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||
id="id_term"/><a href="#" class="clear-btn" aria-label="Clear search input" title="Clear search input" role="button" data-pinger-ignore></a><button type="submit" class="search-btn" aria-label="Search" disabled data-pinger-ignore><span class="usa-search-submit-text">Search</span></button>
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<!-- Create alert and Create RSS are buttons that look like links -->
|
||
<!-- Better for them to look like buttons but no space -->
|
||
<div class="search-links-wrapper content-page-layout">
|
||
<div class="search-links">
|
||
<a href="/advanced/"
|
||
class="search-input-link adv-search-link"
|
||
data-ga-category="featured_link"
|
||
data-ga-action="adv_search">Advanced</a>
|
||
|
||
|
||
<a href="/clipboard/"
|
||
class="search-input-link clipboard-link hidden"
|
||
data-ga-category="featured_link"
|
||
data-ga-action="clipboard">
|
||
Clipboard <span class="amount-in-clipboard"></span>
|
||
</a>
|
||
</div>
|
||
|
||
<span class="search-input-link user-guide-link" role="navigation" aria-label="User guide">
|
||
<a href="/help/"
|
||
data-ga-category="featured_link"
|
||
data-ga-action="user_guide">
|
||
User Guide
|
||
</a>
|
||
</span>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
</form>
|
||
|
||
|
||
<div id="article-page-header">
|
||
<div id="article-top-actions-bar" class="article-top-actions-bar">
|
||
<div class="inner-wrap">
|
||
<div class="actions-container">
|
||
<div class="return-to-search">
|
||
|
||
|
||
</div>
|
||
|
||
<div class="multiple-results-actions " role="region" aria-label="save, email, send to">
|
||
<button id="save-results-panel-trigger"
|
||
type="button"
|
||
class="save-results save-results-panel-trigger"
|
||
aria-expanded="false"
|
||
aria-controls="save-action-panel"
|
||
data-ga-category="save_share"
|
||
data-ga-action="save"
|
||
data-ga-label="open">
|
||
Save
|
||
</button><button id="email-results-panel-trigger"
|
||
type="button"
|
||
class="email-results email-results-panel-trigger"
|
||
aria-expanded="false"
|
||
aria-controls="email-action-panel"
|
||
data-ga-category="save_share"
|
||
data-ga-action="email"
|
||
data-ga-label="open">
|
||
Email
|
||
</button><div class="more-actions dropdown-block"><button id="more-actions-trigger"
|
||
type="button"
|
||
class="trigger more-actions-trigger"
|
||
ref="linksrc=show_moreactions_btn"
|
||
aria-label="Send to"
|
||
aria-controls="more-actions-dropdown">Send to</button><div id="more-actions-dropdown" class="dropdown dropdown-container" hidden><div class="content"><ul class="more-actions-links"><li><a class="clipboard-panel-trigger dropdown-block-link "
|
||
href="#"
|
||
role="button"
|
||
data-ga-category="save_share"
|
||
data-ga-action="clipboard"
|
||
data-ga-label="send">
|
||
Clipboard
|
||
</a></li><li><a role="button" class="dropdown-block-link bibliography-trigger-target" href="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F29599784%2F%23open-bibliography-panel">My Bibliography</a></li><li><a role="button" class="dropdown-block-link collections-trigger-target" href="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F29599784%2F%23open-collections-panel">Collections</a></li><li><a role="button" class="citation-manager-panel-trigger dropdown-block-link citation-manager-trigger-target" href="#">Citation manager</a></li></ul></div></div></div>
|
||
</div>
|
||
|
||
|
||
|
||
<div class="display-options" data-format-key="format"
|
||
data-default-format-value="abstract"
|
||
data-current-format-value="abstract" role="region">
|
||
<button
|
||
class="trigger usa-button"
|
||
title="Change format"
|
||
data-ga-category="display_options"
|
||
data-ga-action="display_options_dialog">
|
||
<span class="button-label">Display options</span>
|
||
</button>
|
||
|
||
<div class="dropdown" hidden>
|
||
<div class="title">
|
||
Display options
|
||
</div>
|
||
|
||
<div class="content">
|
||
|
||
<div class="format-container">
|
||
<span class="option-label">
|
||
Format
|
||
</span>
|
||
<select name="format" data-initial-value="abstract" aria-label="Display format" id="article-display-format">
|
||
<option value="abstract">Abstract</option>
|
||
|
||
<option value="pubmed">PubMed</option>
|
||
|
||
<option value="pmid">PMID</option>
|
||
|
||
</select>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="mFV1aSEckD7kj1PRuWIMVz0eRRaiAYPnDsF6NI7yUeUOdsVH7flOpHwSpVSutznH">
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="article-panels-container" class="article-panels-container">
|
||
<div id="save-action-panel" class="save-action-panel action-panel" aria-hidden="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Save citation to file
|
||
</h2>
|
||
<form id="save-action-panel-form"
|
||
class="action-panel-content action-form"
|
||
action="/results-export-ids/"
|
||
data-by-search-action="/results-export-search-data/"
|
||
data-by-ids-action="/results-export-ids/"
|
||
method="post"
|
||
data-by-search-method="post"
|
||
data-by-ids-method="post">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="mFV1aSEckD7kj1PRuWIMVz0eRRaiAYPnDsF6NI7yUeUOdsVH7flOpHwSpVSutznH">
|
||
|
||
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="save-action-format" class="action-panel-label">
|
||
Format:
|
||
</label>
|
||
<select id="save-action-format" name="results-format" class="action-panel-selector">
|
||
<option value="summary-text">Summary (text)</option>
|
||
<option value="pubmed-text">PubMed</option>
|
||
<option value="pmid">PMID</option>
|
||
<option value="abstract">Abstract (text)</option>
|
||
<option value="csv">CSV</option>
|
||
</select>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Saving..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="save"
|
||
data-ga-label="save">
|
||
Create file
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Save citations to file' panel"
|
||
ref="linksrc=close_save_panel"
|
||
aria-controls="save-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="save"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div id="email-action-panel"
|
||
class="email-action-panel action-panel"
|
||
aria-hidden="true"
|
||
data-recaptcha-script-url="https://www.recaptcha.net/recaptcha/enterprise.js?render=explicit&onload=onloadCaptchaCallback"
|
||
data-recaptcha-enabled="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Email citation
|
||
</h2>
|
||
<form id="email-action-panel-form"
|
||
class="action-panel-content action-form"
|
||
action="/send-email/"
|
||
data-by-search-action="/results-export-email-by-search-data/"
|
||
data-by-ids-action="/send-email/"
|
||
data-by-search-method="post"
|
||
data-by-ids-method="post"
|
||
method="post"
|
||
>
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="mFV1aSEckD7kj1PRuWIMVz0eRRaiAYPnDsF6NI7yUeUOdsVH7flOpHwSpVSutznH">
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<span class="action-panel-label">
|
||
Subject:
|
||
</span>
|
||
<span class="email-subject" id="email-subject" aria-label="Email subject">1 selected item: 29599784 - PubMed</span>
|
||
<input type="hidden" name="email-subject" value="1 selected item: 29599784"/>
|
||
<input type="hidden" name="email-subject-hash" value="8f934157e2683b10f871e180040ec5a261ee3d17609e096890e8686153a5d3f8"/>
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="email-to" class="action-panel-label required-field-asterisk">
|
||
To:
|
||
</label>
|
||
<input type="email" aria-label="Recipient Email Address" placeholder="email@example.com" id="email-to" class="email-to" pattern="^[a-zA-Z0-9_.+-]+@[a-zA-Z0-9-]+\.[a-zA-Z0-9-.]+$" maxlength="100" required>
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="email-from" class="action-panel-label">
|
||
From:
|
||
</label>
|
||
<input type="email" aria-label="Sender Email Address" placeholder="email@example.com" id="email-from" class="email-from" pattern="^[a-zA-Z0-9_.+-]+@[a-zA-Z0-9-]+\.[a-zA-Z0-9-.]+$" maxlength="256">
|
||
</div>
|
||
|
||
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="email-citation-format" class="action-panel-label">
|
||
Format:
|
||
</label>
|
||
<select id="email-citation-format" name="citation-format" class="action-panel-selector email-citation-format">
|
||
<option selected="selected" value="summary">Summary</option>
|
||
<option value="summary-text">Summary (text)</option>
|
||
<option value="abstract">Abstract</option>
|
||
<option value="abstract-text">Abstract (text)</option>
|
||
|
||
</select>
|
||
</div>
|
||
<div class="include-supplemental-container">
|
||
<input type="checkbox" aria-label="Include MeSH and other data" name="include-supplemental" id="email-include-supplemental" class="email-include-supplemental">
|
||
<label for="email-include-supplemental" class="email-include-supplemental-label">MeSH and other data</label>
|
||
</div>
|
||
|
||
|
||
|
||
<div class="form-field recaptcha ">
|
||
|
||
|
||
|
||
<div class="g-recaptcha" id="id-recaptcha" data-sitekey="6LfsWHMdAAAAAClKbtOpjQ2pMjgsGxvv7NdZW9uI"></div>
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
<div id="captcha-error-message" class="usa-input-error-message captcha-validation-message" role="alert"></div>
|
||
|
||
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Sending..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="email"
|
||
data-ga-label="send">
