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<meta name="description" content="The BRAIN Initiative is marking a milestone—10 years of advancing neuroscience and neurotechnology research by funding innovative projects. As part of a rotating series of blog posts, the directors of the BRAIN Initiative-partnering Institutes and Centers share their voice and perspectives on the impact BRAIN has made on their respective missions—and vice versa. By Bruce J. Tromberg, Ph.D., Director, National Institute of Biomedical Imaging and Bioengineering " />
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<title>BRAIN at 10: A View from the National Institute of Biomedical Imaging and Bioengineering | BRAIN Initiative</title>
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<h1 class="title"><span class="field field--name-title field--type-string field--label-hidden">BRAIN at 10: A View from the National Institute of Biomedical Imaging and Bioengineering </span>
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<div class="field field--name-field-simple-date field--type-datetime field--label-hidden field__item"><time datetime="2024-11-19T12:00:00Z" class="datetime">November 19, 2024</time>
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<div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div><p><em>The BRAIN Initiative is marking a milestone—10 years of advancing neuroscience and neurotechnology research by funding innovative projects. As part of a rotating series of blog posts, the directors of the BRAIN Initiative-partnering Institutes and Centers share their voice and perspectives on the impact BRAIN has made on their respective missions—and vice versa.</em> </p></div><div><p><em>By Bruce J. Tromberg, Ph.D., Director, National Institute of Biomedical Imaging and Bioengineering</em> </p><p><strong>How does NIBIB’s mission align with the NIH BRAIN Initiative?</strong> </p><p><a href="https://braininitiative.nih.gov/glossary?title=NIBIB">NIBIB</a>’s mission is to transform, through technology development, our understanding of disease and its prevention, detection, diagnosis, and treatment. It is synergistic with the <a href="https://braininitiative.nih.gov/glossary?title=BRAIN">BRAIN</a> Initiative mission—to accelerate the development of innovative neurotechnologies and revolutionize our understanding of the human brain. <a href="https://braininitiative.nih.gov/glossary?title=NIBIB">NIBIB</a> is a key technology development hub at <a href="https://braininitiative.nih.gov/glossary?title=NIH">NIH</a>, and for the past decade we have collaborated with the <a href="https://braininitiative.nih.gov/glossary?title=BRAIN">BRAIN</a> Initiative to support development of technologies enabling breakthrough discoveries about the human brain’s structure and function. Our extramural program staff have led <a href="/glossary?title=BRAIN" class="glossary-tooltip" data-toggle="tooltip" title="The Brain Research through Advancing Innovative Neurotechnologies Initiative aims to accelerate the development and application of innovate technologies to produce a new, dynamic picture of the brain.">BRAIN</a> Initiative planning, implementation, and oversight of numerous BRAIN programs and activities. As a result, new scanners, methodologies, and approaches have dramatically improved existing imaging capabilities. </p><p>The <a href="https://braininitiative.nih.gov/glossary?title=BRAIN">BRAIN</a> Initiative emerged in April 2013 from a <a href="https://obamawhitehouse.archives.gov/blog/2013/04/02/brain-initiative-challenges-researchers-unlock-mysteries-human-mind">U.S. Presidential directive</a> to move neuroscience into a new era of identifying and tracking neural networks. To achieve that goal, <a href="https://braininitiative.nih.gov/glossary?title=NIBIB">NIBIB</a> launched and led the Foundations of Non-Invasive Functional Human Brain Imaging program: Bridging Scales and Modalities. This program has supported the development of various non-invasive neuroimaging tools. These include a high-field MRI scanner that improves spatial resolution by an order of magnitude, a dedicated brain PET scanner that is 10-fold more sensitive than current machines, and a wearable high-density functional near-infrared spectroscopy (fNIRS) system to measure brain function in real-time during natural behaviors. </p></div><div><p><strong>How has NIBIB participated in the NIH BRAIN Initiative? </strong> </p><p><a href="https://braininitiative.nih.gov/glossary?title=NIBIB">NIBIB</a>’s scientific and programmatic expertise as part of the <a href="https://braininitiative.nih.gov/glossary?title=BRAIN">BRAIN</a> Initiative early on was instrumental in the launch of next-generation human brain imaging modalities, as well as for stimulating the development of theories, mechanistic models, and analytical tools to understand brain circuits at various scales from cells to whole organisms. A long-time supporter of team science and model-driven experimental design, <a href="https://braininitiative.nih.gov/glossary?title=NIBIB">NIBIB</a> has <a href="https://www.cell.com/neuron/fulltext/S0896-6273(20)30898-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627320308989%3Fshowall%3Dtrue">facilitated culture change in neuroscience</a>: a lasting legacy of the <a href="https://braininitiative.nih.gov/glossary?title=BRAIN">BRAIN</a> Initiative. </p><p><a