nih-gov/www.braininitiative.nih.gov/funding/funding-opportunities/open.json?page&_format=json

[{"title":"BRAIN Initiative: New Concepts and Early-Stage Research for Recording and Modulation in the Nervous System (R21) (Clinical Trial Not Allowed)","field_funding_opp_number":"RFA-EY-25-001","field_external_link":"http:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/RFA-EY-25-001.html","field_funding_opp_status":"Open","field_expiration_date":"\u003Ctime datetime=\u00222026-06-16T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2026-06-16\u003C\/time\u003E\n","body":"A central goal of the BRAIN Initiative is to understand how electrical and chemical signals code information in neural circuits and give rise to sensations, thoughts, emotions and actions. While currently available technologies can provide some understanding, they may not be sufficient to accomplish this goal. For example, non-invasive technologies are low resolution and\/or provide indirect measures such as blood flow, which are imprecise; invasive technologies can provide information at the level of single neurons producing the fundamental biophysical signals, but they can only be applied to tens or hundreds of neurons, out of a total number in the human brain estimated at 85 billion.\nOther BRAIN FOAs seek to develop novel technology (RFA-NS-17-003) or to optimize existing technology ready for in-vivo proof-of-concept testing and collection of preliminary data (RFA-NS-17-004) for recording or manipulating neural activity on a scale that is beyond what is currently possible. This FOA seeks applications for unique and innovative technologies that are in an even earlier stage of development than that sought in other FOAs, including new and untested ideas that are in the initial stages of conceptualization.\nIn addition to experimental approaches, the support provided under this FOA might enable calculations, simulations, computational models, or other mathematical techniques for demonstrating that the signal sources and\/or measurement technologies are theoretically capable of meeting the demands of large-scale recording or manipulation of circuit activity in humans or in animal models. The support might also be used for building and testing phantoms, prototypes, in-vitro or other bench-top models in order to validate underlying theoretical assumptions in preparation for future FOAs aimed at testing in animal models.","field_grant_mechanism":"Research Projects","field_priority_area":"","field_program":"","field_research_area":""},{"title":"BRAIN Initiative: Promoting Equity Through BRAIN Technology Partnerships (R34 - Clinical Trials Not Allowed)","field_funding_opp_number":"RFA-NS-25-016","field_external_link":"http:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/RFA-NS-25-016.html","field_funding_opp_status":"Open","field_expiration_date":"\u003Ctime datetime=\u00222026-06-18T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2026-06-18\u003C\/time\u003E\n","body":"The goal of this concept is to increase the impact of the BRAIN Initiative by targeted dissemination and integration of validated BRAIN Initiative tools to investigators at institutions that historically have not been major recipients of NIH support. This will be accomplished by awards to PIs at resource-limited institutions (RLIs) who pair with BRAIN technologists to facilitate training and adoption of BRAIN Initiative technologies in the recipient laboratories. Goals include two-way knowledge transfer between the PI and BRAIN technologist and to increase the participation of PIs at RLIs in BRAIN Initiative relevant research.","field_grant_mechanism":"Research Projects","field_priority_area":"","field_program":"","field_research_area":""},{"title":"BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed)","field_funding_opp_number":"RFA-MH-26-170","field_external_link":"http:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/RFA-MH-26-170.html","field_funding_opp_status":"Open","field_expiration_date":"\u003Ctime datetime=\u00222027-02-09T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2027-02-09\u003C\/time\u003E\n","body":"The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function. The new tools and technologies should inform and\/or exploit cell-type and\/or circuit-level specificity. Plans for validating the utility of the tool\/technology will be an essential feature of a successful application. The development of new genetic and non-genetic tools for delivering genes, proteins and chemicals to cells of interest or approaches that are expected to target specific cell types and\/or circuits in the nervous system with greater precision and sensitivity than currently established methods are encouraged. Tools that can be used in a number of species\/model organisms rather than those restricted to a single species are highly desired. Applications that provide approaches that break through existing technical barriers to substantially improve current capabilities are highly encouraged.","field_grant_mechanism":"Research Projects","field_priority_area":"","field_program":"","field_research_area":""},{"title":"BRAIN Initiative: Clinical Studies to Advance Next-Generation Devices for Recording and Modulation in the Human Central Nervous System (UH3 Clinical Trial Optional)","field_funding_opp_number":"RFA-NS-25-022","field_external_link":"http:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/RFA-NS-25-022.html","field_funding_opp_status":"Open","field_expiration_date":"\u003Ctime datetime=\u00222026-09-29T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2026-09-29\u003C\/time\u003E\n","body":"The purpose of this announcement is to encourage investigators to pursue a small clinical trial to obtain critical information necessary to advance recording and\/or stimulating devices to treat central nervous system disorders and better understand the human brain (e.g., Early Feasibility Study).  