|
||
Send email
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Email citations' panel"
|
||
ref="linksrc=close_email_panel"
|
||
aria-controls="email-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="email"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
<input type="hidden" name="email-search-details" value="" />
|
||
<input type="hidden" name="email-search-details-hash" value="0e42663a6c3bd85498fcb88798998fed7bfdc45d457db35281e41afe13cc0524" />
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="collections-action-panel"
|
||
class="collections-action-panel action-panel in-progress-dots-panel"
|
||
aria-hidden="true"
|
||
data-collections-open-panel-enabled="false"
|
||
data-collections-open-panel-url-hash="#open-collections-panel">
|
||
<div class="inner-wrap">
|
||
<h3 class="action-panel-heading">
|
||
Add to Collections
|
||
</h3>
|
||
|
||
|
||
<form id="collections-action-panel-form"
|
||
class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
|
||
data-existing-collections-url="/list-existing-collections/"
|
||
data-add-to-existing-collection-url="/add-to-existing-collection/"
|
||
data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/"
|
||
data-get-article-ids-by-search-url="/get-article-ids-by-search/"
|
||
data-myncbi-max-collection-name-length="100"
|
||
data-add-to-collection-max-amount="1000"
|
||
data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="mFV1aSEckD7kj1PRuWIMVz0eRRaiAYPnDsF6NI7yUeUOdsVH7flOpHwSpVSutznH">
|
||
|
||
|
||
|
||
<div class="choice-group" role="radiogroup">
|
||
<ul class="radio-group-items">
|
||
<li>
|
||
<input type="radio"
|
||
id="collections-action-panel-new"
|
||
class="collections-new"
|
||
name="collections"
|
||
value="new"
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="collections_radio_new">
|
||
<label for="collections-action-panel-new">Create a new collection</label>
|
||
</li>
|
||
<li>
|
||
<input type="radio"
|
||
id="collections-action-panel-existing"
|
||
class="collections-existing"
|
||
name="collections"
|
||
value="existing"
|
||
checked="true"
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="collections_radio_existing">
|
||
<label for="collections-action-panel-existing">Add to an existing collection</label>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
|
||
<div class="controls-wrapper">
|
||
<div class="action-panel-control-wrap new-collections-controls">
|
||
<label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk">
|
||
Name your collection:
|
||
</label>
|
||
<input
|
||
type="text"
|
||
name="add-to-new-collection"
|
||
id="collections-action-panel-add-to-new"
|
||
class="collections-action-add-to-new"
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"
|
||
maxlength="100"
|
||
data-ga-category="save_share"
|
||
data-ga-action="create_collection"
|
||
data-ga-label="non_favorties_collection">
|
||
<div class="collections-new-name-too-long usa-input-error-message selection-validation-message">
|
||
Name must be less than 100 characters
|
||
</div>
|
||
</div>
|
||
<div class="action-panel-control-wrap existing-collections-controls">
|
||
<label for="collections-action-panel-add-to-existing" class="action-panel-label">
|
||
Choose a collection:
|
||
</label>
|
||
<select id="collections-action-panel-add-to-existing"
|
||
class="action-panel-selector collections-action-add-to-existing"
|
||
data-ga-category="save_share"
|
||
data-ga-action="select_collection"
|
||
data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'">
|
||
</select>
|
||
<div class="collections-retry-load-on-error usa-input-error-message selection-validation-message">
|
||
Unable to load your collection due to an error<br>
|
||
<a href="#">Please try again</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Adding..."
|
||
data-pinger-ignore
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="add">
|
||
Add
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Add to Collections' panel"
|
||
ref="linksrc=close_collections_panel"
|
||
aria-controls="collections-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="bibliography-action-panel"
|
||
class="bibliography-action-panel action-panel in-progress-dots-panel"
|
||
aria-hidden="true"
|
||
data-bibliography-open-panel-enabled="false"
|
||
data-bibliography-open-panel-url-hash="#open-bibliography-panel">
|
||
<div class="inner-wrap">
|
||
<h3 class="action-panel-heading">
|
||
Add to My Bibliography
|
||
</h3>
|
||
<form id="bibliography-action-panel-form"
|
||
class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
|
||
data-add-to-bibliography-max-amount="100"
|
||
data-add-to-bibliography-batch-size="10"
|
||
data-bibliography-delegates-url="/list-bibliography-delegates/"
|
||
data-add-to-bibliography-url="/add-to-bibliography/"
|
||
data-get-article-ids-by-search-url="/get-article-ids-by-search/"
|
||
data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="mFV1aSEckD7kj1PRuWIMVz0eRRaiAYPnDsF6NI7yUeUOdsVH7flOpHwSpVSutznH">
|
||
|
||
|
||
|
||
<div class="action-panel-control-wrap bibliographies-controls">
|
||
<div class="choice-group">
|
||
<ul class="bibliographies-action-add radio-group-items">
|
||
<li>
|
||
<input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/>
|
||
<label for="my-bibliography">My Bibliography</label>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message">
|
||
Unable to load your delegates due to an error<br>
|
||
<a href="#">Please try again</a>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Adding..."
|
||
data-pinger-ignore>
|
||
Add
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Add to bibliography' panel"
|
||
ref="linksrc=close_bibliography_panel"
|
||
aria-controls="bibliography-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="mybib"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true"
|
||
data-saved-search-open-panel-enabled="false"
|
||
data-saved-search-open-panel-url-hash="#open-saved-search-panel">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Your saved search
|
||
</h2>
|
||
|
||
<form id="saved-search-action-panel-form"
|
||
class="saved-search-action-panel-form action-panel-content action-form"
|
||
data-create-saved-search-url="/create-saved-search/"
|
||
data-try-search-terms-url="/try-search-term/"
|
||
data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="mFV1aSEckD7kj1PRuWIMVz0eRRaiAYPnDsF6NI7yUeUOdsVH7flOpHwSpVSutznH">
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk">
|
||
Name of saved search:
|
||
</label>
|
||
<input maxlength="200"
|
||
type="text"
|
||
name="saved-search-name"
|
||
id="saved-search-name"
|
||
class="saved-search-name"
|
||
value=""
|
||
required
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/">
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-term" class="action-panel-label required-field-asterisk">
|
||
Search terms:
|
||
</label>
|
||
<textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea>
|
||
</div>
|
||
<div class="test-search-term-wrap">
|
||
<a href="#" class="try-search-term">Test search terms</a>
|
||
</div>
|
||
<div class="choice-group action-panel-extra-margin-top">
|
||
<span class="action-panel-label" id="fieldset-label">
|
||
Would you like email updates of new search results?
|
||
</span>
|
||
<fieldset id="saved-search-alert" aria-describedby="fieldset-label">
|
||
<legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend>
|
||
<ul class="radio-group-items">
|
||
<li>
|
||
<input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked>
|
||
<label for="saved-search-alert-yes" class="action-panel-label">Yes</label>
|
||
</li>
|
||
<li>
|
||
<input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no">
|
||
<label for="saved-search-alert-no" class="action-panel-label">No</label>
|
||
</li>
|
||
</ul>
|
||
</fieldset>
|
||
</div>
|
||
|
||
<div class="alert-schedule-wrap">
|
||
<div class="action-panel-control-wrap">
|
||
<label class="action-panel-label">
|
||
Email:
|
||
</label>
|
||
<span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span>
|
||
</div>
|
||
<div class="action-panel-control-wrap action-panel-extra-margin-top">
|
||
<label for="saved-search-frequency" class="action-panel-label">
|
||
Frequency:
|
||
</label>
|
||
<select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency">
|
||
<option value="monthly">Monthly</option>
|
||
<option value="weekly">Weekly</option>
|
||
<option value="daily">Daily</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap saved-search-monthly-additional">
|
||
<label for="saved-search-monthly-on-day" class="action-panel-label">
|
||
Which day?
|
||
</label>
|
||
<select id="saved-search-monthly-on-day" class="no-border-panel-selector">
|
||
<option value="Sunday">The first Sunday</option>
|
||
<option value="Monday">The first Monday</option>
|
||
<option value="Tuesday">The first Tuesday</option>
|
||
<option value="Wednesday">The first Wednesday</option>
|
||
<option value="Thursday">The first Thursday</option>
|
||
<option value="Friday">The first Friday</option>
|
||
<option value="Saturday">The first Saturday</option>
|
||
<option value="day">The first day</option>
|
||
<option value="weekday">The first weekday</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap saved-search-weekly-additional">
|
||
<label for="saved-search-weekly-on-day" class="action-panel-label">
|
||
Which day?
