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<HTML><HEAD><TITLE>COG update</TITLE></HEAD>
<BODY>
<B><FONT size=+2>Recent changes to the names of Clusters of Orthologous Groups
<BR>of proteins (COGs) in the <A href="https://www.ncbi.nlm.nih.gov/COG/">COG database</A></FONT></B>
<P>
<P><FONT size=+1>If you can offer any corrections to the COG names, please do not hesitate to <A
href="mailto:galperin@ncbi.nlm.nih.gov;makarova@ncbi.nlm.nih.gov?subject=COG name change">send us a message</A></FONT>
</FONT>
<P>
<TABLE cellPadding=7 border=1>
<TBODY>
<TR>
<TD><B>COG No.</B></TD>
<TD><B>Fun.</B></TD>
<TD><B>Gene</B></TD>
<TD><B>Corrected name</B></TD>
<TD><B>Basis</B></TD>
<TD><B>Ref.</TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG0061.html">COG0061</A></TD>
<TD><CENTER>H</CENTER></TD>
<TD><I><CENTER>nadF</CENTER></I></TD>
<TD>NAD kinase</TD>
<TD>Experimental</TD>
<TD><a href="https://www.ncbinlm.nih.gov/pubmed/11488932">PubMed</TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG0109.html">COG0109</A></TD>
<TD><CENTER>H</CENTER></a></TD>
<TD><I><CENTER>ctaB</CENTER></I></TD>
<TD>Heme O synthase (polyprenyltransferase)</TD>
<TD>Experimental</TD>
<TD><A href="https://www.ncbinlm.nih.gov/pubmed/7968515,10675592,12206660,15491161">PubMed</A></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG0316.html">COG0316</A></TD>
<TD><CENTER>O</CENTER></TD>
<TD><I><CENTER>sufA</CENTER></I></TD>
<TD>Fe-S cluster assembly scaffold protein</TD>
<TD>Experimental</TD>
<TD><A href="https://www.ncbinlm.nih.gov/pubmed/12637501">PubMed</A></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG0396.html">COG0396</A></TD>
<TD><CENTER>O</CENTER></TD>
<TD><I><CENTER>sufC</CENTER></I></TD>
<TD>Cysteine desulfurase activator ATPase </TD>
<TD>Experimental</TD>
<TD><A href="https://www.ncbinlm.nih.gov/pubmed/12941942&amp;dopt=Abstract">PubMed</A></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG0406.html">COG0406</A></TD>
<TD><CENTER>R</CENTER></TD>
<TD><I><CENTER>phoE</CENTER></I></TD>
<TD>Broad specificity phosphatase PhoE and related phosphatases</TD>
<TD>Experimental</TD>
<TD><a href="https://www.ncbinlm.nih.gov/pubmed/11514674,11827481&dopt=Summary">PubMed</TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG0455.html">COG0455</A></TD>
<TD><CENTER>N</CENTER></TD>
<TD><I><CENTER>flhG</CENTER></I></TD>
<TD>Antiactivator of flagellar biosynthesis FleN, an ATPase</TD>
<TD>Experimental</TD>
<TD><a href="https://www.ncbinlm.nih.gov/pubmed/11673434,14617143">PubMed</TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG0510.html">COG0510</A></TD>
<TD><CENTER>H</CENTER></TD>
<TD><I><CENTER>ycfN</CENTER></I></TD>
<TD>Thiamine kinase and related kinases (needs to be split!)</TD>
<TD>Experimental</TD>
<TD><a href="https://www.ncbinlm.nih.gov/pubmed/15150256">PubMed</TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG0520.html">COG0520</A></TD>
<TD><CENTER>O</CENTER></TD>
<TD><I><CENTER>csdA</CENTER></I></TD>
<TD>Selenocysteine lyase/Cysteine desulfurase</TD>
<TD>Experimental</TD>
<TD><a href="https://www.ncbinlm.nih.gov/pubmed/9278392,10739946,15901727">PubMed</TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG0533.html">COG0533</A></TD>
<TD><CENTER>L</CENTER></TD>
