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<meta name="description" content="Once-daily oral administration of BCX7353 at a dose of 125 mg or more resulted in a significantly lower rate of attacks of hereditary angioedema than placebo. Mild gastrointestinal symptoms were the principal side effect. (Funded by BioCryst Pharmaceuticals; APeX-1 ClinicalTrials.gov number, NCT0287 …"><meta name="keywords" content="pmid:30044938, doi:10.1056/NEJMoa1716995, Clinical Trial, Phase II, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov&#x27;t, Emel Aygören-Pürsün, Anette Bygum, Marco Cicardi, Administration, Oral, Adult, Aged, Angioedemas, Hereditary / prevention &amp; control*, Dose-Response Relationship, Drug, Double-Blind Method, Drug Administration Schedule, Enzyme Inhibitors / administration &amp; dosage*, Enzyme Inhibitors / adverse effects, Enzyme Inhibitors / pharmacokinetics, Female, Humans, Male, Middle Aged, Plasma Kallikrein / antagonists &amp; inhibitors*, Quality of Life, PubMed Abstract, NIH, NLM, NCBI, National Institutes of Health, National Center for Biotechnology Information, National Library of Medicine, MEDLINE"><meta name="robots" content="index,nofollow,noarchive"><meta property="og:title" content="Oral Plasma Kallikrein Inhibitor for Prophylaxis in Hereditary Angioedema - PubMed"><meta property="og:url" content="https://pubmed.ncbi.nlm.nih.gov/30044938/"><meta property="og:description" content="Once-daily oral administration of BCX7353 at a dose of 125 mg or more resulted in a significantly lower rate of attacks of hereditary angioedema than placebo. Mild gastrointestinal symptoms were the principal side effect. (Funded by BioCryst Pharmaceuticals; APeX-1 ClinicalTrials.gov number, NCT0287 …"><meta property="og:image" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg"><meta property="og:image:secure_url" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg"><meta property="og:type" content="website"><meta property="og:site_name" content="PubMed"><meta name="twitter:domain" content="pubmed.ncbi.nlm.nih.gov"><meta name="twitter:card" content="summary_large_image"><meta name="twitter:title" content="Oral Plasma Kallikrein Inhibitor for Prophylaxis in Hereditary Angioedema - PubMed"><meta name="twitter:url" content="https://pubmed.ncbi.nlm.nih.gov/30044938/"><meta name="twitter:description" content="Once-daily oral administration of BCX7353 at a dose of 125 mg or more resulted in a significantly lower rate of attacks of hereditary angioedema than placebo. Mild gastrointestinal symptoms were the principal side effect. (Funded by BioCryst Pharmaceuticals; APeX-1 ClinicalTrials.gov number, NCT0287 …"><meta name="twitter:image" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg">
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<input type="email" aria-label="Recipient Email Address" placeholder="email@example.com" id="email-to" class="email-to" pattern="^[a-zA-Z0-9_.+-]+@[a-zA-Z0-9-]+\.[a-zA-Z0-9-.]+$" maxlength="100" required>
</div>
<div class="action-panel-control-wrap">
<label for="email-from" class="action-panel-label">
From:
</label>
<input type="email" aria-label="Sender Email Address" placeholder="email@example.com" id="email-from" class="email-from" pattern="^[a-zA-Z0-9_.+-]+@[a-zA-Z0-9-]+\.[a-zA-Z0-9-.]+$" maxlength="256">
</div>
<div class="action-panel-control-wrap">
<label for="email-citation-format" class="action-panel-label">
Format:
</label>
<select id="email-citation-format" name="citation-format" class="action-panel-selector email-citation-format">
<option selected="selected" value="summary">Summary</option>
<option value="summary-text">Summary (text)</option>
<option value="abstract">Abstract</option>
<option value="abstract-text">Abstract (text)</option>
</select>
</div>
<div class="include-supplemental-container">
<input type="checkbox" aria-label="Include MeSH and other data" name="include-supplemental" id="email-include-supplemental" class="email-include-supplemental">
<label for="email-include-supplemental" class="email-include-supplemental-label">MeSH and other data</label>
</div>
<div class="form-field recaptcha ">
<div class="g-recaptcha" id="id-recaptcha" data-sitekey="6LfsWHMdAAAAAClKbtOpjQ2pMjgsGxvv7NdZW9uI"></div>
</div>
<div id="captcha-error-message" class="usa-input-error-message captcha-validation-message" role="alert"></div>
<div class="action-panel-actions">
<button class="action-panel-submit"
type="submit"
data-loading-label="Sending..."