|
||
</label>
|
||
<select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day">
|
||
<option value="Sunday">Sunday</option>
|
||
<option value="Monday">Monday</option>
|
||
<option value="Tuesday">Tuesday</option>
|
||
<option value="Wednesday">Wednesday</option>
|
||
<option value="Thursday">Thursday</option>
|
||
<option value="Friday">Friday</option>
|
||
<option value="Saturday">Saturday</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-report" class="action-panel-label">
|
||
Report format:
|
||
</label>
|
||
<select id="saved-search-report" class="no-border-panel-selector saved-search-report">
|
||
<option value="DocSum">Summary</option>
|
||
<option value="DocSumText">Summary (text)</option>
|
||
<option value="Abstract">Abstract</option>
|
||
<option value="AbstractText">Abstract (text)</option>
|
||
<option value="MEDLINE">PubMed</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-amount" class="action-panel-label">
|
||
Send at most:
|
||
</label>
|
||
<select id="saved-search-amount" class="no-border-panel-selector saved-search-amount">
|
||
<option value="1">1 item</option>
|
||
<option value="5" selected>5 items</option>
|
||
<option value="10">10 items</option>
|
||
<option value="20">20 items</option>
|
||
<option value="50">50 items</option>
|
||
<option value="100">100 items</option>
|
||
<option value="200">200 items</option>
|
||
</select>
|
||
</div>
|
||
<div>
|
||
<input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result">
|
||
<label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox">
|
||
Send even when there aren't any new results
|
||
</label>
|
||
</div>
|
||
<div class="action-panel-control-wrap option-text-in-email-wrap">
|
||
<label for="saved-search-email-text" class="action-panel-label">
|
||
Optional text in email:
|
||
</label>
|
||
<textarea name="saved-search-email-text"
|
||
id="saved-search-email-text"
|
||
class="saved-search-email-text"></textarea>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Saving..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="save">
|
||
Save
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Your saved search' panel"
|
||
ref="linksrc=close_saved_search_panel"
|
||
aria-controls="saved-search-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Create a file for external citation management software
|
||
</h2>
|
||
<form id="citation-manager-action-panel-form"
|
||
class="action-panel-content action-form"
|
||
action="/results-export-ids/"
|
||
data-by-search-action="/results-export-search-data/"
|
||
data-by-ids-action="/results-export-ids/"
|
||
method="post"
|
||
data-by-search-method="post"
|
||
data-by-ids-method="post">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="mFV1aSEckD7kj1PRuWIMVz0eRRaiAYPnDsF6NI7yUeUOdsVH7flOpHwSpVSutznH">
|
||
|
||
|
||
|
||
<input name="results-format" type="hidden" value="pubmed"/>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Sending..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="citation_manager"
|
||
data-ga-label="save">
|
||
Create file
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Send citations to citation manager' panel"
|
||
ref="linksrc=close_citation_manager_panel"
|
||
aria-controls="citation-manager-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="citation_manager"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Your RSS Feed
|
||
</h2>
|
||
|
||
<form id="rss-action-panel-form"
|
||
class="rss-action-panel-form action-panel-content action-form"
|
||
data-create-rss-feed-url="/create-rss-feed-url/"
|
||
data-search-form-term-value="">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="mFV1aSEckD7kj1PRuWIMVz0eRRaiAYPnDsF6NI7yUeUOdsVH7flOpHwSpVSutznH">
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="rss-name" class="action-panel-label required-field-asterisk">
|
||
Name of RSS Feed:
|
||
</label>
|
||
<input maxlength="200"
|
||
placeholder="Name"
|
||
type="text"
|
||
name="rss-name"
|
||
id="rss-name"
|
||
class="rss-name"
|
||
value=''
|
||
required
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/">
|
||
</div>
|
||
|
||
<div class="rss-limit-wrap">
|
||
<div class="action-panel-control-wrap action-panel-extra-margin-top">
|
||
<label for="rss-limit" class="action-panel-label">
|
||
Number of items displayed:
|
||
</label>
|
||
<select id="rss-limit" class="no-border-panel-selector rss-limit">
|
||
<option value="5">5</option>
|
||
<option value="10">10</option>
|
||
<option value="15" selected="selected">15</option>
|
||
<option value="20">20</option>
|
||
<option value="50">50</option>
|
||
<option value="100">100</option>
|
||
</select>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Creating..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="save">
|
||
Create RSS
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Your RSS' panel"
|
||
ref="linksrc=close_rss_panel"
|
||
aria-controls="rss-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap rss-link-copy-wrap">
|
||
<label for="rss-link" class="usa-sr-only">RSS Link</label>
|
||
<input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link">
|
||
<button
|
||
type="button"
|
||
disabled
|
||
class="rss-link-copy-button disabled"
|
||
data-ga-category="save_share"
|
||
data-ga-action="rss"
|
||
data-ga-label="copy">
|
||
Copy
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="article-page" id="article-page" data-article-pmid="29599784">
|
||
<aside class="page-sidebar">
|
||
<div class="inner-wrap">
|
||
|
||
<div class="full-text-links">
|
||
<div class="full-view">
|
||
<h3 class="title">
|
||
Full text links
|
||
</h3>
|
||
<div class="full-text-links-list">
|
||
<a class="link-item
|
||
|
||
dialog-focus"
|
||
href="https://doi.org/10.3389/fimmu.2018.00543"
|
||
target="_blank"
|
||
rel="noopener"
|
||
|
||
ref="linksrc=fulltextorjournal_fulltext&is_pmc=False&PrId=6956&itool=Abstract-def&log$=linkouticon&uid=29599784&db=pubmed&nlmid=101560960"
|
||
title="See full text options at Frontiers Media SA"
|
||
|
||
data-ga-category="full_text"
|
||
data-ga-action="Frontiers Media SA"
|
||
data-ga-label="29599784"
|
||
><img src="https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--www.frontiersin.org-alerts-logo-PubMed.png" alt="Frontiers Media SA full text link"><span class="text">
|
||
|
||
Frontiers Media SA
|
||
|
||
</span></a><a class="link-item
|
||
pmc
|
||
"
|
||
href="https://pmc.ncbi.nlm.nih.gov/articles/pmid/29599784/"
|
||
target="_blank"
|
||
rel="noopener"
|
||
|
||
ref="linksrc=fulltextorjournal_fulltext&is_pmc=True&PrId=3494&itool=Abstract-def&log$=linkouticon&uid=29599784&db=pubmed&nlmid=101560960"
|
||
title="Free full text at PubMed Central"
|
||
|
||
data-ga-category="full_text"
|
||
data-ga-action="PMC"
|
||
data-ga-label="29599784"
|
||
><span class="text">
|
||
|
||
Free PMC article
|
||
|
||
</span></a>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="short-view">
|
||
<a href="#" class="full-text-links-button full-text-links-dialog-trigger">
|
||
Full text links
|
||
</a>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div class="actions-buttons sidebar"><h3 class="title">Actions</h3><div class="inner-wrap"><button class="citation-button citation-dialog-trigger"
|
||
aria-label="Open dialog with citation text in different styles"
|
||
data-ga-category="save_share"
|
||
data-ga-action="cite"
|
||
data-ga-label="open"
|
||
data-all-citations-url="/29599784/citations/"
|
||
data-citation-style="nlm"
|
||
data-pubmed-format-link="/29599784/export/"><span class="button-label">Cite</span></button><link type="text/css" href="ncbi-overlay-block/src/overlay-block.css"><div class="collections-button-container" data-article-id="29599784" data-article-db="pubmed"><button class="collections-button collections-dialog-trigger"
|
||
aria-label="Save article in MyNCBI collections."
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="collections_button"
|
||
data-collections-open-dialog-enabled="false"
|
||
data-collections-open-dialog-url="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F29599784%2F%23open-collections-dialog"
|
||
data-in-collections="false"><span class="button-label">Collections</span></button><div class="overlay" role="dialog"><div id="collections-action-dialog"
|
||
class="dialog collections-dialog"
|
||
aria-hidden="true"><div class="title">Add to Collections</div><div class="collections-action-panel action-panel"><form id="collections-action-dialog-form"
|
||
class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
|
||
data-existing-collections-url="/list-existing-collections/"
|
||
data-add-to-existing-collection-url="/add-to-existing-collection/"
|
||
data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/"
|
||
data-myncbi-max-collection-name-length="100"
|
||
data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"><input type="hidden" name="csrfmiddlewaretoken" value="mFV1aSEckD7kj1PRuWIMVz0eRRaiAYPnDsF6NI7yUeUOdsVH7flOpHwSpVSutznH"><div class="choice-group" role="radiogroup"><ul class="radio-group-items"><li><input type="radio"
|
||
id="collections-action-dialog-new"
|
||
class="collections-new"
|
||
name="collections"
|
||
value="new"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="collections_radio_new"><label for="collections-action-dialog-new">Create a new collection</label></li><li><input type="radio"
|
||
id="collections-action-dialog-existing"
|
||
class="collections-existing"
|
||
name="collections"
|
||
value="existing"
|
||
checked="true"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li></ul></div><div class="controls-wrapper"><div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk">
|
||
Name your collection:
|
||
</label><input
|
||
type="text"
|
||
name="add-to-new-collection"
|
||
id="collections-action-dialog-add-to-new"
|
||
class="collections-action-add-to-new"
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"
|
||
maxlength="100"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="create_collection"
|
||
data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message">
|
||
Name must be less than 100 characters
|
||
</div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label">
|
||
Choose a collection:
|
||
</label><select id="collections-action-dialog-add-to-existing"
|
||
class="action-panel-selector collections-action-add-to-existing"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="select_collection"
|
||
data-ga-label="($('.collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"></select><div class="collections-retry-load-on-error usa-input-error-message selection-validation-message">
|
||
Unable to load your collection due to an error<br><a href="#">Please try again</a></div></div></div><div class="action-panel-actions"><button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Adding..."
