2719 lines
154 KiB
HTML
2719 lines
154 KiB
HTML
<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN">
|
||
<HTML><HEAD><TITLE>Analogous Enzymes 2010 update</TITLE>
|
||
<meta http-equiv="Content-Type" content="text/html; charset=windows-1252">
|
||
<BODY vLink=#800080 link=#0000ff><B><FONT size=+1>Table S1. An update to the 1998 listing of analogous enzymes</B></FONT>.
|
||
<P>This listing was originally prepared as a web supplement to the article by M.Y. Galperin, D.R. Walker and E.V. Koonin
|
||
<BR><B>"<A href="https://www.ncbi.nlm.nih.gov/pubmed/9724324">Analogous enzymes: Independent inventions in enzyme evolution</A>"</B>,
|
||
published in 1998 in <I>Genome Research</I> <B>8:</B>779-790.
|
||
<BR><A href="https://www.ncbi.nlm.nih.gov/pubmed/9724324">Abstract</A>.
|
||
<A href="http://www.genome.org/cgi/content/full/8/8/779">Full text (HTML)</A>.
|
||
<A href="http://genome.cshlp.org/content/8/8/779.full.pdf+html">Full text (PDF)</A>.
|
||
|
||
<P>The current file is the Supplementary Table S1 to the article
|
||
by M.V. Omelchenko, M.Y. Galperin, Y.I. Wolf and E.V. Koonin <BR><B>"<A href="https://www.ncbi.nlm.nih.gov/pubmed/20433725">Non-homologous isofunctional enzymes: A systematic analysis of alternative solutions in enzyme evolution</B></A>",
|
||
<BR>published in <I>Biology Direct</I> 2010, <B>5</B>:31.
|
||
<A href="https://www.ncbi.nlm.nih.gov/pubmed/20433725">Abstract</A>.
|
||
<A href="http://www.biology-direct.com/content/5/1/31/">Full text (HTML)</A>.
|
||
<A href="http://www.biology-direct.com/content/pdf/1745-6150-5-31.pdf">Full text (PDF)</A>.
|
||
<P>This updated version lists the same 105 EC nodes as the original one. However, enzyme pairs that could not be confirmed
|
||
<BR>as analogous (either proved to be homologous or to have mis-assigned functions) are indicated by yellow shading.
|
||
|
||
<P>
|
||
<TABLE borderColor=#808080 cellSpacing=2 cellPadding=7 border=1>
|
||
<TBODY>
|
||
<TR>
|
||
<TD vAlign=top width="1%"><FONT size=+1><B>No.</B></FONT></TD>
|
||
<TD vAlign=top width="2%"><FONT size=+1><B>EC no.</B></CENTER></FONT></TD>
|
||
<TD vAlign=top width="20%"><FONT size=+1><B>Enzyme name</B></FONT></TD>
|
||
<TD vAlign=top width="5%"><FONT size=+1><B>Example</B></FONT></FONT></TD>
|
||
<TD vAlign=top width="2%"><FONT size=+1><B>PDB</B></FONT></TD>
|
||
<TD vAlign=top width="10%"><FONT size=+1><B>SCOP fold</B></FONT></TD>
|
||
<TD vAlign=top width="10%"><FONT size=+1><B>Family (Pfam)</B></FONT></TD>
|
||
<TD vAlign=top width="5%"><FONT size=+1><B>Ref.</B></FONT></TD>
|
||
<TD vAlign=top width="20%"><FONT size=+1><B>Comments</B></FONT></TD></TR>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=3>1</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.1.1.1"><B>1.1.1.1</B></A></td>
|
||
<td>Alcohol dehydrogenase (NAD+)</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P00325">ADH1B_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1HDY"><B>1HDY</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1HDY">GroES-like & Rossmann-fold</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF00107">Zinc-contaning alcohol dehydrogenase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/9802210,8201622"><B>9802210, 8201622</B></A></td>
|
||
<td center rowspan=3>Three distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.1.1.1"><B>1.1.1.1</B></A></td>
|
||
<td>Alcohol dehydrogenase (NAD+)</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P10127">ADH4_YEAST</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2BI4"><B>2BI4</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2BI4">Dehydroquinate synthase-like</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF00465">Iron-contaning alcohol dehydrogenase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/3282541,2823079"><B>3282541, 2823079</B></A></td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.1.1.1"><B>1.1.1.1</B></A></td>
|
||
<td>Alcohol dehydrogenase (NAD+)</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P00334">ADH_DROME</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1MG5"><B>1MG5</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1MG5">Rossmann-fold</A></td>
|
||
<td><A href="http://pfam.xfam.org/family/PF00106">Short chain dehydrogenase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/15016358,11669613"><B>15016358, 11669613</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=3>2</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.1.1.2"><B>1.1.1.2</B></A></td>
|
||
<td>Alcohol dehydrogenase (NADP+)</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P0A4X1">ADHC_MYCBO</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1YQD"><B>1YQD</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1YQD">GroES-like & Rossmann-fold</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF00107">Zinc-contaning alcohol dehydrogenase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1427101,15829607"><B>1427101, 15829607</B></A></td>
|
||
<td center rowspan=3>Three distinct structural folds</td></tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.1.1.2"><B>1.1.1.2</B></A></td>
|
||
<td>Alcohol dehydrogenase (NADP+)</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P14550">AK1A1_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2ALR"><B>2ALR</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2ALR">TIM beta/alpha-barrel</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF00248">Aldo/keto reductase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/15299353,10486210"><B>15299353, 10486210</B></A></td></tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.1.1.2"><B>1.1.1.2</B></A></td>
|
||
<td>Alcohol dehydrogenase (NADP+)</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q09669">ADH4_SCHPO</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1O2D"><B>1O2D</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1O2D">Dehydroquinate synthase-like</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF00465">Iron-contaning alcohol dehydrogenase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/15327949,14705036"><B>15327949, 14705036</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>3</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.1.1.27"><B>1.1.1.27</B></A></td>
|
||
<td>L-lactate dehydrogenase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P00338">LDHA_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1EZ4"><B>1EZ4</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1EZ4">Rossmann-fold & LDH C-terminal domain</A></td>
|
||
<td center>Lactate & malate dehydrogenases</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/11807949"><B>PubMed</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td></tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.1.1.27"><B>1.1.1.27</B></A></td>
|
||
<td>L-lactate dehydrogenase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q07251">LDH_RALEH</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1VBI"><B>1VBI</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1rfm">L-sulfolactate dehydrogenase-like</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF02615">Malate/L-Lactate dehydrogenases</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8405966"><B>8405966</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>4</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.1.1.28"><B>1.1.1.28</B></A></td>
|
||
<td>D-lactate dehydrogenase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P52643">LDHD_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2DLD"><B>2DLD</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2DLD">Rossmann-fold & Flavodoxin-like</A></td>
|
||
<td center>Formate/glycerate dehydrogenases</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/9025293"><B>9025293</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td></tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.1.1.28"><B>1.1.1.28</B></A></td>
|
||
<td>D-lactate dehydrogenase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P06149">DLD_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1F0X"><B>1F0X</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1F0X">FAD-binding domain & Ferredoxin-like</A></td>
|
||
<td center>D-lactate dehydrogenase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/10944213"><B>10944213</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>5</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.1.1.37"><B>1.1.1.37</B></A></td>
|
||
<td>Malate dehydrogenase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q07841">MDH_HALMA</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2J5K"><B>2J5K</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2J5K">Rossmann-fold & LDH C-terminal domain</A></td>
|
||
<td center>L-lactate/malate dehydrogenases</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8476859,10653643"><B>8476859, 10653643</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td></tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.1.1.37"><B>1.1.1.37</B></A></td>
|
||
<td>Malate dehydrogenase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P16142">MDH_METFE</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2G8Y"><B>2G8Y</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1rfm">L-sulfolactate dehydrogenase-like</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF02615">Malate/L-Lactate dehydrogenases</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2110059,10850983"><B>2110059, 10850983</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center rowspan=2>6</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.1.1.42"><B>1.1.1.42</B></A></td>
|
||
<td>Isocitrate dehydrogenase (NADP+)</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P08200">IDH_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1IDC"><B>1IDC</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1IDC">Isocitrate/Isopropylmalate dehydrogenase-like</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF00180">Isocitrate/isopropylmalate dehydrogenase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1888729"><B>1888729</B></A></td>
|
||
<td rowspan=2>Same fold, same superfamily, RMSD=4.0 Å</td></tr>
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.1.1.42"><B>1.1.1.42</B></A></td>
|
||
<td>Isocitrate dehydrogenase (NADP+)</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P16100">IDH_AZOVI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1ITW"><B>1ITW</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1ITW">Isocitrate/Isopropylmalate dehydrogenase-like</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF03971">Monomeric isocitrate dehydrogenase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/4149369"><B>4149369</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>7</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.1.1.47"><B>1.1.1.47</B></A></td>
|
||
<td>Glucose 1-dehydrogenase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P12310">DHG_BACSU</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1GCO"><B>1GCO</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1GCO">Rossmann-fold</A></td>
|
||
<td><A href="http://pfam.xfam.org/family/PF00106">Short chain dehydrogenase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/3082854"><B>3082854</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td></tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.1.1.47"><B>1.1.1.47</B></A></td>
|
||
<td>Glucose 1-dehydrogenase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P13203">DHG_THEAC</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1HDZ"><B>1HDZ</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1HDZ">GroES-like</A></td>
|
||
<td><A href="http://pfam.xfam.org/family/PF08240">Alcohol dehydrogenase GroES-like domain</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2803257,8436115"><B>2803257, 8436115</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>8</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.1.1.50"><B>1.1.1.50</B></A></td>
|
||
<td>3alpha-hydroxysteroid dehydrogenase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q9ZFY9">Q9ZFY9_COMTE</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1FJH"><B>1FJH</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1FJH">Rossmann-fold</A></td>
|
||
<td><A href="http://pfam.xfam.org/family/PF00106">Short chain dehydrogenase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/10833462"><B>10833462</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td></tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.1.1.50"><B>1.1.1.50</B></A></td>
|
||
<td>3alpha-hydroxysteroid dehydrogenase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P17516">AK1C4_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2FVL"><B>2FVL</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2FVL">TIM beta/alpha barrel</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF00248">Aldo/keto reductase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1530633,11158055"><B>1530633, 11158055</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>9</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.1.1.62"><B>1.1.1.62</B></A></td>
|
||
<td>Estradiol 17<31>-dehydrogenase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P14061">DHB1_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1FDS"><B>1FDS</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1FDS">Rossmann-fold</A></td>
|
||
<td><A href="http://pfam.xfam.org/family/PF00106">Short chain dehydrogenase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2846351,7663947"><B>2846351, 7663947</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td></tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.1.1.62"><B>1.1.1.62</B></A></td>
|
||
<td>Estradiol 17<31>-dehydrogenase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P70694">DHB5_MOUSE</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1Q5M"><B>1Q5M</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1Q5M">TIM beta/alpha barrel</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF00248">Aldo/keto reductase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/7737980"><B>PubMed</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>10</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.2.1.2"><B>1.2.1.2</B></A></td>
|
||
<td>Formate dehydrogenase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P07658">FDHF_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1KQF"><B>1FDI</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1FDI">Formate dehydrogenase/ DMSO reductase</A></td>
|
||
<td center>Molybdopterin-containing oxidoreductases</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/9036855"><B>9036855</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td></tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.2.1.2"><B>1.2.1.2</B></A></td>
|
||
<td>Formate dehydrogenase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P33160">FDH_PSESR</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2NAC"><B>2NAC</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2NAC">Rossmann-fold & Flavodoxin-like</A></td>
|
||
<td center>2-hydroxyacid dehydrogenases</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1597184,8484798"><B>1597184, 8484798</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>11</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.2.99.2"><B>1.2.99.2</B></A></td>
|
||
<td>Carbon-monoxide dehydrogenase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P19919">DCML_OLICO</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1N60"><B>1N60</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1N60">CO dehydrogenase ISP C-domain like and others</A></td>
|
||
<td> </td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/10482497,12475995"><B>10482497, 12475995</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td></tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.2.99.2"><B>1.2.99.2</B></A></td>
|
||
<td>Carbon-monoxide dehydrogenase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P31896">COOS_RHORU</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1JQK"><B>1JQK</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1JQK">Prismane protein-like</A></td>
|
||
<td center>Prismane/CO dehydrogenase family</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8561463,11593006"><B>8561463, 11593006</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center rowspan=2>12</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.3.1.33"><B>1.3.1.33</B></A></td>
|
||
<td>Protochlorophyllide reductase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P26164">BCHN_RHOCA</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=3MIN"><B>3MIN</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=3MIN">Nitrogenase Fe-Mo fold</A></td>
|
||
<td><A href="http://www.ebi.ac.uk/interpro/IEntry?ac=IPR005970">Protochlorophyllide reductase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/10811655"><B>10811655</B></A></td>
|
||
<td rowspan=2>The two forms use different electron donors</td>
|
||
</tr>
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.3.1.33"><B>1.3.1.33</B></A></td>
|
||
<td>Protochlorophyllide reductase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P21218">PORB_ARATH</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1hdu"><i>1hdu</i></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1hdu">Rossmann-fold</A></td>
