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<meta name="description" content="Artemether appears to be more effective than quinine in children and adults. Artemether compared to artesunate has not been extensively studied, but in adults it appears inferior. These findings are consistent with the WHO recommendations that artesunate is the drug of choice, but artemether is acce …"><meta name="keywords" content="pmid:31210357, PMC6580442, doi:10.1002/14651858.CD010678.pub3, Meta-Analysis, Research Support, Non-U.S. Gov&#x27;t, Systematic Review, Ekpereonne B Esu, Emmanuel E Effa, Martin M Meremikwu, Adolescent, Adult, Africa, Age Factors, Antimalarials / administration &amp; dosage*, Antimalarials / adverse effects, Artemether / administration &amp; dosage*, Artemether / adverse effects, Artesunate / administration &amp; dosage, Artesunate / adverse effects, Asia, Child, Child, Preschool, Coma / drug therapy, Fever / drug therapy, Humans, Infant, Injections, Intramuscular / mortality, Malaria, Cerebral / drug therapy, Malaria, Cerebral / mortality, Malaria, Falciparum / drug therapy*, Malaria, Falciparum / mortality, Oceania, Quinine / administration &amp; dosage, Quinine / adverse effects, Randomized Controlled Trials as Topic, Treatment Outcome, PubMed Abstract, NIH, NLM, NCBI, National Institutes of Health, National Center for Biotechnology Information, National Library of Medicine, MEDLINE"><meta name="robots" content="index,nofollow,noarchive"><meta property="og:title" content="Artemether for severe malaria - PubMed"><meta property="og:url" content="https://pubmed.ncbi.nlm.nih.gov/31210357/"><meta property="og:description" content="Artemether appears to be more effective than quinine in children and adults. Artemether compared to artesunate has not been extensively studied, but in adults it appears inferior. These findings are consistent with the WHO recommendations that artesunate is the drug of choice, but artemether is acce …"><meta property="og:image" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg"><meta property="og:image:secure_url" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg"><meta property="og:type" content="website"><meta property="og:site_name" content="PubMed"><meta name="twitter:domain" content="pubmed.ncbi.nlm.nih.gov"><meta name="twitter:card" content="summary_large_image"><meta name="twitter:title" content="Artemether for severe malaria - PubMed"><meta name="twitter:url" content="https://pubmed.ncbi.nlm.nih.gov/31210357/"><meta name="twitter:description" content="Artemether appears to be more effective than quinine in children and adults. Artemether compared to artesunate has not been extensively studied, but in adults it appears inferior. These findings are consistent with the WHO recommendations that artesunate is the drug of choice, but artemether is acce …"><meta name="twitter:image" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg">
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<input type="email" aria-label="Sender Email Address" placeholder="email@example.com" id="email-from" class="email-from" pattern="^[a-zA-Z0-9_.+-]+@[a-zA-Z0-9-]+\.[a-zA-Z0-9-.]+$" maxlength="256">
</div>
<div class="action-panel-control-wrap">
<label for="email-citation-format" class="action-panel-label">
Format:
</label>
<select id="email-citation-format" name="citation-format" class="action-panel-selector email-citation-format">
<option selected="selected" value="summary">Summary</option>
<option value="summary-text">Summary (text)</option>
<option value="abstract">Abstract</option>
<option value="abstract-text">Abstract (text)</option>
</select>
</div>
<div class="include-supplemental-container">
<input type="checkbox" aria-label="Include MeSH and other data" name="include-supplemental" id="email-include-supplemental" class="email-include-supplemental">
<label for="email-include-supplemental" class="email-include-supplemental-label">MeSH and other data</label>
</div>
<div class="form-field recaptcha ">
<div class="g-recaptcha" id="id-recaptcha" data-sitekey="6LfsWHMdAAAAAClKbtOpjQ2pMjgsGxvv7NdZW9uI"></div>
</div>
<div id="captcha-error-message" class="usa-input-error-message captcha-validation-message" role="alert"></div>
<div class="action-panel-actions">
<button class="action-panel-submit"
type="submit"
data-loading-label="Sending..."