Clinical studies supported may consist of acute or short-term procedures that are deemed Non-Significant Risk (NSR) by an Institutional Review Board (IRB), or Significant Risk (SR) studies that require an Investigational Device Exemption (IDE) from the FDA, such as chronic implants.  The clinical trial should provide data to answer key questions about the function or final design of a device.  This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval.  The clinical trial is expected to provide information that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. Activities supported by this Funding Opportunity include a small clinical trial to answer key questions about the function or final design of a device.\nAs part of the BRAIN Initiative, NIH has initiated a Public-Private Partnership Program (BRAIN PPP) that includes agreements (Memoranda of Understanding, MOU) with a number of device manufacturers willing to make such devices available, including devices and capabilities not yet market approved but appropriate for clinical research.  In general it is expected that the devices\u0027 existing safety and utility data will be sufficient to enable new IRB NSR or FDA IDE approval without need for significant additional non-clinical data. \nFor more information on the BRAIN PPP, see \u003Ca href=\u0022http:\/\/braininitiative.nih.gov\/BRAIN_PPP\/index.htm\u0022\u003Ehttp:\/\/braininitiative.nih.gov\/BRAIN_PPP\/index.htm\u003C\/a\u003E","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"","field_program":"","field_research_area":""},{"title":"BRAIN Initiative:  Next-Generation Devices for Recording and Modulation in the Human Central Nervous System (UG3\/UH3 Clinical Trial Optional)","field_funding_opp_number":"RFA-NS-25-021","field_external_link":"http:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/RFA-NS-25-021.html","field_funding_opp_status":"Open","field_expiration_date":"\u003Ctime datetime=\u00222026-09-29T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2026-09-29\u003C\/time\u003E\n","body":"The purpose of this announcement is to encourage investigators to pursue translational activities and small clinical studies to advance the development of therapeutic, and diagnostic devices for disorders that affect the nervous or neuromuscular systems. Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, obtaining an Investigational Device Exemption (IDE) for a Significant Risk (SR) study, as well as a subsequent small clinical study. The clinical study is expected to provide information about the device function or final design that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. This FOA is a milestone-driven cooperative agreement program and will involve participation of NIH program staff in negotiating the final project plan before award and monitoring of research progress.","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"","field_program":"","field_research_area":""},{"title":"BRAIN Initiative: Brain Behavior Quantification and Synchronization- Next Generation Sensor Technology Development (U01 Clinical Trial Optional)","field_funding_opp_number":"RFA-MH-26-140","field_external_link":"http:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/RFA-MH-26-140.html","field_funding_opp_status":"Open","field_expiration_date":"\u003Ctime datetime=\u00222027-06-16T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2027-06-16\u003C\/time\u003E\n","body":"This NOFO solicits applications for next generation sensor and bioelectronic device development that will synchronize with brain recordings. The sensor and neural recording data will be used to generate new computational models of behavior in human and animal models. There has been a lack of quantitative approaches and models to understand the complexity of human and animal behavior in naturalistic settings. This NOFO focuses on the development of next generation sensors to acquire data and synchronize it with simultaneous brain recordings to build computational models.","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"","field_program":"","field_research_area":""},{"title":"BRAIN Initiative: Reagent Resources for Brain Cell Type-Specific Access to Broaden Distribution of Enabling Technologies for Neuroscience (U24 Clinical Trial Not Allowed)","field_funding_opp_number":"RFA-MH-26-120","field_external_link":"http:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/RFA-MH-26-120.html","field_funding_opp_status":"Open","field_expiration_date":"\u003Ctime