href="https://braininitiative.nih.gov/glossary?title=NIBIB">NIBIB</a> and the <a href="https://braininitiative.nih.gov/glossary?title=BRAIN">BRAIN</a> Initiative also share a commitment to training and workforce development, demonstrated by <a href="https://braininitiative.nih.gov/glossary?title=NIBIB">NIBIB</a>’s support of all <a href="/glossary?title=BRAIN" class="glossary-tooltip" data-toggle="tooltip" title="The Brain Research through Advancing Innovative Neurotechnologies Initiative aims to accelerate the development and application of innovate technologies to produce a new, dynamic picture of the brain.">BRAIN</a> training and career development activities, including participation and applications from individuals from underrepresented and minority groups. In particular, the <a href="https://braininitiative.nih.gov/research/training-inclusion-and-equity/k99-r00-awardees">BRAIN’s Pathway to Independence program</a> has supported promising research scientists toward launching successful careers. Both NIBIB-supported scientists part of this program are women, and one has made the transition to tenure track and received her first <a href="https://grants.nih.gov/funding/activity-codes/R01">NIH R01 grant</a>: a major milestone for career independence. </p><p><strong>What major BRAIN-funded scientific advancements or conversations has NIBIB been a part of?</strong> </p><p><a href="https://braininitiative.nih.gov/glossary?title=NIBIB">NIBIB</a> researchers are a multidisciplinary community with experience in team-based problem solving. <a href="/glossary?title=NIBIB" class="glossary-tooltip" data-toggle="tooltip" title="NIH National Institute of Biomedical Imaging and Bioengineering">NIBIB</a> was an early advocate in <a href="https://braininitiative.nih.gov/glossary?title=BRAIN">BRAIN</a>’s-support of the multidisciplinary nature of the <a href="/glossary?title=BRAIN" class="glossary-tooltip" data-toggle="tooltip" title="The Brain Research through Advancing Innovative Neurotechnologies Initiative aims to accelerate the development and application of innovate technologies to produce a new, dynamic picture of the brain.">BRAIN</a> investigative teams, particularly by recruiting investigators from physical sciences and engineering to work alongside biologists, neuroscientists, and clinical and behavioral scientists. <a href="https://braininitiative.nih.gov/glossary?title=NIBIB">NIBIB</a> is a committed advocate of the value of diverse expertise, facilitating strong academic-industry partnerships. </p><p>In one noteworthy example of a collaboration between Yale University, the University of California, Davis, and United Imaging Healthcare of America, <a href="https://braininitiative.nih.gov/glossary?title=NIBIB">NIBIB</a> grantees with <a href="https://braininitiative.nih.gov/glossary?title=BRAIN">BRAIN</a> Initiative support developed the NeuroEXPLORER scanner to produce high-resolution PET images of the human brain with exceptional sensitivity. As such, scientists can make direct measurements of brain nuclei never before possible. Although still currently a research tool, its developers anticipate that the technology will become available for clinical use. </p><p><strong>Why do you think it’s important for NIBIB to participate in the NIH BRAIN Initiative? </strong> </p><p>Both <a href="https://braininitiative.nih.gov/glossary?title=NIBIB">NIBIB</a> and the <a href="https://braininitiative.nih.gov/glossary?title=BRAIN">BRAIN</a> Initiative are committed to developing and sharing innovative technology, leveraging activities and sharing lessons learned. Developing disease-agnostic tools to interact with, and better understand, the nervous system will have wide-ranging (and as-yet unpredictable) impacts across the biomedical research spectrum. Dramatic improvements in MRI provide a clear example: initially developed to visualize soft tissue contrast in the body, MRI technology has rapidly evolved as a powerful tool to measure brain activity (fMRI), and to map white matter structure in the brain (diffusion MRI/tractography). </p><p><strong>How has the BRAIN Initiative advanced or shaped your mission? </strong> </p><p>The <a href="https://braininitiative.nih.gov/glossary?title=BRAIN">BRAIN</a> Initiative has supported the <a href="https://braininitiative.nih.gov/glossary?title=NIBIB">NIBIB</a> mission by supercharging investments in neurotechnologies. The Initiative has also shown that scientific culture change is possible, providing partners, like us, an important avenue for pushing hard to accomplish tasks through technology innovation. </p><p>In a fundamental way, the <a href="https://braininitiative.nih.gov/glossary?title=BRAIN">BRAIN</a> Initiative has galvanized the neuroimaging, neuromodeling and neurotechnology communities. We look forward to more game-changing advances that will revolutionize our understanding of the human brain—the vision of the <a href="/glossary?title=BRAIN" class="glossary-tooltip" data-toggle="tooltip" title="The Brain Research through Advancing Innovative Neurotechnologies Initiative aims to accelerate the development and application of innovate technologies to produce a new, dynamic picture of the brain.">BRAIN</a> Initiative. </p></div></div>
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