data-ga-category="save_share"
data-ga-action="email"
data-ga-label="send">
Send email
</button>
<button class="action-panel-cancel"
aria-label="Close 'Email citations' panel"
ref="linksrc=close_email_panel"
aria-controls="email-action-panel"
aria-expanded="false"
data-ga-category="save_share"
data-ga-action="email"
data-ga-label="cancel">
Cancel
</button>
</div>
<input type="hidden" name="email-search-details" value="" />
<input type="hidden" name="email-search-details-hash" value="0e42663a6c3bd85498fcb88798998fed7bfdc45d457db35281e41afe13cc0524" />
</form>
</div>
</div>
<div id="collections-action-panel"
class="collections-action-panel action-panel in-progress-dots-panel"
aria-hidden="true"
data-collections-open-panel-enabled="false"
data-collections-open-panel-url-hash="#open-collections-panel">
<div class="inner-wrap">
<h3 class="action-panel-heading">
Add to Collections
</h3>
<form id="collections-action-panel-form"
class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
data-existing-collections-url="/list-existing-collections/"
data-add-to-existing-collection-url="/add-to-existing-collection/"
data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/"
data-get-article-ids-by-search-url="/get-article-ids-by-search/"
data-myncbi-max-collection-name-length="100"
data-add-to-collection-max-amount="1000"
data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/">
<input type="hidden" name="csrfmiddlewaretoken" value="ZLeiskFVEsKKhgUNI2Tovk7s9gLtbaN8gyYn5a8he3xebH0DllwqZsD6HktF4Lls">
<div class="choice-group" role="radiogroup">
<ul class="radio-group-items">
<li>
<input type="radio"
id="collections-action-panel-new"
class="collections-new"
name="collections"
value="new"
data-ga-category="save_share"
data-ga-action="collections"
data-ga-label="collections_radio_new">
<label for="collections-action-panel-new">Create a new collection</label>
</li>
<li>
<input type="radio"
id="collections-action-panel-existing"
class="collections-existing"
name="collections"
value="existing"
checked="true"
data-ga-category="save_share"
data-ga-action="collections"
data-ga-label="collections_radio_existing">
<label for="collections-action-panel-existing">Add to an existing collection</label>
</li>
</ul>
</div>
<div class="controls-wrapper">
<div class="action-panel-control-wrap new-collections-controls">
<label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk">
Name your collection:
</label>
<input
type="text"
name="add-to-new-collection"
id="collections-action-panel-add-to-new"
class="collections-action-add-to-new"
pattern="[^&quot;&amp;=&lt;&gt;\/]*" title="The following characters are not allowed in the Name field: &quot;&amp;=&lt;&gt;/"
maxlength="100"
data-ga-category="save_share"
data-ga-action="create_collection"
data-ga-label="non_favorties_collection">
<div class="collections-new-name-too-long usa-input-error-message selection-validation-message">
Name must be less than 100 characters
</div>
</div>
<div class="action-panel-control-wrap existing-collections-controls">
<label for="collections-action-panel-add-to-existing" class="action-panel-label">
Choose a collection:
</label>
<select id="collections-action-panel-add-to-existing"
class="action-panel-selector collections-action-add-to-existing"
data-ga-category="save_share"
data-ga-action="select_collection"
data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'">
</select>
<div class="collections-retry-load-on-error usa-input-error-message selection-validation-message">
Unable to load your collection due to an error<br>
<a href="#">Please try again</a>
</div>
</div>
</div>
<div class="action-panel-actions">
<button class="action-panel-submit"
type="submit"
data-loading-label="Adding..."
data-pinger-ignore
data-ga-category="save_share"
data-ga-action="collections"
data-ga-label="add">
Add
</button>
<button class="action-panel-cancel"
aria-label="Close 'Add to Collections' panel"
ref="linksrc=close_collections_panel"
aria-controls="collections-action-panel"
aria-expanded="false"
data-ga-category="save_share"
data-ga-action="collections"
data-ga-label="cancel">
Cancel
</button>
</div>
</form>
</div>
</div>
<div id="bibliography-action-panel"
class="bibliography-action-panel action-panel in-progress-dots-panel"
aria-hidden="true"
data-bibliography-open-panel-enabled="false"
data-bibliography-open-panel-url-hash="#open-bibliography-panel">
<div class="inner-wrap">
<h3 class="action-panel-heading">
Add to My Bibliography
</h3>
<form id="bibliography-action-panel-form"
class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
data-add-to-bibliography-max-amount="100"
data-add-to-bibliography-batch-size="10"
data-bibliography-delegates-url="/list-bibliography-delegates/"
data-add-to-bibliography-url="/add-to-bibliography/"
data-get-article-ids-by-search-url="/get-article-ids-by-search/"
data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/">
<input type="hidden" name="csrfmiddlewaretoken" value="ZLeiskFVEsKKhgUNI2Tovk7s9gLtbaN8gyYn5a8he3xebH0DllwqZsD6HktF4Lls">
<div class="action-panel-control-wrap bibliographies-controls">
<div class="choice-group">
<ul class="bibliographies-action-add radio-group-items">
<li>
<input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/>
<label for="my-bibliography">My Bibliography</label>
</li>
</ul>
</div>
</div>
<div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message">
Unable to load your delegates due to an error<br>
<a href="#">Please try again</a>
</div>
<div class="action-panel-actions">
<button class="action-panel-submit"
type="submit"
data-loading-label="Adding..."
