWV+OR+7LWW+OR+7LX5+OR+7LXW+OR+7LXX+OR+7LXY+OR+7LXZ+OR+7LY0+OR+7LY2+OR+7LY3+OR+7LYK+OR+7LYL+OR+7LYM+OR+7LYN+OR+7LYO+OR+7LYP+OR+7LYQ+OR+7M0J+OR+7M6E+OR+7M6F+OR+7M6G+OR+7M6H+OR+7M6I+OR+7M71+OR+7M7B+OR+7M8J+OR+7M8K+OR+7M8S+OR+7M8U+OR+7MJG+OR+7MJH+OR+7MJI+OR+7MJJ+OR+7MJK+OR+7MJL+OR+7MJM+OR+7MJN+OR+7MKB+OR+7MKL+OR+7MM0+OR+7MTC+OR+7MTD+OR+7MTE+OR+7MW2+OR+7MW3+OR+7MW4+OR+7MW5+OR+7MW6+OR+7MXP+OR+7MY2+OR+7MY3+OR+7N01+OR+7N0G+OR+7N0H+OR+7N1A+OR+7N1F+OR+7N1Q+OR+7N1T+OR+7N1U+OR+7N1V+OR+7N1W+OR+7N1X+OR+7N1Y+OR+7N5H+OR+7N62+OR+7N64+OR+7N6D+OR+7N6E+OR+7N8H+OR+7N8I+OR+7N9B+OR+7N9C+OR+7N9E+OR+7N9T+OR+7ND3+OR+7ND4+OR+7ND5+OR+7ND6+OR+7ND7+OR+7ND8+OR+7ND9+OR+7NDA+OR+7NDB+OR+7NDC+OR+7NDD+OR+7NS6+OR+7NT9+OR+7NTA+OR+7NTC+OR+7NX6+OR+7NX7+OR+7NX8+OR+7NX9+OR+7NXA+OR+7NXB+OR+7NXC+OR+7NY5+OR+7OAN+OR+7OD3+OR+7ODL+OR+7P3D+OR+7P40+OR+7P5G+OR+7P77+OR+7P78+OR+7P79+OR+7P7A+OR+7P7B+OR+7PBE+OR+7Q0A+OR+7Q0I+OR+7Q1Z+OR+7Q6E+OR+7Q9F+OR+7Q9G+OR+7Q9I+OR+7Q9J+OR+7Q9K+OR+7Q9M+OR+7Q9P+OR+7QDG+OR+7QDH+OR+7QO7+OR+7QO9+OR+7QTI+OR+7QTJ+OR+7QTK+OR+7QUR+OR+7QUS+OR+7R0Z+OR+7R10+OR+7R11+OR+7R12+OR+7R13+OR+7R14+OR+7R15+OR+7R15+OR+7R16+OR+7R17+OR+7R18+OR+7R19+OR+7R1A+OR+7R1B+OR+7R40+OR+7R4I+OR+7R4Q+OR+7R4R+OR+7R7N+OR+7R8M+OR+7R8N+OR+7R8O+OR+7RA8+OR+7RAL+OR+7RBU+OR+7RBV+OR+7RKV+OR+7RQ6+OR+7RTD+OR+7RTR+OR+7RU1+OR+7RU2+OR+7RU3+OR+7RU4+OR+7RU5+OR+7RU8+OR+7RW2+OR+7S0C+OR+7S0D+OR+7S0E+OR+7S6I+OR+7S6J+OR+7S6K+OR+7S6L+OR+7SBK+OR+7SBL+OR+7SBO+OR+7SBP+OR+7SBQ+OR+7SBR+OR+7SBS+OR+7SBT+OR+7SC1+OR+7SIX+OR+7SJ0+OR+7SN2+OR+7SN3+OR+7SO9+OR+7SOA+OR+7SOB+OR+7SOC+OR+7SOD+OR+7SOE+OR+7SOF+OR+7SWW+OR+7SWX+OR+7SXR+OR+7SXS+OR+7SXT+OR+7SXU+OR+7SXV+OR+7SXW+OR+7SXX+OR+7SXY+OR+7SXZ+OR+7SY0+OR+7SY1+OR+7SY2+OR+7SY3+OR+7SY4+OR+7SY5+OR+7SY6+OR+7SY7+OR+7SY8+OR+7T3M+OR+7T67+OR+7T9J+OR+7T9K+OR+7T9L+OR+7TAS+OR+7TAT+OR+7TB4+OR+7TB8+OR+7TCA+OR+7TCC+OR+7TEI+OR+7TEW+OR+7TEX+OR+7TEY+OR+7TEZ+OR+7TF0+OR+7TF1+OR+7TF2+OR+7TF3+OR+7TF4+OR+7TF5+OR+7TF8+OR+7TGE+OR+7TGW+OR+7TGX+OR+7TGY+OR+7THK+OR+7THT+OR+7TL1+OR+7TL9+OR+7TLA+OR+7TLB+OR+7TLC+OR+7TLD+OR+7TLY+OR+7TLZ+OR+7TM0+OR+7TNW+OR+7TO4+OR+7TOU+OR+7TOV+OR+7TOX+OR+7TOY+OR+7TOZ+OR+7TP0+OR+7TP1+OR+7TP2+OR+7TP7+OR+7TP8+OR+7TP9+OR+7TPA+OR+7TPC+OR+7TPE+OR+7TPF+OR+7TPH+OR+7TPL+OR+7TPR+OR+7TYZ+OR+7TZ0+OR+7U0P+OR+7U0Q+OR+7U0X+OR+7U9O+OR+7U9P+OR+7UAP+OR+7UAQ+OR+7UAR+OR+7UHB+OR+7UHC+OR+7UKL+OR+7UKM+OR+7UOW+OR+7UPL+OR+7UPX+OR+7UZ4+OR+7UZ5+OR+7UZ6+OR+7UZ7+OR+7UZ8+OR+7UZ9+OR+7UZA+OR+7UZB+OR+7V20+OR+7V22+OR+7V23+OR+7V24+OR+7V26+OR+7V2A+OR+7V76+OR+7V77+OR+7V78+OR+7V79+OR+7V7A+OR+7V7D+OR+7V7E+OR+7V7F+OR+7V7G+OR+7V7H+OR+7V7I+OR+7V7J+OR+7V7N+OR+7V7O+OR+7V7P+OR+7V7Q+OR+7V7R+OR+7V7S+OR+7V7T+OR+7V7U+OR+7V7V+OR+7V7Z+OR+7V80+OR+7V81+OR+7V82+OR+7V83+OR+7V84+OR+7V85+OR+7V86+OR+7V87+OR+7V88+OR+7V89+OR+7V8A+OR+7V8B+OR+7V8C+OR+7VHH+OR+7VHJ+OR+7VHK+OR+7VHL+OR+7VHM+OR+7VHN+OR+7VNC+OR+7VND+OR+7VNE+OR+7VQ0+OR+7VRV+OR+7VRW+OR+7VX1+OR+7VX4+OR+7VX5+OR+7VX7+OR+7VX9+OR+7VXA+OR+7VXC+OR+7VXD+OR+7VXE+OR+7VXF+OR+7VXI+OR+7VXK+OR+7VXM+OR+7W92+OR+7W94+OR+7W98+OR+7W99+OR+7W9B+OR+7W9C+OR+7W9E+OR+7WCD+OR+7WCH+OR+7WCP+OR+7WCR+OR+7WCZ+OR+7WD0+OR+7WD7+OR+7WD8+OR+7WD9+OR+7WDF+OR+7WE7+OR+7WE8+OR+7WE9+OR+7WEA+OR+7WEB+OR+7WEC+OR+7WEE+OR+7WEV+OR+7WG6+OR+7WG7+OR+7WG8+OR+7WG9+OR+7WGB+OR+7WGC+OR+7WGV+OR+7WGX+OR+7WGY+OR+7WGZ+OR+7WHB+OR+7WHD+OR+7WHI+OR+7WHJ+OR+7WHK+OR+7WJY+OR+7WJZ+OR+7WK2+OR+7WK3+OR+7WK4+OR+7WK5+OR+7WK6+OR+7WK8+OR+7WK9+OR+7WKA+OR+7WLY+OR+7WLZ+OR+7WM0+OR+7WO4+OR+7WO5+OR+7WOA+OR+7WOB+OR+7WP9+OR+7WPA+OR+7WPB+OR+7WPC+OR+7WPD+OR+7WPE+OR+7WPF+OR+7WRH+OR+7WRI+OR+7WRV+OR+7WS0+OR+7WS1+OR+7WS3+OR+7WS4+OR+7WS5+OR+7WS8+OR+7WS9+OR+7WT7+OR+7WT8+OR+7WT9+OR+7WTF+OR+7WTK+OR+7WUH+OR+7WVN+OR+7WVO+OR+7WVP+OR+7WVQ+OR+7WWI+OR+7WWJ+OR+7WWL+OR+7WWM+OR+7WZ1+OR+7WZ2+OR+7X6A+OR+7X7N+OR+7X8W+OR+7X8Y+OR+7X8Z+OR+7X90+OR+7X91+OR+7X92+OR+7X93+OR+7X94+OR+7X95+OR+7X96+OR+7XCH+OR+7XCO+OR+7XD2+OR+7XDB+OR+7XDK+OR+7XDL+OR+7XH8+OR+7XIC+OR+7XID+OR+7XIW+OR+7XIX+OR+7XIY+OR+7XJ6+OR+7XJ8+OR+7XMX+OR+7XMZ+OR+7XNQ+OR+7XNR+OR+7XNS+OR+7XO4+OR+7XO5+OR+7XO6+OR+7XO7+OR+7XO8+OR+7XO9+OR+7XOA+OR+7XOB+OR+7XOC+OR+7XOD+OR+7XRP+OR+7XST+OR+7XTZ+OR+7XU0+OR+7XU1+OR+7XU2+OR+7XU3+OR+7XU4+OR+7XU5+OR+7XU6+OR+7XY3+OR+7XY4+OR+7Y0N+OR+7Y1Y+OR+7Y1Z+OR+7Y20+OR+7Y21+OR+7Y42+OR+7Y6D+OR+7Y6K+OR+7Y6L+OR+7Y6N+OR+7Y7J+OR+7Y9S+OR+7Y9Z+OR+7YA0+OR+7YBH+OR+7YBI+OR+7YBJ+OR+7YBK+OR+7YBL+OR+7YBM+OR+7YC5+OR+7YDY+OR+7YE5+OR+7YE9+OR+7YEG+OR+7YH7+OR+7YKJ+OR+7YQT+OR+7YQU+OR+7YQV+OR+7YQW+OR+7YQX+OR+7YQY+OR+7YQZ+OR+7YR1+OR+7YR2+OR+7YR3+OR+7YVE+OR+7YVF+OR+7YVG+OR+7YVH+OR+7YVI+OR+7YVJ+OR+7YVK+OR+7YVL+OR+7YVM+OR+7YVN+OR+7YVO+OR+7YVP+OR+7Z3Z+OR+7Z6V+OR+7Z7X+OR+7Z85+OR+7Z86+OR+7Z9Q+OR+7Z9R+OR+7ZBU+OR+7ZCE+OR+7ZCF+OR+7ZJL+OR+7ZR7+OR+7ZR8+OR+7ZR9+OR+7ZRC+OR+7ZRV+OR+7ZSS+OR+8A95+OR+8A99+OR+8AQS+OR+8AQT+OR+8AQU+OR+8AQV+OR+8AQW+OR+8BEV+OR+8BGG+OR+8BON+OR+8C1V+OR+8C8P+OR+8CIM+OR+8CSA+OR+8CSJ+OR+8CXN+OR+8CXQ+OR+8CY6+OR+8CY7+OR+8CY9+OR+8CYA+OR+8CYB+OR+8CYC+OR+8CYD+OR+8CYJ+OR+8D0Z+OR+8D48+OR+8D55+OR+8D56+OR+8D5A+OR+8D8Q+OR+8D8R+OR+8DAD+OR+8DI5+OR+8DLI+OR+8DLJ+OR+8DLK+OR+8DLL+OR+8DLM+OR+8DLN+OR+8DLO+OR+8DLP+OR+8DLQ+OR+8DLR+OR+8DLS+OR+8DLT+OR+8DLU+OR+8DLV+OR+8DLW+OR+8DLX+OR+8DLY+OR+8DLZ+OR+8DM0+OR+8DM1+OR+8DM2+OR+8DM3+OR+8DM4+OR+8DM5+OR+8DM6+OR+8DM7+OR+8DM8+OR+8DM9+OR+8DMA+OR+8DT3+OR+8DT8+OR+8DV1+OR+8DV2+OR+8DXS+OR+8DZH+OR+8DZI+OR+8ELJ+OR+8EPN+OR+8EPP+OR+8EPQ+OR+8ERQ+OR+8ERR+OR+8F0G+OR+8F0H+OR+8FEZ+OR+8FU7+OR+8FU8+OR+8FU9+OR+8GB0+OR+8GJM+OR+8GNH+OR+8GOU+OR+8GS6+OR+8GTO+OR+8GTP+OR+8GTQ+OR+8H00+OR+8H01+OR+8H07+OR+8H08+OR+8H3D+OR+8H3E+OR+8H3M+OR+8H3N+OR+8H7L+OR+8HC2+OR+8HC3+OR+8HC4+OR+8HC5+OR+8HC6+OR+8HC7+OR+8HC9+OR+8HCA+OR+8HCB+OR+8HEB+OR+8HEC+OR+8HFX+OR+8HFZ+OR+8HHX+OR+8HHY+OR+8HHZ+OR+8I3S+OR+8I3U+OR+8IFY+OR+8IOS+OR+8IOT+OR+8IOU+OR+8IOV+OR+8ITU+OR+8P99+OR+8P9Y">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6ACC"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6ACC" width="82%" height="82%" alt="Molecular structure image for 6ACC"/><br>6ACC</a> [<a href="/structure/?term=5X4S+OR+5WRG+OR+5X58+OR+5X5B+OR+5XLR+OR+6ACC+OR+6ACD+OR+6ACG+OR+6ACJ+OR+6ACK+OR+6CRV+OR+6CRW+OR+6CRX+OR+6CRZ+OR+6CS0+OR+6CS1+OR+6CS2+OR+6NB6+OR+6NB7+OR+6VW1+OR+6ZGF+OR+7AKJ+OR+7CN4+OR+7SG4+OR+7W98">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/7BBH"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=7BBH" width="82%" height="82%" alt="Molecular structure image for 7BBH"/><br>7BBH</a> [<a href="/structure/?term=7AKJ+OR+7BBH+OR+7CN8+OR+7X25">all</a>]</td>
|
|
<td><a href="/protein/YP_009724390.1">YP_009724390</a> [<a href="/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=YP_009724390.1">domain architecture</a>]</td>
|
|
<td>1273</td></tr>
|
|
|
|
<tr>
|
|
<td></td>
|