datetime=\u00222027-06-16T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2027-06-16\u003C\/time\u003E\n","body":"This Notice of Funding Opportunity Announcement (NOFO) from the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is intended to support establishment of facilities at minority-serving institutions (MSIs) and Institutional Development Award (IDeA)-eligible institutions for scaled production and distribution of brain cell type-specific access and manipulation reagents. Reagents will be initially developed in pilot resource projects for brain cell type-specific access and manipulation across vertebrate species from the BRAIN Initiative Armamentarium project. Awardees under this NOFO will work with the other Armamentarium awardees to manufacture and distribute the resources for use throughout the neuroscience community. It is envisioned that the awardees will work both with the Armamentarium community as well as with the neuroscience research community to optimize the use of new reagents. The types of reagents to be produced and distributed could include but are not limited to viral vectors, nucleic acid constructs, and nanoparticles designed for selective access to and manipulation of brain cell types. Such reagents will enable neuroscientists to probe circuit function with high precision in experimental animals and ex vivo human tissue and cells. Facilities are needed to contribute to the production and distribution of BRAIN Initiative Armamentarium project reagents broadly to neuroscience users.","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"","field_program":"","field_research_area":""},{"title":"BRAIN Initiative: New Technologies and Novel Approaches for Recording and Modulation in the Nervous System (R01 Clinical Trial Not Allowed)","field_funding_opp_number":"RFA-NS-25-018","field_external_link":"http:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/RFA-NS-25-018.html","field_funding_opp_status":"Open","field_expiration_date":"\u003Ctime datetime=\u00222026-01-21T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2026-01-21\u003C\/time\u003E\n","body":"Understanding the dynamic activity of brain circuits is central to the NIH BRAIN Initiative.  This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for recording and modulation (including various modalities for stimulation\/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS).  This FOA seeks exceptionally creative approaches to address major challenges associated with recording and modulating CNS activity, at or near cellular resolution, at multiple spatial and\/or temporal scales, in any region and throughout the entire depth of the brain.  It is expected that the proposed research may be high-risk, but if successful, could profoundly change the course of neuroscience research. \nProposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS.  Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, magnetic, acoustic and\/or genetic recording\/manipulation.  Applications that seek to integrate multiple approaches are encouraged.  If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.","field_grant_mechanism":"Research Projects","field_priority_area":"","field_program":"","field_research_area":""},{"title":"BRAIN Initiative: Optimization of Instrumentation and Device Technologies for Recording and Modulation in the Nervous System (U01 Clinical Trials Not Allowed)","field_funding_opp_number":"RFA-NS-25-017","field_external_link":"http:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/RFA-NS-25-017.html","field_funding_opp_status":"Open","field_expiration_date":"\u003Ctime datetime=\u00222026-01-21T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2026-01-21\u003C\/time\u003E\n","body":"Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative. The invention, proof-of-concept investigation, and optimization of new technologies through iterative feedback from end users are key components of the BRAIN Initiative. This FOA seeks applications to optimize existing or emerging technologies through iterative testing with end users. The technologies and approaches should have potential to address major challenges associated with recording and modulation (including various modalities for stimulation\/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS).  These technologies and approaches should have previously demonstrated their transformative potential through initial proof-of-concept testing and are now ready for accelerated refinement. In conjunction, the manufacturing techniques should be scalable towards sustainable, broad dissemination and user-friendly incorporation into regular neuroscience research.\nProposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS.  Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, electrical, magnetic, acoustic or genetic recording\/manipulation.  Applications that seek to integrate multiple approaches are encouraged.  