data-pinger-ignore>
Add
</button>
<button class="action-panel-cancel"
aria-label="Close 'Add to bibliography' panel"
ref="linksrc=close_bibliography_panel"
aria-controls="bibliography-action-panel"
aria-expanded="false"
data-ga-category="save_share"
data-ga-action="mybib"
data-ga-label="cancel">
Cancel
</button>
</div>
</form>
</div>
</div>
<div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true"
data-saved-search-open-panel-enabled="false"
data-saved-search-open-panel-url-hash="#open-saved-search-panel">
<div class="inner-wrap">
<h2 class="action-panel-heading">
Your saved search
</h2>
<form id="saved-search-action-panel-form"
class="saved-search-action-panel-form action-panel-content action-form"
data-create-saved-search-url="/create-saved-search/"
data-try-search-terms-url="/try-search-term/"
data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/">
<input type="hidden" name="csrfmiddlewaretoken" value="ZLeiskFVEsKKhgUNI2Tovk7s9gLtbaN8gyYn5a8he3xebH0DllwqZsD6HktF4Lls">
<div class="action-panel-control-wrap">
<label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk">
Name of saved search:
</label>
<input maxlength="200"
type="text"
name="saved-search-name"
id="saved-search-name"
class="saved-search-name"
value=""
required
pattern="[^&quot;&amp;=&lt;&gt;\/]*" title="The following characters are not allowed in the Name field: &quot;&amp;=&lt;&gt;/">
</div>
<div class="action-panel-control-wrap">
<label for="saved-search-term" class="action-panel-label required-field-asterisk">
Search terms:
</label>
<textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea>
</div>
<div class="test-search-term-wrap">
<a href="#" class="try-search-term">Test search terms</a>
</div>
<div class="choice-group action-panel-extra-margin-top">
<span class="action-panel-label" id="fieldset-label">
Would you like email updates of new search results?
</span>
<fieldset id="saved-search-alert" aria-describedby="fieldset-label">
<legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend>
<ul class="radio-group-items">
<li>
<input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked>
<label for="saved-search-alert-yes" class="action-panel-label">Yes</label>
</li>
<li>
<input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no">
<label for="saved-search-alert-no" class="action-panel-label">No</label>
</li>
</ul>
</fieldset>
</div>
<div class="alert-schedule-wrap">
<div class="action-panel-control-wrap">
<label class="action-panel-label">
Email:
</label>
<span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span>
</div>
<div class="action-panel-control-wrap action-panel-extra-margin-top">
<label for="saved-search-frequency" class="action-panel-label">
Frequency:
</label>
<select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency">
<option value="monthly">Monthly</option>
<option value="weekly">Weekly</option>
<option value="daily">Daily</option>
</select>
</div>
<div class="action-panel-control-wrap saved-search-monthly-additional">
<label for="saved-search-monthly-on-day" class="action-panel-label">
Which day?
</label>
<select id="saved-search-monthly-on-day" class="no-border-panel-selector">
<option value="Sunday">The first Sunday</option>
<option value="Monday">The first Monday</option>
<option value="Tuesday">The first Tuesday</option>
<option value="Wednesday">The first Wednesday</option>
<option value="Thursday">The first Thursday</option>
<option value="Friday">The first Friday</option>
<option value="Saturday">The first Saturday</option>
<option value="day">The first day</option>
<option value="weekday">The first weekday</option>
</select>
</div>
<div class="action-panel-control-wrap saved-search-weekly-additional">
<label for="saved-search-weekly-on-day" class="action-panel-label">
Which day?
</label>
<select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day">
<option value="Sunday">Sunday</option>
<option value="Monday">Monday</option>
<option value="Tuesday">Tuesday</option>
<option value="Wednesday">Wednesday</option>
<option value="Thursday">Thursday</option>
<option value="Friday">Friday</option>
<option value="Saturday">Saturday</option>
</select>
</div>
<div class="action-panel-control-wrap">
<label for="saved-search-report" class="action-panel-label">
Report format:
</label>
<select id="saved-search-report" class="no-border-panel-selector saved-search-report">
<option value="DocSum">Summary</option>
<option value="DocSumText">Summary (text)</option>
<option value="Abstract">Abstract</option>
<option value="AbstractText">Abstract (text)</option>
<option value="MEDLINE">PubMed</option>
</select>
</div>
<div class="action-panel-control-wrap">
<label for="saved-search-amount" class="action-panel-label">
Send at most:
</label>
<select id="saved-search-amount" class="no-border-panel-selector saved-search-amount">
<option value="1">1 item</option>
<option value="5" selected>5 items</option>
<option value="10">10 items</option>
<option value="20">20 items</option>
<option value="50">50 items</option>
<option value="100">100 items</option>
<option value="200">200 items</option>
</select>
</div>
<div>
<input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result">
<label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox">
Send even when there aren't any new results
</label>
</div>
<div class="action-panel-control-wrap option-text-in-email-wrap">
<label for="saved-search-email-text" class="action-panel-label">
Optional text in email:
</label>
<textarea name="saved-search-email-text"
id="saved-search-email-text"
class="saved-search-email-text"></textarea>
</div>
</div>
<div class="action-panel-actions">
<button class="action-panel-submit"
type="submit"
data-loading-label="Saving..."