|
<td><a href="/Structure/cdd/cd21480">cd21480</a></td>
|
|
<td><span title="receptor-binding domain of the S1 subunit of severe acute respiratory syndrome coronavirus 2 Spike (S) protein. This group contains the receptor-binding domain of the S1 subunit of the spike (S) protein from highly pathogenic human virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as 2019 novel coronavirus (2019-nCoV). The CoV S protein is an envelope glycoprotein that plays the most important role in viral attachment, fusion, and entry into host cells, and serves as a major target for the development of neutralizing antibodies, inhibitors of viral entry, and vaccines. It is synthesized as a precursor protein that is cleaved into an N-terminal S1 subunit (~700 amino acids) and a C-terminal S2 subunit (~600 amino acids) that mediates attachment and membrane fusion, respectively. Three S1/S2 heterodimers assemble to form a trimer spike protruding from the viral envelope. The S1 subunit contains a receptor-binding domain (RBD), while the S2 subunit contains a hydrophobic fusion peptide and two heptad repeat regions. S1 contains two structurally independent domains, the N-terminal domain (NTD) and the C-terminal domain (C-domain). Depending on the virus, either the NTD or the C-domain can serve as the receptor-binding domain (RBD). While RBD of mouse hepatitis virus (MHV) is located at the NTD, most of other CoVs, including SARS-CoV-2 use the C-domain to bind their receptors. Recent studies found that the receptor-binding domain (RBD) of SARS-CoV-2 S protein binds strongly to human and bat angiotensin-converting enzyme 2 (ACE2) receptors. Moreover, SARS-CoV-2 RBD exhibited significantly higher binding affinity to the ACE2 receptor than SARS-CoV RBD. Due to the key role of the S protein RBD in viral attachment, it is the major target for antibody-mediated neutralization. This model corresponds to the S1 subunit C-domain that serves as the RBD for SARS-CoV-2 and most CoVs.">SARS-CoV-2_Spike_S1_RBD</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6VXX"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6VXX" width="82%" height="82%" alt="Molecular structure image for 6VXX"/><br>6VXX</a> [<a href="/structure/?term=6M0J+OR+6M17+OR+6VSB+OR+6VXX+OR+6VYB+OR+6W41+OR+6X29+OR+6X2A+OR+6X2C+OR+6X6P+OR+6X79+OR+6XC2+OR+6XC3+OR+6XC4+OR+6XC7+OR+6XCM+OR+6XCN+OR+6XDG+OR+6XE1+OR+6XEY+OR+6XF5+OR+6XF6+OR+6XKL+OR+6XKP+OR+6XKQ+OR+6XLU+OR+6XM0+OR+6XM3+OR+6XM4+OR+6XM5+OR+6XR8+OR+6XRA+OR+6XS6+OR+6YLA+OR+6YM0+OR+6YOR+OR+6YZ5+OR+6YZ7+OR+6Z2M+OR+6Z43+OR+6Z97+OR+6ZB4+OR+6ZB5+OR+6ZBP+OR+6ZCZ+OR+6ZDG+OR+6ZDH+OR+6ZER+OR+6ZFO+OR+6ZGE+OR+6ZGG+OR+6ZGH+OR+6ZGI+OR+6ZH9+OR+6ZHD+OR+6ZLR+OR+6ZOW+OR+6ZOX+OR+6ZOY+OR+6ZOZ+OR+6ZP0+OR+6ZP1+OR+6ZP2+OR+6ZP5+OR+6ZP7+OR+6ZWV+OR+6ZXN+OR+7A25+OR+7A29+OR+7A4N+OR+7A5R+OR+7A5S+OR+7A91+OR+7A92+OR+7A93+OR+7A94+OR+7A95+OR+7A96+OR+7A97+OR+7A98+OR+7AD1+OR+7AKD+OR+7B0B+OR+7B14+OR+7B17+OR+7B18+OR+7B27+OR+7B3O+OR+7BEH+OR+7BEI+OR+7BEJ+OR+7BEK+OR+7BEL+OR+7BEM+OR+7BEN+OR+7BEO+OR+7BEP+OR+7BH9+OR+7BNM+OR+7BNN+OR+7BNO+OR+7BNV+OR+7BWJ+OR+7BYR+OR+7BZ5+OR+7C01+OR+7C2L+OR+7C8D+OR+7C8J+OR+7C8V+OR+7C8W+OR+7CAB+OR+7CAC+OR+7CAH+OR+7CAI+OR+7CAK+OR+7CAN+OR+7CDI+OR+7CDJ+OR+7CH4+OR+7CH5+OR+7CHB+OR+7CHC+OR+7CHE+OR+7CHF+OR+7CHH+OR+7CHO+OR+7CHP+OR+7CHS+OR+7CJF+OR+7CM4+OR+7CN9+OR+7CT5+OR+7CWL+OR+7CWM+OR+7CWN+OR+7CWO+OR+7CWS+OR+7CWT+OR+7CWU+OR+7CYH+OR+7CYP+OR+7CYV+OR+7CZP+OR+7CZQ+OR+7CZR+OR+7CZS+OR+7CZT+OR+7CZU+OR+7CZV+OR+7CZW+OR+7CZX+OR+7CZY+OR+7CZZ+OR+7D00+OR+7D03+OR+7D0B+OR+7D0C+OR+7D0D+OR+7D2Z+OR+7D30+OR+7D6I+OR+7DCC+OR+7DCX+OR+7DD2+OR+7DD8+OR+7DDD+OR+7DDN+OR+7DEO+OR+7DET+OR+7DEU+OR+7DF3+OR+7DF4+OR+7DHX+OR+7DJZ+OR+7DK0+OR+7DK2+OR+7DK3+OR+7DK4+OR+7DK5+OR+7DK6+OR+7DK7+OR+7DMU+OR+7DPM+OR+7DQA+OR+7DWX+OR+7DWY+OR+7DWZ+OR+7DX0+OR+7DX1+OR+7DX2+OR+7DX3+OR+7DX4+OR+7DX5+OR+7DX6+OR+7DX7+OR+7DX8+OR+7DX9+OR+7DZW+OR+7DZX+OR+7DZY+OR+7E23+OR+7E39+OR+7E3B+OR+7E3C+OR+7E3J+OR+7E3K+OR+7E3L+OR+7E3O+OR+7E5O+OR+7E5R+OR+7E5S+OR+7E5Y+OR+7E7B+OR+7E7D+OR+7E7X+OR+7E7Y+OR+7E86+OR+7E88+OR+7E8C+OR+7E8F+OR+7E8M+OR+7E9N+OR+7E9O+OR+7E9P+OR+7E9Q+OR+7EAM+OR+7EAN+OR+7EAZ+OR+7EB0+OR+7EB3+OR+7EB4+OR+7EB5+OR+7EDF+OR+7EDG+OR+7EDH+OR+7EDI+OR+7EDJ+OR+7EFP+OR+7EFR+OR+7EH5+OR+7EJ4+OR+7EJ5+OR+7EJY+OR+7EJZ+OR+7EK0+OR+7EKC+OR+7EKE+OR+7EKF+OR+7EKG+OR+7EKH+OR+7ENF+OR+7ENG+OR+7EPX+OR+7EU2+OR+7EY0+OR+7EY4+OR+7EY5+OR+7EYA+OR+7EZV+OR+7F0X+OR+7F12+OR+7F15+OR+7F3Q+OR+7F46+OR+7F4W+OR+7F5G+OR+7F5H+OR+7F5R+OR+7F62+OR+7F63+OR+7F6Y+OR+7F6Z+OR+7F7E+OR+7F7H+OR+7FAE+OR+7FAF+OR+7FAT+OR+7FAU+OR+7FB0+OR+7FB1+OR+7FB3+OR+7FB4+OR+7FBJ+OR+7FBK+OR+7FC5+OR+7FCD+OR+7FCE+OR+7FCP+OR+7FCQ+OR+7FDG+OR+7FDH+OR+7FDI+OR+7FDK+OR+7FEM+OR+7FET+OR+7FG2+OR+7FG3+OR+7FG7+OR+7FH0+OR+7FJC+OR+7FJN+OR+7FJO+OR+7FJS+OR+7JJJ+OR+7JMO+OR+7JMP+OR+7JV2+OR+7JV4+OR+7JV6+OR+7JVA+OR+7JVB+OR+7JVC+OR+7JW0+OR+7JWB+OR+7JWY+OR+7JX3+OR+7JZL+OR+7JZM+OR+7JZN+OR+7JZU+OR+7K43+OR+7K45+OR+7K4N+OR+7K8M+OR+7K8S+OR+7K8T+OR+7K8U+OR+7K8V+OR+7K8W+OR+7K8X+OR+7K8Y+OR+7K8Z+OR+7K90+OR+7K9H+OR+7K9I+OR+7K9J+OR+7K9K+OR+7K9Z+OR+7KDG+OR+7KDH+OR+7KDI+OR+7KDJ+OR+7KDK+OR+7KDL+OR+7KE4+OR+7KE6+OR+7KE7+OR+7KE8+OR+7KE9+OR+7KEA+OR+7KEB+OR+7KEC+OR+7KFV+OR+7KFW+OR+7KFX+OR+7KFY+OR+7KGJ+OR+7KGK+OR+7KJ2+OR+7KJ3+OR+7KJ4+OR+7KJ5+OR+7KKK+OR+7KKL+OR+7KL9+OR+7KLG+OR+7KLH+OR+7KLW+OR+7KM5+OR+7KMB+OR+7KMG+OR+7KMH+OR+7KMI+OR+7KMK+OR+7KML+OR+7KMS+OR+7KMZ+OR+7KN3+OR+7KN4+OR+7KN5+OR+7KN6+OR+7KN7+OR+7KNB+OR+7KNE+OR+7KNH+OR+7KNI+OR+7KQB+OR+7KQE+OR+7KRQ+OR+7KRR+OR+7KRS+OR+7KS9+OR+7KSG+OR+7KXJ+OR+7KXK+OR+7KZB+OR+7L02+OR+7L06+OR+7L09+OR+7L0N+OR+7L2D+OR+7L2E+OR+7L2F+OR+7L3N+OR+7L4Z+OR+7L56+OR+7L57+OR+7L58+OR+7L5B+OR+7L7D+OR+7L7E+OR+7L7F+OR+7L7K+OR+7LAA+OR+7LAB+OR+7LCN+OR+7LD1+OR+7LDJ+OR+7LJR+OR+7LM8+OR+7LM9+OR+7LO4+OR+7LOP+OR+7LQ7+OR+7LQV+OR+7LQW+OR+7LRS+OR+7LRT+OR+7LS9+OR+7LSS+OR+7LWI+OR+7LWJ+OR+7LWK+OR+7LWL+OR+7LWM+OR+7LWN+OR+7LWO+OR+7LWP+OR+7LWQ+OR+7LWS+OR+7LWT+OR+7LWU+OR+7LWV+OR+7LWW+OR+7LX5+OR+7LXW+OR+7LXX+OR+7LXY+OR+7LXZ+OR+7LY0+OR+7LY2+OR+7LYK+OR+7LYL+OR+7LYM+OR+7LYN+OR+7LYO+OR+7LYP+OR+7LYQ+OR+7M0J+OR+7M3I+OR+7M42+OR+7M6D+OR+7M6E+OR+7M6F+OR+7M6G+OR+7M6H+OR+7M6I+OR+7M71+OR+7M7B+OR+7M7W+OR+7M8K+OR+7M8T+OR+7MDW+OR+7ME7+OR+7MEJ+OR+7MF1+OR+7MFU+OR+7MJG+OR+7MJH+OR+7MJI+OR+7MJJ+OR+7MJK+OR+7MJL+OR+7MJM+OR+7MJN+OR+7MKL+OR+7MKM+OR+7MLZ+OR+7MM0+OR+7MMO+OR+7MSQ+OR+7MTC+OR+7MTD+OR+7MTE+OR+7MW2+OR+7MW3+OR+7MW4+OR+7MW5+OR+7MW6+OR+7MXP+OR+7MY2+OR+7MY3+OR+7MZF+OR+7MZG+OR+7MZH+OR+7MZI+OR+7MZJ+OR+7MZK+OR+7MZL+OR+7MZM+OR+7MZN+OR+7N01+OR+7N0G+OR+7N0H+OR+7N1Q+OR+7N1T+OR+7N1U+OR+7N1V+OR+7N1W+OR+7N1X+OR+7N1Y+OR+7N3I+OR+7N4I+OR+7N4J+OR+7N4L+OR+7N4M+OR+7N5H+OR+7N62+OR+7N64+OR+7N8