<TD><I><CENTER>Kae1</CENTER></I></TD>
<TD>ATP-binding apurinic endonuclease </TD>
<TD>Experimental</TD>
<TD><a href="https://www.ncbinlm.nih.gov/pubmed/1885539,1729196,16617437,17766251">PubMed</TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG0542.html">COG0542</A></TD>
<TD><CENTER>O</CENTER></TD>
<TD><I><CENTER>clpA</CENTER></I></TD>
<TD>ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones (should be split into ClpA and ClpB families!)</TD>
<TD>Experimental</TD>
<TD><a href="https://www.ncbinlm.nih.gov/pubmed/2186030,7991609,10952988,12205096,15657062">PubMed</TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG0618.html">COG0618</A></TD>
<TD><CENTER>F</CENTER></TD>
<TD><I><CENTER>ytqI</CENTER></I></TD>
<TD>oligoRNAse and pAp phosphatase</TD>
<TD>Experimental</TD>
<TD><a href="https://www.ncbinlm.nih.gov/pubmed/17586819">PubMed</a></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG0628.html">COG0628</A></TD>
<TD><CENTER>R</CENTER></TD>
<TD><I><CENTER>yhhT</CENTER></I></TD>
<TD>Predicted permease, member of the PurR regulon</TD>
<TD>Prediction, promoter-based</TD>
<TD><a href="https://www.ncbinlm.nih.gov/pubmed/12391881">PubMed</a></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG0719.html">COG0719</A></TD>
<TD><CENTER>O</CENTER></TD>
<TD><I><CENTER>sufB</CENTER></I></TD>
<TD>Cysteine desulfurase activator SufB</TD>
<TD>Experimental</TD>
<TD><A href="https://www.ncbinlm.nih.gov/pubmed/12941942">PubMed</A></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG0761.html">COG0761</A></TD>
<TD><CENTER>I</CENTER></TD>
<TD><I><CENTER>lytB</CENTER></I></TD>
<TD>4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH</TD>
<TD>Experimental</TD>
<TD><A href="https://www.ncbinlm.nih.gov/pubmed/11004185,11818558,12198182,12482608">PubMed</A></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG0821.html">COG0821</A></TD>
<TD><CENTER>I</CENTER></TD>
<TD><I><CENTER>gcpE</CENTER></I></TD>
<TD>1-hydroxy-2-methyl-2-(e)-butenyl 4-diphosphate synthase</TD>
<TD>Experimental</TD>
<TD><A href="https://www.ncbinlm.nih.gov/pubmed/11163766,11274098,11752431,12482607">PubMed</A></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG0849.html">COG0849</A></TD>
<TD><CENTER>D</CENTER></TD>
<TD><I><CENTER>ftsA</CENTER></I></TD>
<TD>Cell division ATPase FtsA</TD>
<TD>Experimental</TD>
<TD><A href="https://www.ncbinlm.nih.gov/pubmed/11298280,11032797">PubMed</A></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG1304.html">COG1304</A></TD>
<TD><CENTER>H</CENTER></a></TD>
<TD><I><CENTER>idi</CENTER></I></TD>
<TD>Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins)</TD>
<TD>Experimental</TD>
<TD><A href="https://www.ncbinlm.nih.gov/pubmed/11158573,
12798687,14745175,14996812,15009187&amp;dopt=Abstract">PubMed</A></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG1354.html">COG1354</A></TD>
<TD><CENTER>L</CENTER></a></TD>
<TD><I><CENTER>scpA</CENTER></I></TD>
<TD>Chromosome segregation and condensation protein A </TD>
<TD>Experimental</TD>
<TD><A href="https://www.ncbinlm.nih.gov/pubmed/12100548">PubMed</A></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG1356.html">COG1356</A></TD>
<TD><CENTER>R</CENTER></a></TD>
<TD><I><CENTER>tfx</CENTER></I></TD>
<TD>Transcriptional regulator</TD>