If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"","field_program":"","field_research_area":""},{"title":"BRAIN Initiative: Brain-Behavior Quantification and Synchronization  Transformative and Integrative Models of Behavior at the Organismal Level (U01 Clinical Trials Not Allowed)","field_funding_opp_number":"RFA-DA-24-041","field_external_link":"http:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/RFA-DA-24-041.html","field_funding_opp_status":"Open","field_expiration_date":"\u003Ctime datetime=\u00222026-10-10T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2026-10-10\u003C\/time\u003E\n","body":"\u003Cp\u003EThis Brain-Behavior Quantification and Synchronization notice of funding opportunity (NOFO) seeks applications proposing research aiming to 1) develop, validate, and apply cutting-edge tools and methods for minimally invasive, multi-dimensional, high-resolution measurement of behavior at the organismal level, with synchronous capture of changes in the organisms social or physical environment; and 2) develop computational methods that allow for integration of multidimensional behavioral and environmental data representing multiple timescales into a conceptual and\/or computational model of behavior as a complex dynamic system. Proposed projects are also expected to be designed with the capacity to integrate synchronously recorded neural data and\/or inform existing models of neurobehavioral function, such as those developed with the support of the NIH BRAIN Initiative. Research that falls under the definition of an NIH Clinical Trial is not allowed under this NOFO. Applicants interested in proposing mechanistic research in humans relevant to the above purpose should submit under the companion U01 NOFO, RFA-DA-24-040. This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn. Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.\u003C\/p\u003E","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"BBQS, Understanding Circuits","field_research_area":"Systems Neuroscience"},{"title":"BRAIN Initiative: Brain-Behavior Quantification and Synchronization  Transformative and Integrative Models of Behavior at the Organismal Level (U01 Clinical Trial Optional)","field_funding_opp_number":"RFA-DA-24-040","field_external_link":"http:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/RFA-DA-24-040.html","field_funding_opp_status":"Open","field_expiration_date":"\u003Ctime datetime=\u00222026-10-10T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2026-10-10\u003C\/time\u003E\n","body":"\u003Cp\u003EThis Brain-Behavior Quantification and Synchronization notice of funding opportunity (NOFO) seeks applications that bring together transdisciplinary teams and aim to 1) develop, validate, and apply cutting-edge tools and methods for minimally invasive, multi-dimensional, high-resolution objective measurement of behavior at the organismal level, with synchronous capture of dynamic environmental data; 2) develop advanced analytic approaches to integrate multidimensional behavioral, neural and environmental data; and 3) develop and test new theoretical and computational models aiming to advance understanding of behavior as a complex dynamic system. Proposed projects are expected to be designed with the capacity to integrate synchronously recorded neural data and\/or inform existing models of neurobehavioral function, such as those developed with the support of the NIH BRAIN Initiative. This BRAIN Initiative NOFO is specifically soliciting applications proposing basic research involving human subjects aiming to reveal and understand fundamental principles underlying behavioral function, including research limited to observational studies or analysis of human data. Applications proposing research using exclusively non-human animal models should apply under the companion NOFO, RFA-DA-24-041. This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP).\u003C\/p\u003E","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Integrated Approaches, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"BBQS, Understanding Circuits","field_research_area":"Human Neuroscience, Systems Neuroscience"},{"title":"BRAIN Initiative:  Next-Generation Devices for Recording and Modulation in the Human Central Nervous System (UG3\/UH3 Clinical Trial Optional)","field_funding_opp_number":"RFA-NS-24-016","field_external_link":"http:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/RFA-NS-24-016.html","field_funding_opp_status":"Open","field_expiration_date":"\u003Ctime datetime=\u00222027-01-29T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2027-01-29\u003C\/time\u003E\n","body":"\u003Cp\u003EReissue: RFA-NS-21-023 - The purpose of this Funding Opportunity Announcement (FOA) is to encourage investigators to pursue translational activities and small clinical studies to advance the development of therapeutic, and diagnostic devices for disorders that affect the nervous or neuromuscular systems. Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, obtaining an Investigational Device Exemption (IDE) for a Significant Risk (SR) study, as well as a subsequent small clinical study. The clinical study is expected to provide information about the device function or final design that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. This FOA is a milestone-driven cooperative agreement program and will involve participation of NIH program staff in negotiating the final project plan before award and monitoring of research progress.