nih-gov/www.braininitiative.nih.gov/funding/funding-opportunities/closed.csv?page&_format=csv

Title,"Funding Opportunity Number","Grants URL","Funding Status","Expiration Date",Purpose,"Grant Mechanism","Priority Area",Program,"Research Area"
"BRAIN Initiative: Brain Behavior Quantification and Synchronization (R61/R33 Clinical Trial Optional)",RFA-MH-26-100,http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-26-100.html,Closed,2025-01-23,"The goal of this effort is to support the development and validation of next generation platforms and analytic approaches to precisely quantify behaviors in humans and link them with simultaneously recorded brain activity. Tools used for analyzing behavior should be multi-modal and should be able to be linked to brain activity and thus have the accuracy, specificity, temporal resolution, and flexibility commensurate with tools used to measure and modulate the brain circuits that give rise to those behaviors. This phased award will support novel tool development (i.e., hardware/software) in the R61 phase and synchronization of novel tools for measuring behavior and human brain activity in the R33 phase.","Research Projects","Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools","BBQS, Investigative Human Neuroscience","Human Neuroscience, Neural Recording & Modulation"
"BRAIN Initiative: Scaled reagent resources for brain cell type-specific access across vertebrate species (U01 Clinical Trial Not Allowed)",RFA-MH-25-100,http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-25-100.html,Closed,2025-01-18,"This BRAIN Initiative Notice of Funding Opportunity (NOFO) is to scale up efforts for viral, non-viral, transgenic, and gene regulatory element screening technologies and create reagent resources to access brain cell types. This NOFO is part of the BRAIN Initiative Armamentarium for Brain Cell Access transformative project. Reagent development efforts will apply gene transfer, gene regulation, genome engineering, activity sensor/effector, and atlasing technologies for use in both genetically tractable and less tractable systems, including primates and human tissue, which are relevant for future translational efforts. Reagent validation studies will provide feedback to improve scaled resources, informed by deeper understanding of neural gene transfer and regulation mechanisms. Precise targeting could ultimately aid in human disorders, for example, by providing access for gene editors to specific cell types to repair mutations.","Cooperative Agreements","Cell Type, Monitor Neural Activity",Armamentarium,"Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative: Brain-Behavior Quantification and Synchronization  Transformative and Integrative Models of Behavior at the Organismal Level (R34 Clinical Trial Optional)",RFA-DA-24-042,http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-24-042.html,Closed,2024-02-16,"This notice of funding opportunity (NOFO) seeks applications proposing a set of planning activities that will lay the groundwork for a scientific project aimed at integrating complementary theories and methods to 1) develop, validate, and apply cutting-edge tools and methods for minimally invasive, multi-dimensional, high-resolution measurement of behavior at the level of the organism, with synchronous capture of changes in the organisms social or physical environment; and 2) develop data science and computational methods that allow for integration of multidimensional behavioral and environmental datarepresenting multiple timescales, and that will establish of a conceptual and/or computational model of behavior as a complex dynamic system. Prospective projects are expected to be designed with the potential to integrate synchronously recorded neural data and/or inform existing models of neurobehavioral function, such as those developed with the support of the NIH BRAIN Initiative. The purpose of this R34 planning grant opportunity is to support planning and development of the research framework, design, and approach, including activities that will establish feasibility, validity, and/or other technically qualifying results that, if successful, would support a competitive application for a U01, or equivalent, NIH research award. This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn. Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.","Research Projects","Integrated Approaches, Monitor Neural Activity, Theory & Data Analysis Tools","BBQS, Understanding Circuits","Systems Neuroscience"
"BRAIN Initiative: Marmoset Colonies for Neuroscience Research (U24 Clinical Trials Not Allowed)",RFA-MH-25-115,http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-25-115.html,Closed,2024-03-02,"The common marmoset (Callithrix jacchus) has emerged as a promising nonhuman primate model system to understand the primate brain. This has come about both from the realization that the behavior of the common marmoset is similar in some ways to human behavior and from recent demonstration of germline transmission of exogenous genetic information. This Notice of Funding Opportunity (NOFO) solicits applications to expand existing colonies of the common marmoset for neuroscience research in the United States, and to support the care, breeding and distribution of genetically modified marmosets, and cryopreserved embryos and gametes created by NIH-funded research programs such as the NIH BRAIN Initiative Tools for Germline Gene Editing in Marmosets research consortium. Recipients s under this NOFO are expected to expand their current marmoset colonies to provide healthy, well-characterized animals that will be made available to the neuroscience research community, and to include a plan to accept genetically modified marmosets, and cryopreserved embryos and gametes for distribution to the research community. Recipients are also expected to participate in and provide health and genetic information to an NIH-Funded Marmoset Coordination Center to help the community understand the pedigree of individuals in the captive marmoset population and improve the genetic diversity of that population across multiple colonies.","Cooperative Agreements","Cell Type, Circuit Diagrams",,"Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative:  Marmoset Coordination Center (U24 Clinical Trials Not Allowed)",RFA-MH-25-116,http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-25-116.html,Closed,2024-03-02,"This Notice of Funding Opportunity (NOFO) solicits applications to create a Marmoset Coordination Center. The awardee will be responsible for two separate but related activities. The first activity will be to become the repository for genomic, pedigree, and event records (date of birth, medical, reproductive history) for captive marmosets. The awardee is expected to use that information to help make breeding recommendations to maximize the health and genetic diversity of the marmosets in primate colonies. Applicants are encouraged to adopt the model used by the Association of Zoos and Aquariums.","Cooperative Agreements","Cell Type, Circuit Diagrams",,"Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative Connectivity across Scales Data Coordinating Center (BRAIN CONNECTS DCC) (U24 Clinical Trial Not Allowed)",RFA-NS-24-028,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-24-028.html,Closed,2024-08-20,"This Notice of Funding Opportunity (NOFO) solicits applications for one or more Data Coordinating Centers (DCCs) to support BRAIN CONNECTS, a networked consortium of Comprehensive Centers and Specialized Projects funded under RFA-NS-22-047, RFA-NS-22-048, and RFA-NS-22-049. The goals of these awards are to develop the research capacity and technical capabilities for comprehensive brain-wide connectivity mapping in mouse, human, and non-human primate (NHP). BRAIN CONNECTS projects will collect and process unprecedented volumes of anatomical data by scaling up cutting-edge acquisition modalities and analysis methods, to demonstrate the feasibility of collecting, reconstructing, analyzing, integrating, disseminating, and interpreting connectivity maps from entire brains. The resulting feasibility data from these awards are expected to inform NIH decisions on program continuation in a potential subsequent five-year funding period for production of brain-wide wiring diagrams. NIH expects to fund one or more BRAIN CONNECTS DCCs, which will collaborate with CONNECTS data generating projects to (1) coordinate activities of the BRAIN CONNECTS Network, (2) develop and harmonize common data processing pipelines, (3) integrate and disseminate data analytic tools and capabilities, (4) establish a unified knowledge base for connectivity data of diverse modalities, and (5) organize and implement outreach and engagement to the wider research community and the general public. Awards will be integrated into the BRAIN CONNECTS Network as a coordinated effort aimed at developing the ability to generate wiring diagrams spanning entire brains across multiple scales and species.","Cooperative Agreements","Cell Type, Circuit Diagrams, Theory & Data Analysis Tools","BRAIN CONNECTS, Understanding Circuits","Data Science & Informatics, Human Neuroscience, Neuroimaging Technologies Across Scales"
"BRAIN Initiative: Research on the Ethical Implications of Advancements in Neurotechnology and Brain Science (R01 Clinical Trial Optional)",RFA-MH-24-190,http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-24-190.html,Closed,2023-10-12,"Reissue of RFA-MH-21-205 to comply with DMS Policy. This Notice of Funding Opportunity (NOFO), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, is one of several NOFOs aimed at supporting transformative discoveries that will lead to breakthroughs in understanding human brain function. Guided by the long-term scientific plan, BRAIN 2025: A Scientific Vision, this NOFO specifically seeks to support efforts addressing core ethical issues associated with research focused on the human brain and resulting from emerging technologies and advancements supported by the BRAIN Initiative. The hope is that efforts supported under this NOFO might be both complementary and integrative with the transformative, breakthrough neuroscience discoveries supported through the BRAIN Initiative.","Research Project Grants","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools",Neuroethics,Neuroethics
"Notice of Special Interest (NOSI): Availability of Administrative Supplements for BRAIN Initiative Recipients to Support Resource Dissemination",NOT-EB-23-010,http://grants.nih.gov/grants/guide/notice-files/NOT-EB-23-010.html,Closed,2024-08-31,"The goal of this NOSI is to accelerate the scientific impact of the BRAIN Initiative through rapid dissemination of promising technologies and resources to the neuroscience research community. This NOSI will support small dissemination efforts for which a clear value to the identified user group is demonstrated in the application. The proposed work must be within the scope of the original project of the eligible parent award but beyond the original dissemination plans included in the parent application.","Career Development Awards, Conference Grants, Cooperative Agreements, Institutional Training Awards, Research Project Grants, Program Project/Center Grants, Research Training & Fellowships, Resource Grants, Small Business Grants",,,
"Notice of Special Interest (NOSI): BRAIN Initiative: Mentored Clinician Scientist Research Career Development program to Develop Expertise in Intracranial Human Neuroscience Research (K08)",NOT-AA-23-015,http://grants.nih.gov/grants/guide/notice-files/NOT-AA-23-015.html,Closed,2024-02-13,"The purpose of this Notice of Special Interest (NOSI) is to promote the availability of Mentored Clinician Scientist Research Career Development Awards (K08) applications in research areas covered by the NIH BRAIN Initiative. This program will provide support and protected time (3-5 years) for clinicians to develop new and/or expand their expertise in intracranial human neuroscience research. The goal of the program is to build an interdisciplinary and diverse research workforce dedicated to capitalizing on intracranial neural recording and/or stimulating technologies to answer high-impact questions in human neuroscience.","Career Development Awards",,,
"BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed)",RFA-MH-23-290,http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-23-290.html,Closed,2023-06-08,"This is a reissue of RFA-MH-21-175 to comply with DMSP policy. The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function. The new tools and technologies should inform and/or exploit cell-type and/or circuit-level specificity. Plans for validating the utility of the tool/technology will be an essential feature of a successful application. The development of new genetic and non-genetic tools for delivering genes, proteins and chemicals to cells of interest or approaches that are expected to target specific cell types and/or circuits in the nervous system with greater precision and sensitivity than currently established methods are encouraged. Tools that can be used in a number of species/model organisms rather than those restricted to a single species are highly desired. Applications that provide approaches that break through existing technical barriers to substantially improve current capabilities are highly encouraged.","Research Project Grants","Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity",,"Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative: Development of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in Human and Non-Human Primate Brain (UG3/UH3 Clinical Trial Optional)",RFA-MH-23-295,http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-23-295.html,Closed,2024-06-08,"Reissue of RFA-MH-22-115 to comply with DMSP policy. The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis and manipulation of complex circuits and provide insights into cellular interactions that underlie brain function. Critical advances in the treatment of brain disorders in human populations are hindered by our lack of ability to monitor and manipulate circuitry in safe, minimally-invasive ways. Clinical intervention with novel cell and circuit specific tools will require extensive focused research designed to remove barriers to delivery of gene therapies. In addition to identification and removal of barriers, the need to specifically target dysfunctional circuitry poses additional challenges. Neuroscience has experienced an impressive influx of exciting new research tools in the past decade, especially since the launch of the BRAIN Initiative. However, the majority of these cutting edge tools have been developed for use in model organisms, primarily rodents, fish and flies. These cutting edge tools, such as viral delivery of genetic constructs, are increasingly adaptable to large brains and more importantly are emerging as potential human therapeutic strategies for brain disorders. A pressing need to develop tools for use in large brains, more directly relevant to the human brain is the focus of this initiative. The new tools and technologies should inform and/or exploit cell-type and/or circuit-level specificity. Plans for validating the utility of the tool/technology will be an essential feature of a successful application.","Cooperative Agreements","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools","Understanding Circuits","Human Neuroscience, Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative: Targeted BRAIN Circuits Planning Projects  TargetedBCPP (R34 Clinical Trials Not Allowed)",RFA-NS-23-023,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-23-023.html,Closed,2024-10-03,"Reissue of RFA-NS-22-027 to comply with DMSP - No new dates are being added. (Reissue of RFA-NS-18-014 and RFA-NS-21-014) This R34 NOFO solicits applications that offer a limited scope of aims and an approach that will establish feasibility, validity, or other technically qualifying results that, if successful, would support, enable, and/or lay the groundwork for a potential, subsequent Targeted Brain Circuits Projects - TargetedBCP R01, as described in the companion NOFO (RFA-NS-22-026). Applications should be exploratory research projects that use innovative, methodologically-integrated approaches to understand how circuit activity gives rise to mental experience and behavior.","Research Project Grants","Circuit Diagrams, Integrated Approaches, Monitor Neural Activity","Understanding Circuits","Systems Neuroscience"
"BRAIN Initiative: Targeted BRAIN Circuits Projects- TargetedBCP (R01 Clinical Trial Not Allowed)",RFA-NS-23-024,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-23-024.html,Closed,2024-10-03,"Reissue of RFA-NS-22-026 to comply with DMSP - No new dates are being added.(Reissue of RFA-NS-18-030) This NOFO solicits applications for research projects that use innovative, methodologically-integrated approaches to understand how circuit activity gives rise to mental experience and behavior. The goal is to support projects that can realize a meaningful outcome within 5 years. Applications should address circuit function in the context of specific neural systems such as sensation, perception, attention, reasoning, intention, decision-making, emotion, navigation, communication or homeostasis. Projects should link theory and data analysis to experimental design and should produce predictive models as deliverables. Projects should aim to improve the understanding of circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating dynamic patterns of neural activity. Projects can use non-human and human species, and applications should explain how the selected species offers ideal conditions for revealing general principles about the circuit basis of a specific behavior.","Research Project Grants","Circuit Diagrams, Integrated Approaches","Understanding Circuits","Systems Neuroscience"
"BRAIN Initiative:  Exploratory Team-Research BRAIN Circuit Programs - eTeamBCP (U01 Clinical Trials Optional)",RFA-NS-23-025,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-23-025.html,Closed,2024-06-15,"Reissue of RFA-NS-22-028 to comply with DMSP - No new dates are being added. Reissue of:RFA-NS-18-029 and RFA-NS-20-029. This funding opportunity announcement (FOA) is designed to support teams of investigators that seek to cross boundaries of interdisciplinary collaboration to elucidate the contributions of dynamic circuit activity to a specific behavioral or neural system. Applications are encouraged to propose adventurous and challenging goals that can only be tackled by a synergistic team-based approach and have the potential to be transformative and/or to enable significant advances. These studies at the exploratory stage are intended for the development of experimental capabilities and/or theoretical frameworks in preparation for a future competition for larger-scale or extended efforts, including the BRAIN TargetedBCP R01 or the multi-component, Team-Research BRAIN Circuit Programs (U19). The overall goal of this FOA is to enable a large-scale analysis of neural systems and circuits within the context and during the simultaneous measurement of an ethologically relevant behavior. Toward this end, teams are expected to assemble and leverage multi-disciplinary expertise, and to integrate experimental with computational and theoretical approaches. Teams are expected to bridge fields by incorporating rich information on cell-types, on circuit functionality and connectivity, in conjunction with sophisticated analyses of an ethologically relevant behavior of an organism or a well-defined neural system. Teams are also expected to aim for a mechanistic understanding of the circuits of the central nervous system (CNS) by applying cutting-edge methods such as those for large-scale recording, manipulation, and analysis of neural circuits across multiple regions of the CNS.","Cooperative Agreements","Circuit Diagrams, Integrated Approaches","Understanding Circuits","Systems Neuroscience"
"BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed)",RFA-NS-23-026,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-23-026.html,Closed,2024-10-12,"Reissue of RFA-NS-22-011 to comply with DMSP. No additional receipt dates added. This funding opportunity announcement (FOA) supports efforts to disseminate resources and to integrate them into neuroscience research practice. Projects should be highly relevant to specific goals of the BRAIN Initiative, goals that are described in the planning document ""BRAIN 2025: A Scientific Vision."" They should engage in one or more of the following activities: distribution of tools and reagents; user training on the usage of new technologies or techniques; providing access to existing technology platforms and specialized facilities; minor improvements to increase the scale/efficiency of resource production and delivery; minor adaptations to meet the needs of a user community. Applications strictly focused on technology or software development, rather than dissemination of an existing resource, are not responsive to this FOA. Refinements to microscopes or tools necessary to customize them to the experimental needs of the end users is allowed. Projects should address compelling needs of neuroscience researchers working toward the goals of the BRAIN 2025 report that are otherwise unavailable or impractical in their current form.","Cooperative Agreements","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools","Dissemination, Informatics",Dissemination
"BRAIN Initiative: Integration and Analysis of BRAIN Initiative Data (R01 Clinical Trial Not Allowed)",RFA-MH-23-270,http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-23-270.html,Closed,2024-06-08,"Reissue of RFA-MH-22-220 to comply with DMSP. This FOA supports the development of software to visualize and analyze the data as part of programs of building the informatics infrastructure for the BRAIN Initiative. Other informatics programs include developing data standards that are needed to describe the new experiments that are being created by or used in the BRAIN Initiative ( RFA-MH-19-146 ), and creating the data infrastructures that will house the data from multiple experimental groups ( RFA-MH-19-145 ). Each of the programs is aimed at building an infrastructure that is used by a particular sub-domain of experimentalists rather than building a single all-encompassing informatics infrastructure now. Building the infrastructure one experimental area at a time will ensure that the infrastructure is immediately useful to components of the research community. As our understanding of the brain improves, it may be possible to create linkages between these various sub-domain specific informatics programs. Investigators of the informatics programs should keep that goal in mind and build for the future even though the current efforts are more limited in scope.","Research Project Grants","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools",Informatics,"Data Science & Informatics"
"BRAIN Initiative: Brain Behavior Quantification and Synchronization  Data Coordination and Artificial Intelligence Center (U24 Clinical Trial Optional)",RFA-MH-23-130,http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-23-130.html,Closed,2023-07-15,"This funding opportunity announcement (FOA) invites applications for creating the Data Coordination and Artificial Intelligence Center (DCAIC) for the Brain Behavior Quantification and Synchronization (BBQS) Consortium of the BRAIN Initiative. The FOA will support a single award to a multi-disciplinary team with a single or multiple PIs working on the five interrelated areas:1) Data Management; 2) Data Standards; 3) ML/AI Resources; 4) Data Ecosystem; and 5) Dissemination, Training and Coordination.","Cooperative Agreements","Integrated Approaches, Monitor Neural Activity, Theory & Data Analysis Tools","BBQS, Informatics","Data Science & Informatics"
"BRAIN Initiative: Transformative Brain Non-invasive Imaging Technology Development (UG3/UH3 Clinical Trial Not Allowed)",RFA-EB-22-003,http://grants.nih.gov/grants/guide/rfa-files/RFA-EB-22-003.html,Closed,2023-10-14,"This Funding Opportunity Announcement (FOA) solicits applications for team-centric development and validation of innovative non-invasive imaging technologies that could have a transformative impact on the study of brain function/connectivity. Applications are expected to turn a novel concept into a functional prototype using this phased grant mechanism. The feasibility should be established by the end of its first phase and serve as a foundation for the transition to its second phase. Fully developing the technology into a functional prototype and validating it by in-vivo animal or human function/connectivity imaging are anticipated in the second phase. The research plan should provide a realistic timeline and tangible milestones to support the proposed development effort. Awards will be integrated into the BRAIN Non-Invasive Imaging Consortium, as a coordinated network on brain function/connectivity imaging.","Cooperative Agreements","Circuit Diagrams, Human Neuroscience, Monitor Neural Activity","Investigative Human Neuroscience","Neuroimaging Technologies Across Scales"
"BRAIN Initiative: Brain Behavior Quantification and Synchronization (R61/R33 Clinical Trial Optional)",RFA-MH-23-335,http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-23-335.html,Closed,2024-02-16,"The goal of this effort is to support the development and validation of next generation platforms and analytic approaches to precisely quantify behaviors in humans and link them with simultaneously recorded brain activity. Tools used for analyzing behavior should be multi-modal and should be able to be linked to brain activity and thus have the accuracy, specificity, temporal resolution, and flexibility commensurate with tools used to measure and modulate the brain circuits that give rise to those behaviors. This phased award will support novel tool development (i.e., hardware/software) in the R61 phase and synchronization of novel tools for measuring behavior and human brain activity in the R33 phase.","Research Project Grants","Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools","BBQS, Investigative Human Neuroscience","Human Neuroscience, Neural Recording & Modulation"
"BRAIN Initiative: Brain-Behavior Quantification and Synchronization  Transformative and Integrative Models of Behavior at the Organismal Level (R34 Clinical Trial Not Allowed)",RFA-DA-23-030,https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-23-030.html,Closed,2023-02-15,"This R34 Funding Opportunity Announcement (FOA) seeks applications with limited scope proposing a set of planning activities that will lay the groundwork for a scientific project aimed at integrating complementary theories and methods to 1) develop, validate and apply cutting-edge tools and methods for minimally invasive, multi-dimensional, high-resolution measurement of behavior at the level of the organism, with synchronous capture of changes in the organisms social or physical environment; and/or 2) develop computational methods that allow for integration of multidimensional behavioral and environmental datarepresenting multiple timescales into a conceptual and/or computational model of behavior as a complex dynamic system, designed with the capacity to integrate synchronously recorded neural data and/or inform existing models of neurobehavioral function, such as those developed with the support of the NIH BRAIN Initiative. The purpose of this R34 funding opportunity is to support planning and development of the research framework, design, and approach, including activities that will establish feasibility, validity, and/or other technically qualifying results that, if successful, would support a competitive application for a U01, R01 or equivalent NIH research award.","Research Project Grants","Integrated Approaches, Monitor Neural Activity, Theory & Data Analysis Tools","BBQS, Understanding Circuits","Systems Neuroscience"
