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<strong>The site is secure.</strong>
|
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<br />
|
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The <strong>https://</strong> ensures that you are connecting to the
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official website and that any information you provide is encrypted
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and transmitted securely.
|
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|
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<a id="nws_header_accesskey_1" href="https://www.ncbi.nlm.nih.gov" class="usa-sr-only" accesskey="1" tabindex="-1">NCBI Homepage</a>
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<a id="nws_header_accesskey_2" href="/myncbi/" class="set-base-url usa-sr-only" accesskey="2" tabindex="-1">MyNCBI Homepage</a>
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<a id="nws_header_accesskey_3" href="#maincontent" class="usa-sr-only" accesskey="3" tabindex="-1">Main Content</a>
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<input type="hidden" name="csrfmiddlewaretoken" value="AlWvQ5tVQ5PnXSQYHCSopsCcvc3QCRHAR8GAtVWhqGCRRjWOkVvqTA8Q3gL2vsfU">
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<form action="/" method="get" autocomplete="off" class="usa-search usa-search-big search-form content-page-layout" id="search-form" role="search">
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<a class="pubmed-logo"
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aria-label="Pubmed Logo"
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href="/"
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data-ga-category="featured_link"
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<img src="https://cdn.ncbi.nlm.nih.gov/pubmed/277eb475-38df-4990-a0ee-0080b04e86fc/core/images/pubmed-logo-blue.svg" alt="pubmed logo" />
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<a href="#" class="search-input-trigger" data-alt-title="Hide search bar" title="Show search bar" aria-label="Show search bar">
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<div role="search" class="search-input">
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<div class="form-field ">
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<label class="usa-sr-only" for="id_term">
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Search:
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</label>
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<input
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type="search"
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name="term"
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data-skip-ie-scroll-to-top=""
|
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data-replace-term-with-exact=""
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data-exact-query=""
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placeholder=""
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class="term-input"
|
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required="required"
|
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id="id_term"/><a href="#" class="clear-btn" aria-label="Clear search input" title="Clear search input" role="button" data-pinger-ignore></a><button type="submit" class="search-btn" aria-label="Search" disabled data-pinger-ignore><span class="usa-search-submit-text">Search</span></button>
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</div>
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</div>
|
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<!-- Create alert and Create RSS are buttons that look like links -->
|
||
<!-- Better for them to look like buttons but no space -->
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<div class="search-links-wrapper content-page-layout">
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||
<div class="search-links">
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<a href="/advanced/"
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class="search-input-link adv-search-link"
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data-ga-category="featured_link"
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data-ga-action="adv_search">Advanced</a>
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<a href="/clipboard/"
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class="search-input-link clipboard-link hidden"
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data-ga-category="featured_link"
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data-ga-action="clipboard">
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Clipboard <span class="amount-in-clipboard"></span>
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</a>
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</div>
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<span class="search-input-link user-guide-link" role="navigation" aria-label="User guide">
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<a href="/help/"
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data-ga-category="featured_link"
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data-ga-action="user_guide">
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User Guide
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</a>
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</span>
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</div>
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</div>
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</form>
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<div id="article-page-header">
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<div id="article-top-actions-bar" class="article-top-actions-bar">
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<div class="inner-wrap">
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<div class="actions-container">
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<div class="return-to-search">
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</div>
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<div class="multiple-results-actions " role="region" aria-label="save, email, send to">
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<button id="save-results-panel-trigger"
|
||
type="button"
|
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class="save-results save-results-panel-trigger"
|
||
aria-expanded="false"
|
||
aria-controls="save-action-panel"
|
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data-ga-category="save_share"
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data-ga-action="save"
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||
data-ga-label="open">
|
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Save
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</button><button id="email-results-panel-trigger"
|
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type="button"
|
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class="email-results email-results-panel-trigger"
|
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aria-expanded="false"
|
||
aria-controls="email-action-panel"
|
||
data-ga-category="save_share"
|
||
data-ga-action="email"
|
||
data-ga-label="open">
|
||
Email
|
||
</button><div class="more-actions dropdown-block"><button id="more-actions-trigger"
|
||
type="button"
|
||
class="trigger more-actions-trigger"
|
||
ref="linksrc=show_moreactions_btn"
|
||
aria-label="Send to"
|
||
aria-controls="more-actions-dropdown">Send to</button><div id="more-actions-dropdown" class="dropdown dropdown-container" hidden><div class="content"><ul class="more-actions-links"><li><a class="clipboard-panel-trigger dropdown-block-link "
|
||
href="#"
|
||
role="button"
|
||
data-ga-category="save_share"
|
||
data-ga-action="clipboard"
|
||
data-ga-label="send">
|
||
Clipboard
|
||
</a></li><li><a role="button" class="dropdown-block-link bibliography-trigger-target" href="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F37778358%2F%23open-bibliography-panel">My Bibliography</a></li><li><a role="button" class="dropdown-block-link collections-trigger-target" href="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F37778358%2F%23open-collections-panel">Collections</a></li><li><a role="button" class="citation-manager-panel-trigger dropdown-block-link citation-manager-trigger-target" href="#">Citation manager</a></li></ul></div></div></div>
|
||
</div>
|
||
|
||
|
||
|
||
<div class="display-options" data-format-key="format"
|
||
data-default-format-value="abstract"
|
||
data-current-format-value="abstract" role="region">
|
||
<button
|
||
class="trigger usa-button"
|
||
title="Change format"
|
||
data-ga-category="display_options"
|
||
data-ga-action="display_options_dialog">
|
||
<span class="button-label">Display options</span>
|
||
</button>
|
||
|
||
<div class="dropdown" hidden>
|
||
<div class="title">
|
||
Display options
|
||
</div>
|
||
|
||
<div class="content">
|
||
|
||
<div class="format-container">
|
||
<span class="option-label">
|
||
Format
|
||
</span>
|
||
<select name="format" data-initial-value="abstract" aria-label="Display format" id="article-display-format">
|
||
<option value="abstract">Abstract</option>
|
||
|
||
<option value="pubmed">PubMed</option>
|
||
|
||
<option value="pmid">PMID</option>
|
||
|
||
</select>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="AlWvQ5tVQ5PnXSQYHCSopsCcvc3QCRHAR8GAtVWhqGCRRjWOkVvqTA8Q3gL2vsfU">
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="article-panels-container" class="article-panels-container">
|
||
<div id="save-action-panel" class="save-action-panel action-panel" aria-hidden="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Save citation to file
|
||
</h2>
|
||
<form id="save-action-panel-form"
|
||
class="action-panel-content action-form"
|
||
action="/results-export-ids/"
|
||
data-by-search-action="/results-export-search-data/"
|
||
data-by-ids-action="/results-export-ids/"
|
||
method="post"
|
||
data-by-search-method="post"
|
||
data-by-ids-method="post">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="AlWvQ5tVQ5PnXSQYHCSopsCcvc3QCRHAR8GAtVWhqGCRRjWOkVvqTA8Q3gL2vsfU">
|
||
|
||
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="save-action-format" class="action-panel-label">
|
||
Format:
|
||
</label>
|
||
<select id="save-action-format" name="results-format" class="action-panel-selector">
|
||
<option value="summary-text">Summary (text)</option>
|
||
<option value="pubmed-text">PubMed</option>
|
||
<option value="pmid">PMID</option>
|
||
<option value="abstract">Abstract (text)</option>
|
||
<option value="csv">CSV</option>
|
||