\u003C\/p\u003E","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation"},{"title":"BRAIN Initiative: Preclinical Proof of Concept for Novel Recording and Modulation Technologies in the Human CNS (R18 - Clinical Trial Not Allowed)","field_funding_opp_number":"RFA-NS-24-031","field_external_link":"http:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/RFA-NS-24-031.html","field_funding_opp_status":"Open","field_expiration_date":"\u003Ctime datetime=\u00222027-01-29T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2027-01-29\u003C\/time\u003E\n","body":"\u003Cp\u003EAwarded activities will facilitate the translation of novel recording and modulation technologies that can be used to treat and\/or diagnose central nervous system (CNS) diseases and disorders and to better understand the human CNS, from proof of concept up to the stage of readiness for first in human (FIH) studies. Technologies may incorporate any signal modality (e.g., electrical, optical, magnetic, acoustic) or a combination thereof. Diverse team-based applications that integrate appropriate domains of expertise are encouraged.\u003C\/p\u003E","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Investigative Human Neuroscience, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation"},{"title":"BRAIN Initiative: Data Archives for the BRAIN Initiative (R24 Clinical Trial Optional)","field_funding_opp_number":"RFA-MH-25-110","field_external_link":"http:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/RFA-MH-25-110.html","field_funding_opp_status":"Open","field_expiration_date":"\u003Ctime datetime=\u00222026-06-25T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2026-06-25\u003C\/time\u003E\n","body":"\u003Cp\u003EThis Notice of Funding Opportunity (NOFO) solicits applications to develop web-accessible data archives to capture, store, and curate data related to BRAIN Initiative activities. The data archives will work with the research community to incorporate tools that allow users to analyze and visualize the data, but the creation of such tools is not part of this NOFO. The data archives will use appropriate standards to describe the data, but the creation of such standards is not part of this NOFO. A goal of this program is to advance research by creating a community resource data archive with appropriate standards and summary information that is broadly available and accessible to the research community for furthering research.\u003C\/p\u003E","field_grant_mechanism":"Research Project Grants, Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics"},{"title":"BRAIN Initiative: Clinical Studies to Advance Next-Generation Devices for Recording and Modulation in the Human Central Nervous System (UH3 Clinical Trial Optional)","field_funding_opp_number":"RFA-NS-24-017","field_external_link":"http:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/RFA-NS-24-017.html","field_funding_opp_status":"Open","field_expiration_date":"\u003Ctime datetime=\u00222027-01-29T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2027-01-29\u003C\/time\u003E\n","body":"\u003Cp\u003EReissue: RFA-NS-21-024: The purpose of this Funding Opportunity Announcement (FOA) is to encourage investigators to pursue a small clinical trial to obtain critical information necessary to advance recording and\/or stimulating devices to treat central nervous system disorders and better understand the human brain (e.g., Early Feasibility Study). Clinical studies supported may consist of acute or short-term procedures that are deemed Non-Significant Risk (NSR) by an Institutional Review Board (IRB), or Significant Risk (SR) studies that require an Investigational Device Exemption (IDE) from the FDA, such as chronic implants. The clinical trial should provide data to answer key questions about the function or final design of a device. This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval. The clinical trial is expected to provide information that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. Activities supported by this Funding Opportunity include a small clinical trial to answer key questions about the function or final design of a device. As part of the BRAIN Initiative, NIH has initiated a Public-Private Partnership Program (BRAIN PPP) that includes agreements (Memoranda of Understanding, MOU) with a number of device manufacturers willing to make such devices available, including devices and capabilities not yet market approved but appropriate for clinical research. In general it is expected that the devices\u0027 existing safety and utility data will be sufficient to enable new IRB NSR or FDA IDE approval without need for significant additional non-clinical data. For more information on the BRAIN PPP, see \u003Ca href=\u0022http:\/\/braininitiative.nih.gov\/BRAIN_PPP\/index.htm\u0022\u003Ehttp:\/\/braininitiative.nih.gov\/BRAIN_PPP\/index.htm\u003C\/a\u003E\u003C\/p\u003E","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation"},{"title":"BRAIN Initiative: Production and distribution facilities for brain cell type-specific access reagents (U24 Clinical Trial Not