|
||
<td><A href="http://pfam.xfam.org/family/PF00106">Short chain dehydrogenase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/7659751"><B>7659751</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>13</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.5.1.3"><B>1.5.1.3</B></A></td>
|
||
<td>Dihydrofolate reductase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P11045">DYR_BACSU</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1MVS"><B>1MVS</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1MVS">Dihydrofolate reductase-like</A></td>
|
||
<td center>Dihydrofolate reductases</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1731871"><B>1731871</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.5.1.3"><B>1.5.1.3</B></A></td>
|
||
<td>Dihydrofolate reductase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P0AFS3">FOLM_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=3edm"><I>3edm</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=3edm">Rossmann-fold</A></td>
|
||
<td><A href="http://pfam.xfam.org/family/PF00106">Short chain dehydrogenase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/14617668"><B>14617668</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>14</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.6.99.3"><B>1.6.99.3</B></A></td>
|
||
<td>NADH dehydrogenase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P26829">DHNA_BACYN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1XHC"><B>1XHC</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1XHC">FAD/NAD(P)-binding domain</A></td>
|
||
<td>NADH dehydrogenase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1917890"><B>1917890</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.6.99.3"><B>1.6.99.3</B></A></td>
|
||
<td>NADH dehydrogenase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P28331">NDUS1_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2FUG"><B>2FUG</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=NQO3">Formate dehydrogenase/ DMSO reductase</A></td>
|
||
<td center>Complex I 75 kDa subunit family</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1935949"><B>1935949</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center rowspan=2>15</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.10.3.1"><B>1.10.3.1</B></A></td>
|
||
<td>Catechol oxidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P25161">DXA2_DROME</A></td>
|
||
<td>N/A</td>
|
||
<td colspan=2>Corrected to <A href="http://www.uniprot.org/uniprot/P25161">PSMD3_DROME</A>, 26S proteasome regulatory subunit 3</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1909680"><B>1909680</B></A></td>
|
||
<td rowspan=2>Misassignment corrected</td>
|
||
</tr>
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.10.3.1"><B>1.10.3.1</B></A></td>
|
||
<td>Diphenol oxidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P43310">PPO_SPIOL</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1BT1"><B>1BT1</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1BT1">Di-copper centre-containing domain</A></td>
|
||
<td> </td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/7794929"><B>7794929</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>16</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.11.1.5"><B>1.11.1.5</B></A></td>
|
||
<td>Cytochrome-c peroxidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P14532">CCPR_PSEAE</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1EB7"><B>1EB7</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1IQC">Cytochrome c</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF03150">Di-heme cytochrome c peroxidase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/7781769,1657179,8591033"><B>7781769, 1657179, 8591033</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.11.1.5"><B>1.11.1.5</B></A></td>
|
||
<td>Cytochrome-c peroxidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P00431">CCPR_YEAST</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1EBE"><B>1EBE</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1EBE">Heme-dependent peroxidases</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF00141">Peroxidase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2169873,6092361"><B>2169873, 6092361</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=3>17</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.11.1.6"><B>1.11.1.6</B></A></td>
|
||
<td>Catalase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P04040">CATA_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1QQW"><B>1QQW</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1QQW">Heme-dependent catalase</A></td>
|
||
<td>Heme-dependent catalase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/10666617,3755525"><B>10666617, 3755525</B></A></td>
|
||
<td rowspan=3>Three distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.11.1.6"><B>1.11.1.6</B></A></td>
|
||
<td>Catalase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P13029">CATA_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2FXG"><B>2FXG</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2FXG">Heme-dependent peroxidases</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF00141">Peroxidase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/374409,2670897,8508796"><B>374409, 2670897, 8508796</B></A></td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.11.1.6"><B>1.11.1.6</B></A></td>
|
||
<td>Catalase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P60355">MCAT_LACPL</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1JKU"><B>1JKU</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1JKU">Ferritin-like</A></td>
|
||
<td center>Manganese catalase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8939876"><B>8939876</B></A></td>
|
||
</tr>
|
||
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=3>18</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.11.1.7"><B>1.11.1.7</B></A></td>
|
||
<td>Peroxidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/O08709">PRDX6_MOUSE</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1PRX"><B>1PRX</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1PRX">Thioredoxin</A></td>
|
||
<td>Thioredoxin</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/9291135,10395907,9587003"><B>9291135, 10395907, 9587003</B></A></td>
|
||
<td rowspan=3>Three distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.11.1.7"><B>1.11.1.7</B></A></td>
|
||
<td>Peroxidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P05164">PERM_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1MYP"><B>1MYP</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1MYP">Heme-dependent peroxidases</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF03098">Animal heme peroxidase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2154223"><B>2154223</B></A></td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.11.1.7"><B>1.11.1.7</B></A></td>
|
||
<td>Peroxidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P31545">YCDB_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2D3Q"><I>2D3Q</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2D3Q">Ferredoxin-like</A></td>
|
||
<td center>Dyp-type peroxidase-like</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/16551627,14684913"><B>16551627, 14684913</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=3>19</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.11.1.10"><B>1.11.1.10</B></A></td>
|
||
<td>Chloride peroxidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P25026">PRXC_PSEPY</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1A88"><B>1A88</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1A88">Alpha/beta-hydrolases</A></td>
|
||
<td center>Haloperoxidase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8344520"><B>8344520</B></A></td>
|
||
<td rowspan=3>Three distinct structural folds</td></tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.11.1.10"><B>1.11.1.10</B></A></td>
|
||
<td>Chloride peroxidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P49053">PRXC_CURIN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1VNC"><B>1VNC</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1VNC">Acid phosphatase</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF01569">Type 2 phosphatidic acid phosphatase (PAP2)</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/9165086"><B>9165086</B></A></td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.11.1.10"><B>1.11.1.10</B></A></td>
|
||
<td>Chloride peroxidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P04963">PRXC_CALFU</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2CPO"><B>2CPO</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2CPO">EF Hand-like</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF01328">Cloroperoxidase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8747463,11278701"><B>8747463, 11278701</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>20</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.14.15.3"><B>1.14.15.3</B></A></td>
|
||
<td>Alkane 1-monooxygenase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P12691">ALKB_PSEOL</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1AFR"><I>1AFR</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1AFR"><I>Ferritin-like (predicted)</I></A></td>
|
||
<td center><A href="http://pfam.xfam.org/family?PF00487">Fatty acid desaturase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2647718"><B>2647718</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.14.15.3"><B>1.14.15.3</B></A></td>
|
||
<td>Alkane 1-monooxygenase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q5TCH4">CP4AM_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1TQN"><B>1TQN</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1TQN">Cytochrome P450</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF00067">Cytochrome P450</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/14641109,7798189,11931657,2361958"><B>PubMed</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=3>21</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.15.1.1"><B>1.15.1.1</B></A></td>
|
||
<td>Superoxide dismutase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P09157">SODF_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1ISA"><B>1ISA</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1ISA">Fe,Mn superoxide dismutase</A></td>
|
||
<td center>Fe,Mn superoxide dismutase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2447093"><B>2447093</B></A></td>
|
||
<td rowspan=3>Three distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.15.1.1"><B>1.15.1.1</B></A></td>
|
||
<td>Superoxide dismutase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P53635">SODC_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1ESO"><B>1ESO</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1ESO">Immunoglobulin-like beta-sandwich</A></td>
|
||
<td center>Cu,Zn superoxide dismutase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/9405149"><B>9405149</B></A></td>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.15.1.1"><B>1.15.1.1</B></A></td>
|
||
<td>Superoxide dismutase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P80734">SODN_STRSO</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1Q0D"><B>1Q0D</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1Q0D">Four-helical up-and-down bundle</A></td>
|
||
<td center>Nickel-containing superoxide dismutase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8836134,15173586"><B>8836134, 15173586</B></A></td>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center rowspan=2>22</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.17.4.2"><B>1.17.4.2</B></A></td>
|
||
<td>Ribonucleoside-triphosphate reductase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P28903">NRDD_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1H7A"><B>1H7A</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1H7A">PFL-like glycyl radical enzymes</A></td>
|
||
<td center>Anaerobic ribonucleotide reductase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/7852304,12655046"><B>7852304, 12655046</B></A></td>
|
||
<td rowspan=2>Same fold, same superfamily, RMSD=3.3 Å</td></tr>
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.17.4.2"><B>1.17.4.2</B></A></td>
|
||
<td>Ribonucleoside-triphosphate reductase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q59490">RTPR_LACLE</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1L1L"><B>1L1L</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1L1L">PFL-like glycyl radical enzymes</A></td>
|
||
<td center>B12-dependent (class II) ribonucleotide reductase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/11875520"><B>11875520</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>23</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.12.2.1"><B>1.18.99.1</B></A></td>
|
||
<td>Hydrogenase <BR>(now <A href="http://enzyme.expasy.org/EC/1.12.2.1"><B>EC 1.12.2.1</B></A>)</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P12944">PHNL_DESGI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1FRV"><B>1FRV</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1FRV">HydA/Nqo6-like & HydB/Nqo4-like</A></td>
|
||
<td center>Ni-Fe hydrogenase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2651421,7854413"><B>2651421, 7854413</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/1.12.7.2"><B>1.18.99.1</B></A></td>
|
||
<td>Hydrogenase <BR>(now <A href="http://enzyme.expasy.org/EC/1.12.7.2"><B>EC 1.12.7.2</B></A>)</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P29166">PHF1_CLOPA</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1FEH"><B>1FEH</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1FEH">Fe-only hydrogenase</A></td>
|
||
<td center>Iron-only hydrogenase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1911757,9836629"><B>1911757, 9836629</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>24</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.1.1.17"><B>2.1.1.17</B></A></td>
|
||
<td>Phosphatidylethanolamine N-methyltransferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q05197">PMTA_RHOSH</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=3DH0"><I>3DH0</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=3DH0">SAM-dependent methyltransferases</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF08241">SAM-dependent methyltransferase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8340421"><B>8340421</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.1.1.17"><B>2.1.1.17</B></A></td>
|
||
<td>Phosphatidylethanolamine N-methyltransferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P05374">PEM1_YEAST</A></td>
|
||
<td>N/A</td>
|
||
<td>Integral membrane protein</td>
|
||
<td> </td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2445736"><B>2445736</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center rowspan=2>25</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.3.1.15"><B>2.3.1.15</B></A></td>
|
||
<td>Glycerol-3-phosphate O-acyltransferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P0A7A7">PLSB_ECOLI</A></td>
|
||
<td>N/A</td>
|
||
<td> </td>
|
||
<td><A href="http://pfam.xfam.org/family/PF01553">Acyltransferase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/6350296"><B>6350296</B></A></td>
|
||
<td rowspan=2>Same catalytic domain</td></tr>
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.3.1.15"><B>2.3.1.15</B></A></td>
|
||
<td>Glycerol-3-phosphate O-acyltransferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P10349">PLSB_CUCMO</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1K30"><B>1K30</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1K30">Glycerol-3-phosphate 1-acyltransferase</A></td>
|
||
<td center>Glycerol-3-phosphate 1-acyltransferase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/11377195"><B>11377195</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>26</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.3.1.28"><B>2.3.1.28</B></A></td>
|
||
<td>Chloramphenicol O-acetyltransferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P23364">CAT4_AGRTU</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1XAT"><B>1XAT</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1XAT">Single-stranded left-handed beta-helix</A></td>
|
||
<td center>Galactoside acetyltransferase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2013403,9578552"><B>2013403, 9578552</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.3.1.28"><B>2.3.1.28</B></A></td>
|
||
<td>Chloramphenicol O-acetyltransferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P00484">CAT3_ECOLX</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=3CLA"><B>3CLA</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=3CLA">CoA-dependent acyltransferases</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF00302">Chloramphenicol acetyltransferase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2187098"><B>2187098</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>27</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.3.1.43"><B>2.3.1.43</B></A></td>