data-ga-category="save_share"
data-ga-action="email"
data-ga-label="send">
Send email
</button>
<button class="action-panel-cancel"
aria-label="Close 'Email citations' panel"
ref="linksrc=close_email_panel"
aria-controls="email-action-panel"
aria-expanded="false"
data-ga-category="save_share"
data-ga-action="email"
data-ga-label="cancel">
Cancel
</button>
</div>
<input type="hidden" name="email-search-details" value="" />
<input type="hidden" name="email-search-details-hash" value="0e42663a6c3bd85498fcb88798998fed7bfdc45d457db35281e41afe13cc0524" />
</form>
</div>
</div>
<div id="collections-action-panel"
class="collections-action-panel action-panel in-progress-dots-panel"
aria-hidden="true"
data-collections-open-panel-enabled="false"
data-collections-open-panel-url-hash="#open-collections-panel">
<div class="inner-wrap">
<h3 class="action-panel-heading">
Add to Collections
</h3>
<form id="collections-action-panel-form"
class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
data-existing-collections-url="/list-existing-collections/"
data-add-to-existing-collection-url="/add-to-existing-collection/"
data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/"
data-get-article-ids-by-search-url="/get-article-ids-by-search/"
data-myncbi-max-collection-name-length="100"
data-add-to-collection-max-amount="1000"
data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/">
<input type="hidden" name="csrfmiddlewaretoken" value="FDAHM6DVrZNO2Jm0qjQs28sQ0E43tW8XWqkMpW6h1AAiWasQ3CtuwgYuyIMfmxGh">
<div class="choice-group" role="radiogroup">
<ul class="radio-group-items">
<li>
<input type="radio"
id="collections-action-panel-new"
class="collections-new"
name="collections"
value="new"
data-ga-category="save_share"
data-ga-action="collections"
data-ga-label="collections_radio_new">
<label for="collections-action-panel-new">Create a new collection</label>
</li>
<li>
<input type="radio"
id="collections-action-panel-existing"
class="collections-existing"
name="collections"
value="existing"
checked="true"
data-ga-category="save_share"
data-ga-action="collections"
data-ga-label="collections_radio_existing">
<label for="collections-action-panel-existing">Add to an existing collection</label>
</li>
</ul>
</div>
<div class="controls-wrapper">
<div class="action-panel-control-wrap new-collections-controls">
<label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk">
Name your collection:
</label>
<input
type="text"
name="add-to-new-collection"
id="collections-action-panel-add-to-new"
class="collections-action-add-to-new"
pattern="[^&quot;&amp;=&lt;&gt;\/]*" title="The following characters are not allowed in the Name field: &quot;&amp;=&lt;&gt;/"
maxlength="100"
data-ga-category="save_share"
data-ga-action="create_collection"
data-ga-label="non_favorties_collection">
<div class="collections-new-name-too-long usa-input-error-message selection-validation-message">
Name must be less than 100 characters
</div>
</div>
<div class="action-panel-control-wrap existing-collections-controls">
<label for="collections-action-panel-add-to-existing" class="action-panel-label">
Choose a collection:
</label>
<select id="collections-action-panel-add-to-existing"
class="action-panel-selector collections-action-add-to-existing"
data-ga-category="save_share"
data-ga-action="select_collection"
data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'">
</select>
<div class="collections-retry-load-on-error usa-input-error-message selection-validation-message">
Unable to load your collection due to an error<br>
<a href="#">Please try again</a>
</div>
</div>
</div>
<div class="action-panel-actions">
<button class="action-panel-submit"
type="submit"
data-loading-label="Adding..."