H+OR+7N8I+OR+7N9A+OR+7N9B+OR+7N9C+OR+7N9E+OR+7N9T+OR+7ND3+OR+7NEG+OR+7NEH+OR+7NKT+OR+7NLL+OR+7NP1+OR+7NS6+OR+7NY5+OR+7OAO+OR+7OAP+OR+7OAQ+OR+7OAU+OR+7OAY+OR+7OD3+OR+7ODL+OR+7OLZ+OR+7OR9+OR+7ORA+OR+7ORB+OR+7P19+OR+7P40+OR+7P5G+OR+7P5Q+OR+7P5S+OR+7PHG+OR+7PQY+OR+7PQZ+OR+7PR0+OR+7PRY+OR+7PRZ+OR+7PS0+OR+7PS1+OR+7PS2+OR+7PS4+OR+7PS5+OR+7PS6+OR+7PS7+OR+7Q0A+OR+7Q0G+OR+7Q0H+OR+7Q1Z+OR+7Q3Q+OR+7Q3R+OR+7Q6E+OR+7Q9F+OR+7Q9G+OR+7Q9I+OR+7Q9J+OR+7Q9K+OR+7Q9M+OR+7Q9P+OR+7QDG+OR+7QDH+OR+7QEZ+OR+7QF0+OR+7QF1+OR+7QNW+OR+7QNX+OR+7QNY+OR+7QO7+OR+7QO9+OR+7QTI+OR+7QTJ+OR+7QTK+OR+7QUR+OR+7QUS+OR+7R0Z+OR+7R10+OR+7R11+OR+7R12+OR+7R13+OR+7R14+OR+7R15+OR+7R15+OR+7R16+OR+7R17+OR+7R18+OR+7R19+OR+7R1A+OR+7R1B+OR+7R40+OR+7R4I+OR+7R4Q+OR+7R4R+OR+7R6W+OR+7R6X+OR+7R8L+OR+7RBY+OR+7RKU+OR+7RKV+OR+7RPV+OR+7RQ6+OR+7RR0+OR+7RU1+OR+7RU2+OR+7RU3+OR+7RU4+OR+7RU5+OR+7RU8+OR+7RW2+OR+7RXD+OR+7S0B+OR+7S0C+OR+7S0D+OR+7S0E+OR+7S4S+OR+7S5P+OR+7S5Q+OR+7S5R+OR+7S6I+OR+7S6J+OR+7S6K+OR+7S6L+OR+7S83+OR+7SBK+OR+7SBL+OR+7SBO+OR+7SBP+OR+7SBQ+OR+7SBR+OR+7SBS+OR+7SBT+OR+7SBU+OR+7SC1+OR+7SD5+OR+7SI2+OR+7SIX+OR+7SJ0+OR+7SN0+OR+7SN2+OR+7SN3+OR+7SO9+OR+7SOA+OR+7SOB+OR+7SOC+OR+7SOD+OR+7SOE+OR+7SOF+OR+7SPO+OR+7SPP+OR+7SWN+OR+7SWO+OR+7SWP+OR+7SWX+OR+7SXR+OR+7SXS+OR+7SXT+OR+7SXU+OR+7SXV+OR+7SXW+OR+7SXX+OR+7SXY+OR+7SXZ+OR+7SY0+OR+7SY1+OR+7SY2+OR+7SY3+OR+7SY4+OR+7SY5+OR+7SY6+OR+7SY7+OR+7SY8+OR+7T01+OR+7T3M+OR+7T67+OR+7T7B+OR+7T9J+OR+7T9K+OR+7T9L+OR+7TAS+OR+7TAT+OR+7TB8+OR+7TBF+OR+7TC9+OR+7TCA+OR+7TCC+OR+7TEI+OR+7TEW+OR+7TEX+OR+7TEY+OR+7TEZ+OR+7TF0+OR+7TF1+OR+7TF2+OR+7TF3+OR+7TF4+OR+7TF5+OR+7TF8+OR+7TGE+OR+7TGW+OR+7TGX+OR+7TGY+OR+7THE+OR+7THK+OR+7THT+OR+7TL1+OR+7TL9+OR+7TLA+OR+7TLB+OR+7TLC+OR+7TLD+OR+7TLT+OR+7TLY+OR+7TLZ+OR+7TM0+OR+7TN0+OR+7TNW+OR+7TO4+OR+7TOU+OR+7TOV+OR+7TOX+OR+7TOY+OR+7TOZ+OR+7TP0+OR+7TP1+OR+7TP2+OR+7TP3+OR+7TP4+OR+7TP7+OR+7TP8+OR+7TP9+OR+7TPA+OR+7TPC+OR+7TPE+OR+7TPF+OR+7TPH+OR+7TPK+OR+7TPL+OR+7TPR+OR+7TYZ+OR+7TZ0+OR+7U0D+OR+7U0N+OR+7U0P+OR+7U0Q+OR+7U0X+OR+7U8E+OR+7U9O+OR+7U9P+OR+7UAP+OR+7UAQ+OR+7UAR+OR+7UFK+OR+7UFL+OR+7UHB+OR+7UHC+OR+7UKL+OR+7UKM+OR+7UL0+OR+7UM2+OR+7UOW+OR+7UPL+OR+7UPX+OR+7UZ4+OR+7UZ5+OR+7UZ6+OR+7UZ7+OR+7UZ8+OR+7UZ9+OR+7UZA+OR+7UZB+OR+7UZC+OR+7UZD+OR+7V20+OR+7V22+OR+7V23+OR+7V24+OR+7V26+OR+7V27+OR+7V2A+OR+7V76+OR+7V77+OR+7V78+OR+7V79+OR+7V7A+OR+7V7D+OR+7V7E+OR+7V7F+OR+7V7G+OR+7V7H+OR+7V7I+OR+7V7J+OR+7V7N+OR+7V7O+OR+7V7P+OR+7V7Q+OR+7V7R+OR+7V7S+OR+7V7T+OR+7V7U+OR+7V7V+OR+7V7Z+OR+7V80+OR+7V81+OR+7V82+OR+7V83+OR+7V84+OR+7V85+OR+7V86+OR+7V87+OR+7V88+OR+7V89+OR+7V8A+OR+7V8B+OR+7V8C+OR+7VHH+OR+7VHJ+OR+7VHK+OR+7VHL+OR+7VHM+OR+7VHN+OR+7VMU+OR+7VNB+OR+7VNC+OR+7VND+OR+7VNE+OR+7VOA+OR+7VQ0+OR+7VRV+OR+7VRW+OR+7VX1+OR+7VX4+OR+7VX5+OR+7VX7+OR+7VX9+OR+7VXA+OR+7VXC+OR+7VXD+OR+7VXE+OR+7VXF+OR+7VXI+OR+7VXK+OR+7VXM+OR+7VYR+OR+7VZT+OR+7W1S+OR+7W6U+OR+7W8S+OR+7W92+OR+7W94+OR+7W98+OR+7W99+OR+7W9B+OR+7W9C+OR+7W9E+OR+7W9F+OR+7W9I+OR+7WA1+OR+7WB5+OR+7WBL+OR+7WBP+OR+7WBQ+OR+7WBZ+OR+7WCD+OR+7WCH+OR+7WCK+OR+7WCP+OR+7WCR+OR+7WCU+OR+7WCZ+OR+7WD0+OR+7WD7+OR+7WD8+OR+7WD9+OR+7WDF+OR+7WED+OR+7WEV+OR+7WG6+OR+7WG7+OR+7WG8+OR+7WG9+OR+7WGB+OR+7WGC+OR+7WGV+OR+7WGX+OR+7WGY+OR+7WGZ+OR+7WH8+OR+7WHB+OR+7WHD+OR+7WHH+OR+7WHI+OR+7WHJ+OR+7WHK+OR+7WHZ+OR+7WI0+OR+7WJY+OR+7WJZ+OR+7WK0+OR+7WK2+OR+7WK3+OR+7WK4+OR+7WK5+OR+7WK6+OR+7WK8+OR+7WK9+OR+7WKA+OR+7WLC+OR+7WLY+OR+7WLZ+OR+7WM0+OR+7WN2+OR+7WNB+OR+7WO4+OR+7WO5+OR+7WO7+OR+7WOA+OR+7WOB+OR+7WOC+OR+7WOG+OR+7WON+OR+7WP0+OR+7WP1+OR+7WP2+OR+7WP5+OR+7WP6+OR+7WP8+OR+7WP9+OR+7WPA+OR+7WPB+OR+7WPC+OR+7WPD+OR+7WPE+OR+7WPF+OR+7WPH+OR+7WQV+OR+7WR8+OR+7WRH+OR+7WRI+OR+7WRJ+OR+7WRV+OR+7WS0+OR+7WS1+OR+7WS2+OR+7WS3+OR+7WS4+OR+7WS5+OR+7WS6+OR+7WS7+OR+7WS8+OR+7WS9+OR+7WSA+OR+7WSE+OR+7WSH+OR+7WSK+OR+7WT7+OR+7WT8+OR+7WT9+OR+7WTF+OR+7WTG+OR+7WTH+OR+7WTJ+OR+7WTK+OR+7WUE+OR+7WUH+OR+7WVL+OR+7WVN+OR+7WVO+OR+7WVP+OR+7WVQ+OR+7WWI+OR+7WWJ+OR+7WWK+OR+7WWL+OR+7WWM+OR+7WZ1+OR+7WZ2+OR+7X1M+OR+7X2H+OR+7X2L+OR+7X2M+OR+7X63+OR+7X66+OR+7X6A+OR+7X7D+OR+7X7E+OR+7X7N+OR+7X7O+OR+7X7T+OR+7X7U+OR+7X8W+OR+7X8Y+OR+7X8Z+OR+7X90+OR+7X91+OR+7X92+OR+7X93+OR+7X94+OR+7X95+OR+7X96+OR+7XAZ+OR+7XB0+OR+7XB1+OR+7XBY+OR+7XCH+OR+7XCI+OR+7XCK+OR+7XCO+OR+7XCP+OR+7XCZ+OR+7XD2+OR+7XDA+OR+7XDB+OR+7XDK+OR+7XDL+OR+7XEG+OR+7XEI+OR+7XH8+OR+7XIC+OR+7XID+OR+7XIK+OR+7XIL+OR+7XIW+OR+7XIX+OR+7XIY+OR+7XIZ+OR+7XJ6+OR+7XJ8+OR+7XJ9+OR+7XMN+OR+7XMX+OR+7XMZ+OR+7XNQ+OR+7XNR+OR+7XNS+OR+7XO4+OR+7XO5+OR+7XO6+OR+7XO7+OR+7XO8+OR+7XO9+OR+7XOA+OR+7XOB+OR+7XOC+OR+7XOD+OR+7XRP+OR+7XS8+OR+7XSA+OR+7XSB+OR+7XSC+OR+7XST+OR+7XTZ+OR+7XU0+OR+7XU1+OR+7XU2+OR+7XU3+OR+7XU4+OR+7XU5+OR+7XU6+OR+7XWA+OR+7XXL+OR+7XY3+OR+7XY4+OR+7Y0C+OR+7Y0N+OR+7Y0O+OR+7Y0V+OR+7Y1Y+OR+7Y1Z+OR+7Y20+OR+7Y21+OR+7Y42+OR+7Y6D+OR+7Y6K+OR+7Y6L+OR+7Y6N+OR+7Y75+OR+7Y76+OR+7Y7J+OR+7Y7K+OR+7Y9S+OR+7Y9Z+OR+7YA0+OR+7YA1+OR+7YAD+OR+7YBH+OR+7YBI+OR+7YBJ+OR+7YBK+OR+7YBL+OR+7YBM+OR+7YC5+OR+7YCK+OR+7YCL+OR+7YCN+OR+7YCO+OR+7YD1+OR+7YDI+OR+7YDY+OR+7YE5+OR+7YE9+OR+7YEG+OR+7YH6+OR+7YH7+OR+7YHW+OR+7YJ3+OR+7YKJ+OR+7YOW+OR+7YQT+OR+7YQU+OR+7YQV+OR+7YQW+OR+7YQX+OR+7YQY+OR+7YQZ+OR+7YR0+OR+7YR1+OR+7YR2+OR+7YR3+OR+7YTN+OR+7YV8+OR+7YVE+OR+7YVF+OR+7YVG+OR+7YVH+OR+7YVI+OR+7YVJ+OR+7YVK+OR+7YVL+OR+7YVM+OR+7YVN+OR+7YVO+OR+7YVP+OR+7YVU+OR+7Z0X+OR+7Z0Y+OR+7Z1A+OR+7Z1B+OR+7Z1C+OR+7Z1D+OR+7Z1E+OR+7Z6V+OR+7Z7X+OR+7Z85+OR+7Z86+OR+7Z8O+OR+7Z9Q+OR+7Z9R+OR+7ZBU+OR+7ZCE+OR+7ZCF+OR+7ZDQ+OR+7ZF3+OR+7ZF4+OR+7ZF5+OR+7ZF7+OR+7ZF8+OR+7ZF9+OR+7ZFA+OR+7ZFB+OR+7ZFC+OR+7ZFD+OR+7ZFE+OR+7ZJL+OR+7ZR7+OR+7ZR8+OR+7ZR9+OR+7ZRC+OR+7ZRV+OR+7ZSD+OR+7ZSS+OR+7ZXU+OR+8A95+OR+8A99+OR+8AAA+OR+8AQS+OR+8AQT+OR+8AQU+OR+8AQV+OR+8AQW+OR+8BBN+OR+8BBO+OR+8BCZ+OR+8BE1+OR+8BEV+OR+8BGG+OR+8BH5+OR+8BON+OR+8BSE+OR+8BSF+OR+8C1V+OR+8C3V+OR+8C8P+OR+8CIM+OR+8CMB+OR+8CMC+OR+8CMH+OR+8CSA+OR+8CSJ+OR+8CWI+OR+8CWK+OR+8CWU+OR+8CWV+OR+8CXN+OR+8CXQ+OR+8CY6+OR+8CY7+OR+8CY9+OR+8CYA+OR+8CYB+OR+8CYC+OR+8CYD+OR+8CYJ+OR+8D0Z+OR+8D48+OR+8D55+OR+8D56+OR+8D5A+OR+8D8Q+OR+8D8R+OR+8DAD+OR+8DCC+OR+8DCE+OR+8DF5+OR+8DI5+OR+8DLI+OR+8DLJ+OR+8DLK+OR+8DLL+OR+8DLM+OR+8DLN+OR+8DLO+OR+8DLP+OR+8DLQ+OR+8DLR+OR+8DLS+OR+8DLT+OR+8DLU+OR+8DLV+OR+8DLW+OR+8DLX+OR+8DLY+OR+8DLZ+OR+8DM0+OR+8DM1+OR+8DM2+OR+8DM3+OR+8DM4+OR+8DM5+OR+8DM6+OR+8DM7+OR+8DM8+OR+8DM9+OR+8DMA+OR+8DNN+OR+8DPZ+OR+8DT3+OR+8DT8+OR+8DTK+OR+8DV1+OR+8DV2+OR+8DW2+OR+8DW3+OR+8DW9+OR+8DWA+OR+8DXS+OR+8DXT+OR+8DXU+OR+8DZH+OR+8DZI+OR+8E1G+OR+8EL2+OR+8ELJ+OR+8ELO+OR+8ELP+OR+8ELQ+OR+8EOO+OR+8EPN+OR+8EPP+OR+8EPQ+OR+8EQF+OR+8ERQ+OR+8ERR+OR+8F0G+OR+8F0H+OR+8F0I+OR+8FEZ+OR+8FU7+OR+8FU8+OR+8FU9+OR+8FXB+OR+8FXC+OR+8GB0+OR+8GB5+OR+8GB6+OR+8GB7+OR+8GB8+OR+8GF2+OR+8GJM+OR+8GJN+OR+8GNH+OR+8GOU+OR+8GPY+OR+8GRY+OR+8GS6+OR+8GS9+OR+8GSB+OR+8GTO+OR+8GTP+OR+8GTQ+OR+8GX9+OR+8GZ5+OR+8GZZ+OR+8H00+OR+8H01+OR+8H06+OR+8H07+OR+8H08+OR+8H3D+OR+8H3E+OR+8H3M+OR+8H3N+OR+8H5C+OR+8H5T+OR+8H5U+OR+8H7L+OR+8H7Z+OR+8HC2+OR+8HC3+OR+8HC4+OR+8HC5+OR+8HC6+OR+8HC7+OR+8HC8+OR+8HC9+OR+8HCA+OR+8HCB+OR+8HEB+OR+8HEC+OR+8HED+OR+8HFX+OR+8HFY+OR+8HFZ+OR+8HG0+OR+8HHX+OR+8HHY+OR+8HHZ+OR+8HN6+OR+8HN7+OR+8HR2+OR+8I3S+OR+8I3U+OR+8I5H+OR+8I5I+OR+8IDN+OR+8IF2+OR+8IFY+OR+8IFZ+OR+8IOS+OR+8IOT+OR+8IOU+OR+8IOV+OR+8ITU+OR+8IV4+OR+8IV5+OR+8IV8+OR+8IVA+OR+8J1Q+OR+8J26+OR+8P99+OR+8P9Y+OR+8S9G+OR+8SK5+OR+8SMT+OR+8SPH+OR+8SPI">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6ACC"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6ACC" width="82%" height="82%" alt="Molecular