</select>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Saving..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="save"
|
||
data-ga-label="save">
|
||
Create file
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Save citations to file' panel"
|
||
ref="linksrc=close_save_panel"
|
||
aria-controls="save-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="save"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div id="email-action-panel"
|
||
class="email-action-panel action-panel"
|
||
aria-hidden="true"
|
||
data-recaptcha-script-url="https://www.recaptcha.net/recaptcha/enterprise.js?render=explicit&onload=onloadCaptchaCallback"
|
||
data-recaptcha-enabled="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Email citation
|
||
</h2>
|
||
<form id="email-action-panel-form"
|
||
class="action-panel-content action-form"
|
||
action="/send-email/"
|
||
data-by-search-action="/results-export-email-by-search-data/"
|
||
data-by-ids-action="/send-email/"
|
||
data-by-search-method="post"
|
||
data-by-ids-method="post"
|
||
method="post"
|
||
>
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="AlWvQ5tVQ5PnXSQYHCSopsCcvc3QCRHAR8GAtVWhqGCRRjWOkVvqTA8Q3gL2vsfU">
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<span class="action-panel-label">
|
||
Subject:
|
||
</span>
|
||
<span class="email-subject" id="email-subject" aria-label="Email subject">1 selected item: 37778358 - PubMed</span>
|
||
<input type="hidden" name="email-subject" value="1 selected item: 37778358"/>
|
||
<input type="hidden" name="email-subject-hash" value="bc88acddad8cd17d7fc1cdf6ba73a248b41ecb3aa717ea47ac30e7bf536776da"/>
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="email-to" class="action-panel-label required-field-asterisk">
|
||
To:
|
||
</label>
|
||
<input type="email" aria-label="Recipient Email Address" placeholder="email@example.com" id="email-to" class="email-to" pattern="^[a-zA-Z0-9_.+-]+@[a-zA-Z0-9-]+\.[a-zA-Z0-9-.]+$" maxlength="100" required>
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="email-from" class="action-panel-label">
|
||
From:
|
||
</label>
|
||
<input type="email" aria-label="Sender Email Address" placeholder="email@example.com" id="email-from" class="email-from" pattern="^[a-zA-Z0-9_.+-]+@[a-zA-Z0-9-]+\.[a-zA-Z0-9-.]+$" maxlength="256">
|
||
</div>
|
||
|
||
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="email-citation-format" class="action-panel-label">
|
||
Format:
|
||
</label>
|
||
<select id="email-citation-format" name="citation-format" class="action-panel-selector email-citation-format">
|
||
<option selected="selected" value="summary">Summary</option>
|
||
<option value="summary-text">Summary (text)</option>
|
||
<option value="abstract">Abstract</option>
|
||
<option value="abstract-text">Abstract (text)</option>
|
||
|
||
</select>
|
||
</div>
|
||
<div class="include-supplemental-container">
|
||
<input type="checkbox" aria-label="Include MeSH and other data" name="include-supplemental" id="email-include-supplemental" class="email-include-supplemental">
|
||
<label for="email-include-supplemental" class="email-include-supplemental-label">MeSH and other data</label>
|
||
</div>
|
||
|
||
|
||
|
||
<div class="form-field recaptcha ">
|
||
|
||
|
||
|
||
<div class="g-recaptcha" id="id-recaptcha" data-sitekey="6LfsWHMdAAAAAClKbtOpjQ2pMjgsGxvv7NdZW9uI"></div>
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
<div id="captcha-error-message" class="usa-input-error-message captcha-validation-message" role="alert"></div>
|
||
|
||
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Sending..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="email"
|
||
data-ga-label="send">
|
||
Send email
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Email citations' panel"
|
||
ref="linksrc=close_email_panel"
|
||
aria-controls="email-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="email"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
<input type="hidden" name="email-search-details" value="" />
|
||
<input type="hidden" name="email-search-details-hash" value="0e42663a6c3bd85498fcb88798998fed7bfdc45d457db35281e41afe13cc0524" />
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="collections-action-panel"
|
||
class="collections-action-panel action-panel in-progress-dots-panel"
|
||
aria-hidden="true"
|
||
data-collections-open-panel-enabled="false"
|
||
data-collections-open-panel-url-hash="#open-collections-panel">
|
||
<div class="inner-wrap">
|
||
<h3 class="action-panel-heading">
|
||
Add to Collections
|
||
</h3>
|
||
|
||
|
||
<form id="collections-action-panel-form"
|
||
class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
|
||
data-existing-collections-url="/list-existing-collections/"
|
||
data-add-to-existing-collection-url="/add-to-existing-collection/"
|
||
data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/"
|
||
data-get-article-ids-by-search-url="/get-article-ids-by-search/"
|
||
data-myncbi-max-collection-name-length="100"
|
||
data-add-to-collection-max-amount="1000"
|
||
data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="AlWvQ5tVQ5PnXSQYHCSopsCcvc3QCRHAR8GAtVWhqGCRRjWOkVvqTA8Q3gL2vsfU">
|
||
|
||
|
||
|
||
<div class="choice-group" role="radiogroup">
|
||
<ul class="radio-group-items">
|
||
<li>
|
||
<input type="radio"
|
||
id="collections-action-panel-new"
|
||
class="collections-new"
|
||
name="collections"
|
||
value="new"
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="collections_radio_new">
|
||
<label for="collections-action-panel-new">Create a new collection</label>
|
||
</li>
|
||
<li>
|
||
<input type="radio"
|
||
id="collections-action-panel-existing"
|
||
class="collections-existing"
|
||
name="collections"
|
||
value="existing"
|
||
checked="true"
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="collections_radio_existing">
|
||
<label for="collections-action-panel-existing">Add to an existing collection</label>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
|
||
<div class="controls-wrapper">
|
||
<div class="action-panel-control-wrap new-collections-controls">
|
||
<label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk">
|
||
Name your collection:
|
||
</label>
|
||
<input
|
||
type="text"
|
||
name="add-to-new-collection"
|
||
id="collections-action-panel-add-to-new"
|
||
class="collections-action-add-to-new"
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"
|
||
maxlength="100"
|
||
data-ga-category="save_share"
|
||
data-ga-action="create_collection"
|
||
data-ga-label="non_favorties_collection">
|
||
<div class="collections-new-name-too-long usa-input-error-message selection-validation-message">
|
||
Name must be less than 100 characters
|
||
</div>
|
||
</div>
|
||
<div class="action-panel-control-wrap existing-collections-controls">
|
||
<label for="collections-action-panel-add-to-existing" class="action-panel-label">
|
||
Choose a collection:
|
||
</label>
|
||
<select id="collections-action-panel-add-to-existing"
|
||
class="action-panel-selector collections-action-add-to-existing"
|
||
data-ga-category="save_share"
|
||
data-ga-action="select_collection"
|
||
data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'">
|
||
</select>
|
||
<div class="collections-retry-load-on-error usa-input-error-message selection-validation-message">
|
||
Unable to load your collection due to an error<br>
|
||
<a href="#">Please try again</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Adding..."
|
||
data-pinger-ignore
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="add">
|
||
Add
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Add to Collections' panel"
|
||
ref="linksrc=close_collections_panel"
|
||
aria-controls="collections-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="bibliography-action-panel"
|
||
class="bibliography-action-panel action-panel in-progress-dots-panel"
|
||
aria-hidden="true"
|
||
data-bibliography-open-panel-enabled="false"
|
||
data-bibliography-open-panel-url-hash="#open-bibliography-panel">
|
||
<div class="inner-wrap">
|
||
<h3 class="action-panel-heading">
|
||
Add to My Bibliography
|
||
</h3>
|
||
<form id="bibliography-action-panel-form"
|
||
class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
|
||
data-add-to-bibliography-max-amount="100"
|
||
data-add-to-bibliography-batch-size="10"
|
||
data-bibliography-delegates-url="/list-bibliography-delegates/"
|
||
data-add-to-bibliography-url="/add-to-bibliography/"
|
||
data-get-article-ids-by-search-url="/get-article-ids-by-search/"
|
||
data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="AlWvQ5tVQ5PnXSQYHCSopsCcvc3QCRHAR8GAtVWhqGCRRjWOkVvqTA8Q3gL2vsfU">
|
||
|
||
|
||
|
||
<div class="action-panel-control-wrap bibliographies-controls">
|
||
<div class="choice-group">
|
||
<ul class="bibliographies-action-add radio-group-items">
|
||
<li>
|
||
<input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/>
|
||
<label for="my-bibliography">My Bibliography</label>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message">
|
||
Unable to load your delegates due to an error<br>
|
||
<a href="#">Please try again</a>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Adding..."
|
||
data-pinger-ignore>
|
||
Add
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Add to bibliography' panel"
|
||
ref="linksrc=close_bibliography_panel"
|
||
aria-controls="bibliography-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="mybib"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true"
|
||
data-saved-search-open-panel-enabled="false"
|
||
data-saved-search-open-panel-url-hash="#open-saved-search-panel">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Your saved search
|
||
</h2>
|
||
|
||
<form id="saved-search-action-panel-form"
|
||
class="saved-search-action-panel-form action-panel-content action-form"
|
||
data-create-saved-search-url="/create-saved-search/"
|
||
data-try-search-terms-url="/try-search-term/"
|
||
data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="AlWvQ5tVQ5PnXSQYHCSopsCcvc3QCRHAR8GAtVWhqGCRRjWOkVvqTA8Q3gL2vsfU">
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk">
|
||
Name of saved search:
|
||
</label>
|
||
<input maxlength="200"
|
||
type="text"
|
||
name="saved-search-name"
|
||
id="saved-search-name"
|
||
class="saved-search-name"
|
||
value=""
|
||
required
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/">
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-term" class="action-panel-label required-field-asterisk">
|
||
Search terms:
|
||
</label>
|
||
<textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea>
|
||
</div>
|
||
<div class="test-search-term-wrap">
|
||
<a href="#" class="try-search-term">Test search terms</a>
|
||
</div>
|
||
<div class="choice-group action-panel-extra-margin-top">
|
||
<span class="action-panel-label" id="fieldset-label">
|
||
Would you like email updates of new search results?
