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<meta name="description" content="Based on high-quality evidence this review confirms that paracetamol provides only minimal improvements in pain and function for people with hip or knee osteoarthritis, with no increased risk of adverse events overall. Subgroup analysis indicates that the effects on pain and function do not differ a …"><meta name="keywords" content="pmid:30801133, PMC6388567, doi:10.1002/14651858.CD013273, Meta-Analysis, Systematic Review, Amanda O Leopoldino, Gustavo C Machado, Manuela L Ferreira, Acetaminophen / administration & dosage, Acetaminophen / adverse effects, Acetaminophen / therapeutic use*, Aged, Analgesics, Non-Narcotic / administration & dosage, Analgesics, Non-Narcotic / adverse effects, Analgesics, Non-Narcotic / therapeutic use*, Arthralgia / drug therapy*, Arthralgia / etiology, Humans, Liver / drug effects, Middle Aged, Osteoarthritis, Hip / drug therapy*, Osteoarthritis, Knee / drug therapy*, Pain Measurement, Randomized Controlled Trials as Topic, PubMed Abstract, NIH, NLM, NCBI, National Institutes of Health, National Center for Biotechnology Information, National Library of Medicine, MEDLINE"><meta name="robots" content="index,nofollow,noarchive"><meta property="og:title" content="Paracetamol versus placebo for knee and hip osteoarthritis - PubMed"><meta property="og:url" content="https://pubmed.ncbi.nlm.nih.gov/30801133/"><meta property="og:description" content="Based on high-quality evidence this review confirms that paracetamol provides only minimal improvements in pain and function for people with hip or knee osteoarthritis, with no increased risk of adverse events overall. Subgroup analysis indicates that the effects on pain and function do not differ a …"><meta property="og:image" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg"><meta property="og:image:secure_url" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg"><meta property="og:type" content="website"><meta property="og:site_name" content="PubMed"><meta name="twitter:domain" content="pubmed.ncbi.nlm.nih.gov"><meta name="twitter:card" content="summary_large_image"><meta name="twitter:title" content="Paracetamol versus placebo for knee and hip osteoarthritis - PubMed"><meta name="twitter:url" content="https://pubmed.ncbi.nlm.nih.gov/30801133/"><meta name="twitter:description" content="Based on high-quality evidence this review confirms that paracetamol provides only minimal improvements in pain and function for people with hip or knee osteoarthritis, with no increased risk of adverse events overall. Subgroup analysis indicates that the effects on pain and function do not differ a …"><meta name="twitter:image" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg">
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data-ga-action="user_guide">
|
||
User Guide
|
||
</a>
|
||
</span>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
</form>
|
||
|
||
|
||
<div id="article-page-header">
|
||
<div id="article-top-actions-bar" class="article-top-actions-bar">
|
||
<div class="inner-wrap">
|
||
<div class="actions-container">
|
||
<div class="return-to-search">
|
||
|
||
|
||
</div>
|
||
|
||
<div class="multiple-results-actions " role="region" aria-label="save, email, send to">
|
||
<button id="save-results-panel-trigger"
|
||
type="button"
|
||
class="save-results save-results-panel-trigger"
|
||
aria-expanded="false"
|
||
aria-controls="save-action-panel"
|
||
data-ga-category="save_share"
|
||
data-ga-action="save"
|
||
data-ga-label="open">
|
||
Save
|
||
</button><button id="email-results-panel-trigger"
|
||
type="button"
|
||
class="email-results email-results-panel-trigger"
|
||
aria-expanded="false"
|
||
aria-controls="email-action-panel"
|
||
data-ga-category="save_share"
|
||
data-ga-action="email"
|
||
data-ga-label="open">
|
||
Email
|
||
</button><div class="more-actions dropdown-block"><button id="more-actions-trigger"
|
||
type="button"
|
||
class="trigger more-actions-trigger"
|
||
ref="linksrc=show_moreactions_btn"
|
||
aria-label="Send to"
|
||
aria-controls="more-actions-dropdown">Send to</button><div id="more-actions-dropdown" class="dropdown dropdown-container" hidden><div class="content"><ul class="more-actions-links"><li><a class="clipboard-panel-trigger dropdown-block-link "
|
||
href="#"
|
||
role="button"
|
||
data-ga-category="save_share"
|
||
data-ga-action="clipboard"
|
||
data-ga-label="send">
|
||
Clipboard
|
||
</a></li><li><a role="button" class="dropdown-block-link bibliography-trigger-target" href="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F30801133%2F%23open-bibliography-panel">My Bibliography</a></li><li><a role="button" class="dropdown-block-link collections-trigger-target" href="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F30801133%2F%23open-collections-panel">Collections</a></li><li><a role="button" class="citation-manager-panel-trigger dropdown-block-link citation-manager-trigger-target" href="#">Citation manager</a></li></ul></div></div></div>
|
||
</div>
|
||
|
||
|
||
|
||
<div class="display-options" data-format-key="format"
|
||
data-default-format-value="abstract"
|
||
data-current-format-value="abstract" role="region">
|
||
<button
|
||
class="trigger usa-button"
|
||
title="Change format"
|
||
data-ga-category="display_options"
|
||
data-ga-action="display_options_dialog">
|
||
<span class="button-label">Display options</span>
|
||
</button>
|
||
|
||
<div class="dropdown" hidden>
|
||
<div class="title">
|
||
Display options
|
||
</div>
|
||
|
||
<div class="content">
|
||
|
||
<div class="format-container">
|
||
<span class="option-label">
|
||
Format
|
||
</span>
|
||
<select name="format" data-initial-value="abstract" aria-label="Display format" id="article-display-format">
|
||
<option value="abstract">Abstract</option>
|
||
|
||
<option value="pubmed">PubMed</option>
|
||
|
||
<option value="pmid">PMID</option>
|
||
|
||
</select>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="DqW5iuhCWCemqhY893KAfqzkOPEmjdo7UdGaVkKYwd1QkI4YMmnCJy5YmTmycOWr">
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="article-panels-container" class="article-panels-container">
|
||
<div id="save-action-panel" class="save-action-panel action-panel" aria-hidden="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Save citation to file
|
||
</h2>
|
||
<form id="save-action-panel-form"
|
||
class="action-panel-content action-form"
|
||
action="/results-export-ids/"
|
||
data-by-search-action="/results-export-search-data/"
|
||
data-by-ids-action="/results-export-ids/"
|
||
method="post"
|
||
data-by-search-method="post"
|
||
data-by-ids-method="post">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="DqW5iuhCWCemqhY893KAfqzkOPEmjdo7UdGaVkKYwd1QkI4YMmnCJy5YmTmycOWr">
|
||
|
||
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="save-action-format" class="action-panel-label">
|
||
Format:
|
||
</label>
|
||
<select id="save-action-format" name="results-format" class="action-panel-selector">
|
||
<option value="summary-text">Summary (text)</option>
|
||
<option value="pubmed-text">PubMed</option>
|
||
<option value="pmid">PMID</option>
|
||
<option value="abstract">Abstract (text)</option>
|
||
<option value="csv">CSV</option>
|
||
</select>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Saving..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="save"
|
||
data-ga-label="save">
|
||
Create file
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Save citations to file' panel"
|
||
ref="linksrc=close_save_panel"
|
||
aria-controls="save-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="save"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div id="email-action-panel"
|
||
class="email-action-panel action-panel"
|
||
aria-hidden="true"
|
||
data-recaptcha-script-url="https://www.recaptcha.net/recaptcha/enterprise.js?render=explicit&onload=onloadCaptchaCallback"
|
||
data-recaptcha-enabled="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Email citation
|
||
</h2>
|
||
<form id="email-action-panel-form"
|
||
class="action-panel-content action-form"
|
||
action="/send-email/"
|
||
data-by-search-action="/results-export-email-by-search-data/"
|
||
data-by-ids-action="/send-email/"
|
||
data-by-search-method="post"
|
||
data-by-ids-method="post"
|
||
method="post"
|
||
>
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="DqW5iuhCWCemqhY893KAfqzkOPEmjdo7UdGaVkKYwd1QkI4YMmnCJy5YmTmycOWr">
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<span class="action-panel-label">
|
||
Subject:
|
||
</span>
|
||
<span class="email-subject" id="email-subject" aria-label="Email subject">1 selected item: 30801133 - PubMed</span>
|
||
<input type="hidden" name="email-subject" value="1 selected item: 30801133"/>
|
||
<input type="hidden" name="email-subject-hash" value="d86db4cce3f4affbb58c53fe71504292a492f581e553971f113dc456d0c8da7c"/>
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="email-to" class="action-panel-label required-field-asterisk">
|
||
To:
|
||
</label>
|
||
<input type="email" aria-label="Recipient Email Address" placeholder="email@example.com" id="email-to" class="email-to" pattern="^[a-zA-Z0-9_.+-]+@[a-zA-Z0-9-]+\.[a-zA-Z0-9-.]+$" maxlength="100" required>
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="email-from" class="action-panel-label">
|
||
From:
|
||
</label>
|
||
<input type="email" aria-label="Sender Email Address" placeholder="email@example.com" id="email-from" class="email-from" pattern="^[a-zA-Z0-9_.+-]+@[a-zA-Z0-9-]+\.[a-zA-Z0-9-.]+$" maxlength="256">
|
||
</div>
|
||
|
||
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="email-citation-format" class="action-panel-label">
|
||
Format:
|
||
</label>
|
||
<select id="email-citation-format" name="citation-format" class="action-panel-selector email-citation-format">
|
||
<option selected="selected" value="summary">Summary</option>
|
||
<option value="summary-text">Summary (text)</option>
|
||
<option value="abstract">Abstract</option>
|
||
<option value="abstract-text">Abstract (text)</option>
|
||
|
||
</select>
|
||
</div>
|
||
<div class="include-supplemental-container">
|
||
<input type="checkbox" aria-label="Include MeSH and other data" name="include-supplemental" id="email-include-supplemental" class="email-include-supplemental">
|
||
<label for="email-include-supplemental" class="email-include-supplemental-label">MeSH and other data</label>
|
||
</div>
|
||
|
||
|
||
|
||
<div class="form-field recaptcha ">
|
||
|
||
|
||
|
||
<div class="g-recaptcha" id="id-recaptcha" data-sitekey="6LfsWHMdAAAAAClKbtOpjQ2pMjgsGxvv7NdZW9uI"></div>
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
<div id="captcha-error-message" class="usa-input-error-message captcha-validation-message" role="alert"></div>
|
||
|
||
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Sending..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="email"
|
||
data-ga-label="send">
|
||
Send email
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Email citations' panel"
|
||
ref="linksrc=close_email_panel"
|
||
aria-controls="email-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="email"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
<input type="hidden" name="email-search-details" value="" />
|
||
<input type="hidden" name="email-search-details-hash" value="0e42663a6c3bd85498fcb88798998fed7bfdc45d457db35281e41afe13cc0524" />
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="collections-action-panel"
|
||
class="collections-action-panel action-panel in-progress-dots-panel"
|
||
aria-hidden="true"
|
||
data-collections-open-panel-enabled="false"
|
||
data-collections-open-panel-url-hash="#open-collections-panel">
|
||
<div class="inner-wrap">
|
||
<h3 class="action-panel-heading">
|
||
Add to Collections
|
||
</h3>
|
||
|
||
|
||
<form id="collections-action-panel-form"
|
||
class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
|
||
data-existing-collections-url="/list-existing-collections/"
|
||
data-add-to-existing-collection-url="/add-to-existing-collection/"
|
||
data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/"
|
||
data-get-article-ids-by-search-url="/get-article-ids-by-search/"
|
||
data-myncbi-max-collection-name-length="100"
|
||
data-add-to-collection-max-amount="1000"
|
||
data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="DqW5iuhCWCemqhY893KAfqzkOPEmjdo7UdGaVkKYwd1QkI4YMmnCJy5YmTmycOWr">
|
||
|
||
|
||
|
||
<div class="choice-group" role="radiogroup">
|
||
<ul class="radio-group-items">
|
||
<li>
|
||
<input type="radio"
|
||
id="collections-action-panel-new"
|
||
class="collections-new"
|
||
name="collections"
|
||
value="new"
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="collections_radio_new">
|
||
<label for="collections-action-panel-new">Create a new collection</label>
|
||
</li>
|
||
<li>
|
||
<input type="radio"
|
||
id="collections-action-panel-existing"
|
||
class="collections-existing"
|
||
name="collections"
|
||
value="existing"
|
||
checked="true"
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="collections_radio_existing">
|
||
<label for="collections-action-panel-existing">Add to an existing collection</label>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
|
||
<div class="controls-wrapper">
|
||
<div class="action-panel-control-wrap new-collections-controls">
|
||
<label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk">
|
||
Name your collection:
|
||
</label>
|
||
<input
|
||
type="text"
|
||
name="add-to-new-collection"
|
||
id="collections-action-panel-add-to-new"
|
||
class="collections-action-add-to-new"
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"
|
||
maxlength="100"
|
||
data-ga-category="save_share"
|
||
data-ga-action="create_collection"
|
||
data-ga-label="non_favorties_collection">
|
||
<div class="collections-new-name-too-long usa-input-error-message selection-validation-message">
|
||
Name must be less than 100 characters
|
||
</div>
|
||
</div>
|
||
<div class="action-panel-control-wrap existing-collections-controls">
|
||
<label for="collections-action-panel-add-to-existing" class="action-panel-label">
|
||
Choose a collection:
|
||
</label>
|
||
<select id="collections-action-panel-add-to-existing"
|
||
class="action-panel-selector collections-action-add-to-existing"
|
||
data-ga-category="save_share"
|
||
data-ga-action="select_collection"
|
||
data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'">
|
||
</select>
|
||
<div class="collections-retry-load-on-error usa-input-error-message selection-validation-message">
|
||
Unable to load your collection due to an error<br>
|
||
<a href="#">Please try again</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Adding..."