"BRAIN Initiative Cell Atlas Network (BICAN): Specialized Collaboratory on Human, Non-human Primate, and Mouse Brain Cell Atlases (R01 Clinical Trial Not Allowed)",RFA-MH-22-292,http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-22-292.html,Closed,2024-02-02,"This Funding Opportunity Announcement (FOA) intends to support a group of Specialized Collaboratories that will adopt scalable technology platforms and streamlined sampling strategies and assay cascade to create comprehensive and highly granular brain cell atlases in human, non-human primates, and mouse, in coordination and collaboration with other BICAN projects. In particular, the Specialized Collaboratories are expected to complement the Comprehensive Centers in BICAN with distinct capabilities, competencies, and research aims. The overarching goal of the BICAN is to build reference brain cell atlases that will be widely used throughout the research community, providing a molecular and anatomical foundational framework for the study of brain function and disorders.","Research Project Grants","Cell Type, Circuit Diagrams","BICAN, Understanding Circuits","Human Neuroscience, Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative Cell Atlas Network (BICAN): Coordinating Unit for Biostatistics, Informatics, and Engagement (CUBIE) (U24 Clinical Trial Not Allowed)",RFA-MH-22-291,https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-22-291.html,Closed,2023-02-02,"This Funding Opportunity Announcement (FOA) intends to support a Coordinating Unit for Biostatistics, Informatics, and Engagement (CUBIE) that will be composed of four components to establish respectively (1) a common sequencing data processing pipeline, (2) a common imaging data processing pipeline, (3) a comprehensive brain cell knowledge base, and (4) an engaging and outreach component to coordinate the research within and beyond BICAN. The overall goals of CUBIE are to (i) enable the exploration of large-scale brain cell atlas data and knowledge, and inspire research in brain function and disorders; and (ii) ensure research rigor and data reproducibility by making the data to be findable, accessible, interoperable, and reusable, and the process transparent. An application is expected to propose only one of the above four respective components.","Cooperative Agreements","Cell Type, Circuit Diagrams",BICAN,"Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative Cell Atlas Network (BICAN): Comprehensive Center on Human and Non-human Primate Brain Cell Atlases (UM1 Clinical Trial Not Allowed)",RFA-MH-22-290,https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-22-290.html,Closed,2023-02-02,"This Funding Opportunity Announcement (FOA) intends to support a group of large-scale Comprehensive Centers that will adopt scalable technology platforms and streamlined sampling strategies and assay cascade to create comprehensive and highly granular brain cell atlases of human and non-human primates with an emphasis on human. The Centers are expected to characterize all brain cell types (neurons, glia, and other non-neuronal cells) at high-resolution. The overarching goal of the BICAN is to build reference brain cell atlases that will be widely used throughout the research community, providing a molecular and anatomical foundational framework for the study of brain function and disorders.","Cooperative Agreements","Cell Type, Circuit Diagrams",BICAN,"Human Neuroscience, Tools/Tech for Brain Cells/Circuits"
"Notice of Special Interest (NOSI): BRAIN Initiative: Notice of Support for Research on Interoception Circuits",NOT-AT-23-003,http://grants.nih.gov/grants/guide/notice-files/NOT-AT-23-003.html,Closed,2024-10-03,"The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is aimed at revolutionizing neuroscience through development and application of innovative technologies to map neural circuits, monitor and modulate their activity, and understand how they contribute to thoughts, sensations, emotions, and behaviors.  NIH has issued a variety of Funding Opportunity Announcements (FOAs) that will support projects that apply technologies to understand neural circuit function in the context of specific circuits, resulting in a diverse portfolio of research into the fundamental biology of nervous system function.",,,,
"BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed)",RFA-DA-23-039,http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-23-039.html,Closed,2024-09-13,"This FOA solicits the development of theories, computational models, and analytical tools to derive understanding of brain function from complex neuroscience data. Proposed projects could develop tools to integrate existing theories or formulate new theories; conceptual frameworks to organize or fuse data to infer general principles of brain function; multiscale/multiphysics models to generate new testable hypotheses to design/drive future experiments; new analytical methods to either support or refute a stated hypothesis about brain function. It is expected that the tools developed under this FOA will be made widely available to the neuroscience research community for their use and modification. Investigative studies should be limited to model parameter estimation and/or validity testing of the tools being developed.","Research Project Grants","Integrated Approaches, Theory & Data Analysis Tools","Understanding Circuits","Human Neuroscience, Systems Neuroscience"
"BRAIN Initiative: Engineering and optimization of molecular technologies for functional dissection of neural circuits (UM1 Clinical Trial Not Allowed)",RFA-MH-22-245,http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-22-245.html,Closed,2024-10-18,"This BRAIN Initiative FOA is to further develop molecular tools of high impact that are targetable to brain cell types for the monitoring and manipulation of neural circuits in experimental animals. This FOA is part of the BRAIN Initiative Armamentarium for Brain Cell Access transformative project. This will support iterative improvement of molecular payloads capable of monitoring and manipulating neural cell activity and that can be delivered to specific brain cell types using targeting technologies.","Cooperative Agreements","Cell Type, Circuit Diagrams, Monitor Neural Activity",Armamentarium,"Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative: Brain Behavior Quantification and Synchronization (R61/R33 Clinical Trial Optional)",RFA-MH-22-240,https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-22-240.html,Closed,2022-12-23,"This Funding Opportunity Announcement (FOA) supports the development and validation of next-generation tools, methods, and analytic approaches to precisely quantify behaviors and combine them with simultaneous recordings of brain activity in humans. Tools used for measuring and analyzing behavior should be multi-modal, with the appropriate accuracy, specificity, temporal resolution, and flexibility necessary for integration with existing tools used to measure and modulate the brain circuits that give rise to those behaviors.","Research Project Grants","Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools","BBQS, Investigative Human Neuroscience","Human Neuroscience, Neural Recording & Modulation"
"BRAIN Initiative: Transformative Brain Non-invasive Imaging Technology Development (UG3/UH3 Clinical Trial Not Allowed)",RFA-EB-22-001,https://grants.nih.gov/grants/guide/rfa-files/RFA-EB-22-001.html,Closed,2023-01-06,"This Funding Opportunity Announcement (FOA) solicits applications for team-centric development and validation of innovative non-invasive imaging technologies that could have a transformative impact on the study of brain function/connectivity. Applications are expected to turn a novel concept into a functional prototype using this phased grant mechanism. The feasibility should be established by the end of its first phase and serve as a foundation for the transition to its second phase. Fully developing the technology into a functional prototype and validating it by in-vivo animal or human function/connectivity imaging are anticipated in the second phase. The research plan should provide a realistic timeline and tangible milestones to support the proposed development effort. Awards will be integrated into the BRAIN Non-Invasive Imaging Consortium, as a coordinated network on brain function/connectivity imaging.","Cooperative Agreements","Circuit Diagrams, Human Neuroscience, Monitor Neural Activity","Investigative Human Neuroscience","Neuroimaging Technologies Across Scales"
"BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP (U19 Basic Experimental Studies with Humans Required)",RFA-NS-22-039,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-22-039.html,Closed,2024-09-14,"This FOA will support integrated, interdisciplinary research teams from prior BRAIN technology and/or integrated approaches teams, and/or new projects from the research community that focus on examining circuit functions related to behavior, using advanced and innovative technologies. The goal will be to support programs with a team science approach that can realize meaningful outcomes within 5-plus years. Awards will be made for 5 years, with a possibility of one competing renewal. Applications should address overarching principles of circuit function in the context of specific neural systems underlying sensation, perception, emotion, motivation, cognition, decision-making, motor control, communication, or homeostasis. Applications should incorporate theory-/model-driven experimental design and should offer predictive models as deliverables. Applications should seek to understand circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating relevant dynamic patterns of neural activity and by measuring the resulting behaviors and/or perceptions. Applications are expected to employ approaches guided by specified theoretical constructs, and are encouraged to employ quantitative, mechanistic models where appropriate. Applications will be required to manage their data and analysis methods in a prototype framework that will be developed and used in the proposed U19 project and exchanged with other U19 awardees for further refinement and development. Model systems, including the possibility of multiple species ranging from invertebrates to humans, can be employed and should be appropriately justified. Budgets should be commensurate with multi-component teams of research expertise including neurobiologists, statisticians, physicists, mathematicians, engineers, computer scientists, and data scientists, as appropriate - that seek to cross boundaries of interdisciplinary collaboration.","Cooperative Agreements","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Theory & Data Analysis Tools","Investigative Human Neuroscience, Understanding Circuits","Human Neuroscience, Systems Neuroscience"
"BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP (U19 Clinical Trial Not Allowed)",RFA-NS-22-040,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-22-040.html,Closed,2024-09-14,"This FOA will support integrated, interdisciplinary research teams that focus on examining dynamic circuit functions related to behavior, using advanced and innovative technologies. The FOA will support programs with a necessarily-synergistic, team science approach. Awards will be made for 5 years, with a possibility of one competing renewal. Applications should incorporate overarching principles of circuit function in the context of specific neural systems underlying sensation, perception, emotion, motivation, cognition, decision-making, motor control, communication, or homeostasis. Applications should incorporate theory-/model-driven experimental design and should offer predictive models as deliverables. Applications should seek to understand circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating relevant dynamic patterns of neural activity and by measuring the resulting behaviors and/or perceptions. Applications are expected to employ approaches guided by specified theoretical constructs, and are encouraged to employ quantitative, mechanistic models where appropriate. Applications will be required to manage their data and analysis methods in a framework that will be developed and used in the proposed U19 project and exchanged with other BRAIN U19 awardees for further refinement and development. Model systems, including the possibility of multiple species ranging from invertebrates to humans, can be employed and should be appropriately justified. Programs should employ multi-component teams of research expertise including neurobiologists, statisticians, physicists, mathematicians, engineers, computer scientists, and data scientists, as appropriate - that seek to cross boundaries of interdisciplinary collaboration. Applicants proposing to include human subjects with invasive neural recording must apply to the companion FOA, RFA-NS-XX-XXX.","Cooperative Agreements","Cell Type, Circuit Diagrams, Integrated Approaches, Theory & Data Analysis Tools","Understanding Circuits","Systems Neuroscience"
"BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (U01 Basic Experimental Studies with Humans Required)",RFA-NS-22-041,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-22-041.html,Closed,2024-09-22,"This FOA will support integrated, interdisciplinary research teams that focus on examining dynamic circuit functions related to behavior, using advanced and innovative technologies. The FOA will support programs with a necessarily-synergistic, team science approach. Awards will be made for 5 years, with a possibility of one competing renewal. Applications should focus on overarching principles of circuit function in the context of specific neural systems underlying sensation, perception, emotion, motivation, cognition, decision-making, motor control, communication, or homeostasis. Applications should aim to understand these circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating relevant dynamic patterns of neural activity and by measuring the resulting behaviors and/or perceptions. Applications are expected to employ approaches and experimental design guided by specified theoretical constructs, are encouraged to employ quantitative, mechanistic and predictive models where appropriate. Model systems, including the possibility of multiple species ranging from invertebrates to humans, can be employed and should be appropriately justified. Programs should employ multi-component teams of research expertise including neurobiologists, statisticians, physicists, mathematicians, engineers, computer scientists, and data scientists, as appropriate - that seek to cross boundaries of interdisciplinary collaboration. Applications will be required to manage their data and analysis methods in a framework that will be developed and used in the proposed U19 project and exchanged with other BRAIN U19 awardees for further refinement and development.","Cooperative Agreements","Human Neuroscience, Monitor Neural Activity","Investigative Human Neuroscience","Human Neuroscience, Systems Neuroscience"
"BRAIN Initiative: Integration and Analysis of BRAIN Initiative Data (R01 Clinical Trial Not Allowed)",RFA-MH-22-220,http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-22-220.html,Closed,2024-06-08,"This is a reissue of RFA-MH-21-135. This FOA supports the development of software to visualize and analyze the data as part of programs of building the informatics infrastructure for the BRAIN Initiative. Other informatics programs include developing data standards that are needed to describe the new experiments that are being created by or used in the BRAIN Initiative ( RFA-MH-19-146 ), and creating the data infrastructures that will house the data from multiple experimental groups ( RFA-MH-19-145 ). Each of the programs is aimed at building an infrastructure that is used by a particular sub-domain of experimentalists rather than building a single all-encompassing informatics infrastructure now. Building the infrastructure one experimental area at a time will ensure that the infrastructure is immediately useful to components of the research community. As our understanding of the brain improves, it may be possible to create linkages between these various sub-domain specific informatics programs. Investigators of the informatics programs should keep that goal in mind and build for the future even though the current efforts are more limited in scope.","Research Project Grants","Integrated Approaches, Theory & Data Analysis Tools",Informatics,"Data Science & Informatics"
"BRAIN Initiative:  Exploratory Team-Research BRAIN Circuit Programs - eTeamBCP (U01 Clinical Trials Optional)",RFA-NS-22-028,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-22-028.html,Closed,2024-06-15,"Reissue of:RFA-NS-18-029 and RFA-NS-20-029. This funding opportunity announcement (FOA) is designed to support teams of investigators that seek to cross boundaries of interdisciplinary collaboration to elucidate the contributions of dynamic circuit activity to a specific behavioral or neural system. Applications are encouraged to propose adventurous and challenging goals that can only be tackled by a synergistic team-based approach and have the potential to be transformative and/or to enable significant advances. These studies at the exploratory stage are intended for the development of experimental capabilities and/or theoretical frameworks in preparation for a future competition for larger-scale or extended efforts, including the BRAIN TargetedBCP R01 or the multi-component, Team-Research BRAIN Circuit Programs (U19).The overall goal of this FOA is to enable a large-scale analysis of neural systems and circuits within the context and during the simultaneous measurement of an ethologically relevant behavior. Toward this end, teams are expected to assemble and leverage multi-disciplinary expertise, and to integrate experimental with computational and theoretical approaches. Teams are expected to bridge fields by incorporating rich information on cell-types, on circuit functionality and connectivity, in conjunction with sophisticated analyses of an ethologically relevant behavior of an organism or a well-defined neural system. Teams are also expected to aim for a mechanistic understanding of the circuits of the central nervous system (CNS) by applying cutting-edge methods such as those for large-scale recording, manipulation, and analysis of neural circuits across multiple regions of the CNS.","Cooperative Agreements","Circuit Diagrams, Integrated Approaches","Understanding Circuits","Systems Neuroscience"
"BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Comprehensive Centers for Human and Non-Human Primate Brain (UM1 Clinical Trial Not Allowed)",RFA-NS-22-047,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-22-047.html,Closed,2023-06-14,"This Funding Opportunity Announcement (FOA) supports Comprehensive Centers to develop and test technologies that can be scaled to brain-wide atlases of human and non-human primate circuit connectivity. Centers will establish data collection, analysis, and dissemination pipelines to demonstrate the feasibility of mapping region-to-region connectivity with a minimum resolution of individual cells and/or axon fibers. They will demonstrate the significance of the approach within the context of a chosen CNS sub-volume, by testing specific hypotheses relating circuit structure to function. They will also incorporate toolsets and infrastructure for integrating separately collected data from smaller volumes, as well as from other data collection modalities, and for enabling the neuroscience community to interact with and mine the data for new research questions. Centers will be integrated into the BRAIN CONNECTS Network, consisting of projects from this FOA and its companion announcements, as a coordinated effort aimed at developing wiring diagrams that can span entire brains across multiple scales.","Cooperative Agreements","Cell Type, Circuit Diagrams, Theory & Data Analysis Tools","BRAIN CONNECTS, Understanding Circuits","Human Neuroscience, Neuroimaging Technologies Across Scales"
"BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Comprehensive Centers for Mouse Brain (UM1 Clinical Trial Not Allowed)",RFA-NS-22-048,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-22-048.html,Closed,2023-06-14,"This Funding Opportunity Announcement (FOA) supports Comprehensive Centers to develop and test technologies that can be scaled to brain-wide atlases of mouse circuit connectivity. Centers will establish data collection, analysis, and dissemination pipelines to demonstrate the feasibility of mapping cell-to-cell connectivity with a minimum resolution of synaptic connections. They will demonstrate the significance of the approach within the context of a chosen CNS sub-volume, by testing specific hypotheses relating circuit structure to function. They will also incorporate toolsets and infrastructure for integrating separately collected data from smaller volumes, as well as from other data collection modalities, and for enabling the neuroscience community to interact with and mine the data for new research questions. Centers will be integrated into the BRAIN CONNECTS Network, consisting of projects from this FOA and its companion announcements, as a coordinated effort aimed at developing wiring diagrams that can span entire brains across multiple scales.","Cooperative Agreements","Cell Type, Circuit Diagrams, Theory & Data Analysis Tools","BRAIN CONNECTS, Understanding Circuits","Neuroimaging Technologies Across Scales"
"BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Specialized Projects for Scalable Technologies (U01 Clinical Trial Not Allowed)",RFA-NS-22-049,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-22-049.html,Closed,2024-06-14,"This Funding Opportunity Announcement (FOA) supports Specialized Projects to develop current or emerging technologies to generate comprehensive atlases of brain connectivity, with an emphasis on human, non-human primate (NHP), and mouse. Projects validating approaches using other species are also permitted if well justified. Applications may address any aspects of the data collection, analysis, and dissemination pipelines, to enable faster and more cost-effective generation and interpretation of brain-wide wiring diagrams. Projects will offer distinct capabilities and competencies aimed at developing and optimizing current technologies or entirely new and potentially risky approaches. They will be integrated into the BRAIN CONNECTS Network, consisting of other Specialized Projects from this FOA, and Comprehensive Centers from its companion announcements, as a coordinated effort aimed at developing wiring diagrams that can span entire brains across multiple scales.","Cooperative Agreements","Cell Type, Circuit Diagrams, Theory & Data Analysis Tools","BRAIN CONNECTS, Understanding Circuits","Neuroimaging Technologies Across Scales"
"BRAIN Initiative: Targeted BRAIN Circuits Projects- TargetedBCP (R01 Clinical Trial Not Allowed)",RFA-NS-22-026,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-22-026.html,Closed,2024-10-03,"(Reissue of RFA-NS-18-030) This FOA solicits applications for research projects that use innovative, methodologically-integrated approaches to understand how circuit activity gives rise to mental experience and behavior. The goal is to support projects that can realize a meaningful outcome within 5 years. Applications should address circuit function in the context of specific neural systems such as sensation, perception, attention, reasoning, intention, decision-making, emotion, navigation, communication or homeostasis. Projects should link theory and data analysis to experimental design and should produce predictive models as deliverables. Projects should aim to improve the understanding of circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating dynamic patterns of neural activity. Projects can use non-human and human species, and applications should explain how the selected species offers ideal conditions for revealing general principles about the circuit basis of a specific behavior.","Research Project Grants","Cell Type, Circuit Diagrams, Integrated Approaches","Understanding Circuits","Systems Neuroscience"
"BRAIN Initiative: Targeted BRAIN Circuits Planning Projects  TargetedBCPP (R34 Clinical Trials Not Allowed)",RFA-NS-22-027,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-22-027.html,Closed,2024-10-03,"(Reissue of RFA-NS-18-014 and RFA-NS-21-014) This R34 FOA solicits applications that offer a limited scope of aims and an approach that will establish feasibility, validity, or other technically qualifying results that, if successful, would support, enable, and/or lay the groundwork for a potential, subsequent Targeted Brain Circuits Projects - TargetedBCP R01, as described in the companion FOA (RFA-NS-22-026). Applications should be exploratory research projects that use innovative, methodologically-integrated approaches to understand how circuit activity gives rise to mental experience and behavior.","Research Project Grants","Circuit Diagrams, Integrated Approaches, Monitor Neural Activity","Understanding Circuits","Systems Neuroscience"
"BRAIN Initiative: Development of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in Human and Non-Human Primate Brain (UG3/UH3 Clinical Trial Optional)",RFA-MH-22-115,http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-22-115.html,Closed,2024-06-08,"Reissue of RFA-MH-19-135 The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis and manipulation of complex circuits and provide insights into cellular interactions that underlie brain function. Critical advances in the treatment of brain disorders in human populations are hindered by our lack of ability to monitor and manipulate circuitry in safe, minimally-invasive ways. Clinical intervention with novel cell and circuit specific tools will require extensive focused research designed to remove barriers to delivery of gene therapies. In addition to identification and removal of barriers, the need to specifically target dysfunctional circuitry poses additional challenges. Neuroscience has experienced an impressive influx of exciting new research tools in the past decade, especially since the launch of the BRAIN Initiative. However, the majority of these cutting edge tools have been developed for use in model organisms, primarily rodents, fish and flies. These cutting edge tools, such as viral delivery of genetic constructs, are increasingly adaptable to large brains and more importantly are emerging as potential human therapeutic strategies for brain disorders. A pressing need to develop tools for use in large brains, more directly relevant to the human brain is the focus of this initiative. The new tools and technologies should inform and/or exploit cell-type and/or circuit-level specificity. Plans for validating the utility of the tool/technology will be an essential feature of a successful application. The development of new genetic and non-genetic tools for delivering genes, proteins and chemicals to cells of interest or approaches that are expected to target specific cell types and/or circuits in the nervous system with greater precision and sensitivity than currently established methods are encouraged.","Cooperative Agreements","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools","Understanding Circuits","Human Neuroscience, Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative: Standards to Define Experiments Related to the BRAIN Initiative (R01 Clinical Trial Not Allowed)",RFA-MH-22-145,http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-22-145.html,Closed,2024-06-15,"Reissue of RFA-MH-20-128 This Funding Opportunity Announcement (FOA) solicits applications to develop standards that describe experimental protocols that are being conducted as part of the BRAIN Initiative. It is expected that applications will solicit community input at all stages of the process. It is recommended that the first step of standard development will involve sharing data between different key groups in the experimental community in order to ensure that the developing standard will cover the way that all of those groups are collecting data. The developed standard is expected to be made widely available.","Research Project Grants","Theory & Data Analysis Tools",Informatics,"Data Science & Informatics"