|
||
</span>
|
||
<fieldset id="saved-search-alert" aria-describedby="fieldset-label">
|
||
<legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend>
|
||
<ul class="radio-group-items">
|
||
<li>
|
||
<input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked>
|
||
<label for="saved-search-alert-yes" class="action-panel-label">Yes</label>
|
||
</li>
|
||
<li>
|
||
<input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no">
|
||
<label for="saved-search-alert-no" class="action-panel-label">No</label>
|
||
</li>
|
||
</ul>
|
||
</fieldset>
|
||
</div>
|
||
|
||
<div class="alert-schedule-wrap">
|
||
<div class="action-panel-control-wrap">
|
||
<label class="action-panel-label">
|
||
Email:
|
||
</label>
|
||
<span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span>
|
||
</div>
|
||
<div class="action-panel-control-wrap action-panel-extra-margin-top">
|
||
<label for="saved-search-frequency" class="action-panel-label">
|
||
Frequency:
|
||
</label>
|
||
<select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency">
|
||
<option value="monthly">Monthly</option>
|
||
<option value="weekly">Weekly</option>
|
||
<option value="daily">Daily</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap saved-search-monthly-additional">
|
||
<label for="saved-search-monthly-on-day" class="action-panel-label">
|
||
Which day?
|
||
</label>
|
||
<select id="saved-search-monthly-on-day" class="no-border-panel-selector">
|
||
<option value="Sunday">The first Sunday</option>
|
||
<option value="Monday">The first Monday</option>
|
||
<option value="Tuesday">The first Tuesday</option>
|
||
<option value="Wednesday">The first Wednesday</option>
|
||
<option value="Thursday">The first Thursday</option>
|
||
<option value="Friday">The first Friday</option>
|
||
<option value="Saturday">The first Saturday</option>
|
||
<option value="day">The first day</option>
|
||
<option value="weekday">The first weekday</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap saved-search-weekly-additional">
|
||
<label for="saved-search-weekly-on-day" class="action-panel-label">
|
||
Which day?
|
||
</label>
|
||
<select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day">
|
||
<option value="Sunday">Sunday</option>
|
||
<option value="Monday">Monday</option>
|
||
<option value="Tuesday">Tuesday</option>
|
||
<option value="Wednesday">Wednesday</option>
|
||
<option value="Thursday">Thursday</option>
|
||
<option value="Friday">Friday</option>
|
||
<option value="Saturday">Saturday</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-report" class="action-panel-label">
|
||
Report format:
|
||
</label>
|
||
<select id="saved-search-report" class="no-border-panel-selector saved-search-report">
|
||
<option value="DocSum">Summary</option>
|
||
<option value="DocSumText">Summary (text)</option>
|
||
<option value="Abstract">Abstract</option>
|
||
<option value="AbstractText">Abstract (text)</option>
|
||
<option value="MEDLINE">PubMed</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-amount" class="action-panel-label">
|
||
Send at most:
|
||
</label>
|
||
<select id="saved-search-amount" class="no-border-panel-selector saved-search-amount">
|
||
<option value="1">1 item</option>
|
||
<option value="5" selected>5 items</option>
|
||
<option value="10">10 items</option>
|
||
<option value="20">20 items</option>
|
||
<option value="50">50 items</option>
|
||
<option value="100">100 items</option>
|
||
<option value="200">200 items</option>
|
||
</select>
|
||
</div>
|
||
<div>
|
||
<input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result">
|
||
<label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox">
|
||
Send even when there aren't any new results
|
||
</label>
|
||
</div>
|
||
<div class="action-panel-control-wrap option-text-in-email-wrap">
|
||
<label for="saved-search-email-text" class="action-panel-label">
|
||
Optional text in email:
|
||
</label>
|
||
<textarea name="saved-search-email-text"
|
||
id="saved-search-email-text"
|
||
class="saved-search-email-text"></textarea>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Saving..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="save">
|
||
Save
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Your saved search' panel"
|
||
ref="linksrc=close_saved_search_panel"
|
||
aria-controls="saved-search-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Create a file for external citation management software
|
||
</h2>
|
||
<form id="citation-manager-action-panel-form"
|
||
class="action-panel-content action-form"
|
||
action="/results-export-ids/"
|
||
data-by-search-action="/results-export-search-data/"
|
||
data-by-ids-action="/results-export-ids/"
|
||
method="post"
|
||
data-by-search-method="post"
|
||
data-by-ids-method="post">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="AlWvQ5tVQ5PnXSQYHCSopsCcvc3QCRHAR8GAtVWhqGCRRjWOkVvqTA8Q3gL2vsfU">
|
||
|
||
|
||
|
||
<input name="results-format" type="hidden" value="pubmed"/>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Sending..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="citation_manager"
|
||
data-ga-label="save">
|
||
Create file
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Send citations to citation manager' panel"
|
||
ref="linksrc=close_citation_manager_panel"
|
||
aria-controls="citation-manager-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="citation_manager"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Your RSS Feed
|
||
</h2>
|
||
|
||
<form id="rss-action-panel-form"
|
||
class="rss-action-panel-form action-panel-content action-form"
|
||
data-create-rss-feed-url="/create-rss-feed-url/"
|
||
data-search-form-term-value="">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="AlWvQ5tVQ5PnXSQYHCSopsCcvc3QCRHAR8GAtVWhqGCRRjWOkVvqTA8Q3gL2vsfU">
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="rss-name" class="action-panel-label required-field-asterisk">
|
||
Name of RSS Feed:
|
||
</label>
|
||
<input maxlength="200"
|
||
placeholder="Name"
|
||
type="text"
|
||
name="rss-name"
|
||
id="rss-name"
|
||
class="rss-name"
|
||
value=''
|
||
required
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/">
|
||
</div>
|
||
|
||
<div class="rss-limit-wrap">
|
||
<div class="action-panel-control-wrap action-panel-extra-margin-top">
|
||
<label for="rss-limit" class="action-panel-label">
|
||
Number of items displayed:
|
||
</label>
|
||
<select id="rss-limit" class="no-border-panel-selector rss-limit">
|
||
<option value="5">5</option>
|
||
<option value="10">10</option>
|
||
<option value="15" selected="selected">15</option>
|
||
<option value="20">20</option>
|
||
<option value="50">50</option>
|
||
<option value="100">100</option>
|
||
</select>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Creating..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="save">
|
||
Create RSS
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Your RSS' panel"
|
||
ref="linksrc=close_rss_panel"
|
||
aria-controls="rss-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap rss-link-copy-wrap">
|
||
<label for="rss-link" class="usa-sr-only">RSS Link</label>
|
||
<input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link">
|
||
<button
|
||
type="button"
|
||
disabled
|
||
class="rss-link-copy-button disabled"
|
||
data-ga-category="save_share"
|
||
data-ga-action="rss"
|
||
data-ga-label="copy">
|
||
Copy
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="article-page" id="article-page" data-article-pmid="37778358">
|
||
<aside class="page-sidebar">
|
||
<div class="inner-wrap">
|
||
|
||
<div class="full-text-links">
|
||
<div class="full-view">
|
||
<h3 class="title">
|
||
Full text links
|
||
</h3>
|
||
<div class="full-text-links-list">
|
||
<a class="link-item
|
||
|
||
dialog-focus"
|
||
href="https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(23)01460-5"
|
||
target="_blank"
|
||
rel="noopener"
|
||
|
||
ref="linksrc=fulltextorjournal_fulltext&is_pmc=False&PrId=3048&itool=Abstract-def&log$=linkouticon&uid=37778358&db=pubmed&nlmid=2985213R"
|
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Efficacy and safety of the neonatal Fc receptor inhibitor efgartigimod in adults with primary immune thrombocytopenia (ADVANCE IV): a multicentre, randomised, placebo-controlled, phase 3 trial
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<span class="authors-list-item "><a class="full-name"
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href="/?term=Broome+CM&cauthor_id=37778358"
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data-ga-label="Catherine M Broome">Catherine M Broome</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Lombardi Cancer Center, Division of Hematology, Georgetown University, Washington, DC, USA. Electronic address: catherine.m.broome@gunet.georgetown.edu." href="#full-view-affiliation-1" ref="linksrc=author_aff">
|
||
1
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=McDonald+V&cauthor_id=37778358"
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data-ga-label="Vickie McDonald">Vickie McDonald</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Clinical Haematology, Barts Health NHS Trust, London, UK." href="#full-view-affiliation-2" ref="linksrc=author_aff">
|
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2
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Miyakawa+Y&cauthor_id=37778358"
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data-ga-label="Yoshitaka Miyakawa">Yoshitaka Miyakawa</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Hematology, Saitama Medical University Hospital, Saitama, Japan." href="#full-view-affiliation-3" ref="linksrc=author_aff">
|
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3
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Carpenedo+M&cauthor_id=37778358"
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data-ga-label="Monica Carpenedo">Monica Carpenedo</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Hematology and Transplant Unit, UOC Hematology and Transplant Unit Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy." href="#full-view-affiliation-4" ref="linksrc=author_aff">
|
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4
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Kuter+DJ&cauthor_id=37778358"
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data-ga-label="David J Kuter">David J Kuter</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Hematology Division, Massachusetts General Hospital, Boston, MA, USA." href="#full-view-affiliation-5" ref="linksrc=author_aff">
|
||
5
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Al-Samkari+H&cauthor_id=37778358"
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data-ga-label="Hanny Al-Samkari">Hanny Al-Samkari</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Hematology Division, Massachusetts General Hospital, Boston, MA, USA." href="#full-view-affiliation-5" ref="linksrc=author_aff">
|
||
5
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Bussel+JB&cauthor_id=37778358"
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data-ga-label="James B Bussel">James B Bussel</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Division of Hematology and Medical Oncology and Division of Pediatric Hematology and Oncology, Weill Cornell Medical College, New York, NY, USA." href="#full-view-affiliation-6" ref="linksrc=author_aff">
|
||
6
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Godar+M&cauthor_id=37778358"
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data-ga-label="Marie Godar">Marie Godar</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="argenx, Ghent, Belgium." href="#full-view-affiliation-7" ref="linksrc=author_aff">
|
||
7
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Ayguasanosa+J&cauthor_id=37778358"
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data-ga-label="Jaume Ayguasanosa">Jaume Ayguasanosa</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="argenx, Ghent, Belgium." href="#full-view-affiliation-7" ref="linksrc=author_aff">
|
||
7
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=De+Beuf+K&cauthor_id=37778358"
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data-ga-label="Kristof De Beuf">Kristof De Beuf</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="argenx, Ghent, Belgium." href="#full-view-affiliation-7" ref="linksrc=author_aff">
|
||
7
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Rodeghiero+F&cauthor_id=37778358"
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data-ga-label="Francesco Rodeghiero">Francesco Rodeghiero</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Haematology Project Foundation, Department of Haematology, S Bortolo Hospital, Vicenza, Italy." href="#full-view-affiliation-8" ref="linksrc=author_aff">
|
||
8
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Michel+M&cauthor_id=37778358"
|
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|
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data-ga-label="Marc Michel">Marc Michel</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Internal Medicine, National Reference Center for Immune Cytopenias, Henri Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris-Est Créteil, Créteil, France." href="#full-view-affiliation-9" ref="linksrc=author_aff">
|
||
9
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Newland+A&cauthor_id=37778358"
|
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data-ga-label="Adrian Newland">Adrian Newland</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Centre for Haematology, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, UK." href="#full-view-affiliation-10" ref="linksrc=author_aff">
|
||
10
|
||
</a></sup><span class="semicolon">; </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=ADVANCE+Investigator+Study+Group%5BCorporate+Author%5D"
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data-ga-label="ADVANCE Investigator Study Group">ADVANCE Investigator Study Group</a></span>
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|
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|
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|
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|
||
|
||
</div>
|
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|
||
|
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|
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<div class="short-article-details">
|
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|
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Collaborators,
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|
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Affiliations
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|
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|
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<div class="collaborations">
|
||
<h3 class="title">
|
||
|
||
Collaborators
|
||
|
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</h3>
|
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<ul class="group-list">
|
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|
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<li>