|
||
data-pinger-ignore
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="add">
|
||
Add
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Add to Collections' panel"
|
||
ref="linksrc=close_collections_panel"
|
||
aria-controls="collections-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="bibliography-action-panel"
|
||
class="bibliography-action-panel action-panel in-progress-dots-panel"
|
||
aria-hidden="true"
|
||
data-bibliography-open-panel-enabled="false"
|
||
data-bibliography-open-panel-url-hash="#open-bibliography-panel">
|
||
<div class="inner-wrap">
|
||
<h3 class="action-panel-heading">
|
||
Add to My Bibliography
|
||
</h3>
|
||
<form id="bibliography-action-panel-form"
|
||
class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
|
||
data-add-to-bibliography-max-amount="100"
|
||
data-add-to-bibliography-batch-size="10"
|
||
data-bibliography-delegates-url="/list-bibliography-delegates/"
|
||
data-add-to-bibliography-url="/add-to-bibliography/"
|
||
data-get-article-ids-by-search-url="/get-article-ids-by-search/"
|
||
data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="DqW5iuhCWCemqhY893KAfqzkOPEmjdo7UdGaVkKYwd1QkI4YMmnCJy5YmTmycOWr">
|
||
|
||
|
||
|
||
<div class="action-panel-control-wrap bibliographies-controls">
|
||
<div class="choice-group">
|
||
<ul class="bibliographies-action-add radio-group-items">
|
||
<li>
|
||
<input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/>
|
||
<label for="my-bibliography">My Bibliography</label>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message">
|
||
Unable to load your delegates due to an error<br>
|
||
<a href="#">Please try again</a>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Adding..."
|
||
data-pinger-ignore>
|
||
Add
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Add to bibliography' panel"
|
||
ref="linksrc=close_bibliography_panel"
|
||
aria-controls="bibliography-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="mybib"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true"
|
||
data-saved-search-open-panel-enabled="false"
|
||
data-saved-search-open-panel-url-hash="#open-saved-search-panel">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Your saved search
|
||
</h2>
|
||
|
||
<form id="saved-search-action-panel-form"
|
||
class="saved-search-action-panel-form action-panel-content action-form"
|
||
data-create-saved-search-url="/create-saved-search/"
|
||
data-try-search-terms-url="/try-search-term/"
|
||
data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="DqW5iuhCWCemqhY893KAfqzkOPEmjdo7UdGaVkKYwd1QkI4YMmnCJy5YmTmycOWr">
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk">
|
||
Name of saved search:
|
||
</label>
|
||
<input maxlength="200"
|
||
type="text"
|
||
name="saved-search-name"
|
||
id="saved-search-name"
|
||
class="saved-search-name"
|
||
value=""
|
||
required
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/">
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-term" class="action-panel-label required-field-asterisk">
|
||
Search terms:
|
||
</label>
|
||
<textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea>
|
||
</div>
|
||
<div class="test-search-term-wrap">
|
||
<a href="#" class="try-search-term">Test search terms</a>
|
||
</div>
|
||
<div class="choice-group action-panel-extra-margin-top">
|
||
<span class="action-panel-label" id="fieldset-label">
|
||
Would you like email updates of new search results?
|
||
</span>
|
||
<fieldset id="saved-search-alert" aria-describedby="fieldset-label">
|
||
<legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend>
|
||
<ul class="radio-group-items">
|
||
<li>
|
||
<input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked>
|
||
<label for="saved-search-alert-yes" class="action-panel-label">Yes</label>
|
||
</li>
|
||
<li>
|
||
<input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no">
|
||
<label for="saved-search-alert-no" class="action-panel-label">No</label>
|
||
</li>
|
||
</ul>
|
||
</fieldset>
|
||
</div>
|
||
|
||
<div class="alert-schedule-wrap">
|
||
<div class="action-panel-control-wrap">
|
||
<label class="action-panel-label">
|
||
Email:
|
||
</label>
|
||
<span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span>
|
||
</div>
|
||
<div class="action-panel-control-wrap action-panel-extra-margin-top">
|
||
<label for="saved-search-frequency" class="action-panel-label">
|
||
Frequency:
|
||
</label>
|
||
<select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency">
|
||
<option value="monthly">Monthly</option>
|
||
<option value="weekly">Weekly</option>
|
||
<option value="daily">Daily</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap saved-search-monthly-additional">
|
||
<label for="saved-search-monthly-on-day" class="action-panel-label">
|
||
Which day?
|
||
</label>
|
||
<select id="saved-search-monthly-on-day" class="no-border-panel-selector">
|
||
<option value="Sunday">The first Sunday</option>
|
||
<option value="Monday">The first Monday</option>
|
||
<option value="Tuesday">The first Tuesday</option>
|
||
<option value="Wednesday">The first Wednesday</option>
|
||
<option value="Thursday">The first Thursday</option>
|
||
<option value="Friday">The first Friday</option>
|
||
<option value="Saturday">The first Saturday</option>
|
||
<option value="day">The first day</option>
|
||
<option value="weekday">The first weekday</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap saved-search-weekly-additional">
|
||
<label for="saved-search-weekly-on-day" class="action-panel-label">
|
||
Which day?
|
||
</label>
|
||
<select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day">
|
||
<option value="Sunday">Sunday</option>
|
||
<option value="Monday">Monday</option>
|
||
<option value="Tuesday">Tuesday</option>
|
||
<option value="Wednesday">Wednesday</option>
|
||
<option value="Thursday">Thursday</option>
|
||
<option value="Friday">Friday</option>
|
||
<option value="Saturday">Saturday</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-report" class="action-panel-label">
|
||
Report format:
|
||
</label>
|
||
<select id="saved-search-report" class="no-border-panel-selector saved-search-report">
|
||
<option value="DocSum">Summary</option>
|
||
<option value="DocSumText">Summary (text)</option>
|
||
<option value="Abstract">Abstract</option>
|
||
<option value="AbstractText">Abstract (text)</option>
|
||
<option value="MEDLINE">PubMed</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-amount" class="action-panel-label">
|
||
Send at most:
|
||
</label>
|
||
<select id="saved-search-amount" class="no-border-panel-selector saved-search-amount">
|
||
<option value="1">1 item</option>
|
||
<option value="5" selected>5 items</option>
|
||
<option value="10">10 items</option>
|
||
<option value="20">20 items</option>
|
||
<option value="50">50 items</option>
|
||
<option value="100">100 items</option>
|
||
<option value="200">200 items</option>
|
||
</select>
|
||
</div>
|
||
<div>
|
||
<input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result">
|
||
<label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox">
|
||
Send even when there aren't any new results
|
||
</label>
|
||
</div>
|
||
<div class="action-panel-control-wrap option-text-in-email-wrap">
|
||
<label for="saved-search-email-text" class="action-panel-label">
|
||
Optional text in email:
|
||
</label>
|
||
<textarea name="saved-search-email-text"
|
||
id="saved-search-email-text"
|
||
class="saved-search-email-text"></textarea>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Saving..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="save">
|
||
Save
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Your saved search' panel"
|
||
ref="linksrc=close_saved_search_panel"
|
||
aria-controls="saved-search-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Create a file for external citation management software
|
||
</h2>
|
||
<form id="citation-manager-action-panel-form"
|
||
class="action-panel-content action-form"
|
||
action="/results-export-ids/"
|
||
data-by-search-action="/results-export-search-data/"
|
||
data-by-ids-action="/results-export-ids/"
|
||
method="post"
|
||
data-by-search-method="post"
|
||
data-by-ids-method="post">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="DqW5iuhCWCemqhY893KAfqzkOPEmjdo7UdGaVkKYwd1QkI4YMmnCJy5YmTmycOWr">
|
||
|
||
|
||
|
||
<input name="results-format" type="hidden" value="pubmed"/>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Sending..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="citation_manager"
|
||
data-ga-label="save">
|
||
Create file
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Send citations to citation manager' panel"
|
||
ref="linksrc=close_citation_manager_panel"
|
||
aria-controls="citation-manager-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="citation_manager"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Your RSS Feed
|
||
</h2>
|
||
|
||
<form id="rss-action-panel-form"
|
||
class="rss-action-panel-form action-panel-content action-form"
|
||
data-create-rss-feed-url="/create-rss-feed-url/"
|
||
data-search-form-term-value="">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="DqW5iuhCWCemqhY893KAfqzkOPEmjdo7UdGaVkKYwd1QkI4YMmnCJy5YmTmycOWr">
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="rss-name" class="action-panel-label required-field-asterisk">
|
||
Name of RSS Feed:
|
||
</label>
|
||
<input maxlength="200"
|
||
placeholder="Name"
|
||
type="text"
|
||
name="rss-name"
|
||
id="rss-name"
|
||
class="rss-name"
|
||
value=''
|
||
required
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/">
|
||
</div>
|
||
|
||
<div class="rss-limit-wrap">
|
||
<div class="action-panel-control-wrap action-panel-extra-margin-top">
|
||
<label for="rss-limit" class="action-panel-label">
|
||
Number of items displayed:
|
||
</label>
|
||
<select id="rss-limit" class="no-border-panel-selector rss-limit">
|
||
<option value="5">5</option>
|
||
<option value="10">10</option>
|
||
<option value="15" selected="selected">15</option>
|
||
<option value="20">20</option>
|
||
<option value="50">50</option>
|
||
<option value="100">100</option>
|
||
</select>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Creating..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="save">
|
||
Create RSS
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Your RSS' panel"
|
||
ref="linksrc=close_rss_panel"
|
||
aria-controls="rss-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap rss-link-copy-wrap">
|
||
<label for="rss-link" class="usa-sr-only">RSS Link</label>
|
||
<input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link">
|
||
<button
|
||
type="button"
|
||
disabled
|
||
class="rss-link-copy-button disabled"
|
||
data-ga-category="save_share"
|
||
data-ga-action="rss"
|
||
data-ga-label="copy">
|
||
Copy
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="article-page" id="article-page" data-article-pmid="30801133">
|
||
<aside class="page-sidebar">
|
||
<div class="inner-wrap">
|
||
|
||
<div class="full-text-links">
|
||
<div class="full-view">
|
||
<h3 class="title">
|
||
Full text links
|
||
</h3>
|
||
<div class="full-text-links-list">
|
||
<a class="link-item
|
||
|
||
dialog-focus"
|
||
href="https://doi.org/10.1002/14651858.CD013273"
|
||
target="_blank"
|
||
rel="noopener"
|
||
|
||
ref="linksrc=fulltextorjournal_fulltext&is_pmc=False&PrId=3058&itool=Abstract-def&log$=linkouticon&uid=30801133&db=pubmed&nlmid=100909747"
|
||
title="See full text options at Wiley"
|
||
|
||
data-ga-category="full_text"
|
||
data-ga-action="Wiley"
|
||
data-ga-label="30801133"
|
||
><img src="https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--media.wiley.com-assets-7331-42-Cochrane_Library_Logo_RGB_120x30.jpg" alt="Wiley full text link"><span class="text">
|
||
|
||
Wiley
|
||
|
||
</span></a><a class="link-item
|
||
pmc
|
||
"
|
||
href="https://pmc.ncbi.nlm.nih.gov/articles/pmid/30801133/"
