1088 lines
73 KiB
Text
1088 lines
73 KiB
Text
<!DOCTYPE html>
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<html lang="en" dir="ltr">
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<head>
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<meta charset="utf-8" />
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<meta name="description" content="The NIH BRAIN Initiative supports efforts to define, catalogue, map, access and characterize the diverse cell types and their functions in the brain across species. The NIH BRAIN Initiative supports two major transformative consortia with complementary goals: " />
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<title>Tools and Technologies for Brain Cells and Circuits | BRAIN Initiative</title>
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A
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<span class="font-weight-bold">.gov</span>
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website belongs to an official government organization in the United States.
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or
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means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
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src="/themes/custom/brain_bootstrap/assets/images/layout/header/brain_logo.webp"
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sizes="(max-width: 992px) 100px, 800px"
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alt="BRAIN Initiative - Home" />
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</a>
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<img class="float-right d-print-block d-none" alt role="presentation" src="data:image/png;base64,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"/>
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<fieldset class="js-form-item js-form-type-search-api-autocomplete form-type-search-api-autocomplete js-form-item-search-api-fulltext form-item-search-api-fulltext form-group">
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<input placeholder="Search" data-drupal-selector="edit-search-api-fulltext" data-search-api-autocomplete-search="site_search" class="form-autocomplete form-control" data-autocomplete-path="/search_api_autocomplete/site_search?display=page_1&&filter=search_api_fulltext" type="text" id="edit-search-api-fulltext" name="search_api_fulltext" value="" size="30" maxlength="128" />
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<div class="container-fluid">
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<section class="region region-header-form">
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<div class="views-exposed-form block block-views block-views-exposed-filter-blocksite-search-page-2" data-drupal-selector="views-exposed-form-site-search-page-2" id="block-brain-bootstrap-exposedformsite-searchpage-2">
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<div class="content">
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<form block="brain_bootstrap_exposedformsite_searchpage_2" action="/search" method="get" id="views-exposed-form-site-search-page-2" accept-charset="UTF-8" class="form-inline">
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<div class="form-group">
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<fieldset class="js-form-item js-form-type-search-api-autocomplete form-type-search-api-autocomplete js-form-item-search-api-fulltext form-item-search-api-fulltext form-group">
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<label for="edit-search-api-fulltext--2">Search</label>
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<input placeholder="Search" data-drupal-selector="edit-search-api-fulltext" data-search-api-autocomplete-search="site_search" class="form-autocomplete form-control" data-autocomplete-path="/search_api_autocomplete/site_search?display=page_2&&filter=search_api_fulltext" type="text" id="edit-search-api-fulltext--2" name="search_api_fulltext" value="" size="30" maxlength="128" />
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</fieldset>
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<div class="form-group site-search-submit ">
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<button type="submit" class="btn btn-search" aria-label="Submit Search"><i class="fas fa-search"></i></button>
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</div>
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</form>
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</section>
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</div>
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<div class="container">
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<nav role="navigation" aria-labelledby="block-brain-bootstrap-mainnavigation-menu" id="block-brain-bootstrap-mainnavigation" class="block block-menu navigation menu--main">
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<h1 class="title"><span class="field field--name-title field--type-string field--label-hidden">Tools and Technologies for Brain Cells and Circuits</span>
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<div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>The <a href="/glossary?title=NIH" class="glossary-tooltip" data-toggle="tooltip" title="National Institutes of Health - A Federal agency whose mission is to improve the health of the people of the United States. NIH is a part of the Public Health Service, which is part of the U.S. Department of Health and Human Services. ">NIH</a> <a href="/glossary?title=BRAIN" class="glossary-tooltip" data-toggle="tooltip" title="The Brain Research through Advancing Innovative Neurotechnologies Initiative aims to accelerate the development and application of innovate technologies to produce a new, dynamic picture of the brain.">BRAIN</a> Initiative supports efforts to define, catalogue, map, access and characterize the diverse cell types and their functions in the brain across species. The NIH BRAIN Initiative supports two major transformative consortia with complementary goals: </p>