Allowed)","field_funding_opp_number":"RFA-MH-25-105","field_external_link":"http:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/RFA-MH-25-105.html","field_funding_opp_status":"Open","field_expiration_date":"\u003Ctime datetime=\u00222026-07-02T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2026-07-02\u003C\/time\u003E\n","body":"\u003Cp\u003EThis BRAIN Initiative Notice of Funding Opportunity (NOFO) is to support scaled reagent production and distribution facilities involving technologies to access brain cell types. Facilities for production and distribution of these reagents by a broad and diverse set of neuroscientists will be encouraged. This NOFO is part of the BRAIN Initiative Armamentarium for Brain Cell Access transformative project. Efforts will be supported to produce and distribute gene transfer, gene regulation, and genome engineering reagents for use in both genetically tractable and less tractable systems, including primates and human tissue, which are relevant for future translational efforts. Reagents to be produced and distributed are those designed and validated under other NOFOs from the Armamentarium transformative project.\u003C\/p\u003E","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Armamentarium","field_research_area":"Training"},{"title":"BRAIN Initiative: Research on the Ethical Implications of Advancements in Neurotechnology and Brain Science (R21 Clinical Trial Optional)","field_funding_opp_number":"RFA-MH-25-171","field_external_link":"http:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/RFA-MH-25-171.html","field_funding_opp_status":"Open","field_expiration_date":"\u003Ctime datetime=\u00222026-10-10T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2026-10-10\u003C\/time\u003E\n","body":"\u003Cp\u003EGuided by the goals established in BRAIN 2025: A Scientific Vision and reinforced by the Advisory Council to the Director Working Group on BRAIN 2.0 Neuroethics Subgroup, this Notice of Funding Opportunity (NOFO) from the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is intended to support efforts addressing core ethical issues associated with research focused on the human brain and resulting from emerging technologies and advancements supported by the BRAIN Initiative. This NOFO encourages research project grant applications from multi-disciplinary teams focused on key ethical issues associated with BRAIN Initiative supported research areas. Efforts supported under this NOFO are intended to be both complementary and integrative with the transformative, breakthrough neuroscience discoveries supported through the BRAIN Initiative.\u003C\/p\u003E","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics"},{"title":"BRAIN Initiative: Research on the Ethical Implications of Advancements in Neurotechnology and Brain Science (R01 Clinical Trial Optional)","field_funding_opp_number":"RFA-MH-25-170","field_external_link":"http:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/RFA-MH-25-170.html","field_funding_opp_status":"Open","field_expiration_date":"\u003Ctime datetime=\u00222026-10-10T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2026-10-10\u003C\/time\u003E\n","body":"\u003Cp\u003EGuided by the goals established in BRAIN 2025: A Scientific Vision and reinforced by the Advisory Council to the Director Working Group on BRAIN 2.0 Neuroethics Subgroup, this Notice of Funding Opportunity (NOFO) from the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is intended to support efforts addressing core ethical issues associated with research focused on the human brain and resulting from emerging technologies and advancements supported by the BRAIN Initiative. This NOFO encourages research project grant applications from multi-disciplinary teams focused on key ethical issues associated with BRAIN Initiative supported research areas. Efforts supported under this NOFO are intended to be both complementary and integrative with the transformative, breakthrough neuroscience discoveries supported through the BRAIN Initiative.\u003C\/p\u003E","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics"},{"title":"BRAIN Initiative: New Concepts and Early-Stage Research for Recording and Modulation in the Nervous System (R21) (Clinical Trial Not Allowed)","field_funding_opp_number":"RFA-EY-23-001","field_external_link":"http:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/RFA-EY-23-001.html","field_funding_opp_status":"Open","field_expiration_date":"\u003Ctime datetime=\u00222026-06-16T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2026-06-16\u003C\/time\u003E\n","body":"\u003Cp\u003EThis FOA seeks applications for unique and innovative recording and\/or modulation technologies that are in the earliest stage of development, including new and untested ideas that are in the initial stages of conceptualization. Some projects may aim to increase recording or modulation capabilities by many orders of magnitude, while others may aim to improve the precision and selectivity of recording or modulation (also referred to as stimulation, perturbation, or manipulation). A wide range of modalities are appropriate including acoustic, chemical, electrical, magnetic, and optical, as well as the use of genetic tools. Invasive or non-invasive approaches are sought that will enable large-scale recording and\/or precise manipulation of neural activity, and that would ultimately be compatible with experiments in humans or behaving animals. Applications are encouraged from any qualified individual, including chemists, physicists, engineers, theoreticians, materials scientists, and others from fields not typically involved with neuroscience research. This FOA requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn.\u003C\/p\u003E","field_grant_mechanism":"Research Project Grants","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation"},{"title":"BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed)","field_funding_opp_number":"RFA-MH-24-280","field_external_link":"http:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/RFA-MH-24-280.html","field_funding_opp_status":"Open","field_expiration_date":"\u003Ctime datetime=\u00222027-02-09T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2027-02-09\u003C\/time\u003E\n","body":"\u003Cp\u003EThe purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function. The new tools and technologies should inform and\/or exploit cell-type and\/or circuit-level specificity. Plans for validating the utility of the tool\/technology will be an essential feature of a successful application. The development of new genetic and non-genetic tools for delivering genes, proteins and chemicals to cells of interest or approaches that are expected to target specific cell types and\/or circuits in the nervous system with greater precision and sensitivity than currently established methods are encouraged. Tools that can be used in a number of species\/model organisms rather than those restricted to a single species are highly desired. Applications that provide approaches that break through existing technical barriers to substantially improve current capabilities are highly encouraged.\u003C\/p\u003E","field_grant_mechanism":"Research Project Grants","field_priority_area":"","field_program":"","field_research_area":""},{"title":"NIH Science Education Partnership Award (SEPA) (R25 - Clinical Trial Not Allowed)","field_funding_opp_number":"PAR-23-137","field_external_link":"https:\/\/grants.nih.gov\/grants\/guide\/pa-files\/PAR-23-137.html","field_funding_opp_status":"Open","field_expiration_date":"\u003Ctime datetime=\u00222025-06-07T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2025-06-07\u003C\/time\u003E\n","body":"\u003Cp\u003EThe NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH.\u0026nbsp; The overarching goal of this\u0026nbsp;R25 program is to support educational activities that encourage individuals from diverse backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences, to pursue further studies or careers in research.\u0026nbsp;\u003C\/p\u003E","field_grant_mechanism":"Research Training \u0026amp; Fellowships","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training"},{"title":"BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Basic Experimental Studies with Humans Required)","field_funding_opp_number":"RFA-DC-24-001","field_external_link":"http:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/RFA-DC-24-001.html","field_funding_opp_status":"Open","field_expiration_date":"\u003Ctime datetime=\u00222025-09-20T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2025-09-20\u003C\/time\u003E\n","body":"\u003Cp\u003EInvasive surgical procedures offer the opportunity for unique intracranial interventions such as the ability to record and stimulate intracranially within precisely localized brain structures in humans. Human studies using invasive technology are often constrained by a limited number of patients and resources available to implement complex experimental protocols and need to be aggregated in a manner that addresses research questions with appropriate statistical power. Therefore, this RFA seeks applications to assemble diverse, integrated, multi-disciplinary teams that cross boundaries of interdisciplinary collaboration to overcome these fundamental barriers and to investigate high-impact questions in human neuroscience. The research should be offered as exploratory research and planning activities to establish feasibility, proof-of-principle and early-stage development that, if successful, would support, enable, and\/or lay the groundwork for a potential, subsequent Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain, as described in the companion FOA (RFA-NS-22-041). Projects should maximize opportunities to conduct innovative in vivo neuroscience research made available by direct access to the brain from invasive surgical procedures. Projects should employ approaches guided by specified theoretical constructs and by quantitative, mechanistic models where appropriate. Awardees will join a consortium working group, coordinated by the NIH, to identify consensus standards of practice, including neuroethical considerations, to collect and provide data for ancillary studies, and to aggregate and standardize data for dissemination among the wider scientific community.