|
||
target="_blank"
|
||
rel="noopener"
|
||
|
||
ref="linksrc=fulltextorjournal_fulltext&is_pmc=True&PrId=3494&itool=Abstract-def&log$=linkouticon&uid=30801133&db=pubmed&nlmid=100909747"
|
||
title="Free full text at PubMed Central"
|
||
|
||
data-ga-category="full_text"
|
||
data-ga-action="PMC"
|
||
data-ga-label="30801133"
|
||
><span class="text">
|
||
|
||
Free PMC article
|
||
|
||
</span></a>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="short-view">
|
||
<a href="#" class="full-text-links-button full-text-links-dialog-trigger">
|
||
Full text links
|
||
</a>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div class="actions-buttons sidebar"><h3 class="title">Actions</h3><div class="inner-wrap"><button class="citation-button citation-dialog-trigger"
|
||
aria-label="Open dialog with citation text in different styles"
|
||
data-ga-category="save_share"
|
||
data-ga-action="cite"
|
||
data-ga-label="open"
|
||
data-all-citations-url="/30801133/citations/"
|
||
data-citation-style="nlm"
|
||
data-pubmed-format-link="/30801133/export/"><span class="button-label">Cite</span></button><link type="text/css" href="ncbi-overlay-block/src/overlay-block.css"><div class="collections-button-container" data-article-id="30801133" data-article-db="pubmed"><button class="collections-button collections-dialog-trigger"
|
||
aria-label="Save article in MyNCBI collections."
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="collections_button"
|
||
data-collections-open-dialog-enabled="false"
|
||
data-collections-open-dialog-url="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F30801133%2F%23open-collections-dialog"
|
||
data-in-collections="false"><span class="button-label">Collections</span></button><div class="overlay" role="dialog"><div id="collections-action-dialog"
|
||
class="dialog collections-dialog"
|
||
aria-hidden="true"><div class="title">Add to Collections</div><div class="collections-action-panel action-panel"><form id="collections-action-dialog-form"
|
||
class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
|
||
data-existing-collections-url="/list-existing-collections/"
|
||
data-add-to-existing-collection-url="/add-to-existing-collection/"
|
||
data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/"
|
||
data-myncbi-max-collection-name-length="100"
|
||
data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"><input type="hidden" name="csrfmiddlewaretoken" value="DqW5iuhCWCemqhY893KAfqzkOPEmjdo7UdGaVkKYwd1QkI4YMmnCJy5YmTmycOWr"><div class="choice-group" role="radiogroup"><ul class="radio-group-items"><li><input type="radio"
|
||
id="collections-action-dialog-new"
|
||
class="collections-new"
|
||
name="collections"
|
||
value="new"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="collections_radio_new"><label for="collections-action-dialog-new">Create a new collection</label></li><li><input type="radio"
|
||
id="collections-action-dialog-existing"
|
||
class="collections-existing"
|
||
name="collections"
|
||
value="existing"
|
||
checked="true"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li></ul></div><div class="controls-wrapper"><div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk">
|
||
Name your collection:
|
||
</label><input
|
||
type="text"
|
||
name="add-to-new-collection"
|
||
id="collections-action-dialog-add-to-new"
|
||
class="collections-action-add-to-new"
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"
|
||
maxlength="100"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="create_collection"
|
||
data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message">
|
||
Name must be less than 100 characters
|
||
</div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label">
|
||
Choose a collection:
|
||
</label><select id="collections-action-dialog-add-to-existing"
|
||
class="action-panel-selector collections-action-add-to-existing"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="select_collection"
|
||
data-ga-label="($('.collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"></select><div class="collections-retry-load-on-error usa-input-error-message selection-validation-message">
|
||
Unable to load your collection due to an error<br><a href="#">Please try again</a></div></div></div><div class="action-panel-actions"><button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Adding..."
|
||
data-pinger-ignore
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="add">
|
||
Add
|
||
</button><button class="action-panel-cancel"
|
||
aria-label="Close 'Add to Collections' panel"
|
||
ref="linksrc=close_collections_panel"
|
||
aria-controls="collections-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button></div></form></div></div></div></div><button class="more-actions-button more-actions-dialog-trigger"
|
||
title="Open dialog with more actions to take"
|
||
ref="linksrc=more_actions_btn"></button><div class="display-options" data-format-key="format"
|
||
data-default-format-value="abstract"
|
||
data-current-format-value="abstract" role="region"><button
|
||
class="trigger usa-button"
|
||
title="Change format"
|
||
data-ga-category="display_options"
|
||
data-ga-action="display_options_dialog"><span class="button-label">Display options</span></button><div class="dropdown" hidden><div class="title">
|
||
Display options
|
||
</div><div class="content"><div class="format-container"><span class="option-label">
|
||
Format
|
||
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</a></li></ul></div></div></div><span class="period">. </span><span class="cit">2019 Feb 25;2(2):CD013273.</span>
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Paracetamol versus placebo for knee and hip osteoarthritis
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<div class="publication-type" >Meta-Analysis</div>
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<h1 class="heading-title">
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Paracetamol versus placebo for knee and hip osteoarthritis
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</h1>
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<span class="authors-list-item "><span class="full-name">Amanda O Leopoldino</span><span class="citation-separator"> et al.</span></span>
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</a></li></ul></div></div></div><span class="period">. </span><span class="cit">2019 Feb 25;2(2):CD013273.</span>
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|
||
Background:
|
||
</strong>
|
||
|
||
Paracetamol (acetaminophen) is vastly recommended as the first-line analgesic for osteoarthritis of the hip or knee. However, there has been controversy about this recommendation given recent studies have revealed small effects of paracetamol when compared with placebo. Nonetheless, past studies have not systematically reviewed and appraised the literature to investigate the effects of this drug on specific osteoarthritis sites, that is, hip or knee, or on the dose used.
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Objectives:
|
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</strong>
|
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|
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To assess the benefits and harms of paracetamol compared with placebo in the treatment of osteoarthritis of the hip or knee.
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</p>
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<p>
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Search methods:
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|
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We searched the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, AMED, CINAHL, Web of Science, LILACS, and International Pharmaceutical Abstracts to 3 October 2017, and ClinicalTrials.gov and the World Health Organization International Clinical Trials Registry Platform (ICTRP) portal on 20 October 2017.
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<p>
|
||
|
||
<strong class="sub-title">
|
||
Selection criteria:
|
||
</strong>
|
||
|
||
We included randomised controlled trials comparing paracetamol with placebo in adults with osteoarthritis of the hip or knee. Major outcomes were pain, function, quality of life, adverse events and withdrawals due to adverse events, serious adverse events, and abnormal liver function tests.
|
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</p>
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<p>
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|
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Data collection and analysis:
|
||
</strong>
|
||
|
||
Two review authors used standard Cochrane methods to collect data, and assess risk of bias and quality of the evidence. For pooling purposes, we converted pain and physical function (Western Ontario and McMaster Universities Osteoarthritis Index function) scores to a common 0 (no pain or disability) to 100 (worst possible pain or disability) scale.
|
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<strong class="sub-title">
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Main results:
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|
||
We identified 10 randomised placebo-controlled trials involving 3541 participants with hip or knee osteoarthritis. The paracetamol dose varied from 1.95 g/day to 4 g/day, and the majority of trials followed participants for three months only. Most trials did not clearly report randomisation and concealment methods and were at unclear risk of selection bias. Trials were at low risk of performance, detection, and reporting bias.At 3 weeks' to 3 months' follow-up, there was high-quality evidence that paracetamol provided no clinically important improvements in pain and physical function. Mean reduction in pain was 23 points (0 to 100 scale, lower scores indicated less pain) with placebo and 3.23 points better (5.43 better to 1.02 better) with paracetamol, an absolute reduction of 3% (1% better to 5% better, minimal clinical important difference 9%) and relative reduction of 5% (2% better to 8% better) (seven trials, 2355 participants). Physical function improved by 12 points on a 0 to 100 scale (lower scores indicated better function) with placebo and was 2.9 points better (0.95 better to 4.89 better) with paracetamol, an absolute improvement of 3% (1% better to 5% better, minimal clinical important difference 10%) and relative improvement of 5% (2% better to 9% better) (7 trials, 2354 participants).High-quality evidence from eight trials indicated that the incidence of adverse events was similar between groups: 515/1586 (325 per 1000) in the placebo group versus 537/1666 (328 per 1000, range 299 to 360) in the paracetamol group (risk ratio (RR) 1.01, 95% confidence interval (CI) 0.92 to 1.11). There was less certainty (moderate-quality evidence) around the risk of serious adverse events, withdrawals due to adverse events, and the rate of abnormal liver function tests, due to wide CIs or small event rates, indicating imprecision. Seventeen of 1480 (11 per 1000) people treated with placebo and 28/1729 (16 per 1000, range 8 to 29) people treated with paracetamol experienced serious adverse events (RR 1.36, 95% CI 0.73 to 2.53; 6 trials). The incidence of withdrawals due to adverse events was 65/1000 participants in with placebo and 77/1000 (range 59 to 100) participants with paracetamol (RR 1.19, 95% CI 0.91 to 1.55; 7 trials). Abnormal liver function occurred in 18/1000 participants treated with placebo and 70/1000 participants treated with paracetamol (RR 3.79, 95% CI 1.94 to 7.39), but the clinical importance of this effect was uncertain. None of the trials reported quality of life.Subgroup analyses indicated that the effects of paracetamol on pain and function did not differ according to the dose of paracetamol (3.0 g/day or less versus 3.9 g/day or greater).