structure image for 6ACC"/><br>6ACC</a> [<a href="/structure/?term=6VW1+OR+6ZGF+OR+7CN4+OR+7RKS+OR+7SG4+OR+7W98+OR+7W9I">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/7BBH"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=7BBH" width="82%" height="82%" alt="Molecular structure image for 7BBH"/><br>7BBH</a> [<a href="/structure/?term=7BBH+OR+7DDO+OR+7DDP+OR+7X25">all</a>]</td>
|
|
<td></td>
|
|
<td></td></tr>
|
|
|
|
<tr>
|
|
<td></td>
|
|
<td><a href="/Structure/cdd/cd21698">cd21698</a></td>
|
|
<td><span title="Coronavirus S2 glycoprotein. The coronavirus spike glycoprotein forms the characteristic 'corona' after which the group is named. The Spike glycoprotein is translated as a large polypeptide that is subsequently cleaved to S1 and S2.">CoV_Spike_S1-S2_S2</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6VXX"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6VXX" width="82%" height="82%" alt="Molecular structure image for 6VXX"/><br>6VXX</a> [<a href="/structure/?term=6LVN+OR+6LXT+OR+6M1V+OR+6VSB+OR+6VXX+OR+6VYB+OR+6X29+OR+6X2A+OR+6X2C+OR+6X6P+OR+6X79+OR+6XCM+OR+6XCN+OR+6XEY+OR+6XF5+OR+6XF6+OR+6XKL+OR+6XLU+OR+6XM0+OR+6XM3+OR+6XM4+OR+6XM5+OR+6XR8+OR+6XRA+OR+6XS6+OR+6Z43+OR+6Z97+OR+6ZB4+OR+6ZB5+OR+6ZDH+OR+6ZGE+OR+6ZGG+OR+6ZGH+OR+6ZGI+OR+6ZHD+OR+6ZOW+OR+6ZOX+OR+6ZOY+OR+6ZOZ+OR+6ZP0+OR+6ZP1+OR+6ZP2+OR+6ZP5+OR+6ZP7+OR+6ZWV+OR+6ZXN+OR+7A25+OR+7A29+OR+7A4N+OR+7A5R+OR+7A5S+OR+7A93+OR+7A94+OR+7A95+OR+7A96+OR+7A97+OR+7A98+OR+7AD1+OR+7BNM+OR+7BNN+OR+7BNO+OR+7BYR+OR+7C2L+OR+7CAB+OR+7CAI+OR+7CAK+OR+7CHH+OR+7CT5+OR+7CWL+OR+7CWM+OR+7CWN+OR+7CWO+OR+7CWS+OR+7CWU+OR+7CZQ+OR+7CZR+OR+7CZS+OR+7CZT+OR+7CZU+OR+7CZV+OR+7CZW+OR+7CZX+OR+7CZY+OR+7CZZ+OR+7D00+OR+7D03+OR+7D0B+OR+7D0C+OR+7D0D+OR+7DCC+OR+7DCX+OR+7DD2+OR+7DD8+OR+7DDD+OR+7DDN+OR+7DF3+OR+7DF4+OR+7DK3+OR+7DK4+OR+7DK5+OR+7DK6+OR+7DK7+OR+7DWX+OR+7DWY+OR+7DWZ+OR+7DX0+OR+7DX1+OR+7DX2+OR+7DX3+OR+7DX5+OR+7DX6+OR+7DX7+OR+7DX8+OR+7DX9+OR+7E7B+OR+7E7D+OR+7JV2+OR+7JV4+OR+7JV6+OR+7JVA+OR+7JVC+OR+7JW0+OR+7JWB+OR+7JWY+OR+7JZL+OR+7JZM+OR+7JZN+OR+7JZU+OR+7K43+OR+7K45+OR+7K4N+OR+7K8S+OR+7K8T+OR+7K8U+OR+7K8V+OR+7K8W+OR+7K8X+OR+7K8Y+OR+7K8Z+OR+7K90+OR+7KDG+OR+7KDH+OR+7KDI+OR+7KDJ+OR+7KDK+OR+7KDL+OR+7KE4+OR+7KE6+OR+7KE7+OR+7KE8+OR+7KE9+OR+7KEA+OR+7KEB+OR+7KEC+OR+7KJ2+OR+7KJ3+OR+7KJ4+OR+7KJ5+OR+7KKK+OR+7KKL+OR+7KL9+OR+7KMB+OR+7KMK+OR+7KML+OR+7KMS+OR+7KMZ+OR+7KNB+OR+7KNE+OR+7KNH+OR+7KNI+OR+7KRQ+OR+7KRR+OR+7KRS+OR+7KS9+OR+7KSG+OR+7KXJ+OR+7KXK+OR+7L02+OR+7L06+OR+7L09+OR+7L2D+OR+7L2E+OR+7L2F+OR+7L3N+OR+7LAA+OR+7LAB+OR+7LCN+OR+7LD1+OR+7LJR+OR+7LQV+OR+7LQW+OR+7LS9+OR+7LSS+OR+7LWI+OR+7LWJ+OR+7LWK+OR+7LWL+OR+7LWM+OR+7LWN+OR+7LWO+OR+7LWP+OR+7LWQ+OR+7LWS+OR+7LWT+OR+7LWU+OR+7LWV+OR+7LWW+OR+7LYK+OR+7LYL+OR+7LYM+OR+7LYN+OR+7LYO+OR+7LYP+OR+7LYQ+OR+7M0J">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6ACC"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6ACC" width="82%" height="82%" alt="Molecular structure image for 6ACC"/><br>6ACC</a> [<a href="/structure/?term=1WNC+OR+1WYY+OR+1ZV7+OR+1ZV8+OR+1ZVA+OR+1ZVB+OR+2BEQ+OR+2BEZ+OR+2FXP+OR+2RUM+OR+2RUN+OR+2RUO+OR+5WRG+OR+5X58+OR+5X5B+OR+5XJK+OR+5XLR+OR+5ZVM+OR+6ACC+OR+6ACD+OR+6ACG+OR+6ACJ+OR+6ACK+OR+6CRV+OR+6CRW+OR+6CRX+OR+6CRZ+OR+6CS0+OR+6CS1+OR+6CS2+OR+6M3W+OR+6NB6+OR+6NB7+OR+6VW1+OR+6ZGF">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/3JCL"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=3JCL" width="82%" height="82%" alt="Molecular structure image for 3JCL"/><br>3JCL</a> [<a href="/structure/?term=1WDF+OR+1WDG+OR+2IEQ+OR+3JCL+OR+4MOD+OR+4NJL+OR+5I08+OR+5SZS+OR+5W9H+OR+5W9I+OR+5W9J+OR+5W9K+OR+5W9L+OR+5W9M+OR+5W9N+OR+5W9O+OR+5W9P+OR+5X59+OR+5X5C+OR+5X5F+OR+5YL9+OR+5ZHY+OR+5ZUV+OR+5ZVK+OR+6B3O+OR+6B7N+OR+6BFU+OR+6CV0+OR+6JX7+OR+6M15+OR+6M16+OR+6M39+OR+6NB3+OR+6NB4+OR+6NZK+OR+6OHW+OR+6PZ8+OR+6Q04+OR+6Q05+OR+6Q06+OR+6Q07+OR+6U7H+OR+6U7K+OR+6VSJ+OR+6VV5+OR+7CYC+OR+7CYD+OR+7KIP">all</a>]</td>
|
|
<td></td><td></td></tr>
|
|
|
|
<tr>
|
|
<td></td>
|
|
<td><a href="/Structure/cdd/cd22378">cd22378</a></td>
|
|
<td><span title="SD-1 and SD-2 subdomains, the S1/S2 cleavage region, and the S2 fusion subunit of the spike (S) glycoprotein from SARS-CoV-2 (COVID-19) and related betacoronaviruses in the B lineage.This group contains the SD-1 and SD-2 subdomains of the S1 subunit C-terminal domain (C-domain), the S1/S2 cleavage region, and the S2 fusion subunit of the spike (S) glycoprotein from betacoronaviruses in the sarbecovirus subgenus (B lineage), including highly pathogenic human CoVs such as Severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV), and SARS-CoV-2 (also known as a 2019 novel coronavirus or 2019-nCoV). The CoV S protein is an envelope glycoprotein that plays a very important role in viral attachment, fusion, and entry into host cells, and serves as a major target for the development of neutralizing antibodies, inhibitors of viral entry, and vaccines. It is synthesized as a precursor protein that is cleaved into an N-terminal S1 subunit (~700 amino acids) and a C-terminal S2 subunit (~600 amino acids) that mediates attachment and membrane fusion, respectively. Three S1/S2 heterodimers assemble to form a trimer spike protruding from the viral envelope. The S1 subunit contains a receptor-binding domain (RBD), while the S2 subunit contains the coronavirus fusion machinery and is primarily alpha-helical. S1 contains two structurally independent domains, the N-terminal domain (NTD) and the C-domain. The S1 C-domain also contains two subdomains (SD-1 and SD-2), which connect the S1 and S2 subunits. Depending on the virus, either the NTD or the C-domain can serve as the receptor-binding domain (RBD). While the RBD of mouse hepatitis virus (MHV) is located at the NTD, most CoVs, including SARS-CoV-2, SARS-CoV and MERS-CoV use the C-domain to bind their receptors. The S2 subunit comprises the fusion peptide (FP), a