"Notice of Special Interest (NOSI): BRAIN Initiative: Translation of Groundbreaking Technologies from Early-stage Development through Early Clinical Study via Blueprint MedTech",NOT-NS-22-052,http://grants.nih.gov/grants/guide/notice-files/NOT-NS-22-052.html,Closed,2024-06-21,"This Notice of Special Interest (NOSI) encourages the translation of the novel neurotechnologies, funded through the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative and overseen by the NIH Blueprint MedTech program. Academic and Small Business Concerns (SBCs) are encouraged to submit grant applications that propose non-clinical validation for subsequent clinical feasibility studies. Applications supporting the development and translation of groundbreaking neurotechnologies that fit within the mission of the BRAIN Initiative are encouraged.",,,,
"BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed)",RFA-NS-22-011,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-22-011.html,Closed,2023-04-17,"This funding opportunity announcement (FOA) supports efforts to disseminate resources and to integrate them into neuroscience research practice. Projects should be highly relevant to specific goals of the BRAIN Initiative, goals that are described in the planning document ""BRAIN 2025: A Scientific Vision."" They should engage in one or more of the following activities: distribution of tools and reagents; user training on the usage of new technologies or techniques; providing access to existing technology platforms and specialized facilities; minor improvements to increase the scale/efficiency of resource production and delivery; minor adaptations to meet the needs of a user community. Applications strictly focused on technology or software development, rather than dissemination of an existing resource, are not responsive to this FOA. Refinements to microscopes or tools necessary to customize them to the experimental needs of the end users is allowed. Projects should address compelling needs of neuroscience researchers working toward the goals of the BRAIN 2025 report that are otherwise unavailable or impractical in their current form.","Cooperative Agreements","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools",Dissemination,Dissemination
"Notice of Special Interest (NOSI): Administrative Supplements for Embedded Ethicists into BRAIN Initiative Supported Research",NOT-MH-22-040,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-22-040.html,Closed,2022-04-02,"The purpose of this Notice of Special Interest (NOSI) is to encourage applications to PA-20-272 to integrate neuroethics perspectives and approaches into existing BRAIN Initiative awards.",,,,
"BRAIN Initiative Cell Atlas Network (BICAN): Comprehensive Center on Human and Non-human Primate Brain Cell Atlases (UM1 Clinical Trial Not Allowed)",RFA-MH-21-235,https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-21-235.html,Closed,2021-11-10,"This Funding Opportunity Announcement (FOA) intends to support a group of large-scale Comprehensive Centers that will adopt scalable technology platforms and streamlined sampling strategies and assay cascade to create comprehensive and highly granular brain cell atlases of human and non-human primates with an emphasis on human. The Centers are expected to characterize all brain cell types (neurons, glia, and other non-neuronal cells) at high-resolution. The overarching goal of the BICAN is to build reference brain cell atlases that will be widely used throughout the research community, providing a molecular and anatomical foundational framework for the study of brain function and disorders.","Cooperative Agreements","Cell Type, Circuit Diagrams",BICAN,"Human Neuroscience, Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative Cell Atlas Network (BICAN): Specialized Collaboratory on Human, Non-human Primate, and Mouse Brain Cell Atlases (U01 Clinical Trial Not Allowed)",RFA-MH-21-236,https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-21-236.html,Closed,2021-11-10,"This Funding Opportunity Announcement (FOA) intends to support a group of Specialized Collaboratories that will adopt scalable technology platforms and streamlined sampling strategies and assay cascade to create comprehensive and highly granular brain cell atlases in human, non-human primates, and mouse, in coordination and collaboration with other BICAN projects. In particular, the Specialized Collaboratories are expected to complement the Comprehensive Centers in BICAN with distinct capabilities, competencies, and research aims. The overarching goal of the BICAN is to build reference brain cell atlases that will be widely used throughout the research community, providing a molecular and anatomical foundational framework for the study of brain function and disorders.","Cooperative Agreements","Cell Type, Circuit Diagrams",BICAN,"Human Neuroscience, Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative Cell Atlas Network (BICAN): Coordinating Unit for Biostatistics, Informatics, and Engagement (CUBIE) (U24 Clinical Trial Not Allowed)",RFA-MH-21-237,https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-21-237.html,Closed,2021-11-10,"This Funding Opportunity Announcement (FOA) intends to support a Coordinating Unit for Biostatistics, Informatics, and Engagement (CUBIE) that will be composed of four components to establish respectively (1) a common sequencing data processing pipeline, (2) a common imaging data processing pipeline, (3) a comprehensive brain cell knowledge base, and (4) an engaging and outreach component to coordinate the research within and beyond BICAN. The overall goals of CUBIE are to (i) enable the exploration of large-scale brain cell atlas data and knowledge, and inspire research in brain function and disorders; and (ii) ensure research rigor and data reproducibility by making the data to be findable, accessible, interoperable, and reusable, and the process transparent. An application is expected to propose only one of the above four respective components.","Cooperative Agreements","Cell Type, Circuit Diagrams",BICAN,"Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative: Research on the Ethical Implications of Advancements in Neurotechnology and Brain Science (R01 Clinical Trial Optional)",RFA-MH-21-205,http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-21-205.html,Closed,2023-10-12,"Reissue of RFA-MH-19-400. This funding opportunity announcement (FOA), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, is one of several FOAs aimed at supporting transformative discoveries that will lead to breakthroughs in understanding human brain function. Guided by the long-term scientific plan, BRAIN 2025: A Scientific Vision, this FOA specifically seeks to support efforts addressing core ethical issues associated with research focused on the human brain and resulting from emerging technologies and advancements supported by the BRAIN Initiative. The hope is that efforts supported under this FOA might be both complementary and integrative with the transformative, breakthrough neuroscience discoveries supported through the BRAIN Initiative.","Research Project Grants","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools",Neuroethics,Neuroethics
"PHS 2021-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)",PA-21-259,https://grants.nih.gov/grants/guide/pa-files/PA-21-259.html,Closed,2022-04-06,"The Notice of Special Interest (NOSI): Translation of BRAIN Initiative Technologies to the Marketplace, NOT-MH-21-125, encourages the translation of BRAIN Initiative-supported technologies from academic and other non-small business research sectors to the marketplace. Small Business Concerns (SBCs) are encouraged to submit Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) grant applications that propose to further develop, optimize, validate and scale such technologies for commercial dissemination. Submit applications for this initiative using one of the following funding opportunity announcements (FOAs) or any reissues of these announcement through the expiration date (January 6, 2024) of NOT-MH-21-125: PA-21-259 (SBIR Omnibus/Parent Clinical Trial Not Allowed) and PA-21-262 (STTR Omnibus/Parent Clinical Trial Not Allowed). ","Small Business Grants","Circuit Diagrams, Interventional Tools, Monitor Neural Activity","Dissemination, Public-Private Partnerships",Dissemination
"PHS 2021-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)",PA-21-262,https://grants.nih.gov/grants/guide/pa-files/PA-21-262.html,Closed,2022-04-06,"The Notice of Special Interest (NOSI): Translation of BRAIN Initiative Technologies to the Marketplace, NOT-MH-21-125, encourages the translation of BRAIN Initiative-supported technologies from academic and other non-small business research sectors to the marketplace. Small Business Concerns (SBCs) are encouraged to submit Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) grant applications that propose to further develop, optimize, validate and scale such technologies for commercial dissemination. Submit applications for this initiative using one of the following funding opportunity announcements (FOAs) or any reissues of these announcement through the expiration date (January 6, 2024) of NOT-MH-21-125: PA-21-259 (SBIR Omnibus/Parent Clinical Trial Not Allowed) and PA-21-262 (STTR Omnibus/Parent Clinical Trial Not Allowed). ","Small Business Grants","Circuit Diagrams, Interventional Tools, Monitor Neural Activity","Dissemination, Public-Private Partnerships",Dissemination
"BRAIN Initiative: New Technologies and Novel Approaches for Recording and Modulation in the Nervous System (R01 Clinical Trial Not Allowed)",RFA-NS-21-026,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-21-026.html,Closed,2023-10-28,"Reissue of RFA-NS-18-020: Understanding the dynamic activity of brain circuits is central to the NIH BRAIN Initiative. This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS). This FOA seeks exceptionally creative approaches to address major challenges associated with recording and modulating CNS activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain. It is expected that the proposed research may be high-risk, but if successful, could profoundly change the course of neuroscience research. Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS. Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, magnetic, acoustic and/or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.","Research Project Grants","Interventional Tools",,"Human Neuroscience, Neural Recording & Modulation"
"BRAIN Initiative: Optimization of Transformative Technologies for Recording and Modulation in the Nervous System (U01 Clinical Trials Not Allowed)",RFA-NS-21-027,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-21-027.html,Closed,2023-10-28,"Reissue of RFA-NS-18-019: Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative. The invention, proof-of-concept investigation, and optimization of new technologies through iterative feedback from end users are key components of the BRAIN Initiative. This FOA seeks applications to optimize existing or emerging technologies through iterative testing with end users. The technologies and approaches should have potential to address major challenges associated with recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS). These technologies and approaches should have previously demonstrated their transformative potential through initial proof-of-concept testing and are now ready for accelerated refinement. In conjunction, the manufacturing techniques should be scalable towards sustainable, broad dissemination and user-friendly incorporation into regular neuroscience research. Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS. Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, electrical, magnetic, acoustic or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.","Cooperative Agreements","Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools","Investigative Human Neuroscience, Understanding Circuits","Human Neuroscience, Neural Recording & Modulation"
"BRAIN Initiative:  Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UG3/UH3 Clinical Trial Optional)",RFA-NS-21-023,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-21-023.html,Closed,2024-02-21,"The purpose of this Funding Opportunity Announcement (FOA) is to encourage investigators to pursue translational activities and small clinical studies to advance the development of therapeutic, and diagnostic devices for disorders that affect the nervous or neuromuscular systems. Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, obtaining an Investigational Device Exemption (IDE) for a Significant Risk (SR) study, as well as a subsequent small clinical study. The clinical study is expected to provide information about the device function or final design that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. This FOA is a milestone-driven cooperative agreement program and will involve participation of NIH program staff in negotiating the final project plan before award and monitoring of research progress.","Cooperative Agreements","Human Neuroscience, Interventional Tools, Monitor Neural Activity","Public-Private Partnerships, Therapeutic Human Neuroscience","Human Neuroscience, Neural Recording & Modulation"
"BRAIN Initiative: Clinical Studies to Advance Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UH3 Clinical Trial Optional)",RFA-NS-21-024,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-21-024.html,Closed,2024-02-21,"The purpose of this Funding Opportunity Announcement (FOA) is to encourage investigators to pursue a small clinical trial to obtain critical information necessary to advance recording and/or stimulating devices to treat central nervous system disorders and better understand the human brain (e.g., Early Feasibility Study). Clinical studies supported may consist of acute or short-term procedures that are deemed Non-Significant Risk (NSR) by an Institutional Review Board (IRB), or Significant Risk (SR) studies that require an Investigational Device Exemption (IDE) from the FDA, such as chronic implants. The clinical trial should provide data to answer key questions about the function or final design of a device. This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval. The clinical trial is expected to provide information that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. Activities supported by this Funding Opportunity include a small clinical trial to answer key questions about the function or final design of a device. As part of the BRAIN Initiative, NIH has initiated a Public-Private Partnership Program (BRAIN PPP) that includes agreements (Memoranda of Understanding, MOU) with a number of device manufacturers willing to make such devices available, including devices and capabilities not yet market approved but appropriate for clinical research. In general it is expected that the devices' existing safety and utility data will be sufficient to enable new IRB NSR or FDA IDE approval without need for significant additional non-clinical data. For more information on the BRAIN PPP, see http://braininitiative.nih.gov/BRAIN_PPP/index.htm","Cooperative Agreements","Human Neuroscience, Interventional Tools, Monitor Neural Activity","Public-Private Partnerships, Therapeutic Human Neuroscience","Human Neuroscience, Neural Recording & Modulation"
"BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed)",RFA-MH-21-175,http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-21-175.html,Closed,2023-10-07,"This is a reissue of RFA-MH-19-136. The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function. The new tools and technologies should inform and/or exploit cell-type and/or circuit-level specificity. Plans for validating the utility of the tool/technology will be an essential feature of a successful application. The development of new genetic and non-genetic tools for delivering genes, proteins and chemicals to cells of interest or approaches that are expected to target specific cell types and/or circuits in the nervous system with greater precision and sensitivity than currently established methods are encouraged. Tools that can be used in a number of species/model organisms rather than those restricted to a single species are highly desired. Applications that provide approaches that break through existing technical barriers to substantially improve current capabilities are highly encouraged.","Research Project Grants","Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity",,"Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative: Reagent Resources for Brain Cell Type-Specific Access and Manipulation to Broaden Distribution of Enabling Technologies for Neuroscience (U24 Clinical Trial Not Allowed)",RFA-MH-21-180,http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-21-180.html,Closed,2023-10-24,"This Funding Opportunity Announcement (FOA) from the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is intended to support establishment of facilities at minority-serving institutions (MSIs) and Institutional Development Award (IDeA)-eligible institutions for scaled production and distribution of brain cell type-specific access and manipulation reagents. Reagents will be initially developed in pilot resource projects for brain cell type-specific access and manipulation across vertebrate species from the BRAIN Initiative Armamentarium project. Awardees under this FOA will work with the other Armamentarium awardees to manufacture and distribute the resources for use throughout the neuroscience community. It is envisioned that the awardees will work both with the Armamentarium community as well as with the neuroscience research community to optimize the use of new reagents. The types of reagents to be produced and distributed could include but are not limited to viral vectors, nucleic acid constructs, and nanoparticles designed for selective access to and manipulation of brain cell types. Such reagents will enable neuroscientists to probe circuit function with high precision in experimental animals and ex vivo human tissue and cells. Facilities are needed to contribute to the production and distribution of BRAIN Initiative Armamentarium project reagents broadly to neuroscience users.","Cooperative Agreements","Cell Type, Monitor Neural Activity",Armamentarium,"Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative: Targeted BRAIN Circuits Projects- TargetedBCP (R01 Clinical Trial Not Allowed)",RFA-NS-21-013,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-21-013.html,Closed,2021-11-11,"(Reissue of RFA-NS-18-030) This FOA solicits applications for research projects that use innovative, methodologically-integrated approaches to understand how circuit activity gives rise to mental experience and behavior. The goal is to support projects that can realize a meaningful outcome within 5 years. Applications should address circuit function in the context of specific neural systems such as sensation, perception, attention, reasoning, intention, decision-making, emotion, navigation, communication or homeostasis. Projects should link theory and data analysis to experimental design and should produce predictive models as deliverables. Projects should aim to improve the understanding of circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating dynamic patterns of neural activity.  Projects can use non-human and human species, and applications should explain how the selected species offers ideal conditions for revealing general principles about the circuit basis of a specific behavior.","Research Project Grants","Integrated Approaches, Circuit Diagrams","Understanding Circuits","Systems Neuroscience"
"BRAIN Initiative: Targeted BRAIN Circuits Planning Projects  TargetedBCPP (R34 Clinical Trials Not Allowed)",RFA-NS-21-014,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-21-014.html,Closed,2021-11-11,"(Reissue of RFA-NS-18-014) This R34 FOA solicits applications that offer a limited scope of aims and an approach that will establish feasibility, validity, or other technically qualifying results that, if successful, would support, enable, and/or lay the groundwork for a potential, subsequent Targeted Brain Circuits Projects - TargetedBCP R01, as described in the companion FOA (RFA-NS-18-009). Applications should be exploratory research projects that use innovative, methodologically-integrated approaches to understand how circuit activity gives rise to mental experience and behavior.","Research Project Grants","Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","Understanding Circuits","Systems Neuroscience"
"BRAIN Initiative: Secondary Analysis and Archiving of BRAIN Initiative Data (R01 Clinical Trial Not Allowed)",RFA-MH-21-130,https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-21-130.html,Closed,2021-10-08,"This is a reissue of RFA-MH-20-120. This FOA invites applications that will conduct secondary analysis or data mining of existing data relevant to the BRAIN Initiative goal of understanding brain circuits. The FOA also invites applications that seek to prepare and submit existing data that are highly relevant to the BRAIN Initiative into one of the BRAIN Initiative data archives. Applications can propose to generate or test new hypotheses which would not be possible in studies of single experiments, single technologies or single laboratories, or were beyond the scope of the original studies. Applications that propose to reanalyze existing data sets using new tools or approaches are also welcome. The proposed research may involve innovative analyses of existing data or novel combination or integration of existing data sets to address new aims or explore new questions.","Research Project Grants","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools",Informatics,"Data Science & Informatics"
"BRAIN Initiative: Integration and Analysis of BRAIN Initiative Data (R01 Clinical Trial Not Allowed)",RFA-MH-21-135,https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-21-135.html,Closed,2022-03-22,"This Funding Opportunity Announcement (FOA) solicits applications to develop informatics tools for analyzing, visualizing, and integrating data related to the BRAIN Initiative or to enhance our understanding of the brain. As part of programs of building the informatics infrastructure for the BRAIN Initiative, the FOA supports several different, but related activities. These include modifying existing analysis and visualization tools to deal with BRAIN Initiative data and integrating different types of BRAIN Initiative datasets. Proposing the development of new tools to deal with BRAIN Initiative data is also permitted. The tools supported under this FOA will make use of relevant data standards and will be built so that they can be integrated into the data repositories, both of which are created in awards under the other FOAs of the BRAIN initiative informatics program. The tools must be user-friendly in accessing and analyzing data from appropriate data archives, and should analyze/visualize data without requiring users to download data. The tools should also allow data to be combined for analysis/visualization from multiple locations.","Research Project Grants","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools",Informatics,"Data Science & Informatics"
"Notice of Special Interest (NOSI): Translation of BRAIN Initiative Technologies to the Marketplace",NOT-MH-21-125,http://grants.nih.gov/grants/guide/notice-files/NOT-MH-21-125.html,Closed,2024-01-06,"This Notice of Special Interest (NOSI) encourages the translation of BRAIN Initiative technologies from academic and other non-small business research sectors to the marketplace. Small Business Concerns (SBCs) are encouraged to submit Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) grant applications that propose to further develop, optimize, validate and scale such technologies for commercial dissemination. Additionally, SBIR and STTR applications supporting the development and commercialization of novel technologies that fit within the mission of the BRAIN Initiative are encouraged.",,,,
"BRAIN Initiative: New Concepts and Early-Stage Research for Recording and Modulation in the Nervous System (R21) (Clinical Trial Not Allowed)",RFA-EY-21-001,http://grants.nih.gov/grants/guide/rfa-files/RFA-EY-21-001.html,Closed,2023-10-28,"A central goal of the BRAIN Initiative is to understand how electrical and chemical signals code information in neural circuits and give rise to sensations, thoughts, emotions and actions. While currently available technologies can provide some understanding, they may not be sufficient to accomplish this goal. For example, non-invasive technologies are low resolution and/or provide indirect measures such as blood flow, which are imprecise; invasive technologies can provide information at the level of single neurons producing the fundamental biophysical signals, but they can only be applied to tens or hundreds of neurons, out of a total number in the human brain estimated at 85 billion. Other BRAIN FOAs seek to develop novel technology (RFA-NS-17-003) or to optimize existing technology ready for in-vivo proof-of-concept testing and collection of preliminary data (RFA-NS-17-004) for recording or manipulating neural activity on a scale that is beyond what is currently possible. This FOA seeks applications for unique and innovative technologies that are in an even earlier stage of development than that sought in other FOAs, including new and untested ideas that are in the initial stages of conceptualization. In addition to experimental approaches, the support provided under this FOA might enable calculations, simulations, computational models, or other mathematical techniques for demonstrating that the signal sources and/or measurement technologies are theoretically capable of meeting the demands of large-scale recording or manipulation of circuit activity in humans or in animal models. The support might also be used for building and testing phantoms, prototypes, in-vitro or other bench-top models in order to validate underlying theoretical assumptions in preparation for future FOAs aimed at testing in animal models.","Research Project Grants","Interventional Tools, Monitor Neural Activity",,"Human Neuroscience, Neural Recording & Modulation"
"BRAIN Initiative Cell Census Network (BICCN) Scalable Technologies and Tools for Brain Cell Census (R01 Clinical Trial Not Allowed)",RFA-MH-21-140,https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-21-140.html,Closed,2021-03-11,"Reissue of RFA-MH-19-148. This Funding Opportunity Announcement (FOA) intends to accelerate the integration and use of scalable technologies and tools to enhance brain cell census research, including the development of technology platforms and/or resources that will enable a swift and comprehensive survey of brain cell types and circuits. Applications are expected to address limitations and gaps of existing technologies/tools as a benchmark against which the improvements or competitive advantages of the proposed ones will be measured. The improvements include throughput, sensitivity, selectivity, scalability, spatiotemporal resolution and reproducibility in cell census analyses. The projects funded under this FOA will align with the overarching goals of The BRAIN Initiative® Cell Census Network (BICCN) and are expected to enable the generation of a substantial amount of cell census data using the proposed technologies or via collaboration with the BICCN.","Research Project Grants","Cell Type, Circuit Diagrams","Cell Census Network (BICCN)","Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative Fellows: Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (F32)",RFA-MH-20-620,https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-17-215.html,Closed,2022-12-10,"The purpose of the The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative Fellows (F32) program is to enhance the research training of promising postdoctorates, early in their postdoctoral training period, who have the potential to become productive investigators in research areas that will advance the goals of The BRAIN Initiative®. Applications are encouraged in any research area that is aligned with The BRAIN Initiative®, including neuroethics. Applicants are expected to propose research training in an area that clearly complements their predoctoral research. Formal training in analytical tools appropriate for the proposed research is expected to be an integral component of the research training plan. In order to maximize the training potential of the F32 award, this program encourages applications from individuals who have not yet completed their terminal doctoral degree and who expect to do so within 12 months of the application due date. On the application due date, candidates may not have completed more than 12 months of postdoctoral training.","Research Training & Fellowships","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools",Training,Training