|
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|
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<strong class="title">ADVANCE Investigator Study Group</strong>:
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<div class="authors-list">
|
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<span class="authors-list-item "><a class="full-name"
|
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href="/?term=Fillitz+M"
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data-ga-label="Michael Fillitz">Michael Fillitz</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Knoebl+P"
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data-ga-label="Paul Knoebl">Paul Knoebl</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Meers+S"
|
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data-ga-label="Stef Meers">Stef Meers</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Amine+IM"
|
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data-ga-label="Ismail Mohamad Amine">Ismail Mohamad Amine</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Gumulec+J"
|
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data-ga-label="Jaromir Gumulec">Jaromir Gumulec</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Hlusi+A"
|
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data-ga-label="Antonin Hlusi">Antonin Hlusi</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Mayer+J"
|
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data-ga-label="Jiri Mayer">Jiri Mayer</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Philippe Quittet">Philippe Quittet</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Viallard+JF"
|
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data-ga-label="Jean-Francois Viallard">Jean-Francois Viallard</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Betaneli+M"
|
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data-ga-label="Magdana Betaneli">Magdana Betaneli</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Datikashvili-David+I"
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data-ga-label="Irine Datikashvili-David">Irine Datikashvili-David</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Genadi Iosava">Genadi Iosava</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Levan Makhaldiani">Levan Makhaldiani</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Laszlo Rejto">Laszlo Rejto</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Sharashenidze+N"
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data-ga-label="Nino Sharashenidze">Nino Sharashenidze</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Stefanie Groepper">Stefanie Groepper</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Alexander Röth">Alexander Röth</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Hamed+A"
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data-ga-label="Aryan Hamed">Aryan Hamed</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Illes+A"
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data-ga-label="Arpad Illes">Arpad Illes</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Carpenedo+M"
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data-ga-label="Monica Carpenedo">Monica Carpenedo</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Artoni+A"
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data-ga-label="Andrea Artoni">Andrea Artoni</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Bocchia+M"
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data-ga-label="Monica Bocchia">Monica Bocchia</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Gamberi+B"
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data-ga-label="Barbara Gamberi">Barbara Gamberi</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Alessandra Borchiellini">Alessandra Borchiellini</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Oliva+EN"
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data-ga-label="Esther Natalie Oliva">Esther Natalie Oliva</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Andrea Patriarca">Andrea Patriarca</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Simona Tomassetti">Simona Tomassetti</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Yoshitaka Miyakawa">Yoshitaka Miyakawa</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Kiyoshi Ando">Kiyoshi Ando</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Hiroshi Handa">Hiroshi Handa</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Kaichi Nishiwaki">Kaichi Nishiwaki</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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<h3 class="title">
|
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Affiliations
|
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|
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|
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<li data-affiliation-id="full-view-affiliation-1"
|
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|
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><sup class="key">1</sup> Lombardi Cancer Center, Division of Hematology, Georgetown University, Washington, DC, USA. Electronic address: catherine.m.broome@gunet.georgetown.edu.</li>
|
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|
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<li data-affiliation-id="full-view-affiliation-2"
|
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|
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><sup class="key">2</sup> Department of Clinical Haematology, Barts Health NHS Trust, London, UK.</li>
|
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|
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<li data-affiliation-id="full-view-affiliation-3"
|
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><sup class="key">3</sup> Department of Hematology, Saitama Medical University Hospital, Saitama, Japan.</li>
|
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|
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<li data-affiliation-id="full-view-affiliation-4"
|
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><sup class="key">4</sup> Hematology and Transplant Unit, UOC Hematology and Transplant Unit Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.</li>
|
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|
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<li data-affiliation-id="full-view-affiliation-5"
|
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><sup class="key">5</sup> Hematology Division, Massachusetts General Hospital, Boston, MA, USA.</li>
|
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|
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<li data-affiliation-id="full-view-affiliation-6"
|
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|
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><sup class="key">6</sup> Division of Hematology and Medical Oncology and Division of Pediatric Hematology and Oncology, Weill Cornell Medical College, New York, NY, USA.</li>
|
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|
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<li data-affiliation-id="full-view-affiliation-7"
|
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|
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><sup class="key">7</sup> argenx, Ghent, Belgium.</li>
|
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|
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<li data-affiliation-id="full-view-affiliation-8"
|
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|
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><sup class="key">8</sup> Haematology Project Foundation, Department of Haematology, S Bortolo Hospital, Vicenza, Italy.</li>
|
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|
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<li data-affiliation-id="full-view-affiliation-9"
|
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id="full-view-affiliation-9"
|
||
><sup class="key">9</sup> Department of Internal Medicine, National Reference Center for Immune Cytopenias, Henri Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris-Est Créteil, Créteil, France.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-10"
|
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id="full-view-affiliation-10"
|
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><sup class="key">10</sup> Centre for Haematology, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, UK.</li>
|
||
|
||
</ul>
|
||
</div>
|
||
|
||
|
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|
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|
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|
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</div>
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|
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|
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|
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|
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|
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<ul class="identifiers" id="full-view-identifiers">
|
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<li>
|
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<span class="identifier pubmed">
|
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<span class="id-label">
|
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|
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PMID:
|
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|
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</span>
|
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|
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|
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<strong class="current-id" title="PubMed ID">37778358</strong>
|
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|
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|
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|
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</span>
|
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|
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|
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<span class="identifier doi">
|
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|
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|
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DOI:
|
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|
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|
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|
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|
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|
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|
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|
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10.1016/S0140-6736(23)01460-5
|
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|
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|
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|
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|
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</span>
|
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|
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|
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|
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|
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|
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<div class="short-view" id="short-view-heading">
|
||
|
||
<div class="publication-type" >Clinical Trial</div>
|
||
|
||
|
||
|
||
|
||
<h1 class="heading-title">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
Efficacy and safety of the neonatal Fc receptor inhibitor efgartigimod in adults with primary immune thrombocytopenia (ADVANCE IV): a multicentre, randomised, placebo-controlled, phase 3 trial
|
||
|
||
|
||
|
||
|
||
</h1>
|
||
|
||
|
||
|
||
<div class="short-citation">
|
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<span class="authors-list">
|
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|
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|
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<span class="authors-list-item "><span class="full-name">Catherine M Broome</span><span class="citation-separator"> et al.</span></span>
|
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|
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|
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</span>
|
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|
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|
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<span class="citation-journal">
|
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Lancet<span class="citation-separator">.</span>
|
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</span>
|
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|
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<span class="date">
|
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<time class="citation-year" datetime="2023">2023</time><span class="citation-separator">.</span>
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|
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</a></li></ul></div></div></div><span class="period">. </span><span class="cit">2023 Nov 4;402(10413):1648-1659.</span>
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ref="linksrc=author_name_link"
|
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|
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|
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data-ga-label="Andrea Patriarca">Andrea Patriarca</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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|
||
ref="linksrc=author_name_link"
|
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|
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|
||
data-ga-label="Simona Tomassetti">Simona Tomassetti</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
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|
||
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|
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|
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|
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data-ga-label="Yoshitaka Miyakawa">Yoshitaka Miyakawa</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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|
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|
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|
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|
||
data-ga-label="Kiyoshi Ando">Kiyoshi Ando</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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|
||
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|
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|
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|
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data-ga-label="Hiroshi Handa">Hiroshi Handa</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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|