second proteolytic site (S2'), followed by an internal fusion peptide (IFP) and two heptad-repeat domains (HR1 and HR2) preceding the transmembrane domain (TM). After binding of the S1 subunit RBD on the virion to its receptor on the target cell, the HR1 and HR2 domains interact with each other to form a six-helix bundle (6-HB) fusion core, bringing viral and cellular membranes into close proximity for fusion and infection. In order to catalyze the membrane fusion reaction, CoV S needs to be primed through cleavage at the S1/S2 and S2' sites. Notably, SARS-CoV-2 has a functional polybasic (furin) cleavage site through the insertion of PRRAR*SV (* indicates the cleavage site) at the S1/S2 interface, which is absent in SARS-CoV and other SARS-related coronaviruses. The region modeled in this cd (SD-1 and SD-2, the S1/S2 cleavage region, and the S2 fusion subunit) plays an essential role in viral entry by initiating fusion of the viral and cellular membranes.">SARS-CoV-like_Spike_SD1-2_S1-S2_S2 </span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6VSB"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6VSB" width="82%" height="82%" alt="Molecular structure image for 6VSB"/><br>6VSB</a> [<a href="/structure/?term=6VSB+OR+6VXX+OR+6VYB+OR+6X29+OR+6X2A+OR+6X2C+OR+6X45+OR+6X6P+OR+6X79+OR+6XCM+OR+6XCN+OR+6XE1+OR+6XEY+OR+6XF5+OR+6XF6+OR+6XKL+OR+6XLU+OR+6XM0+OR+6XM3+OR+6XM4+OR+6XM5+OR+6XR8+OR+6XRA+OR+6XS6+OR+6YM0+OR+6Z43+OR+6Z97+OR+6ZB4+OR+6ZB5+OR+6ZDH+OR+6ZGE+OR+6ZGG+OR+6ZGH+OR+6ZGI+OR+6ZHD+OR+6ZOW+OR+6ZOX+OR+6ZOY+OR+6ZOZ+OR+6ZP0+OR+6ZP1+OR+6ZP2+OR+6ZP5+OR+6ZP7+OR+6ZWV+OR+6ZXN+OR+7A25+OR+7A29+OR+7A4N+OR+7A5R+OR+7A5S+OR+7A93+OR+7A94+OR+7A95+OR+7A96+OR+7A97+OR+7A98+OR+7AD1+OR+7AKD+OR+7B14+OR+7B18+OR+7BNM+OR+7BNN+OR+7BNO+OR+7BYR+OR+7C2L+OR+7CAB+OR+7CAI+OR+7CAK+OR+7CHH+OR+7CN4+OR+7COT+OR+7CT5+OR+7CWL+OR+7CWM+OR+7CWN+OR+7CWO+OR+7CWS+OR+7CWU+OR+7CYP+OR+7CZP+OR+7CZQ+OR+7CZR+OR+7CZS+OR+7CZT+OR+7CZU+OR+7CZV+OR+7CZW+OR+7CZX+OR+7CZY+OR+7CZZ+OR+7D00+OR+7D03+OR+7D0B+OR+7D0C+OR+7D0D+OR+7DCC+OR+7DCX+OR+7DD2+OR+7DD8+OR+7DDD+OR+7DDN+OR+7DF3+OR+7DF4+OR+7DK3+OR+7DK4+OR+7DK5+OR+7DK6+OR+7DK7+OR+7DWX+OR+7DWY+OR+7DWZ+OR+7DX0+OR+7DX1+OR+7DX2+OR+7DX3+OR+7DX5+OR+7DX6+OR+7DX7+OR+7DX8+OR+7DX9+OR+7DZW+OR+7DZX+OR+7DZY+OR+7E3K+OR+7E3L+OR+7E5R+OR+7E5S+OR+7E7B+OR+7E7D+OR+7E8C+OR+7E9N+OR+7E9O+OR+7E9P+OR+7E9Q+OR+7E9T+OR+7EAZ+OR+7EB0+OR+7EB3+OR+7EB4+OR+7EB5+OR+7EDF+OR+7EDG+OR+7EDH+OR+7EDI+OR+7EDJ+OR+7EH5+OR+7EJ4+OR+7EJ5+OR+7EJL+OR+7EK6+OR+7ENF+OR+7ENG+OR+7EPX+OR+7EY0+OR+7EY4+OR+7EY5+OR+7EYA+OR+7EZV+OR+7F3Q+OR+7F46+OR+7F62+OR+7F63+OR+7FAE+OR+7FAF+OR+7FB0+OR+7FB1+OR+7FB3+OR+7FB4+OR+7FCD+OR+7FCE+OR+7FCP+OR+7FEM+OR+7FET+OR+7FG2+OR+7FG3+OR+7FG7+OR+7FJN+OR+7FJO+OR+7JJI+OR+7JV2+OR+7JV4+OR+7JV6+OR+7JVA+OR+7JVC+OR+7JW0+OR+7JWB+OR+7JWY+OR+7JZL+OR+7JZM+OR+7JZN+OR+7JZU+OR+7K43+OR+7K45+OR+7K4N+OR+7K8S+OR+7K8T+OR+7K8U+OR+7K8V+OR+7K8W+OR+7K8X+OR+7K8Y+OR+7K8Z+OR+7K90+OR+7K9H+OR+7K9J+OR+7K9Z+OR+7KDH+OR+7KDI+OR+7KDJ+OR+7KDK+OR+7KDL+OR+7KE4+OR+7KE6+OR+7KE7+OR+7KE8+OR+7KE9+OR+7KEA+OR+7KEB+OR+7KEC+OR+7KJ2+OR+7KJ3+OR+7KJ4+OR+7KJ5+OR+7KKK+OR+7KKL+OR+7KL9+OR+7KMB+OR+7KMK+OR+7KML+OR+7KMS+OR+7KMZ+OR+7KNB+OR+7KNE+OR+7KNH+OR+7KNI+OR+7KQB+OR+7KQE+OR+7KRQ+OR+7KRR+OR+7KRS+OR+7KS9+OR+7KSG+OR+7KXJ+OR+7KXK+OR+7L02+OR+7L06+OR+7L09+OR+7L2D+OR+7L2E+OR+7L2F+OR+7L3N+OR+7L56+OR+7L57+OR+7L58+OR+7LAA+OR+7LAB+OR+7LCN+OR+7LD1+OR+7LJR+OR+7LQV+OR+7LQW+OR+7LRT+OR+7LS9+OR+7LSS+OR+7LWI+OR+7LWJ+OR+7LWK+OR+7LWL+OR+7LWM+OR+7LWN+OR+7LWO+OR+7LWP+OR+7LWQ+OR+7LWS+OR+7LWT+OR+7LWU+OR+7LWV+OR+7LWW+OR+7LX5+OR+7LXW+OR+7LXX+OR+7LXY+OR+7LXZ+OR+7LY0+OR+7LY2+OR+7LYK+OR+7LYL+OR+7LYM+OR+7LYN+OR+7LYO+OR+7LYP+OR+7LYQ+OR+7M0J+OR+7M53+OR+7M6E+OR+7M6F+OR+7M6G+OR+7M6H+OR+7M6I+OR+7M71+OR+7M7B+OR+7M8K+OR+7MJG+OR+7MJH+OR+7MJI+OR+7MJJ+OR+7MJK+OR+7MJL+OR+7MJM+OR+7MJN+OR+7MM0+OR+7MTC+OR+7MTD+OR+7MTE+OR+7MW2+OR+7MW3+OR+7MW4+OR+7MW5+OR+7MW6+OR+7MXP+OR+7MY2+OR+7MY3+OR+7MY8+OR+7N01+OR+7N0G+OR+7N0H+OR+7N1B+OR+7N1E+OR+7N1Q+OR+7N1T+OR+7N1U+OR+7N1V+OR+7N1W+OR+7N1X+OR+7N1Y+OR+7N5H+OR+7N62+OR+7N64+OR+7N8H+OR+7N8I+OR+7N9B+OR+7N9C+OR+7N9E+OR+7NAB+OR+7ND3+OR+7ND4+OR+7ND5+OR+7ND6+OR+7ND7+OR+7ND8+OR+7ND9+OR+7NDA+OR+7NDB+OR+7NDC+OR+7NDD+OR+7NS6+OR+7NT9+OR+7NTA+OR+7NTC+OR+7NY5+OR+7OAN+OR+7OD3+OR+7ODL+OR+7OWX+OR+7P40+OR+7P5G+OR+7P77+OR+7P78+OR+7P79+OR+7P7A+OR+7P7B+OR+7Q0A+OR+7Q1Z+OR+7Q6E+OR+7Q9F+OR+7Q9G+OR+7Q9I+OR+7Q9J+OR+7Q9K+OR+7Q9M+OR+7Q9P+OR+7QDG+OR+7QDH+OR+7QO7+OR+7QO9+OR+7QTI+OR+7QTJ+OR+7QTK+OR+7QUR+OR+7QUS+OR+7R0Z+OR+7R10+OR+7R11+OR+7R12+OR+7R13+OR+7R14+OR+7R15+OR+7R15+OR+7R16+OR+7R17+OR+7R18+OR+7R19+OR+7R1A+OR+7R1B+OR+7R40+OR+7R4I+OR+7R4Q+OR+7R4R+OR+7R7N+OR+7R8M+OR+7R8N+OR+7R8O+OR+7R95+OR+7RA8+OR+7RAL+OR+7RAQ+OR+7RKV+OR+7RNJ+OR+7RQ6+OR+7RU1+OR+7RU2+OR+7RU3+OR+7RU4+OR+7RU5+OR+7RU8+OR+7RW2+OR+7RZQ+OR+7RZR+OR+7RZS+OR+7RZT+OR+7RZU+OR+7RZV+OR+7S0C+OR+7S0D+OR+7S0E+OR+7S3N+OR+7S6I+OR+7S6J+OR+7S6K+OR+7S6L+OR+7SA2+OR+7SBK+OR+7SBL+OR+7SBO+OR+7SBP+OR+7SBQ+OR+7SBR+OR+7SBS+OR+7SBT+OR+7SC1+OR+7SIS+OR+7SIX+OR+7SJ0+OR+7SJS+OR+7SKZ+OR+7SL5+OR+7SN2+OR+7SN3+OR+7SO9+OR+7SOA+OR+7SOB+OR+7SOC+OR+7SOD+OR+7SOE+OR+7SOF+OR+7SWX+OR+7SXR+OR+7SXS+OR+7SXT+OR+7SXU+OR+7SXV+OR+7SXW+OR+7SXX+OR+7SXY+OR+7SXZ+OR+7SY0+OR+7SY1+OR+7SY2+OR+7SY3+OR+7SY4+OR+7SY5+OR+7SY6+OR+7SY7+OR+7SY8+OR+7T3M+OR+7T67+OR+7T9J+OR+7T9K+OR+7T9L+OR+7TAS+OR+7TAT+OR+7TB4+OR+7TB8+OR+7TCA+OR+7TCC+OR+7TCQ+OR+7TEI+OR+7TEW+OR+7TEX+OR+7TEY+OR+7TEZ+OR+7TF0+OR+7TF1+OR+7TF2+OR+7TF3+OR+7TF4+OR+7TF5+OR+7TF8+OR+7TGE+OR+7TGW+OR+7TGX+OR+7TGY+OR+7THK+OR+7THT+OR+7TIK+OR+7TL1+OR+7TL9+OR+7TLA+OR+7TLB+OR+7TLC+OR+7TLD+OR+7TLY+OR+7TLZ+OR+7TM0+OR+7TNW+OR+7TO4+OR+7TOU+OR+7TOV+OR+7TOW+OR+7TOX+OR+7TOY+OR+7TOZ+OR+7TP0+OR+7TP1+OR+7TP2+OR+7TP7+OR+7TP8+OR+7TP9+OR+7TPA+OR+7TPC+OR+7TPE+OR+7TPF+OR+7TPH+OR+7TPL+OR+7TPR+OR+7TYZ+OR+7TZ0+OR+7U09+OR+7U0A+OR+7U0E+OR+7U0P+OR+7U0Q+OR+7U0X+OR+7U1R+OR+7U9O+OR+7U9P+OR+7UAP+OR+7UAQ+OR+7UAR+OR+7UHB+OR+7UHC+OR+7UKL+OR+7UKM+OR+7UL0+OR+7UOW+OR+7UPL+OR+7UPX+OR+7UR1+OR+7UZ4+OR+7UZ5+OR+7UZ6+OR+7UZ7+OR+7UZ8+OR+7UZ9+OR+7UZA+OR+7UZB+OR+7V20+OR+7V22+OR+7V23+OR+7V24+OR+7V26+OR+7V2A+OR+7V76+OR+7V77+OR+7V78+OR+7V79+OR+7V7A+OR+7V7D+OR+7V7E+OR+7V7F+OR+7V7G+OR+7V7H+OR+7V7I+OR+7V7J+OR+7V7N+OR+7V7O+OR+7V7P+OR+7V7Q+OR+7V7R+OR+7V7S+OR+7V7T+OR+7V7U+OR+7V7V+OR+7V7Z+OR+7V80+OR+7V81+OR+7V82+OR+7V83+OR+7V84+OR+7V85+OR+7V86+OR+7V87+OR+7V88+OR+7V89+OR+7V8A+OR+7V8B+OR+7V8C+OR+7VHH+OR+7VHJ+OR+7VHK+OR+7VHL+OR+7VHM+OR+7VHN+OR+7VNC+OR+7VND+OR+7VNE+OR+7VQ0+OR+7VRV+OR+7VRW+OR+7VX1+OR+7VX4+OR+7VX5+OR+7VX7+OR+7VX9+OR+7VXA+OR+7VXC+OR+7VXD+OR+7VXE+OR+7VXF+OR+7VXI+OR+7VXK+OR+7VXM+OR+7W92+OR+7W94+OR+7W98+OR+7W99+OR+7W9B+OR+7W9C+OR+7W9E+OR+7WCD+OR+7WCH+OR+7WCP+OR+7WCR+OR+7WCZ+OR+7