|
||
<td>Phosphatidylcholine-sterol O-acyltransferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P04180">LCAT_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1ex9"><I>1ex9</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1ex9"><I>Alpha/beta hydrolase fold (predicted)</I></A></td>
|
||
<td> </td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2823898"><B>2823898</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.3.1.43"><B>2.3.1.43</B></A></td>
|
||
<td>Phosphatidylcholine-sterol O-acyltransferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P10480">GCAT_AERHY</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1vig"><I>1vig</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1vig"><I>Eukaryotic type KH-domain (predicted)</I></A></td>
|
||
<td> </td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/3280033"><B>3280033</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>28</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.3.2.13"><B>2.3.2.13</B></A></td>
|
||
<td>Protein-glutamine gamma-glutamyltransferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P00488">F13A_HUMAN</A> <A href="http://www.uniprot.org/uniprot/P81453">TGAS_STRMB</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1FIE"><B>1FIE</B></A><BR><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1IU4"><B>1IU4</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1IU4">Cysteine proteinases</A></td>
|
||
<td center>Transglutaminase, microbial transglutaminase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/9839945,2901091,2877456"><B>9839945, 2901091, 2877456</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.3.2.13"><B>2.3.2.13</B></A></td>
|
||
<td>Protein-glutamine gamma-glutamyltransferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P40746">TGL_BACSU</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1ssq"><I>1ssq</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1ssq"><I>Single-stranded left-handed beta-helix (predicted)</I></A></td>
|
||
<td> </td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/9692191"><B>9692191</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>29</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.4.1.25"><B>2.4.1.25</B></A></td>
|
||
<td>4-a-glucanotransferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P15977">MALQ_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1FP8"><B>1FP8</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1FP8">TIM beta/alpha-barrel</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF02446">Glycosyl hydrolase family 77</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2845225"><B>2845225</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.4.1.25"><B>2.4.1.25</B></A></td>
|
||
<td>4-a-glucanotransferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/O32462">MALQ_THELI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1K1X"><B>1K1X</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1K1X">7-stranded beta/alpha barrel</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF03065">Glycosyl hydrolase family 57</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/12618437"><B>12618437</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=3>30</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.5.1.18"><B>2.5.1.18</B></A></td>
|
||
<td>Glutathione S-transferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P0A9D2">GST_ECOLI</A> <A href="http://www.uniprot.org/uniprot/Q9Y2Q3">GSTK1_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1A0F"><B>1A0F</B></A> <BR><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1R4W"><B>1R4W</B></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1A0F">Thioredoxin & GST C-terminal domain</A></td>
|
||
<td>Glutathione S-transferase, class beta, class kappa</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2185038,16081649,14717589"><B>2185038, 16081649, 14717589</B></A></td>
|
||
<td rowspan=3>Three distinct structural folds</td></tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.5.1.18"><B>2.5.1.18</B></A></td>
|
||
<td>Glutathione S-transferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P10620">MGST1_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2H8A"><B>2H8A</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2H8A">MAPEG domain</A></td>
|
||
<td>MAPEG family</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8812420,9278457,10091672,16806268"><B>8812420, 9278457, 10091672, 16806268</B></A></td>
|
||
</tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.5.1.18"><B>2.5.1.18</B></A></td>
|
||
<td>Glutathione S-transferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q56415">FOSA_SERMA</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1NPB"><B>1NPB</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1NPB">Glyoxalase/Bleomycin resistance protein</A></td>
|
||
<td center>Antibiotic resistance proteins</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/15075406,9115979"><B>15075406, 9115979</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center rowspan=2>31</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.6.1.44"><B>2.6.1.44</B></A></td>
|
||
<td>Alanine-glyoxylate aminotransferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P21549">SPYA_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1H0C"><B>1H0C</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1H0C">PLP-dependent transferases</A></td>
|
||
<td center>Cystathionine synthase-like</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2253628,12899834"><B>2253628, 12899834</B></A></td>
|
||
<td rowspan=2>Same fold, same superfamily, RMSD=3.8 Å</td>
|
||
</tr>
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.6.1.44"><B>2.6.1.44</B></A></td>
|
||
<td>Alanine-glyoxylate aminotransferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q64565">AGT2_RAT</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1Z3Z"><B>1Z3Z</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1Z3Z">PLP-dependent transferases</A></td>
|
||
<td center>GABA-aminotransferase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/7592550"><B>7592550</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center rowspan=3>32</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.7.1.2"><B>2.7.1.2</B></A></td>
|
||
<td>Glucose kinase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P0A6V8">GLK_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1SZ2"><B>1SZ2</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1SZ2">Ribonuclease H-like motif</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF02685">Glucokinase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/9023215"><B>9023215</B></A></td>
|
||
<td rowspan=3>Same fold, same superfamily. RMSD=4.2 Å vs 1Z6R (1.7 Å over 100 aa); RMSD=3.7 Å vs 1DGK</td></tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.7.1.2"><B>2.7.1.2</B></A></td>
|
||
<td>Glucose kinase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P0A4E1">GLK_STRCO</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1Z6R"><B>1Z6R</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1Z6R">Ribonuclease H-like motif</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF00480">ROK family</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1435260"><B>1435260</B></A></td>
|
||
</tr>
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.7.1.2"><B>2.7.1.2</B></A></td>
|
||
<td>Glucose kinase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P19367">HXK1_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1DGK"><B>1DGK</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1DGK">Ribonuclease H-like motif</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF00349">Hexokinase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1637300,9735292"><B>1637300, 9735292</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>33</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.7.1.4"><B>2.7.1.4</B></A></td>
|
||
<td>Fructokinase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P40713">SCRK_ECOLX</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1TZ6"><I>1TZ6</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1TZ6">Ribokinase-like</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF00294">PfkB family carbohydrate kinase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8278523"><B>8278523</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.7.1.4"><B>2.7.1.4</B></A></td>
|
||
<td>Fructokinase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q07211">SCRK_STRMU</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1XC3"><B>1XC3</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1XC3">Ribonuclease H-like motif</A></td>
|
||
<td center>Actin-like ATPase domain</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8336109"><B>8336109</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>34</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.7.1.11"><B>2.7.1.11</B></A></td>
|
||
<td>6-Phosphofructokinase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P0A796">K6PF1_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1PFK"><B>1PFK</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1PFK">Phosphofructokinase</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF00365">Phosphofructokinase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2975709"><B>2975709</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.7.1.11"><B>2.7.1.11</B></A></td>
|
||
<td>6-Phosphofructokinase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P06999">K6PF2_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=3CQD"><B>3CQD</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=3CQD">Ribokinase-like</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF00294">PfkB family carbohydrate kinase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/18762190,6310120"><B>18762190, 6310120</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>35</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.7.1.12"><B>2.7.1.12</B></A></td>
|
||
<td>Gluconokinase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P46859">GNTK_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1KNQ"><B>1KNQ</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1KNQ">P-loop NTPases</A></td>
|
||
<td center>Gluconate kinase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8655507,11468405"><B>8655507, 11468405</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.7.1.12"><B>2.7.1.12</B></A></td>
|
||
<td>Gluconokinase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P12011">GNTK_BACSU</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2ITM"><B>2ITM</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2ITM">Ribonuclease H-like motif</A></td>
|
||
<td center>Glycerol kinase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/3020045"><B>3020045</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>36</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.7.1.107"><B>2.7.1.107</B></A></td>
|
||
<td>Diacylglycerol kinase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P0ABN1">KDGL_ECOLI</A></td>
|
||
<td><center>N/A</td>
|
||
<td>Integral membrane protein</td>
|
||
<td><A href="http://pfam.xfam.org/family/PF01219">Prokaryotic diacylglycerol kinase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2984194,8071224,18611377"><B>2984194, 8071224, 18611377</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.7.1.107"><B>2.7.1.107</B></A></td>
|
||
<td>Diacylglycerol kinase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P49619">DGKG_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2QV7"><I>2qv7</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2QV7">NAD kinase (predicted)</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF00781">Diacylglycerol kinase catalytic domain</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8034597"><B>8034597</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center rowspan=2>37</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.7.4.3"><B>2.7.4.3</B></A></td>
|
||
<td>Adenylate kinase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P69441">KAD_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1AKE"><B>1AKE</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1AKE">P-loop NTPases</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF00406">Adenylate kinase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/9715904"><B>9715904</B></A></td>
|
||
<td rowspan=2>Same structural family, RMSD=3.6 Å</td></tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.7.4.3"><B>2.7.4.3</B></A></td>
|
||
<td>Adenylate kinase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P43411">KADA_METVO</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1NKS"><B>1NKS</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1NKS">P-loop NTPases</A></td>
|
||
<td center>Archaeal adenylate kinase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/7768791,9055821,9733648"><B>7768791, 9055821, 9733648</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center rowspan=2>38</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.7.7.2"><B>2.7.7.2</B></A></td>
|
||
<td>FAD synthetase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P38913">FAD1_YEAST</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=3G5A"><B>3G5A</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1sur">Adenine nucleotide alpha hydrolase (predicted)</A></td>
|
||
<td><A href="http://pfam.xfam.org/family?PF01507">PAPS reductase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/7799934,19375431"><B>7799934, 19375431</B></A></td>
|
||
<td rowspan=2>Same fold, different superfamilies, discussed in <A href="https://www.ncbi.nlm.nih.gov/pubmed/19375431">Huerta et al.</A>, RMSD=2.7 Å over 70 aa</td></tr>
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.7.7.2"><B>2.7.7.2</B></A></td>
|
||
<td>FAD synthetase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q59263">RIBF_CORAM</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1S4M"><B>1S4M</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1S4M">Adenine nucleotide alpha hydrolase</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF06574">FAD synthetase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/3023344,9454067"><B>3023344, 9454067</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center rowspan=2>39</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.7.7.4"><B>2.7.7.4</B></A></td>
|
||
<td>Sulfate adenylyltransferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P23845">CYSN_ECOLI</A> <A href="http://www.uniprot.org/uniprot/P21156">CYSD_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1ZUN"><B>1ZUN</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1ZUN">P-loop NTPases and Adenine nucleotide alpha hydrolase</A></td>
|
||
<td> </td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2828368"><B>2828368</B></A></td>
|
||
<td rowspan=2>CysD and MET3 belong to the same superfamily</td></tr>
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.7.7.4"><B>2.7.7.4</B></A></td>
|
||
<td>Sulfate adenylyltransferase </td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P08536">MET3_YEAST</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1JEE"><B>1JEE</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1JEE">Adenine nucleotide alpha hydrolase</A></td>
|
||
<td><A href="http://pfam.xfam.org/family/PF01747">ATP-sulfurylase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/11157739"><B>11157739</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>40</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.7.7.9"><B>2.7.7.9</B></A></td>
|
||
<td>UTP-glucose-1-phosphate uridylyltransferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P0AEP3">GALU_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2E3D"><B>2E3D</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1fxo">Nucleotide-diphospho-sugar transferases</A></td>
|
||
<td><A href="http://pfam.xfam.org/family?PF00483">Nucleotidyl transferase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/7961613,17322528"><B>7961613, 17322528</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td></tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.7.7.9"><B>2.7.7.9</B></A></td>
|
||
<td>UTP-glucose-1-phosphate uridylyltransferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q16851">UGPA_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2ICY"><I>2icy</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2icy">Single-stranded left-handed beta-helix</A></td>
|
||
<td><A href="http://pfam.xfam.org/family?PF01704">UTP-glucose-1-phosphate uridylyltransferase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8354390,17178129"><B>8354390, 17178129</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center rowspan=2>41</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.7.7.12"><B>2.7.7.12</B></A></td>
|
||
<td>Galactose-1-phosphate uridylyltransferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P09148">GAL7_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1GUP"><B>1GUP</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1GUP">HIT-like</A></td>
|
||
<td><A href="http://pfam.xfam.org/family?PF01087">Galactose-1-phosphate uridylyltransferase 1</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/321007,7669762"><B>321007, 7669762</B></A></td>