|
||
</p>
|
||
|
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|
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|
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|
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|
||
<p>
|
||
|
||
<strong class="sub-title">
|
||
Authors' conclusions:
|
||
</strong>
|
||
|
||
Based on high-quality evidence this review confirms that paracetamol provides only minimal improvements in pain and function for people with hip or knee osteoarthritis, with no increased risk of adverse events overall. Subgroup analysis indicates that the effects on pain and function do not differ according to the dose of paracetamol. Due to the small number of events, we are less certain if paracetamol use increases the risk of serious adverse events, withdrawals due to adverse events, and rate of abnormal liver function tests.Current clinical guidelines consistently recommend paracetamol as the first-line analgesic medication for hip or knee osteoarthritis, given its low absolute frequency of substantive harm. However, our results call for reconsideration of these recommendations.
|
||
</p>
|
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<p class="disclaimer" id="disclaimer">
|
||
<a href="/disclaimer/" target="_blank" data-ga-category="literature_resources"
|
||
data-ga-action="disclaimer_link" data-ga-label="under_abstract">PubMed Disclaimer</a>
|
||
</p>
|
||
|
||
<div class="conflict-of-interest" id="conflict-of-interest">
|
||
<h2 class="title">
|
||
Conflict of interest statement
|
||
</h2>
|
||
|
||
<div class="statement">
|
||
|
||
|
||
|
||
<p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">AOL: no conflict of interest.</p>
|
||
|
||
<p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">GCM, MBP, PHF, ROD, AJM, and MLF: conducted a systematic review that investigated the benefits of paracetamol for patients with osteoarthritis and spinal pain published in the <italic>BMJ</italic>.</p>
|
||
|
||
<p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">ROD and AJM: investigators on the PACE (Placebo, Acetaminophen (paracetamol) or Celecoxib Efficacy Studies) trial of paracetamol in low back pain which was jointly funded by the National Health and Medical Research Council of Australia and GlaxoSmithKline Australia (a manufacturer of paracetamol).</p>
|
||
|
||
<p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">AM: received research funding support from GlaxoSmithKline for a PhD scholarship.</p>
|
||
|
||
<p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">DJH is a consultant for Flexion, Merck Serono, and Nestlé.</p>
|
||
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||
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|
||
</div>
|
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|
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|
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|
||
id="article-image-0"
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src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/999cbeebbee5/nCD013273-AFig-FIG01.gif"
|
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|
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<p> 1 </p>
|
||
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|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Prisma flow diagram of trials investigating… </p></div>
|
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|
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|
||
<p> 1 </p>
|
||
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|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Prisma flow diagram of trials investigating efficacy of paracetamol versus placebo for osteoarthritis. </p></div>
|
||
|
||
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|
||
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|
||
1
|
||
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|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Prisma flow diagram of trials investigating efficacy of paracetamol versus placebo for osteoarthritis.</div>
|
||
|
||
|
||
|
||
|
||
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|
||
|
||
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||
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|
||
<p> 2 </p>
|
||
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|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Risk of bias summary: review authors'… </p></div>
|
||
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||
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|
||
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|
||
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|
||
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|
||
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|
||
<p> 2 </p>
|
||
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|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Risk of bias summary: review authors' judgements about each risk of bias item for… </p></div>
|
||
|
||
|
||
|
||
|
||
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|
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|
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|
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|
||
2
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Risk of bias summary: review authors' judgements about each risk of bias item for each included study.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
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|
||
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||
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|
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|
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src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/57f2ba4bf51b/nCD013273-AFig-FIG03.gif"
|
||
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|
||
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|
||
<p> 3 </p>
|
||
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|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Risk of bias graph: review authors'… </p></div>
|
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|
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|
||
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|
||
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|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Risk of bias graph: review authors' judgements about each risk of bias item presented… </p></div>
|
||
|
||
|
||
|
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|
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|
||
3
|
||
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|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.</div>
|
||
|
||
|
||
|
||
|
||
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|
||
|
||
|
||
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|
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|
||
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|
||
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|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Forest plot of comparison: 1 Hip… </p></div>
|
||
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||
|
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||
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|
||
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|
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|
||
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|
||
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|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Forest plot of comparison: 1 Hip or knee osteoarthritis, outcome: 1.1 Pain. Pain scores… </p></div>
|
||
|
||
|
||
|
||
|
||
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|
||
|
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|
||
4
|
||
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|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Forest plot of comparison: 1 Hip or knee osteoarthritis, outcome: 1.1 Pain. Pain scores are expressed on scale of 0 to 100. Immediate term = follow‐up two weeks or less; short term = follow‐up more than two weeks but three months or less.</div>
|
||
|
||
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||
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|
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|
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|
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|
||
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|
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|
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|
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|
||
<div class="figure-caption-contents"><p> Forest plot of comparison: 1 Hip… </p></div>
|
||
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|
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|
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|
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|
||
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|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Forest plot of comparison: 1 Hip or knee osteoarthritis, outcome: 1.2 Physical function (WOMAC).… </p></div>
|
||
|
||
|
||
|
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|
||
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|
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5
|
||
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|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Forest plot of comparison: 1 Hip or knee osteoarthritis, outcome: 1.2 Physical function (WOMAC). Physical function scores expressed on scale of 0 to 100. Immediate term = follow‐up two weeks or less; short term = follow‐up two weeks or greater but three months or less.</div>
|
||
|
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|
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|
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|
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|
||
data-label-slug="6">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/7e6a498fabc3/nCD013273-AFig-FIG06.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-5"
|
||
role="button"
|
||
data-image-width="574"
|
||
data-image-height="565"
|
||
data-image-alt="6"
|
||
data-pmc-id="PMC6388567"
|
||
data-figure-id="CD013273-fig-0006">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-5"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/f5a2b06f9f24/nCD013273-AFig-FIG06.gif"
|
||
alt="6" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="574">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="565">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> 6 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Forest plot of comparison: 1 Hip… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> 6 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Forest plot of comparison: 1 Hip or knee osteoarthritis, outcome: 1.4 Adverse events (AE).… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-5" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
6
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Forest plot of comparison: 1 Hip or knee osteoarthritis, outcome: 1.4 Adverse events (AE). Any = number of participants reporting any AE; serious = number of participants reporting any serious AE (as defined by each study); withdrawals = number of participants withdrawn from study because of AEs; liver = number of participants with abnormal results on liver function tests.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="6"
|
||
data-label-slug="11">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/71a8e8567a26/nCD013273-CMP-001-01.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-6"
|
||
role="button"
|
||
data-image-width="566"
|
||
data-image-height="350"
|
||
data-image-alt="1.1"
|
||
data-pmc-id="PMC6388567"
|
||
data-figure-id="CD013273-fig-0007">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-6"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/7bfcb70ed76e/nCD013273-CMP-001-01.gif"
|
||
alt="1.1" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="566">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="350">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> 1.1. Analysis </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Comparison 1 Hip or knee… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> 1.1. Analysis </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Comparison 1 Hip or knee osteoarthritis, Outcome 1 Pain intensity. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-6" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
1.1. Analysis
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Comparison 1 Hip or knee osteoarthritis, Outcome 1 Pain intensity.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="7"
|
||
data-label-slug="12">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/700473789d49/nCD013273-CMP-001-02.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-7"
|
||
role="button"
|
||
data-image-width="566"
|
||
data-image-height="326"
|
||
data-image-alt="1.2"
|
||
data-pmc-id="PMC6388567"
|
||
data-figure-id="CD013273-fig-0008">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-7"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/6f2abc5dfd0e/nCD013273-CMP-001-02.gif"
|
||
alt="1.2" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="566">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="326">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> 1.2. Analysis </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Comparison 1 Hip or knee… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> 1.2. Analysis </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Comparison 1 Hip or knee osteoarthritis, Outcome 2 Physical function (Western Ontario and… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-7" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
1.2. Analysis
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Comparison 1 Hip or knee osteoarthritis, Outcome 2 Physical function (Western Ontario and McMaster Universities Osteoarthritis Index).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="8"
|
||
data-label-slug="13">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/9739d3d0a5cb/nCD013273-CMP-001-03.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-8"
|
||
role="button"
|
||
data-image-width="566"
|
||
data-image-height="541"
|
||
data-image-alt="1.3"
|
||
data-pmc-id="PMC6388567"
|
||
data-figure-id="CD013273-fig-0009">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-8"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/d4ea7e8acf7a/nCD013273-CMP-001-03.gif"
|
||
alt="1.3" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="566">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="541">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> 1.3. Analysis </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Comparison 1 Hip or knee… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> 1.3. Analysis </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Comparison 1 Hip or knee osteoarthritis, Outcome 3 Adverse events (AE). </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-8" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
1.3. Analysis
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Comparison 1 Hip or knee osteoarthritis, Outcome 3 Adverse events (AE).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="9"
|
||
data-label-slug="14">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/9cb1aeeb18ca/nCD013273-CMP-001-04.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-9"
|
||
role="button"
|
||
data-image-width="566"
|
||
data-image-height="197"
|
||
data-image-alt="1.4"
|
||
data-pmc-id="PMC6388567"
|
||
data-figure-id="CD013273-fig-0010">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-9"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/f78992814c78/nCD013273-CMP-001-04.gif"
|
||
alt="1.4" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="566">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="197">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> 1.4. Analysis </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Comparison 1 Hip or knee… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> 1.4. Analysis </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Comparison 1 Hip or knee osteoarthritis, Outcome 4 Walking disability. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-9" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
1.4. Analysis
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Comparison 1 Hip or knee osteoarthritis, Outcome 4 Walking disability.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="10"
|
||
data-label-slug="15">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/ad700b4f08fc/nCD013273-CMP-001-05.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-10"
|
||
role="button"
|
||
data-image-width="566"
|
||
data-image-height="119"
|
||
data-image-alt="1.5"
|
||
data-pmc-id="PMC6388567"
|
||
data-figure-id="CD013273-fig-0011">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-10"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/ae8ac5b0f9b1/nCD013273-CMP-001-05.gif"
|
||
alt="1.5" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="566">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="119">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> 1.5. Analysis </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Comparison 1 Hip or knee… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> 1.5. Analysis </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Comparison 1 Hip or knee osteoarthritis, Outcome 5 Rescue medication. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-10" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
1.5. Analysis
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Comparison 1 Hip or knee osteoarthritis, Outcome 5 Rescue medication.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="11"
|
||
data-label-slug="16">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/9e0badb15f0f/nCD013273-CMP-001-06.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-11"
|
||
role="button"
|
||
data-image-width="566"
|
||
data-image-height="119"
|
||
data-image-alt="1.6"
|
||
data-pmc-id="PMC6388567"
|
||
data-figure-id="CD013273-fig-0012">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-11"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/edbf9b17f305/nCD013273-CMP-001-06.gif"
|
||
alt="1.6" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="566">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="119">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> 1.6. Analysis </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Comparison 1 Hip or knee… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> 1.6. Analysis </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Comparison 1 Hip or knee osteoarthritis, Outcome 6 Patient adherence. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-11" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
1.6. Analysis
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Comparison 1 Hip or knee osteoarthritis, Outcome 6 Patient adherence.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="12"
|
||