data-pinger-ignore
data-ga-category="save_share"
data-ga-action="collections"
data-ga-label="add">
Add
</button>
<button class="action-panel-cancel"
aria-label="Close 'Add to Collections' panel"
ref="linksrc=close_collections_panel"
aria-controls="collections-action-panel"
aria-expanded="false"
data-ga-category="save_share"
data-ga-action="collections"
data-ga-label="cancel">
Cancel
</button>
</div>
</form>
</div>
</div>
<div id="bibliography-action-panel"
class="bibliography-action-panel action-panel in-progress-dots-panel"
aria-hidden="true"
data-bibliography-open-panel-enabled="false"
data-bibliography-open-panel-url-hash="#open-bibliography-panel">
<div class="inner-wrap">
<h3 class="action-panel-heading">
Add to My Bibliography
</h3>
<form id="bibliography-action-panel-form"
class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
data-add-to-bibliography-max-amount="100"
data-add-to-bibliography-batch-size="10"
data-bibliography-delegates-url="/list-bibliography-delegates/"
data-add-to-bibliography-url="/add-to-bibliography/"
data-get-article-ids-by-search-url="/get-article-ids-by-search/"
data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/">
<input type="hidden" name="csrfmiddlewaretoken" value="FDAHM6DVrZNO2Jm0qjQs28sQ0E43tW8XWqkMpW6h1AAiWasQ3CtuwgYuyIMfmxGh">
<div class="action-panel-control-wrap bibliographies-controls">
<div class="choice-group">
<ul class="bibliographies-action-add radio-group-items">
<li>
<input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/>
<label for="my-bibliography">My Bibliography</label>
</li>
</ul>
</div>
</div>
<div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message">
Unable to load your delegates due to an error<br>
<a href="#">Please try again</a>
</div>
<div class="action-panel-actions">
<button class="action-panel-submit"
type="submit"
data-loading-label="Adding..."
data-pinger-ignore>
Add
</button>
<button class="action-panel-cancel"
aria-label="Close 'Add to bibliography' panel"
ref="linksrc=close_bibliography_panel"
aria-controls="bibliography-action-panel"
aria-expanded="false"
data-ga-category="save_share"
data-ga-action="mybib"
data-ga-label="cancel">
Cancel
</button>
</div>
</form>
</div>
</div>
<div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true"
data-saved-search-open-panel-enabled="false"
data-saved-search-open-panel-url-hash="#open-saved-search-panel">
<div class="inner-wrap">
<h2 class="action-panel-heading">
Your saved search
</h2>
<form id="saved-search-action-panel-form"
class="saved-search-action-panel-form action-panel-content action-form"
data-create-saved-search-url="/create-saved-search/"
data-try-search-terms-url="/try-search-term/"
data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/">
<input type="hidden" name="csrfmiddlewaretoken" value="FDAHM6DVrZNO2Jm0qjQs28sQ0E43tW8XWqkMpW6h1AAiWasQ3CtuwgYuyIMfmxGh">
<div class="action-panel-control-wrap">
<label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk">
Name of saved search:
</label>
<input maxlength="200"
type="text"
name="saved-search-name"
id="saved-search-name"
class="saved-search-name"
value=""
required
pattern="[^&quot;&amp;=&lt;&gt;\/]*" title="The following characters are not allowed in the Name field: &quot;&amp;=&lt;&gt;/">
</div>
<div class="action-panel-control-wrap">
<label for="saved-search-term" class="action-panel-label required-field-asterisk">
Search terms:
</label>
<textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea>
</div>
<div class="test-search-term-wrap">
<a href="#" class="try-search-term">Test search terms</a>
</div>
<div class="choice-group action-panel-extra-margin-top">
<span class="action-panel-label" id="fieldset-label">
Would you like email updates of new search results?
</span>
<fieldset id="saved-search-alert" aria-describedby="fieldset-label">
<legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend>
<ul class="radio-group-items">
<li>
<input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked>
<label for="saved-search-alert-yes" class="action-panel-label">Yes</label>
</li>
<li>
<input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no">
<label for="saved-search-alert-no" class="action-panel-label">No</label>
</li>
</ul>
</fieldset>
</div>
<div class="alert-schedule-wrap">
<div class="action-panel-control-wrap">
<label class="action-panel-label">
Email:
</label>
<span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span>
</div>
<div class="action-panel-control-wrap action-panel-extra-margin-top">
<label for="saved-search-frequency" class="action-panel-label">
Frequency:
</label>
<select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency">
<option value="monthly">Monthly</option>
<option value="weekly">Weekly</option>
<option value="daily">Daily</option>
</select>
</div>
<div class="action-panel-control-wrap saved-search-monthly-additional">
<label for="saved-search-monthly-on-day" class="action-panel-label">
Which day?