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|
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|
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|
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data-ga-label="Shinya Katsutani">Shinya Katsutani</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Nishiwaki+K"
|
||
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|
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|
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|
||
data-ga-label="Kaichi Nishiwaki">Kaichi Nishiwaki</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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|
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|
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|
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|
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data-ga-label="Shoko Ito">Shoko Ito</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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|
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|
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|
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|
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data-ga-label="Tomoki Ito">Tomoki Ito</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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data-ga-label="Maria Soroka-Wojtaszko">Maria Soroka-Wojtaszko</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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data-ga-label="Elena Borisenkova">Elena Borisenkova</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Volodicheva+E"
|
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|
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|
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|
||
data-ga-label="Elena Volodicheva">Elena Volodicheva</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Shatokhin+Y"
|
||
ref="linksrc=author_name_link"
|
||
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|
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|
||
data-ga-label="Yuri Shatokhin">Yuri Shatokhin</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Proydakov+A"
|
||
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|
||
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|
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|
||
data-ga-label="Andrey Proydakov">Andrey Proydakov</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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|
||
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|
||
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|
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|
||
data-ga-label="Maria Aranzazu Alonso">Maria Aranzazu Alonso</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Mingot-Castellano+ME"
|
||
ref="linksrc=author_name_link"
|
||
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|
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|
||
data-ga-label="María Eva Mingot-Castellano">María Eva Mingot-Castellano</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Sanchez-Gonzalez+B"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
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data-ga-action="author_link"
|
||
data-ga-label="Blanca Sanchez-Gonzalez">Blanca Sanchez-Gonzalez</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Valcarcel+Ferreiras+D"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
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data-ga-action="author_link"
|
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data-ga-label="David Valcarcel Ferreiras">David Valcarcel Ferreiras</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Ayli+M"
|
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ref="linksrc=author_name_link"
|
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data-ga-category="search"
|
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|
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data-ga-label="Meltem Ayli">Meltem Ayli</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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|
||
ref="linksrc=author_name_link"
|
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|
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|
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data-ga-label="Tuba Hacibekiroglu">Tuba Hacibekiroglu</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Demir+AM"
|
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|
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|
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|
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data-ga-label="Ahmet Muzaffer Demir">Ahmet Muzaffer Demir</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Nal%C3%A7aci+M"
|
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|
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|
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|
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data-ga-label="Meliha Nalçaci">Meliha Nalçaci</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Sonmez+M"
|
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|
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data-ga-category="search"
|
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|
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data-ga-label="Mehmet Sonmez">Mehmet Sonmez</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Tombak+A"
|
||
ref="linksrc=author_name_link"
|
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data-ga-category="search"
|
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|
||
data-ga-label="Anil Tombak">Anil Tombak</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Toprak+SK"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
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data-ga-action="author_link"
|
||
data-ga-label="Selami Kocak Toprak">Selami Kocak Toprak</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Turgut+B"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
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|
||
data-ga-label="Burhan Turgut">Burhan Turgut</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Vural+F"
|
||
ref="linksrc=author_name_link"
|
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data-ga-category="search"
|
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|
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data-ga-label="Filiz Vural">Filiz Vural</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Yagci+M"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
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|
||
data-ga-label="Munci Yagci">Munci Yagci</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Altuntas+F"
|
||
ref="linksrc=author_name_link"
|
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data-ga-category="search"
|
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data-ga-action="author_link"
|
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data-ga-label="Fevzi Altuntas">Fevzi Altuntas</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Turgut+M"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Mehmet Turgut">Mehmet Turgut</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Kaya+E"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Emin Kaya">Emin Kaya</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Romanyuk+N"
|
||
ref="linksrc=author_name_link"
|
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|
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|
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data-ga-label="Nataliya Romanyuk">Nataliya Romanyuk</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=McDonald+V"
|
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ref="linksrc=author_name_link"
|
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data-ga-category="search"
|
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|
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data-ga-label="Vickie McDonald">Vickie McDonald</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Kazmi+SRS"
|
||
ref="linksrc=author_name_link"
|
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data-ga-category="search"
|
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data-ga-action="author_link"
|
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data-ga-label="Syed Rashid Saeed Kazmi">Syed Rashid Saeed Kazmi</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Broome+C"
|
||
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|
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|
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|
||
data-ga-label="Catherine Broome">Catherine Broome</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Cataland+S"
|
||
ref="linksrc=author_name_link"
|
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data-ga-category="search"
|
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data-ga-action="author_link"
|
||
data-ga-label="Spero Cataland">Spero Cataland</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Doshi+K"
|
||
ref="linksrc=author_name_link"
|
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data-ga-category="search"
|
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|
||
data-ga-label="Ketan Doshi">Ketan Doshi</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Lentz+SR"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Steven R Lentz">Steven R Lentz</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Boxer+M"
|
||
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|
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|
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|
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data-ga-label="Michael Boxer">Michael Boxer</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Rosenberg+R"
|
||
ref="linksrc=author_name_link"
|
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data-ga-category="search"
|
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data-ga-action="author_link"
|
||
data-ga-label="Richard Rosenberg">Richard Rosenberg</a></span>
|
||
</div>
|
||
|
||
|
||
</li>
|
||
|
||
</ul>
|
||
</div>
|
||
|
||
|
||
|
||
<div class="affiliations">
|
||
<h3 class="title">
|
||
Affiliations
|
||
</h3>
|
||
<ul class="item-list">
|
||
|
||
<li data-affiliation-id="short-view-affiliation-1"
|
||
id="short-view-affiliation-1"
|
||
><sup class="key">1</sup> Lombardi Cancer Center, Division of Hematology, Georgetown University, Washington, DC, USA. Electronic address: catherine.m.broome@gunet.georgetown.edu.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-2"
|
||
id="short-view-affiliation-2"
|
||
><sup class="key">2</sup> Department of Clinical Haematology, Barts Health NHS Trust, London, UK.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-3"
|
||
id="short-view-affiliation-3"
|
||
><sup class="key">3</sup> Department of Hematology, Saitama Medical University Hospital, Saitama, Japan.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-4"
|
||
id="short-view-affiliation-4"
|
||
><sup class="key">4</sup> Hematology and Transplant Unit, UOC Hematology and Transplant Unit Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-5"
|
||
id="short-view-affiliation-5"
|
||
><sup class="key">5</sup> Hematology Division, Massachusetts General Hospital, Boston, MA, USA.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-6"
|
||
id="short-view-affiliation-6"
|
||
><sup class="key">6</sup> Division of Hematology and Medical Oncology and Division of Pediatric Hematology and Oncology, Weill Cornell Medical College, New York, NY, USA.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-7"
|
||
id="short-view-affiliation-7"
|
||
><sup class="key">7</sup> argenx, Ghent, Belgium.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-8"
|
||
id="short-view-affiliation-8"
|
||
><sup class="key">8</sup> Haematology Project Foundation, Department of Haematology, S Bortolo Hospital, Vicenza, Italy.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-9"
|
||
id="short-view-affiliation-9"
|
||
><sup class="key">9</sup> Department of Internal Medicine, National Reference Center for Immune Cytopenias, Henri Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris-Est Créteil, Créteil, France.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-10"
|
||
id="short-view-affiliation-10"
|
||
><sup class="key">10</sup> Centre for Haematology, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, UK.</li>
|
||
|
||
</ul>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<ul class="identifiers" id="short-view-identifiers">
|
||
|
||
<li>
|
||
<span class="identifier pubmed">
|
||
<span class="id-label">
|
||
|
||
PMID:
|
||
|
||
</span>
|
||
|
||
|
||
<strong class="current-id" title="PubMed ID">37778358</strong>
|
||
|
||
|
||
|
||
</span>
|
||
|
||
</li>
|
||
|
||
<li>
|
||
<span class="identifier doi">
|
||
<span class="id-label">
|
||
|
||
DOI:
|
||
|
||
</span>
|
||
|
||
|
||
<a class="id-link"
|
||
target="_blank"
|
||
rel="noopener"
|
||
ref="linksrc=article_id_link&article_id=10.1016/S0140-6736(23)01460-5&id_type=DOI"
|
||
href="https://doi.org/10.1016/s0140-6736(23)01460-5"
|
||
data-ga-category="full_text"
|
||
data-ga-action="DOI"
|
||
>
|
||
10.1016/S0140-6736(23)01460-5
|
||
</a>
|
||
|
||
|
||
|
||
</span>
|
||
|
||
</li>
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
<div class="in-clipboard-label " hidden>
|
||
Item in Clipboard
|
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</div>
|
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</div>
|
||
</div>
|
||
|
||
|
||
</header>
|
||
|
||
|
||
|
||
<div class="actions-buttons inline"><div class="inner-wrap"><button class="full-text-links-button full-text-links-dialog-trigger"
|
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title="Open dialog with full text links"
|
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ref="linksrc=full_text_links">
|
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Full text links
|
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</button><button class="citation-button citation-dialog-trigger"
|
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aria-label="Open dialog with citation text in different styles"
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Abstract
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<strong class="sub-title">
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Background:
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Primary immune thrombocytopenia is an autoimmune disorder mediated partly by platelet autoantibodies, resulting in thrombocytopenia, bleeding, and constitutional symptoms. Efgartigimod, a first-in-class novel human IgG1 Fc fragment, binds the neonatal Fc receptor with high affinity and thus reduces serum IgG concentrations, including autoantibodies. The objective of this study was to evaluate the efficacy and safety of efgartigimod in adults with persistent and chronic primary immune thrombocytopenia.
