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nih-gov/www.braininitiative.nih.gov/funding/funding-opportunities/notices?page=4
Scott Williams f361c7df98 Incremental update
2025-03-17 02:05:34 +00:00

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<title>Notices of Funding Opportunities | BRAIN Initiative</title>
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<div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>National Institutes of Health (<a href="/glossary?title=NIH" class="glossary-tooltip" data-toggle="tooltip" title="National Institutes of Health - A Federal agency whose mission is to improve the health of the people of the United States. NIH is a part of the Public Health Service, which is part of the U.S. Department of Health and Human Services. ">NIH</a>) <a href="/glossary?title=BRAIN" class="glossary-tooltip" data-toggle="tooltip" title="The Brain Research through Advancing Innovative Neurotechnologies Initiative aims to accelerate the development and application of innovate technologies to produce a new, dynamic picture of the brain.">BRAIN</a> Initiative notices of funding opportunities (NOFOs), requests for applications (RFAs), program announcements (PAs), and other NIH Guide announcements are listed below. Search <a href="/funding/funding-opportunities/notices">this page</a> to find all notices of special interest (<a href="/glossary?title=NOSI" class="glossary-tooltip" data-toggle="tooltip" title="Notice of Special Interest - Notices posted in the NIH Guide for Grants and Contracts that succinctly highlight a specific topic of interest, for example a specific area of research or program.">NOSI</a>). Search the <a href="/funding/funding-opportunities/closed">Closed Opportunities page</a> to find expired opportunities.&nbsp;&nbsp;</p><p>Learn more about <a href="https://grants.nih.gov/grants/funding/funding_program.htm">NIH’s grant mechanisms</a>.&nbsp;&nbsp;</p><p>Learn about the <a href="https://sharing.nih.gov/data-management-and-sharing-policy/about-data-management-and-sharing-policies/data-management-and-sharing-policy-overview">NIH Data Management and Sharing Policy</a>, which all <a href="/glossary?title=NIH" class="glossary-tooltip" data-toggle="tooltip" title="National Institutes of Health - A Federal agency whose mission is to improve the health of the people of the United States. NIH is a part of the Public Health Service, which is part of the U.S. Department of Health and Human Services. ">NIH</a> applications must follow. &nbsp;</p><p>To see more NIH-funded awards, please visit <a href="https://grants.nih.gov/funding">NIH Grants and Funding</a>.</p><p>For more about <a href="/glossary?title=NIH" class="glossary-tooltip" data-toggle="tooltip" title="National Institutes of Health - A Federal agency whose mission is to improve the health of the people of the United States. NIH is a part of the Public Health Service, which is part of the U.S. Department of Health and Human Services. ">NIH</a> <a href="/glossary?title=BRAIN" class="glossary-tooltip" data-toggle="tooltip" title="The Brain Research through Advancing Innovative Neurotechnologies Initiative aims to accelerate the development and application of innovate technologies to produce a new, dynamic picture of the brain.">BRAIN</a> Initiative research and associated funding opportunities, visit the<a href="/research/research-overview" data-entity-uuid="ddfd32ba-a1f4-475f-a6c0-0b1b109d81d8" data-entity-type="node" data-entity-substitution="canonical"> Research Overview</a>.</p></div>
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<div class="view-field-title col-6">Notice of Intent to Publish a Funding Opportunity Announcement for BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (U01 Clinical Trial Required)</div>
<div class="view-field-release-date col-2"><time datetime="2021-07-20T12:00:00Z" class="datetime">July 20, 2021</time>
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<div class="view-field-expiration-date col-2">January 01 , 2028</div>
<div class="view-field-nofo col-2"><a href="http://grants.nih.gov/grants/guide/notice-files/NOT-NS-21-064.html">NOT-NS-21-064</a></div>
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Invasive surgical procedures provide the unique ability to record and stimulate neurons within precisely localized brain structures in humans. Human studies using invasive technology are often constrained by a limited number of patients and resources available to implement complex experimental protocols and are rarely aggregated in a manner that addresses research questions with appropriate statistical power. Therefore, this RFA seeks applications to assemble diverse, integrated, multi-disciplinary teams that cross boundaries of interdisciplinary collaboration to overcome these fundamental barriers and to investigate high-impact questions in human neuroscience. Projects should maximize opportunities to conduct innovative in vivo neuroscience research made available by direct access to brain recording and stimulating from invasive surgical procedures. Projects should employ approaches guided by specified theoretical constructs and quantitative, mechanistic models where appropriate.
Awardees will join a consortium work group, coordinated by the NIH, to identify consensus standards of practice, including neuroethical considerations, to collect and provide data for ancillary studies, and to aggregate and standardize data for dissemination among the wider scientific community.</div>
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<div class="view-field-title col-6">Notice of Change in Application Type for BRAIN Initiative: Team-Research BRAIN Circuit Programs TeamBCP</div>
<div class="view-field-release-date col-2"><time datetime="2021-05-26T12:00:00Z" class="datetime">May 26, 2021</time>
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<div class="view-field-expiration-date col-2">January 01 , 2028</div>
<div class="view-field-nofo col-2"><a href="http://grants.nih.gov/grants/guide/notice-files/NOT-NS-21-065.html">NOT-NS-21-065</a></div>
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Change of application types allowed for BRAIN Initiative: Team-Research BRAIN Circuit Programs TeamBCP, RFA-NS-19-002 (U19 Clinical Trial Required) and RFA-NS-19-003 (U19 Clinical Trial Not Allowed).