data-label-slug="21">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/2619e788ef39/nCD013273-CMP-002-01.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-12"
|
||
role="button"
|
||
data-image-width="566"
|
||
data-image-height="245"
|
||
data-image-alt="2.1"
|
||
data-pmc-id="PMC6388567"
|
||
data-figure-id="CD013273-fig-0013">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-12"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/fd276e84910d/nCD013273-CMP-002-01.gif"
|
||
alt="2.1" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="566">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="245">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> 2.1. Analysis </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Comparison 2 Knee osteoarthritis, Outcome… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> 2.1. Analysis </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Comparison 2 Knee osteoarthritis, Outcome 1 Pain intensity. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-12" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
2.1. Analysis
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Comparison 2 Knee osteoarthritis, Outcome 1 Pain intensity.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="13"
|
||
data-label-slug="22">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/b630d55d86e0/nCD013273-CMP-002-02.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-13"
|
||
role="button"
|
||
data-image-width="566"
|
||
data-image-height="233"
|
||
data-image-alt="2.2"
|
||
data-pmc-id="PMC6388567"
|
||
data-figure-id="CD013273-fig-0014">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-13"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/07411cccd66f/nCD013273-CMP-002-02.gif"
|
||
alt="2.2" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="566">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="233">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> 2.2. Analysis </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Comparison 2 Knee osteoarthritis, Outcome… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> 2.2. Analysis </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Comparison 2 Knee osteoarthritis, Outcome 2 Physical function (Western Ontario and McMaster Universities… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-13" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
2.2. Analysis
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Comparison 2 Knee osteoarthritis, Outcome 2 Physical function (Western Ontario and McMaster Universities Osteoarthritis Index).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="14"
|
||
data-label-slug="23">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/04aedf238b22/nCD013273-CMP-002-03.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-14"
|
||
role="button"
|
||
data-image-width="566"
|
||
data-image-height="197"
|
||
data-image-alt="2.3"
|
||
data-pmc-id="PMC6388567"
|
||
data-figure-id="CD013273-fig-0015">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-14"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/ac050616ace4/nCD013273-CMP-002-03.gif"
|
||
alt="2.3" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="566">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="197">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> 2.3. Analysis </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Comparison 2 Knee osteoarthritis, Outcome… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> 2.3. Analysis </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Comparison 2 Knee osteoarthritis, Outcome 3 Walking disability. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-14" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
2.3. Analysis
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Comparison 2 Knee osteoarthritis, Outcome 3 Walking disability.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="15"
|
||
data-label-slug="31">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/0a0ac5b228de/nCD013273-CMP-003-01.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-15"
|
||
role="button"
|
||
data-image-width="566"
|
||
data-image-height="233"
|
||
data-image-alt="3.1"
|
||
data-pmc-id="PMC6388567"
|
||
data-figure-id="CD013273-fig-0016">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-15"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/c962fa58b3df/nCD013273-CMP-003-01.gif"
|
||
alt="3.1" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="566">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="233">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> 3.1. Analysis </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Comparison 3 Subgroup analysis: paracetamol… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> 3.1. Analysis </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Comparison 3 Subgroup analysis: paracetamol 3.0 g/day or less versus 3.9 g/day or… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-15" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
3.1. Analysis
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Comparison 3 Subgroup analysis: paracetamol 3.0 g/day or less versus 3.9 g/day or more, Outcome 1 Pain intensity: immediate term.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="16"
|
||
data-label-slug="32">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/df017f43e31f/nCD013273-CMP-003-02.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-16"
|
||
role="button"
|
||
data-image-width="566"
|
||
data-image-height="290"
|
||
data-image-alt="3.2"
|
||
data-pmc-id="PMC6388567"
|
||
data-figure-id="CD013273-fig-0017">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-16"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/301238523086/nCD013273-CMP-003-02.gif"
|
||
alt="3.2" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="566">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="290">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> 3.2. Analysis </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Comparison 3 Subgroup analysis: paracetamol… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> 3.2. Analysis </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Comparison 3 Subgroup analysis: paracetamol 3.0 g/day or less versus 3.9 g/day or… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-16" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
3.2. Analysis
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Comparison 3 Subgroup analysis: paracetamol 3.0 g/day or less versus 3.9 g/day or more, Outcome 2 Pain intensity: short term.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="17"
|
||
data-label-slug="33">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/4d422ffbeeeb/nCD013273-CMP-003-03.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-17"
|
||
role="button"
|
||
data-image-width="566"
|
||
data-image-height="169"
|
||
data-image-alt="3.3"
|
||
data-pmc-id="PMC6388567"
|
||
data-figure-id="CD013273-fig-0018">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-17"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/4911e742b5d1/nCD013273-CMP-003-03.gif"
|
||
alt="3.3" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="566">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="169">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> 3.3. Analysis </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Comparison 3 Subgroup analysis: paracetamol… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> 3.3. Analysis </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Comparison 3 Subgroup analysis: paracetamol 3.0 g/day or less versus 3.9 g/day or… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-17" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
3.3. Analysis
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Comparison 3 Subgroup analysis: paracetamol 3.0 g/day or less versus 3.9 g/day or more, Outcome 3 Physical function: immediate term.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="18"
|
||
data-label-slug="34">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/e81c315a2bb6/nCD013273-CMP-003-04.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-18"
|
||
role="button"
|
||
data-image-width="566"
|
||
data-image-height="290"
|
||
data-image-alt="3.4"
|
||
data-pmc-id="PMC6388567"
|
||
data-figure-id="CD013273-fig-0019">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-18"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe9/6388567/4395743afd8a/nCD013273-CMP-003-04.gif"
|
||
alt="3.4" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="566">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="290">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> 3.4. Analysis </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Comparison 3 Subgroup analysis: paracetamol… </p></div>
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<strong class="figure-label">
|
||
<p> 3.4. Analysis </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Comparison 3 Subgroup analysis: paracetamol 3.0 g/day or less versus 3.9 g/day or… </p></div>
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3.4. Analysis
|
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|
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||
<div class="figure-caption-contents">Comparison 3 Subgroup analysis: paracetamol 3.0 g/day or less versus 3.9 g/day or more, Outcome 4 Physical function: short term.</div>
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Paracetamol as first line for treatment of knee and hip osteoarthritis.
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Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
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<div class="docsum-citation full-citation">
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<span class="docsum-authors full-authors">Jones P, Lamdin R, Dalziel SR.</span>
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<span class="docsum-authors short-authors">Jones P, et al.</span>
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<span class="docsum-journal-citation full-journal-citation">Cochrane Database Syst Rev. 2020 Aug 12;8(8):CD007789. doi: 10.1002/14651858.CD007789.pub3.</span>
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<span class="docsum-journal-citation short-journal-citation">Cochrane Database Syst Rev. 2020.</span>
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<span class="citation-part">PMID: <span class="docsum-pmid">32797734</span></span>
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New Trends in Pharmacological Treatments for Osteoarthritis.
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<span class="docsum-authors full-authors">Cai X, Yuan S, Zeng Y, Wang C, Yu N, Ding C.</span>
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<span class="docsum-authors short-authors">Cai X, et al.</span>
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<span class="docsum-journal-citation full-journal-citation">Front Pharmacol. 2021 Apr 15;12:645842. doi: 10.3389/fphar.2021.645842. eCollection 2021.</span>
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<span class="docsum-journal-citation short-journal-citation">Front Pharmacol. 2021.</span>
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|
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<span class="citation-part">PMID: <span class="docsum-pmid">33935742</span></span>
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<span class="free-resources spaced-citation-item citation-part">Free PMC article.</span>
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<span class="publication-type spaced-citation-item citation-part">Review.</span>
|
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||
</div>
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</div>
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</li>
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<li class="full-docsum">
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Nortriptyline for pain in knee osteoarthritis: a double-blind randomised controlled trial in New Zealand general practice.
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</a>
|
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|
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|
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|
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<span class="docsum-authors full-authors">Hudson B, Williman JA, Stamp LK, Alchin JS, Hooper GJ, Mangin D, Thompson BFL, Toop L.</span>
|
||
|
||
|
||
|
||
<span class="docsum-authors short-authors">Hudson B, et al.</span>
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||
<span class="docsum-journal-citation full-journal-citation">Br J Gen Pract. 2021 Jun 24;71(708):e538-e546. doi: 10.3399/BJGP.2020.0797. Print 2021 Jul.</span>
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<span class="docsum-journal-citation short-journal-citation">Br J Gen Pract. 2021.</span>
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<span class="citation-part">PMID: <span class="docsum-pmid">33571950</span></span>
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<span class="free-resources spaced-citation-item citation-part">Free PMC article.</span>
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<span class="publication-type spaced-citation-item citation-part">Clinical Trial.</span>
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</div>
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</li>
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<li class="full-docsum">
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PEER umbrella systematic review of systematic reviews: Management of osteoarthritis in primary care.
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|
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</a>
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<span class="docsum-authors full-authors">Ton J, Perry D, Thomas B, Allan GM, Lindblad AJ, McCormack J, Kolber MR, Garrison S, Moe S, Craig R, Dugré N, Chan K, Finley CR, Ting R, Korownyk CS.</span>
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||
|
||
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||
|
||
<span class="docsum-authors short-authors">Ton J, et al.</span>
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||
<span class="docsum-journal-citation full-journal-citation">Can Fam Physician. 2020 Mar;66(3):e89-e98.</span>
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||
<span class="docsum-journal-citation short-journal-citation">Can Fam Physician. 2020.</span>
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||
|
||
|
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<span class="citation-part">PMID: <span class="docsum-pmid">32165479</span></span>
|
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<span class="free-resources spaced-citation-item citation-part">Free PMC article.</span>
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</div>
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<div class="references" id="references">
|
||
<h2 class="title">
|
||
References
|
||
</h2>
|
||
<div id='top-references-list' class="references-lists-container">
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h4 class="refs-list-title">References to studies included in this review</h4>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">Altman 2007 {published data only}</h5>
|
||
|
||
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<ol id="top-references-list-2" class="references-list">
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value="1">
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Altman RD, Zinsenheim JR, Temple AR, Schweinle JE. Three‐month efficacy and safety of acetaminophen extended‐release for osteoarthritis pain of the hip or knee: a randomized, double‐blind, placebo‐controlled study. Osteoarthritis and Cartilage 2007;15:454‐61.
|
||
|
||
|
||
|
||
-
|
||
<a
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class="reference-link"
|
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href="/17142063/"
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ref="linksrc=references_link&ordinalpos=1"
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PubMed
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</ol>
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</li>
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</ol>
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||
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||
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||
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||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">Amadio 1983 {published data only}</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-3" class="references-list">
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||
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||
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||
<li>
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||
<ol class="references-and-notes-list">
|
||
|
||
<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
Amadio P, Doyle M. Evaluation of acetaminophen in the management of osteoarthritis of the knee. Current Therapeutic Research – Clinical and Experimental 1983;34(1):59‐66.
|
||
|
||
|
||
</li>
|
||
|
||
</ol>
|
||
</li>
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||
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</ol>
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||
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||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">Case 2003 {published data only}</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-4" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
|
||
<ol class="references-and-notes-list">
|
||
|
||
<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
Case JP, Baliunas AJ, Block JA. Lack of efficacy of acetaminophen in treating symptomatic knee osteoarthritis: a randomized, double‐blind, placebo‐controlled comparison trial with diclofenac sodium. Archives of Internal Medicine 2003;163(2):169‐78.
|
||
|
||
|
||
|
||
-
|
||
<a
|
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class="reference-link"
|
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href="/12546607/"
|
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ref="linksrc=references_link&ordinalpos=1"
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</ol>
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||
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||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">Golden 2004 {published data only}</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-5" class="references-list">
|
||
|
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||
|
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<li>
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<ol class="references-and-notes-list">
|
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<li
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||
class="skip-numbering"
|
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value="1">
|
||
|
||
Golden HE, Moskowitz RW, Minic M. Analgesic efficacy and safety of nonprescription doses of naproxen sodium compared with acetaminophen in the treatment of osteoarthritis of the knee. American Journal of Therapeutics 2004;11:85‐94.