"BRAIN Initiative: Pilot resources for brain cell type-specific access and manipulation across vertebrate species (U01 Clinical Trial Not Allowed)",RFA-MH-20-556,https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-20-556.html,Closed,2021-10-20,"This FOA is related to the transformative project, ""A Cell Type-Specific Armamentarium for Understanding Brain Function and Dysfunction,"" described in the ""The BRAIN Initiative® 2.0: From Cells to Circuits, Toward Cures"" report of the Advisory Committee to the NIH Director BRAIN Initiative Working Group 2.0.","Cooperative Agreements","Cell Type, Circuit Diagrams","Armamentarium, Understanding Circuits","Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative: Data Archives for the BRAIN Initiative (R24 Clinical Trial Optional)",RFA-MH-20-600,http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-20-600.html,Closed,2023-07-15,"This Funding Opportunity Announcement (FOA) solicits applications to develop web-accessible data archives to capture, store, and curate data related to BRAIN Initiative activities. The data archives will work with the research community to incorporate tools that allow users to analyze and visualize the data, but the creation of such tools is not part of this FOA. The data archives will use appropriate standards to describe the data, but the creation of such standards is not part of this FOA. A goal of this program is to advance research by creating a community resource data archive with appropriate standards and summary information that is broadly available and accessible to the research community for furthering research.","Research Project Grants","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools",Informatics,"Data Science & Informatics"
"BRAIN Initiative: Tools for Germline Gene Editing in Marmosets (U01 - Clinical Trial Not Allowed)",RFA-DA-21-006,https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-21-006.html,Closed,2022-10-15,"The purpose of this FOA isto develop tools and technologies to conduct cientifically rigorous, ethical, efficient, and cost-effective research infrastructure that supports germline and somatic transgenic and gene editing studies in the common marmoset (Callithrix jacchus). These studies should to answer crucial scientific questions that require genetic perturbation in a non-human primate model organism with the aim of supporting BRAIN goals of understanding the brain in health an disease.","Cooperative Agreements","Cell Type, Circuit Diagrams, Interventional Tools, Theory & Data Analysis Tools",,"Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative: Proof of Concept Development of Early Stage Next Generation Human Brain Imaging (R01 Clinical Trial Not Allowed)",RFA-EB-20-001,https://grants.nih.gov/grants/guide/rfa-files/RFA-EB-20-001.html,Closed,2021-09-04,"This funding opportunity announcement (FOA), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, aims to support early stage development of entirely new noninvasive imaging methods or unusually bold approaches for existing noninvasive imaging methods that will lead to transformative advances in our understanding of the function and connectivity of the human brain. The FOA solicits small-scale projects to prove exceptionally innovative, original and/or unconventional concepts.","Research Project Grants","Human Neuroscience, Interventional Tools, Monitor Neural Activity",,"Human Neuroscience, Neuroimaging Technologies Across Scales"
"BRAIN Initiative:  Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed)",RFA-EB-20-002,https://grants.nih.gov/grants/guide/rfa-files/RFA-EB-20-002.html,Closed,2021-09-15,"This FOA solicits the development of theories, computational models, and analytical tools to derive understanding of brain function from complex neuroscience data. Proposed tools could include tools to integrate existing theories or formulate new theories; conceptual frameworks to organize or fuse data to infer general principles of brain function; multiscale/multiphysics models to generate new testable hypotheses to design/drive future experiments; new analytical methods to either support or refute a stated hypothesis about brain function.. It is expected that the tools developed under this FOA will be made widely available to the neuroscience research community for their use and modification. Investigative studies should be limited to model parameter estimation and/or validity testing of the tools being developed.","Research Project Grants","Integrated Approaches, Theory & Data Analysis Tools","Informatics, Understanding Circuits","Systems Neuroscience"
"BRAIN Initiative:  Exploratory Team-Research BRAIN Circuit Programs - eTeamBCP (U01 Clinical Trials Optional)",RFA-NS-20-029,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-20-029.html,Closed,2021-06-16,"set to be a reissue of:
https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-18-029.html","Cooperative Agreements","Integrated Approaches, Circuit Diagrams","Understanding Circuits","Systems Neuroscience"
"BRAIN Initiative: Standards to Define Experiments Related to the BRAIN Initiative (R01 Clinical Trial Not Allowed)",RFA-MH-20-128,https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-20-128.html,Closed,2021-09-03,"This Funding Opportunity Announcement (FOA) solicits applications to develop standards that describe experimental protocols that are being conducted as part of The BRAIN Initiative®. It is expected that applications will solicit community input at all stages of the process. It is recommended that the first step of standard development will involve sharing data between different key groups in the experimental community in order to ensure that the developing standard will cover the way that all of those groups are collecting data. The developed standard is expected to be made widely available.","Research Project Grants","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools",Informatics,"Data Science & Informatics"
"BRAIN Initiative: Biology and Biophysics of Neural Stimulation and Recording Technologies (R01 Clinical Trials Optional)",RFA-NS-20-006,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-20-006.html,Closed,2022-10-04,"A central goal of the BRAIN Initiative is to develop new and improved technologies suitable for recording from as well as controlling specified cell types and circuits to modulate and understand function in the central nervous system. In order to accomplish these goals, further information is needed to understand the function of current technologies used for recording or stimulating the nervous system. This RFA accepts grant applications in two related but distinct areas. The first is to systematically characterize, model, and validate the membrane, cellular, circuit, and adaptive-biological responses of neuronal and non-neuronal cells to various types of stimulation technologies. The second is to understand the biological and bioinformatic content of signals recorded from neuronal and non-neuronal cells and circuits. Development of new technologies, therapies and disease models, are outside the scope of this FOA. Activities related to enabling the simultaneous use of multiple recording or stimulation technologies are allowed.","Research Project Grants","Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools","Investigative Human Neuroscience","Human Neuroscience, Neural Recording & Modulation"
"BRAIN Initiative:  Non-Invasive Neuromodulation - New Tools and Techniques for Spatiotemporal Precision (R01 Clinical Trial Optional)",RFA-MH-20-310,https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-20-310.html,Closed,2020-10-16,"This Funding Opportunity Announcement (FOA) solicits grant applications in two related but distinct areas. The first area is in the development and testing of novel tools and methods of neuromodulation that go beyond the existing forms of neural stimulation. The second distinct area that this FOA seeks to encourage is the optimization of existing stimulation methods.","Research Project Grants","Human Neuroscience, Interventional Tools, Monitor Neural Activity","Investigative Human Neuroscience, Therapeutic Human Neuroscience","Neuroimaging Technologies Across Scales"
"BRAIN Initiative: Development of Next Generation Human Brain Imaging Tools and Technologies (U01 Clinical Trial not allowed)",RFA-EB-19-002,https://grants.nih.gov/grants/guide/rfa-files/RFA-EB-19-002.html,Closed,2021-09-04,"This funding opportunity announcement (FOA), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, aims to support full development of entirely new or next generation noninvasive human brain imaging tools and methods that will lead to transformative advances in our understanding of the human brain. The FOA seeks innovative applications that are ready for full-scale development of breakthrough technologies with the intention of delivering working tools. This FOA represents the second stage of the tool/technology development effort that started with RFA-MH-14-217 and RFA-MH-15-200","Cooperative Agreements","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools",,"Human Neuroscience, Neuroimaging Technologies Across Scales"
"BRAIN Initiative: Proof of Concept Development of Early Stage Next Generation Human Brain Imaging (R01 Clinical Trial Not Allowed)",RFA-EB-19-001,RFA-EB-19-001,Closed,2019-09-04,"This funding opportunity announcement (FOA), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, aims to support early stage development of entirely new and novel noninvasive human brain imaging technologies and methods that will lead to transformative advances in our understanding of the human brain. The FOA solicits unusually bold and potentially transformative approaches and supports small-scale, proof-of-concept development based on exceptionally innovative, original and/or unconventional concepts.","Research Project Grants","Human Neuroscience, Interventional Tools, Monitor Neural Activity",,"Human Neuroscience, Neuroimaging Technologies Across Scales"
"Marmoset Colonies for Neuroscience Research (U24 Clinical Trials Not Allowed)",RFA-MH-20-145,RFA-MH-20-145,Closed,2019-09-06,"The common marmoset has recently emerged as a promising model system to understand the primate brain. In particular, marmoset behavior is similar in many ways to human behavior and the technology for germ line transmission of exogenous genetic information is now possible. However, existing colonies and commercial sources are currently unable to provide sufficient marmosets for neuroscience research. This Funding Opportunity Announcement (FOA) solicits applications to expand existing colonies of the common marmoset (Callithrix jacchus) for neuroscience research in the United States. Awardees under this FOA are expected to expand their current marmoset colonies to provide healthy, well-characterized animals that will be made available to the neuroscience research community. Awardees are also expected to participate in and provide health and genetic information to an NIH-Funded Marmoset Coordination Center to help the community understand the pedigree of individuals in the relatively small captive marmoset population and improve the genetic diversity of that population across multiple colonies.","Research Project Grants","Cell Type, Circuit Diagrams",,"Tools/Tech for Brain Cells/Circuits"
"Marmoset Coordination Center (U24 Clinical Trials Not Allowed)",RFA-MH-20-150,RFA-MH-20-150,Closed,2019-10-18,"This Funding Opportunity Announcement (FOA) solicits applications to create a Marmoset Coordination Center. The awardee will be responsible for two separate but related activities. The first activity will be to become the repository for genomic, pedigree, and event records (date of birth, medical, reproductive history) for captive marmosets. The awardee is expected to use that information to help make breeding recommendations to maximize the health and genetic diversity of the marmosets in primate colonies. Applicants are encouraged to adopt the model used by the Association of Zoos and Aquariums. The second major activity of the awardee will be to maintain a web site and an information support center to assist neuroscience researchers who are used to working with other animal models so that they may assess the utility of including marmosets in their scientific research program. In cases where the neuroscientists want to move forward, the Coordination Center will link the investigators to marmoset colonies that may be able to facilitate their science.","Cooperative Agreements, Research Project Grants","Cell Type, Circuit Diagrams",,"Tools/Tech for Brain Cells/Circuits"
"Brain Initiative: Research to Develop and Validate Advanced Human Cell-Based Assays To Model Brain Structure and Function (R01 Clinical Trial Not Allowed)",RFA-MH-20-140,RFA-MH-20-140,Closed,2019-11-02,"This Funding Opportunity Announcement (FOA) encourages research grant applications directed toward developing next-generation human cell-derived assays that replicate complex nervous system architectures and physiology with improved fidelity over current capabilities. This includes technologies that do not rely on the use of human fetal tissue, as described in NOT-19-042. Supported projects will be expected to enable future studies of complex nervous system development, function and aging in healthy and disease states.","Research Project Grants","Cell Type, Circuit Diagrams","Armamentarium, Understanding Circuits","Human Neuroscience, Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative: Secondary Analysis and Archiving of BRAIN Initiative Data (R01 Clinical Trial Not Allowed)",RFA-MH-20-120,https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-20-120.html,Closed,2021-02-27,"The BRAIN Initiative® and the neuroscience field as a whole is generating massive and diverse research data across different modalities, spatiotemporal scales and species in efforts to advance our understanding of the brain. The data types are being produced through development and application of innovative technologies in high-throughput -omics profiling, optical microscopy, electron microscopy, electrophysiological recording, macroscale neuroimaging, neuromodulation, and others. The BRAIN Initiative® has made significant investments in the development of an infrastructure to make data available to the research community in a useful way. This infrastructure includes data archives, data standards, and software for data integration, analysis and machine learning. This Funding Opportunity Announcement (FOA) encourages secondary analysis of the large amounts of existing data related to The BRAIN Initiative®. The data do not need to be held in one of the funded BRAIN Initiative data archives, but the data must be held in a data archive that is readily accessible to the research community. Support will be provided for innovative analysis of relevant existing datasets using conventional or novel analytic methods, data science techniques, and machine learning approaches. Support may also be requested to prepare and submit existing data into any of The BRAIN Initiative® data archives. Investigators should not underestimate the time and effort that may be necessary to curate or harmonize data. Analyzed data, models and analytical tools generated under this FOA are expected to be deposited into an appropriate data archive. Since The BRAIN Initiative® data archives are mostly making the data available to the research community through cloud-based storage, depositing the analyzed data, models and tools are expected to enhance opportunities to create a data sandbox where investigators can easily compare the results of their analysis with those from other research groups.","Research Project Grants","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools",Informatics,"Data Science & Informatics"
"BRAIN Initiative: Tools to Facilitate High-Throughput Microconnectivity Analysis (R01 Clinical Trial Not Allowed)",RFA-MH-20-135,https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-20-135.html,Closed,2020-10-01,"The purpose of this Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative is to encourage applications that will develop and validate tools and resources to facilitate the detailed analysis of brain microconnectivity. Novel and augmented techniques are sought that will ultimately be broadly accessible to the neuroscience community for the interrogation of microconnectivity in healthy and diseased brains of model organisms and humans. Development of technologies that will significantly drive down the cost of connectomics would enable routine mapping of the microconnectivity on the same individuals that have been analyzed physiologically, or to compare normal and pathological tissues in substantial numbers of multiple individuals to assess variability. Advancements in both electron microscopy (EM) and super resolution light microscopic approaches are sought. Applications that propose to develop approaches that break through existing technical barriers to substantially improve current capabilities are highly encouraged. Proof-of-principle demonstrations and/or reference datasets enabling future development are welcome, as are improved approaches for automated segmentation and analysis strategies of neuronal structures in EM images.no","Research Project Grants","Cell Type, Circuit Diagrams",Armamentarium,"Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed)",RFA-NS-19-006,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-19-006.html,Closed,2021-06-28,"This funding opportunity announcement (FOA) supports efforts to disseminate resources and to integrate them into neuroscience research practice.  Projects should be highly relevant to specific goals of the BRAIN Initiative, goals that are described in the planning document ""BRAIN 2025: A Scientific Vision."" They should engage in one or more of the following activities: distribution of tools and reagents; user training on the usage of new technologies or techniques; providing access to existing technology platforms and specialized facilities; minor improvements to increase the scale/efficiency of resource production and delivery; minor adaptations to meet the needs of a user community. Applications strictly focused on technology or software development, rather than dissemination of an existing resource, are not responsive to this FOA. Refinements to microscopes or tools necessary to customize them to the experimental needs of the end users is allowed. Projects should address compelling needs of neuroscience researchers working toward the goals of the BRAIN 2025 report that are otherwise unavailable or impractical in their current form.","Cooperative Agreements","Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory & Data Analysis Tools","Dissemination, Informatics",Dissemination
"BRAIN Initiative Cell Census Network (BICCN) Specialized Collaboratory on Human and Non-Human Primate Brain Cell Atlases (U01 Clinical Trial Not Allowed)",RFA-MH-19-149,https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-19-149.html,Closed,2020-01-25,"This Funding Opportunity Announcement (FOA) intends to support a group of Specialized Collaboratories that will adopt scalable technology platforms and streamlined workflows to accelerate progress towards establishing comprehensive molecular and anatomical reference cell atlases of human brain and/or non-human primate brains. A central goal of this FOA is to build a brain cell census resource that can be widely used throughout the research community.","Cooperative Agreements","Cell Type, Circuit Diagrams, Human Neuroscience","Cell Census Network (BICCN)","Human Neuroscience, Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative: Research on the Ethical Implications of Advancements in Neurotechnology and Brain Science (R01 Clinical Trial Optional)",RFA-MH-19-400,https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-19-400.html,Closed,2020-10-10,"This funding opportunity announcement (FOA), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, is one of several FOAs aimed at supporting transformative discoveries that will lead to breakthroughs in understanding human brain function. Guided by the long-term scientific plan, BRAIN 2025: A Scientific Vision, this FOA specifically seeks to support efforts addressing core ethical issues associated with research focused on the human brain and resulting from emerging technologies and advancements supported by The BRAIN Initiative®. The hope is that efforts supported under this FOA might be both complementary and integrative with the transformative, breakthrough neuroscience discoveries supported through The BRAIN Initiative®.","Research Project Grants","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools",Neuroethics,Neuroethics
"BRAIN Initiative Cell Census Network (BICCN) Scalable Technologies and Tools for Brain Cell Census (R01 Clinical Trial Not Allowed)",RFA-MH-19-148,https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-19-148.html,Closed,2020-01-25,"This Funding Opportunity Announcement (FOA) intends to accelerate the integration and use of scalable technologies and tools to enhance brain cell census research, including the development of technology platforms and/or resources that will enable a swift and comprehensive survey of brain cell types and circuits. Applications are expected to address limitations and gaps of existing technologies/tools as a benchmark against which the improvements or competitive advantages of the proposed ones will be measured. The improvements include throughput, sensitivity, selectivity, scalability, spatiotemporal resolution and reproducibility in cell census analyses. The projects funded under this FOA will align with the overarching goals of The BRAIN Initiative® Cell Census Network (BICCN) and are expected to enable the generation of a substantial amount of cell census data using the proposed technologies or via collaboration with the BICCN.","Research Project Grants","Cell Type, Circuit Diagrams","Cell Census Network (BICCN)","Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP (U19 Clinical Trial Required)",RFA-NS-19-002,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-19-002.html,Closed,2020-10-30,"This FOA will support integrated, interdisciplinary research teams from prior BRAIN technology and/or integrated approaches teams, and/or new projects from the research community that focus on examining circuit functions related to behavior, using advanced and innovative technologies. The goal will be to support programs with a team science approach that can realize meaningful outcomes within 5-plus years. Awards will be made for 5 years, with a possibility of one competing renewal. Applications should address overarching principles of circuit function in the context of specific neural systems underlying sensation, perception, emotion, motivation, cognition, decision-making, motor control, communication, or homeostasis. Applications should incorporate theory-/model-driven experimental design and should offer predictive models as deliverables. Applications should seek to understand circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating relevant dynamic patterns of neural activity and by measuring the resulting behaviors and/or perceptions. Applications are expected to employ approaches guided by specified theoretical constructs, and are encouraged to employ quantitative, mechanistic models where appropriate. Applications will be required to manage their data and analysis methods in a prototype framework that will be developed and used in the proposed U19 project and exchanged with other U19 awardees for further refinement and development. Model systems, including the possibility of multiple species ranging from invertebrates to humans, can be employed and should be appropriately justified. Budgets should be commensurate with multi-component teams of research expertise including neurobiologists, statisticians, physicists, mathematicians, engineers, computer scientists, and data scientists, as appropriate - that seek to cross boundaries of interdisciplinary collaboration.","Cooperative Agreements","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Theory & Data Analysis Tools","Investigative Human Neuroscience, Understanding Circuits","Human Neuroscience, Systems Neuroscience"
"BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP (U19 Clinical Trial Not Allowed)",RFA-NS-19-003,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-19-003.html,Closed,2021-10-30,"This FOA will support integrated, interdisciplinary research teams from prior BRAIN technology and/or integrated approaches teams, and/or new projects from the research community that focus on examining circuit functions related to behavior, using advanced and innovative technologies. The goal will be to support programs with a team science approach that can realize meaningful outcomes within 5-plus years.  Awards will be made for 5 years, with a possibility of one competing renewal.  Applications should will incorporate overarching principles of circuit function in the context of specific neural systems underlying sensation, perception, emotion, motivation, cognition, decision-making, motor control, communication, or homeostasis.  Applications should incorporate theory-/model-driven experimental design and should offer predictive models as deliverables. Applications should seek to understand circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating relevant dynamic patterns of neural activity and by measuring the resulting behaviors and/or perceptions.  Applications are expected to employ approaches guided by specified theoretical constructs, and are encouraged to employ quantitative, mechanistic models where appropriate. Applications will be required to manage their data and analysis methods in a prototype framework that will be developed and used in the proposed U19 project and exchanged with other BRAIN U19 awardees for further refinement and development. Model systems, including the possibility of multiple species ranging from invertebrates to humans, can be employed and should be appropriately justified. Programs should employ multi-component teams of research expertise  including neurobiologists, statisticians, physicists, mathematicians, engineers, computer scientists, and data scientists, as appropriate - that seek to cross boundaries of interdisciplinar","Cooperative Agreements","Cell Type, Integrated Approaches, Circuit Diagrams, Theory & Data Analysis Tools","Understanding Circuits","Systems Neuroscience"
"BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (U01 Clinical Trial Required)",RFA-NS-19-001,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-19-001.html,Closed,2021-10-30,"Invasive surgical procedures provide the unique ability to record and stimulate neurons within precisely localized brain structures in humans.  Human studies using invasive technology are often constrained by a limited number of patients and resources available to implement complex experimental protocols and are rarely aggregated in a manner that addresses research questions with appropriate statistical power.  Therefore, this RFA seeks applications to assemble diverse, integrated, multi-disciplinary teams that cross boundaries of interdisciplinary collaboration to overcome these fundamental barriers and to investigate high-impact questions in human neuroscience.  Projects should maximize opportunities to conduct innovative in vivo neuroscience research made available by direct access to brain recording and stimulating from invasive surgical procedures. Projects should employ approaches guided by specified theoretical constructs and quantitative, mechanistic models where appropriate.