|
||
data-pinger-ignore
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
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Disease Evolution and Response to Rapamycin in Activated Phosphoinositide 3-Kinase δ Syndrome: The European Society for Immunodeficiencies-Activated Phosphoinositide 3-Kinase δ Syndrome Registry
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data-ga-label="Federica Barzaghi">Federica Barzaghi</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy." href="#full-view-affiliation-5" ref="linksrc=author_aff">
|
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5
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Helen Baxendale">Helen Baxendale</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Cambridge Centre for Lung Defense, Papworth Hospital, Cambridge, United Kingdom." href="#full-view-affiliation-9" ref="linksrc=author_aff">
|
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9
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Buckland+M&cauthor_id=29599784"
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data-ga-label="Matthew Buckland">Matthew Buckland</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Institute of Immunity and Transplantation, Royal Free Hospital, London, United Kingdom." href="#full-view-affiliation-10" ref="linksrc=author_aff">
|
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10
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Burns+SO&cauthor_id=29599784"
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data-ga-label="Siobhan O Burns">Siobhan O Burns</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Institute of Immunity and Transplantation, Royal Free Hospital, London, United Kingdom." href="#full-view-affiliation-10" ref="linksrc=author_aff">
|
||
10
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Cancrini+C&cauthor_id=29599784"
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data-ga-label="Caterina Cancrini">Caterina Cancrini</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="University Department of Pediatrics, Bambino Gesù Children's Hospital IRCCS, Rome, Italy." href="#full-view-affiliation-11" ref="linksrc=author_aff">
|
||
11
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy." href="#full-view-affiliation-12" ref="linksrc=author_aff">
|
||
12
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Cant+A&cauthor_id=29599784"
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data-ga-label="Andrew Cant">Andrew Cant</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Paediatric Immunology, Newcastle upon Tyne Hospital NHS Foundation Trust, Newcastle upon Tyne, United Kingdom." href="#full-view-affiliation-13" ref="linksrc=author_aff">
|
||
13
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Cath%C3%A9bras+P&cauthor_id=29599784"
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data-ga-label="Pascal Cathébras">Pascal Cathébras</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Internal Medicine, University Hospital of Saint-Etienne, Saint-Etienne, France." href="#full-view-affiliation-14" ref="linksrc=author_aff">
|
||
14
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Cavazzana+M&cauthor_id=29599784"
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data-ga-label="Marina Cavazzana">Marina Cavazzana</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Biotherapy Department, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Children's Hospital, Paris, France." href="#full-view-affiliation-15" ref="linksrc=author_aff">
|
||
15
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Laboratory of Human Lymphohematopoiesis, INSERM UMR 1163, Imagine Institute, Paris, France." href="#full-view-affiliation-16" ref="linksrc=author_aff">
|
||
16
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Paris Descartes-Sorbonne Paris Cité University, Paris, France." href="#full-view-affiliation-17" ref="linksrc=author_aff">
|
||
17
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Chandra+A&cauthor_id=29599784"
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data-ga-label="Anita Chandra">Anita Chandra</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Clinical Immunology, Addenbrookes Hospital, Cambridge, United Kingdom." href="#full-view-affiliation-18" ref="linksrc=author_aff">
|
||
18
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Medicine, University of Cambridge, Cambridge, United Kingdom." href="#full-view-affiliation-19" ref="linksrc=author_aff">
|
||
19
|
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Conti+F&cauthor_id=29599784"
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data-ga-label="Francesca Conti">Francesca Conti</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="University Department of Pediatrics, Bambino Gesù Children's Hospital IRCCS, Rome, Italy." href="#full-view-affiliation-11" ref="linksrc=author_aff">
|
||
11
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy." href="#full-view-affiliation-12" ref="linksrc=author_aff">
|
||
12
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Coulter+T&cauthor_id=29599784"
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data-ga-label="Tanya Coulter">Tanya Coulter</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Regional Immunology Service, The Royal Hospitals & Queen's University, Belfast, United Kingdom." href="#full-view-affiliation-20" ref="linksrc=author_aff">
|
||
20
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Devlin+LA&cauthor_id=29599784"
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data-ga-label="Lisa A Devlin">Lisa A Devlin</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Regional Immunology Service, The Royal Hospitals & Queen's University, Belfast, United Kingdom." href="#full-view-affiliation-20" ref="linksrc=author_aff">
|
||
20
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Edgar+JDM&cauthor_id=29599784"
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data-ga-label="J David M Edgar">J David M Edgar</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Regional Immunology Service, The Royal Hospitals & Queen's University, Belfast, United Kingdom." href="#full-view-affiliation-20" ref="linksrc=author_aff">
|
||
20
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Faust+S&cauthor_id=29599784"
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data-ga-label="Saul Faust">Saul Faust</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="NIHR Clinical Research Facility, University Hospital Southampton NHSFT, Southampton, United Kingdom." href="#full-view-affiliation-21" ref="linksrc=author_aff">
|
||
21
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Fischer+A&cauthor_id=29599784"
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data-ga-label="Alain Fischer">Alain Fischer</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Paris Descartes-Sorbonne Paris Cité University, Paris, France." href="#full-view-affiliation-17" ref="linksrc=author_aff">
|
||
17
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Pediatric Immunology, Hematology and Rheumatology, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Children's Hospital, Paris, France." href="#full-view-affiliation-22" ref="linksrc=author_aff">
|
||
22
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="INSERM UMR 1163, Imagine Institute, Paris, France." href="#full-view-affiliation-23" ref="linksrc=author_aff">
|
||
23
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Garcia-Prat+M&cauthor_id=29599784"
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data-ga-label="Marina Garcia-Prat">Marina Garcia-Prat</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain." href="#full-view-affiliation-24" ref="linksrc=author_aff">
|
||
24
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Hammarstr%C3%B6m+L&cauthor_id=29599784"
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data-ga-label="Lennart Hammarström">Lennart Hammarström</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden." href="#full-view-affiliation-3" ref="linksrc=author_aff">
|
||
3
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Heeg+M&cauthor_id=29599784"
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data-ga-label="Maximilian Heeg">Maximilian Heeg</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Freiburg, Germany." href="#full-view-affiliation-1" ref="linksrc=author_aff">
|
||
1
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Pediatrics and Adolescent Medicine, Medical Center - University of Freiburg, Freiburg, Germany." href="#full-view-affiliation-2" ref="linksrc=author_aff">
|
||
2
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Jolles+S&cauthor_id=29599784"
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data-ga-label="Stephen Jolles">Stephen Jolles</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Immunodeficiency Centre for Wales, University Hospital of Wales, Cardiff, United Kingdom." href="#full-view-affiliation-25" ref="linksrc=author_aff">
|
||
25
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Karakoc-Aydiner+E&cauthor_id=29599784"
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data-ga-label="Elif Karakoc-Aydiner">Elif Karakoc-Aydiner</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Division of Pediatric Allergy/Immunology, Marmara University, Istanbul, Turkey." href="#full-view-affiliation-8" ref="linksrc=author_aff">
|
||
8
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Kindle+G&cauthor_id=29599784"
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data-ga-label="Gerhard Kindle">Gerhard Kindle</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Freiburg, Germany." href="#full-view-affiliation-1" ref="linksrc=author_aff">
|
||
1
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Kiykim+A&cauthor_id=29599784"
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data-ga-label="Ayca Kiykim">Ayca Kiykim</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Division of Pediatric Allergy/Immunology, Marmara University, Istanbul, Turkey." href="#full-view-affiliation-8" ref="linksrc=author_aff">
|
||
8
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Kumararatne+D&cauthor_id=29599784"
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data-ga-label="Dinakantha Kumararatne">Dinakantha Kumararatne</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Paris Descartes-Sorbonne Paris Cité University, Paris, France." href="#full-view-affiliation-17" ref="linksrc=author_aff">
|
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17
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Grimbacher+B&cauthor_id=29599784"
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data-ga-label="Bodo Grimbacher">Bodo Grimbacher</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Freiburg, Germany." href="#full-view-affiliation-1" ref="linksrc=author_aff">
|
||
1
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Longhurst+H&cauthor_id=29599784"
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data-ga-label="Hilary Longhurst">Hilary Longhurst</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Institute of Immunity and Transplantation, Royal Free Hospital, London, United Kingdom." href="#full-view-affiliation-10" ref="linksrc=author_aff">
|
||
10
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Mahlaoui+N&cauthor_id=29599784"
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data-ga-label="Nizar Mahlaoui">Nizar Mahlaoui</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Pediatric Immunology, Hematology and Rheumatology, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Children's Hospital, Paris, France." href="#full-view-affiliation-22" ref="linksrc=author_aff">
|
||
22
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="French National Reference Center for Primary Immune Deficiencies (CEREDIH), Necker Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France." href="#full-view-affiliation-26" ref="linksrc=author_aff">
|
||
26
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Milota+T&cauthor_id=29599784"
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data-ga-label="Tomas Milota">Tomas Milota</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Immunology, 2nd Faculty of Medicine Charles University and Motol University Hospital, Prague, Czechia." href="#full-view-affiliation-27" ref="linksrc=author_aff">
|
||
27
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Moreira+F&cauthor_id=29599784"
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data-ga-label="Fernando Moreira">Fernando Moreira</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Institute of Immunity and Transplantation, Royal Free Hospital, London, United Kingdom." href="#full-view-affiliation-10" ref="linksrc=author_aff">
|
||
10
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Moshous+D&cauthor_id=29599784"
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data-ga-label="Despina Moshous">Despina Moshous</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Paris Descartes-Sorbonne Paris Cité University, Paris, France." href="#full-view-affiliation-17" ref="linksrc=author_aff">
|
||
17
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Pediatric Immunology, Hematology and Rheumatology, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Children's Hospital, Paris, France." href="#full-view-affiliation-22" ref="linksrc=author_aff">
|
||
22
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="INSERM UMR 1163, Imagine Institute, Paris, France." href="#full-view-affiliation-23" ref="linksrc=author_aff">
|
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23