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
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href="/14999359/"
|
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ref="linksrc=references_link&ordinalpos=1"
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data-ga-category="reference"
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PubMed
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</li>
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||
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</ol>
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||
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||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">Herrero‐Beaumont 2007 {published data only}</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-6" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
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<ol class="references-and-notes-list">
|
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<li
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||
class="skip-numbering"
|
||
value="1">
|
||
|
||
Herrero‐Beaumont G, Ivorra JA, Carmen Trabado M, Blanco FJ, Benito P, Martín‐Mola E, et al. Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double‐blind, placebo‐controlled study using acetaminophen as a side comparator. Arthritis and Rheumatism 2007;56(2):555‐67.
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="/17265490/"
|
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ref="linksrc=references_link&ordinalpos=1"
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data-ga-category="reference"
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>
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PubMed
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|
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</li>
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||
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</ol>
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</li>
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||
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||
</ol>
|
||
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|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">Miceli‐Richard 2004 {published data only}</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-7" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
|
||
<ol class="references-and-notes-list">
|
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|
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<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
Miceli‐Richard C, Bars M, Schmidely N, Dougados M. Paracetamol in osteoarthritis of the knee. Annals of the Rheumatic Diseases 2004;63(8):923‐30.
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC1755093/"
|
||
ref="linksrc=references_link&ordinalpos=1"
|
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data-ga-category="reference"
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data-ga-action="PMC1755093"
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PMC
|
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</a>
|
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|
||
|
||
|
||
|
||
|
||
-
|
||
<a
|
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class="reference-link"
|
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href="/15249319/"
|
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ref="linksrc=references_link&ordinalpos=2"
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data-ga-category="reference"
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PubMed
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</li>
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</ol>
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</li>
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||
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</ol>
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||
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|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">Pincus 2004a {published data only}</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-8" class="references-list">
|
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|
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<li>
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<ol class="references-and-notes-list">
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value="1">
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||
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||
Pincus T, Koch G, Lei H, Mangal B, Mangal B, Sokka T, Moskowitz R, et al. Patient Preference for Placebo, Acetaminophen (paracetamol) or Celecoxib Efficacy Studies (PACES): two randomised, double blind, placebo controlled, crossover clinical trials in patients with knee or hip osteoarthritis. Annals of the Rheumatic Diseases 2004;63(8):931‐9.
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
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href="https://pmc.ncbi.nlm.nih.gov/articles/PMC1755088/"
|
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ref="linksrc=references_link&ordinalpos=1"
|
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data-ga-category="reference"
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data-ga-action="PMC1755088"
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PMC
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</a>
|
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|
||
|
||
|
||
|
||
|
||
-
|
||
<a
|
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class="reference-link"
|
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href="/15082468/"
|
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ref="linksrc=references_link&ordinalpos=2"
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data-ga-category="reference"
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data-ga-action="15082468"
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PubMed
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</a>
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</li>
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|
||
|
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||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">Pincus 2004b {published data only}</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-9" class="references-list">
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<li>
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<ol class="references-and-notes-list">
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<li
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class="skip-numbering"
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value="1">
|
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|
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Pincus T, Koch G, Lei H, Mangal B, Mangal B, Sokka T, Moskowitz R, et al. Patient Preference for Placebo, Acetaminophen (paracetamol) or Celecoxib Efficacy Studies (PACES): two randomised, double blind, placebo controlled, crossover clinical trials in patients with knee or hip osteoarthritis. Annals of the Rheumatic Diseases 2004;63(8):931‐9.
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
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href="https://pmc.ncbi.nlm.nih.gov/articles/PMC1755088/"
|
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ref="linksrc=references_link&ordinalpos=1"
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data-ga-category="reference"
|
||
data-ga-action="PMC1755088"
|
||
>
|
||
PMC
|
||
</a>
|
||
|
||
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="/15082468/"
|
||
ref="linksrc=references_link&ordinalpos=2"
|
||
data-ga-category="reference"
|
||
data-ga-action="15082468"
|
||
>
|
||
PubMed
|
||
</a>
|
||
|
||
|
||
|
||
|
||
</li>
|
||
|
||
</ol>
|
||
</li>
|
||
|
||
|
||
</ol>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">Prior 2014 {published data only}</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-10" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
|
||
<ol class="references-and-notes-list">
|
||
|
||
<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
Prior MJ, Harrison DD, Frustaci ME. A randomized, double‐blind, placebo‐controlled 12 week trial of acetaminophen extended release for the treatment of signs and symptoms of osteoarthritis. Current Medical Research & Opinion 2014;30(11):2377‐87.
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="/25121804/"
|
||
ref="linksrc=references_link&ordinalpos=1"
|
||
data-ga-category="reference"
|
||
data-ga-action="25121804"
|
||
>
|
||
PubMed
|
||
</a>
|
||
|
||
|
||
|
||
|
||
</li>
|
||
|
||
</ol>
|
||
</li>
|
||
|
||
|
||
</ol>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">Zoppi 1995 {published data only}</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-11" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
|
||
<ol class="references-and-notes-list">
|
||
|
||
<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
Zoppi M, Peretti G, Boccard E. Placebo‐controlled study of the analgesic efficacy of an effervescent formulation of 500 mg paracetamol in arthritis of the knee or the hip. European Journal of Pain 1995;16:1‐2.
|
||
|
||
|
||
</li>
|
||
|
||
</ol>
|
||
</li>
|
||
|
||
|
||
</ol>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h4 class="refs-list-title">References to studies excluded from this review</h4>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">Ha 2016 {published data only}</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-13" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
|
||
<ol class="references-and-notes-list">
|
||
|
||
<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
Ha CW, Park YB, Min BW, Han SB, Lee JH, Won YY, et al. Prospective, randomized, double‐blinded, double‐dummy and multicenter phase IV clinical study comparing the efficacy and safety of PG201 (Layla) and SKI306X in patients with osteoarthritis. Journal of Ethnopharmacology 2016;181:1‐7.
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="/26821189/"
|
||
ref="linksrc=references_link&ordinalpos=1"
|
||
data-ga-category="reference"
|
||
data-ga-action="26821189"
|
||
>
|
||
PubMed
|
||
</a>
|
||
|
||
|
||
|
||
|
||
</li>
|
||
|
||
</ol>
|
||
</li>
|
||
|
||
|
||
</ol>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">Lao 2015 {published data only}</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-14" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
|
||
<ol class="references-and-notes-list">
|
||
|
||
<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
Lao L, Hochberg M, Lee DY, Gilpin AM, Fong HH, Langenberg P, et al. Huo‐Luo‐Xiao‐Ling (HLXL)‐Dan, a Traditional Chinese Medicine, for patients with osteoarthritis of the knee: a multi‐site, randomized, double‐blind, placebo‐controlled phase II clinical trial. Osteoarthritis and Cartilage 2015;23(12):2102‐8.
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4663117/"
|
||
ref="linksrc=references_link&ordinalpos=1"
|
||
data-ga-category="reference"
|
||
data-ga-action="PMC4663117"
|
||
>
|
||
PMC
|
||
</a>
|
||
|
||
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="/26099553/"
|
||
ref="linksrc=references_link&ordinalpos=2"
|
||
data-ga-category="reference"
|
||
data-ga-action="26099553"
|
||
>
|
||
PubMed
|
||
</a>
|
||
|
||
|
||
|
||
|
||
</li>
|
||
|
||
</ol>
|
||
</li>
|
||
|
||
|
||
</ol>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">Papou 2015 {published data only}</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-15" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
|
||
<ol class="references-and-notes-list">
|
||
|
||
<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
Papou A, Hussain S, McWilliams D, Zhang W, Doherty M. Sensitivity to change of SF‐36 health survey and patient generated index in people with chronic knee pain commenced on oral analgesia: analysis of data from a clinical trial. Annals of the Rheumatic Diseases 2015;74:363.
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="/27995369/"
|
||
ref="linksrc=references_link&ordinalpos=1"
|
||
data-ga-category="reference"
|
||
data-ga-action="27995369"
|
||
>
|
||
PubMed
|
||
</a>
|
||
|
||
|
||
|
||
|
||
</li>
|
||
|
||
</ol>
|
||
</li>
|
||
|
||
|
||
</ol>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">Park 2015 {published data only}</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-16" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
|
||
<ol class="references-and-notes-list">
|
||
|
||
<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
Park YB, Ha CW, Cho SD, Lee MC, Lee JH, Seo SS, et al. A randomized study to compare the efficacy and safety of extended‐release and immediate‐release tramadol HCl/acetaminophen in patients with acute pain following total knee replacement. Current Medical Research and Opinion 2015;31(1):75‐84.
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="/25299350/"
|
||
ref="linksrc=references_link&ordinalpos=1"
|
||
data-ga-category="reference"
|
||
data-ga-action="25299350"
|
||
>
|
||
PubMed
|
||
</a>
|
||
|
||
|
||
|
||
|
||
</li>
|
||
|
||
</ol>
|
||
</li>
|
||
|
||
|
||
</ol>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">Skou 2015 {published data only}</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-17" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
|
||
<ol class="references-and-notes-list">
|
||
|
||
<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
Skou ST, Rasmussen S, Laursen MB, Rathleff MS, Arendt‐Nielsen L, Simonsen O, et al. The efficacy of 12 weeks non‐surgical treatment for patients not eligible for total knee replacement: a randomized controlled trial with 1‐year follow‐up. Osteoarthritis and Cartilage 2015;23(9):1465‐75.
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="/25937024/"
|
||
ref="linksrc=references_link&ordinalpos=1"
|
||
data-ga-category="reference"
|
||
data-ga-action="25937024"
|
||
>
|
||
PubMed
|
||
</a>
|
||
|
||
|
||
|
||
|
||
</li>
|
||
|
||
</ol>
|
||
</li>
|
||
|
||
|
||
</ol>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">van Tunen 2016 {published data only}</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-18" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
|
||
<ol class="references-and-notes-list">
|
||
|
||
<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
Tunen JA, Leeden M, Bos WH, Cheung J, Esch M, Gerritsen M, et al. Optimization of analgesics for greater exercise therapy participation among patients with knee osteoarthritis and severe pain: a feasibility study. Arthritis Care and Research 2016;68(3):332‐40.
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="/26239403/"
|
||
ref="linksrc=references_link&ordinalpos=1"
|
||
data-ga-category="reference"
|
||
data-ga-action="26239403"
|
||
>
|
||
PubMed
|
||
</a>
|
||
|
||
|
||
|
||
|
||
</li>
|
||
|
||
</ol>
|
||
</li>
|
||
|
||
|
||
</ol>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">Verkleij 2015 {published data only}</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-19" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
|
||
<ol class="references-and-notes-list">
|
||
|
||
<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
Verkleij SP, Luijsterburg PA, Willemsen SP, Koes BW, Bohnen AM, Bierma‐Zeinstra SM. Effectiveness of diclofenac versus paracetamol in knee osteoarthritis: a randomised controlled trial in primary care. British Journal of General Practice 2015;65(637):530‐7.