data-ga-category="save_share"
data-ga-action="alert"
data-ga-label="save">
Save
</button>
<button class="action-panel-cancel"
aria-label="Close 'Your saved search' panel"
ref="linksrc=close_saved_search_panel"
aria-controls="saved-search-action-panel"
aria-expanded="false"
data-ga-category="save_share"
data-ga-action="alert"
data-ga-label="cancel">
Cancel
</button>
</div>
</form>
</div>
</div>
<div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true">
<div class="inner-wrap">
<h2 class="action-panel-heading">
Create a file for external citation management software
</h2>
<form id="citation-manager-action-panel-form"
class="action-panel-content action-form"
action="/results-export-ids/"
data-by-search-action="/results-export-search-data/"
data-by-ids-action="/results-export-ids/"
method="post"
data-by-search-method="post"
data-by-ids-method="post">
<input type="hidden" name="csrfmiddlewaretoken" value="ZLeiskFVEsKKhgUNI2Tovk7s9gLtbaN8gyYn5a8he3xebH0DllwqZsD6HktF4Lls">
<input name="results-format" type="hidden" value="pubmed"/>
<div class="action-panel-actions">
<button class="action-panel-submit"
type="submit"
data-loading-label="Sending..."
data-ga-category="save_share"
data-ga-action="citation_manager"
data-ga-label="save">
Create file
</button>
<button class="action-panel-cancel"
aria-label="Close 'Send citations to citation manager' panel"
ref="linksrc=close_citation_manager_panel"
aria-controls="citation-manager-action-panel"
aria-expanded="false"
data-ga-category="save_share"
data-ga-action="citation_manager"
data-ga-label="cancel">
Cancel
</button>
</div>
</form>
</div>
</div>
<div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true">
<div class="inner-wrap">
<h2 class="action-panel-heading">
Your RSS Feed
</h2>
<form id="rss-action-panel-form"
class="rss-action-panel-form action-panel-content action-form"
data-create-rss-feed-url="/create-rss-feed-url/"
data-search-form-term-value="">
<input type="hidden" name="csrfmiddlewaretoken" value="ZLeiskFVEsKKhgUNI2Tovk7s9gLtbaN8gyYn5a8he3xebH0DllwqZsD6HktF4Lls">
<div class="action-panel-control-wrap">
<label for="rss-name" class="action-panel-label required-field-asterisk">
Name of RSS Feed:
</label>
<input maxlength="200"
placeholder="Name"
type="text"
name="rss-name"
id="rss-name"
class="rss-name"
value=''
required
pattern="[^&quot;&amp;=&lt;&gt;\/]*" title="The following characters are not allowed in the Name field: &quot;&amp;=&lt;&gt;/">
</div>
<div class="rss-limit-wrap">
<div class="action-panel-control-wrap action-panel-extra-margin-top">
<label for="rss-limit" class="action-panel-label">
Number of items displayed:
</label>
<select id="rss-limit" class="no-border-panel-selector rss-limit">
<option value="5">5</option>
<option value="10">10</option>
<option value="15" selected="selected">15</option>
<option value="20">20</option>
<option value="50">50</option>
<option value="100">100</option>
</select>
</div>
</div>
<div class="action-panel-actions">
<button class="action-panel-submit"
type="submit"
data-loading-label="Creating..."
data-ga-category="save_share"
data-ga-action="alert"
data-ga-label="save">
Create RSS
</button>
<button class="action-panel-cancel"
aria-label="Close 'Your RSS' panel"
ref="linksrc=close_rss_panel"
aria-controls="rss-action-panel"
aria-expanded="false"
data-ga-category="save_share"
data-ga-action="alert"
data-ga-label="cancel">
Cancel
</button>
</div>
<div class="action-panel-control-wrap rss-link-copy-wrap">
<label for="rss-link" class="usa-sr-only">RSS Link</label>
<input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link">
<button
type="button"
disabled
class="rss-link-copy-button disabled"
data-ga-category="save_share"
data-ga-action="rss"
data-ga-label="copy">
Copy
</button>
</div>
</form>
</div>
</div>
</div>
</div>
<div class="article-page" id="article-page" data-article-pmid="31210357">
<aside class="page-sidebar">
<div class="inner-wrap">
<div class="full-text-links">
<div class="full-view">
<h3 class="title">
Full text links
</h3>
<div class="full-text-links-list">
<a class="link-item
dialog-focus"
href="https://doi.org/10.1002/14651858.CD010678.pub3"
target="_blank"
rel="noopener"
ref="linksrc=fulltextorjournal_fulltext&amp;is_pmc=False&amp;PrId=3058&amp;itool=Abstract-def&amp;log$=linkouticon&amp;uid=31210357&amp;db=pubmed&amp;nlmid=100909747"
title="See full text options at Wiley"
data-ga-category="full_text"
data-ga-action="Wiley"
data-ga-label="31210357"
><img src="https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--media.wiley.com-assets-7331-42-Cochrane_Library_Logo_RGB_120x30.jpg" alt="Wiley full text link"><span class="text">
Wiley
</span></a><a class="link-item
pmc
"
href="https://pmc.ncbi.nlm.nih.gov/articles/pmid/31210357/"
target="_blank"
rel="noopener"
ref="linksrc=fulltextorjournal_fulltext&amp;is_pmc=True&amp;PrId=3494&amp;itool=Abstract-def&amp;log$=linkouticon&amp;uid=31210357&amp;db=pubmed&amp;nlmid=100909747"
title="Free full text at PubMed Central"
data-ga-category="full_text"
data-ga-action="PMC"
data-ga-label="31210357"
><span class="text">
Free PMC article
</span></a>
</div>