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Mukhina+A&cauthor_id=29599784"
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data-ga-label="Anna Mukhina">Anna Mukhina</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Immunology, Research and Clinical Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russia." href="#full-view-affiliation-28" ref="linksrc=author_aff">
|
||
28
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Neth+O&cauthor_id=29599784"
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data-ga-label="Olaf Neth">Olaf Neth</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Sección de Infectologıa, Rheumatología and Inmunodeficiencias, Unidad de Pediatria, Hospital Virgen del Rocıo, Instituto de Biomedicina de Sevilla (IBiS), Sevilla, Spain." href="#full-view-affiliation-29" ref="linksrc=author_aff">
|
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29
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||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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17
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</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Pediatric Immunology, Hematology and Rheumatology, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Children's Hospital, Paris, France." href="#full-view-affiliation-22" ref="linksrc=author_aff">
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22
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</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Laboratory of Immunogenetics of Pediatric Autoimmunity, INSERM UMR 1163, Imagine Institute, Paris, France." href="#full-view-affiliation-30" ref="linksrc=author_aff">
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30
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1
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29
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8
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31
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32
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33
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31
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21
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31
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1
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32
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11
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12
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1
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27
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6
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28
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12
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24
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15
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5
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1
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34
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1
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21
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35
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16
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17
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36
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1
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2
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|
||
|
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<li data-affiliation-id="full-view-affiliation-4"
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><sup class="key">4</sup> Research Center for Immunodeficiencies, Pediatric Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-5"
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id="full-view-affiliation-5"
|
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><sup class="key">5</sup> San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.</li>
|
||
|
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<li data-affiliation-id="full-view-affiliation-6"
|
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id="full-view-affiliation-6"
|
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><sup class="key">6</sup> Research Department, Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus.</li>
|
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<li data-affiliation-id="full-view-affiliation-7"
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><sup class="key">7</sup> Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.</li>
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<li data-affiliation-id="full-view-affiliation-8"
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<li data-affiliation-id="full-view-affiliation-9"
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><sup class="key">9</sup> Cambridge Centre for Lung Defense, Papworth Hospital, Cambridge, United Kingdom.</li>
|
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><sup class="key">10</sup> Institute of Immunity and Transplantation, Royal Free Hospital, London, United Kingdom.</li>
|
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|
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><sup class="key">11</sup> University Department of Pediatrics, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.</li>
|
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<li data-affiliation-id="full-view-affiliation-12"
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><sup class="key">12</sup> Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.</li>
|
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|
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<li data-affiliation-id="full-view-affiliation-15"
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|
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><sup class="key">21</sup> NIHR Clinical Research Facility, University Hospital Southampton NHSFT, Southampton, United Kingdom.</li>
|
||
|
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<li data-affiliation-id="full-view-affiliation-22"
|
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id="full-view-affiliation-22"
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><sup class="key">22</sup> Department of Pediatric Immunology, Hematology and Rheumatology, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Children's Hospital, Paris, France.</li>
|
||
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<li data-affiliation-id="full-view-affiliation-23"
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><sup class="key">23</sup> INSERM UMR 1163, Imagine Institute, Paris, France.</li>
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<li data-affiliation-id="full-view-affiliation-24"
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id="full-view-affiliation-24"
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><sup class="key">24</sup> Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.</li>
|
||
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<li data-affiliation-id="full-view-affiliation-25"
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id="full-view-affiliation-25"
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><sup class="key">25</sup> Immunodeficiency Centre for Wales, University Hospital of Wales, Cardiff, United Kingdom.</li>
|
||
|
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<li data-affiliation-id="full-view-affiliation-26"
|
||
id="full-view-affiliation-26"
|
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><sup class="key">26</sup> French National Reference Center for Primary Immune Deficiencies (CEREDIH), Necker Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-27"
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id="full-view-affiliation-27"
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><sup class="key">27</sup> Department of Immunology, 2nd Faculty of Medicine Charles University and Motol University Hospital, Prague, Czechia.</li>
|
||
|
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<li data-affiliation-id="full-view-affiliation-28"
|
||
id="full-view-affiliation-28"
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><sup class="key">28</sup> Department of Immunology, Research and Clinical Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russia.</li>
|
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|
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<li data-affiliation-id="full-view-affiliation-29"
|
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id="full-view-affiliation-29"
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><sup class="key">29</sup> Sección de Infectologıa, Rheumatología and Inmunodeficiencias, Unidad de Pediatria, Hospital Virgen del Rocıo, Instituto de Biomedicina de Sevilla (IBiS), Sevilla, Spain.</li>
|
||
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<li data-affiliation-id="full-view-affiliation-30"
|
||
id="full-view-affiliation-30"
|
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><sup class="key">30</sup> Laboratory of Immunogenetics of Pediatric Autoimmunity, INSERM UMR 1163, Imagine Institute, Paris, France.</li>
|
||
|
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<li data-affiliation-id="full-view-affiliation-31"
|
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id="full-view-affiliation-31"
|
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><sup class="key">31</sup> Division of Immunology, University Children's Hospital Zurich and Children's Research Centre, University Zurich, Zurich, Switzerland.</li>
|
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<li data-affiliation-id="full-view-affiliation-32"
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id="full-view-affiliation-32"
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><sup class="key">32</sup> Study Center for Primary Immunodeficiencies, Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Medical School, Paris, France.</li>
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<li data-affiliation-id="full-view-affiliation-33"
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><sup class="key">33</sup> Laboratory of Lymphocyte Activation and Susceptibility to EBV Infection, INSERM UMR 1163, Imagine Institute, Paris, France.</li>
|
||
|
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<li data-affiliation-id="full-view-affiliation-34"
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><sup class="key">34</sup> Wilhelmina Children's Hospital, Utrecht, Netherlands.</li>
|
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|
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<li data-affiliation-id="full-view-affiliation-35"
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><sup class="key">35</sup> Department of Clinical Immunology and Allergy, St James's University Hospital, Leeds, United Kingdom.</li>
|
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|
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<li data-affiliation-id="full-view-affiliation-36"
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id="full-view-affiliation-36"
|
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><sup class="key">36</sup> Department of Infection, Immunity and Cardiovascular Science, University of Sheffield, Sheffield, United Kingdom.</li>
|
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|
||
</ul>
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</div>
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<h1 class="heading-title">
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Disease Evolution and Response to Rapamycin in Activated Phosphoinositide 3-Kinase δ Syndrome: The European Society for Immunodeficiencies-Activated Phosphoinositide 3-Kinase δ Syndrome Registry
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</h1>
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<div class="short-citation">
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<span class="authors-list-item "><span class="full-name">Maria Elena Maccari</span><span class="citation-separator"> et al.</span></span>
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6
|
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Catherine Bangs">Catherine Bangs</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom." href="#short-view-affiliation-7" ref="linksrc=author_aff">
|
||
7
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Baris+S&cauthor_id=29599784"
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data-ga-label="Safa Baris">Safa Baris</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Division of Pediatric Allergy/Immunology, Marmara University, Istanbul, Turkey." href="#short-view-affiliation-8" ref="linksrc=author_aff">
|
||
8
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Barzaghi+F&cauthor_id=29599784"
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data-ga-label="Federica Barzaghi">Federica Barzaghi</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy." href="#short-view-affiliation-5" ref="linksrc=author_aff">
|
||
5
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Baxendale+H&cauthor_id=29599784"
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data-ga-label="Helen Baxendale">Helen Baxendale</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Cambridge Centre for Lung Defense, Papworth Hospital, Cambridge, United Kingdom." href="#short-view-affiliation-9" ref="linksrc=author_aff">
|
||
9