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4513741/"
|
||
ref="linksrc=references_link&ordinalpos=1"
|
||
data-ga-category="reference"
|
||
data-ga-action="PMC4513741"
|
||
>
|
||
PMC
|
||
</a>
|
||
|
||
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="/26212849/"
|
||
ref="linksrc=references_link&ordinalpos=2"
|
||
data-ga-category="reference"
|
||
data-ga-action="26212849"
|
||
>
|
||
PubMed
|
||
</a>
|
||
|
||
|
||
|
||
|
||
</li>
|
||
|
||
</ol>
|
||
</li>
|
||
|
||
|
||
</ol>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">Zheng 2015 {published data only}</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-20" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
|
||
<ol class="references-and-notes-list">
|
||
|
||
<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
Zheng Y, Kostenbader K, Barrett T, Hisaw E, Giuliani MJ, Chen Y, Young JL. Tolerability of biphasic‐release hydrocodone bitartrate/acetaminophen tablets (MNK‐155): a phase III, multicenter, open‐label study in patients with osteoarthritis or chronic low back pain. Clinical Therapeutics 2015;1(37):1235‐47.
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="/25913923/"
|
||
ref="linksrc=references_link&ordinalpos=1"
|
||
data-ga-category="reference"
|
||
data-ga-action="25913923"
|
||
>
|
||
PubMed
|
||
</a>
|
||
|
||
|
||
|
||
|
||
</li>
|
||
|
||
</ol>
|
||
</li>
|
||
|
||
|
||
</ol>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h4 class="refs-list-title">References to ongoing studies</h4>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">ACTRN12613000840785 {published data only}</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-22" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
|
||
<ol class="references-and-notes-list">
|
||
|
||
<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
A randomized, blinded, comparator‐controlled trial investigating a 28‐day course of Lyrica in participants with knee osteoarthritis who exhibit neuropathic pain, compared with a 28‐day course of acetaminophen. Ongoing study 17 June 2013.
|
||
|
||
|
||
</li>
|
||
|
||
</ol>
|
||
</li>
|
||
|
||
|
||
</ol>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">NCT01105936 {published data only}</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-23" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
|
||
<ol class="references-and-notes-list">
|
||
|
||
<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
A randomised, double‐blind, evaluation of the effects of paracetamol on the BOLD fMRI response to painful stimuli in subjects with osteoarthritis. Ongoing study 1 September 2010.
|
||
|
||
|
||
</li>
|
||
|
||
</ol>
|
||
</li>
|
||
|
||
|
||
</ol>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">NCT01420666 {published data only}</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-24" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
|
||
<ol class="references-and-notes-list">
|
||
|
||
<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
Maxi‐Analgesic OA Study: multicentre, double‐blind, placebo‐controlled, randomized, parallel group comparison of the effects of Maxigesic 325 with acetaminophen or ibuprofen on patients with pain from osteoarthritis. Ongoing study 22 August 2011.
|
||
|
||
|
||
</li>
|
||
|
||
</ol>
|
||
</li>
|
||
|
||
|
||
</ol>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">NCT02311881 {published data only}</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-25" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
|
||
<ol class="references-and-notes-list">
|
||
|
||
<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
An efficacy and safety study of sustained‐release paracetamol in subjects with osteoarthritis. Ongoing study 9 December 2014.
|
||
|
||
|
||
</li>
|
||
|
||
</ol>
|
||
</li>
|
||
|
||
|
||
</ol>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">NCT02845271 {published data only}</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-26" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
|
||
<ol class="references-and-notes-list">
|
||
|
||
<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
Proof‐of‐concept study to assess the efficacy, tolerability and safety of a single intraarticular dose of GZ389988 versus placebo in patients with painful osteoarthritis of the knee. Ongoing study 27 July 2016.
|
||
|
||
|
||
</li>
|
||
|
||
</ol>
|
||
</li>
|
||
|
||
|
||
</ol>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h4 class="refs-list-title">Additional references</h4>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">Altman 1996</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-28" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
|
||
<ol class="references-and-notes-list">
|
||
|
||
<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
Altman R, Brandt K, Hochberg M, Moskowitz R, Bellamy N, Bloch DA, et al. Design and conduct of clinical trials in patients with osteoarthritis: recommendations from a task force of the Osteoarthritis Research Society. Results from a workshop. Osteoarthritis Cartilage 1996;4(4):217‐43.
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="/11048620/"
|
||
ref="linksrc=references_link&ordinalpos=1"
|
||
data-ga-category="reference"
|
||
data-ga-action="11048620"
|
||
>
|
||
PubMed
|
||
</a>
|
||
|
||
|
||
|
||
|
||
</li>
|
||
|
||
</ol>
|
||
</li>
|
||
|
||
|
||
</ol>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">Bartels 2016</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-29" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
|
||
<ol class="references-and-notes-list">
|
||
|
||
<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
Bartels E M, Juhl C B, Christensen R, Hagen K B, Danneskiold‐Samsoe B, Dagfinrud H, et al. Aquatic exercise for the treatment of knee and hip osteoarthritis. Cochrane Database of Systematic Reviews 2016, Issue 3. [DOI: 10.1002/14651858.CD005523.pub3]
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="https://doi.org/10.1002/14651858.cd005523.pub3"
|
||
ref="linksrc=references_link&ordinalpos=1"
|
||
data-ga-category="reference"
|
||
data-ga-action="10.1002/14651858.CD005523.pub3"
|
||
>
|
||
DOI
|
||
</a>
|
||
|
||
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC9942938/"
|
||
ref="linksrc=references_link&ordinalpos=2"
|
||
data-ga-category="reference"
|
||
data-ga-action="PMC9942938"
|
||
>
|
||
PMC
|
||
</a>
|
||
|
||
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="/27007113/"
|
||
ref="linksrc=references_link&ordinalpos=3"
|
||
data-ga-category="reference"
|
||
data-ga-action="27007113"
|
||
>
|
||
PubMed
|
||
</a>
|
||
|
||
|
||
|
||
|
||
</li>
|
||
|
||
</ol>
|
||
</li>
|
||
|
||
|
||
</ol>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">Barten 2015</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-30" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
|
||
<ol class="references-and-notes-list">
|
||
|
||
<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
Barten DJ, Dorsman SA, Dekker J, Veenhof C, Bakker DH. Treatment of hip/knee osteoarthritis in Dutch general practice and physical therapy practice: an observational study. BMC Family Practice 2015;16(1):75.
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4483212/"
|
||
ref="linksrc=references_link&ordinalpos=1"
|
||
data-ga-category="reference"
|
||
data-ga-action="PMC4483212"
|
||
>
|
||
PMC
|
||
</a>
|
||
|
||
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="/26116374/"
|
||
ref="linksrc=references_link&ordinalpos=2"
|
||
data-ga-category="reference"
|
||
data-ga-action="26116374"
|
||
>
|
||
PubMed
|
||
</a>
|
||
|
||
|
||
|
||
|
||
</li>
|
||
|
||
</ol>
|
||
</li>
|
||
|
||
|
||
</ol>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">Barthel 2010</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-31" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
|
||
<ol class="references-and-notes-list">
|
||
|
||
<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
Barthel HR, Peniston JH, Clark MB, Gold MS, Altman RD. Correlation of pain relief with physical function in hand osteoarthritis: randomized controlled trial post hoc analysis. Arthritis Research & Therapy 2010;12(1):R7.
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC2875633/"
|
||
ref="linksrc=references_link&ordinalpos=1"
|
||
data-ga-category="reference"
|
||
data-ga-action="PMC2875633"
|
||
>
|
||
PMC
|
||
</a>
|
||
|
||
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="/20064249/"
|
||
ref="linksrc=references_link&ordinalpos=2"
|
||
data-ga-category="reference"
|
||
data-ga-action="20064249"
|
||
>
|
||
PubMed
|
||
</a>
|
||
|
||
|
||
|
||
|
||
</li>
|
||
|
||
</ol>
|
||
</li>
|
||
|
||
|
||
</ol>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">Basedow 2015</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-32" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
|
||
<ol class="references-and-notes-list">
|
||
|
||
<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
Basedow M, Williams H, Shanahan EM, Runciman WB, Esterman A. Australian GP management of osteoarthritis following the release of the RACGP guideline for the non‐surgical management of hip and knee osteoarthritis. BMC Research Notes 2015;5(8):536.
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4593191/"
|
||
ref="linksrc=references_link&ordinalpos=1"
|
||
data-ga-category="reference"
|
||
data-ga-action="PMC4593191"
|
||
>
|
||
PMC
|
||
</a>
|
||
|
||
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="/26438323/"
|
||
ref="linksrc=references_link&ordinalpos=2"
|
||
data-ga-category="reference"
|
||
data-ga-action="26438323"
|
||
>
|
||
PubMed
|
||
</a>
|
||
|
||
|
||
|
||
|
||
</li>
|
||
|
||
</ol>
|
||
</li>
|
||
|
||
|
||
</ol>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">Brand 2008</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-33" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
|
||
<ol class="references-and-notes-list">
|
||
|
||
<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
Brand CA. The role of self‐management in designing care for people with osteoarthritis of the hip and knee. Medical Journal of Australia 2008;189(S):25‐8.
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="/19143581/"
|
||
ref="linksrc=references_link&ordinalpos=1"
|
||
data-ga-category="reference"
|
||
data-ga-action="19143581"
|
||
>
|
||
PubMed
|
||
</a>
|
||
|
||
|
||
|
||
|
||
</li>
|
||
|
||
</ol>
|
||
</li>
|
||
|
||
|
||
</ol>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">Brand 2014</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-34" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
|
||
<ol class="references-and-notes-list">
|
||
|
||
<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
Brand CA, Harrison C, Tropea J, Hinman RS, Britt H, Bennell K. Management of osteoarthritis in general practice in Australia. Arthritis Care and Research 2014;66:551‐8.
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="/24127305/"
|
||
ref="linksrc=references_link&ordinalpos=1"
|
||
data-ga-category="reference"
|
||
data-ga-action="24127305"
|
||
>
|
||
PubMed
|
||
</a>
|
||
|
||
|
||
|
||
|
||
</li>
|
||
|
||
</ol>
|
||
</li>
|
||
|
||
|
||
</ol>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">Buckwalter 2006</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-35" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
|
||
<ol class="references-and-notes-list">
|
||
|
||
<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
Buckwalter JA, Martin JA. Osteoarthritis. Advanced Drug Delivery Reviews 2006;20(58):150‐67.
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="/16530881/"
|
||
ref="linksrc=references_link&ordinalpos=1"
|
||
data-ga-category="reference"
|
||
data-ga-action="16530881"
|
||
>
|
||
PubMed
|
||
</a>
|
||
|
||
|
||
|
||
|
||
</li>
|
||
|
||
</ol>
|
||
</li>
|
||
|
||
|
||
</ol>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">Crofford 2001</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-36" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
|
||
<ol class="references-and-notes-list">
|
||
|
||
<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
Crofford LJ. Rational use of analgesic and antiinflammatory drugs. New England Journal of Medicine 2001;20(345):1844‐6.