<TD>Experimental</TD>
<TD><A href="https://www.ncbinlm.nih.gov/pubmed/10027980">PubMed</A></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG1386.html">COG1386</A></TD>
<TD><CENTER>L</CENTER></a></TD>
<TD><I><CENTER>scpB</CENTER></I></TD>
<TD>Chromosome segregation and condensation protein B </TD>
<TD>Experimental</TD>
<TD><A href="https://www.ncbinlm.nih.gov/pubmed/12100548">PubMed</A></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG1469.html">COG1469</A></TD>
<TD><CENTER>H</CENTER></a></TD>
<TD><I><CENTER>folE2</CENTER></I></TD>
<TD>GTP cyclohydrolase IB</TD>
<TD>Experimental</TD>
<TD><A href="https://www.ncbinlm.nih.gov/pubmed/17032654&amp;dopt=Abstract">PubMed</A></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG1496.html">COG1496</A></TD>
<TD><CENTER>Q</CENTER></a></TD>
<TD><I><CENTER>yfiH</CENTER></I></TD>
<TD>Multicopper polyphenol oxidase (laccase)</TD>
<TD>Experimental</TD>
<TD><A href="https://www.ncbinlm.nih.gov/pubmed/16740638&amp;dopt=Abstract">PubMed</A></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG1612.html">COG1612</A></TD>
<TD><CENTER>H</CENTER></a></TD>
<TD><I><CENTER>ctaA</CENTER></I></TD>
<TD>Heme A synthase (monooxygenase)</TD>
<TD>Experimental</TD>
<TD><A href="https://www.ncbinlm.nih.gov/pubmed/2549006,7968515,12206660,16321940,16989823">PubMed</A></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG1738.html">COG1738</A></TD>
<TD><CENTER>R</CENTER></TD>
<TD><I><CENTER>yhhQ</CENTER></I></TD>
<TD>Uncharacterized member of the PurR regulon</TD>
<TD>Prediction, promoter-based</TD>
<TD><a href="https://www.ncbinlm.nih.gov/pubmed/12391881">PubMed</a></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG1764.html">COG1764</A></TD>
<TD><CENTER>Q</CENTER></TD>
<TD><I><CENTER>osmC</CENTER></I></TD>
<TD>Organic hydroperoxide reductase</TD>
<TD>Experimental</TD>
<TD><a href="https://www.ncbinlm.nih.gov/pubmed/14627744">PubMed</a></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG1766.html">COG1766</A></TD>
<TD><CENTER>N</CENTER></TD>
<TD><I><CENTER>fliF</CENTER></I></TD>
<TD>Flagellar basal body M-ring protein</TD>
<TD>Experimental</TD>
<TD><a href="https://www.ncbinlm.nih.gov/pubmed/1404383,8107139,12591880">PubMed</a></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG1776.html">COG1776</A></TD>
<TD><CENTER>N</CENTER></TD>
<TD><I><CENTER>cheC</CENTER></I></TD>
<TD>Chemotaxis protein phosphatase CheC</TD>
<TD>Experimental</TD>
<TD><a href="https://www.ncbinlm.nih.gov/pubmed/14749334,17609139,15546616,17675386">PubMed</a></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG1865.html">COG1865</A></TD>
<TD><CENTER>H</CENTER></TD>
<TD><I><CENTER>cbiZ</CENTER></I></TD>
<TD>Adenosylcobinamide amidohydrolase</TD>
<TD>Experimental</TD>
<TD><a href="https://www.ncbinlm.nih.gov/pubmed/14990804">PubMed</a></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG1956.html">COG1956</A></TD>
<TD><CENTER>E</CENTER></TD>
<TD><I><CENTER>msrC</CENTER></I></TD>
<TD>Methionine-(R)-sulfoxide reductase</TD>
<TD>Experimental</TD>
<TD><a href="https://www.ncbinlm.nih.gov/pubmed/17535911">PubMed</a></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG1968.html">COG1968</A></TD>
<TD><CENTER>M</CENTER></TD>
<TD><I><CENTER>bacA</CENTER></I></TD>