WD0+OR+7WD7+OR+7WD8+OR+7WD9+OR+7WDF+OR+7WEV+OR+7WG6+OR+7WG7+OR+7WG8+OR+7WG9+OR+7WGB+OR+7WGC+OR+7WGV+OR+7WGX+OR+7WGY+OR+7WGZ+OR+7WH8+OR+7WHB+OR+7WHD+OR+7WHI+OR+7WHJ+OR+7WHK+OR+7WJY+OR+7WJZ+OR+7WK2+OR+7WK3+OR+7WK4+OR+7WK5+OR+7WK6+OR+7WK8+OR+7WK9+OR+7WKA+OR+7WLY+OR+7WLZ+OR+7WM0+OR+7WO4+OR+7WO5+OR+7WOA+OR+7WOB+OR+7WP8+OR+7WP9+OR+7WPA+OR+7WPB+OR+7WPC+OR+7WPD+OR+7WPE+OR+7WPF+OR+7WRH+OR+7WRI+OR+7WRV+OR+7WS0+OR+7WS1+OR+7WS3+OR+7WS4+OR+7WS5+OR+7WS8+OR+7WS9+OR+7WT7+OR+7WT8+OR+7WT9+OR+7WTF+OR+7WTK+OR+7WUH+OR+7WVN+OR+7WVO+OR+7WVP+OR+7WVQ+OR+7WWI+OR+7WWJ+OR+7WWL+OR+7WWM+OR+7WXZ+OR+7WZ1+OR+7WZ2+OR+7X6A+OR+7X7N+OR+7X8W+OR+7X8Y+OR+7X8Z+OR+7X90+OR+7X91+OR+7X92+OR+7X93+OR+7X94+OR+7X95+OR+7X96+OR+7X9E+OR+7XCH+OR+7XCK+OR+7XCO+OR+7XD2+OR+7XDB+OR+7XDK+OR+7XDL+OR+7XH8+OR+7XIC+OR+7XID+OR+7XIW+OR+7XIX+OR+7XIY+OR+7XIZ+OR+7XJ6+OR+7XJ8+OR+7XMX+OR+7XMZ+OR+7XNQ+OR+7XNR+OR+7XNS+OR+7XO4+OR+7XO5+OR+7XO6+OR+7XO7+OR+7XO8+OR+7XO9+OR+7XOA+OR+7XOB+OR+7XOC+OR+7XOD+OR+7XSA+OR+7XSB+OR+7XST+OR+7XTZ+OR+7XU0+OR+7XU1+OR+7XU2+OR+7XU3+OR+7XU4+OR+7XU5+OR+7XU6+OR+7XY3+OR+7XY4+OR+7Y0N+OR+7Y1Y+OR+7Y1Z+OR+7Y20+OR+7Y21+OR+7Y42+OR+7Y6D+OR+7Y6K+OR+7Y6L+OR+7Y6N+OR+7Y7J+OR+7Y8J+OR+7Y9N+OR+7Y9S+OR+7Y9Z+OR+7YA0+OR+7YBH+OR+7YBI+OR+7YBJ+OR+7YBK+OR+7YBL+OR+7YBM+OR+7YC5+OR+7YDY+OR+7YE5+OR+7YE9+OR+7YEG+OR+7YH7+OR+7YKJ+OR+7YQT+OR+7YQU+OR+7YQV+OR+7YQW+OR+7YQX+OR+7YQY+OR+7YQZ+OR+7YR1+OR+7YR2+OR+7YR3+OR+7YUE+OR+7YVE+OR+7YVF+OR+7YVG+OR+7YVH+OR+7YVI+OR+7YVJ+OR+7YVK+OR+7YVL+OR+7YVM+OR+7YVN+OR+7YVO+OR+7YVP+OR+7Z6V+OR+7Z7X+OR+7Z85+OR+7Z86+OR+7Z9Q+OR+7Z9R+OR+7ZBU+OR+7ZCE+OR+7ZCF+OR+7ZJL+OR+7ZR2+OR+7ZR7+OR+7ZR8+OR+7ZR9+OR+7ZRC+OR+7ZRV+OR+7ZSS+OR+8A95+OR+8A99+OR+8AQS+OR+8AQT+OR+8AQU+OR+8AQV+OR+8AQW+OR+8BEV+OR+8BGG+OR+8BON+OR+8C1V+OR+8C8P+OR+8CIM+OR+8CMD+OR+8CMI+OR+8CSA+OR+8CSJ+OR+8CXN+OR+8CXQ+OR+8CY6+OR+8CY7+OR+8CY9+OR+8CYA+OR+8CYB+OR+8CYC+OR+8CYD+OR+8CYJ+OR+8CZI+OR+8D0Z+OR+8D36+OR+8D48+OR+8D55+OR+8D56+OR+8D5A+OR+8D6Z+OR+8D8Q+OR+8D8R+OR+8DAD+OR+8DAO+OR+8DGU+OR+8DI5+OR+8DLI+OR+8DLJ+OR+8DLK+OR+8DLL+OR+8DLM+OR+8DLN+OR+8DLO+OR+8DLP+OR+8DLQ+OR+8DLR+OR+8DLS+OR+8DLT+OR+8DLU+OR+8DLV+OR+8DLW+OR+8DLX+OR+8DLY+OR+8DLZ+OR+8DM0+OR+8DM1+OR+8DM2+OR+8DM3+OR+8DM4+OR+8DM5+OR+8DM6+OR+8DM7+OR+8DM8+OR+8DM9+OR+8DMA+OR+8DT3+OR+8DT8+OR+8DTR+OR+8DTT+OR+8DTX+OR+8DV1+OR+8DV2+OR+8DXS+OR+8DYA+OR+8DZH+OR+8DZI+OR+8E1G+OR+8ELH+OR+8ELJ+OR+8EPN+OR+8EPP+OR+8EPQ+OR+8ERQ+OR+8ERR+OR+8F0G+OR+8F0H+OR+8FA1+OR+8FA2+OR+8FDW+OR+8FEZ+OR+8FU7+OR+8FU8+OR+8FU9+OR+8GB0+OR+8GJM+OR+8GNH+OR+8GOM+OR+8GON+OR+8GOU+OR+8GS6+OR+8GTO+OR+8GTP+OR+8GTQ+OR+8H00+OR+8H01+OR+8H07+OR+8H08+OR+8H3D+OR+8H3E+OR+8H3M+OR+8H3N+OR+8H7L+OR+8HC2+OR+8HC3+OR+8HC4+OR+8HC5+OR+8HC6+OR+8HC7+OR+8HC9+OR+8HCA+OR+8HCB+OR+8HEB+OR+8HEC+OR+8HFX+OR+8HFZ+OR+8HHX+OR+8HHY+OR+8HHZ+OR+8I3S+OR+8I3U+OR+8IFY+OR+8IOS+OR+8IOT+OR+8IOU+OR+8IOV+OR+8ITU+OR+8P99+OR+8P9Y">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/5WRG"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=5WRG" width="82%" height="82%" alt="Molecular structure image for 5WRG"/><br>5WRG</a> [<a href="/structure/?term=5WRG+OR+5X58+OR+6ACC+OR+6CRV+OR+6CRW+OR+6NB6+OR+6VSB+OR+7SG4+OR+7W98">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/7BBH"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=7BBH" width="82%" height="82%" alt="Molecular structure image for 7BBH"/><br>7BBH</a> [<a href="/structure/?term=7BBH+OR+7CN8+7X25">all</a>]</td>
|
|
<td></td><td></td></tr>
|
|
|
|
<tr>
|
|
<td>(E)nvelope</td>
|
|
<td><a href="/Structure/cdd/cd21531">cd21531</a></td>
|
|
<td><span title="Coronavirus Envelope (E) small membrane protein. This family contains the Envelope (E) small membrane protein of betacoronaviruses, including the E proteins from three highly pathogenic human coronaviruses (CoVs) such as Middle East respiratory syndrome (MERS) CoV, Severe acute respiratory syndrome (SARS) CoV, and SARS-CoV-2, also known as 2019 novel CoV (2019-nCoV) or COVID-19 virus. There are five essential genes in CoVs that result in the following gene products: Spike (S) protein, Membrane (M) glycoprotein, Nucleocapsid (N), Envelope (E) protein, and the Orf1ab (a large polyprotein known as replicase/protease); all are required to produce a structurally complete viral particle. The E protein is a small polypeptide (76-109 amino acids) that contains a single alpha-helical transmembrane domain. It plays a central role in virus morphogenesis and assembly. It acts as a viroporin and self-assembles in host membranes forming homopentameric protein-lipid pores that allow ion transport with poor selectivity. For some CoVs, such as mouse hepatitis virus (MHV) and SARS-CoV, deletion of the E gene did not completely abolish replication, but the virions were severely disabled from infecting new host cells with significantly reduced viral titers. In animal models, SARS-CoV lacking the E gene also showed significantly attenuated viral titers, likely due to its deficiency in suppressing host stress response and apoptosis induction. Moreover, the PDZ-binding motif (PBM) at the C-terminus of SARS-CoV E protein was shown to interact with a host PDZ protein called syntenin and lead to its relocation from nucleus to cytoplasm during SARS-CoV infection, thereby activating p38 kinase to induce the overexpression of inflammatory cytokines. Thus, the E protein is involved in both, viral replication and pathogenesis during CoV infection.">SARS-like-CoV_E</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/7K3G"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=7K3G" width="82%" height="82%" alt="Molecular structure image for 7K3G"/><br>7K3G</a> [<a href="/structure/?term=7K3G+OR+7M4R+OR+7NTK+OR+7QCR+OR+7QCS+OR+7QCT+OR+7TUQ+OR+7TV0">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/5X29"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=5X29" width="82%" height="82%" alt="Molecular structure image for 5X29"/><br>5X29</a> [<a href="/structure/?term=2MM4+OR+5X29+OR+5XER+OR+5XES+OR+7NTJ">all</a>]</td>
|
|
<td>-</td>
|
|
<td><a href="/protein/YP_009724392.1">YP_009724392</a> [<a href="/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=YP_009724392.1">domain architecture</a>]</td><td>75</td></tr>
|
|
|
|
<tr><td>(M)embrane</td>
|
|
<td><a href="/Structure/cdd/cd21529">cd21529</a></td>
|
|