</div>
<div class="short-view">
<a href="#" class="full-text-links-button full-text-links-dialog-trigger">
Full text links
</a>
</div>
</div>
<div class="actions-buttons sidebar"><h3 class="title">Actions</h3><div class="inner-wrap"><button class="citation-button citation-dialog-trigger"
aria-label="Open dialog with citation text in different styles"
data-ga-category="save_share"
data-ga-action="cite"
data-ga-label="open"
data-all-citations-url="/31210357/citations/"
data-citation-style="nlm"
data-pubmed-format-link="/31210357/export/"><span class="button-label">Cite</span></button><link type="text/css" href="ncbi-overlay-block/src/overlay-block.css"><div class="collections-button-container" data-article-id="31210357" data-article-db="pubmed"><button class="collections-button collections-dialog-trigger"
aria-label="Save article in MyNCBI collections."
data-ga-category="collections_button"
data-ga-action="click"
data-ga-label="collections_button"
data-collections-open-dialog-enabled="false"
data-collections-open-dialog-url="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F31210357%2F%23open-collections-dialog"
data-in-collections="false"><span class="button-label">Collections</span></button><div class="overlay" role="dialog"><div id="collections-action-dialog"
class="dialog collections-dialog"
aria-hidden="true"><div class="title">Add to Collections</div><div class="collections-action-panel action-panel"><form id="collections-action-dialog-form"
class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
data-existing-collections-url="/list-existing-collections/"
data-add-to-existing-collection-url="/add-to-existing-collection/"
data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/"
data-myncbi-max-collection-name-length="100"
data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"><input type="hidden" name="csrfmiddlewaretoken" value="ZLeiskFVEsKKhgUNI2Tovk7s9gLtbaN8gyYn5a8he3xebH0DllwqZsD6HktF4Lls"><div class="choice-group" role="radiogroup"><ul class="radio-group-items"><li><input type="radio"
id="collections-action-dialog-new"
class="collections-new"
name="collections"
value="new"
data-ga-category="collections_button"
data-ga-action="click"
data-ga-label="collections_radio_new"><label for="collections-action-dialog-new">Create a new collection</label></li><li><input type="radio"
id="collections-action-dialog-existing"
class="collections-existing"
name="collections"
value="existing"
checked="true"
data-ga-category="collections_button"
data-ga-action="click"
data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li></ul></div><div class="controls-wrapper"><div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk">
Name your collection:
</label><input
type="text"
name="add-to-new-collection"
id="collections-action-dialog-add-to-new"
class="collections-action-add-to-new"
pattern="[^&quot;&amp;=&lt;&gt;\/]*" title="The following characters are not allowed in the Name field: &quot;&amp;=&lt;&gt;/"
maxlength="100"
data-ga-category="collections_button"
data-ga-action="create_collection"
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In 2011 the World Health Organization (WHO) recommended parenteral artesunate in preference to quinine as first-line treatment for people with severe malaria. Prior to this recommendation many countries, particularly in Africa, had begun to use artemether, an alternative artemisinin derivative. This Cochrane Review evaluates intramuscular artemether compared with both quinine and artesunate.
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Search methods:
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We searched the Cochrane Infectious Diseases Group Specialized Register, CENTRAL (the Cochrane Library), MEDLINE, Embase, and LILACS, ISI Web of Science, conference proceedings, and reference lists of articles. We also searched the WHO International Clinical Trial Registry Platform, ClinicalTrials.gov, and the metaRegister of Controlled Trials (mRCT) for ongoing trials up to 7 September 2018. We checked the reference lists of all studies identified by the search. We examined references listed in review articles and previously compiled bibliographies to look for eligible studies.
</p>
<p>
<strong class="sub-title">
Selection criteria:
</strong>
Randomized controlled trials (RCTs) comparing intramuscular artemether with intravenous/intramuscular quinine or artesunate for treating severe malaria.
</p>
<p>
<strong class="sub-title">
Data collection and analysis:
</strong>
The primary outcome was all-cause death. Two review authors independently screened each article by title and abstract, and examined potentially relevant studies for inclusion using an eligibility form. Two review authors independently extracted data and assessed risk of bias of included studies. We summarized dichotomous outcomes using risk ratios (RRs) and continuous outcomes using mean differences (MDs), and have presented both measures with 95% confidence intervals (CIs). Where appropriate, we combined data in meta-analyses and used the GRADE approach to summarize the certainty of the evidence.