</label>
<select id="saved-search-monthly-on-day" class="no-border-panel-selector">
<option value="Sunday">The first Sunday</option>
<option value="Monday">The first Monday</option>
<option value="Tuesday">The first Tuesday</option>
<option value="Wednesday">The first Wednesday</option>
<option value="Thursday">The first Thursday</option>
<option value="Friday">The first Friday</option>
<option value="Saturday">The first Saturday</option>
<option value="day">The first day</option>
<option value="weekday">The first weekday</option>
</select>
</div>
<div class="action-panel-control-wrap saved-search-weekly-additional">
<label for="saved-search-weekly-on-day" class="action-panel-label">
Which day?
</label>
<select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day">
<option value="Sunday">Sunday</option>
<option value="Monday">Monday</option>
<option value="Tuesday">Tuesday</option>
<option value="Wednesday">Wednesday</option>
<option value="Thursday">Thursday</option>
<option value="Friday">Friday</option>
<option value="Saturday">Saturday</option>
</select>
</div>
<div class="action-panel-control-wrap">
<label for="saved-search-report" class="action-panel-label">
Report format:
</label>
<select id="saved-search-report" class="no-border-panel-selector saved-search-report">
<option value="DocSum">Summary</option>
<option value="DocSumText">Summary (text)</option>
<option value="Abstract">Abstract</option>
<option value="AbstractText">Abstract (text)</option>
<option value="MEDLINE">PubMed</option>
</select>
</div>
<div class="action-panel-control-wrap">
<label for="saved-search-amount" class="action-panel-label">
Send at most:
</label>
<select id="saved-search-amount" class="no-border-panel-selector saved-search-amount">
<option value="1">1 item</option>
<option value="5" selected>5 items</option>
<option value="10">10 items</option>
<option value="20">20 items</option>
<option value="50">50 items</option>
<option value="100">100 items</option>
<option value="200">200 items</option>
</select>
</div>
<div>
<input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result">
<label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox">
Send even when there aren't any new results
</label>
</div>
<div class="action-panel-control-wrap option-text-in-email-wrap">
<label for="saved-search-email-text" class="action-panel-label">
Optional text in email:
</label>
<textarea name="saved-search-email-text"
id="saved-search-email-text"
class="saved-search-email-text"></textarea>
</div>
</div>
<div class="action-panel-actions">
<button class="action-panel-submit"
type="submit"
data-loading-label="Saving..."
data-ga-category="save_share"
data-ga-action="alert"
data-ga-label="save">
Save
</button>
<button class="action-panel-cancel"
aria-label="Close 'Your saved search' panel"
ref="linksrc=close_saved_search_panel"
aria-controls="saved-search-action-panel"
aria-expanded="false"
data-ga-category="save_share"
data-ga-action="alert"
data-ga-label="cancel">
Cancel
</button>
</div>
</form>
</div>
</div>
<div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true">
<div class="inner-wrap">
<h2 class="action-panel-heading">
Create a file for external citation management software
</h2>
<form id="citation-manager-action-panel-form"
class="action-panel-content action-form"
action="/results-export-ids/"
data-by-search-action="/results-export-search-data/"
data-by-ids-action="/results-export-ids/"
method="post"
data-by-search-method="post"
data-by-ids-method="post">
<input type="hidden" name="csrfmiddlewaretoken" value="FDAHM6DVrZNO2Jm0qjQs28sQ0E43tW8XWqkMpW6h1AAiWasQ3CtuwgYuyIMfmxGh">
<input name="results-format" type="hidden" value="pubmed"/>
<div class="action-panel-actions">
<button class="action-panel-submit"
type="submit"
data-loading-label="Sending..."