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<strong class="sub-title">
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Methods:
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This phase 3, multicentre, randomised, double-blinded, placebo-controlled, 24-week study evaluated the efficacy and safety of intravenous efgartigimod in adults aged 18 years or older with chronic or persistent primary immune thrombocytopenia who had an average platelet count of less than 30 000, had responded to at least one previous immune thrombocytopenia therapy, and were on a concurrent therapy at baseline or had received at least a second previous immune thrombocytopenia therapy. The study took place in 71 participating sites from Asia, Europe, and North America. Patients were randomly assigned 2:1 to receive either efgartigimod (10 mg/kg) or placebo intravenously for the first 4 weeks, after which the dosing schedule could be altered to once per week or every other week depending on the patients' platelet count. The primary endpoint, evaluated in the chronic population, was sustained platelet count response (≥50 × 10<sup>9</sup> for at least 4 of the last 6 weeks). This study is registered with ClinicalTrials.gov (<a href="http://clinicaltrials.gov/show/NCT04188379" title="See in ClinicalTrials.gov">NCT04188379</a>) and is completed.
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<strong class="sub-title">
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Findings:
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</strong>
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A total of 205 patients were screened from Dec 9, 2019, to Feb 3, 2022, and 131 (86 in the efgartigimod group; 45 in the placebo group) were randomly assigned. These patients represented a population with long-term disease who had a mean time since diagnosis of 10·6 years and 67% (88/131) of whom had received at least three previous immune thrombocytopenia treatments. 22% (17/78) of patients with chronic immune thrombocytopenia receiving efgartigimod reached the primary endpoint compared with 5% (2/40) of those receiving placebo (p=0·032; adjusted difference in response, 16% [95% CI 2·6-26·4]). The median number of weeks of disease control in patients with chronic immune thrombocytopenia was 2·0 (IQR 0·0-11·0) for efgartigimod versus 0·0 (0·0-1·0) for placebo (p=0·0009). Efgartigimod was well tolerated; most adverse events were mild to moderate in severity. The most common adverse events of interest in both groups were headache (16% in efgartigimod and 13% in placebo), haematuria (16% in efgartigimod and 16% in placebo), and petechiae (15% in efgartigimod and 27% in placebo).
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</p>
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<p>
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<strong class="sub-title">
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Interpretation:
|
||
</strong>
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Efgartigimod significantly increased sustained platelet count responses compared with placebo in patients with chronic immune thrombocytopenia, including those who had received multiple previous immune thrombocytopenia therapies. Upon completion of the ADVANCE IV study, patients could enroll in the ongoing open-label extension. Subcutaneous efgartigimod is currently being evaluated in patients with immune thrombocytopenia in the ADVANCE SC+ trial.
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</p>
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<p>
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<strong class="sub-title">
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Funding:
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</strong>
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argenx.
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</p>
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<p class="copyright" id="copyright">
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Copyright © 2023 Elsevier Ltd. All rights reserved.
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<div class="conflict-of-interest" id="conflict-of-interest">
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<h2 class="title">
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||
Conflict of interest statement
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||
</h2>
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||
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||
<div class="statement">
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||
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||
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<p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">Declaration of interests CMB reports honoraria from Alexion, Apellis, argenx, and Sanofi; and advisory fees from Novartis and Incyte. VM reports consulting or advisory fees from Amgen, Novartis, and Sobi; and research grants from Grifols and Rigel. YM reports consulting or advisory fees from argenx, Kyowa Kirin, UCB, and Zenyaku Kogyo; and honoraria from Alexion, Chugai, Pfizer, and Sanofi. MC reports consulting or advisory fees from Amgen, argenx, and Novartis; and honoraria from Sobi. DJK reports grant support from argenx, Biocryst, Immunovant, Principia, Rigel, Takeda (Bioverativ), and UCB; consulting or advisory fees from Alexion (Syntimmune), Amgen, argenx, BioCryst, Bristol-Myers Squibb, Caremark, Cellphire, Cellularity, CRICO, Daiichi Sankyo, Hengrui, Immunovant, Incyte, Kyowa Kirin, Merck Sharp Dohme, Momenta, Novartis, Pfizer, Platelet Biogenesis, Platelet Disorder Support Association, Rigel, Sanofi (Bioveratif), Sanofi (Genzyme), Sanofi (Principia), Sobi (Dova), Takeda, UCB, and Up-To-Date; and stock ownership benefits from Rubius. HA-S reports grant support from Agios, Amgen, Novartis, Sobi, and Vaderis; and consulting or advisory fees from Agios, argenx, Forma, Moderna, Novartis, Rigel, and Sobi. JBB reports advisory fees from Amgen, argenx, AstraZeneca, Janssen, Novartis, Rigel, Sanofi, Sobi, and UCB; and data and safety monitoring fees from UCB. MG reports employment by argenx. JA reports employment by argenx. KDB reports employment by argenx. FR reports consulting or advisory fees from Amgen, argenx, Novartis, and UCB. MM reports consulting or advisory and speaker fees from Alexion, argenx, Novartis, Sanofi, and Sobi. AN reports honoraria from Amgen, Angle, argenx, Dova, Novartis, Ono, Rigel, and Shionogi; grant funding from Amgen, Novartis, and Rigel; expert testimony fees from argenx and Rigel; and consulting or advisory fees from Amgen, Angle, argenx, Dova, Novartis, Ono, Rigel, and Shionogi.</p>
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</div>
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</div>
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|
||
<div class="docsum-citation full-citation">
|
||
|
||
|
||
|
||
<span class="docsum-authors full-authors">Zhang H, Ma J, Feng Y, Ma H, Liu D, Pang X, Chang X, Zhao R, Wang J, Guo J, Zhang W.</span>
|
||
|
||
|
||
|
||
<span class="docsum-authors short-authors">Zhang H, et al.</span>
|
||
<span class="docsum-journal-citation full-journal-citation">J Neurol. 2024 Jun;271(6):3506-3511. doi: 10.1007/s00415-024-12321-4. Epub 2024 Mar 26.</span>
|
||
<span class="docsum-journal-citation short-journal-citation">J Neurol. 2024.</span>
|
||
|
||
|
||
<span class="citation-part">PMID: <span class="docsum-pmid">38532142</span></span>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</li>
|
||
|
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|
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|
||
|
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|
||
|
||
|
||
|
||
|
||
|
||
<li class="full-docsum">
|
||
|
||
<div class="docsum-content" style="display:inline;">
|
||
<a class="docsum-title"
|
||
href="/39051412/"
|
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ref="article_id=39051412&linksrc=citedby_articles_link&ordinalpos=3"
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|
||
Treatment of Immune Thrombocytopenia: Contextualization from a Historical Perspective.
|
||
|
||
</a>
|
||
<div class="docsum-citation full-citation">
|
||
|
||
|
||
|
||
<span class="docsum-authors full-authors">Martínez-Carballeira D, Bernardo Á, Caro A, Soto I, Gutiérrez L.</span>
|
||
|
||
|
||
|
||
<span class="docsum-authors short-authors">Martínez-Carballeira D, et al.</span>
|
||
<span class="docsum-journal-citation full-journal-citation">Hematol Rep. 2024 Jun 26;16(3):390-412. doi: 10.3390/hematolrep16030039.</span>
|
||
<span class="docsum-journal-citation short-journal-citation">Hematol Rep. 2024.</span>
|
||
|
||
|
||
<span class="citation-part">PMID: <span class="docsum-pmid">39051412</span></span>
|
||
<span class="free-resources spaced-citation-item citation-part">Free PMC article.</span>
|
||
|
||
|
||
|
||
<span class="publication-type spaced-citation-item citation-part">Review.</span>
|
||
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</li>
|
||
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||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<li class="full-docsum">
|
||
|
||
<div class="docsum-content" style="display:inline;">
|
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<a class="docsum-title"
|
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href="/39004663/"
|
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The function of long non-coding RNA IFNG-AS1 in autoimmune diseases.