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Buckland+M&cauthor_id=29599784"
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data-ga-label="Matthew Buckland">Matthew Buckland</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Institute of Immunity and Transplantation, Royal Free Hospital, London, United Kingdom." href="#short-view-affiliation-10" ref="linksrc=author_aff">
|
||
10
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Burns+SO&cauthor_id=29599784"
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data-ga-label="Siobhan O Burns">Siobhan O Burns</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Institute of Immunity and Transplantation, Royal Free Hospital, London, United Kingdom." href="#short-view-affiliation-10" ref="linksrc=author_aff">
|
||
10
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Cancrini+C&cauthor_id=29599784"
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data-ga-label="Caterina Cancrini">Caterina Cancrini</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="University Department of Pediatrics, Bambino Gesù Children's Hospital IRCCS, Rome, Italy." href="#short-view-affiliation-11" ref="linksrc=author_aff">
|
||
11
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy." href="#short-view-affiliation-12" ref="linksrc=author_aff">
|
||
12
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Cant+A&cauthor_id=29599784"
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data-ga-label="Andrew Cant">Andrew Cant</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Paediatric Immunology, Newcastle upon Tyne Hospital NHS Foundation Trust, Newcastle upon Tyne, United Kingdom." href="#short-view-affiliation-13" ref="linksrc=author_aff">
|
||
13
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Cath%C3%A9bras+P&cauthor_id=29599784"
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data-ga-label="Pascal Cathébras">Pascal Cathébras</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Internal Medicine, University Hospital of Saint-Etienne, Saint-Etienne, France." href="#short-view-affiliation-14" ref="linksrc=author_aff">
|
||
14
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Cavazzana+M&cauthor_id=29599784"
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data-ga-label="Marina Cavazzana">Marina Cavazzana</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Biotherapy Department, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Children's Hospital, Paris, France." href="#short-view-affiliation-15" ref="linksrc=author_aff">
|
||
15
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Laboratory of Human Lymphohematopoiesis, INSERM UMR 1163, Imagine Institute, Paris, France." href="#short-view-affiliation-16" ref="linksrc=author_aff">
|
||
16
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Paris Descartes-Sorbonne Paris Cité University, Paris, France." href="#short-view-affiliation-17" ref="linksrc=author_aff">
|
||
17
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Chandra+A&cauthor_id=29599784"
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data-ga-label="Anita Chandra">Anita Chandra</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Clinical Immunology, Addenbrookes Hospital, Cambridge, United Kingdom." href="#short-view-affiliation-18" ref="linksrc=author_aff">
|
||
18
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Medicine, University of Cambridge, Cambridge, United Kingdom." href="#short-view-affiliation-19" ref="linksrc=author_aff">
|
||
19
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Conti+F&cauthor_id=29599784"
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data-ga-label="Francesca Conti">Francesca Conti</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="University Department of Pediatrics, Bambino Gesù Children's Hospital IRCCS, Rome, Italy." href="#short-view-affiliation-11" ref="linksrc=author_aff">
|
||
11
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy." href="#short-view-affiliation-12" ref="linksrc=author_aff">
|
||
12
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Coulter+T&cauthor_id=29599784"
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data-ga-label="Tanya Coulter">Tanya Coulter</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Regional Immunology Service, The Royal Hospitals & Queen's University, Belfast, United Kingdom." href="#short-view-affiliation-20" ref="linksrc=author_aff">
|
||
20
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Devlin+LA&cauthor_id=29599784"
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data-ga-label="Lisa A Devlin">Lisa A Devlin</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Regional Immunology Service, The Royal Hospitals & Queen's University, Belfast, United Kingdom." href="#short-view-affiliation-20" ref="linksrc=author_aff">
|
||
20
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Edgar+JDM&cauthor_id=29599784"
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data-ga-label="J David M Edgar">J David M Edgar</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Regional Immunology Service, The Royal Hospitals & Queen's University, Belfast, United Kingdom." href="#short-view-affiliation-20" ref="linksrc=author_aff">
|
||
20
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Faust+S&cauthor_id=29599784"
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data-ga-label="Saul Faust">Saul Faust</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="NIHR Clinical Research Facility, University Hospital Southampton NHSFT, Southampton, United Kingdom." href="#short-view-affiliation-21" ref="linksrc=author_aff">
|
||
21
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Fischer+A&cauthor_id=29599784"
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data-ga-label="Alain Fischer">Alain Fischer</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Paris Descartes-Sorbonne Paris Cité University, Paris, France." href="#short-view-affiliation-17" ref="linksrc=author_aff">
|
||
17
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Pediatric Immunology, Hematology and Rheumatology, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Children's Hospital, Paris, France." href="#short-view-affiliation-22" ref="linksrc=author_aff">
|
||
22
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="INSERM UMR 1163, Imagine Institute, Paris, France." href="#short-view-affiliation-23" ref="linksrc=author_aff">
|
||
23
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Garcia-Prat+M&cauthor_id=29599784"
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ref="linksrc=author_name_link"
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data-ga-label="Marina Garcia-Prat">Marina Garcia-Prat</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain." href="#short-view-affiliation-24" ref="linksrc=author_aff">
|
||
24
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Hammarstr%C3%B6m+L&cauthor_id=29599784"
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data-ga-label="Lennart Hammarström">Lennart Hammarström</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden." href="#short-view-affiliation-3" ref="linksrc=author_aff">
|
||
3
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Heeg+M&cauthor_id=29599784"
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ref="linksrc=author_name_link"
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data-ga-label="Maximilian Heeg">Maximilian Heeg</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Freiburg, Germany." href="#short-view-affiliation-1" ref="linksrc=author_aff">
|
||
1
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Pediatrics and Adolescent Medicine, Medical Center - University of Freiburg, Freiburg, Germany." href="#short-view-affiliation-2" ref="linksrc=author_aff">
|
||
2
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Jolles+S&cauthor_id=29599784"
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data-ga-label="Stephen Jolles">Stephen Jolles</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Immunodeficiency Centre for Wales, University Hospital of Wales, Cardiff, United Kingdom." href="#short-view-affiliation-25" ref="linksrc=author_aff">
|
||
25
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Karakoc-Aydiner+E&cauthor_id=29599784"
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data-ga-label="Elif Karakoc-Aydiner">Elif Karakoc-Aydiner</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Division of Pediatric Allergy/Immunology, Marmara University, Istanbul, Turkey." href="#short-view-affiliation-8" ref="linksrc=author_aff">
|
||
8
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Kindle+G&cauthor_id=29599784"
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ref="linksrc=author_name_link"
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data-ga-label="Gerhard Kindle">Gerhard Kindle</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Freiburg, Germany." href="#short-view-affiliation-1" ref="linksrc=author_aff">
|
||
1
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Kiykim+A&cauthor_id=29599784"
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data-ga-label="Ayca Kiykim">Ayca Kiykim</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Division of Pediatric Allergy/Immunology, Marmara University, Istanbul, Turkey." href="#short-view-affiliation-8" ref="linksrc=author_aff">
|
||
8
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Kumararatne+D&cauthor_id=29599784"
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data-ga-label="Dinakantha Kumararatne">Dinakantha Kumararatne</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Paris Descartes-Sorbonne Paris Cité University, Paris, France." href="#short-view-affiliation-17" ref="linksrc=author_aff">
|
||
17
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Grimbacher+B&cauthor_id=29599784"
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data-ga-label="Bodo Grimbacher">Bodo Grimbacher</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Freiburg, Germany." href="#short-view-affiliation-1" ref="linksrc=author_aff">
|
||
1
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Longhurst+H&cauthor_id=29599784"
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data-ga-label="Hilary Longhurst">Hilary Longhurst</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Institute of Immunity and Transplantation, Royal Free Hospital, London, United Kingdom." href="#short-view-affiliation-10" ref="linksrc=author_aff">
|
||
10
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Mahlaoui+N&cauthor_id=29599784"
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data-ga-label="Nizar Mahlaoui">Nizar Mahlaoui</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Pediatric Immunology, Hematology and Rheumatology, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Children's Hospital, Paris, France." href="#short-view-affiliation-22" ref="linksrc=author_aff">
|
||
22
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="French National Reference Center for Primary Immune Deficiencies (CEREDIH), Necker Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France." href="#short-view-affiliation-26" ref="linksrc=author_aff">
|
||
26
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Milota+T&cauthor_id=29599784"
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data-ga-label="Tomas Milota">Tomas Milota</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Immunology, 2nd Faculty of Medicine Charles University and Motol University Hospital, Prague, Czechia." href="#short-view-affiliation-27" ref="linksrc=author_aff">
|
||
27
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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||
href="/?term=Moreira+F&cauthor_id=29599784"
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data-ga-label="Fernando Moreira">Fernando Moreira</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Institute of Immunity and Transplantation, Royal Free Hospital, London, United Kingdom." href="#short-view-affiliation-10" ref="linksrc=author_aff">
|
||
10
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Moshous+D&cauthor_id=29599784"
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data-ga-label="Despina Moshous">Despina Moshous</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Paris Descartes-Sorbonne Paris Cité University, Paris, France." href="#short-view-affiliation-17" ref="linksrc=author_aff">
|
||
17
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Pediatric Immunology, Hematology and Rheumatology, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Children's Hospital, Paris, France." href="#short-view-affiliation-22" ref="linksrc=author_aff">
|
||
22
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="INSERM UMR 1163, Imagine Institute, Paris, France." href="#short-view-affiliation-23" ref="linksrc=author_aff">
|
||
23
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Mukhina+A&cauthor_id=29599784"
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data-ga-label="Anna Mukhina">Anna Mukhina</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Immunology, Research and Clinical Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russia." href="#short-view-affiliation-28" ref="linksrc=author_aff">
|
||
28
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Neth+O&cauthor_id=29599784"
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data-ga-label="Olaf Neth">Olaf Neth</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Sección de Infectologıa, Rheumatología and Inmunodeficiencias, Unidad de Pediatria, Hospital Virgen del Rocıo, Instituto de Biomedicina de Sevilla (IBiS), Sevilla, Spain." href="#short-view-affiliation-29" ref="linksrc=author_aff">