Effective immediately, this Notice allows Type 2, renewal applications for the remaining receipt date on October 29, 2021 by 5:PM local time of the applicant organization. Acceptance of new Type 1 applications remains unchanged.</div>
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<div class="view-field-title col-6">Notice of Correction to Eligibility Information of RFA-MH-21-180, &quot;BRAIN Initiative: Reagent Resources for Brain Cell Type-Specific Access and Manipulation to Broaden Distribution of Enabling Technologies for Neuroscience (U24 Clinical Trial Not Allowed)&quot;</div>
<div class="view-field-release-date col-2"><time datetime="2021-05-07T12:00:00Z" class="datetime">May 07, 2021</time>
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<div class="view-field-expiration-date col-2">January 01 , 2028</div>
<div class="view-field-nofo col-2"><a href="http://grants.nih.gov/grants/guide/notice-files/NOT-MH-21-280.html">NOT-MH-21-280</a></div>
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This notice corrects the eligibility information for RFA-MH-21-180, "BRAIN Initiative: Reagent Resources for Brain Cell Type-Specific Access and Manipulation to Broaden Distribution of Enabling Technologies for Neuroscience (U24 Clinical Trial Not Allowed)" to clarify that NIH intramural candidates are eligible to apply.</div>
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<div class="view-field-title col-6">Notice of Intent to Publish a Funding Opportunity Announcement for BRAIN Initiative Cell Atlas Network (BICAN): Comprehensive Center on Human and Non-human Primate Brain Cell Atlases (UM1 Clinical Trial Not Allowed)</div>
<div class="view-field-release-date col-2"><time datetime="2021-04-27T12:00:00Z" class="datetime">April 27, 2021</time>
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<div class="view-field-expiration-date col-2">January 01 , 2028</div>
<div class="view-field-nofo col-2"><a href="http://grants.nih.gov/grants/guide/notice-files/NOT-MH-21-260.html">NOT-MH-21-260</a></div>
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NOITP for RFA-MH-21-235 This Funding Opportunity Announcement (FOA) intends to support a group of large-scale Comprehensive Centers that will adopt scalable technology platforms and streamlined sampling strategies and assay cascade to create comprehensive and highly granular brain cell atlases of human and non-human primates with an emphasis on human. The Centers are expected to characterize all brain cell types (neurons, glia, and other non-neuronal cells) at high-resolution. The overarching goal of the BICAN is to build reference brain cell atlases that will be widely used throughout the research community, providing a molecular and anatomical foundational framework for the study of brain function and disorders.</div>
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<div class="view-field-title col-6">Notice of Intent to Publish a Funding Opportunity Announcement for BRAIN Initiative Cell Atlas Network (BICAN): Specialized Collaboratory on Human, Non-human Primate, and Mouse Brain Cell Atlases (U01 Clinical Trial Not Allowed)</div>
<div class="view-field-release-date col-2"><time datetime="2021-04-27T12:00:00Z" class="datetime">April 27, 2021</time>
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<div class="view-field-expiration-date col-2">January 01 , 2028</div>
<div class="view-field-nofo col-2"><a href="http://grants.nih.gov/grants/guide/notice-files/NOT-MH-21-261.html">NOT-MH-21-261</a></div>
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NOITP for RFA-MH-21-236 This Funding Opportunity Announcement (FOA) intends to support a group of Specialized Collaboratories that will adopt scalable technology platforms and streamlined sampling strategies and assay cascade to create comprehensive and highly granular brain cell atlases in human, non-human primates, and mouse, in coordination and collaboration with other BICAN projects. In particular, the Specialized Collaboratories are expected to complement the Comprehensive Centers in BICAN with distinct capabilities, competencies, and research aims. The overarching goal of the BICAN is to build reference brain cell atlases that will be widely used throughout the research community, providing a molecular and anatomical foundational framework for the study of brain function and disorders.</div>
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<div class="view-field-title col-6">Notice of Intent to Publish a Funding Opportunity Announcement for BRAIN Initiative Cell Atlas Network (BICAN): Coordinating Unit for Biostatistics, Informatics, and Engagement (CUBIE) (U24 Clinical Trial Not Allowed)</div>
<div class="view-field-release-date col-2"><time datetime="2021-04-27T12:00:00Z" class="datetime">April 27, 2021</time>
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<div class="view-field-expiration-date col-2">January 01 , 2028</div>
<div class="view-field-nofo col-2"><a href="http://grants.nih.gov/grants/guide/notice-files/NOT-MH-21-262.html">NOT-MH-21-262</a></div>
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NOITP for RFA-MH-21-237 This Funding Opportunity Announcement (FOA) intends to support a Coordinating Unit for Biostatistics, Informatics, and Engagement (CUBIE) that will be composed of four components to establish respectively (1) a common sequencing data processing pipeline, (2) a common imaging data processing pipeline, (3) a comprehensive brain cell knowledge base, and (4) an engaging and outreach component to coordinate the research within and beyond BICAN. The overall goals of CUBIE are to (i) enable the exploration of large-scale brain cell atlas data and knowledge, and inspire research in brain function and disorders; and (ii) ensure research rigor and data reproducibility by making the data to be findable, accessible, interoperable, and reusable, and the process transparent. An application is expected to propose only one of the above four respective components.</div>
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<div class="view-field-title col-6">Notice of Change: Receipt date added for RFA-EB-20-002, &quot;BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed)</div>
<div class="view-field-release-date col-2"><time datetime="2021-04-14T12:00:00Z" class="datetime">April 14, 2021</time>
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<div class="view-field-expiration-date col-2">January 01 , 2028</div>
<div class="view-field-nofo col-2"><a href="http://grants.nih.gov/grants/guide/notice-files/NOT-EB-21-006.html">NOT-EB-21-006</a></div>
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The purpose of this Notice is to inform interested applicants that the expiration date in PAR-18-205 " NIBIB Biomedical Technology Resource Centers (P41 Clinical Trials Optional)" will be extended by one receipt cycle (See changes in bold italics below).