</p>
<p>
<strong class="sub-title">
Main results:
</strong>
We included 19 RCTs, enrolling 2874 adults and children with severe malaria, carried out in Africa (12 trials) and in Asia (7 trials).Artemether versus quinineFor children, there is probably little or no difference in the risk of death between intramuscular artemether and quinine (RR 0.97, 95% CI 0.77 to 1.21; 13 trials, 1659 participants, moderate-certainty evidence). Coma resolution time may be about five hours shorter with artemether (MD -5.45, 95% CI -7.90 to -3.00; six trials, 358 participants, low-certainty evidence). Artemether may make little difference to neurological sequelae (RR 0.84, 95% CI 0.66 to 1.07; seven trials, 968 participants, low-certainty evidence). Compared to quinine, artemether probably shortens the parasite clearance time by about nine hours (MD -9.03, 95% CI -11.43 to -6.63; seven trials, 420 participants, moderate-certainty evidence), and may shorten the fever clearance time by about three hours (MD -3.73, 95% CI -6.55 to -0.92; eight trials, 457 participants, low-certainty evidence).For adults, treatment with intramuscular artemether probably results in fewer deaths than treatment with quinine (RR 0.59, 95% CI 0.42 to 0.83; four trials, 716 participants, moderate-certainty evidence).Artemether versus artesunateArtemether and artesunate have not been directly compared in randomized trials in children.For adults, mortality is probably higher with intramuscular artemether (RR 1.80, 95% CI 1.09 to 2.97; two trials, 494 participants, moderate-certainty evidence).
</p>
<p>
<strong class="sub-title">
Authors&#x27; conclusions:
</strong>
Artemether appears to be more effective than quinine in children and adults. Artemether compared to artesunate has not been extensively studied, but in adults it appears inferior. These findings are consistent with the WHO recommendations that artesunate is the drug of choice, but artemether is acceptable when artesunate is not available.
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<p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">EE has no known conflicts of interest. EEE has no known conflicts of interest. OO has no known conflicts of interest. MM has no known conflicts of interest.</p>
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<div class="figure-caption-contents">Risk of bias summary: review authors' judgements about each risk of bias item for each included trial.</div>
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<div class="figure-caption-contents"><p> Funnel plot of comparison: 1 Artemether versus quinine, outcome: 1.1 Death. </p></div>
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<h2 class="title">
References
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<div id='top-references-list' class="references-lists-container">
<div class="refs-list">
<h4 class="refs-list-title">References to studies included in this review</h4>
<div class="refs-list">
<h5 class="refs-list-title">Adam 2002 {published data only}</h5>
<ol id="top-references-list-2" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Adam I, Idris HM, MohamedAli AA, Aelbasit IA, Elbashir MI. Comparison of intramuscular artemether and intravenous quinine in the treatment of Sudanese children with severe falciparum malaria. East African Medical Journal 2002;79(12):6215.
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<a
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href="/12683344/"
ref="linksrc=references_link&amp;ordinalpos=1"
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<div class="refs-list">
<h5 class="refs-list-title">Aguwa 2010 {published data only}</h5>
<ol id="top-references-list-3" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Aguwa CN, Ukwe CV, Adibe MO. A comparative study of quinine and artemether in the treatment of severe malaria in Nigerian children. Tropical Journal of Pharmaceutical Research 2010;9(1):117.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">BobossiSerengbe 2015 {published data only}</h5>
<ol id="top-references-list-4" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
BobossiSerengbe G, Gody JC, Fioboy R, Elowa JB, Manirakiza A. Comparison of the effectiveness of artemether and quinine for treatment of severe malaria in children, Bangui, Central African Republic. Bulletin de la Societe de Pathologie Exotique (1990) 2015;108(2):10711.
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<a
class="reference-link"
href="/25925807/"
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PubMed
</a>
</li>
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</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Hien 1996 {published data only}</h5>
<ol id="top-references-list-5" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Tran TH, Day NP, Nguyen HP, Nguyen TH, Tran TH, Pham PL, et al. A controlled trial of artemether or quinine in Vietnamese adults with severe falciparum malaria. New England Journal of Medicine 1996;335(2):7683.
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class="reference-link"
href="/8649493/"
ref="linksrc=references_link&amp;ordinalpos=1"
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PubMed
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</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Huda 2003 {published data only}</h5>
<ol id="top-references-list-6" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Huda SN, Shahab T, Ali SM, Afzal K, Khan HM. A comparative clinical trial of artemether and quinine in children with severe malaria. Indian Pediatrics 2003;40(10):93945.