<td><span title="coronavirus Membrane (or Matrix) protein. This family contains the Membrane (M) protein of coronaviruses (CoVs) including three highly pathogenic human CoVs such as Middle East respiratory syndrome (MERS)-related CoV, severe acute respiratory syndrome (SARS) CoV, and SARS-CoV-2, also known as 2019 novel CoV (2019-nCoV) or COVID-19 virus. There are five essential genes in CoVs that result in the following gene products: Spike (S) protein, Membrane (M) glycoprotein, Nucleocapsid (N), Envelope (E) protein, and the Orf1ab (a large polyprotein known as replicase/protease); all are required to produce a structurally complete viral particle. The M protein, a triple-spanning membrane protein, is the most abundant protein in the virion. It plays a central role in virion assembly and morphogenesis, and it defines the shape of the viral envelope. It is regarded as the central organizer of CoV assembly, interacting with all other major coronaviral structural proteins and turning cellular membranes into workshops where virus and host factors come together to make new virus particles. While homotypic interactions between the M proteins are the major driving force behind virion envelope formation, it needs to interact with other coronaviral structural proteins for complete virion formation. The interaction of the Spike protein with M is not required for the assembly process. However, binding of M to N protein stabilizes the nucleocapsid (N protein-RNA complex), as well as the internal core of virions, and thereby promotes completion of viral assembly. Thus, the M protein, and its interactions with other structural proteins, is necessary for the production and release of virus-like particles.">SARS-like-CoV_M</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/8CTK"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=8CTK" width="82%" height="82%" alt="Molecular structure image for 8CTK"/><br>8CTK</a> [<a href="/structure/?term=7VGR+OR+7VGS+OR+8CME+OR+8CTK">all</a>]</td>
|
|
<td>-</td>
|
|
<td>-</td>
|
|
<td><a href="/protein/YP_009724393.1">YP_009724393</a> [<a href="/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=YP_009724393">domain architecture</a>]</td><td>222</td></tr>
|
|
|
|
<tr><td>(N)ucleocapsid </td>
|
|
<td><a href="/Structure/cdd/cd21554">cd21554</a></td>
|
|
<td><span title="N-terminal domain of nucleocapsid (N) protein of coronavirus. The coronavirus nucleocapsid (N) protein is a major structural and multifunctional protein. It plays an important role in the virus replication cycle, by forming a complex with the viral RNA through its N-terminal domain (N-NTD), which makes this domain an important drug target. It also interacts with the viral membrane protein during virion assembly and plays a critical role in enhancing the efficiency of virus transcription and assembly.">CoV_N-NTD</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6VYO"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6VYO" width="82%" height="82%" alt="Molecular structure image for 6VYO"/><br>6VYO</a> [<a href="/structure/?term=6M3M+OR+6VYO+OR+6WKP+OR+6YI3+OR+7ACS+OR+7ACT+OR+7CDZ+OR+7CR5+OR+7KGR+OR+7KGS+OR+7LG0+OR+7LGD+OR+7N0R+OR+7N0S+OR+7N3C+OR+7N3D+OR+7R98+OR+7SD4+OR+7STR+OR+7STS+OR+7SUE+OR+7UXX+OR+7UXZ+OR+7VNU+OR+7WZO+OR+7XXK+OR+7YLB+OR+8FD5+OR+8FG2">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/1SSK"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=1SSK" width="82%" height="82%" alt="Molecular structure image for 1SSK"/><br>1SSK</a> [<a href="/structure/?term=1SSK+OR+2OFZ+OR+2OG3+OR+7VBD">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/4UD1"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=4UD1" width="82%" height="82%" alt="Molecular structure image for 4UD1"/><br>4UD1</a> [<a href="/structure/?term=2BTL+OR+2BXX+OR+2C86+OR+2GEC+OR+3HD4+OR+4J3K+OR+4KXJ+OR+4LI4+OR+4LM7+OR+4LM9+OR+4LMC+OR+4LMT+OR+4UD1+OR+5N4K+OR+6KL2+OR+6KL5+OR+6KL6+OR+6LNN+OR+6LZ8+OR+7LGT">all</a>]</td>
|
|
<td><a href="/protein/YP_009724397.2">YP_009724397</a> [<a href="/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=YP_009724397">domain architecture</a>]</td><td>419</td></tr>
|
|
<tr><td></td>
|
|
<td><a href="/Structure/cdd/cd21595">cd21595</a></td>
|
|
<td><span title="C-terminal domain of nucleocapsid (N) protein of coronavirus. The coronavirus nucleocapsid (N) protein is a major structural and multifunctional protein. It plays an important role in the virus replication cycle, by forming a complex with the viral RNA. It also interacts with the viral membrane protein during virion assembly and plays a critical role in enhancing the efficiency of virus transcription and assembly. The C-terminal domain of the N protein (N-CTD) is involved in dimerization, and is thus, also called the dimerization domain.">CoV_N-CTD</span></td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6WJI"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6WJI" width="82%" height="82%" alt="Molecular structure image for 6WJI"/><br>6WJI</a> [<a href="/structure/?term=6WJI+OR+6WZO+OR+6WZQ+OR+6YUN+OR+6ZCO+OR+7C22+OR+7CE0+OR+7DE1+OR+7F2B+OR+7F2E+OR+7KGO+OR+7KGP+OR+7N0I+OR+7O05+OR+7O35+OR+7O36+OR+7VBE+OR+7VBF+OR+7XWX+OR+7XWZ+OR+7XX1+OR+8FD5+OR+8FG2">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/2GIB"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=2GIB" width="82%" height="82%" alt="Molecular structure image for 2GIB"/><br>2GIB</a> [<a href="/structure/?term=2CJR+OR+2GIB+OR+2JW8">all</a>]</td>
|
|
<td style="white-space:nowrap;"><a href="/Structure/pdb/6G13"><img src="/Structure/mmdb/mmdbimage.fcgi?small=t&id=6G13" width="82%" height="82%" alt="Molecular structure image for 6G13"/><br>6G13</a> [<a href="/structure/?term=2CA1+OR+2GE7+OR+2GE8+OR+5EPW+OR+6G13">all</a>]</td>
|
|
<td></td><td></td></tr></tbody></table></div>
|
|
|
|
Revised 25 October 2023
|
|
</div>
|
|
</div>
|
|
|
|
<!-- End of Real content-->
|
|
<div class="us">
|
|
<footer class="usa-footer usa-footer-big ncbi-footer" role="contentinfo">
|
|
<div class="usa-grid">
|
|
<div class="usa-row">
|
|
<nav class="usa-footer-nav">
|
|
<ul class="usa-unstyled-list usa-width-one-fourth usa-footer-primary-content">
|
|
<li class="usa-footer-primary-link ncbi-footer-heading">
|
|
<h4>Popular</h4>
|
|
</li>
|
|
<li><a href="/pubmed/">PubMed</a></li>
|
|
<li><a href="/pmc/">PMC</a></li>
|
|
<li><a href="/pubmedhealth/">PubMed Health</a></li>
|
|
<li><a href="/books/">Bookshelf</a></li>
|
|
<li><a href="https://pubchem.ncbi.nlm.nih.gov">PubChem</a></li>
|
|
<li><a href="https://blast.ncbi.nlm.nih.gov">BLAST</a></li>
|
|
<li><a href="/gene">Gene</a></li>
|
|
<li><a href="/nucleotide/">Nucleotide</a></li>
|
|
<li><a href="/protein/">Protein</a></li>
|
|
</ul>
|
|
<ul class="usa-unstyled-list usa-width-one-fourth usa-footer-primary-content">