\u003C\/p\u003E","field_grant_mechanism":"Research Project Grants","field_priority_area":"Human Neuroscience, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Systems Neuroscience"},{"title":"BRAIN Initiative Fellows: Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (F32)","field_funding_opp_number":"RFA-MH-23-110","field_external_link":"http:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/RFA-MH-23-110.html","field_funding_opp_status":"Open","field_expiration_date":"\u003Ctime datetime=\u00222025-08-12T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2025-08-12\u003C\/time\u003E\n","body":"\u003Cp\u003EThe purpose of the The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative Fellows (F32) program is to enhance the research training of promising postdoctorates, early in their postdoctoral training period, who have the potential to become productive investigators in research areas that will advance the goals of the BRAIN Initiative. Applications are encouraged in any research area that is aligned with the BRAIN Initiative, including neuroethics. Applicants are expected to propose research training in an area that clearly complements their predoctoral research. Formal training in analytical tools appropriate for the proposed research is expected to be an integral component of the research training plan. In order to maximize the training potential of the F32 award, this program encourages applications from individuals who have not yet completed their terminal doctoral degree and who expect to do so within 12 months of the application due date. On the application due date, candidates may not have completed more than 12 months of postdoctoral training.\u003C\/p\u003E","field_grant_mechanism":"Research Training \u0026amp; Fellowships","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training"},{"title":"BRAIN Initiative: New Technologies and Novel Approaches for Recording and Modulation in the Nervous System (R01 Clinical Trial Not Allowed)","field_funding_opp_number":"RFA-NS-24-004","field_external_link":"http:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/RFA-NS-24-004.html","field_funding_opp_status":"Open","field_expiration_date":"\u003Ctime datetime=\u00222026-01-21T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2026-01-21\u003C\/time\u003E\n","body":"\u003Cp\u003EReissue of RFA-NS-18-020: Understanding the dynamic activity of brain circuits is central to the NIH BRAIN Initiative. This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for recording and modulation (including various modalities for stimulation\/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS). This FOA seeks exceptionally creative approaches to address major challenges associated with recording and modulating CNS activity, at or near cellular resolution, at multiple spatial and\/or temporal scales, in any region and throughout the entire depth of the brain. It is expected that the proposed research may be high-risk, but if successful, could profoundly change the course of neuroscience research. Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS. Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, magnetic, acoustic and\/or genetic recording\/manipulation. Applications that seek to integrate multiple approaches are encouraged. If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.\u003C\/p\u003E","field_grant_mechanism":"Research Project Grants","field_priority_area":"Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation"},{"title":"BRAIN Initiative: Optimization of Instrumentation and Device Technologies for Recording and Modulation in the Nervous System (U01 Clinical Trials Not Allowed)","field_funding_opp_number":"RFA-NS-24-005","field_external_link":"http:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/RFA-NS-24-005.html","field_funding_opp_status":"Open","field_expiration_date":"\u003Ctime datetime=\u00222026-01-21T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2026-01-21\u003C\/time\u003E\n","body":"\u003Cp\u003EReissue of RFA-NS-18-019: Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative. The invention, proof-of-concept investigation, and optimization of new technologies through iterative feedback from end users are key components of the BRAIN Initiative. This FOA seeks applications to optimize existing or emerging technologies through iterative testing with end users. The technologies and approaches should have potential to address major challenges associated with recording and modulation (including various modalities for stimulation\/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS). These technologies and approaches should have previously demonstrated their transformative potential through initial proof-of-concept testing and are now ready for accelerated refinement. In conjunction, the manufacturing techniques should be scalable towards sustainable, broad dissemination and user-friendly incorporation into regular neuroscience research.Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS. Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, electrical, magnetic, acoustic or genetic recording\/manipulation. Applications that seek to integrate multiple approaches are encouraged. If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.\u003C\/p\u003E","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation"}]