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class="reference-link"
href="/14581730/"
ref="linksrc=references_link&amp;ordinalpos=1"
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PubMed
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</li>
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</li>
</ol>
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<div class="refs-list">
<h5 class="refs-list-title">Karbwang 1992 {published data only}</h5>
<ol id="top-references-list-7" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Karbwang J, Sukontason K, Rimchala W, Namsiripongpun W, Tin T, Auprayoon P, et al. Preliminary report: a comparative clinical trial of artemether and quinine in severe falciparum malaria. Southeast Asian Journal of Tropical Medicine and Public Health 1992;23(4):76872.
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<a
class="reference-link"
href="/1298087/"
ref="linksrc=references_link&amp;ordinalpos=1"
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PubMed
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</li>
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</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Karbwang 1995 {published data only}</h5>
<ol id="top-references-list-8" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Karbwang J, Tin T, Rimchala W, Sukontason K, Namsiripongpun V, Thanavibul A, et al. Comparison of artemether and quinine in the treatment of severe falciparum malaria in southeast Thailand. Transactions of the Royal Society of Tropical Medicine and Hygiene 1995;89(6):66871.
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<a
class="reference-link"
href="/8594692/"
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</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Minta 2005 {published data only}</h5>
<ol id="top-references-list-9" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Minta D, Sissoko M, Sidibe I, Dolo A, Poudiougou B, Dembele M, et al. Efficacy and safety of artemether in the treatment of severe and complicated malaria in Mali [Efficacite et tolerance de l'artemether dans le traitement du paludisme grave et complique au Mali]. Mali Médical 2005;20(12):2832.
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<a
class="reference-link"
href="/19617028/"
ref="linksrc=references_link&amp;ordinalpos=1"
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PubMed
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</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Murphy 1996 {published data only}</h5>
<ol id="top-references-list-10" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Murphy S, English M, Waruiru C, Mwangi I, Amukoye E, Crawley J, et al. An open randomized trial of artemether versus quinine in the treatment of cerebral malaria in African children. Transactions of the Royal Society of Tropical Medicine and Hygiene 1996;90(3):298301.
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<a
class="reference-link"
href="/8758084/"
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PubMed
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</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Ojuawo 1998 {published data only}</h5>
<ol id="top-references-list-11" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Ojuawo A, Adegboye AR, Oyewalo O. Clinical response and parasite clearance in childhood cerebral malaria: A comparison between intramuscular artemether and intravenous quinine. East African Medical Journal 1998;75:4502.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Olumese 1999 {published data only}</h5>
<ol id="top-references-list-12" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Olumese PE, Björkman A, Gbadegesin RA, Adeyemo AA, Walker O. Comparative efficacy of intramuscular artemether and intravenous quinine in Nigerian children with cerebral malaria. Acta Tropica 1999;73(3):2316.
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<a
class="reference-link"
href="/10546840/"
ref="linksrc=references_link&amp;ordinalpos=1"
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PubMed
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</li>
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</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Osonuga 2009 {published data only}</h5>
<ol id="top-references-list-13" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Osonuga O, Osonuga AA, Osonuga IO, Osonuga A. Temperature changes in the course of treatment of severe malaria patients with artemether and quinine. Asian Journal of Medical Sciences 2011;2(1):415.
</li>
</ol>
</li>
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Osonuga OA, Osonuga AA, Osonuga IO, Osonuga A. Comparison of Coma Resolution Time in the Course of Treating Childrenwith Severe Falciparum Malaria with Quinine and Artemether. World Journal of Medical Sciences 2011;6(2):425.
</li>
</ol>
</li>
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Osonuga OA, Osonuga IO. Parasitaemia changes in the course of treatment of severe malaria patients with artemether and quinine (A preliminary study). Macedonian Journal of Medical Sciences 2009;2(4):31923.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Phu 2010 {published data only}</h5>
<ol id="top-references-list-14" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Phu NH, Tuan PQ, Day N, Mai NT, Chau TT, Chuong LV, et al. Randomized controlled trial of artesunate or artemether in Vietnamese adults with severe falciparum malaria. Malaria Journal 2010;9:97.
-
<a
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PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Satti 2002 {published data only}</h5>
<ol id="top-references-list-15" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Satti GM, Elhassan SH, Ibrahim SA. The efficacy of artemether versus quinine in the treatment of cerebral malaria. Journal of the Egyptian Society of Parasitology 2002;32(2):61123.
-
<a
class="reference-link"
href="/12214938/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="12214938"
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PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Seaton 1998 {published data only}</h5>
<ol id="top-references-list-16" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Seaton RA, Trevett AJ, Wembri JP, Nwokolo N, Naraqi S, Black J, et al. Randomized comparison of intramuscular artemether and intravenous quinine in adult, Melanesian patients with severe or complicated, Plasmodium falciparum malaria in Papua New Guinea. Annals of Tropical Medicine and Parasitology 1998;92(2):1339.