|
||
|
||
</a>
|
||
<div class="docsum-citation full-citation">
|
||
|
||
|
||
|
||
<span class="docsum-authors full-authors">Zhao J, Gui Y, Wu W, Li X, Wang L, Wang H, Luo Y, Zhou G, Yuan C.</span>
|
||
|
||
|
||
|
||
<span class="docsum-authors short-authors">Zhao J, et al.</span>
|
||
<span class="docsum-journal-citation full-journal-citation">Hum Cell. 2024 Sep;37(5):1325-1335. doi: 10.1007/s13577-024-01103-9. Epub 2024 Jul 14.</span>
|
||
<span class="docsum-journal-citation short-journal-citation">Hum Cell. 2024.</span>
|
||
|
||
|
||
<span class="citation-part">PMID: <span class="docsum-pmid">39004663</span></span>
|
||
|
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|
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<span class="publication-type spaced-citation-item citation-part">Review.</span>
|
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|
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|
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</div>
|
||
|
||
</div>
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|
||
</li>
|
||
|
||
|
||
|
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|
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|
||
|
||
|
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|
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|
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|
||
<li class="full-docsum">
|
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<div class="docsum-content" style="display:inline;">
|
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<a class="docsum-title"
|
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href="/39543164/"
|
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Systemic capillary leak syndrome.
|
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<div class="docsum-citation full-citation">
|
||
|
||
|
||
|
||
<span class="docsum-authors full-authors">Druey KM, Arnaud L, Parikh SM.</span>
|
||
|
||
|
||
|
||
<span class="docsum-authors short-authors">Druey KM, et al.</span>
|
||
<span class="docsum-journal-citation full-journal-citation">Nat Rev Dis Primers. 2024 Nov 14;10(1):86. doi: 10.1038/s41572-024-00571-5.</span>
|
||
<span class="docsum-journal-citation short-journal-citation">Nat Rev Dis Primers. 2024.</span>
|
||
|
||
|
||
<span class="citation-part">PMID: <span class="docsum-pmid">39543164</span></span>
|
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|
||
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||
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||
|
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<span class="publication-type spaced-citation-item citation-part">Review.</span>
|
||
|
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|
||
</div>
|
||
|
||
</div>
|
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</li>
|
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|
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|
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|
||
<div id="publication-types" class="publication-types keywords-section">
|
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<h2 class="title">
|
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Publication types
|
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</h2>
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<ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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Clinical Trial, Phase III
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data-pinger-ignore>
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Multicenter Study
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class="keyword-actions-dropdown dropdown dropdown-container"
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aria-label="Dropdown menu for keyword Multicenter Study"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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Randomized Controlled Trial
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<div id="mesh-terms" class="mesh-terms keywords-section">
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<h2 class="title">
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MeSH terms
|
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</h2>
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role="button"
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||
data-search-term=""Double-Blind Method"[MeSH]"
|
||
data-ga-category="search"
|
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data-ga-action="add_to_search"
|
||
data-ga-label=""Double-Blind Method"[MeSH]"
|
||
href="#">
|
||
Add to Search
|
||
</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword Humans"
|
||
tabindex="0"
|
||
aria-controls="keyword-actions-mesh-terms-3"
|
||
aria-expanded="false"
|
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data-pinger-ignore>
|
||
Humans
|
||
</button><div id="keyword-actions-mesh-terms-3"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
||
aria-label="Dropdown menu for keyword Humans"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc"
|
||
ref="linksrc=search_in_pubmed_keyword_link&mesh="Humans"[MeSH]"
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data-ga-category="search"
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data-ga-action="mesh_term"
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data-ga-label="Humans">
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Search in PubMed
|
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
||
ref="linksrc=search_in_mesh_link"
|
||
href="https://www.ncbi.nlm.nih.gov/mesh?term=Humans"
|
||
data-ga-category="search_mesh"
|
||
data-ga-action="mesh_term_link"
|
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data-ga-label="Humans">
|
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Search in MeSH
|
||
</a></li><li><a class="add-to-search-link dropdown-block-link"
|
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ref="linksrc=add_to_search_link"
|
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role="button"
|
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data-search-term=""Humans"[MeSH]"
|
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data-ga-category="search"
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data-ga-action="add_to_search"
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data-ga-label=""Humans"[MeSH]"
|
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href="#">
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword Platelet Count"
|
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tabindex="0"
|
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aria-controls="keyword-actions-mesh-terms-4"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Platelet Count
|
||
</button><div id="keyword-actions-mesh-terms-4"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
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aria-label="Dropdown menu for keyword Platelet Count"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Platelet+Count%22%5BMeSH%5D&sort=date&sort_order=desc"
|
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data-href="/?term=%22Platelet+Count%22%5BMeSH%5D&sort=date&sort_order=desc"
|
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Platelet Count"[MeSH]"
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data-ga-category="search"
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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ref="linksrc=search_in_mesh_link"
|
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Platelet+Count"
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data-ga-category="search_mesh"
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data-ga-action="mesh_term_link"
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data-ga-label="Platelet Count">
|
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Search in MeSH
|
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</a></li><li><a class="add-to-search-link dropdown-block-link"
|
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ref="linksrc=add_to_search_link"
|
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role="button"
|
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data-search-term=""Platelet Count"[MeSH]"
|
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data-ga-category="search"
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data-ga-action="add_to_search"
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data-ga-label=""Platelet Count"[MeSH]"
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href="#">
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major"
|
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aria-label="Toggle dropdown menu for keyword Purpura, Thrombocytopenic, Idiopathic* / drug therapy"
|
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tabindex="0"
|
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aria-controls="keyword-actions-mesh-terms-major-5"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Purpura, Thrombocytopenic, Idiopathic* / drug therapy
|
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</button><div id="keyword-actions-mesh-terms-major-5"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
|
||
hidden
|
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aria-label="Dropdown menu for keyword Purpura, Thrombocytopenic, Idiopathic* / drug therapy"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Purpura%2C+Thrombocytopenic%2C+Idiopathic%2Fdrug+therapy%22%5BMAJR%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22Purpura%2C+Thrombocytopenic%2C+Idiopathic%2Fdrug+therapy%22%5BMAJR%5D&sort=date&sort_order=desc"
|
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Purpura, Thrombocytopenic, Idiopathic/drug therapy"[MAJR]"
|
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data-ga-category="search"
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data-ga-action="mesh_term"
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data-ga-label="Purpura, Thrombocytopenic, Idiopathic* / drug therapy">
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Search in PubMed
|
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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ref="linksrc=search_in_mesh_link"
|
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Purpura%2C+Thrombocytopenic%2C+Idiopathic"
|
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data-ga-category="search_mesh"
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data-ga-label="Purpura, Thrombocytopenic, Idiopathic* / drug therapy">
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Search in MeSH
|
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</a></li><li><a class="add-to-search-link dropdown-block-link"
|
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ref="linksrc=add_to_search_link"
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role="button"
|
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data-search-term=""Purpura, Thrombocytopenic, Idiopathic/drug therapy"[MAJR]"
|
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data-ga-category="search"
|
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data-ga-action="add_to_search"
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data-ga-label=""Purpura, Thrombocytopenic, Idiopathic/drug therapy"[MAJR]"
|
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href="#">
|
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Add to Search
|
||
</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword Receptors, Fc / therapeutic use"
|
||
tabindex="0"
|
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aria-controls="keyword-actions-mesh-terms-6"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Receptors, Fc / therapeutic use
|
||
</button><div id="keyword-actions-mesh-terms-6"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
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aria-label="Dropdown menu for keyword Receptors, Fc / therapeutic use"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
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href="/?term=%22Receptors%2C+Fc%2Ftherapeutic+use%22%5BMeSH%5D&sort=date&sort_order=desc"
|
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data-href="/?term=%22Receptors%2C+Fc%2Ftherapeutic+use%22%5BMeSH%5D&sort=date&sort_order=desc"
|
||
ref="linksrc=search_in_pubmed_keyword_link&mesh="Receptors, Fc/therapeutic use"[MeSH]"
|
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data-ga-category="search"
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data-ga-action="mesh_term"
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data-ga-label="Receptors, Fc / therapeutic use">
|
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Search in PubMed
|
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
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ref="linksrc=search_in_mesh_link"
|
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Receptors%2C+Fc"
|
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data-ga-category="search_mesh"
|
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data-ga-action="mesh_term_link"
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data-ga-label="Receptors, Fc / therapeutic use">
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Search in MeSH
|
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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ref="linksrc=add_to_search_link"
|
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role="button"
|
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data-search-term=""Receptors, Fc/therapeutic use"[MeSH]"
|
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data-ga-category="search"
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data-ga-action="add_to_search"
|
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data-ga-label=""Receptors, Fc/therapeutic use"[MeSH]"
|
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href="#">
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major"
|
||
aria-label="Toggle dropdown menu for keyword Thrombocytopenia* / chemically induced"
|
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tabindex="0"
|
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aria-controls="keyword-actions-mesh-terms-major-7"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Thrombocytopenia* / chemically induced
|
||
</button><div id="keyword-actions-mesh-terms-major-7"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
||
hidden
|
||
