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<TITLE>Expired NOT-AI-20-031: RESCINDED - Notice of Special Interest (NOSI): Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Coronavirus Disease 2019 (COVID-19)</TITLE>
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<META NAME="description" CONTENT="NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: RESCINDED - Notice of Special Interest (NOSI): Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Coronavirus Disease 2019 (COVID-19) NOT-AI-20-031. NIAID">
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<META NAME="Keywords" CONTENT="NOT-AI-20-031: RESCINDED - Notice of Special Interest (NOSI): Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Coronavirus Disease 2019 (COVID-19)">
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<div class="noticeBar">This notice has been rescinded by <a href="https://grants.nih.gov/grants/guide/notice-files/NOT-AI-20-050.html">NOT-AI-20-050 </a></div>
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<span class="title">RESCINDED - Notice of Special Interest (NOSI): Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Coronavirus Disease 2019 (COVID-19)</span>
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<hr noshade>
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<p><span class="heading3">Notice Number:</span>
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<span class="title">NOT-AI-20-031</span></p>
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<p><span class="heading3">Key Dates</span><br>
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<strong>Release Date:</strong> March 27, 2020<br>
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<strong> First Available Due Date: </strong> April 05, 2020 <br>
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<strong> Expiration Date: </strong> April 05, 2021</p>
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<span class="heading3">Related Announcements</span><br>
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<a href="https://grants.nih.gov/grants/guide/pa-files/PA-19-052.html" target="_blank">PA-19-052</a> NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed)<br>
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<a href="https://grants.nih.gov/grants/guide/pa-files/PA-19-053.html" target="_blank">PA-19-053</a> NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)<br>
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<a href="https://grants.nih.gov/grants/guide/pa-files/PA-18-591.html" target="_blank">PA-18-591</a> Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp - Clinical Trial Optional)<br>
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<a href="https://grants.nih.gov/grants/guide/pa-files/PA-19-056.html" target="_blank">PA-19-056</a> NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)<br>
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<a href="https://grants.nih.gov/grants/guide/pa-files/PA-19-272.html" target="_blank">PA-19-272</a> PHS 2019-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)<br>
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<a href="https://grants.nih.gov/grants/guide/pa-files/PA-19-270.html" target="_blank">PA-19-270</a> PHS 2019-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)<br>
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<a href="https://grants.nih.gov/grants/guide/notice-files/NOT-AI-20-050.html">NOT-AI-20-050 </a>
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<p><span class="heading3">Issued by</span><br>
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National Institute of Allergy and Infectious Diseases (<a href="https://www.niaid.nih.gov/" target="_blank">NIAID</a>)</p>
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<p class="heading2">Purpose</p>
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<div>
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<p>NIAID is issuing this Notice of Special Interest (NOSI) to highlight the need for research on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Coronavirus Disease 2019 (COVID-19). NIAID is particularly interested in projects focusing on viral natural history, pathogenicity, transmission, as well as projects developing medical countermeasures and suitable animal models for pre-clinical testing of vaccines and therapeutics against SARS-CoV-2/COVID-19. NIAID is therefore encouraging applications to address research objectives described below.</p>
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<p><strong>Background</strong></p>
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<p>Coronaviruses are a diverse family of viruses that cause a range of disease in humans and animals, and there are currently no approved coronavirus vaccines or therapeutics. In January 2020, a novel coronavirus was identified as the causative agent of a global pandemic of viral pneumonia. Current information regarding confirmed cases is changing daily and can be found on the Centers for Disease Control and Prevention website (<a href="https://www.cdc.gov/coronavirus/index.html" target="_blank">https://www.cdc.gov/coronavirus/index.html</a>) and through other sources. Transmission characteristics and the associated morbidity and mortality are not completely understood, but there is clear evidence of human-to-human transmission. Many other aspects of viral pathogenesis, natural history, and host range are poorly understood. Given this, there is an urgent public health need to better understand the SARS-CoV-2/COVID-19, particularly to improve understanding of fundamental virology, immunology, and the development of animal models and medical countermeasures.</p>
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<p><strong>Research Objectives</strong></p>
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<p>In order to rapidly improve our understanding and available control measures for SARS-CoV-2 and COVID-19, NIAID is encouraging the submission of applications to address the following research areas of interest:</p>
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<ul>
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<li>Studies to identify optimal <em>in vitro</em> culture requirements and conditions;</li>
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<li>Development of reagents and assays for virus characterization;</li>
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<li>Studies to understand critical aspects of viral infection, replication, pathogenesis, and transmission;</li>
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<li>Studies to identify viral epitopes critical for binding neutralization;</li>
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<li>Studies to examine virus stability and persistence;</li>
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<li>Production of molecular clones of SARS-CoV-2, reporter viruses and recombinant viral proteins;</li>
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<li>Development of animal models of SARS-CoV-2 infection suitable for screening vaccine and therapeutic candidates and/or pathogenesis studies;</li>
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<li>Studies on the evolution and emergence of SARS-CoV-2 viruses including the identification of factors that affect viral host-range and virulence;</li>
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<li>Virologic and serologic surveillance studies of the distribution and natural history of SARS-CoV-2 viruses in animal populations and in humans at the human/animal interface with particular emphasis on host reservoirs and understanding cross-species transmission events;</li>
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<li>Development of sensitive, specific, and rapid clinical diagnostic tests for SARS-CoV-2;</li>