|
||
29
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Neven+B&cauthor_id=29599784"
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ref="linksrc=author_name_link"
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data-ga-label="Benedicte Neven">Benedicte Neven</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Paris Descartes-Sorbonne Paris Cité University, Paris, France." href="#short-view-affiliation-17" ref="linksrc=author_aff">
|
||
17
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Pediatric Immunology, Hematology and Rheumatology, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Children's Hospital, Paris, France." href="#short-view-affiliation-22" ref="linksrc=author_aff">
|
||
22
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Laboratory of Immunogenetics of Pediatric Autoimmunity, INSERM UMR 1163, Imagine Institute, Paris, France." href="#short-view-affiliation-30" ref="linksrc=author_aff">
|
||
30
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Nieters+A&cauthor_id=29599784"
|
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ref="linksrc=author_name_link"
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data-ga-label="Alexandra Nieters">Alexandra Nieters</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Freiburg, Germany." href="#short-view-affiliation-1" ref="linksrc=author_aff">
|
||
1
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Olbrich+P&cauthor_id=29599784"
|
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ref="linksrc=author_name_link"
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data-ga-label="Peter Olbrich">Peter Olbrich</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Sección de Infectologıa, Rheumatología and Inmunodeficiencias, Unidad de Pediatria, Hospital Virgen del Rocıo, Instituto de Biomedicina de Sevilla (IBiS), Sevilla, Spain." href="#short-view-affiliation-29" ref="linksrc=author_aff">
|
||
29
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Ozen+A&cauthor_id=29599784"
|
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ref="linksrc=author_name_link"
|
||
data-ga-category="search"
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data-ga-label="Ahmet Ozen">Ahmet Ozen</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Division of Pediatric Allergy/Immunology, Marmara University, Istanbul, Turkey." href="#short-view-affiliation-8" ref="linksrc=author_aff">
|
||
8
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Pachlopnik+Schmid+J&cauthor_id=29599784"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
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data-ga-action="author_link"
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data-ga-label="Jana Pachlopnik Schmid">Jana Pachlopnik Schmid</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Division of Immunology, University Children's Hospital Zurich and Children's Research Centre, University Zurich, Zurich, Switzerland." href="#short-view-affiliation-31" ref="linksrc=author_aff">
|
||
31
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Picard+C&cauthor_id=29599784"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
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data-ga-action="author_link"
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data-ga-label="Capucine Picard">Capucine Picard</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Study Center for Primary Immunodeficiencies, Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Medical School, Paris, France." href="#short-view-affiliation-32" ref="linksrc=author_aff">
|
||
32
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Laboratory of Lymphocyte Activation and Susceptibility to EBV Infection, INSERM UMR 1163, Imagine Institute, Paris, France." href="#short-view-affiliation-33" ref="linksrc=author_aff">
|
||
33
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Prader+S&cauthor_id=29599784"
|
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ref="linksrc=author_name_link"
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data-ga-category="search"
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data-ga-action="author_link"
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data-ga-label="Seraina Prader">Seraina Prader</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Division of Immunology, University Children's Hospital Zurich and Children's Research Centre, University Zurich, Zurich, Switzerland." href="#short-view-affiliation-31" ref="linksrc=author_aff">
|
||
31
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Rae+W&cauthor_id=29599784"
|
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ref="linksrc=author_name_link"
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data-ga-category="search"
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data-ga-label="William Rae">William Rae</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="NIHR Clinical Research Facility, University Hospital Southampton NHSFT, Southampton, United Kingdom." href="#short-view-affiliation-21" ref="linksrc=author_aff">
|
||
21
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Reichenbach+J&cauthor_id=29599784"
|
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ref="linksrc=author_name_link"
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data-ga-category="search"
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data-ga-action="author_link"
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data-ga-label="Janine Reichenbach">Janine Reichenbach</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Division of Immunology, University Children's Hospital Zurich and Children's Research Centre, University Zurich, Zurich, Switzerland." href="#short-view-affiliation-31" ref="linksrc=author_aff">
|
||
31
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Rusch+S&cauthor_id=29599784"
|
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ref="linksrc=author_name_link"
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||
data-ga-category="search"
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data-ga-action="author_link"
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data-ga-label="Stephan Rusch">Stephan Rusch</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Freiburg, Germany." href="#short-view-affiliation-1" ref="linksrc=author_aff">
|
||
1
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Savic+S&cauthor_id=29599784"
|
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ref="linksrc=author_name_link"
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data-ga-category="search"
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data-ga-action="author_link"
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data-ga-label="Sinisa Savic">Sinisa Savic</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Study Center for Primary Immunodeficiencies, Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Medical School, Paris, France." href="#short-view-affiliation-32" ref="linksrc=author_aff">
|
||
32
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Scarselli+A&cauthor_id=29599784"
|
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ref="linksrc=author_name_link"
|
||
data-ga-category="search"
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data-ga-label="Alessia Scarselli">Alessia Scarselli</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="University Department of Pediatrics, Bambino Gesù Children's Hospital IRCCS, Rome, Italy." href="#short-view-affiliation-11" ref="linksrc=author_aff">
|
||
11
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy." href="#short-view-affiliation-12" ref="linksrc=author_aff">
|
||
12
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Scheible+R&cauthor_id=29599784"
|
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ref="linksrc=author_name_link"
|
||
data-ga-category="search"
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data-ga-action="author_link"
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data-ga-label="Raphael Scheible">Raphael Scheible</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Freiburg, Germany." href="#short-view-affiliation-1" ref="linksrc=author_aff">
|
||
1
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Sediva+A&cauthor_id=29599784"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
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data-ga-action="author_link"
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data-ga-label="Anna Sediva">Anna Sediva</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Immunology, 2nd Faculty of Medicine Charles University and Motol University Hospital, Prague, Czechia." href="#short-view-affiliation-27" ref="linksrc=author_aff">
|
||
27
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Sharapova+SO&cauthor_id=29599784"
|
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ref="linksrc=author_name_link"
|
||
data-ga-category="search"
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data-ga-label="Svetlana O Sharapova">Svetlana O Sharapova</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Research Department, Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus." href="#short-view-affiliation-6" ref="linksrc=author_aff">
|
||
6
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Shcherbina+A&cauthor_id=29599784"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
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data-ga-action="author_link"
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||
data-ga-label="Anna Shcherbina">Anna Shcherbina</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Immunology, Research and Clinical Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russia." href="#short-view-affiliation-28" ref="linksrc=author_aff">
|
||
28
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Slatter+M&cauthor_id=29599784"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
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||
data-ga-action="author_link"
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||
data-ga-label="Mary Slatter">Mary Slatter</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy." href="#short-view-affiliation-12" ref="linksrc=author_aff">
|
||
12
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Soler-Palacin+P&cauthor_id=29599784"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
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||
data-ga-action="author_link"
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||
data-ga-label="Pere Soler-Palacin">Pere Soler-Palacin</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain." href="#short-view-affiliation-24" ref="linksrc=author_aff">
|
||
24
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Stanislas+A&cauthor_id=29599784"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
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||
data-ga-action="author_link"
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||
data-ga-label="Aurelie Stanislas">Aurelie Stanislas</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Biotherapy Department, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Children's Hospital, Paris, France." href="#short-view-affiliation-15" ref="linksrc=author_aff">
|
||
15
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Suarez+F&cauthor_id=29599784"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
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data-ga-action="author_link"
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||
data-ga-label="Felipe Suarez">Felipe Suarez</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="INSERM UMR 1163, Imagine Institute, Paris, France." href="#short-view-affiliation-23" ref="linksrc=author_aff">
|
||
23
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Tucci+F&cauthor_id=29599784"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
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data-ga-action="author_link"
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||
data-ga-label="Francesca Tucci">Francesca Tucci</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy." href="#short-view-affiliation-5" ref="linksrc=author_aff">
|
||
5
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Uhlmann+A&cauthor_id=29599784"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
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data-ga-action="author_link"
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||
data-ga-label="Annette Uhlmann">Annette Uhlmann</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Freiburg, Germany." href="#short-view-affiliation-1" ref="linksrc=author_aff">
|
||
1
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=van+Montfrans+J&cauthor_id=29599784"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
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data-ga-action="author_link"
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||
data-ga-label="Joris van Montfrans">Joris van Montfrans</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Wilhelmina Children's Hospital, Utrecht, Netherlands." href="#short-view-affiliation-34" ref="linksrc=author_aff">
|
||
34
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Warnatz+K&cauthor_id=29599784"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
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data-ga-action="author_link"
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||