|
||
<td rowspan=2>Same fold, same superfamily</td></tr>
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.7.7.12"><B>2.7.7.12</B></A></td>
|
||
<td>Galactose-1-phosphate uridylyltransferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q00054">GALT_LACHE</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1gup"><i>1gup</i></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1gup">HIT-like (predicted)</A></td>
|
||
<td><A href="http://pfam.xfam.org/family?PF01087">Galactose-1-phosphate uridylyltransferase 2</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2066342"><B>2066342</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center rowspan=2>42</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.7.7.19"><B>2.7.7.19</B></A></td>
|
||
<td>Polynucleotide adenylyltransferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P0ABF1">PCNB_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1MIY"><B>1MIY</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1MIY">Nucleotidyltransferase & Poly A polymerase C-terminal region-like</A></td>
|
||
<td center>Poly A polymerase C-terminal region-like</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/10361280"><B>10361280</B></A></td>
|
||
<td rowspan=2>Same fold, same superfamily (catalytic domain), 17.3 Å over 188 aa</td></tr>
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.7.7.19"><B>2.7.7.19</B></A></td>
|
||
<td>Polynucleotide adenylyltransferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P51003">PAP_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1Q78"><B>1Q78</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1Q78">Nucleotidyltransferase & PAP/OAS1 substrate-binding domain & Ferredoxin-like</A></td>
|
||
<td center>Poly(A) polymerase, PAP, middle domain&</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/9061026"><B>9061026</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center rowspan=2>43</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.7.7.25"><B>2.7.7.25</B></A></td>
|
||
<td>tRNA adenylyltransferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P06961">CCA_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1VFG"><B>1VFG</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1VFG">Nucleotidyltransferase & Poly A polymerase C-terminal region-like</A></td>
|
||
<td>Bacterial CCA-adding enzyme type 1</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2204621"><B>2204621</B></A></td>
|
||
<td rowspan=2>Same fold, same superfamily (catalytic domain), RMSD=1.9 Å over 56 aa</td></tr>
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.7.7.25"><B>2.7.7.25</B></A></td>
|
||
<td>tRNA adenylyltransferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P77978">CCA_SULSH</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1UET"><B>1UET</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1UET">Nucleotidyltransferase & PAP/OAS1 substrate-binding domain & Ferredoxin-like</A></td>
|
||
<td center>Archaeal tRNA CCA-adding enzyme substrate-binding domain</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8809016,15590678"><B>8809016, 15590678</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>44</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.7.8.8"><B>2.7.8.8</B></A></td>
|
||
<td>CDP-diacylglycerol--serine O-phosphatidyltransferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P23830">PSS_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1BYR"><I>1BYR</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1BYR">Phospholipase D/nuclease</A></td>
|
||
<td><A href="http://pfam.xfam.org/family/PF00614">Phospholipase D Active site motif</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1323044,10074947"><B>1323044, 10074947</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/2.7.8.8"><B>2.7.8.8</B></A></td>
|
||
<td>CDP-diacylglycerol--serine O-phosphatidyltransferase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P08456">PSS_YEAST</A></td>
|
||
<td>N/A</td>
|
||
<td>Integral membrane protein</td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF01066">CDP-alcohol phosphatidyltransferase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/3040403"><B>3040403</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center rowspan=2>45</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.1.2.15"><B>3.1.2.15</B></A></td>
|
||
<td>Ubiquitin thiolesterase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P45974">UBP5_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2G43"><B>2G43</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2G43">Cysteine proteinases</A></td>
|
||
<td center>Ubiquitin carboxyl-terminal hydrolase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/7498549"><B>7498549</B></A></td>
|
||
<td rowspan=2>Different activities: cleave polyubiquitin chains linked, respectively, to Lys-48 and Lys-63</td></tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.1.2.15"><B>3.1.2.15</B></A></td>
|
||
<td>Ubiquitin thiolesterase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q96FJ0">STALP_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2ZNR"><B>2ZNR</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1r5x">Cytidine deaminase-like (predicted)</A></td></td>
|
||
<td>JAB1/MPN/Mov34 metalloenzyme</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/15314065,18758443"><B>15314065, 18758443</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=5>46</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.1.3.48"><B>3.1.3.48</B></A></td>
|
||
<td>Protein-tyrosine-phosphatase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P53433">PTPA_STRCO</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1D1P"><B>1D1P</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1D1P">Phosphotyrosine protein phosphatases I-like</A></td>
|
||
<td center>Low-molecular-weight phosphotyrosine protein phosphatases</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8550407,1304913"><B>8550407, 1304913</B></A></td>
|
||
<td rowspan=5>Five distinct structural folds</td></tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.1.3.48"><B>3.1.3.48</B></A></td>
|
||
<td>Protein-tyrosine-phosphatase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P23468">PTPRD_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1LAR"><B>1LAR</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1LAR">Phosphotyrosine protein phosphatases II</A></td>
|
||
<td center>Higher-molecular-weight phosphotyrosine protein phosphatases</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2170109,8833149"><B>2170109, 8833149</B></A></td>
|
||
</tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.1.3.48"><B>3.1.3.48</B></A></td>
|
||
<td>Protein-tyrosine-phosphatase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P30307">MPIP3_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1QB0"><B>1QB0</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1QB0">Rhodanese/Cell cycle control phosphatase</A></td>
|
||
<td center>Cell cycle control phosphatase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8276463"><B>8276463</B></A></td>
|
||
</tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.1.3.48"><B>3.1.3.48</B></A></td>
|
||
<td>Protein-tyrosine-phosphatase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P96717">YWQE_BACSU</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2ANU"><I>2ANU</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2ANU"><I>7-stranded beta/alpha barrel</I></A></td>
|
||
<td><A href="http://pfam.xfam.org/family/PF02811">PHP domain</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/15866923"><B>15866923</B></A></td>
|
||
</tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.1.3.48"><B>3.1.3.48</B></A></td>
|
||
<td>Protein-tyrosine-phosphatase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P97480">EYA3_MOUSE</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1JUD"><I>1JUD</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1JUD"><I>HAD-like</I></A></td>
|
||
<td><A href="http://pfam.xfam.org/family/PF00702">HAD-like hydrolase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/14628042,14628052"><B>14628042, 14628052</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>47</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.1"><B>3.2.1.1</B></A></td>
|
||
<td>Alpha-amylase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P25718">AMY1_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1EA9"><B>1EA9</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1EA9">TIM beta/alpha-barrel & Glycosyl hydrolase</A></td>
|
||
<td center>Alpha-amylase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/9268356"><B>9268356</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.1"><B>3.2.1.1</B></A></td>
|
||
<td>Alpha-amylase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P49067">AMYA_PYRFU</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1K1X"><B>1K1X</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1K1X">7-stranded beta/alpha barrel</A></td>
|
||
<td center>Glycosyl hydrolase family 57</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8226990"><B>8226990</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=7>48</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.4"><B>3.2.1.4</B></A></td>
|
||
<td>Cellulase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P10476">GUNA_PSEFL</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1UT9"><B>1UT9</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1UT9">Alpha/alpha toroid</A></td>
|
||
<td center>Glycosyl hydrolase family 9 (cellulase E)</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2851699"><B>2851699</B></A></td>
|
||
<td rowspan=7>At least four distinct structural folds</td></tr>
|
||
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.4"><B>3.2.1.4</B></A></td>
|
||
<td>Cellulase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P17901">GUNA_CLOCE</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1EDG"><B>1EDG</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1EDG">TIM beta/alpha-barrel</A></td>
|
||
<td center>Beta-glycanases</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1744052,8535787"><B>1744052, 8535787</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.4"><B>3.2.1.4</B></A></td>
|
||
<td>Cellulase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P33682">GUN1_STRHA</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2BOD"><B>2BOD</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2BOD">7-stranded beta/alpha barrel</A></td>
|
||
<td center>Glycosyl hydrolase family 6</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1400190"><B>1400190</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.4"><B>3.2.1.4</B></A></td>
|
||
<td>Cellulase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P55742">GUNM_CLOTM</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2FVG"><B>2FVG</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2FVG">Phosphorylase/hydrolase</A></td>
|
||
<td center>Cellulase M</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/protein/1097207"><B>GenBank</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.4"><B>3.2.1.4</B></A></td>
|
||
<td>Cellulase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P22669">GUN_ASPAC</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1KS4"><B>1KS4</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1KS4">Concanavalin A-like lectins/glucanases</A></td>
|
||
<td center>Glycosyl hydrolase family 11 (cellulase G)</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2249253,7586029,2379837"><B>2249253, 7586029, 2379837</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.4"><B>3.2.1.4</B></A></td>
|
||
<td>Cellulase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q05622">GUNE_RUMFL</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1L0H"><I>1L0H</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1L0H">Acyl carrier protein-like (predicted)</A></td>
|
||
<td> </td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8360615"><B>8360615</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.4"><B>3.2.1.4</B></A></td>
|
||
<td>Cellulase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P29719">GUNA_PAELA</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2EQD"><I>2EQD</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2EQD">TIM beta/alpha-barrel (predicted)</A></td>
|
||
<td> </td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/17905739"><B>17905739</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>49</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.8"><B>3.2.1.8</B></A></td>
|
||
<td>Endo-1,4-<2D>-xylanase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P23551">XYNA_BUTFI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1XAS"><B>1XAS</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1XAS">TIM beta/alpha-barrel</A></td>
|
||
<td center>beta-glycanases</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2198249,1909424"><B>2198249, 1909424</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.8"><B>3.2.1.8</B></A></td>
|
||
<td>Endo-1,4-<2D>-xylanase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P33558">XYNA2_CLOSR</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1QH6"><B>1QH6</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1QH6">Concanavalin A-like lectins/ glucanases</A></td>
|
||
<td center>Glycosyl hydrolase family 11 (cellulase G)</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/7763496"><B>7763496</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>50</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.11"><B>3.2.1.11</B></A></td>
|
||
<td>Dextranase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P39653">DEXT_STRDO</A></td>
|
||
<td>N/A</td>
|
||
<td> </td>
|
||
<td> </td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8021165"><B>8021165</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.11"><B>3.2.1.11</B></A></td>
|
||
<td>Dextranase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P48845">DEXT_PENMI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1OGM"><B>1OGM</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1OGM">Single-stranded right-handed beta-helix</A></td>
|
||
<td center>Glycosyl hydrolase family 28
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8905923,12962629"><B>8905923, 12962629</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>51</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.14"><B>3.2.1.14</B></A></td>
|
||
<td>Chitinase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P07254">CHIA_SERMA</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1RD6"><B>1RD6</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1RD6">TIM beta/alpha barrel</A></td>
|
||
<td center>Type II chitinase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/16453672,2203782,7592832,1542646"><B>PubMed</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.14"><B>3.2.1.14</B></A></td>
|
||
<td>Chitinase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P24626">CHI1_ORYSA</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2BAA"><B>2BAA</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2BAA">Lysozyme-like</A></td>
|
||
<td center>Family 19 glycosidase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1893114"><B>1893114</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=4>52</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.17"><B>3.2.1.17</B></A></td>
|
||
<td>Lysozyme</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P34020">LYS_CLOAB</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1JFX"><B>1JFX</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1JFX">TIM beta/alpha barrel</A></td>
|
||
<td center>1,4-beta-N-acetylmuraminidase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1599233,7649184"><B>1599233, 7649184</B></A></td>
|
||
<td rowspan=4>Two distinct structural folds</td></tr>
|
||
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.17"><B>3.2.1.17</B></A></td>
|
||
<td>Lysozyme</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q37875">LYS_BPP1</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1XJT"><B>1XJT</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1XJT">Lysozyme-like</A></td>
|
||
<td center>Phage lysozyme</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8576044,9514719"><B>8576044, 9514719</B></A></td>
|
||
</tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.17"><B>3.2.1.17</B></A></td>
|
||
<td>Lysozyme</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/A2RHZ5">ACMA_LACLM</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2ZYC"><B>2ZYC</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=153L"><I>Lysozyme-like</I></A></td>
|
||
<td>Glycosyl hydrolase family 73</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/7883712,10049388,19351587"><B>7883712, 10049388, 19351587</B></A></td>
|
||
</tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.17"><B>3.2.1.17</B></A></td>
|
||
<td>Lysozyme</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P10773">LYB_BACSU</A></td>
|
||
<td>N/A</td>
|
||
<td>N/A</td>
|
||