-
<a
class="reference-link"
href="/9625908/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="9625908"
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PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Taylor 1998 {published data only}</h5>
<ol id="top-references-list-17" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Taylor TE, Wills BA, Courval JM, Molyneux ME. Intramuscular artemether vs intravenous quinine: an open, randomized trial in Malawian children with cerebral malaria. Tropical Medicine and International Health 1998;3(1):38.
-
<a
class="reference-link"
href="/9484961/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="9484961"
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PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">van Hensbroek 1996 {published data only}</h5>
<ol id="top-references-list-18" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Hensbroek MB, Onyiorah E, Jaffar S, Schneider G, Palmer A, Frenkel J, et al. A trial of artemether or quinine in children with cerebral malaria. New England Journal of Medicine 1996;335(2):6975.
-
<a
class="reference-link"
href="/8649492/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="8649492"
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PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Vinh 1997 {published data only}</h5>
<ol id="top-references-list-19" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Ha V, Nguyen NH, Tran TB, Bui MC, Nguyen HP, Tran TH, et al. Severe and complicated malaria treated with artemisinin, artesunate or artemether in Viet Nam. Transactions of the Royal Society of Tropical Medicine and Hygiene 1997;91(4):4657.
-
<a
class="reference-link"
href="/9373657/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="9373657"
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PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Walker 1993 {published data only}</h5>
<ol id="top-references-list-20" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Walker O, Salako LA, Omukhodion SI, Sowunmi A. An open randomized comparative study of intramuscular artemether and intravenous quinine in cerebral malaria in children. Transactions of the Royal Society of Tropical Medicine and Hygiene 1993;87(5):5646.
-
<a
class="reference-link"
href="/8266412/"
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PubMed
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</li>
</ol>
</li>
</ol>
</div>
</div>
<div class="refs-list">
<h4 class="refs-list-title">References to studies excluded from this review</h4>
<div class="refs-list">
<h5 class="refs-list-title">Aceng 2005 {published data only}</h5>
<ol id="top-references-list-22" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Aceng JR, Byarugaba JS, Tumwine JK. Rectal artemether versus intravenous quinine for the treatment of cerebral malaria in children in Uganda: randomised clinical trial. British Medical Journal 2005;330(7487):334.
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC548725/"
ref="linksrc=references_link&amp;ordinalpos=1"
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PMC
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data-ga-category="reference"
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PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Bhattacharya 1997 {published data only}</h5>
<ol id="top-references-list-23" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Bhattacharya PC, Paidhungat AJ, Patel K. Artemether in moderate to severe malaria: a multicenter trial in India. Southeast Asian Journal of Tropical Medicine and Public Health 1997;28(4):73640.
-
<a
class="reference-link"
href="/9656395/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="9656395"
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PubMed
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</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Bunnag 1992 {published data only}</h5>
<ol id="top-references-list-24" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Bunnag D, Karbwang J, Harinasuta T. Artemether in the treatment of multiple drug resistant falciparum malaria. Southeast Asian Journal of Tropical Medicine and Public Health 1992;23(4):7627.
-
<a
class="reference-link"
href="/1298086/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="1298086"
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PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Dunyo 2011 {published data only}</h5>
<ol id="top-references-list-25" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Dunyo S, Sirugo G, Sesay S, Bisseye C, Njie F, Adiamoh M, et al. Randomized trial of safety and effectiveness of chlorproguanildapsone and lumefantrineartemether for uncomplicated malaria in children in the Gambia. PLoS One 2011;6(6):e17371.
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC3110183/"
ref="linksrc=references_link&amp;ordinalpos=1"
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PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Falade 2007 {published data only}</h5>
<ol id="top-references-list-26" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Falade CO, Fadero FF, Happi CT, DadaAdegbola HO, Gbotosho GO, Ayede I, et al. Dihydroartemisinin suppository in moderately severe malaria: comparative efficacy of dihydroartemisinin suppository versus intramuscular artemether followed by oral sulfadoxinepyrimethamine in the management of moderately severe malaria in Nigerian children. American Journal of Tropical Medicine and Hygiene 2007;76(1):16.
-
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href="/17255220/"
ref="linksrc=references_link&amp;ordinalpos=1"
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</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Fargier 1999 {published data only}</h5>
<ol id="top-references-list-27" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Fargier JJ, Louis FJ, Duparc S, Hounsinou C, Ringwald P, Danis M. Comparative study of artemether and quinine in severe Plasmodium falciparum malaria in adults and older children in Cameroon. Médicine Tropicale 1999;59(2):1516.
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<h5 class="refs-list-title">Reham 2012 {published data only}</h5>
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<h5 class="refs-list-title">Shwe 1988 {published data only}</h5>
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<h4 class="refs-list-title">References to studies awaiting assessment</h4>
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<h5 class="refs-list-title">Danis 1996 {published data only}</h5>
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<h5 class="refs-list-title">Guyatt 2008</h5>
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<h5 class="refs-list-title">Hien 2004</h5>
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<h5 class="refs-list-title">Esu 2013</h5>
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<div id="substances" class="substances keywords-section">
<h2 class="title">
Substances
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