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="/11752364/"
|
||
ref="linksrc=references_link&ordinalpos=1"
|
||
data-ga-category="reference"
|
||
data-ga-action="11752364"
|
||
>
|
||
PubMed
|
||
</a>
|
||
|
||
|
||
|
||
|
||
</li>
|
||
|
||
</ol>
|
||
</li>
|
||
|
||
|
||
</ol>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="refs-list">
|
||
|
||
|
||
|
||
<h5 class="refs-list-title">Cross 2014</h5>
|
||
|
||
|
||
|
||
|
||
|
||
<ol id="top-references-list-37" class="references-list">
|
||
|
||
|
||
|
||
|
||
|
||
<li>
|
||
<ol class="references-and-notes-list">
|
||
|
||
<li
|
||
class="skip-numbering"
|
||
value="1">
|
||
|
||
Cross M, Smith E, Hoy D, Nolte S, Ackerman I, Fransen M, et al. The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study. Annals of the Rheumatic Diseases 2014;73:1323‐30.
|
||
|
||
|
||
|
||
-
|
||
<a
|
||
class="reference-link"
|
||
href="/24553908/"
|
||
ref="linksrc=references_link&ordinalpos=1"
|
||
data-ga-category="reference"
|
||
data-ga-action="24553908"
|
||
>
|
||
PubMed
|
||
</a>
|
||
|
||
|
||
|
||
|
||
</li>
|
||
|
||
</ol>
|
||
</li>
|
||
|
||
|
||
</ol>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
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class="reference-link"
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PMC
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PMC
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Zhang WG, Nuki RW, Moskowitz S, Abramson RD, Altman NK, Arden S, et al. OARSI recommendations for the management of hip and knee osteoarthritis: part III: changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis and Cartilage 2010;18(4):476‐99.
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Publication types
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data-pinger-ignore>
|
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Arthralgia / drug therapy*
|
||
</button><div id="keyword-actions-mesh-terms-major-7"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
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aria-label="Dropdown menu for keyword Arthralgia / drug therapy*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Arthralgia%2Fdrug+therapy%22%5BMAJR%5D&sort=date&sort_order=desc"
|
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data-href="/?term=%22Arthralgia%2Fdrug+therapy%22%5BMAJR%5D&sort=date&sort_order=desc"
|
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Arthralgia/drug therapy"[MAJR]"
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Arthralgia"
|
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Search in MeSH
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</a></li><li><a class="add-to-search-link dropdown-block-link"
|
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Add to Search
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword Arthralgia / etiology"
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aria-expanded="false"
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data-pinger-ignore>
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Arthralgia / etiology
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</button><div id="keyword-actions-mesh-terms-8"
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class="keyword-actions-dropdown dropdown dropdown-container"
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hidden
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aria-label="Dropdown menu for keyword Arthralgia / etiology"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
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href="/?term=%22Arthralgia%2Fetiology%22%5BMeSH%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Arthralgia%2Fetiology%22%5BMeSH%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Arthralgia/etiology"[MeSH]"
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Arthralgia"
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Search in MeSH
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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data-search-term=""Arthralgia/etiology"[MeSH]"
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data-ga-category="search"
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data-ga-label=""Arthralgia/etiology"[MeSH]"
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword Humans"
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tabindex="0"
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aria-controls="keyword-actions-mesh-terms-9"
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aria-expanded="false"
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data-pinger-ignore>
|
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Humans
|
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</button><div id="keyword-actions-mesh-terms-9"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
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aria-label="Dropdown menu for keyword Humans"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
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href="/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Humans"[MeSH]"
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Humans"
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data-ga-category="search_mesh"
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Search in MeSH
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data-search-term=""Humans"[MeSH]"
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data-ga-category="search"
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data-ga-label=""Humans"[MeSH]"
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword Liver / drug effects"
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tabindex="0"
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aria-controls="keyword-actions-mesh-terms-10"
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aria-expanded="false"
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data-pinger-ignore>
|
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Liver / drug effects
|
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</button><div id="keyword-actions-mesh-terms-10"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
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aria-label="Dropdown menu for keyword Liver / drug effects"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
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href="/?term=%22Liver%2Fdrug+effects%22%5BMeSH%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Liver%2Fdrug+effects%22%5BMeSH%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Liver/drug effects"[MeSH]"
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data-ga-action="mesh_term"
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data-ga-label="Liver / drug effects">
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Liver"
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data-ga-category="search_mesh"
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Search in MeSH
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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data-search-term=""Liver/drug effects"[MeSH]"
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data-ga-category="search"
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data-ga-action="add_to_search"
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data-ga-label=""Liver/drug effects"[MeSH]"
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
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aria-label="Toggle dropdown menu for keyword Middle Aged"
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tabindex="0"
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aria-expanded="false"
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data-pinger-ignore>
|
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Middle Aged
|
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</button><div id="keyword-actions-mesh-terms-11"
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class="keyword-actions-dropdown dropdown dropdown-container"
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hidden
|
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aria-label="Dropdown menu for keyword Middle Aged"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
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href="/?term=%22Middle+Aged%22%5BMeSH%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Middle+Aged%22%5BMeSH%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Middle Aged"[MeSH]"
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Middle+Aged"
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data-ga-category="search_mesh"
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data-ga-action="mesh_term_link"
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data-ga-label="Middle Aged">
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Search in MeSH
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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data-search-term=""Middle Aged"[MeSH]"
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data-ga-category="search"
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data-ga-action="add_to_search"
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data-ga-label=""Middle Aged"[MeSH]"
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href="#">
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major"
|
||
aria-label="Toggle dropdown menu for keyword Osteoarthritis, Hip / drug therapy*"
|
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tabindex="0"
|
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aria-controls="keyword-actions-mesh-terms-major-12"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Osteoarthritis, Hip / drug therapy*
|
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</button><div id="keyword-actions-mesh-terms-major-12"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
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aria-label="Dropdown menu for keyword Osteoarthritis, Hip / drug therapy*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Osteoarthritis%2C+Hip%2Fdrug+therapy%22%5BMAJR%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22Osteoarthritis%2C+Hip%2Fdrug+therapy%22%5BMAJR%5D&sort=date&sort_order=desc"
|
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Osteoarthritis, Hip/drug therapy"[MAJR]"
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data-ga-category="search"
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data-ga-action="mesh_term"
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
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ref="linksrc=search_in_mesh_link"
|
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Osteoarthritis%2C+Hip"
|
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data-ga-category="search_mesh"
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data-ga-action="mesh_term_link"
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data-ga-label="Osteoarthritis, Hip / drug therapy*">
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Search in MeSH
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</a></li><li><a class="add-to-search-link dropdown-block-link"
|
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role="button"
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data-search-term=""Osteoarthritis, Hip/drug therapy"[MAJR]"
|
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data-ga-category="search"
|
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data-ga-action="add_to_search"
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data-ga-label=""Osteoarthritis, Hip/drug therapy"[MAJR]"
|
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href="#">
|
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major"
|
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aria-label="Toggle dropdown menu for keyword Osteoarthritis, Knee / drug therapy*"
|
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tabindex="0"
|
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aria-controls="keyword-actions-mesh-terms-major-13"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Osteoarthritis, Knee / drug therapy*
|
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</button><div id="keyword-actions-mesh-terms-major-13"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
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aria-label="Dropdown menu for keyword Osteoarthritis, Knee / drug therapy*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
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href="/?term=%22Osteoarthritis%2C+Knee%2Fdrug+therapy%22%5BMAJR%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22Osteoarthritis%2C+Knee%2Fdrug+therapy%22%5BMAJR%5D&sort=date&sort_order=desc"
|
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Osteoarthritis, Knee/drug therapy"[MAJR]"
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
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|
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Osteoarthritis%2C+Knee"
|
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data-ga-category="search_mesh"
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data-ga-label="Osteoarthritis, Knee / drug therapy*">
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Search in MeSH
|
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</a></li><li><a class="add-to-search-link dropdown-block-link"
|
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ref="linksrc=add_to_search_link"
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role="button"
|
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data-search-term=""Osteoarthritis, Knee/drug therapy"[MAJR]"
|
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data-ga-category="search"
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data-ga-action="add_to_search"
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data-ga-label=""Osteoarthritis, Knee/drug therapy"[MAJR]"
|
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href="#">
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword Pain Measurement"
|
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tabindex="0"
|
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aria-controls="keyword-actions-mesh-terms-14"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
||
Pain Measurement
|
||
</button><div id="keyword-actions-mesh-terms-14"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
||
aria-label="Dropdown menu for keyword Pain Measurement"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Pain+Measurement%22%5BMeSH%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22Pain+Measurement%22%5BMeSH%5D&sort=date&sort_order=desc"
|
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Pain Measurement"[MeSH]"
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data-ga-category="search"
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data-ga-action="mesh_term"
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data-ga-label="Pain Measurement">
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Search in PubMed
|
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
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ref="linksrc=search_in_mesh_link"
|
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Pain+Measurement"
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data-ga-category="search_mesh"
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data-ga-action="mesh_term_link"
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data-ga-label="Pain Measurement">
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Search in MeSH
|
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</a></li><li><a class="add-to-search-link dropdown-block-link"
|
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ref="linksrc=add_to_search_link"
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role="button"
|
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data-search-term=""Pain Measurement"[MeSH]"
|
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data-ga-category="search"
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data-ga-action="add_to_search"
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data-ga-label=""Pain Measurement"[MeSH]"
|
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href="#">
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
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aria-label="Toggle dropdown menu for keyword Randomized Controlled Trials as Topic"
|
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tabindex="0"
|
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aria-controls="keyword-actions-mesh-terms-15"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Randomized Controlled Trials as Topic
|
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</button><div id="keyword-actions-mesh-terms-15"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
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aria-label="Dropdown menu for keyword Randomized Controlled Trials as Topic"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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href="/?term=%22Randomized+Controlled+Trials+as+Topic%22%5BMeSH%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Randomized+Controlled+Trials+as+Topic%22%5BMeSH%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Randomized Controlled Trials as Topic"[MeSH]"
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data-ga-category="search"
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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Search in MeSH
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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role="button"
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data-search-term=""Randomized Controlled Trials as Topic"[MeSH]"
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data-ga-category="search"
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data-ga-action="add_to_search"
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href="#">
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Add to Search
|
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</a></li></ul></div></div></div></li></ul>
|
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</div>
|
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|
||
|
||
|
||
|
||
|
||
<div id="substances" class="substances keywords-section">
|
||
<h2 class="title">
|
||
Substances
|
||
</h2>
|
||
|
||
<ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword Analgesics, Non-Narcotic"
|
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tabindex="0"
|
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aria-controls="keyword-actions-substances-0"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Analgesics, Non-Narcotic
|
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</button><div id="keyword-actions-substances-0"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
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hidden
|
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aria-label="Dropdown menu for keyword Analgesics, Non-Narcotic"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
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href="/?term=%22Analgesics%2C+Non-Narcotic%22%5Bnm%5D&sort=date&sort_order=desc"
|
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data-href="/?term=%22Analgesics%2C+Non-Narcotic%22%5Bnm%5D&sort=date&sort_order=desc"
|
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ref="linksrc=search_in_pubmed_keyword_link&keyword="Analgesics, Non-Narcotic"[nm]"
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data-ga-category="search"
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data-ga-action="substance"
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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ref="linksrc=search_in_mesh_link"
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href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Analgesics%2C+Non-Narcotic%22"
|
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data-ga-action="substance_link"
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Search in MeSH
|
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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ref="linksrc=add_to_search_link"
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role="button"
|
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data-search-term=""Analgesics, Non-Narcotic"[nm]"
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data-ga-category="search"
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data-ga-action="add_to_search"
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data-ga-label=""Analgesics, Non-Narcotic"[nm]"
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
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aria-label="Toggle dropdown menu for keyword Acetaminophen"
|
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tabindex="0"
|
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aria-controls="keyword-actions-substances-1"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Acetaminophen
|
||
</button><div id="keyword-actions-substances-1"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
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aria-label="Dropdown menu for keyword Acetaminophen"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
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