Awardees will join a consortium work group, coordinated by the NIH, to identify consensus standards of practice, including neuroethical considerations, to collect and provide data for ancillary studies, and to aggregate and standardize data for dissemination among the wider scientific community.","Cooperative Agreements","Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","Understanding Circuits, Investigative Human Neuroscience","Systems Neuroscience, Human Neuroscience"
"Development of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in Human and Non-Human Primate Brain (UG3/UH3 Clinical Trial Optional)",RFA-MH-19-135,https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-19-135.html,Closed,2021-05-28,"The purpose of this Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative funding opportunity announcement is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis and manipulation of complex circuits in large brains. Critical advances in the treatment of brain disorders in human populations are hindered by our lack of ability to monitor and manipulate circuitry in safe, minimally-invasive ways. Clinical intervention with novel cell and circuit specific tools will require extensive focused research designed to remove barriers to delivery of gene therapies. In addition to identification and removal of barriers, the need to specifically target dysfunctional circuitry poses additional challenges. Neuroscience has experienced an impressive influx of exciting new research tools in the past decade, especially since the launch of The BRAIN Initiative®. However, the majority of these cutting-edge tools have been developed for use in model organisms, primarily rodents, fish and flies. These cutting-edge tools, such as viral delivery of genetic constructs, are increasingly adaptable to larger mammalian brains and more importantly are emerging as potential human therapeutic strategies for brain disorders. A pressing need to develop tools for use in large brains or those that are more directly relevant to the human brain is the focus of this initiative. The initiative will support initial proof of principle studies aimed at demonstrating the feasibility of this approach in humans and other mammalian species (non-human primate [NHP]/sheep/pigs).","Cooperative Agreements","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Monitor Neural Activity",,"Human Neuroscience, Tools/Tech for Brain Cells/Circuits"
"Development Optimization, and Validation of Novel Tools and Technologies for Neuroscience Research (SBIR) (R43/R44 - Clinical Trial Not Allowed)",PA-18-871,https://grants.nih.gov/grants/guide/pa-files/PA-18-871.html,Closed,2021-05-07,"The purpose of this funding opportunity announcement (FOA) is to support the development of novel tools and technologies through the Small Business Technology Transfer (STTR) program to advance the field of neuroscience research. This FOA specifically supports the development of novel neurotechnologies as well as the translation of technologies developed through The BRAIN initiative® or through other funding programs, towards commercialization. Funding can support the iterative refinement of these tools and technologies with the end-user community, with an end-goal of scaling manufacture towards reliable, broad, sustainable dissemination and incorporation into regular neuroscience practice","Research Project Grants, Small Business Grants","Circuit Diagrams, Interventional Tools, Monitor Neural Activity","Dissemination, Public-Private Partnerships",Dissemination
"Development Optimization, and Validation of Novel Tools and Technologies for Neuroscience Research (STTR) (R41/R42 - Clinical Trials Not Allowed)",PA-18-870,https://grants.nih.gov/grants/guide/pa-files/PA-18-870.html,Closed,2021-05-07,"The purpose of this funding opportunity announcement (FOA) is to support the development of novel tools and technologies through the Small Business Technology Transfer (STTR) program to advance the field of neuroscience research. This FOA specifically supports the development of novel neurotechnologies as well as the translation of technologies developed through The BRAIN initiative® or through other funding programs, towards commercialization. Funding can support the iterative refinement of these tools and technologies with the end-user community, with an end-goal of scaling manufacture towards reliable, broad, sustainable dissemination and incorporation into regular neuroscience practice.","Small Business Grants","Circuit Diagrams, Interventional Tools, Monitor Neural Activity","Dissemination, Public-Private Partnerships",Dissemination
"Integration and Analysis of BRAIN Initiative Data (R01 Clinical Trial Not Allowed)",RFA-MH-19-147,https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-19-147.html,Closed,2021-03-05,"This Funding Opportunity Announcement (FOA) solicits applications to develop informatics tools for analyzing, visualizing, and integrating data related to The BRAIN Initiative® or to enhance our understanding of the brain.","Research Project Grants","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools",Informatics,"Data Science & Informatics"
"Data Archives for The BRAIN Initiative® (R24 Clinical Trial Optional)",RFA-MH-19-145,RFA-MH-19-145,Closed,2019-09-07,"This Funding Opportunity Announcement (FOA) solicits applications to develop web-accessible data archives to capture, store, and curate data related to BRAIN Initiative activities. The data archives will work with the research community to incorporate tools that allow users to analyze and visualize the data, but the creation of such tools is not part of this FOA. The data archives will use appropriate standards to describe the data, but the creation of such standards is not part of this FOA. A goal of this program is to advance research by creating a community resource data archive with appropriate standards and summary information that is broadly available and accessible to the research community for furthering research.","Research Project Grants","Cell Type, Circuit Diagrams, Monitor Neural Activity, Theory & Data Analysis Tools",Informatics,"Data Science & Informatics"
"Standards to Define Experiments Related to the BRAIN Initiative (R01 Clinical Trial Not Allowed)",RFA-MH-19-146,RFA-MH-19-146,Closed,2019-09-07,"This Funding Opportunity Announcement (FOA) solicits applications to develop standards that describe experimental protocols that are being conducted as part of The BRAIN Initiative®. It is expected that applications will solicit community input at all stages of the process. It is recommended that the first step of standard development will involve sharing data between different key groups in the experimental community in order to ensure that the developing standard will cover the way that all of those groups are collecting data. The developed standard is expected to be made widely available.","Research Project Grants","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools",Informatics,"Data Science & Informatics"
"BRAIN Initiative: Exploratory Team-Research BRAIN Circuit Programs - eTeamBCP (U01 Clinical Trial Not Allowed)",RFA-NS-18-029,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-18-029.html,Closed,2019-06-11,"The purpose of this FOA is to promote the integration of experimental, analytic, and theoretical capabilities for large-scale analysis of neural systems and circuits. This FOA seeks applications for exploratory research studies that use new and emerging methods for large scale recording and manipulation of neural circuits across multiple brain regions. Applications should propose to elucidate the contributions of dynamic circuit activity to a specific behavioral or neural system. Applications should seek to understand circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating relevant dynamic patterns of neural activity and by measuring the resulting behaviors and/or perceptions.  Studies should incorporate rich information on cell-types, on circuit functionality and connectivity, and should be performed in conjunction with sophisticated analysis of complex, ethologically relevant behaviors. Applications should propose teams of investigators that seek to cross boundaries of interdisciplinary collaboration by bridging fields and linking theory and data analysis to experimental design. Exploratory studies supported by this FOA are intended to develop experimental capabilities and quantitative, theoretical frameworks in preparation for a future competition for larger-scale, multi-component, Team-Research BRAIN Circuit Programs (U19).","Cooperative Agreements","Integrated Approaches, Circuit Diagrams","Understanding Circuits","Systems Neuroscience"
"Development and Validation of Novel Tools to Analyze Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed)",RFA-MH-19-136,https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-19-136.html,Closed,2020-09-10,"The purpose of this Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function. The new tools and technologies should inform and/or exploit cell-type and/or circuit-level specificity. Plans for validating the utility of the tool/technology will be an essential feature of a successful application. The development of new genetic and non-genetic tools for delivering genes, proteins and chemicals to cells of interest or approaches that are expected to target specific cell types and/or circuits in the nervous system with greater precision and sensitivity than currently established methods are encouraged. Tools that can be used in a number of species/model organisms rather than those restricted to a single species are highly desired. Applications that provide approaches that break through existing technical barriers to substantially improve current capabilities are highly encouraged.","Research Project Grants","Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","Armamentarium, Understanding Circuits","Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative: Targeted BRAIN Circuits Projects- TargetedBCP (R01 Clinical Trial Not Allowed)",RFA-NS-18-030,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-18-030.html,Closed,2020-11-11,"This FOA solicits applications for research projects that use innovative, methodologically-integrated approaches to understand how circuit activity gives rise to mental experience and behavior. The goal is to support projects that can realize a meaningful outcome within 5 years. Applications should address circuit function in the context of specific neural systems such as sensation, perception, attention, reasoning, intention, decision-making, emotion, navigation, communication or homeostasis. Projects should link theory and data analysis to experimental design and should produce predictive models as deliverables. Projects should aim to improve the understanding of circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating dynamic patterns of neural activity.  Projects can use non-human and human species, and applications should explain how the selected species offers ideal conditions for revealing general principles about the circuit basis of a specific behavior.","Research Project Grants","Integrated Approaches, Circuit Diagrams","Understanding Circuits","Systems Neuroscience"
"BRAIN Initiative: Optimization of Transformative Technologies for Large Scale Recording and Modulation in the Nervous System (U01-Clinical Trials Not Allowed)",RFA-NS-18-019,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-18-019.html,Closed,2021-05-05,"Although invention and proof-of-concept testing of new technologies are a key component of the BRAIN Initiative, to achieve their potential these technologies must also be optimized through feedback from end-users in the context of the intended experimental use. This seeks applications for the optimization of existing and emerging technologies and approaches that have potential to address major challenges associated with recording and manipulating neural activity, at or near cellular resolution, at multiple spatial and temporal scales, in any region and throughout the entire depth of the brain. This FOA is intended for the iterative refinement of emergent technologies and approaches that have already demonstrated their transformative potential through initial proof-of-concept testing, and are appropriate for accelerated development of hardware and software while scaling manufacturing techniques towards sustainable, broad dissemination and user-friendly incorporation into regular neuroscience practice. Proposed technologies should be compatible with experiments in behaving animals, and should include advancements that enable or reduce major barriers to hypothesis-driven experiments. Technologies may engage diverse types of signaling beyond neuronal electrical activity for large-scale analysis, and may utilize any modality such as optical, electrical, magnetic, acoustic or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. Applications are expected to integrate appropriate domains of expertise, including where appropriate biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.","Cooperative Agreements","Interventional Tools, Monitor Neural Activity",,"Neural Recording & Modulation"
"BRAIN Initiative: New Technologies and Novel Approaches for Large-Scale Recording and Modulation in the Nervous System (R01 Clinical Trials Not Allowed)",RFA-NS-18-020,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-18-020.html,Closed,2021-05-05,"Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative. This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for largescale recording and manipulation of neural activity to enable transformative understanding of dynamic signaling in the nervous system. In particular, we seek exceptionally creative approaches to address major challenges associated with recording and manipulating neural activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain. It is expected that the proposed research may be high-risk, but if successful could profoundly change the course of neuroscience research. Proposed technologies should be compatible with experiments in behaving animals, and should include advancements that enable or reduce major barriers to hypothesis-driven experiments. Technologies may engage diverse types of signaling beyond neuronal electrical activity for large-scale analysis, and may utilize any modality such as optical, electrical, magnetic, acoustic or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. Where appropriate, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.","Research Project Grants","Interventional Tools, Monitor Neural Activity",,"Human Neuroscience, Neural Recording & Modulation"
"New Concepts and Early - Stage Research for Large - Scale Recording and Modulation in the Nervous System (R21 Clinical Trial Not Allowed)",RFA-EY-18-001,https://grants.nih.gov/grants/guide/rfa-files/RFA-EY-18-001.html,Closed,2020-10-30,"A central goal of The BRAIN Initiative® is to understand how electrical and chemical signals code information in neural circuits and give rise to sensations, thoughts, emotions and actions. While currently available technologies can provide some understanding, they may not be sufficient to accomplish this goal. For example, non-invasive technologies are low resolution and/or provide indirect measures such as blood flow, which are imprecise; invasive technologies can provide information at the level of single neurons producing the fundamental biophysical signals, but they can only be applied to tens or hundreds of neurons, out of a total number in the human brain estimated at 85 billion. Other BRAIN FOAs seek to develop novel technology (RFA-NS-17-003) or to optimize existing technology ready for in-vivo proof-of-concept testing and collection of preliminary data (RFA-NS-17-004) for recording or manipulating neural activity on a scale that is beyond what is currently possible. This FOA seeks applications for unique and innovative technologies that are in an even earlier stage of development than that sought in other FOAs, including new and untested ideas that are in the initial stages of conceptualization. In addition to experimental approaches, the support provided under this FOA might enable calculations, simulations, computational models, or other mathematical techniques for demonstrating that the signal sources and/or measurement technologies are theoretically capable of meeting the demands of large-scale recording or manipulation of circuit activity in humans or in animal models. The support might also be used for building and testing phantoms, prototypes, in-vitro or other bench-top models in order to validate underlying theoretical assumptions in preparation for future FOAs aimed at testing in animal models. Invasive or non-invasive approaches are sought that will ultimately enable or reduce the current barriers to large-scale recording or manipulation of neural activity, and that would ultimately be compatible with experiments in humans or behaving animals. Applications are encouraged from any qualified individuals, including physicists, engineers, theoreticians, and scientists, especially those not typically involved with neuroscience research.","Research Project Grants","Interventional Tools, Monitor Neural Activity",,"Human Neuroscience, Neural Recording & Modulation"
"BRAIN Initiative:  Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UG3/UH3 - Clinical Trial Required)",RFA-NS-18-021,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-18-021.html,Closed,2021-02-23,"The purpose of this Funding Opportunity Announcement (FOA) is to encourage investigators to pursue translational and clinical studies for recording and/or stimulating devices to treat nervous system disorders and better understand the human brain. The program will utilize a cooperative agreement mechanism to support the submission of an Investigational Device Exemption (IDE) for a Significant Risk (SR) study or obtain Institutional Review Board (IRB) approval for a Non-Significant Risk (NSR) study, and a subsequent small clinical trial (e.g., Early Feasibility Study). The small clinical trial should provide data to answer key questions about the function or final design of a device. This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval. The clinical trial is expected to provide information that cannot be practically obtained through additional nonclinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, and pursuit of regulatory approval for, and implementation of, a single small clinical trial. As part of the BRAIN Initiative, NIH has initiated a Public-Private Partnership Program (BRAIN PPP) that includes agreements (Memoranda of Understanding, MOU) with a number of device manufacturers willing to make such devices available, including devices and capabilities not yet market approved but appropriate for clinical research. In general, it is expected that the devices' existing safety and utility data will be sufficient to enable new IRB NSR or FDA IDE approval without need for significant additional non-clinical data. For more information on the BRAIN PPP, see http://braininitiative.nih.gov/BRAIN_PPP/.","Cooperative Agreements","Human Neuroscience, Interventional Tools, Monitor Neural Activity","Public-Private Partnerships, Therapeutic Human Neuroscience","Human Neuroscience, Neural Recording & Modulation"
"BRAIN Initiative: Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (U44 Clinical Trial Required)",RFA-NS-18-022,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-18-022.html,Closed,2021-02-23,"The purpose of this Funding Opportunity Announcement (FOA) is to encourage small business concerns (SBCs) to pursue translational non-clinical studies and clinical studies for recording and/or stimulating devices to treat nervous system disorders and thereby better understand the human brain. The program will utilize a cooperative agreement mechanism to support the non-clinical studies necessary for the submission of an Investigational Device Exemption (IDE) for a Significant Risk (SR) study or to obtain Institutional Review Board (IRB) approval for a Non-Significant Risk (NSR) study, and the subsequent small clinical trial (e.g., Early Feasibility Study). Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, and pursuit of regulatory approval for, and implementation of, a single small clinical trial. The small clinical trial should provide data to answer key questions about the function or final design of a device. This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval. The clinical trial is expected to provide information that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use.","Cooperative Agreements, Small Business Grants","Human Neuroscience, Interventional Tools, Monitor Neural Activity","Public-Private Partnerships, Therapeutic Human Neuroscience","Human Neuroscience, Neural Recording & Modulation"
"BRAIN Initiative:  Clinical Studies to Advance Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UH3 - Clinical Trial Required)",RFA-NS-18-023,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-18-023.html,Closed,2021-02-23,"The purpose of this Funding Opportunity Announcement (FOA) is to encourage investigators to pursue a small clinical trial to obtain critical information necessary to advance recording and/or stimulating devices to treat central nervous system disorders and better understand the human brain (e.g., Early Feasibility Study). Clinical studies supported may consist of acute or short-term procedures that are deemed Non-Significant Risk (NSR) by an Institutional Review Board (IRB), or Significant Risk (SR) studies that require an Investigational Device Exemption (IDE) from the FDA, such as chronic implants. The clinical trial should provide data to answer key questions about the function or final design of a device. This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval. The clinical trial is expected to provide information that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. Activities supported by this Funding Opportunity include a small clinical trial to answer key questions about the function or final design of a device. As part of the BRAIN Initiative, NIH has initiated a Public-Private Partnership Program (BRAIN PPP) that includes agreements (Memoranda of Understanding, MOU) with a number of device manufacturers willing to make such devices available, including devices and capabilities not yet market approved but appropriate for clinical research. In general it is expected that the devices' existing safety and utility data will be sufficient to enable new IRB NSR or FDA IDE approval without need for significant additional non-clinical data. For more information on the BRAIN PPP, see http://braininitiative.nih.gov/BRAIN_PPP/.","Cooperative Agreements","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools","Public-Private Partnerships, Therapeutic Human Neuroscience","Human Neuroscience, Neural Recording & Modulation"
"Development Optimization, and Validation of Novel Tools and Technologies for Neuroscience Research (STTR)(Clinical Trial Not Allowed)",PAR-18-515,PAR-18-515,Closed,2018-07-24,"The purpose of this funding opportunity announcement (FOA) is to support the development of novel tools and technologies through the Small Business Technology Transfer (STTR) program to advance the field of neuroscience research. This FOA specifically supports the development of novel neurotechnologies as well as the translation of technologies developed through The BRAIN Initiative® or through other funding programs, towards commercialization. Funding can support the iterative refinement of these tools and technologies with the end-user community, with an end-goal of scaling manufacture towards reliable, broad, sustainable dissemination and incorporation into regular neuroscience practice.","Small Business Grants","Circuit Diagrams, Interventional Tools, Monitor Neural Activity","Dissemination, Public-Private Partnerships",Dissemination
"Development Optimization, and Validation of Novel Tools and Technologies for Neuroscience Research (SBIR)(Clinical Trial Not Allowed)",PAR-18-501,PAR-18-501,Closed,2018-07-24,"The purpose of this funding opportunity announcement (FOA) is to support the development of novel tools and technologies through the Small Business Innovation Research (SBIR) program to advance the field of neuroscience research. This FOA specifically supports the development of novel neurotechnologies as well as the translation of technologies developed through The BRAIN Initiative® or through other funding programs, towards commercialization. Funding can support the iterative refinement of these tools and technologies with the end-user community, with an end-goal of scaling manufacture towards reliable, broad, sustainable dissemination and incorporation into regular neuroscience research.","Research Project Grants, Small Business Grants","Circuit Diagrams, Interventional Tools, Monitor Neural Activity","Dissemination, Public-Private Partnerships",Dissemination
"BRAIN Initiative: Targeted BRAIN Circuits Planning Projects  TargetedBCPP (R34 - Clinical Trials Not Allowed)",RFA-NS-18-014,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-18-014.html,Closed,2021-04-05,"This R34 FOA solicits applications that offer a limited scope of aims and an approach that will establish feasibility, validity, or other technically qualifying results that, if successful, would support, enable, and/or lay the groundwork for a potential, subsequent Targeted Brain Circuits Projects - TargetedBCP R01, as described in the companion FOA (RFA-NS-18-009). Applications should be exploratory research projects that use innovative, methodologically-integrated approaches to understand how circuit activity gives rise to mental experience and behavior.","Research Project Grants","Integrated Approaches, Circuit Diagrams","Understanding Circuits","Systems Neuroscience"
"BRAIN Initiative: Biology and Biophysics of Neural Stimulation (R01 - Clinical Trials Optional)",RFA-NS-18-018,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-18-018.html,Closed,2020-01-02,"A central goal of the BRAIN Initiative is to develop new and improved perturbation technologies suitable for controlling specified cell types and circuits to modulate function in the central nervous system. This FOA seeks applications to systematically characterize, model, and validate the membrane, cellular, circuit, and adaptive-biological responses of neuronal and non-neuronal cells to various types of stimulation. Development of new technologies and therapies, as well as of disease models are outside the scope of this FOA. However, activities related to combining multiple recording modalities are allowed. As part of this program, investigators will be required to participate in a consortium to develop standards and model systems for the evaluation of current and next generation neuromodulation technologies.","Research Project Grants","Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools","Investigative Human Neuroscience","Neural Recording & Modulation"
"BRAIN Initiative Fellows: Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship",RFA-MH-18-510,https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-18-510.html,Closed,2020-06-17,"The purpose of The BRAIN Initiative® Fellows (F32) program is to enhance the research training of promising postdoctorates, early in their postdoctoral training period, who have the potential to become productive investigators in research areas that will advance the goals of The BRAIN Initiative®. Applications are encouraged in any research area that is aligned with The BRAIN Initiative®, including neuroethics. Applicants are expected to propose research training in an area that clearly complements their predoctoral research. Formal training in analytical tools appropriate for the proposed research is expected to be an integral component of the research training plan. In order to maximize the training potential of the F32 award, this program encourages applications from individuals who have not yet completed their terminal doctoral degree and who expect to do so within 12 months of the application due date. On the application due date, candidates may not have completed more than 12 months of postdoctoral training. This Funding Opportunity Announcement (FOA) does not allow applicants to propose to lead an independent clinical trial, but does allow applicants to propose research experience in a clinical trial led by a sponsor or co-sponsor.","Research Training & Fellowships","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools",Training,Training
"Theories, Models and Methods for Analysis of Complex Data from the Brain (Clinical Trial Not Allowed)",RFA-EB-17-005,RFA-EB-17-005,Closed,2019-09-04,"--- Notice to change the Application Due Dates on BRAIN Initiative - NOT-EB-18-005 - https://grants.nih.gov/grants/guide/notice-files/NOT-EB-18-005.html --- This FOA solicits new theories, computational models, and statistical tools to derive understanding of brain function from complex neuroscience data. Proposed tools could include the creation of new theories, ideas, and conceptual frameworks to organize/unify data and infer general principles of brain function; new computational models to develop testable hypotheses and design/drive experiments; and new mathematical and statistical methods to support or refute a stated hypothesis about brain function, and/or assist in detecting dynamical features and patterns in complex brain data. It is expected that the tools developed under this FOA will be made widely available to the neuroscience research community for their use and modification. Investigative studies should be limited to validity testing of the tools being developed.","Research Project Grants","Integrated Approaches, Theory & Data Analysis Tools","Informatics, Understanding Circuits","Systems Neuroscience"
"BRAIN Initiative:  Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (U01)",RFA-NS-18-010,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-18-010.html,Closed,2018-01-20,"Invasive surgical procedures provide the unique ability to record and stimulate neurons within precisely localized brain structures in humans.  Human studies using invasive technology are often constrained by a limited number of patients and resources available to implement complex experimental protocols and are rarely aggregated in a manner that addresses research questions with appropriate statistical power.  Therefore, this FOA seeks applications to assemble integrated, multi-disciplinary teams to overcome these fundamental barriers.  Projects should investigate high-impact questions in human neuroscience.  The research should be offered as exploratory research and planning activities to establish feasibility, proof-of-principle and early-stage development that will later compete for continued funding under new or ongoing FOAs of the BRAIN Initiative or under NIH Institute appropriations. Projects should maximize opportunities to conduct innovative in vivo neuroscience research made available by direct access to brain recording and stimulating from invasive surgical procedures. In addition, projects that aim to implement novel methods of temporally-linked brain-behavior quantification in laboratory and real-world settings are encouraged.