<td> </td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/3148618"><B>3148618</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>53</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.20"><B>3.2.1.20</B></A></td>
|
||
<td>Alpha-glucosidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q02751">MALT_CANAL</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1JI1"><B>1JI1</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1JI1">TIM beta/alpha barrel & Glycosyl-hydrolase domain</A></td>
|
||
<td center>Glycosyl hydrolase family 13</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1400249"><B>1400249</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td></tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.20"><B>3.2.1.20</B></A></td>
|
||
<td>Alpha-glucosidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/O33830">AGLA_THEMA</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1OBB"><B>1OBB</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1OBB">Rossmann-fold & LDH C-terminal domain</A></td>
|
||
<td>Glycosyl hydrolase family 4</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/12062450,10972187"><B>12062450, 10972187</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center rowspan=2>54</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.21"><B>3.2.1.21</B></A></td>
|
||
<td>Beta-glucosidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q08638">BGLA_THEMA</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1OIF"><B>1OIF</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1OIF">TIM beta/alpha barrel</A></td>
|
||
<td><A href="http://pfam.xfam.org/family/PF00232">Glycosyl hydrolase family 1</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8277941,14624580"><B>8277941, 14624580</B></A></td>
|
||
<td rowspan=2>Same fold, same superfamily, RMSD=4.3 Å</td></tr>
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.21"><B>3.2.1.21</B></A></td>
|
||
<td>Beta-glucosidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P16084">BGLS_BUTFI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1OBB"><B>1X38</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1OBB">TIM beta/alpha barrel</A></td>
|
||
<td>Glycosyl hydrolase family 3</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2262790"><B>2262790</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>55</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.22"><B>3.2.1.22</B></A></td>
|
||
<td>Alpha-galactosidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P27756">AGAL_STRMU</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1ZY9"><B>1ZY9</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1ZY9">TIM beta/alpha barrel</A></td>
|
||
<td><A href="http://pfam.xfam.org/family/PF02065">Glycosyl hydrolase family 36</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1649890"><B>1649890</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.22"><B>3.2.1.22</B></A></td>
|
||
<td>Alpha-galactosidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P16551">AGAL_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1OBB"><B>1OBB</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1OBB">Rossmann-fold & LDH C-terminal_domain</A></td>
|
||
<td>Glycosyl hydrolase family 4</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2831880"><B>2831880</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center rowspan=2>56</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.23"><B>3.2.1.23</B></A></td>
|
||
<td>Beta-galactosidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P00722">BGAL_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1BGL"><B>1BGL</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1BGL">TIM beta/alpha-barrel</A></td>
|
||
<td>Glycosyl hydrolase family 2</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/11732897"><B>11732897</B></A></td>
|
||
<td rowspan=2>Same fold, same superfamily</td></tr>
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.23"><B>3.2.1.23</B></A></td>
|
||
<td>Beta-galactosidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P14288">BGAL_SULAC</A></td>
|
||
<td> </td>
|
||
<td>TIM beta/alpha-barrel</td>
|
||
<td>Glycosyl hydrolase family 1</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2508066"><B>2508066</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center rowspan=2>57</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.28"><B>3.2.1.28</B></A></td>
|
||
<td>Alpha,alpha-trehalase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P13482">TREA_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2JG0"><B>2JG0</B></A></td>
|
||
<td><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2JG0">Alpha/alpha toroid</A></td>
|
||
<td><A href="http://pfam.xfam.org/family/PF01204">Glycosyl hydrolase family 37</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2820965,17455176"><B>2820965, 17455176</B></A></td>
|
||
<td rowspan=2>Same fold, same superfamily</td></tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.28"><B>3.2.1.28</B></A></td>
|
||
<td>Alpha,alpha-trehalase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P78617">TREA_EMENI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1H54"><I>1H54</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1H54"><I>Alpha/alpha_toroid (predicted)</I></A></td>
|
||
<td center>Glycosyl hydrolase family 65</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/9140977"><B>9140977</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=3>58</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.35"><B>3.2.1.35</B></A></td>
|
||
<td>Hyaluronidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q12891">HYAL2_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1FCU"><B>1FCU</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1FCU">TIM beta/alpha barrel</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF01630">Glycosyl hydrolase family 56</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/9712871,17503783"><B>9712871, 17503783</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td></tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.35"><B>3.2.1.35</B></A></td>
|
||
<td>Hyaluronidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q54699">HYLP2_BPH45</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2PK1"><B>2PK1</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2PK1">Triple-stranded beta-helix</A></td>
|
||
<td><A href="http://pfam.xfam.org/family/PF07212">Hyaluronidase_1</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/7622224"><B>7622224</B></A></td>
|
||
</tr>
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.35"><B>3.2.1.35</B></A></td>
|
||
<td>Hyaluronidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P50828">HEMO_PIG</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1HXN"><B>1HXN</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1HXN">4-bladed beta-propeller</A></td>
|
||
<td center>Hemopexin domain</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/7798203,8590016"><B>7798203, 8590016</B></A></td>
|
||
<td>Most likely a mistake</td></tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=3>59</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.37"><B>3.2.1.37</B></A></td>
|
||
<td>Xylan 1,4-<2D>-xylosidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P07129">XYNB_BACPU</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1YIF"><B>1YIF</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1YIF">5-bladed beta-propeller</A></td>
|
||
<td center>Glycosyl hydrolase family 43</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2440680,7766665"><B>2440680, 7766665</B></A></td>
|
||
<td rowspan=3>Three distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.37"><B>3.2.1.37</B></A></td>
|
||
<td>Xylan 1,4-<2D>-xylosidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P36906">XYNB_THESA</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1PX8"><B>1PX8</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1PX8">TIM beta/alpha barrel</A></td>
|
||
<td center>Glycosyl hydrolase family 39</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8612648"><B>8612648</B></A></td>
|
||
</tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.37"><B>3.2.1.37</B></A></td>
|
||
<td>Xylan 1,4-<2D>-xylosidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P45702">XYLA1_BACST</A></td>
|
||
<td>N/A</td>
|
||
<td>N/A</td>
|
||
<td>Glycosyl hydrolase family 52</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8074507,11322943"><B>8074507, 11322943</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=3>60</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.39"><B>3.2.1.39</B></A></td>
|
||
<td>Glucan endo-1,3-<2D>-D-glucosidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P33157">E13A_ARATH</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2CYG"><B>2CYG</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2CYG">TIM beta/alpha barrel</A></td>
|
||
<td center>Glycosyl hydrolase family 17</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/11405630,16421930"><B>11405630, 16421930</B></A></td>
|
||
<td rowspan=3>Three distinct structural folds</td></tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.39"><B>3.2.1.39</B></A></td>
|
||
<td>Glucan endo-1,3-<2D>-D-glucosidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P23903">E13B_BACCI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1UPS"><I>1UPS</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1UPS">Concanavalin A-like lectins/ glucanases</A></td>
|
||
<td center>Glycosyl hydrolase family 16</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2311931"><B>2311931</B></A></td>
|
||
</tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.39"><B>3.2.1.39</B></A></td>
|
||
<td>Glucan endo-1,3-<2D>-D-glucosidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P22222">E13B_CELCE</A></td>
|
||
<td>N/A</td>
|
||
<td>N/A</td>
|
||
<td>Glycosyl hydrolase family 64</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1985933"><B>1985933</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=3>61</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.55"><B>3.2.1.55</B></A></td>
|
||
<td>Alpha-N-arabinofuranosidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P53627">ABFA_STRLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2C7F"><B>2C7F</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2C7F">TIM beta/alpha barrel</A></td>
|
||
<td center>Glycosyl hydrolase family 51</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8092996,16336192"><B>8092996, 16336192</B></A></td>
|
||
<td rowspan=3>Three distinct structural folds</td></tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.55"><B>3.2.1.55</B></A></td>
|
||
<td>Alpha-N-arabinofuranosidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P45982">XYLB_BUTFI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1YRZ"><B>1YRZ</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1YRZ">Concanavalin A-like lectins/glucanases & 5-bladed beta-propeller</A></td>
|
||
<td center>Glycosyl hydrolase family 43</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1905520,18980579"><B>1905520, 18980579</B></A></td>
|
||
</tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.55"><B>3.2.1.55</B></A></td>
|
||
<td>Alpha-N-arabinofuranosidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P23031">XYNC_PSEFL</A></td>
|
||
<td>N/A</td>
|
||
<td><I>5-bladed beta-propeller (predicted)</I></td>
|
||
<td>Glycosyl hydrolase family 62</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2125205"><B>2125205</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>62</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.58"><B>3.2.1.58</B></A></td>
|
||
<td>Glucan 1,3-<2D>-glucosidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P29717">EXG_CANAL</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2PB1"><B>2PB1</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2PB1">TIM beta/alpha barrel</A></td>
|
||
<td>Glycosyl hydrolase family 5 (cellulase A)</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8436950,10610795"><B>8436950, 10610795</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.58"><B>3.2.1.58</B></A></td>
|
||
<td>Glucan 1,3-<2D>-glucosidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P49426">EXG1_COCCA</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=3EQO"><B>3EQO</B></A></td>
|
||
<td center><I>Single-stranded right-handed beta-helix</I></td>
|
||
<td>Glycosyl hydrolase family 55</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8135518"><B>8135518</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=3>63</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.73"><B>3.2.1.73</B></A></td>
|
||
<td>Licheninase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P07979">GUB_NICPL</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2CYG"><B>2CYG</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2CYG">TIM beta/alpha barrel</A></td>
|
||
<td center>Glycosyl hydrolase family 17</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/9452466, 8146192, 2152158"><B>PubMed</B></A></td>
|
||
<td rowspan=3>Three distinct structural folds</td></tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.73"><B>3.2.1.73</B></A></td>
|
||
<td>Licheninase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P04957">GUB_BACSU</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1GBG"><B>1GBG</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1GBG">Concanavalin A-like lectins/glucanases</A></td>
|
||
<td center>Glycosyl hydrolase family 16</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1740123"><B>1740123</B></A></td>
|
||
</tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.73"><B>3.2.1.73</B></A></td>
|
||
<td>Licheninase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P19254">GUB_BACCI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1V5C"><B>1V5C</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1V5C">Alpha/alpha toroid</A></td>
|
||
<td center>Glycosyl hydrolase family 8 (cellulase D)</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2377467"><B>2377467</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center rowspan=2>64</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.78"><B>3.2.1.78</B></A></td>
|
||
<td>Mannan endo-1,4-<2D>-mannosidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P49424">MANA_PSEFL</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1GW1"><B>1GW1</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1GW1">TIM beta/alpha barrel</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF02156">Glycosyl hydrolase family 26</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/7848261,12203498"><B>7848261, 12203498</B></A></td>
|
||
<td rowspan=2>Same fold, same superfamily, RMSD=5.0 Å</td></tr>
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.78"><B>3.2.1.78</B></A></td>
|
||
<td>Mannan endo-1,4-<2D>-mannosidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P22533">MANB_CALSA</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1BQC"><B>1BQC</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1BQC">TIM beta/alpha barrel</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF00150">Glycosyl hydrolase family 5</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1476429"><B>1476429</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=3>65</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.81"><B>3.2.1.81</B></A></td>
|
||
<td><EFBFBD>-agarase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P07883">AGAR_STRCO</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1QOX"><B>1QOX</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1QOX">TIM beta/alpha barrel</A></td>
|
||
<td center>Glycosyl hydrolase family 1</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/3034860"><B>3034860</B></A></td>
|
||
<td rowspan=3>Predicted two distinct structural folds</td></tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.81"><B>3.2.1.81</B></A></td>
|
||
<td><EFBFBD>-agarase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P48839">AGAA_VIBS7</A></td>
|
||
<td>N/A</td>
|
||
<td>N/A</td>
|
||
<td>Glycosyl hydrolase family 50</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8285681"><B>8285681</B></A></td>
|
||
</tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.81"><B>3.2.1.81</B></A></td>
|
||
<td><EFBFBD>-agarase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P13734">AGAR_ALTAT</A></td>
|
||
<td>N/A</td>
|
||
<td>N/A</td>
|
||
<td>Glycosyl hydrolase family 86</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2914859"><B>2914859</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>66</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.86"><B>3.2.1.86</B></A></td>
|
||
<td>6-phospho-<2D>-glucosidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P11988">BGLB_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1QOX"><B>1QOX</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1QOX">TIM beta/alpha barrel</A></td>
|
||
<td center>Glycosyl hydrolase family 1</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/3034860"><B>3034860</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td></tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.1.86"><B>3.2.1.86</B></A></td>
|
||