|
|
<li class="usa-footer-primary-link ncbi-footer-heading"><h4>Connect</h4></li>
|
|
<li><a href="https://www.facebook.com/ncbi.nlm"><i aria-hidden="true"
|
|
class="fa fa-facebook fa-lg"></i>Facebook</a>
|
|
</li>
|
|
<li><a href="https://twitter.com/ncbi"><i aria-hidden="true" class="fa fa-twitter fa-lg"></i>Twitter</a>
|
|
</li>
|
|
<li>
|
|
<a href="https://www.linkedin.com/company/national-center-for-biotechnology-information-ncbi-"><i
|
|
aria-hidden="true" class="fa fa-linkedin fa-lg"></i>LinkedIn</a></li>
|
|
<li><a href="https://www.youtube.com/user/NCBINLM"><i aria-hidden="true"
|
|
class="fa fa-youtube fa-lg"></i>YouTube</a>
|
|
</li>
|
|
<li><a href="https://github.com/ncbi"><i aria-hidden="true" class="fa fa-github fa-lg"></i>GitHub</a>
|
|
</li>
|
|
<li><a href="/news/announcements-list"><i aria-hidden="true"
|
|
class="fa fa-rss"></i>News
|
|
RSS</a></li>
|
|
<li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/"><i aria-hidden="true"
|
|
class="fa fa-comments"></i>Blog</a></li>
|
|
<li><a href="/home/about/contact.shtml"><i aria-hidden="true"
|
|
class="fa fa-envelope"></i>Contact</a>
|
|
</li>
|
|
<li><a href="https://support.ncbi.nlm.nih.gov/"><i aria-hidden="true"
|
|
class="fa fa-question-circle"></i>Support
|
|
Center</a>
|
|
</li>
|
|
</ul>
|
|
<ul class="usa-unstyled-list usa-width-one-fourth usa-footer-primary-content">
|
|
<li class="usa-footer-primary-link ncbi-footer-heading"><h4>Resources</h4></li>
|
|
<li><a href="/home/literature.shtml">Literature</a></li>
|
|
<li><a href="/home/health.shtml">Health</a></li>
|
|
<li><a href="/home/genomes.shtml">Genomes</a></li>
|
|
<li><a href="/home/genes.shtml">Genes</a></li>
|
|
<li><a href="/home/proteins.shtml">Proteins</a></li>
|
|
<li><a href="/home/chemicals.shtml">Chemicals</a></li>
|
|
</ul>
|
|
<ul class="usa-unstyled-list usa-width-one-fourth usa-footer-primary-content">
|
|
<li class="usa-footer-primary-link ncbi-footer-heading"><h4>Actions</h4></li>
|
|
<li><a href="/home/submit.shtml">Submit</a></li>
|
|
<li><a href="/home/download.shtml">Download</a></li>
|
|
<li><a href="/home/learn.shtml">Learn</a></li>
|
|
<li><a href="/home/develop.shtml">Develop</a></li>
|
|
<li><a href="/home/analyze.shtml">Analyze</a></li>
|
|
<li><a href="/research/">Research</a></li>
|
|
</ul>
|
|
</nav>
|
|
|
|
<div class="usa-footer-logo usa-width-one-half">
|
|
<h3 class="ncbi"><a href="/">National Center for Biotechnology
|
|
Information</a></h3>
|
|
<address>
|
|
<span class="h-adr">
|
|
<span class="p-street-address">8600 Rockville Pike</span>,
|
|
<span class="p-locality">Bethesda</span>
|
|
<span class="p-region"> MD</span>,
|
|
<span class="p-postal-code">20894</span>
|
|
<span class="p-country-name">USA</span>
|
|
</span>
|
|
</address>
|
|
</div>
|
|
</div>
|
|
</div>
|
|
|
|
<div class="usa-grid">
|
|
<div class="usa-row">
|
|
<div class="usa-width-one-half">
|
|
<div class="org-section">
|
|
<a href="https://www.hhs.gov/"><img alt="U.S. Department of Health & Human Services"
|
|
class="usa-footer-logo-img hhs-logo"
|
|
src="/Structure/sparcle/uswds/resources/dhhs-logo-white.svg">
|
|
<span class="usa-sr-only">Department of Health and Human Services</span>
|
|
</a>
|
|
<a href="https://www.nih.gov/"><img alt="National Institutes of Health"
|
|
class="usa-footer-logo-img nih-logo"
|
|
src="/Structure/sparcle/uswds/resources/nih-logo-white.svg">
|
|
<span class="usa-sr-only">National Institutes of Health</span>
|
|
</a>
|
|
<a href="https://www.nlm.nih.gov/"><img alt="National Library of Medicine"
|
|
class="usa-footer-logo-img nlm-logo"
|
|
src="/Structure/sparcle/uswds/resources/nlm-logo-letters-white.svg">
|
|
<span class="usa-sr-only">National Library of Medicine</span>
|
|
</a>
|
|
<a href="https://www.usa.gov/"><img alt="USA.gov"
|
|
class="usa-footer-logo-img usagov-logo"
|
|
src="/Structure/sparcle/uswds/resources/usagov-logo-white.svg">
|
|
<span class="usa-sr-only">USA.gov</span></a>
|
|
</div>
|
|
</div>
|
|
<div class="usa-width-one-half">
|
|
<p class="about-links">
|
|
<a href="/home/about/">About NCBI</a>
|
|
<a href="/home/about/policies.shtml">Polices and Guidelines</a>
|
|
</p>
|
|
</div>
|
|
</div>
|
|
</div>
|
|
</footer>
|
|
</div>
|
|
|
|
<script src="/Structure/icn3d/lib/jquery-3.5.0.min.js"></script>
|
|
<script type="text/javascript">
|
|
$(document).ready(function () {
|
|
$(document).on("click", ".mmdb-expand", function (e) {
|
|
e.stopImmediatePropagation();
|
|
var oriId = $(this).attr('id');
|
|
var pos = oriId.lastIndexOf('_');
|
|
var id = oriId.substr(0, pos);
|
|
|
|
$("#" + id).show();
|
|
$("#" + id + "_expand").hide();
|
|
$("#" + id + "_shrink").show();
|
|
});
|
|
$(document).on("click", ".mmdb-shrink", function (e) {
|
|
e.stopImmediatePropagation();
|
|
var oriId = $(this).attr('id');
|
|
var pos = oriId.lastIndexOf('_');
|
|
var id = oriId.substr(0, pos);
|
|
$("#" + id).hide();
|
|
$("#" + id + "_expand").show();
|
|
$("#" + id + "_shrink").hide();
|
|
});
|
|
});
|
|
</script>
|
|
|
|
<script src="/Structure/shlu/jslibs/uswds/uswds.min.js"></script>
|
|
<script src="/Structure/shlu/jslibs/uswds/header.min.js"></script>
|
|
<script src="/Structure/shlu/jslibs/slucore.min.js"></script>
|
|
<script src="/Structure/shlu/jslibs/infobox/infobox.min.js"></script>
|
|
<script src="/Structure/shlu/jslibs/svg/svg.min.js"></script>
|
|
<script nonce='qRzoK/xtejHsZTMH3a2Hmw' type='text/javascript'>
|
|
function posObj(sheet, id, row, col, x, y) {
|
|
var rtl = false;
|
|
var sheetElement = document.getElementById(sheet);
|
|
if (!sheetElement) {
|
|
sheetElement = document.getElementById(sheet + '-grid-container');
|
|
}
|
|
if (sheetElement) {
|
|
rtl = sheetElement.getAttribute('dir') == 'rtl';
|
|
}
|
|
var r = document.getElementById(sheet + 'R' + row);
|
|
var c = document.getElementById(sheet + 'C' + col);
|
|
if (r && c) {
|
|
var objElement = document.getElementById(id);
|
|
var s = objElement.style;
|
|
var t = y;
|
|
while (r && r != sheetElement) {
|
|
t += r.offsetTop;
|
|
r = r.offsetParent;
|
|
}
|
|
var offsetX = x;
|
|
while (c && c != sheetElement) {
|
|
offsetX += c.offsetLeft;
|
|
c = c.offsetParent;
|
|
}
|
|
if (rtl) {
|
|
offsetX -= objElement.offsetWidth;
|
|
}
|
|
s.left = offsetX + 'px';
|
|
s.top = t + 'px';
|
|
s.display = 'block';
|
|
s.border = '1px solid #000000';
|
|
}
|
|
}
|
|
|
|
function posObjs() {
|
|
}
|
|
posObjs();
|
|
</script>
|
|
<script src="js/main.min.js"></script>
|
|
</body>
|
|
</html>
|