Awardees will join a consortium work group, coordinated by the NIH, to identify consensus standards of practice as well as supplemental opportunities to collect and provide data for ancillary studies, and to aggregate and standardize data for dissemination among the wider scientific community.","Cooperative Agreements","Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","Understanding Circuits, Investigative Human Neuroscience","Systems Neuroscience, Human Neuroscience"
"BRAIN Initiative: Targeted BRAIN Circuits Projects- TargetedBCP (R01 - Clinical Trial Not Allowed)",RFA-NS-18-009,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-18-009.html,Closed,2018-03-16,"This FOA solicits applications for research projects that use innovative and methodologically-integrated approaches to understand how circuit activity gives rise to mental experience and behavior. The goal is to support projects that can realize a meaningful outcome within 5 years. Applications should address circuit function in the context of specific neural systems such as sensation, perception, attention, reasoning, intention, decision-making, emotion, navigation, communication, or homeostasis. Projects should link theory and data analysis to experimental design and should produce predictive models as deliverables. Projects should aim to improve the understanding of circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating dynamic patterns of neural activity.  Projects can use non-human animal species, and applications should explain how the selected species offers ideal conditions for revealing general principles about the circuit basis of a specific behavior.","Research Project Grants","Integrated Approaches, Circuit Diagrams","Understanding Circuits","Systems Neuroscience"
"Proof of Concept Development of Early Stage Next Generation Human Brain Imaging (Clinical Trials Not Allowed)",RFA-EB-17-003,RFA-EB-17-003,Closed,2018-12-12,"This funding opportunity announcement (FOA), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, aims to support early stage development of entirely new and novel noninvasive human brain imaging technologies and methods that will lead to transformative advances in our understanding of the human brain. The FOA solicits unusually bold and potentially transformative approaches and supports small-scale, proof-of-concept development based on exceptionally innovative, original and/or unconventional concepts.","Research Project Grants","Cell Type, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity",,"Human Neuroscience, Neuroimaging Technologies Across Scales"
"Development of Next Generation Human Brain Imaging Tools and Technologies (Clinical Trials Not Allowed)",RFA-EB-17-004,RFA-EB-17-004,Closed,2018-12-12,"This funding opportunity announcement (FOA), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, aims to support full development of entirely new or next generation noninvasive human brain imaging tools and methods that will lead to transformative advances in our understanding of the human brain. The FOA seeks innovative applications that are ready for full-scale development of breakthrough technologies with the intention of delivering working tools within the timeframe of The BRAIN Initiative® (“BRAIN 2025: A Scientific Vision,” http://braininitiative.nih.gov/). This FOA represents the second stage of the tool/technology development effort that started with RFA-MH-14-217 and RFA-MH-15-200.","Cooperative Agreements","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools",,"Human Neuroscience, Neuroimaging Technologies Across Scales"
"BRAIN Initiative: Exploratory Team-Research BRAIN Circuit Programs - eTeamBCP (U01)",RFA-NS-18-008,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-18-008.html,Closed,2017-12-16,"The purpose of this FOA is to promote the integration of experimental, analytic, and theoretical capabilities for large-scale analysis of neural systems and circuits. This FOA seeks applications for exploratory research studies that use new and emerging methods for large scale recording and manipulation of neural circuits across multiple brain regions. Applications should propose to elucidate the contributions of dynamic circuit activity to a specific behavioral or neural system. Applications should seek to understand circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating relevant dynamic patterns of neural activity and by measuring the resulting behaviors and/or perceptions.  Studies should incorporate rich information on cell-types, on circuit functionality and connectivity, and should be performed in conjunction with sophisticated analysis of complex, ethologically relevant behaviors. Applications should propose teams of investigators that seek to cross boundaries of interdisciplinary collaboration by bridging fields and linking theory and data analysis to experimental design. Exploratory studies supported by this FOA are intended to develop experimental capabilities and quantitative, theoretical frameworks in preparation for a future competition for larger-scale, multi-component, Team-Research Circuit Programs (U19) awards.","Cooperative Agreements, Program Project/Center Grants, Research Project Grants","Integrated Approaches, Circuit Diagrams","Understanding Circuits","Systems Neuroscience"
"Tools to target, identify and characterize non-neuronal cells in the brain - Clinical Trial Not Allowed",RFA-DA-18-018,RFA-DA-18-018,Closed,2018-10-05,"The purpose of this Funding Opportunity Announcement [FOA] submitted through the Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative is to stimulate the development and validation of novel tools and analytical methods to target, identify and characterize non-neuronal cells in the brain. This FOA complements previous and ongoing cell-census and tool development efforts initiated under BRAIN, RFA-MH-14-215 and RFA-MH-14-216, that have focused almost exclusively on neuronal cells. The cutting-edge tools and methods developed under this opportunity should focus specifically on providing improved points of entry into non-neuronal cell-types (glial and vascular) to enable their inventory and characterization within the CNS and help define how these cells interact among each other and with neuronal cells to impact functional circuitries. Plans for validating the utility of the tool/technology/method and demonstrating its advantage over currently available approaches will be an essential feature of a successful application. Tools that can be used in several species or model organisms rather than in a single species are especially desirable.","Research Project Grants","Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity",,"Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24)",RFA-NS-18-005,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-18-005.html,Closed,2018-02-10,"This funding opportunity announcement (FOA) supports efforts to disseminate resources and to integrate them into neuroscience research practice.  Projects should be highly relevant to specific goals of the BRAIN Initiative, goals that are described in the planning document ""BRAIN 2025: A Scientific Vision."" They should engage in one or more of the following activities: distribution of tools and reagents; user training on the usage of new technologies or techniques; providing access to existing technology platforms and specialized facilities; minor improvements to increase the scale/efficiency of resource production and delivery; minor adaptations to meet the needs of a user community. Applications strictly focused on technology or software development, rather than dissemination of an existing resource, are not responsive to this FOA. Refinements to microscopes or tools necessary to customize them to the experimental needs of the end users are allowed. Projects should address compelling needs of neuroscience researchers working toward the goals of the BRAIN 2025 report that are otherwise unavailable or impractical in their current form.","Cooperative Agreements, Program Project/Center Grants, Research Project Grants","Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory & Data Analysis Tools","Dissemination, Informatics",Dissemination
"Tools to Facilitate High-Throughput Microconnectivity Analysis",RFA-MH-18-505,RFA-MH-18-505,Closed,2018-11-14,"The purpose of this Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative is to encourage applications that will develop and validate tools and resources to facilitate the detailed analysis of brain microconnectivity. Novel and augmented techniques are sought that will ultimately be broadly accessible to the neuroscience community for the interrogation of microconnectivity in healthy and diseased brains of model organisms and humans. Development of technologies that will significantly drive down the cost of connectomics would enable routine mapping of the microconnectivity on the same individuals that have been analyzed physiologically, or to compare normal and pathological tissues in substantial numbers of multiple individuals to assess variability. Advancements in both electron microscopy (EM) and super resolution light microscopic approaches are sought. Applications that propose to develop approaches that break through existing technical barriers to substantially improve current capabilities are highly encouraged. Proof-of-principle demonstrations and/or reference datasets enabling future development are welcome, as are improved approaches for automated segmentation and analysis strategies of neuronal structures in EM images.","Research Project Grants","Cell Type, Circuit Diagrams","Understanding Circuits","Tools/Tech for Brain Cells/Circuits"
"Research on the Ethical Implications of Advancements in Neurotechnology and Brain Science",RFA-MH-18-500,RFA-MH-18-500,Closed,2017-12-08,"This funding opportunity announcement (FOA), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, is one of several FOAs aimed at supporting transformative discoveries that will lead to breakthroughs in understanding human brain function. Guided by the long-term scientific plan, “BRAIN 2025: A Scientific Vision,” this FOA specifically seeks to support efforts addressing core ethical issues associated with research focused on the human brain and resulting from emerging technologies and advancements supported by The BRAIN Initiative®. The hope is that efforts supported under this FOA might be both complementary and integrative with the transformative, breakthrough neuroscience discoveries supported through The BRAIN Initiative®.","Research Project Grants","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools",Neuroethics,Neuroethics
"New Concepts and Early - Stage Research for Large - Scale Recording and Modulation in the Nervous System",RFA-EY-17-002,RFA-EY-17-002,Closed,2017-10-27,"A central goal of The BRAIN Initiative® is to understand how electrical and chemical signals code information in neural circuits and give rise to sensations, thoughts, emotions and actions. While currently available technologies can provide some understanding, they may not be sufficient to accomplish this goal. For example, non-invasive technologies are low resolution and/or provide indirect measures such as blood flow, which are imprecise; invasive technologies can provide information at the level of single neurons producing the fundamental biophysical signals, but they can only be applied to tens or hundreds of neurons, out of a total number in the human brain estimated at 85 billion. Other BRAIN FOAs seek to develop novel technology (RFA-NS-17-003) or to optimize existing technology ready for in-vivo proof-of-concept testing and collection of preliminary data (RFA-NS-17-004) for recording or manipulating neural activity on a scale that is beyond what is currently possible. This FOA seeks applications for unique and innovative technologies that are in an even earlier stage of development than that sought in other FOAs, including new and untested ideas that are in the initial stages of conceptualization. In addition to experimental approaches, the support provided under this FOA might enable calculations, simulations, computational models, or other mathematical techniques for demonstrating that the signal sources and/or measurement technologies are theoretically capable of meeting the demands of large-scale recording or manipulation of circuit activity in humans or in animal models. The support might also be used for building and testing phantoms, prototypes, in-vitro or other bench-top models in order to validate underlying theoretical assumptions in preparation for future FOAs aimed at testing in animal models. Invasive or non-invasive approaches are sought that will ultimately enable or reduce the current barriers to large-scale recording or manipulation of neural activity, and that would ultimately be compatible with experiments in humans or behaving animals. Applications are encouraged from any qualified individuals, including physicists, engineers, theoreticians, and scientists, especially those not typically involved with neuroscience research.","Research Project Grants","Interventional Tools, Monitor Neural Activity",,"Human Neuroscience, Neural Recording & Modulation"
"BRAIN Initiative: Targeted BRAIN Circuits Projects - TargetedBCP (R01)",RFA-NS-17-014,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-17-014.html,Closed,2017-03-09,"This FOA solicits applications for research projects that use innovative, methodologically-integrated approaches to understand how circuit activity gives rise to mental experience and behavior. The goal is to support projects that can realize a meaningful outcome within 5 years. Applications should address circuit function in the context of specific neural systems such as sensation, perception, attention, reasoning, intention, decision-making, emotion, navigation, communication or homeostasis. Projects should link theory and data analysis to experimental design and should produce predictive models as deliverables. Projects should aim to improve the understanding of circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating dynamic patterns of neural activity. Projects can use non-human animal species, and applications should explain how the selected species offers ideal conditions for revealing general principles about the circuit basis of a specific behavior.","Research Project Grants","Circuit Diagrams, Integrated Approaches","Understanding Circuits","Systems Neuroscience"
"BRAIN Initiative: Exploratory Targeted BRAIN Circuits Projects - eTargetedBCP (R21)",RFA-NS-17-015,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-17-015.html,Closed,2017-03-09,"This FOA solicits applications for exploratory research projects that use innovative, methodologically-integrated approaches to understand how circuit activity gives rise to mental experience and behavior. Applications should offer a limited scope of aims and an approach that will establish feasibility, validity or other technically qualifying results that, if successful, would support a potential, subsequent Targeted Brain Circuits Projects - TargetedBCP R01, as described in the companion FOA (RFA-NS-17-014).","Research Project Grants","Integrated Approaches","Understanding Circuits","Human Neuroscience, Systems Neuroscience"
"BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP (U19)",RFA-NS-17-018,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-17-018.html,Closed,2017-10-18,"This FOA will support integrated, interdisciplinary research teams from prior BRAIN technology and/or integrated approaches teams, and/or new projects from the research community that focus on examining circuit functions related to behavior, using advanced and innovative technologies. The goal will be to support programs with a team science approach that can realize meaningful outcomes within 5-plus years. Awards will be made for 5 years, with a possibility of one competing renewal. Applications should address overarching principles of circuit function in the context of specific neural systems underlying sensation, perception, emotion, motivation, cognition, decision-making, motor control, communication, or homeostasis. Applications should incorporate theory-/model-driven experimental design and should offer predictive models as deliverables. Applications should seek to understand circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating relevant dynamic patterns of neural activity and by measuring the resulting behaviors and/or perceptions. Applications are expected to employ approaches guided by specified theoretical constructs, and are encouraged to employ quantitative, mechanistic models where appropriate. Applications will be required to manage their data and analysis methods in a prototype framework that will be developed and used in the proposed U19 project and exchanged with other U19 awardees for further refinement and development. Model systems, including the possibility of multiple species ranging from invertebrates to humans, can be employed and should be appropriately justified. Budgets should be commensurate with multi-component teams of research expertise including neurobiologists, statisticians, physicists, mathematicians, engineers, computer scientists, and data scientists, as appropriate - that seek to cross boundaries of interdisciplinary collaboration.","Cooperative Agreements","Circuit Diagrams, Integrated Approaches","Understanding Circuits","Systems Neuroscience"
"BRAIN Initiative:  Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (U01)",RFA-NS-17-019,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-17-019.html,Closed,2017-02-02,"Invasive surgical procedures provide the unique ability to record and stimulate neurons within precisely localized brain structures in humans.  Human studies using invasive technology are often constrained by a limited number of patients and resources available to implement complex experimental protocols and are rarely aggregated in a manner that addresses research questions with appropriate statistical power.  Therefore, this FOA seeks applications to assemble integrated, multi-disciplinary teams to overcome these fundamental barriers.  Projects should investigate high-impact questions in human neuroscience and disorders of the human nervous system.  The research should be offered as experimental projects, or exploratory research and planning activities, for building teams, generating data and empirical results that will later compete for continued funding under new or ongoing FOAs of the BRAIN Initiative or under NIH Institute appropriations.","Cooperative Agreements","Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","Understanding Circuits, Investigative Human Neuroscience","Systems Neuroscience, Human Neuroscience"
"Proof of Concept Development of Early Stage Next Generation Human Brain Imaging",RFA-EB-17-001,RFA-EB-17-001,Closed,2017-02-02,"This funding opportunity announcement (FOA), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, aims to support early stage development of entirely new and novel noninvasive human brain imaging technologies and methods that will lead to transformative advances in our understanding of the human brain. The FOA solicits unusually bold and potentially transformative approaches and supports small scale, proof of concept development based on exceptionally innovative, original and/or unconventional concepts.","Research Project Grants","Cell Type, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity",,"Human Neuroscience, Neuroimaging Technologies Across Scales"
"Research on the Ethical Implications of Advancements in Neurotechnology and Brain Science",RFA-MH-17-260,RFA-MH-17-260,Closed,2017-01-31,"This funding opportunity announcement (FOA), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, is one of several FOAs aimed at supporting transformative discoveries that will lead to breakthroughs in understanding human brain function. Guided by the long-term scientific plan, “BRAIN 2025: A Scientific Vision,” this FOA specifically seeks to support efforts addressing core ethical issues associated with research focused on the human brain and resulting from emerging technologies and advancements in research and development supported by The BRAIN Initiative®. The hope is that efforts supported under this FOA might be both complimentary and integrative with the transformative, breakthrough discoveries being supported through The BRAIN Initiative®.","Research Project Grants","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools",Neuroethics,Neuroethics
"Development of Next Generation Human Brain Imaging Tools and Technologies (Phase II)",RFA-EB-17-002,RFA-EB-17-002,Closed,2017-02-02,"This funding opportunity announcement (FOA), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, aims to support full development of entirely new or next generation noninvasive human brain imaging tools and methods that will lead to transformative advances in our understanding of the human brain. The FOA seeks innovative applications that are ready for full-scale development of breakthrough technologies with the intention of delivering working tools within the timeframe of the BRAIN Initiative (“BRAIN 2025: A Scientific Vision,” https://braininitiative.nih.gov/). This FOA represents the second stage of the tool/technology development effort that started with RFA-MH-14-217 and RFA-MH-15-200.","Cooperative Agreements","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools",,"Human Neuroscience, Neuroimaging Technologies Across Scales"
"BRAIN Initiative Cell Census Network (BICCN) - Specialized Center on Human and Non-Human Primate Brain Cell Atlases",RFA-MH-17-210,https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-17-210.html,Closed,2017-10-14,"This Funding Opportunity Announcement (FOA) intends to assemble a group of Specialized Collaboratories that will adopt scalable technology platforms and streamlined workflows to accelerate progress towards establishing reference cell atlases of human brain and/or non-human primate brains. A central goal of this and the three companion FOAs is to build a brain cell census resource that can be widely used throughout the research community. Watch an informational Webinar: https://youtu.be/Zd0JWzBJH5Q (Please copy and paste the url in your browser)","Cooperative Agreements","Cell Type, Circuit Diagrams, Human Neuroscience","Cell Census Network (BICCN)","Human Neuroscience, Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative Cell Census Network (BICCN) Brain Cell Data Center",RFA-MH-17-215,https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-17-215.html,Closed,2017-01-24,"This Funding Opportunity Announcement (FOA) intends to support a Brain Cell Data Center (BCDC) that will work with other BICCN Centers and interested researchers to establish a web-accessible information system to capture, store, analyze, curate, and display all data and metadata on brain cell types, and their connectivity. The BCDC is expected to: (1) lead the effort to establish spatial and semantic standards for managing heterogeneous brain cell census data types and information; (2) lead the effort to collect and register multimodal brain cell census data to common brain coordinate systems; (3) generate searchable 2D and 3D digital brain atlases for cell census data; and (4) generate a unified and comprehensive brain cell knowledge base that integrates all existing brain cell census data and information across diverse repositories. A central goal of this and the three companion FOAs is to build a brain cell census resource that can be widely used throughout the research community. Watch an informational Webinar: https://youtu.be/Zd0JWzBJH5Q (Please copy and paste the url in your browser)","Cooperative Agreements","Cell Type, Circuit Diagrams, Theory & Data Analysis Tools","Cell Census Network (BICCN)","Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative Cell Census Network (BICCN) Comprehensive Center on Mouse Brain Cell Atlas",RFA-MH-17-225,https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-17-225.html,Closed,2017-01-24,"This Funding Opportunity Announcement (FOA) intends to assemble a group of Comprehensive Centers that will adopt scalable technology platforms and streamlined workflows to generate a comprehensive 3D brain cell reference atlas encompassing molecular, anatomical, and physiological annotations of brain cell types in mouse, and incorporate additional genetic and other advanced cell-specific targeting approaches and tools to facilitate this goal. A central goal of this and the three companion FOAs is to build a brain cell census resource that can be widely used throughout the research community. Watch an informational Webinar: https://youtu.be/Zd0JWzBJH5Q (Please copy and paste the url in your browser)","Cooperative Agreements","Cell Type, Circuit Diagrams","Cell Census Network (BICCN)","Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative Cell Census Network (BICCN) - Specialized Center on Mouse Brain Cell Atlas",RFA-MH-17-230,https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-17-230.html,Closed,2017-10-14,"This Funding Opportunity Announcement (FOA) intends to support Specialized Collaboratory that will adopt scalable technology platforms and streamlined workflows to generate a comprehensive 3D brain cell reference atlas encompassing molecular, anatomical, and physiological annotations of brain cell types in mouse, and incorporate additional genetic and other advanced cell-specific targeting approaches and tools to facilitate this goal. A central goal of this and the three companion FOAs is to build a brain cell census resource that can be widely used throughout the research community. Watch an informational Webinar: https://youtu.be/Zd0JWzBJH5Q (Please copy and paste the url in your browser)","Cooperative Agreements","Cell Type, Circuit Diagrams","Cell Census Network (BICCN)","Tools/Tech for Brain Cells/Circuits"
"Research Career Enhancement Award for Investigators to Build Skills in a Cross-Disciplinary Area",RFA-DA-17-022,RFA-DA-17-022,Closed,2017-04-15,"This funding opportunity announcement (FOA) invites applications for mentored career enhancement (K18) awards in research areas that are highly relevant to the NIH BRAIN Initiative. This career enhancement program will support development of research capability for The BRAIN Initiative®, with specific emphasis on cross-training independent investigators in a substantively different area of neuroscience, neuroethics, or in a quantitative and physical discipline (e.g., physics, chemistry, engineering, computer science, mathematics); and vice versa, cross-training independent investigators trained in a quantitative or physical discipline proposing to gain in-depth training in a high-priority area of neuroscience. The research project conducted under this K18 should enhance the candidate’s ability to significantly contribute to or lead projects that investigate questions central to the goals of The BRAIN Initiative®. Eligible candidates are independent investigators at any faculty rank or level.","Career Development Awards","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools",Training,"Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative: New Technologies and Novel Approaches for Large-Scale Recording and Modulation in the Nervous System (U01)",RFA-NS-17-003,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-17-003.html,Closed,2017-10-19,"Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative. This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for largescale recording and manipulation of neural activity to enable transformative understanding of dynamic signaling in the nervous system. In particular, we seek exceptionally creative approaches to address major challenges associated with recording and manipulating neural activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain. It is expected that the proposed research may be high-risk, but if successful could profoundly change the course of neuroscience research.","Cooperative Agreements","Interventional Tools, Monitor Neural Activity",,"Human Neuroscience, Neural Recording & Modulation"