Part 1. Overview
Key Dates
Currently Reads: Expiration Date January 8, 2021
Modified to Read: Expiration Date May 8, 2021
All other aspects of this FOA remain unchanged.</div>
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<div class="view-field-title col-6">Notice of Intent to Publish the Reissuance of RFA-NS-18-020, BRAIN Initiative: Novel Technologies and Approaches for Recording and Modulation in the Nervous System (R01 Clinical Trial Not Allowed)</div>
<div class="view-field-release-date col-2"><time datetime="2021-04-02T12:00:00Z" class="datetime">April 02, 2021</time>
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<div class="view-field-expiration-date col-2">January 01 , 2028</div>
<div class="view-field-nofo col-2"><a href="http://grants.nih.gov/grants/guide/notice-files/NOT-NS-21-051.html">NOT-NS-21-051</a></div>
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Reissue of RFA-NS-18-020: Understanding the dynamic activity of brain circuits is central to the NIH BRAIN Initiative. This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS). This FOA seeks exceptionally creative approaches to address major challenges associated with recording and modulating CNS activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain. It is expected that the proposed research may be high-risk, but if successful, could profoundly change the course of neuroscience research.
Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS. Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, magnetic, acoustic and/or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.</div>
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<div class="view-field-title col-6">Notice of Intent to Publish the Reissuance of RFA-NS-18-019, BRAIN Initiative: Optimization of Transformative Technologies for Recording and Modulation in the Nervous System (U01 Clinical Trials Not Allowed)</div>
<div class="view-field-release-date col-2"><time datetime="2021-04-02T12:00:00Z" class="datetime">April 02, 2021</time>
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<div class="view-field-expiration-date col-2">January 01 , 2028</div>
<div class="view-field-nofo col-2"><a href="http://grants.nih.gov/grants/guide/notice-files/NOT-NS-21-052.html">NOT-NS-21-052</a></div>
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Reissue of RFA-NS-18-019: Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative. The invention, proof-of-concept investigation, and optimization of new technologies through iterative feedback from end users are key components of the BRAIN Initiative. This FOA seeks applications to optimize existing or emerging technologies through iterative testing with end users. The technologies and approaches should have potential to address major challenges associated with recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS). These technologies and approaches should have previously demonstrated their transformative potential through initial proof-of-concept testing and are now ready for accelerated refinement. In conjunction, the manufacturing techniques should be scalable towards sustainable, broad dissemination and user-friendly incorporation into regular neuroscience research.
Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS. Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, electrical, magnetic, acoustic or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.</div>
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<div class="view-field-title col-6">Notice of Change to Key Dates for RFA-NS-20-006 &quot;BRAIN Initiative: Biology and Biophysics of Neural Stimulation and Recording Technologies (R01 Clinical Trials Optional)&quot;</div>
<div class="view-field-release-date col-2"><time datetime="2021-03-23T12:00:00Z" class="datetime">March 23, 2021</time>
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<div class="view-field-expiration-date col-2">January 01 , 2028</div>
<div class="view-field-nofo col-2"><a href="http://grants.nih.gov/grants/guide/notice-files/NOT-NS-21-046.html">NOT-NS-21-046</a></div>
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This notice informs applicants of a change to the Key Dates for RFA-NS-20-006 "BRAIN Initiative: Biology and Biophysics of Neural Stimulation and Recording Technologies (R01 Clinical Trials Optional)". Two of the receipt dates, the October 1, 2021 and June 1, 2022 receipt dates have been cancelled from this Funding Opportunity Announcement (FOA).</div>
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