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<title>Ultrasmall Gold Nnaorod Vesicle with Enhanced Tumor Accumulation and Fast Excertion From the Body for Cancer Therapy | NIH Research Festival</title>
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<article><div class="banner banner--gray banner--compact" style="--banner-background-image: url('/sites/default/files/media/image/2021-03/2015.jpg');--banner-background-focus: 50% 50%"><div class="banner__wrapper"><div class="banner__container"><h2 class="banner__heading">NIH Research Festival</h2><div class="banner__content"><p><strong><time datetime="2015-09-16">September 16</time> – <time datetime="2015-09-18">18, 2015</time></strong></p></div></div></div></div></article>
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<div class="section"><div data-drupal-messages-fallback class="hidden"></div></div><main role="main"><div id="main-content" tabindex="-1"></div><div class="section"><div class="content-sidebar"><div class="content-sidebar__main"><div class="content-sidebar__main-content"><div id="block-mainpagecontent-2"><article><h1>Ultrasmall Gold Nnaorod Vesicle with Enhanced Tumor Accumulation and Fast Excertion From the Body for Cancer Therapy</h1><div class="schedule"><div class="schedule__label"><div class="schedule__label-text"><time datetime="2015-09-17">Thursday, September 17, 2015</time>
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– Poster Session II
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</div></div><div class="schedule__content"><div class="schedule__item"><div class="schedule__time">12:00 – 1:30 p.m.</div><div class="schedule__description"><p><strong>FAES Terrace</strong></p></div><div class="schedule__description"><p><strong>NIBIB</strong></p></div><div class="schedule__description"><p><strong>CANCER-3</strong></p></div></div></div></div><h2>Authors</h2><ul><li>XY Chen</li></ul><h2>Abstract</h2><p>Gold nanorods (AuNRs) and their assemblies with optical absorption in the near-infrared (NIR) region have been widely used for bioimaging and photothermal cancer therapy. However, the commonly used AuNRs made by seed method usually have a width greater than 8 nm and length of about 40 nm, which have rapid reticuloendothelial system (RES) organ and tissue accumulation after intravenous administration and very slow clearance from the body. Herein, we report a new kind of small AuNRs (~8 × 2 nm) based on a seedless method, which are readily removed from the body by renal clearance. To increase the in vivo circulation time and tumor accumulation efficiency of the small AuNRs, a novel theranostic platform of biodegradable plasmonic AuNR vesicles with a size of ~60 nm was prepared by self-assembly of small amphiphilic AuNRs grafted with poly(ethylene glycol) (PEG) and poly(lactic-co-glycolic acid) (PLGA) (AuNR@PEG/PLGA) using an oil-in-water (O/W) emulsification method. The strong plasmonic coupling of AuNRs in the vesicular shell gives rise to high photothermal conversion efficiency and strong photoacoustic signal. Non-invasive positron emission tomography (PET) imaging demonstrated that the 64Cu-labeled vesicles can efficiently home to the tumor region after intravenous injection. Furthermore, complete tumor ablation was achieved using 808 nm NIR laser irradiation with low power density (0.4 W/cm2). The vesicles can be degraded into individual small AuNR@PEG, which are rapidly excreted from the body after exerting the photothermal effect in the tumor area.</p><p><strong>Scientific Focus Area</strong>: Cancer Biology</p><p class="updated"><small>This page was last updated on Friday, March 26, 2021</small></p></article>
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