"BRAIN Initiative: Optimization of Transformative Technologies for Large Scale Recording and Modulation in the Nervous System (U01)",RFA-NS-17-004,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-17-004.html,Closed,2017-10-19,"Although invention and proof-of-concept testing of new technologies are a key component of the BRAIN Initiative, to achieve their potential these technologies must also be optimized through feedback from end-users in the context of the intended experimental use. This seeks applications for the optimization of existing and emerging technologies and approaches that have potential to address major challenges associated with recording and manipulating neural activity, at or near cellular resolution, at multiple spatial and temporal scales, in any region and throughout the entire depth of the brain. This FOA is intended for the iterative refinement of emergent technologies and approaches that have already demonstrated their transformative potential through initial proof-of-concept testing, and are appropriate for accelerated development of hardware and software while scaling manufacturing techniques towards sustainable, broad dissemination and user-friendly incorporation into regular neuroscience practice.","Cooperative Agreements","Interventional Tools, Monitor Neural Activity",,"Neural Recording & Modulation"
"BRAIN Initiative:  Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UG3/UH3)",RFA-NS-17-005,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-17-005.html,Closed,2017-10-19,"The purpose of this Funding Opportunity Announcement (FOA) is to encourage investigators to pursue translational and clinical studies for recording and/or stimulating devices to treat nervous system disorders and better understand the human brain. The program will utilize a cooperative agreement mechanism to support the submission of an Investigational Device Exemption (IDE) for a Significant Risk (SR) study or obtain Institutional Review Board (IRB) approval for a Non-Significant Risk (NSR) study, and a subsequent small clinical study (e.g., Early Feasibility Study). The small clinical study should provide data to answer key questions about the function or final design of a device. This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval. The clinical study is expected to provide information that cannot be practically obtained through additional nonclinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, and pursuit of regulatory approval for, and implementation of, a single small clinical study.","Cooperative Agreements","Human Neuroscience, Interventional Tools, Monitor Neural Activity","Public-Private Partnerships, Therapeutic Human Neuroscience","Human Neuroscience, Neural Recording & Modulation"
"BRAIN Initiative:  Clinical Studies to Advance Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UH3)",RFA-NS-17-006,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-17-006.html,Closed,2017-10-19,"The purpose of this Funding Opportunity Announcement (FOA) is to encourage investigators to pursue a small clinical study to obtain critical information necessary to advance recording and/or stimulating devices to treat central nervous system disorders and better understand the human brain (e.g., Early Feasibility Study). Clinical studies supported may consist of acute or short-term procedures that are deemed Non-Significant Risk (NSR) by an Institutional Review Board (IRB), or Significant Risk (SR) studies that require an Investigational Device Exemption (IDE) from the FDA, such as chronic implants. The clinical study should provide data to answer key questions about the function or final design of a device. This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval. The clinical study is expected to provide information that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. Activities supported by this Funding Opportunity include a small clinical study to answer key questions about the function or final design of a device.","Cooperative Agreements","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools","Public-Private Partnerships, Therapeutic Human Neuroscience","Human Neuroscience, Neural Recording & Modulation"
"BRAIN Initiative:  Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (U44)",RFA-NS-17-007,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-17-007.html,Closed,2017-10-19,"The purpose of this Funding Opportunity Announcement (FOA) is to encourage small business concerns (SBCs) to pursue translational non-clinical studies and clinical studies for recording and/or stimulating devices to treat nervous system disorders and thereby better understand the human brain. The program will utilize a cooperative agreement mechanism to support the non-clinical studies necessary for the submission of an Investigational Device Exemption (IDE) for a Significant Risk (SR) study or to obtain Institutional Review Board (IRB) approval for a Non-Significant Risk (NSR) study, and the subsequent small clinical study (e.g., Early Feasibility Study). Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, and pursuit of regulatory approval for, and implementation of, a single small clinical study. The small clinical study should provide data to answer key questions about the function or final design of a device. This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval. The clinical study is expected to provide information that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use.","Cooperative Agreements, Small Business Grants","Human Neuroscience, Interventional Tools, Monitor Neural Activity","Public-Private Partnerships, Therapeutic Human Neuroscience","Human Neuroscience, Neural Recording & Modulation"
"BRAIN Initiative: SBIR  Direct to Phase II Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (U44)",RFA-NS-17-008,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-17-008.html,Closed,2017-05-24,"The purpose of this Funding Opportunity Announcement (FOA) is to encourage small business concerns (SBCs) to pursue a small clinical study to obtain critical information necessary to advance recording and/or stimulating devices to treat central nervous system disorders and thereby better understand the human brain (e.g., Early Feasibility Study).  Clinical studies supported may consist of acute or short-term procedures that are deemed Non-Significant Risk (NSR) by an Institutional Review Board (IRB), or Significant Risk (SR) studies that require an Investigational Device Exemption (IDE) from the FDA, such as chronic implants.  The clinical study should provide data to answer key questions about the function or final design of a device.  This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval.  The clinical study is expected to provide information that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. Activities supported by this Funding Opportunity include a small clinical study to answer key questions about the function or final design of a device.","Cooperative Agreements, Small Business Grants","Human Neuroscience, Interventional Tools, Monitor Neural Activity","Public-Private Partnerships",
"Integration and Analysis of BRAIN Initiative Data",RFA-MH-17-257,RFA-MH-17-257,Closed,2017-10-27,"This Funding Opportunity Announcement (FOA) solicits applications to develop informatics tools for analyzing, visualizing, and integrating data related to The BRAIN Initiative® or to enhance our understanding of the brain.","Research Project Grants","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools",Informatics,"Data Science & Informatics"
"Technology Sharing and Propagation",RFA-MH-16-725,RFA-MH-16-725,Closed,2017-10-12,"The purpose of this Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative Funding Opportunity Announcement (FOA) is to encourage the transfer of new technologies and new data analysis techniques into a research laboratory. One of the key goals of The BRAIN Initiative® is to develop new technologies to improve our understanding of the brain. In order for those technologies to be useful, they need to be broadly disseminated beyond the laboratory or company where they originated. This FOA promotes this goal by providing funds to enable the incorporation of new technologies or data analysis techniques into research programs that further the aims of The BRAIN initiative®.","Research Project Grants","Cell Type, Circuit Diagrams, Monitor Neural Activity",Dissemination,Dissemination
"Data Archives for the BRAIN Initiative",RFA-MH-17-255,RFA-MH-17-255,Closed,2017-10-20,"This Funding Opportunity Announcement (FOA) solicits applications to develop web-accessible data archives to capture, store, and curate data related to BRAIN Initiative activities. The data archives will work with the research community to incorporate tools that allow users to analyze and visualize the data, but the creation of such tools is not part of this FOA. The data archives will use appropriate standards to describe the data, but the creation of such standards is not part of this FOA. A goal of this program is to advance research by creating a community resource data archive with appropriate standards and summary information that is broadly available and accessible to the research community for furthering research.","Research Project Grants","Cell Type, Circuit Diagrams, Monitor Neural Activity, Theory & Data Analysis Tools",Informatics,"Data Science & Informatics"
"Standards to Define Experiments Related to The BRAIN Initiative®",RFA-MH-17-256,RFA-MH-17-256,Closed,2017-10-11,"This Funding Opportunity Announcement (FOA) solicits applications to develop standards that describe experimental protocols that are being conducted as part of The BRAIN Initiative®. It is expected that applications will solicit community input at all stages of the process. It is recommended that the first step of standard development will involve sharing data between different key groups in the experimental community in order to ensure that the developing standard will cover the way that all of those groups are collecting data. The developed standard is expected to be made widely available.","Research Project Grants","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools",Informatics,"Data Science & Informatics"
"New Concepts and Early-Stage Research for Large-Scale Recording and Modulation in the Nervous System",RFA-EY-17-001,RFA-EY-17-001,Closed,2016-12-08,"A central goal of the BRAIN Initiative is to understand how electrical and chemical signals code information in neural circuits and give rise to sensations, thoughts, emotions and actions. While currently available technologies can provide some understanding, they may not be sufficient to accomplish this goal. For example, non-invasive technologies are low resolution and/or provide indirect measures such as blood flow, which are imprecise; invasive technologies can provide information at the level of single neurons producing the fundamental biophysical signals, but they can only be applied to tens or hundreds of neurons, out of a total number in the human brain estimated at 85 billion. Other BRAIN FOAs seek to develop novel technology (RFA-NS-16-006) or to optimize existing technology ready for in-vivo proof-of-concept testing and collection of preliminary data (RFA-NS-16-007) for recording or manipulating neural activity on a scale that is beyond what is currently possible. This FOA seeks applications for unique and innovative technologies that are in an even earlier stage of development than that sought in other FOAs, including new and untested ideas that are in the initial stages of conceptualization. In addition to experimental approaches, the support provided under this FOA might enable calculations, simulations, computational models, or other mathematical techniques for demonstrating that the signal sources and/or measurement technologies are theoretically capable of meeting the demands of large-scale recording or manipulation of circuit activity in humans or in animal models. The support might also be used for building and testing phantoms, prototypes, in-vitro or other bench-top models in order to validate underlying theoretical assumptions in preparation for future FOAs aimed at testing in animal models. It is expected that this research would be at a very early stage where preliminary data would not be available. Invasive or non-invasive approaches are sought that will ultimately enable or reduce the current barriers to large-scale recording or manipulation of neural activity, and that would ultimately be compatible with experiments in humans or behaving animals. Applications are encouraged from any qualified individuals, including physicists, engineers, theoreticians, and scientists, especially those not typically involved with neuroscience research.","Research Project Grants","Interventional Tools, Monitor Neural Activity",,"Human Neuroscience, Neural Recording & Modulation"
"New Concepts and Early-Stage Research for Large-Scale Recording and Modulation in the Nervous System",RFA-EY-16-001,RFA-EY-16-001,Closed,2016-12-08,"A central goal of the BRAIN Initiative is to understand how electrical and chemical signals code information in neural circuits and give rise to sensations, thoughts, emotions and actions. While currently available technologies can provide some understanding, they may not be sufficient to accomplish this goal. For example, non-invasive technologies are low resolution and/or provide indirect measures such as blood flow, which are imprecise; invasive technologies can provide information at the level of single neurons producing the fundamental biophysical signals, but they can only be applied to tens or hundreds of neurons, out of a total number in the human brain estimated at 85 billion. Other BRAIN FOAs seek to develop novel technology (RFA-NS-16-006) or to optimize existing technology ready for in-vivo proof-of-concept testing and collection of preliminary data (RFA-NS-16-007) for recording or manipulating neural activity on a scale that is beyond what is currently possible. This FOA seeks applications for unique and innovative technologies that are in an even earlier stage of development than that sought in other FOAs, including new and untested ideas that are in the initial stages of conceptualization.","Research Project Grants","Interventional Tools, Monitor Neural Activity",,"Human Neuroscience, Neural Recording & Modulation"
"BRAIN Initiative Fellows: Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship",RFA-MH-17-250,https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-17-250.html,Closed,2017-03-16,"The purpose of The BRAIN Initiative® Fellows (F32) program is to enhance the research training of promising postdoctorates, early in their postdoctoral training period, who have the potential to become productive investigators in research areas that will advance the goals of The BRAIN Initiative®. Applications are encouraged in any research area that is aligned with The BRAIN Initiative®, including neuroethics. Applicants are expected to propose research training in an area that complements their predoctoral research. Formal training in quantitative perspectives and analytical tools is expected to be an integral part of the proposed research training plan. In order to maximize the training potential of the F32 award, this program encourages applications from individuals who have not yet completed their terminal doctoral degree and who expect to do so within 12 months of the application due date. On the application due date, candidates may not have completed more than 6 months of postdoctoral training. Watch an informational Webinar: https://youtu.be/zVgsrsKb92s (Please copy and paste the url in your browser)","Research Training & Fellowships","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools",Training,Training
"Non-Invasive Neuromodulation - New Tools and Techniques for Spatiotemporal Precision",RFA-MH-17-240,RFA-MH-17-240,Closed,2017-10-14,"This Funding Opportunity Announcement (FOA) solicits grant applications in two related but distinct areas. The first area is in the development and testing of novel tools and methods of neuromodulation that go beyond the existing variations on magnetic or electrical stimulation, and that represent more than an incremental advance over existing approaches. The second distinct area that this FOA seeks to encourage is the optimization of existing electrical and magnetic stimulation methods.","Research Project Grants","Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity",,"Neuroimaging Technologies Across Scales"
"Non-Invasive Neuromodulation - Mechanisms and Dose/Response Relationships for Targeted CNS Effects",RFA-MH-17-245,RFA-MH-17-245,Closed,2017-10-14,"The focus of this Funding Opportunity Announcement (FOA) is to better understand how existing non-invasive neuromodulation devices affect brain circuity. This information should shed light on dose/response relationships that could be used for neuroscience applications and clinical interventions.","Research Project Grants","Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity",,"Neuroimaging Technologies Across Scales"
"Foundations of Non-Invasive Functional Human Brain Imaging and Recording - Bridging Scales and Modalities",RFA-MH-17-235,RFA-MH-17-235,Closed,2017-10-14,"This funding opportunity announcement (FOA), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, aims to support transformative discoveries that will lead to breakthroughs in understanding human brain function. Guided by the long-term scientific plan, “BRAIN 2025: A Scientific Vision,” this FOA specifically seeks to support efforts that will revolutionize our understanding of the biological activity underlying, and bioinformatic content of, data collected using contemporary non-invasive functional brain imaging techniques. The hope is that these transformative discoveries will lead to breakthroughs in understanding the dynamic activity of the human brain.","Research Project Grants","Human Neuroscience, Integrated Approaches, Monitor Neural Activity","Investigative Human Neuroscience","Human Neuroscience, Neuroimaging Technologies Across Scales"
"Development and Validation of Novel Tools to Analyze Cell-Specific and Circuit-Specific Processes in the Brain",RFA-MH-17-220,RFA-MH-17-220,Closed,2017-10-14,"The purpose of this Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function. The new tools and technologies should inform and/or exploit cell-type and/or circuit-level specificity. Plans for validating the utility of the tool/technology will be an essential feature of a successful application. The development of new genetic and non-genetic tools for delivering genes, proteins and chemicals to cells of interest or approaches that are expected to target specific cell types and/or circuits in the nervous system with greater precision and sensitivity than currently established methods are encouraged. Tools that can be used in a number of species/model organisms rather than those restricted to a single species are highly desired. Applications that provide approaches that break through existing technical barriers to substantially improve current capabilities are highly encouraged.","Research Project Grants","Cell Type, Circuit Diagrams, Monitor Neural Activity","Armamentarium, Understanding Circuits","Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative:  Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (U44)",RFA-NS-16-011,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-16-011.html,Closed,2016-04-27,"The purpose of this Funding Opportunity Announcement (FOA) is to encourage small business concerns (SBCs) to pursue translational non-clinical studies and clinical studies for recording and/or stimulating devices to treat nervous system disorders and thereby better understand the human brain.The program will utilize a cooperative agreement mechanism to support the non-clinical studies necessary for the submission of an Investigational Device Exemption (IDE) for a Significant Risk (SR) study or to obtain Institutional Review Board (IRB) approval for a Non-Significant Risk (NSR) study, and the subsequent small clinical study (e.g., Early Feasibility Study).Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, and pursuit of regulatory approval for, and implementation of, a single small clinical study. The small clinical study should provide data to answer key questions about the function or final design of a device.This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval.The clinical study is expected to provide information that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use.","Cooperative Agreements, Small Business Grants","Human Neuroscience, Interventional Tools, Monitor Neural Activity","Public-Private Partnerships, Therapeutic Human Neuroscience","Human Neuroscience, Neural Recording & Modulation"
"BRAIN Initiative:  SBIR Direct to Phase II Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (U44)",RFA-NS-16-018,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-16-018.html,Closed,2016-04-27,"The purpose of this Funding Opportunity Announcement (FOA) is to encourage small business concerns (SBCs) to pursue a small clinical study to obtain critical information necessary to advance recording and/or stimulating devices to treat central nervous system disorders and thereby better understand the human brain (e.g., Early Feasibility Study).Clinical studies supported may consist of acute or short-term procedures that are deemed Non-Significant Risk (NSR) by an Institutional Review Board (IRB), or Significant Risk (SR) studies that require an Investigational Device Exemption (IDE) from the FDA, such as chronic implants.The clinical study should provide data to answer key questions about the function or final design of a device.This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval.The clinical study is expected to provide information that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. Activities supported by this Funding Opportunity include a small clinical study to answer key questions about the function or final design of a device.","Cooperative Agreements, Small Business Grants","Human Neuroscience, Interventional Tools, Monitor Neural Activity","Public-Private Partnerships",
"Non-Invasive Neuromodulation – New Tools and Techniques for Spatiotemporal Precision",RFA-MH-16-810,RFA-MH-16-810,Closed,2016-02-19,"This Funding Opportunity Announcement (FOA) solicits grant applications in two related but distinct areas. The first area is in the development and testing of novel tools and methods of neuromodulation that go beyond the existing variations on magnetic or electrical stimulation, and that represent more than an incremental advance over existing electromagnetic approaches. The second distinct area that this FOA seeks to encourage is the optimization of existing electrical and magnetic stimulation methods.","Research Project Grants","Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity",,"Neuroimaging Technologies Across Scales"
"Non-Invasive Neuromodulation – Mechanisms and Dose/Response Relationships for Targeted CNS Effects",RFA-MH-16-815,RFA-MH-16-815,Closed,2016-02-19,"The focus of this Funding Opportunity Announcement (FOA) is to better understand how existing non-invasive neuromodulation devices affect brain circuity. This information should shed light on dose/response relationships that could be used for neuroscience applications and clinical interventions.","Research Project Grants","Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity",,"Neuroimaging Technologies Across Scales"
"BRAIN Initiative: New Technologies and Novel Approaches for Large-Scale Recording and Modulation in the Nervous System (U01)",RFA-NS-16-006,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-16-006.html,Closed,2016-02-25,"Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative.This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for large-scale recording and manipulation of neural activity to enable transformative understanding of dynamic signaling in the nervous system.In particular, we seek exceptionally creative approaches to address major challenges associated with recording and manipulating neural activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain.It is expected that the proposed research may be high-risk, but if successful could profoundly change the course of neuroscience research.","Cooperative Agreements","Interventional Tools, Monitor Neural Activity",,"Human Neuroscience, Neural Recording & Modulation"
"BRAIN Initiative: Optimization of Transformative Technologies for Large Scale Recording and Modulation in the Nervous System (U01)",RFA-NS-16-007,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-16-007.html,Closed,2016-02-25,"Although invention and proof-of-concept testing of new technologies is a key component of the BRAIN Initiative, to achieve their potential these technologies must also be optimized through feedback from end-users in the context of the intended experimental use. This seeks applications for the optimization of existing and emerging technologies and approaches that have potential to address major challenges associated with recording and manipulating neural activity, at or near cellular resolution, at multiple spatial and temporal scales, in any region and throughout the entire depth of the brain.This FOA is intended for the iterative refinement of emergent technologies and approaches that have already demonstrated their transformative potential through initial proof-of-concept testing, and are appropriate for accelerated development of hardware and software while scaling manufacturing techniques towards sustainable, broad dissemination and user-friendly incorporation into regular neuroscience practice.","Cooperative Agreements","Interventional Tools, Monitor Neural Activity",,"Neural Recording & Modulation"
"Development and Validation of Novel Tools to Analyze Cell-Specific and Circuit-Specific Processes in the Brain (R01)",RFA-MH-16-775,RFA-MH-16-775,Closed,2016-02-03,"The purpose of this Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function. The new tools and technologies should inform and/or exploit cell-type and/or circuit-level specificity. Plans for validating the utility of the tool/technology will be an essential feature of a successful application. The development of new genetic and non-genetic tools for delivering genes, proteins and chemicals to cells of interest or approaches that are expected to target specific cell types and/or circuits in the nervous system with greater precision and sensitivity than currently established methods are encouraged. Tools that can be used in a number of species/model organisms rather than those restricted to a single species are highly desired. Applications that provide approaches that break through existing technical barriers to substantially improve current capabilities are highly encouraged.","Research Project Grants","Cell Type, Circuit Diagrams, Monitor Neural Activity","Armamentarium, Understanding Circuits","Tools/Tech for Brain Cells/Circuits"
"BRAIN Initiative:  Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (U01)",RFA-NS-16-008,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-16-008.html,Closed,2016-01-14,"Invasive surgical procedures provide the unique ability to record and stimulate neurons within precisely localized brain structures in humans. Human studies using invasive technology are often constrained by a limited number of patients and resources available to implement complex experimental protocols and are rarely aggregated in a manner that addresses research questions with appropriate statistical power. Therefore, this FOA seeks applications to assemble integrated, multi-disciplinary teams to overcome these fundamental barriers. Projects should investigate high-impact questions in human neuroscience and disorders of the human nervous system. The research should be offered as experimental projects, or exploratory research and planning activities, for building teams, generating data and empirical results that will later compete for continued funding under new or ongoing FOAs of the BRAIN Initiative or under NIH Institute appropriations.","Cooperative Agreements","Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity","Investigative Human Neuroscience, Understanding Circuits","Human Neuroscience, Systems Neuroscience"