data-ga-category="save_share"
data-ga-action="citation_manager"
data-ga-label="save">
Create file
</button>
<button class="action-panel-cancel"
aria-label="Close 'Send citations to citation manager' panel"
ref="linksrc=close_citation_manager_panel"
aria-controls="citation-manager-action-panel"
aria-expanded="false"
data-ga-category="save_share"
data-ga-action="citation_manager"
data-ga-label="cancel">
Cancel
</button>
</div>
</form>
</div>
</div>
<div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true">
<div class="inner-wrap">
<h2 class="action-panel-heading">
Your RSS Feed
</h2>
<form id="rss-action-panel-form"
class="rss-action-panel-form action-panel-content action-form"
data-create-rss-feed-url="/create-rss-feed-url/"
data-search-form-term-value="">
<input type="hidden" name="csrfmiddlewaretoken" value="FDAHM6DVrZNO2Jm0qjQs28sQ0E43tW8XWqkMpW6h1AAiWasQ3CtuwgYuyIMfmxGh">
<div class="action-panel-control-wrap">
<label for="rss-name" class="action-panel-label required-field-asterisk">
Name of RSS Feed:
</label>
<input maxlength="200"
placeholder="Name"
type="text"
name="rss-name"
id="rss-name"
class="rss-name"
value=''
required
pattern="[^&quot;&amp;=&lt;&gt;\/]*" title="The following characters are not allowed in the Name field: &quot;&amp;=&lt;&gt;/">
</div>
<div class="rss-limit-wrap">
<div class="action-panel-control-wrap action-panel-extra-margin-top">
<label for="rss-limit" class="action-panel-label">
Number of items displayed:
</label>
<select id="rss-limit" class="no-border-panel-selector rss-limit">
<option value="5">5</option>
<option value="10">10</option>
<option value="15" selected="selected">15</option>
<option value="20">20</option>
<option value="50">50</option>
<option value="100">100</option>
</select>
</div>
</div>
<div class="action-panel-actions">
<button class="action-panel-submit"
type="submit"
data-loading-label="Creating..."
data-ga-category="save_share"
data-ga-action="alert"
data-ga-label="save">
Create RSS
</button>
<button class="action-panel-cancel"
aria-label="Close 'Your RSS' panel"
ref="linksrc=close_rss_panel"
aria-controls="rss-action-panel"
aria-expanded="false"
data-ga-category="save_share"
data-ga-action="alert"
data-ga-label="cancel">
Cancel
</button>
</div>
<div class="action-panel-control-wrap rss-link-copy-wrap">
<label for="rss-link" class="usa-sr-only">RSS Link</label>
<input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link">
<button
type="button"
disabled
class="rss-link-copy-button disabled"
data-ga-category="save_share"
data-ga-action="rss"
data-ga-label="copy">
Copy
</button>
</div>
</form>
</div>
</div>
</div>
</div>
<div class="article-page" id="article-page" data-article-pmid="30044938">
<aside class="page-sidebar">
<div class="inner-wrap">
<div class="full-text-links">
<div class="full-view">
<h3 class="title">
Full text links
</h3>
<div class="full-text-links-list">
<a class="link-item
dialog-focus"
href="https://www.nejm.org/doi/10.1056/NEJMoa1716995?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub 0www.ncbi.nlm.nih.gov"
target="_blank"
rel="noopener"
ref="linksrc=fulltextorjournal_fulltext&amp;is_pmc=False&amp;PrId=4487&amp;itool=Abstract-def&amp;log$=linkouticon&amp;uid=30044938&amp;db=pubmed&amp;nlmid=0255562"
title="See full text options at Atypon"
data-ga-category="full_text"
data-ga-action="Atypon"
data-ga-label="30044938"
><img src="https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--www.nejm.org-pb-assets-images-editorial-icons-nejm-free-full-text.gif" alt="Atypon full text link"><span class="text">
Atypon
</span></a>
</div>
</div>
<div class="short-view">
<a href="#" class="full-text-links-button full-text-links-dialog-trigger">
Full text links
</a>
</div>
</div>
<div class="actions-buttons sidebar"><h3 class="title">Actions</h3><div class="inner-wrap"><button class="citation-button citation-dialog-trigger"
aria-label="Open dialog with citation text in different styles"
data-ga-category="save_share"
data-ga-action="cite"
data-ga-label="open"
data-all-citations-url="/30044938/citations/"
data-citation-style="nlm"
data-pubmed-format-link="/30044938/export/"><span class="button-label">Cite</span></button><link type="text/css" href="ncbi-overlay-block/src/overlay-block.css"><div class="collections-button-container" data-article-id="30044938" data-article-db="pubmed"><button class="collections-button collections-dialog-trigger"
aria-label="Save article in MyNCBI collections."