<td>6-phospho-<2D>-glucosidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P17411">CHBF_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1S6Y"><B>1S6Y</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1S6Y">Rossmann-fold & LDH C-terminal domain</A></td>
|
||
<td center>Glycosyl hydrolase family 4</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/10572139"><B>10572139</B></A></td>
|
||
</tr>
|
||
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>67</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.2.21"><B>3.2.2.21</B></A></td>
|
||
<td>DNA-3-methyladenine glycosylase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P04395">3MG2_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1MPG"><B>1MPG</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1MPG">DNA-glycosylase & TBP-like</A></td>
|
||
<td center> </td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/6389535"><B>6389535</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.2.2.21"><B>3.2.2.21</B></A></td>
|
||
<td>DNA-3-methyladenine glycosylase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P29372">3MG_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1F4R"><B>1F4R</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1F4R">FMT C-terminal domain-like</A></td>
|
||
<td center> </td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8589517,1645538"><B>8589517, 1645538</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=3>68</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.5.1.1"><B>3.5.1.1</B></A></td>
|
||
<td>Asparaginase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P38986">ASPG1_YEAST</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1HFW"><B>1HFW</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1HFW">Glutaminase/Asparaginase</A></td>
|
||
<td center>Glutaminase/Asparaginase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8026756"><B>8026756</B></A></td>
|
||
<td rowspan=3>At least two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.5.1.1"><B>3.5.1.1</B></A></td>
|
||
<td>Asparaginase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P20933">ASPG_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1APY"><B>1APY</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1APY">Ntn_hydrolase-like</A></td>
|
||
<td center>(Glycosyl)asparaginase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1840528"><B>1840528</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.5.1.1"><B>3.5.1.1</B></A></td>
|
||
<td>Asparaginase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q9RFN5">Q9RFN5_RHIET</A></td>
|
||
<td center>N/A</td>
|
||
<td center>N/A</td>
|
||
<td><A href="http://pfam.xfam.org/family?PF06089">L-asparaginase II</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/10930734"><B>10930734</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>69</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.5.1.4"><B>3.5.1.4</B></A></td>
|
||
<td>Amidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P27765">AMID_PSECL</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1OCK"><B>1OCK</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1OCK">Amidase signature</A></td>
|
||
<td><A href="http://pfam.xfam.org/family?PF01425">Amidase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2013568"><B>2013568</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.5.1.4"><B>3.5.1.4</B></A></td>
|
||
<td>Amidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P11436">AMIE_PSEAE</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2UXY"><B>2UXY</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1FO6">Carbon-nitrogen hydrolase</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family?PF00795">Carbon-nitrogen hydrolase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/87219101"><B>87219101</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center rowspan=2>70</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.5.1.11"><B>3.5.1.11</B></A></td>
|
||
<td>Penicillin acylase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P06875">PAC_ECOLX</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1PNL"><B>1PNL</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1PNL">Ntn hydrolase-like</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family?PF01804">Penicillin amidase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/9292993,7816145"><B>9292993, 7816145</B></A></td>
|
||
<td rowspan=2>Same fold, same supefamily, RMSD=2.9 Å</td></tr>
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.5.1.11"><B>3.5.1.11</B></A></td>
|
||
<td>Penicillin acylase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P12256">PAC_BACSH</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2PVA"><B>2PVA</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2PVA">Ntn hydrolase-like</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family?PF02275">Linear amide C-N hydrolases</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/10331865"><B>10331865</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>71</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.5.1.28"><B>3.5.1.28</B></A></td>
|
||
<td>N-acetylmuramoyl-L-alanine amidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P13016">AMPD_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1J3G"><B>1J3G</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1J3G">N-acetylmuramoyl-L-alanine amidase-like</A></td>
|
||
<td center>N-acetylmuramoyl-L-alanine amidase-like</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/12654266"><B>12654266</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td></tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.5.1.28"><B>3.5.1.28</B></A></td>
|
||
<td>N-acetylmuramoyl-L-alanine amidase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P26365">AMIB_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1JWQ"><I>1JWQ</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1JWQ">Phosphorylase/hydrolase-like</A></td>
|
||
<td center>Zn-dependent exopeptidases</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/7511774"><B>7511774</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td center rowspan=2>72</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.5.2.6"><B>3.5.2.6</B></A></td>
|
||
<td><EFBFBD>-Lactamase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P00811">AMPC_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2BLS"><B>2BLS</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2BLS">Beta-lactamase/ transpeptidase-like</A></td>
|
||
<td center>Beta-lactamase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/6795623"><B>6795623</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td></tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.5.2.6"><B>3.5.2.6</B></A></td>
|
||
<td><EFBFBD>-Lactamase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P14488">BLAB_BACCE</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1BC2"><B>1BC2</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1BC2">Metallo-hydrolase/ oxidoreductase</A></td>
|
||
<td center>Zn metallo-beta-lactamase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/9730812"><B>9730812</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td rowspan=4>73</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.6.1.1"><B>3.6.1.1</B></A></td>
|
||
<td>Inorganic diphosphatase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P21216">IPYR_ARATH</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1TWL"><B>1TWL</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1TWL">OB-fold</A></td>
|
||
<td><A href="http://pfam.xfam.org/family?PF00719"> Pyrophosphatase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/654155"><B>654155</B></A></td>
|
||
<td rowspan=4>Four distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.6.1.1"><B>3.6.1.1</B></A></td>
|
||
<td>Inorganic diphosphatase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P31414">AVP1_ARATH</A></td>
|
||
<td>N/A</td>
|
||
<td>Integral membrane protein</td>
|
||
<td><A href="http://pfam.xfam.org/family?PF03030">Inorganic H+ pyrophosphatase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/9268385"><B>9268385</B></A></td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.6.1.1"><B>3.6.1.1</B></A></td>
|
||
<td>Inorganic diphosphatase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P37487">PPAC_BACSU</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1WPM"><B>1WPM</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1WPM">DHH phosphoesterases</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family?PF01368"> DHH hydrolase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/9845334,11697905"><B>9845334, 11697905</B></A></td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.6.1.1"><B>3.6.1.1</B></A></td>
|
||
<td>Inorganic diphosphatase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q9JMQ2">PPAX_BACSU</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2HDO"><I>2HDO</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2HDO">HAD-like</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family?PF00702"> HAD-like hydrolase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/12359880"><B>12359880</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td rowspan=3>74</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.6.1.5"><B>3.6.1.5</B></A></td>
|
||
<td>Apyrase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P50635">APY_AEDAE</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1HP1"><I>1HP1</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1HP1">5-nucleotidase & Metallo-dependent phosphatases</A></td>
|
||
<td center>5'-nucleotidase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2173922"><B>2173922</B></A></td>
|
||
<td rowspan=3>Three distinct structural folds</td></tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.6.1.5"><B>3.6.1.5</B></A></td>
|
||
<td>Apyrase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/O75355">ENTP3_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1T6C"><I>1T6C</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1T6C">Ribonuclease H-like</A></td>
|
||
<td center>Actin-like ATPase domain</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/9675246,8955160"><B>9675246, 8955160</B></A></td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.6.1.5"><B>3.6.1.5</B></A></td>
|
||
<td>Apyrase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/O96559">APY_CIMLE</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2H2N"><B>2H2N</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2H2N">5-bladed beta-propeller</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family?PF06079"> Apyrase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/9804829,15006348"><B>9804829, 15006348</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td rowspan=2>75</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.6.1.11"><B>3.6.1.11</B></A></td>
|
||
<td>Exopolyphosphatase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P29014">PPX_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1U6Z"><B>1U6Z</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1U6Z">HD-domain/PDEase-like & Ribonuclease H-like</A></td>
|
||
<td center>Ppx associated domain</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8212131"><B>8212131</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.6.1.11"><B>3.6.1.11</B></A></td>
|
||
<td>Exopolyphosphatase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P38698">PPX1_YEAST</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1K20"><I>1K20</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1K20">DHH phosphoesterases</A></td>
|
||
<td center>Mn-dependent inorganic pyrophosphatase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/7860598"><B>7860598</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td rowspan=3>76</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.6.1.17"><B>3.6.1.17</B></A></td>
|
||
<td>Bis(5'-nucleosyl) -tetraphosphatase (asymmetrical)</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P49776">APH1_SCHPO</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1FHI"><B>1FHI</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1FHI">HIT-like</A></td>
|
||
<td center>HIT family</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8554540"><B>8554540</B></A></td>
|
||
<td rowspan=3>Three distinct structural folds</td></tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.6.1.17"><B>3.6.1.17</B></A></td>
|
||
<td>Bis(5'-nucleosyl) -tetraphosphatase (asymmetrical)</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P50583">AP4A_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1XSA"><B>1XSA</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1XSA">Nudix</A></td>
|
||
<td center>MutT-like</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/7487923"><B>7487923</B></A></td>
|
||
</tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.6.1.17"><B>3.6.1.17</B></A></td>
|
||
<td>Bis(5'-nucleosyl) -tetraphosphatase (asymmetrical)</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/O31614">PRPE_BACSU</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1G5B"><I>1G5B</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1G5B">Metallo-dependent phosphatases</A></td>
|
||
<td center>Protein serine/threonine phosphatase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/12059787"><B>12059787</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center rowspan=2>77</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.8.1.2"><B>3.8.1.2</B></A></td>
|
||
<td>2-Haloalkanoate dehalogenase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P24069">HAD1_PSEUC</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1QQ5"><B>1QQ5</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1QQ5">HAD-like</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family?PF00702"> HAD-like hydrolase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1556080,10521454"><B>1556080, 10521454</B></A></td>
|
||
<td rowspan=2>Different stereospecificity</td></tr>
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.8.1.9"><B>3.8.1.9</B></A></td>
|
||
<td>2-Haloalkanoate dehalogenase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q52086">HADD_PSEPU</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=3BJX"><B>3BJX</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=3BJX">N/A</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family?PF10778"> Haloacid dehalogenase DehI</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1556080,18353360"><B>1556080, 18353360</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td rowspan=2>78</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.8.1.3"><B>3.8.1.3</B></A></td>
|
||
<td>Haloacetate dehalogenase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q01398">DEH1_MORSB</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1G5F"><B>1G5F</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1G5F">Alpha/beta-hydrolases</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family?PF00561"> Alpha/beta hydrolase_1</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1512562,11939779"><B>1512562, 11939779</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td></tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/3.8.1.3"><B>3.8.1.3</B></A></td>
|
||
<td>Haloacetate dehalogenase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q01399">DEH2_MORSB</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1JUD"><B>1JUD</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1JUD">HAD-like</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family?PF00702"> HAD-like hydrolase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8702766"><B>8702766</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td rowspan=2>79</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.1.1.17"><B>4.1.1.17</B></A></td>
|
||
<td>Ornithine decarboxylase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P24169">DCOS_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1ORD"><B>1ORD</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1ORD">PLP-dependent transferase</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family?PF01276"> Orn/Lys/Arg decarboxylase, class I</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/7563080"><B>7563080</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td></tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.1.1.17"><B>4.1.1.17</B></A></td>
|
||
<td>Ornithine decarboxylase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P11926">DCOR_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1D7K"><B>1D7K</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1D7K">TIM beta/alpha barrel</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family?PF00278"> Orn/Lys/Arg decarboxylase class II</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2587220,2318872"><B>2587220, 2318872</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td rowspan=3>80</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.1.1.19"><B>4.1.1.19</B></A></td>
|
||
<td>Arginine decarboxylase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P28629">ADIA_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2VYC"><B>2VYC</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1ORD">PLP-dependent transferase</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family?PF01276"> Orn/Lys/Arg decarboxylase, class I</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8383109,19298070 "><B>8383109, 19298070 </B></A></td>