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<p>The <a href="/glossary?title=BRAIN" class="glossary-tooltip" data-toggle="tooltip" title="The Brain Research through Advancing Innovative Neurotechnologies Initiative aims to accelerate the development and application of innovate technologies to produce a new, dynamic picture of the brain.">BRAIN</a> Initiative Cell Atlas Network (BICAN), which builds on findings from the BRAIN Initiative Cell Census Network (BICCN), aims to complete a systematic census and multiscale map of the spatial organization of the neuronal and glial cell types in the brain of multiple species with an emphasis on the human brain. </p>
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<p>The <a href="/glossary?title=BRAIN" class="glossary-tooltip" data-toggle="tooltip" title="The Brain Research through Advancing Innovative Neurotechnologies Initiative aims to accelerate the development and application of innovate technologies to produce a new, dynamic picture of the brain.">BRAIN</a> Initiative Armamentarium for Precision Brain Cell Access, which aims to generate and disseminate a broad array of molecular tools to specifically access, manipulate and monitor brain cell types across species. </p>
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<p>In addition, programs are directed toward (1) developing novel tools for probing specific brain cell types and circuits with greater precision and sensitivity, (2) characterizing understudied cell types such as glia and vascular cells, and (3) improving surrogate experimental assays for human brain function such as organoids. This includes: </p>
|
||
|
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<ul>
|
||
<li>
|
||
<p>Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 <a href="/glossary?title=Clinical+Trial" class="glossary-tooltip" data-toggle="tooltip" title="A research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include placebo or other control) to evaluate the effects of those interventions on health-related biomedical or behavioral outcomes.">Clinical Trial</a> Not Allowed) [<a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-23-290.html">RFA-MH-23-290</a>]. </p>
|
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|
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<p>Development of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in Human and Non-Human Primate Brain (UG3/UH3 <a href="/glossary?title=Clinical+Trial" class="glossary-tooltip" data-toggle="tooltip" title="A research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include placebo or other control) to evaluate the effects of those interventions on health-related biomedical or behavioral outcomes.">Clinical Trial</a> Optional) [<a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-23-295.html">RFA-MH-23-295</a>]. </p>
|
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|
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|
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<p>Tools to target, identify and characterize non-neuronal cells in the brain. </p>
|
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</li>
|
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|
||
<p>Research to Develop and Validate Advanced Human Cell-Based Assays to Model Brain Structure and Function. </p>
|
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|
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|
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|
||
<p>These projects cover developmental and adult stages as well as different physiological states. The ultimate concerted goal of these efforts is to provide both a comprehensive knowledge base and experimental access to diverse brain cell types to enable the study of their roles in health and disease. </p>
|
||
|
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<h2>Programs </h2>
|
||
|
||
<p><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="04093a82-5263-47b4-900d-c4ed750ae036" href="/research/tools-and-technologies-brain-cells-and-circuits/brain-initiative-cell-census-network">The BRAIN Initiative Cell Census Network (BICCN) </a> </p>
|
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|
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<p><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="b63e43d3-4a83-4ae0-96ec-f66cfe0b4f8d" href="/research/tools-and-technologies-brain-cells-and-circuits/brain-initiative-cell-atlas-network">The BRAIN Initiative Cell Atlas Network (BICAN)</a></p>
|
||
|
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<p><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="4844df8a-0129-4b58-805b-92fc8f52c968" href="/research/tools-and-technologies-brain-cells-and-circuits/armamentarium-precision-brain-cell-access">The BRAIN Initiative Armamentarium for Precision Brain Cell Acces</a>s </p>
|
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|
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<p> </p>
|
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<h2>Related Information </h2>
|
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<p><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="96c5a4c2-0324-472d-850a-ba096272d604" href="/vision/transformative-projects">The NIH BRAIN Initiative Transformative Projects</a> </p>
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<p> </p>
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<h2>Contact</h2>
|
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<p>For questions related to funding opportunities or program areas, please find contact information below. For public inquiries, please use our <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="1a80e506-f7bd-42fa-b7c5-d3cb197efc1d" href="/about/contact-us">Contact Us</a> form.</p>
|
||
|
||
<p><strong>Olivier Berton, Ph.D.</strong><br>
|
||
National Institute on Drug Abuse (<a href="/glossary?title=NIDA" class="glossary-tooltip" data-toggle="tooltip" title="NIH National Institute on Drug Abuse">NIDA</a>)<br>
|
||
<a href="mailto:olivier.berton@nih.gov">olivier.berton@nih.gov</a></p>
|
||
|
||
<p><strong>David Panchision, Ph.D.</strong><br>
|
||
National Institutes of Mental Health (<a href="/glossary?title=NIMH" class="glossary-tooltip" data-toggle="tooltip" title="NIH National Institute of Mental Health">NIMH</a>)<br>
|
||
<a href="mailto:panchisiond@mail.nih.gov">panchisiond@mail.nih.gov</a> </p></div>
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