data-ga-category="collections_button"
data-ga-action="click"
data-ga-label="collections_button"
data-collections-open-dialog-enabled="false"
data-collections-open-dialog-url="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F30044938%2F%23open-collections-dialog"
data-in-collections="false"><span class="button-label">Collections</span></button><div class="overlay" role="dialog"><div id="collections-action-dialog"
class="dialog collections-dialog"
aria-hidden="true"><div class="title">Add to Collections</div><div class="collections-action-panel action-panel"><form id="collections-action-dialog-form"
class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
data-existing-collections-url="/list-existing-collections/"
data-add-to-existing-collection-url="/add-to-existing-collection/"
data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/"
data-myncbi-max-collection-name-length="100"
data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"><input type="hidden" name="csrfmiddlewaretoken" value="FDAHM6DVrZNO2Jm0qjQs28sQ0E43tW8XWqkMpW6h1AAiWasQ3CtuwgYuyIMfmxGh"><div class="choice-group" role="radiogroup"><ul class="radio-group-items"><li><input type="radio"
id="collections-action-dialog-new"
class="collections-new"
name="collections"
value="new"
data-ga-category="collections_button"
data-ga-action="click"
data-ga-label="collections_radio_new"><label for="collections-action-dialog-new">Create a new collection</label></li><li><input type="radio"
id="collections-action-dialog-existing"
class="collections-existing"
name="collections"
value="existing"
checked="true"
data-ga-category="collections_button"
data-ga-action="click"
data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li></ul></div><div class="controls-wrapper"><div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk">
Name your collection:
</label><input
type="text"
name="add-to-new-collection"
id="collections-action-dialog-add-to-new"
class="collections-action-add-to-new"
pattern="[^&quot;&amp;=&lt;&gt;\/]*" title="The following characters are not allowed in the Name field: &quot;&amp;=&lt;&gt;/"
maxlength="100"
data-ga-category="collections_button"
data-ga-action="create_collection"
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<h1 class="heading-title">
Oral Plasma Kallikrein Inhibitor for Prophylaxis in Hereditary Angioedema
</h1>
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<span class="authors-list-item "><a class="full-name"
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data-ga-label="Emel Aygören-Pürsün">Emel Aygören-Pürsün</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Anette Bygum">Anette Bygum</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Urs C Steiner">Urs C Steiner</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Fain+O&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
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data-ga-label="Olivier Fain">Olivier Fain</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Huissoon+A&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
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data-ga-label="Aarnoud Huissoon">Aarnoud Huissoon</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Kinaciyan+T&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Tamar Kinaciyan">Tamar Kinaciyan</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Farkas+H&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
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data-ga-action="author_link"
data-ga-label="Henriette Farkas">Henriette Farkas</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Lleonart+R&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
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data-ga-action="author_link"
data-ga-label="Ramon Lleonart">Ramon Lleonart</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Longhurst+HJ&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
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data-ga-action="author_link"
data-ga-label="Hilary J Longhurst">Hilary J Longhurst</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Rae+W&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
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data-ga-action="author_link"
data-ga-label="William Rae">William Rae</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Triggiani+M&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
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data-ga-action="author_link"
data-ga-label="Massimo Triggiani">Massimo Triggiani</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Aberer+W&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
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data-ga-label="Werner Aberer">Werner Aberer</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Cancian+M&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
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data-ga-label="Mauro Cancian">Mauro Cancian</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Zanichelli+A&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Andrea Zanichelli">Andrea Zanichelli</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Smith+WB&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
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data-ga-action="author_link"
data-ga-label="William B Smith">William B Smith</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Baeza+ML&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
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data-ga-action="author_link"
data-ga-label="Maria L Baeza">Maria L Baeza</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Du-Thanh+A&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Aurelie Du-Thanh">Aurelie Du-Thanh</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Gompels+M&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
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data-ga-action="author_link"
data-ga-label="Mark Gompels">Mark Gompels</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Gonzalez-Quevedo+T&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Teresa Gonzalez-Quevedo">Teresa Gonzalez-Quevedo</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Greve+J&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
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data-ga-action="author_link"