|
||
<td rowspan=3>Three distinct structural folds</td></tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.1.1.19"><B>4.1.1.19</B></A></td>
|
||
<td>Arginine decarboxylase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P21170">SPEA_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1TWI"><B>1TWI</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1TWI">TIM beta/alpha barrel</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family?PF00278"> Orn/Lys/Arg decarboxylase class II</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/4571773"><B>4571773</B></A></td>
|
||
</tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.1.1.19"><B>4.1.1.19</B></A></td>
|
||
<td>Arginine decarboxylase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q57764">PDAD_METJA</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1N2M"><B>1N2M</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1N2M">Pyruvoyl-dependent histidine and arginine decarboxylases</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family?PF01862"> Pyruvoyl-dependent ArgDC</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/11980912"><B>11980912</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td rowspan=2>81</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.1.1.22"><B>4.1.1.22</B></A></td>
|
||
<td>Histidine decarboxylase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P28577">DCHS_ENTAE</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1JS3"><I>1JS3</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1JS3">PLP-dependent transferase</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family?PF00282"> Pyridoxal-dependent decarboxylase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2033044"><B>2033044</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.1.1.22"><B>4.1.1.22</B></A></td>
|
||
<td>Histidine decarboxylase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P00862">DCHS_LACS3</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1HQ6"><B>1HQ6</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1HQ6">Pyruvoyl-dependent histidine and arginine decarboxylases</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family?PF02329"> Histidine decarboxylase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2857718"><B>2857718</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td rowspan=2>82</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.1.1.50"><B>4.1.1.50</B></A></td>
|
||
<td>S-adenosylmethionine decarboxylase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P0A7F6">SPED_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1TLU"><B>1TLU</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1TLU">S-adenosylmethionine decarboxylase</A></td>
|
||
<td><A href="http://pfam.xfam.org/family?PF02675"> SAM decarboxylase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/3546296,17567041"><B>3546296, 17567041</B></A></td>
|
||
<td rowspan=2>Same fold, same superfamily, RMSD=1.6 Å over 81 aa</td></tr>
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.1.1.50"><B>4.1.1.50</B></A></td>
|
||
<td>S-adenosylmethionine decarboxylase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P17707">DCAM_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1MSV"><B>1MSV</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1MSV">S-adenosylmethionine decarboxylase</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family?PF01536"> SAM decarboxylase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/10378277"><B>10378277</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td rowspan=2>83</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.1.2.13"><B>4.1.2.13</B></A></td>
|
||
<td>Fructose 1,6-bisphosphate aldolase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P0AB71">ALF_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1DOS"><B>1DOS</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1DOS">TIM beta/alpha barrel</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF01116">Fructose-bisphosphate aldolase class II</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8436219,8836102"><B>8436219, 8836102</B></A></td>
|
||
<td rowspan=2>Same fold, same superfamily, RMSD=4.7 Å</td></tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.1.2.13"><B>4.1.2.13</B></A></td>
|
||
<td>Fructose 1,6-bisphosphate aldolase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P04075">ALDOA_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1ALD"><B>1ALD</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1ALD">TIM beta/alpha barrel</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF00274">Fructose-bisphosphate aldolase class I</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/3355497,2335208"><B>3355497, 2335208</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td rowspan=2>84</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.1.2.15"><B>4.1.2.15</B></A></td>
|
||
<td>Phospho-2-keto-3-deoxyheptonate aldolase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P0AB91">AROG_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1GG1"><B>1GG1</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1GG1">TIM beta/alpha barrel</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF00793">DAHP synthetase I</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/10425687"><B>10425687</B></A></td>
|
||
<td rowspan=2>Same fold, same superfamily, RMSD=4.3 Å</td></tr>
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.1.2.15"><B>4.1.2.15</B></A></td>
|
||
<td>Phospho-2-keto-3-deoxyheptonate aldolase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P80574">AROF_STRCO</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2B7O"><B>2B7O</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2B7O">TIM beta/alpha barrel</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF01474">Class-II DAHP synthetase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8760910,16288916"><B>8760910, 16288916</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td rowspan=2>85</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.1.2.40"><B>4.1.2.40</B></A></td>
|
||
<td>Tagatose 1,6-bisphosphate aldolase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P0AB74">KBAY_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1GVF"><B>1GVF</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1GVF">TIM beta/alpha barrel</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF01116">Fructose-bisphosphate aldolase class II</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/11940603"><B>11940603</B></A></td>
|
||
<td rowspan=2>Same fold, same superfamily, RMSD=3.7 Å</td></tr>
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.1.2.40"><B>4.1.2.40</B></A></td>
|
||
<td>Tagatose 1,6-bisphosphate aldolase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P26593">LACD_LACLA</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1TO3"><B>1TO3</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1TO3">TIM beta/alpha barrel</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF01791">DeoC/LacD family aldolase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1901863"><B>1901863</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td rowspan=3>86</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.2.1.1"><B>4.2.1.1</B></A></td>
|
||
<td>Carbonate dehydratase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P17582">CYNT_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1EKJ"><I>1EKJ</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1EKJ">Resolvase-like</A></td>
|
||
<td center>beta-carbonic anhydrase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1740425"><B>1740425</B></A></td>
|
||
<td rowspan=3>Three distinct structural folds</td></tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.2.1.1"><B>4.2.1.1</B></A></td>
|
||
<td>Carbonate dehydratase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P00915">CAH1_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2FOY"><B>2FOY</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2FOY">Carbonic anhydrase</A></td>
|
||
<td> </td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/804171,4207120"><B>804171, 4207120</B></A></td>
|
||
</tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.2.1.1"><B>4.2.1.1</B></A></td>
|
||
<td>Carbonate dehydratase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P40881">CAH_METTE</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1QQ0"><B>1QQ0</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1QQ0">Single-stranded left-handed beta-helix</A></td>
|
||
<td center>gamma-carbonic anhydrase-like</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8041719"><B>8041719</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td rowspan=2>87</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.2.1.2"><B>4.2.1.2</B></A></td>
|
||
<td>Fumarate hydratase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P00923">FUMA_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2ISB"><B>2ISB</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2ISB">The swivelling beta/beta/alpha domain</A></td>
|
||
<td center>Class I fumarase family</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1917897"><B>1917897</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td></tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.2.1.2"><B>4.2.1.2</B></A></td>
|
||
<td>Fumarate hydratase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P05042">FUMC_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1FUO"><B>1FUO</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1FUO">L-aspartase-like</A></td>
|
||
<td center>L-aspartase/fumarase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8909293,3282546"><B>8909293, 3282546</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td rowspan=2>88</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.2.1.10"><B>4.2.1.10</B></A></td>
|
||
<td>3-dehydroquinate dehydratase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P43877">AROQ_ACTPL</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1UQR"><B>1UQR</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1UQR">Flavodoxin-like</A></td>
|
||
<td center>Type II 3-dehydroquinate dehydratase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/14993670, 8170389, 2848727"><B>PubMed</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td></tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.2.1.10"><B>4.2.1.10</B></A></td>
|
||
<td>3-dehydroquinate dehydratase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P05194">AROD_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1QFE"><B>1QFE</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1QFE">TIM beta/alpha barrel</A></td>
|
||
<td center>Class I aldolase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/3541912"><B>3541912</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<td rowspan=2>89</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.3.1.17"><B>4.2.1.13</B></A></td>
|
||
<td>L-serine ammonia-lyase (now <A href="http://enzyme.expasy.org/EC/4.3.1.17"><B>EC 4.3.1.17</B></A>)</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P16095">SDHL_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2IQQ"><B>2IQQ</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2IQQ">FwdE/GAPDH domain</A></td>
|
||
<td center><A href="http://www.ebi.ac.uk/interpro/IEntry?ac=IPR004644">FeS-dependent L-serine dehydratase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2504697"><B>2504697</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td></tr>
|
||
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.3.1.17"><B>4.2.1.13</B></A></td>
|
||
<td>L-serine ammonia-lyase (now <A href="http://enzyme.expasy.org/EC/4.3.1.17"><B>EC 4.3.1.17</B></A>)</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P20132">SDHL_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1PWH"><B>1PWH</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1PWH">Tryptophan synthase beta subunit-like PLP-dependent enzymes</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF01791">DeoC/LacD family aldolase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/14596599"><B>14596599</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td rowspan=2>90</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.2.1.51"><B>4.2.1.51</B></A></td>
|
||
<td>Prephenate dehydratase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P0A9J8">PHEA_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2QMW"><B>2QMW</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2QMW">Periplasmic binding protein-like II</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF00800">Prephenate dehydratase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/18171624"><B>18171624</B></A></td>
|
||
<td rowspan=2>Same fold, same superfamily, RMSD=1.8 Å over 59 aa</td></tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.2.1.51"><B>4.2.1.51</B></A></td>
|
||
<td>Prephenate dehydratase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q01269">PHEC_PSEAE</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1XT8"><B>1XT8</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1XT8">Periplasmic binding protein-like II</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF00497">Bacterial extracellular solute-binding proteins</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/92129331"><B>92129331</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td rowspan=4>91</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.2.2.2"><B>4.2.2.2</B></A></td>
|
||
<td>Pectate lyase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P0C1C2">PEL3_ERWCA</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1PLU"><B>1PLU</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1PLU">Single-stranded right-handed beta-helix</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF00544">Pectate lyase C</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/12226275"><B>12226275</B></A></td>
|
||
<td rowspan=4>Two distinct structural folds, different families</td></tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.2.2.2"><B>4.2.2.2</B></A></td>
|
||
<td>Pectate lyase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P14005">PELP_PECCC</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2V8K"><B>2V8K</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1NXC">Alpha/alpha toroid</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF06917">Periplasmic pectate lyase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2695748,17881361"><B>2695748, 17881361</B></A></td>
|
||
</tr>
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.2.2.2"><B>4.2.2.2</B></A></td>
|
||
<td>Pectate lyase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P0C1A6">PELL_ERWCH</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1RU4"><B>1RU4</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1RU4">Single-stranded right-handed beta-helix</A></td>
|
||
<td center>Polysaccharide lyase family 9</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/14670977"><B>14670977</B></A></td>
|
||
</tr>
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.2.2.2"><B>4.2.2.2</B></A></td>
|
||
<td>Pectate lyase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q47471">Q47471_ERWCA</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=3B4N"><B>3B4N</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1PLU"><I>Single-stranded right-handed beta-helix</I></A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF03211">Pectate lyase (transeliminase)</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/7756691"><B>7756691</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td rowspan=3>92</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.2.2.3"><B>4.2.2.3</B></A></td>
|
||
<td>Poly(<28>-D-mannuronate) lyase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P59786">ALGL_PSEFL</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1QAZ"><I>1QAZ</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1QAZ">Alpha/alpha toroid</A></td>
|
||
<td center>Chondroitin AC/alginate lyase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/12775688"><B>12775688</B></A></td>
|
||
<td rowspan=3>Three distinct structural folds</td></tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.2.2.3"><B>4.2.2.3</B></A></td>
|
||
<td>Poly(<28>-D-mannuronate) lyase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q59478">ALYA_KLEPN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1VAV"><I>1VAV</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1VAV">Concanavalin A-like lectins/glucanases</A></td>
|
||
<td center>Concanavalin A-like lectins/glucanases</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8200539"><B>8200539</B></A></td>
|
||
</tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.2.2.3"><B>4.2.2.3</B></A></td>
|
||
<td>Poly(<28>-D-mannuronate) lyase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q06365">ALYP_PSESO</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1OFM"><I>1OFM</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1OFM">Single-stranded right-handed beta-helix</A></td>
|
||
