984 lines
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<meta name="description" content="NIH BRAIN Initiative grantee Lihong Wang receives award for the development of innovative brain imaging technology. Lihong Wang, biomedical engineer at Washington University in St. Louis and NIH BRAIN Initiative grantee, was awarded the 2015 Britton Chance Biomedical Optics Award earlier this year by SPIE (the international society for optics and photonics) for his pioneering work towards the development and application of new imaging techniques." />
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<h1 class="title"><span class="field field--name-title field--type-string field--label-hidden">BRAIN Initiative grantee receives prestigious biomedical optics and imaging award</span>
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<div class="field field--name-field-simple-date field--type-datetime field--label-hidden field__item"><time datetime="2015-08-07T12:00:00Z" class="datetime">August 07, 2015</time>
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<source srcset="/sites/default/files/styles/half_width_large/public/migrate-images/image-2_3.png?itok=cVwIg9Q0 1x" media="all and (min-width: 62em) and (max-width: 74.99em)" type="image/png" width="256" height="156"/>
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<source srcset="/sites/default/files/styles/half_width_medium/public/migrate-images/image-2_3.png?itok=UPjLDXbq 1x" media="all and (min-width: 48em) and (max-width: 61.99em)" type="image/png" width="240" height="146"/>
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<source srcset="/sites/default/files/styles/half_width_small/public/migrate-images/image-2_3.png?itok=CIpVNSai 1x" media="all and (min-width: 34em) and (max-width: 47.99em)" type="image/png" width="220" height="134"/>
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<div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p><em>NIH BRAIN Initiative grantee Lihong Wang receives award for the development of innovative brain imaging technology. </em></p>
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||
<p><a href="http://oilab.seas.wustl.edu/index.html">Lihong Wang</a>, biomedical engineer at Washington University in St. Louis and <a href="/glossary?title=NIH" class="glossary-tooltip" data-toggle="tooltip" title="National Institutes of Health - A Federal agency whose mission is to improve the health of the people of the United States. NIH is a part of the Public Health Service, which is part of the U.S. Department of Health and Human Services. ">NIH</a> <a href="/glossary?title=BRAIN" class="glossary-tooltip" data-toggle="tooltip" title="The Brain Research through Advancing Innovative Neurotechnologies Initiative aims to accelerate the development and application of innovate technologies to produce a new, dynamic picture of the brain.">BRAIN</a> Initiative grantee, was <a href="http://spie.org/x110605.xml">awarded</a> the 2015 Britton Chance Biomedical Optics Award earlier this year by SPIE (the international society for optics and photonics) for his pioneering work towards the development and application of new imaging techniques.</p>
|
||
|
||
<p>In May, Dr. Wang and his colleagues published a Nature Methods <a href="http://www.ncbi.nlm.nih.gov/pubmed/25822799">paper</a> describing photoacoustic microscopy—a variation on ultrasound imaging that uses pressure waves to measure biological structures and functions.</p>
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<source srcset="/sites/default/files/styles/full_width_/public/brain_blog_media/image/retina-eye_cropped.gif?itok=2KWyRZdy 1x" media="all and (min-width: 62em) and (max-width: 74.99em)" type="image/gif" width="392" height="392">
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<source srcset="/sites/default/files/styles/full_width_medium/public/brain_blog_media/image/retina-eye_cropped.gif?itok=OJN-c5U3 1x" media="all and (min-width: 48em) and (max-width: 61.99em)" type="image/gif" width="392" height="392">
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<source srcset="/sites/default/files/styles/full_width_small/public/brain_blog_media/image/retina-eye_cropped.gif?itok=JiQf0rva 1x" media="all and (min-width: 34em) and (max-width: 47.99em)" type="image/gif" width="392" height="392">
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<img loading="eager" src="/sites/default/files/styles/full_width_small/public/brain_blog_media/image/retina-eye_cropped.gif?itok=JiQf0rva" width="392" height="392" alt="Photoacoustic microscopy reveals the detailed structure of blood vessels in the iris of a mouse eye. Source: Lihong Wang/Optical Imaging Laboratory/Washington University">
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||
<figcaption>Photoacoustic microscopy reveals the detailed structure of blood vessels in the iris of a mouse eye.<br>
|
||
<em>Source: Lihong Wang/Optical Imaging Laboratory/Washington University</em></figcaption>
|
||
</figure>
|
||
<p>Dr. Wang and his group demonstrated the usefulness of this non-invasive technology to perform high-speed, high-resolution imaging of the structure of blood vessels, blood oxygenation levels, blood flow dynamics, and oxygen metabolism of the mouse brain at rest and when electrically stimulated. Photoacoustic microscopy offers several advantages over other imaging techniques commonly used to study the vasculature system of the brain (such as 2-photon microscopy, wide-field optical microscopy, and fMRI), including fast blood oxygenation imaging and fine spatial resolution for defining blood vessel structure. Studying these features of the brain’s vasculature system can provide insight into brain function and the development of diseases such as diabetes and cancer. NPR <a href="http://www.npr.org/sections/health-shots/2015/07/27/425068015/a-scientist-deploys-light-and-sound-to-reveal-the-brain">recently published a story</a> about the potential of this remarkable technique. </p>
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<img loading="eager" src="/sites/default/files/styles/full_width_small/public/brain_blog_media/image/brain_vasculature.png?itok=kvqWu5G0" width="300" height="265" alt="Brain vasculature imaged through intact mouse skull (left). Oxygen saturation levels of hemoglobin measured with photoacoustic microscopy (right). Source: doi:10.1038/nmeth.3336">
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<figcaption>Brain vasculature imaged through intact mouse skull (left). Oxygen saturation levels of hemoglobin measured with photoacoustic microscopy (right).<br>
|
||
<em>Source: doi:10.1038/nmeth.3336</em></figcaption>
|
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</figure>
|
||
<p>A technique closely related to photoacoustic microscopy called photoacoustic tomography is the focus of Dr. Wang’s <a href="/glossary?title=NIH" class="glossary-tooltip" data-toggle="tooltip" title="National Institutes of Health - A Federal agency whose mission is to improve the health of the people of the United States. NIH is a part of the Public Health Service, which is part of the U.S. Department of Health and Human Services. ">NIH</a> <a href="/glossary?title=BRAIN" class="glossary-tooltip" data-toggle="tooltip" title="The Brain Research through Advancing Innovative Neurotechnologies Initiative aims to accelerate the development and application of innovate technologies to produce a new, dynamic picture of the brain.">BRAIN</a> Initiative <a href="http://projectreporter.nih.gov/project_info_description.cfm?icde=0&aid=8827138">grant</a> in FY 2104. Dr. Wang originally invented photoacoustic tomography (PAT) to detect cancer, but for his <a href="/glossary?title=BRAIN" class="glossary-tooltip" data-toggle="tooltip" title="The Brain Research through Advancing Innovative Neurotechnologies Initiative aims to accelerate the development and application of innovate technologies to produce a new, dynamic picture of the brain.">BRAIN</a> Initiative grant he has applied the technique to measure the action potentials of large groups of individual neurons. During an action potential, molecules genetically expressed by specific subpopulations of neurons can absorb light, causing them to heat up and release pressure waves that are detected by a device outside the brain and then converted into images of the neuron’s activity. PAT confers several advantages over current techniques for measuring neural activity: it is non-invasive; targets defined subpopulations of neurons; and because brain tissue minimally scatters pressure waves, it can be used for deep penetration to facilitate measurements of whole brain activity. </p></div>
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