data-ga-label="Jens Greve">Jens Greve</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Guilarte+M&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
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data-ga-action="author_link"
data-ga-label="Mar Guilarte">Mar Guilarte</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Katelaris+C&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Constance Katelaris">Constance Katelaris</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Dobo+S&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Sylvia Dobo">Sylvia Dobo</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Cornpropst+M&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Melanie Cornpropst">Melanie Cornpropst</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Clemons+D&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Desiree Clemons">Desiree Clemons</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Fang+L&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Lei Fang">Lei Fang</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Collis+P&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
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data-ga-label="Phil Collis">Phil Collis</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
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data-ga-label="William Sheridan">William Sheridan</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
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data-ga-label="Marcus Maurer">Marcus Maurer</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#full-view-affiliation-1" ref="linksrc=author_aff">
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><sup class="key">1</sup> From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC.</li>
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Oral Plasma Kallikrein Inhibitor for Prophylaxis in Hereditary Angioedema
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<span class="authors-list-item "><span class="full-name">Emel Aygören-Pürsün</span><span class="citation-separator">&nbsp;et al.</span></span>
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data-ga-label="Emel Aygören-Pürsün">Emel Aygören-Pürsün</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
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data-ga-label="Anette Bygum">Anette Bygum</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Grivcheva-Panovska+V&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
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data-ga-action="author_link"
data-ga-label="Vesna Grivcheva-Panovska">Vesna Grivcheva-Panovska</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Magerl+M&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
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data-ga-action="author_link"
data-ga-label="Markus Magerl">Markus Magerl</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Graff+J&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Jochen Graff">Jochen Graff</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Steiner+UC&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Urs C Steiner">Urs C Steiner</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Fain+O&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Olivier Fain">Olivier Fain</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Huissoon+A&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Aarnoud Huissoon">Aarnoud Huissoon</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Kinaciyan+T&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Tamar Kinaciyan">Tamar Kinaciyan</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Farkas+H&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Henriette Farkas">Henriette Farkas</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Lleonart+R&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Ramon Lleonart">Ramon Lleonart</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Longhurst+HJ&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
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data-ga-action="author_link"
data-ga-label="Hilary J Longhurst">Hilary J Longhurst</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Rae+W&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="William Rae">William Rae</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Triggiani+M&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Massimo Triggiani">Massimo Triggiani</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Aberer+W&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Werner Aberer">Werner Aberer</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Cancian+M&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Mauro Cancian">Mauro Cancian</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Zanichelli+A&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Andrea Zanichelli">Andrea Zanichelli</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Smith+WB&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="William B Smith">William B Smith</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Baeza+ML&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Maria L Baeza">Maria L Baeza</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Du-Thanh+A&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Aurelie Du-Thanh">Aurelie Du-Thanh</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Gompels+M&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Mark Gompels">Mark Gompels</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Gonzalez-Quevedo+T&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Teresa Gonzalez-Quevedo">Teresa Gonzalez-Quevedo</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Greve+J&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Jens Greve">Jens Greve</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Guilarte+M&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Mar Guilarte">Mar Guilarte</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Katelaris+C&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Constance Katelaris">Constance Katelaris</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Dobo+S&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Sylvia Dobo">Sylvia Dobo</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Cornpropst+M&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Melanie Cornpropst">Melanie Cornpropst</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Clemons+D&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Desiree Clemons">Desiree Clemons</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Fang+L&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Lei Fang">Lei Fang</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Collis+P&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Phil Collis">Phil Collis</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Sheridan+W&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="William Sheridan">William Sheridan</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Maurer+M&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Marcus Maurer">Marcus Maurer</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup><span class="comma">,&nbsp;</span></span><span class="authors-list-item "><a class="full-name"