<td> </td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8336113,8319887"><B>8336113, 8319887</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td rowspan=4>93</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.2.99.18"><B>4.2.99.18</B></A></td>
|
||
<td>DNA-(apurinic or apyrimidinic site) lyase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P0AB83">END3_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2ABK"><B>2ABK</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2ABK">DNA-glycosylase</A></td>
|
||
<td center>Endonuclease III</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2669955"><B>2669955</B></A></td>
|
||
<td rowspan=4>Four distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.2.99.18"><B>4.2.99.18</B></A></td>
|
||
<td>DNA-(apurinic or apyrimidinic site) lyase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P27695">APEX1_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1E9N"><B>1E9N</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1E9N">DNase I-like</A></td>
|
||
<td center>DNase I-like</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1383925,1380694"><B>1383925, 1380694</B></A></td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.2.99.18"><B>4.2.99.18</B></A></td>
|
||
<td>DNA-(apurinic or apyrimidinic site) lyase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P22936">APN1_YEAST</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1QTW"><I>1QTW</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1QTW">TIM beta/alpha barrel</A></td>
|
||
<td center>Endonuclease IV</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/3056935"><B>3056935</B></A></td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.2.99.18"><B>4.2.99.18</B></A></td>
|
||
<td>DNA-(apurinic or apyrimidinic site) lyase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P05523">FPG_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1K82"><B>1K82</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1K82">MutM-like DNA repair proteins</A></td>
|
||
<td center>MutM-like DNA repair proteins</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/11106507,14607836,11912217"><B>11106507, 14607836, 11912217</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td rowspan=4>94</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.6.1.1"><B>4.6.1.1</B></A></td>
|
||
<td>Adenylate cyclase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P00936">CYAA_ECOLI</A></td>
|
||
<td>N/A</td>
|
||
<td>N/A</td>
|
||
<td><A href="http://pfam.xfam.org/family?PF01295"> Adenylate_cyclase class I</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/6344011,92011391"><B>6344011, 92011391</B></A></td>
|
||
<td rowspan=4>Four distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.6.1.1"><B>4.6.1.1</B></A></td>
|
||
<td>Adenylate cyclase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P15318">CYAA_BORPE</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1YRU"><B>1YRU</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1YRU">EF-hand-like</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family?PF03497"> Anthrax toxin LF (class II AC) </A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/2897067,16138079"><B>2897067, 16138079</B></A></td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.6.1.1"><B>4.6.1.1</B></A></td>
|
||
<td>Adenylate cyclase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q08828">CYA1_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1CS4"><B>1CS4</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1CS4">Ferredoxin-like</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family?PF00211"> Adenylate/guanylate cyclase (class III AC)</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8314585"><B>8314585</B></A></td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/4.6.1.1"><B>4.6.1.1</B></A></td>
|
||
<td>Adenylate cyclase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/O69199">O69199_AERHY</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2FJT"><B>2FJT</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2ACA">CYTH-like phosphatases</A></td>
|
||
<td><A href="http://pfam.xfam.org/family?PF01928"> CYTH domain (class IV AC)</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/9642185,16905149"><B>9642185, 16905149</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td rowspan=2>95</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/5.2.1.8"><B>5.2.1.8</B></A></td>
|
||
<td>Peptidylprolyl isomerase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P0AFL3">PPIA_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1CLH"><B>1CLH</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1CLH">Cyclophilin-like</A></td>
|
||
<td center>Cyclophilin</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/9501079,17909185"><B>9501079, 17909185</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/5.2.1.8"><B>5.2.1.8</B></A></td>
|
||
<td>Peptidylprolyl isomerase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P45523">FKBA_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1Q6H"><B>1Q6H</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1Q6H">FKBP-like</A></td>
|
||
<td center>FKBP-type PPIase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1379319"><B>1379319</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td rowspan=3>96</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/5.3.1.8"><B>5.3.1.8</B></A></td>
|
||
<td>Mannose-6-phosphate isomerase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q59935">MANA_STRMU</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1QWR"><B>1QWR</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1QWR">Double-stranded beta-helix</A></td>
|
||
<td center>RmlC-like cupins</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8293960"><B>8293960</B></A></td>
|
||
<td rowspan=3>Three distinct structural folds</td></tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/5.3.1.8"><B>5.3.1.8</B></A></td>
|
||
<td>Mannose-6-phosphate isomerase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P29954">MANA_RHIME</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2GZ6"><I>2GZ6</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2GZ6">Six-hairpin glycosidases</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF07221">GlcNAc 2-epimerase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1452036"><B>1452036</B></A></td>
|
||
</tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/5.3.1.8"><B>5.3.1.8</B></A></td>
|
||
<td>Mannose-6-phosphate isomerase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q4JCA7">PGMI_SULAC</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1TZB"><I>1TZB</I></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1TZB">SIS domain</A></td>
|
||
<td center>SIS_domain</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/14551194"><B>14551194</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td rowspan=2>97</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/5.4.2.1"><B>5.4.2.1</B></A></td>
|
||
<td>Phosphoglycerate mutase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P62707">GPMA_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1E59"><B>1E59</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1E59">Phosphoglycerate mutase</A></td>
|
||
<td center>Phosphoglycerate mutase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/11038361"><B>11038361</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td></tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/5.4.2.1"><B>5.4.2.1</B></A></td>
|
||
<td>Phosphoglycerate mutase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P52832">GPMI_PSESM</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1EJJ"><B>1EJJ</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1EJJ">Alkaline phosphatase-like</A></td>
|
||
<td center>2,3-BPG-independent phosphoglycerate mutase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/12076796"><B>12076796</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td rowspan=2>98</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/5.4.2.8"><B>5.4.2.8</B></A></td>
|
||
<td>Phosphomannomutase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P26405">RFBK_SALTY</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1K2Y"><B>1K2Y</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1K2Y">Phosphoglucomutase</A></td>
|
||
<td center>Phosphoglucomutase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/1710759, 8050998, 11716469, 11839312"><B>PubMed</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td></tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/5.4.2.8"><B>5.4.2.8</B></A></td>
|
||
<td>Phosphomannomutase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/Q92871">PMM1_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2FUC"><B>2FUC</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2FUC">HAD-like</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF03332">Eukaryotic phosphomannomutase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/9119384"><B>9119384</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td rowspan=2>99</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/5.4.99.5"><B>5.4.99.5</B></A></td>
|
||
<td>Chorismate mutase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P42517">CHMU_ENTAG</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2AO2"><B>2AO2</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2AO2">Chorismate mutase II</A></td>
|
||
<td center>Secreted chorismate mutase-like</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8335631,9497350,7496534"><B>8335631, 9497350, 7496534</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td></tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/5.4.99.5"><B>5.4.99.5</B></A></td>
|
||
<td>Chorismate mutase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P19080">CHMU_BACSU</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1COM"><B>1COM</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1COM">Bacillus chorismate mutase-like</A></td>
|
||
<td center>Chorismate mutase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8378335,8046752"><B>8378335, 8046752</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td rowspan=2>100</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/5.5.1.1"><B>5.5.1.1</B></A></td>
|
||
<td>Muconate cycloisomerase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P08310">CATB_PSEPU</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1MUC"><B>1MUC</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1MUC">TIM beta/alpha barrel & Enolase N-terminal domain</A></td>
|
||
<td center>D-glucarate dehydratase-like</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/3609743,3612800"><B>3609743, 3612800</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td>
|
||
</tr>
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/5.5.1.1"><B>5.5.1.1</B></A></td>
|
||
<td>Muconate cycloisomerase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P46057">MLE_TRICU</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1JOF"><B>1JOF</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1JOF">7-bladed beta-propeller</A></td>
|
||
<td center>WD40/YVTN repeat</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/8110801,11937053"><B>8110801, 11937053</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td rowspan=2>101</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/5.99.1.2"><B>5.99.1.2</B></A></td>
|
||
<td>DNA topoisomerase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P06612">TOP1_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1CY1"><B>1CY1</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1CY1">Prokaryotic type I DNA topoisomerase</A></td>
|
||
<td center>Prokaryotic type I DNA topoisomerase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/3029379,8114910,7779808,8622991"><B>PubMed</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td></tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/5.99.1.2"><B>5.99.1.2</B></A></td>
|
||
<td>DNA topoisomerase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P11387">TOP1_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1LPQ"><B>1LPQ</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1LPQ">DNA-breaking-rejoining enzymes</A></td>
|
||
<td center>Eukaryotic DNA topoisomerase I</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/98155246,8747458,16352556"><B>98155246, 8747458, 16352556</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR>
|
||
<td rowspan=2>102</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/6.1.1.6"><B>6.1.1.6</B></A></td>
|
||
<td>Lysine-tRNA ligase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P0A8N3">SYK1_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1BBU"><B>1BBU</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1BBU">Class II aaRS and biotin synthetases</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF00152">Class II aminoacyl-tRNA synthetase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/7735833,11887185"><B>7735833, 11887185</B></A></td>
|
||
<td rowspan=2>Two distinct structural folds</td></tr>
|
||
|
||
<TR>
|
||
<td center><A href="http://enzyme.expasy.org/EC/6.1.1.6"><B>6.1.1.6</B></A></td>
|
||
<td>Lysine-tRNA ligase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/O57963">SYK_PYRHO</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1IRX"><B>1IRX</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1IRX">Adenine nucleotide alpha hydrolase</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF01921">Class I lysyl-tRNA synthetase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/9353192,11887185"><B>9353192, 11887185</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td rowspan=2>103</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/6.1.1.14"><B>6.1.1.14</B></A></td>
|
||
<td>Glycine-tRNA ligase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P00960">SYGA_ECOLI</A> <A href="http://www.uniprot.org/uniprot/P00961">SYGB_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1J5W"><B>1J5W</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1J5W">Class II aaRS and biotin synthetases</A></td>
|
||
<td center>Glycyl-tRNA synthetase, alpha and beta subunits</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/6309809"><B>6309809</B></A></td>
|
||
<td rowspan=2>Same fold, same superfamily, RMSD=2.7 Å over 127 aa</td></tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/6.1.1.14"><B>6.1.1.14</B></A></td>
|
||
<td>Glycine-tRNA ligase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P41250">SYG_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1ATI"><B>1ATI</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1ATI">Class II aaRS and biotin synthetases</A></td>
|
||
<td center>Class-II aminoacyl-tRNA synthetase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/7753621"><B>7753621</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td rowspan=2>104</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/6.3.2.2"><B>6.3.2.2</B></A></td>
|
||
<td>Glutamate-cysteine ligase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P0A6W9">GSH1_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1VA6"><B>1VA6</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1VA6">Glutamine synthetase/ guanido kinase</A></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF04262">Glutamate-cysteine ligase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/86232579"><B>86232579</B></A></td>
|
||
<td rowspan=2>Predicted same fold</td></tr>
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/6.3.2.2"><B>6.3.2.2</B></A></td>
|
||
<td>Glutamate-cysteine ligase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P48506">GSH1_HUMAN</A></td>
|
||
<td center>N/A</td>
|
||
<td center><I>Glutamine synthetase (predicted)</I></td>
|
||
<td center><A href="http://pfam.xfam.org/family/PF03074">Glutamate-cysteine ligase</A></td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/12663448,9675072"><B>12663448, 9675072</B></A></td>
|
||
</tr>
|
||
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td rowspan=2>105</td>
|
||
<td center><A href="http://enzyme.expasy.org/EC/6.3.2.3"><B>6.3.2.3</B></A></td>
|
||
<td>Glutathione synthase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P04425">GSHB_ECOLI</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1GSA"><B>1GSA</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=1GSA">PreATP-grasp domain & ATP-grasp</A></td>
|
||
<td center>Prokaryotic glutathione synthetase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/9010922"><B>9010922</B></A></td>
|
||
<td rowspan=2>Same fold, same superfamily, RMSD=3.5 Å</td></tr>
|
||
|
||
<TR bgColor=#ffff00>
|
||
<td center><A href="http://enzyme.expasy.org/EC/6.3.2.3"><B>6.3.2.3</B></A></td>
|
||
<td>Glutathione synthase</td>
|
||
<td center><A href="http://www.uniprot.org/uniprot/P48637">GSHB_HUMAN</A></td>
|
||
<td center><A href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2HGS"><B>2HGS</B></A></td>
|
||
<td center><A href="http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?ver=1.75&key=2HGS">PreATP-grasp domain & ATP-grasp</A></td>
|
||
<td center>Eukaryotic glutathione synthetase</td>
|
||
<td center><A href="https://www.ncbi.nlm.nih.gov/pubmed/10369661"><B>10369661</B></A></td>
|
||
</tr>
|
||
</TBODY>
|
||
</HTML>
|
||
|
||
|