aria-label="Dropdown menu for keyword Thrombocytopenia* / chemically induced"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Thrombocytopenia%2Fchemically+induced%22%5BMAJR%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22Thrombocytopenia%2Fchemically+induced%22%5BMAJR%5D&sort=date&sort_order=desc"
|
||
ref="linksrc=search_in_pubmed_keyword_link&mesh="Thrombocytopenia/chemically induced"[MAJR]"
|
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data-ga-category="search"
|
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data-ga-action="mesh_term"
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data-ga-label="Thrombocytopenia* / chemically induced">
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Search in PubMed
|
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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ref="linksrc=search_in_mesh_link"
|
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Thrombocytopenia"
|
||
data-ga-category="search_mesh"
|
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data-ga-action="mesh_term_link"
|
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data-ga-label="Thrombocytopenia* / chemically induced">
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Search in MeSH
|
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</a></li><li><a class="add-to-search-link dropdown-block-link"
|
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ref="linksrc=add_to_search_link"
|
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role="button"
|
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data-search-term=""Thrombocytopenia/chemically induced"[MAJR]"
|
||
data-ga-category="search"
|
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data-ga-action="add_to_search"
|
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data-ga-label=""Thrombocytopenia/chemically induced"[MAJR]"
|
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href="#">
|
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major"
|
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aria-label="Toggle dropdown menu for keyword Thrombocytopenia* / drug therapy"
|
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tabindex="0"
|
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aria-controls="keyword-actions-mesh-terms-major-8"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Thrombocytopenia* / drug therapy
|
||
</button><div id="keyword-actions-mesh-terms-major-8"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
||
hidden
|
||
aria-label="Dropdown menu for keyword Thrombocytopenia* / drug therapy"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Thrombocytopenia%2Fdrug+therapy%22%5BMAJR%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22Thrombocytopenia%2Fdrug+therapy%22%5BMAJR%5D&sort=date&sort_order=desc"
|
||
ref="linksrc=search_in_pubmed_keyword_link&mesh="Thrombocytopenia/drug therapy"[MAJR]"
|
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data-ga-category="search"
|
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data-ga-action="mesh_term"
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data-ga-label="Thrombocytopenia* / drug therapy">
|
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Search in PubMed
|
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
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ref="linksrc=search_in_mesh_link"
|
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Thrombocytopenia"
|
||
data-ga-category="search_mesh"
|
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data-ga-action="mesh_term_link"
|
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data-ga-label="Thrombocytopenia* / drug therapy">
|
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Search in MeSH
|
||
</a></li><li><a class="add-to-search-link dropdown-block-link"
|
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ref="linksrc=add_to_search_link"
|
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role="button"
|
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data-search-term=""Thrombocytopenia/drug therapy"[MAJR]"
|
||
data-ga-category="search"
|
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data-ga-action="add_to_search"
|
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data-ga-label=""Thrombocytopenia/drug therapy"[MAJR]"
|
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href="#">
|
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
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aria-label="Toggle dropdown menu for keyword Treatment Outcome"
|
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tabindex="0"
|
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aria-controls="keyword-actions-mesh-terms-9"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Treatment Outcome
|
||
</button><div id="keyword-actions-mesh-terms-9"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
||
aria-label="Dropdown menu for keyword Treatment Outcome"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Treatment+Outcome%22%5BMeSH%5D&sort=date&sort_order=desc"
|
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data-href="/?term=%22Treatment+Outcome%22%5BMeSH%5D&sort=date&sort_order=desc"
|
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Treatment Outcome"[MeSH]"
|
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data-ga-category="search"
|
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data-ga-action="mesh_term"
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data-ga-label="Treatment Outcome">
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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ref="linksrc=search_in_mesh_link"
|
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Treatment+Outcome"
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data-ga-category="search_mesh"
|
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data-ga-action="mesh_term_link"
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data-ga-label="Treatment Outcome">
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Search in MeSH
|
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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ref="linksrc=add_to_search_link"
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role="button"
|
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data-search-term=""Treatment Outcome"[MeSH]"
|
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data-ga-category="search"
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data-ga-action="add_to_search"
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data-ga-label=""Treatment Outcome"[MeSH]"
|
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href="#">
|
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Add to Search
|
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</a></li></ul></div></div></div></li></ul>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
<div id="substances" class="substances keywords-section">
|
||
<h2 class="title">
|
||
Substances
|
||
</h2>
|
||
|
||
<ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword Autoantibodies"
|
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tabindex="0"
|
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aria-controls="keyword-actions-substances-0"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
||
Autoantibodies
|
||
</button><div id="keyword-actions-substances-0"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
||
aria-label="Dropdown menu for keyword Autoantibodies"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Autoantibodies%22%5Bnm%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22Autoantibodies%22%5Bnm%5D&sort=date&sort_order=desc"
|
||
ref="linksrc=search_in_pubmed_keyword_link&keyword="Autoantibodies"[nm]"
|
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data-ga-category="search"
|
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data-ga-action="substance"
|
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data-ga-label="Autoantibodies">
|
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Search in PubMed
|
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
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ref="linksrc=search_in_mesh_link"
|
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href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Autoantibodies%22"
|
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data-ga-category="search_mesh"
|
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data-ga-action="substance_link"
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data-ga-label="Autoantibodies">
|
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Search in MeSH
|
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</a></li><li><a class="add-to-search-link dropdown-block-link"
|
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ref="linksrc=add_to_search_link"
|
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role="button"
|
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data-search-term=""Autoantibodies"[nm]"
|
||
data-ga-category="search"
|
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data-ga-action="add_to_search"
|
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data-ga-label=""Autoantibodies"[nm]"
|
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href="#">
|
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
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aria-label="Toggle dropdown menu for keyword Fc receptor, neonatal"
|
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tabindex="0"
|
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aria-controls="keyword-actions-substances-1"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Fc receptor, neonatal
|
||
</button><div id="keyword-actions-substances-1"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
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aria-label="Dropdown menu for keyword Fc receptor, neonatal"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Fc+receptor%2C+neonatal%22%5Bnm%5D&sort=date&sort_order=desc"
|
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data-href="/?term=%22Fc+receptor%2C+neonatal%22%5Bnm%5D&sort=date&sort_order=desc"
|
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ref="linksrc=search_in_pubmed_keyword_link&keyword="Fc receptor, neonatal"[nm]"
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data-ga-category="search"
|
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data-ga-action="substance"
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data-ga-label="Fc receptor, neonatal">
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
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ref="linksrc=search_in_mesh_link"
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href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Fc+receptor%2C+neonatal%22"
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data-ga-category="search_mesh"
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data-ga-action="substance_link"
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data-ga-label="Fc receptor, neonatal">
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Search in MeSH
|
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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ref="linksrc=add_to_search_link"
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|
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data-search-term=""Fc receptor, neonatal"[nm]"
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data-ga-category="search"
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data-ga-action="add_to_search"
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data-ga-label=""Fc receptor, neonatal"[nm]"
|
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href="#">
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
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aria-label="Toggle dropdown menu for keyword Receptors, Fc"
|
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tabindex="0"
|
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aria-controls="keyword-actions-substances-2"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Receptors, Fc
|
||
</button><div id="keyword-actions-substances-2"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
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aria-label="Dropdown menu for keyword Receptors, Fc"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
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href="/?term=%22Receptors%2C+Fc%22%5Bnm%5D&sort=date&sort_order=desc"
|
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data-href="/?term=%22Receptors%2C+Fc%22%5Bnm%5D&sort=date&sort_order=desc"
|
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ref="linksrc=search_in_pubmed_keyword_link&keyword="Receptors, Fc"[nm]"
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data-ga-category="search"
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data-ga-action="substance"
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data-ga-label="Receptors, Fc">
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Search in PubMed
|
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
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ref="linksrc=search_in_mesh_link"
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href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Receptors%2C+Fc%22"
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data-ga-category="search_mesh"
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data-ga-action="substance_link"
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data-ga-label="Receptors, Fc">
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Search in MeSH
|
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</a></li><li><a class="add-to-search-link dropdown-block-link"
|
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ref="linksrc=add_to_search_link"
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role="button"
|
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data-search-term=""Receptors, Fc"[nm]"
|
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data-ga-category="search"
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data-ga-action="add_to_search"
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data-ga-label=""Receptors, Fc"[nm]"
|
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href="#">
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Add to Search
|
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</a></li></ul></div></div></div></li></ul>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
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