href="/?term=Cicardi+M&amp;cauthor_id=30044938"
ref="linksrc=author_name_link"
data-ga-category="search"
data-ga-action="author_link"
data-ga-label="Marco Cicardi">Marco Cicardi</a><sup class="affiliation-links"><span class="author-sup-separator">&nbsp;</span><a class="affiliation-link" title="From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC." href="#short-view-affiliation-1" ref="linksrc=author_aff">
1
</a></sup></span>
</div>
</div>
<div class="affiliations">
<h3 class="title">
Affiliation
</h3>
<ul class="item-list">
<li data-affiliation-id="short-view-affiliation-1"
id="short-view-affiliation-1"
><sup class="key">1</sup> From the Division of Hematology, Oncology, and Hemostaseology, Department of Children and Adolescents, Angioedema Center, University Hospital Frankfurt (E.A.-P.), and the Fraunhofer Institute for Molecular Biology and Applied Ecology, Translational Medicine and Pharmacology (J. Graff), Frankfurt, the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Magerl, M. Maurer), and the Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm (J. Greve) - all in Germany; the Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark (A.B.); Public Health Institution University Clinic of Dermatology, School of Medicine, University Sts. Cyril and Methodius, Skopje, Macedonia (V.G.-P.); the Department of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland (U.C.S.); Assistance Publique-Hôpitaux de Paris Hôpital Saint Antoine, Sorbonne Université, Paris (O.F.), and the Department of Dermatology, Université de Montpellier, Montpellier (A.D.-T.) - both in France; the Allergy and Immunology West Midlands, Birmingham Heartlands Hospital, Birmingham (A.H.), Barts Health NHS Trust-Royal London Hospital, London (H.J.L.), the National Institute for Health Research Southampton Clinical Research Facility, Southampton (W.R.), and the North Bristol NHS Trust, Southmead Hospital, Bristol (M. Gompels) - all in the United Kingdom; the Department of Dermatology, Medical University of Vienna, Vienna (T.K.), and the Department of Dermatology and Venereology, Medical University of Graz, Graz (W.A.) - both in Austria; the Hungarian Angioedema Reference Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary (H.F.); the Allergology Unit, Department of Internal Medicine, Hospital Universitario Bellvitge de L&#x27;Hospitalet de Llobregat (R.L.) and Hospital Universitari Vall d&#x27;Hebron, Vall d&#x27;Hebron Research Institute (M. Guilarte), Barcelona, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras)-Unit 761, Institute for Health Research, Gregorio Marañon, Madrid (M.L.B.), and Hospital Universitario Virgen del Rocío, Seville (T.G.-Q.) - all in Spain; the Division of Allergy and Clinical Immunology, University of Salerno, Salerno (M.T.), the Department of Medicine, University of Padua, Padua (M. Cancian), and Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco-Università degli Studi di Milano, Milan (A.Z., M. Cicardi) - all in Italy; the Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA (W.B.S.), and Campbelltown Hospital, Immunology and Allergy, Western Sydney University, Sydney (C.K.) - both in Australia; and BioCryst Pharmaceuticals (S.D., M. Cornpropst, D.C., P.C., W.S.) and PharStat (L.F.) - both in Durham, NC.</li>
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Background:
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Hereditary angioedema is a life-threatening illness caused by mutations in the gene encoding C1 inhibitor (also called C1 esterase inhibitor) that lead to overactivation of the kallikrein-bradykinin cascade. BCX7353 is a potent oral small-molecule inhibitor of plasma kallikrein with a pharmacokinetic and pharmacodynamic profile that may help prevent angioedema attacks.
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In this international, three-part, dose-ranging, placebo-controlled trial, we evaluated four doses of BCX7353 (62.5 mg, 125 mg, 250 mg, and 350 mg once daily) for the prevention of angioedema attacks over a 28-day period. Patients with type I or II hereditary angioedema with a history of at least two angioedema attacks per month were randomly assigned to BCX7353 or placebo. The primary efficacy end point was the number of confirmed angioedema attacks. Key secondary end points included angioedema attacks according to anatomical location and quality of life.
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A total of 77 patients underwent randomization, 75 received BCX7353 or placebo, and 72 completed the trial. The rate of confirmed angioedema attacks was significantly lower among patients who received BCX7353 at daily doses of 125 mg or more than among those who received placebo, with a 73.8% difference at 125 mg (P&lt;0.001). Significant benefits with respect to quality-of-life scores were observed in the 125-mg and 250-mg dose groups (P&lt;0.05). Gastrointestinal adverse events, predominantly of grade 1, were the most commonly reported adverse events, particularly in the two highest BCX7353 dose groups.
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Once-daily oral administration of BCX7353 at a dose of 125 mg or more resulted in a significantly lower rate of attacks of hereditary angioedema than placebo. Mild gastrointestinal symptoms were the principal side effect. (Funded by BioCryst Pharmaceuticals; APeX-1 ClinicalTrials.gov number, <a href="http://clinicaltrials.gov/show/NCT02870972" title="See in ClinicalTrials.gov">NCT02870972</a> .).
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