"Foundations of Non-Invasive Functional Human Brain Imaging and Recording - Bridging Scales and Modalities",RFA-MH-16-750,RFA-MH-16-750,Closed,2016-01-14,"This funding opportunity announcement (FOA), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, aims to support transformative discoveries that will lead to breakthroughs in understanding human brain function. Guided by the long-term scientific plan, “BRAIN 2025: A Scientific Vision,” this FOA specifically seeks to support efforts that will revolutionize our understanding of the biological activity underlying, and bioinformatic content of, data collected using contemporary non-invasive functional brain imaging techniques. The hope is that these transformative discoveries will lead to breakthroughs in understanding the dynamic activity of the human brain.","Research Project Grants","Human Neuroscience, Integrated Approaches, Monitor Neural Activity","Investigative Human Neuroscience","Human Neuroscience, Neuroimaging Technologies Across Scales"
"BRAIN Initiative:  Pre-Applications for Industry Partnerships to Provide Early Access to Devices for Stimulation and Recording in the Human Central Nervous System (X02)",PAR-15-345,http://grants.nih.gov/grants/guide/pa-files/PAR-15-345.html,Closed,2015-11-19,"This FOA is intended to facilitate partnerships between clinical investigators and manufacturers of latest-generation stimulating and/or recording devices that are FDA-designated as Class III (invasive, posing significant risk of harm), to conduct clinical research in the central nervous system.As part of The BRAIN InitiativeSM, NIH has initiated a Public-Private Partnership program (BRAIN PPP) to reduce barriers to negotiating such partnerships, and to ensure that new clinical studies leverage manufacturers existing data demonstrating safety and utility of these devices.Safety and utility data for invasive devices are costly to obtain, yet they are necessary for regulatory approval of human research, and therefore pose a substantial barrier to research progress.For this program, NIH has entered into agreements with a number of manufacturers to make available next generation devices that can stimulate and/or record from the central nervous system and have sufficient data to enable new Non-Significant Risk (NSR) or Investigational Device Exemption (IDE) without the need for significant additional testing.","Resource Grants","Human Neuroscience, Interventional Tools, Monitor Neural Activity","Dissemination, Public-Private Partnerships",Dissemination
"BRAIN Initiative:  Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UG3/UH3)",RFA-NS-16-009,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-16-009.html,Closed,2016-04-27,"The purpose of this Funding Opportunity Announcement (FOA) is to encourage investigators to pursue translational and clinical studies for recording and/or stimulating devices to treat nervous system disorders and better understand the human brain. The program will utilize a cooperative agreement mechanism to support the submission of an Investigational Device Exemption (IDE) for a Significant Risk (SR) study or obtain Institutional Review Board (IRB) approval for a Non-Significant Risk (NSR) study, and a subsequent small clinical study (e.g., Early Feasibility Study). The small clinical study should provide data to answer key questions about the function or final design of a device.This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval. The clinical study is expected to provide information that cannot be practically obtained through additional nonclinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, and pursuit of regulatory approval for, and implementation of, a single small clinical study.","Cooperative Agreements","Human Neuroscience, Interventional Tools, Monitor Neural Activity","Public-Private Partnerships, Therapeutic Human Neuroscience","Human Neuroscience, Neural Recording & Modulation"
"BRAIN Initiative:  Clinical Studies to Advance Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UH3)",RFA-NS-16-010,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-16-010.html,Closed,2016-04-27,"The purpose of this Funding Opportunity Announcement (FOA) is to encourage investigators to pursue a small clinical study to obtain critical information necessary to advance recording and/or stimulating devices to treat central nervous system disorders and better understand the human brain (e.g., Early Feasibility Study).Clinical studies supported may consist of acute or short-term procedures that are deemed Non-Significant Risk (NSR) by an Institutional Review Board (IRB), or Significant Risk (SR) studies that require an Investigational Device Exemption (IDE) from the FDA, such as chronic implants.The clinical study should provide data to answer key questions about the function or final design of a device.This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval.The clinical study is expected to provide information that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. Activities supported by this Funding Opportunity include a small clinical study to answer key questions about the function or final design of a device.","Cooperative Agreements","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools","Public-Private Partnerships, Therapeutic Human Neuroscience","Human Neuroscience, Neural Recording & Modulation"
"Short Courses in Computational Neuroscience",RFA-MH-16-700,RFA-MH-16-700,Closed,2015-11-07,"700 To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on Courses for Skills Development. This FOA will support short courses to facilitate the development of a sophisticated cadre of investigators with the requisite knowledge and skills in computational neuroscience perspectives and techniques for analyzing and interpreting complex, high-dimensional neuroscience data to advance The BRAIN Initiative®. For the purposes of this FOA, computational neuroscience encompasses theoretical neuroscience, computational and mathematical modeling of neural systems, and/or statistical perspectives and techniques. Each short course is expected to include both didactics and in-person/hands-on experiences. This FOA is intended for participants who are graduate students, medical students, postdoctoral scholars, medical residents, and/or early-career faculty.","Institutional Training Awards, Research Project Grants","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools",Training,Training
"Theories, Models and Methods for Analysis of Complex Data from the Brain",RFA-EB-15-006,RFA-EB-15-006,Closed,2015-10-22,"This FOA solicits new theories, computational models, and statistical methods to derive understanding of brain function from complex neuroscience data. Approaches could include the creation of new theories, ideas, and conceptual frameworks to organize/unify data and infer general principles of brain function; new computational models to develop testable hypotheses and design/drive experiments; and new mathematical and statistical methods to support or refute a stated hypothesis about brain function, and/or assist in detecting features in complex brain data.","Research Project Grants","Integrated Approaches, Theory & Data Analysis Tools","Informatics, Understanding Circuits","Systems Neuroscience"
"BRAIN Initiative: Optimization of Novel Tools and Technologies for Neuroscience Research (R44)",PAR-15-121,http://grants.nih.gov/grants/guide/pa-files/PAR-15-121.html,Closed,2017-01-06,"In this Funding Opportunity Announcement (FOA) we seek applications through the Small Business Innovation Research (SBIR) program for the optimization of existing and emerging technologies and approaches including 1) technologies and novel approaches for large scale recording and manipulation of neural activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain, 2) tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function. This FOA is intended for the iterative refinement of emergent technologies and approaches that have already demonstrated their transformative potential through initial proof-of-concept testing, and are appropriate for accelerated development with an end-goal of broad dissemination and incorporation into regular neuroscience practice.","Research Project Grants, Small Business Grants","Circuit Diagrams, Interventional Tools, Monitor Neural Activity",Dissemination,Dissemination
"BRAIN Initiative:  Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UH2/UH3)",RFA-NS-15-006,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-15-006.html,Closed,2015-04-15,"The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications to pursue translational and clinical studies for recording and/or stimulating devices to treat nervous system disorders and better understand the human brain. The program will utilize a cooperative agreement mechanism to support the submission of an Investigational Device Exemption (IDE) for a Significant Risk (SR) study or obtain Institutional Review Board (IRB) approval for a Non-Significant Risk (NSR) study, and a subsequent small clinical study (e.g., Early Feasibility Study). The small clinical study should provide data to answer key questions about the function or final design of a device.This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval. The clinical study is expected to provide information that cannot be practically obtained through additional nonclinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, and pursuit of regulatory approval for, and implementation of, a single small clinical study.","Small Business Grants","Human Neuroscience, Interventional Tools, Monitor Neural Activity","Public-Private Partnerships, Therapeutic Human Neuroscience","Human Neuroscience, Neural Recording & Modulation"
"BRAIN Initiative:  Clinical Studies to Advance Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UH3)",RFA-NS-15-008,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-15-008.html,Closed,2015-04-15,"The purpose of this FOA is to encourage applications to pursue a small clinical study to obtain critical information necessary to advance recording and/or stimulating devices to treat central nervous system disorders and better understand the human brain (e.g., Early Feasibility Study).Clinical studies supported may consist of acute or short-term procedures that are deemed Non-Significant Risk (NSR) by an Institutional Review Board, or Significant Risk (SR) studies that require an Investigational Device Exemption (IDE) from the FDA, such as chronic implants.The clinical study should provide data to answer key questions about the function or final design of a device.This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval. The clinical study is expected to provide information that cannot be practically obtained through additional nonclinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use.","Cooperative Agreements","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools","Public-Private Partnerships, Therapeutic Human Neuroscience","Human Neuroscience, Neural Recording & Modulation"
"Development, Optimization, and Validation of Novel Tools and Technologies for Neuroscience Research (SBIR)",PAR-15-091,PAR-15-091,Closed,2018-01-06,"The purpose of this funding opportunity announcement (FOA) is to support the development of novel tools and technologies through the Small Business Innovation Research (SBIR) program to advance the field of neuroscience research including 1) tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function, 2) proof-of-concept testing and development of new technologies and novel approaches for large scale recording and manipulation of neural activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain, and 3) iterative refinement of such tools and technologies with the end-user community with an end-goal of scaling manufacture towards reliable, broad, sustainable dissemination and incorporation into regular neuroscience practice. Application Receipt Date(s): Standard Dates Apply","Research Project Grants, Small Business Grants","Circuit Diagrams, Interventional Tools, Monitor Neural Activity","Dissemination, Public-Private Partnerships",Dissemination
"Development, Optimization, and Validation of Novel Tools and Technologies for Neuroscience Research (STTR)",PAR-15-090,PAR-15-090,Closed,2018-01-06,"The purpose of this funding opportunity announcement (FOA) is to support the development of novel tools and technologies through the through the Small Business Technology Transfer (STTR) program to advance the field of neuroscience research, including 1) tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function, 2) proof-of-concept testing and development of new technologies and novel approaches for large scale recording and manipulation of neural activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain, and 3) iterative refinement of such tools and technologies with the end-user community with an end-goal of scaling manufacture towards reliable, broad, sustainable dissemination and incorporation into regular neuroscience practice. Application Receipt Date(s): Standard Dates Apply","Small Business Grants","Circuit Diagrams, Interventional Tools, Monitor Neural Activity","Dissemination, Public-Private Partnerships",Dissemination
"Short Courses in Computational Neuroscience",RFA-MH-15-215,RFA-MH-15-215,Closed,2015-03-19,"This funding opportunity announcement (FOA) will support short courses to facilitate the development of a sophisticated cadre of investigators with the requisite knowledge and skills in computational neuroscience perspectives and techniques for analyzing and interpreting complex, high-dimensional neuroscience data to advance The BRAIN Initiative®. For the purposes of this FOA, computational neuroscience encompasses theoretical neuroscience, computational and mathematical modeling of neural systems, and/or statistical perspectives and techniques. Each short course is expected to include both didactics and in-person/hands-on experiences. This FOA is intended for participants who are graduate students, medical students, postdoctoral scholars, medical residents, and/or early-career faculty.","Institutional Training Awards, Research Project Grants","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools",Training,Training
"Short Courses in Research Tools and Methods",RFA-MH-15-220,RFA-MH-15-220,Closed,2015-03-19,"This funding opportunity announcement (FOA) will support creative educational activities with a primary focus on Courses for Skills Development that will build participants’ foundational knowledge and skills in the rigorous use of state-of-the art scientific tools and methods that contribute to, and are developed in response to, the major goals of the BRAIN Initiative®. Each short course is expected to include both didactics and in-person / hands-on experiences. This FOA is intended for participants who are graduate students, medical students, postdoctoral scholars, medical residents, and/or early-career faculty.","Institutional Training Awards, Research Project Grants","Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory & Data Analysis Tools",Training,Training
"New Concepts and Early- Stage Research for Large-Scale Recording and Modulation in the Nervous System",RFA-EY-15-001,RFA-EY-15-001,Closed,,"Previous BRAIN FOAs sought technologies ready for in-vivo proof-of-concept testing and collection of preliminary data. This FOA seeks applications for technology at an earlier stage of development. Support might enable simulations or other mathematical approaches, building and testing prototypes, or in vitro or other bench-top models, to validate theoretical assumptions regarding brain signal sources or proposed measurement technologies. Invasive or non-invasive approaches are sought that will enable or reduce barriers to large-scale recording or manipulation of neural activity, compatible with experiments in humans or behaving animals. Applications are encouraged from any qualified individuals, including physicists, engineers, theoreticians, and scientists, especially those not typically involved in neuroscience research.","Research Project Grants","Interventional Tools, Monitor Neural Activity",,"Human Neuroscience, Neural Recording & Modulation"
"Development and Validation of Novel Tools to Analyze Cell-Specific and Circuit-Specific Processes in the Brain",RFA-MH-15-225,RFA-MH-15-225,Closed,2015-03-19,"This announcement supports development and validation of novel tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function.","Cooperative Agreements","Cell Type, Circuit Diagrams, Monitor Neural Activity","Armamentarium, Understanding Circuits","Tools/Tech for Brain Cells/Circuits"
"Planning for Next Generation Human Brain Imaging",RFA-MH-15-200,RFA-MH-15-200,Closed,2015-03-19,"This funding opportunity announcement (FOA), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, aims to support planning activities and the initial stages of development of entirely new or next generation brain imaging technologies and methods that will lead to transformative advances in our understanding of the human brain.","Research Project Grants","Human Neuroscience, Interventional Tools, Monitor Neural Activity",,"Human Neuroscience, Neuroimaging Technologies Across Scales"
"BRAIN Initiative:  New Technologies and Novel Approaches for Large-Scale Recording and Modulation in the Nervous System (U01)",RFA-NS-15-003,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-15-003.html,Closed,2015-02-11,"Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative. This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for large scale recording and manipulation of neural activity, to enable transformative understanding of dynamic signaling in the nervous system. In particular we seek exceptionally creative approaches to address major challenges associated with recording and manipulating neural activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain. It is expected that the proposed research may be high risk, but if successful could profoundly change the course of neuroscience research. Proposed technologies should be compatible with experiments in behaving animals, and should include advancements that enable or reduce major barriers to hypothesis-driven experiments. Technologies may engage diverse types of signaling beyond neuronal electrical activity for large-scale analysis, and may utilize any modality such as optical, electrical, magnetic, acoustic or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. Where appropriate, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.","Cooperative Agreements","Interventional Tools, Monitor Neural Activity",,"Human Neuroscience, Neural Recording & Modulation"
"BRAIN Initiative: Optimization of Transformative Technologies for Large Scale Recording and Modulation in the Nervous System (U01)",RFA-NS-15-004,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-15-004.html,Closed,2015-02-11,"Although invention and proof-of-concept testing of new technologies are key components of the BRAIN Initiative, to achieve their potential these technologies must also be optimized through feedback from end-users in the context of the intended experimental use. In this FOA we seek applications for the optimization of existing and emerging technologies and approaches that have potential to address major challenges associated with recording and manipulating neural activity, at or near cellular resolution, at multiple spatial and temporal scales, in any region and throughout the entire depth of the brain. This FOA is intended for the iterative refinement of emergent technologies and approaches that have already demonstrated their transformative potential through initial proof-of-concept testing, and are appropriate for accelerated development of hardware and software while scaling manufacturing techniques towards sustainable, broad dissemination and user-friendly incorporation into regular neuroscience practice. Proposed technologies should be compatible with experiments in behaving animals, and should include advancements that enable or reduce major barriers to hypothesis-driven experiments. Technologies may engage diverse types of signaling beyond neuronal electrical activity for large-scale analysis, and may utilize any modality such as optical, electrical, magnetic, acoustic or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. Applications are expected to apply expertise that integrates appropriate domains of expertise, including where appropriate biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.","Cooperative Agreements","Interventional Tools, Monitor Neural Activity",,"Neural Recording & Modulation"
"BRAIN Initiative: Integrated Approaches to Understanding Circuit Function in the Nervous System (U01)",RFA-NS-15-005,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-15-005.html,Closed,2015-02-11,"The purpose of this FOA is to promote the integration of experimental, analytic, and theoretical capabilities for large-scale analysis of neural systems and circuits.  This FOA seeks applications for exploratory research studies that use new and emerging methods for large scale recording and manipulation of neural circuits across multiple brain regions.  Applications should propose to elucidate the contributions of dynamic circuit activity to a specific behavioral or neural system.  Studies should incorporate rich information on cell-types, on circuit functionality and connectivity, and should be performed in conjunction with sophisticated analysis of complex, ethologically relevant behaviors.  Applications should propose teams of investigators that seek to cross boundaries of interdisciplinary collaboration by bridging fields and linking theory and data analysis to experimental design.  Exploratory studies supported by this FOA are intended to develop experimental capabilities and quantitative, theoretical frameworks in preparation for a future competition for large scale awards.","Cooperative Agreements","Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Circuit Diagrams, Theory & Data Analysis Tools","Understanding Circuits","Systems Neuroscience, Human Neuroscience"
"BRAIN Initiative:  New Technologies and Novel Approaches for Large-Scale Recording and Modulation in the Nervous System (U01)",RFA-NS-14-007,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-14-007.html,Closed,2014-03-25,"Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative. This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for large scale recording and manipulation of neural activity, to enable transformative understanding of dynamic signaling in the nervous system. In particular we seek exceptionally creative approaches to address major challenges associated with recording and manipulating neural activity, with cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain. It is expected that the proposed research may be high risk, but if successful could profoundly change the course of neuroscience research.","Cooperative Agreements","Interventional Tools, Monitor Neural Activity",,"Human Neuroscience, Neural Recording & Modulation"
"BRAIN Initiative:  Optimization of Transformative Technologies for Large Scale Recording and Modulation in the Nervous System (U01)",RFA-NS-14-008,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-14-008.html,Closed,2014-03-25,"Although invention and proof-of-concept testing of new technologies is a key component of the BRAIN Initiative, to achieve their potential these technologies must also be optimized through feedback from end-users in the context of the intended experimental use. In this FOA we seek applications for the optimization of existing and emerging technologies and approaches that have potential to address major challenges associated with recording and manipulating neural activity, with cellular resolution, at multiple spatial and temporal scales, in any region and throughout the entire depth of the brain. This FOA is intended for the iterative refinement of emergent technologies and approaches that have already demonstrated their transformative potential through initial proof-of-concept testing, and are appropriate for accelerated engineering development with an end-goal of broad dissemination and incorporation into regular neuroscience practice.","Cooperative Agreements","Interventional Tools, Monitor Neural Activity",,"Neural Recording & Modulation"
"BRAIN Initiative:  Integrated Approaches to Understanding Circuit Function in the Nervous System (U01)",RFA-NS-14-009,http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-14-009.html,Closed,2014-03-25,"The purpose of this FOA is to provide resources for integrated development of experimental, analytic and theoretical capabilities for large-scale analysis of neural systems and circuits.  We seek applications for exploratory studies that use new and emerging methods for large scale recording and manipulation of neural circuits across multiple brain regions.  Applications should propose to elucidate the contributions of dynamic circuit activity to a specific behavioral or neural system.  Studies should incorporate rich information on cell-types, on circuit functionality and connectivity, and should be performed in conjunction with sophisticated analysis of ethologically relevant behaviors.  Applications should propose teams of investigators that seek to cross boundaries of interdisciplinary collaboration by bridging fields and linking theory and data analysis to experimental design.  Exploratory studies supported by this FOA are intended to develop experimental capabilities and theoretical frameworks in preparation for a future competition for large scale awards.","Cooperative Agreements","Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Circuit Diagrams, Theory & Data Analysis Tools","Understanding Circuits","Systems Neuroscience, Human Neuroscience"
"Development and Validation of Novel Tools to Analyze Cell-Specific and Circuit-Specific Processes in the Brain",RFA-MH-14-216,RFA-MH-14-216,Closed,2014-03-14,"aims to develop and validate novel tools that possess a high degree of cell-type and/or circuit-level specificity to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function. A particular emphasis is the development of new genetic and non-genetic tools for delivering genes, proteins and chemicals to cells of interest; new approaches are also expected to target specific cell types and or circuits in the nervous system with greater precision and sensitivity than currently established methods.","Cooperative Agreements","Cell Type, Circuit Diagrams, Monitor Neural Activity","Armamentarium, Understanding Circuits","Tools/Tech for Brain Cells/Circuits"
"Planning for Next Generation Human Brain Imaging",RFA-MH-14-217,RFA-MH-14-217,Closed,2014-03-28,"aims to create teams of imaging scientist together with other experts from a range of disciplines such as engineering, material sciences, nanotechnology and computer science, to plan for a new generation of non-invasive imaging techniques that would be used to understand human brain function. Incremental improvements to existing technologies will not be funded under this announcement.","Research Project Grants","Human Neuroscience, Interventional Tools, Monitor Neural Activity",,"Human Neuroscience, Neuroimaging Technologies Across Scales"
"Transformative Approaches for Cell-Type Classification in the Brain",RFA-MH-14-215,RFA-MH-14-215,Closed,2014-03-14,"aims to pilot classification strategies to generate a systematic inventory/cell census of cell types in the brain, integrating molecular identity of cell types with connectivity, morphology, and location. These pilot projects and methodologies should be designed to demonstrate their utility and scalability to ultimately complete a comprehensive cell census of the human brain.","Cooperative Agreements","Cell Type","Investigative Human Neuroscience","Tools/Tech for Brain Cells/Circuits"