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<li>Development of SARS-COV-2 therapeutic candidates; broad-spectrum therapeutics against multiple coronavirus strains; examination of SARS-CoV-2 antiviral activity of existing or candidate therapeutics initially developed for other indications;</li>
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<li>Identification and evaluation of the innate, cellular and humoral immune responses to SARS-CoV-2 infection and/or candidate vaccines, including, but not limited to: cross-reactive antibodies from individuals exposed to SARS-CoV-2 and other coronaviruses; viral epitopes critical for antibody binding and neutralization; immune-mediated pathology or host factors that might predispose to severe infection; and</li>
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<li>Development of SARS-CoV-2 vaccine candidates that include emerging antigen design strategies, novel platforms or delivery approaches, adjuvants, or assessing cross-neutralization potential of SARS-CoV vaccine candidates.</li>
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</ul>
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</div>
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<div>
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<p><strong><strong>Application and Submission Information</strong></strong></p>
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<p>This notice applies to due dates on or after April 5, 2020 and subsequent receipt dates through April 5, 2021.</p>
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<p>Submit applications for this initiative using one of the following funding opportunity announcements (FOAs) or any reissues of these announcement through the expiration date of this notice:</p>
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<p><a href="https://grants.nih.gov/grants/guide/pa-files/PA-19-052.html" target="_blank">PA-19-052</a> NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed)<br>
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<a href="https://grants.nih.gov/grants/guide/pa-files/PA-19-053.html" target="_blank">PA-19-053</a> - NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)<br>
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<a href="https://grants.nih.gov/grants/guide/pa-files/PA-18-591.html" target="_blank">PA-18-591</a>: Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp - Clinical Trial Optional)<br>
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<a href="https://grants.nih.gov/grants/guide/pa-files/PA-19-056.html" target="_blank">PA-19-056</a> NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)<br>
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<a href="https://grants.nih.gov/grants/guide/pa-files/PA-19-272.html" target="_blank">PA-19-272</a> - PHS 2019-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)<br>
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<a href="https://grants.nih.gov/grants/guide/pa-files/PA-19-270.html" target="_blank">PA-19-270</a> - PHS 2019-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)</p>
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<p>Please note: submissions to <a href="https://grants.nih.gov/grants/guide/pa-files/PA-18-591.html" target="_blank">PA-18-591</a>: Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp - Clinical Trial Optional) will be accepted on a rolling basis effective immediately. Also, the process for Streamlined Submissions using the eRA Commons cannot be used for this initiative. In addition, administrative supplement applications to <a href="https://grants.nih.gov/grants/guide/pa-files/PA-18-591.html" target="_blank">PA-18-591</a> must use the application form package with the Competition ID of FORMS-E-ADMINSUPP-RESEARCH". This FOA will be reissued with a FORMS-F-ADMINSUPP-RESEARCH package on May 25, 2020. Submissions to <a href="https://grants.nih.gov/grants/guide/pa-files/PA-18-591.html" target="_blank">PA-18-591</a> must be completed by June 25, 2020 (see <a href="https://grants.nih.gov/grants/guide/notice-files/NOT-OD-20-026.html" target="_blank">NOT-OD-20-026</a> for details.) Submissions to the reissued FOA will be accepted on or after May 25, 2020 through the expiration date of this Notice.</p>
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<p><strong>All instructions in the <a href="https://grants.nih.gov/grants/how-to-apply-application-guide.html" target="_blank">SF424 (R&R) Application Guide</a> and the funding opportunity announcement used for submission must be followed, with the following additions:</strong></p>
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<p><strong>For funding consideration, applicants must include "NOT-AI-20-031 (without quotation marks) in the Agency Routing Identifier field (box 4B) of the SF424 R&R form. <em>Applications without this information in box 4B will not be considered for this initiative.</em></strong></p>
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</div>
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<div></div>
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<div>Applications nonresponsive to terms of this NOSI will be not be considered for the NOSI initiative.</div>
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<p class="heading2">Inquiries</p>
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<div>Please direct all inquiries to the contacts in Section VII of the listed funding opportunity announcements with the following additions/substitutions:</div>
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<div>
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<p><strong>Scientific/Research Contact(s)</strong></p>
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<p>Erik J. Stemmy, Ph.D.<br>
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Respiratory Diseases Branch<br>
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Division of Microbiology and Infectious Diseases (DMID)<br>
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National Institute of Allergy and Infectious Diseases (NIAID)<br>
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Telephone: 240-627-3380<br>
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Email: <a href="/cdn-cgi/l/email-protection#5336213a387d2027363e3e2a133d3a3b7d343c25"><span class="__cf_email__" data-cfemail="3d584f5456134e49585050447d535455135a524b">[email protected]</span></a></p>
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<p>Wolfgang Leitner, Ph.D.<br>
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Basic Immunology Branch<br>
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Division of Allergy, Immunology, and Transplantation (DAIT)<br>
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National Institute of Allergy and Infectious Diseases (NIAID)<br>
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Telephone: 240-627-3575<br>
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Email: <a href="/cdn-cgi/l/email-protection#691e050c001d070c1b29070008000d47070001470e061f"><span class="__cf_email__" data-cfemail="aed9c2cbc7dac0cbdceec0c7cfc7ca80c0c7c680c9c1d8">[email protected]</span></a></p>
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<p>Martin Gutierrez<br>
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Division of AIDS (DAIDS) <br>
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National Institute of Allergy and Infectious Diseases (NIAID) <br>
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Telephone: 240-292-4844 <br>
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Email: <a href="/cdn-cgi/l/email-protection#b393ded4c6c7dad6c1c1d6c9f3dddad2dad79ddddadb9dd4dcc593"> <span class="__cf_email__" data-cfemail="e9848e9c9d808c9b9b8c93a9878088808dc7878081c78e869f">[email protected]</span> </a> </p>
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