<TD>Undecaprenyl pyrophosphate phosphatase</TD>
<TD>Experimental</TD>
<TD><a href="https://www.ncbinlm.nih.gov/pubmed/15138271">PubMed</a></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG1990.html">COG1990</A></TD>
<TD><CENTER>J</CENTER></TD>
<TD><I><CENTER>pth2</CENTER></I></TD>
<TD>Peptidyl-tRNA hydrolase</TD>
<TD>Experimental</TD>
<TD><A href="https://www.ncbinlm.nih.gov/pubmed/12475929">PubMed</A></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG2166.html">COG2166</A></TD>
<TD><CENTER>O</CENTER></TD>
<TD><I><CENTER>sufE</CENTER></I></TD>
<TD>Cysteine desulfurase SufE subunit</TD>
<TD>Experimental</TD>
<TD><A href="https://www.ncbinlm.nih.gov/pubmed/12941942">PubMed</A></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG2329.html">COG2329</A></TD>
<TD><CENTER>F</CENTER></TD>
<TD><I><CENTER>isdG</CENTER></I></TD>
<TD>Heme-degrading monooxygenase</TD>
<TD>Experimental</TD>
<TD><A href="https://www.ncbinlm.nih.gov/pubmed/12574635,14570922,15520015,16428411">PubMed</A></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG2339.html">COG2339</A></TD>
<TD><CENTER>O</CENTER></TD>
<TD><I><CENTER>prsW</CENTER></I></TD>
<TD>Membrane proteinase, regulator of anti-sigma factor</TD>
<TD>Experimental</TD>
<TD><A href="https://www.ncbinlm.nih.gov/pubmed/16816000">PubMed</A></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG2357.html">COG2357</A></TD>
<TD><CENTER>T</CENTER></TD>
<TD><I><CENTER>ywaC</CENTER></I></TD>
<TD>(p)ppGpp synthetase</TD>
<TD>Experimental</TD>
<TD><A href="https://www.ncbinlm.nih.gov/pubmed/18067544">PubMed</A></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG2913.html">COG2913</A></TD>
<TD><CENTER>M</CENTER></TD>
<TD><I><CENTER>smpA</CENTER></I></TD>
<TD>Outer membrane lipoprotein OmlA <BR>(small protein A)</TD>
<TD>Experimental</TD>
<TD><A href="https://www.ncbinlm.nih.gov/pubmed/9973334,12900013&amp;dopt=Abstract">PubMed</A></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG3023.html">COG3023</A></TD>
<TD><CENTER>M</CENTER></TD>
<TD><I><CENTER>ampD</CENTER></I></TD>
<TD>N-acetyl-anhydromuramyl-L-alanine amidase</TD>
<TD>Experimental</TD>
<TD><a href="https://www.ncbinlm.nih.gov/pubmed/14507260,12654266">PubMed</a></TD></TR>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG3253.html">COG3253</A></TD>
<TD><CENTER>S</CENTER></TD>
<TD><I><CENTER>ywfI</CENTER></I></TD>
<TD>Uncharacterized protein involved in anaerobic stress response</TD>
<TD>Proteomics</TD>
<TD><A href="https://www.ncbinlm.nih.gov/pubmed/10658656">PubMed</A></TD>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG4932.html">COG4932</A></TD>
<TD><CENTER>N</CENTER></TD>
<TD><I><CENTER>bcpA</CENTER></I></TD>
<TD>Pilin</TD>
<TD>Experimental</TD>
<TD><A href="https://www.ncbinlm.nih.gov/pubmed/17897374">PubMed</A></TD>
<TR>
<TD><A href="ftp://ftp.ncbi.nih.gov/pub/COG/COG2014/static/byCOG/COG5006.html">COG5006</A></TD>
<TD><CENTER>E</CENTER></TD>
<TD><I><CENTER>rhtA</CENTER></I></TD>
<TD>Threonine/homoserine efflux transporter</TD>
<TD>Experimental</TD>
<TD><A href="https://www.ncbinlm.nih.gov/pubmed/12648727">PubMed</A></TD></TR>
</TBODY></TABLE>
<P>Last updated Nov. 15, 2007 </P></UL></BODY></HTML>
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