data-ga-label="Klaus Warnatz">Klaus Warnatz</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Freiburg, Germany." href="#short-view-affiliation-1" ref="linksrc=author_aff">
|
||
1
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Williams+AP&cauthor_id=29599784"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Anthony Peter Williams">Anthony Peter Williams</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="NIHR Clinical Research Facility, University Hospital Southampton NHSFT, Southampton, United Kingdom." href="#short-view-affiliation-21" ref="linksrc=author_aff">
|
||
21
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Wood+P&cauthor_id=29599784"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
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data-ga-action="author_link"
|
||
data-ga-label="Phil Wood">Phil Wood</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Clinical Immunology and Allergy, St James's University Hospital, Leeds, United Kingdom." href="#short-view-affiliation-35" ref="linksrc=author_aff">
|
||
35
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Kracker+S&cauthor_id=29599784"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
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data-ga-action="author_link"
|
||
data-ga-label="Sven Kracker">Sven Kracker</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Laboratory of Human Lymphohematopoiesis, INSERM UMR 1163, Imagine Institute, Paris, France." href="#short-view-affiliation-16" ref="linksrc=author_aff">
|
||
16
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Paris Descartes-Sorbonne Paris Cité University, Paris, France." href="#short-view-affiliation-17" ref="linksrc=author_aff">
|
||
17
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Condliffe+AM&cauthor_id=29599784"
|
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ref="linksrc=author_name_link"
|
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data-ga-category="search"
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data-ga-action="author_link"
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data-ga-label="Alison Mary Condliffe">Alison Mary Condliffe</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Infection, Immunity and Cardiovascular Science, University of Sheffield, Sheffield, United Kingdom." href="#short-view-affiliation-36" ref="linksrc=author_aff">
|
||
36
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Ehl+S&cauthor_id=29599784"
|
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ref="linksrc=author_name_link"
|
||
data-ga-category="search"
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data-ga-action="author_link"
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||
data-ga-label="Stephan Ehl">Stephan Ehl</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Freiburg, Germany." href="#short-view-affiliation-1" ref="linksrc=author_aff">
|
||
1
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Pediatrics and Adolescent Medicine, Medical Center - University of Freiburg, Freiburg, Germany." href="#short-view-affiliation-2" ref="linksrc=author_aff">
|
||
2
|
||
</a></sup></span>
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="affiliations">
|
||
<h3 class="title">
|
||
Affiliations
|
||
</h3>
|
||
<ul class="item-list">
|
||
|
||
<li data-affiliation-id="short-view-affiliation-1"
|
||
id="short-view-affiliation-1"
|
||
><sup class="key">1</sup> Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Freiburg, Germany.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-2"
|
||
id="short-view-affiliation-2"
|
||
><sup class="key">2</sup> Department of Pediatrics and Adolescent Medicine, Medical Center - University of Freiburg, Freiburg, Germany.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-3"
|
||
id="short-view-affiliation-3"
|
||
><sup class="key">3</sup> Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-4"
|
||
id="short-view-affiliation-4"
|
||
><sup class="key">4</sup> Research Center for Immunodeficiencies, Pediatric Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-5"
|
||
id="short-view-affiliation-5"
|
||
><sup class="key">5</sup> San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-6"
|
||
id="short-view-affiliation-6"
|
||
><sup class="key">6</sup> Research Department, Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-7"
|
||
id="short-view-affiliation-7"
|
||
><sup class="key">7</sup> Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-8"
|
||
id="short-view-affiliation-8"
|
||
><sup class="key">8</sup> Division of Pediatric Allergy/Immunology, Marmara University, Istanbul, Turkey.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-9"
|
||
id="short-view-affiliation-9"
|
||
><sup class="key">9</sup> Cambridge Centre for Lung Defense, Papworth Hospital, Cambridge, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-10"
|
||
id="short-view-affiliation-10"
|
||
><sup class="key">10</sup> Institute of Immunity and Transplantation, Royal Free Hospital, London, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-11"
|
||
id="short-view-affiliation-11"
|
||
><sup class="key">11</sup> University Department of Pediatrics, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-12"
|
||
id="short-view-affiliation-12"
|
||
><sup class="key">12</sup> Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-13"
|
||
id="short-view-affiliation-13"
|
||
><sup class="key">13</sup> Department of Paediatric Immunology, Newcastle upon Tyne Hospital NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-14"
|
||
id="short-view-affiliation-14"
|
||
><sup class="key">14</sup> Internal Medicine, University Hospital of Saint-Etienne, Saint-Etienne, France.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-15"
|
||
id="short-view-affiliation-15"
|
||
><sup class="key">15</sup> Biotherapy Department, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Children's Hospital, Paris, France.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-16"
|
||
id="short-view-affiliation-16"
|
||
><sup class="key">16</sup> Laboratory of Human Lymphohematopoiesis, INSERM UMR 1163, Imagine Institute, Paris, France.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-17"
|
||
id="short-view-affiliation-17"
|
||
><sup class="key">17</sup> Paris Descartes-Sorbonne Paris Cité University, Paris, France.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-18"
|
||
id="short-view-affiliation-18"
|
||
><sup class="key">18</sup> Department of Clinical Immunology, Addenbrookes Hospital, Cambridge, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-19"
|
||
id="short-view-affiliation-19"
|
||
><sup class="key">19</sup> Department of Medicine, University of Cambridge, Cambridge, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-20"
|
||
id="short-view-affiliation-20"
|
||
><sup class="key">20</sup> Regional Immunology Service, The Royal Hospitals & Queen's University, Belfast, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-21"
|
||
id="short-view-affiliation-21"
|
||
><sup class="key">21</sup> NIHR Clinical Research Facility, University Hospital Southampton NHSFT, Southampton, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-22"
|
||
id="short-view-affiliation-22"
|
||
><sup class="key">22</sup> Department of Pediatric Immunology, Hematology and Rheumatology, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Children's Hospital, Paris, France.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-23"
|
||
id="short-view-affiliation-23"
|
||
><sup class="key">23</sup> INSERM UMR 1163, Imagine Institute, Paris, France.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-24"
|
||
id="short-view-affiliation-24"
|
||
><sup class="key">24</sup> Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-25"
|
||
id="short-view-affiliation-25"
|
||
><sup class="key">25</sup> Immunodeficiency Centre for Wales, University Hospital of Wales, Cardiff, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-26"
|
||
id="short-view-affiliation-26"
|
||
><sup class="key">26</sup> French National Reference Center for Primary Immune Deficiencies (CEREDIH), Necker Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-27"
|
||
id="short-view-affiliation-27"
|
||
><sup class="key">27</sup> Department of Immunology, 2nd Faculty of Medicine Charles University and Motol University Hospital, Prague, Czechia.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-28"
|
||
id="short-view-affiliation-28"
|
||
><sup class="key">28</sup> Department of Immunology, Research and Clinical Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russia.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-29"
|
||
id="short-view-affiliation-29"
|
||
><sup class="key">29</sup> Sección de Infectologıa, Rheumatología and Inmunodeficiencias, Unidad de Pediatria, Hospital Virgen del Rocıo, Instituto de Biomedicina de Sevilla (IBiS), Sevilla, Spain.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-30"
|
||
id="short-view-affiliation-30"
|
||
><sup class="key">30</sup> Laboratory of Immunogenetics of Pediatric Autoimmunity, INSERM UMR 1163, Imagine Institute, Paris, France.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-31"
|
||
id="short-view-affiliation-31"
|
||
><sup class="key">31</sup> Division of Immunology, University Children's Hospital Zurich and Children's Research Centre, University Zurich, Zurich, Switzerland.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-32"
|
||
id="short-view-affiliation-32"
|
||
><sup class="key">32</sup> Study Center for Primary Immunodeficiencies, Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Medical School, Paris, France.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-33"
|
||
id="short-view-affiliation-33"
|
||
><sup class="key">33</sup> Laboratory of Lymphocyte Activation and Susceptibility to EBV Infection, INSERM UMR 1163, Imagine Institute, Paris, France.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-34"
|
||
id="short-view-affiliation-34"
|
||
><sup class="key">34</sup> Wilhelmina Children's Hospital, Utrecht, Netherlands.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-35"
|
||
id="short-view-affiliation-35"
|
||
><sup class="key">35</sup> Department of Clinical Immunology and Allergy, St James's University Hospital, Leeds, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-36"
|
||
id="short-view-affiliation-36"
|
||
><sup class="key">36</sup> Department of Infection, Immunity and Cardiovascular Science, University of Sheffield, Sheffield, United Kingdom.</li>
|
||
|
||
</ul>
|
||
</div>
|
||
|
||
|
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PMID:
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<strong class="current-id" title="PubMed ID">29599784</strong>
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DOI:
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ref="linksrc=article_id_link&article_id=10.3389/fimmu.2018.00543&id_type=DOI"
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10.3389/fimmu.2018.00543
|
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<p>
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Activated phosphoinositide 3-kinase (PI3K) δ Syndrome (APDS), caused by autosomal dominant mutations in <i>PIK3CD</i> (APDS1) or <i>PIK3R1</i> (APDS2), is a heterogeneous primary immunodeficiency. While initial cohort-descriptions summarized the spectrum of clinical and immunological manifestations, questions about long-term disease evolution and response to therapy remain. The prospective European Society for Immunodeficiencies (ESID)-APDS registry aims to characterize the disease course, identify outcome predictors, and evaluate treatment responses. So far, 77 patients have been recruited (51 APDS1, 26 APDS2). Analysis of disease evolution in the first 68 patients pinpoints the early occurrence of recurrent respiratory infections followed by chronic lymphoproliferation, gastrointestinal manifestations, and cytopenias. Although most manifestations occur by age 15, adult-onset and asymptomatic courses were documented. Bronchiectasis was observed in 24/40 APDS1 patients who received a CT-scan compared with 4/15 APDS2 patients. By age 20, half of the patients had received at least one immunosuppressant, but 2-3 lines of immunosuppressive therapy were not unusual before age 10. Response to rapamycin was rated by physician visual analog scale as good in 10, moderate in 9, and poor in 7. Lymphoproliferation showed the best response (8 complete, 11 partial, 6 no remission), while bowel inflammation (3 complete, 3 partial, 9 no remission) and cytopenia (3 complete, 2 partial, 9 no remission) responded less well. Hence, non-lymphoproliferative manifestations should be a key target for novel therapies. This report from the ESID-APDS registry provides comprehensive baseline documentation for a growing cohort that will be followed prospectively to establish prognostic factors and identify patients for treatment studies.
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<strong class="sub-title">
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Keywords:
|
||
</strong>
|
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|
||
PIK3CD; PIK3R1; activated phosphoinositide 3-kinase δ syndrome; natural history; rapamycin; registry.
|
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</p>
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<div class="figures" id="figures">
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Figures
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src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c317/5863269/a29ebfb6fcd2/fimmu-09-00543-g001.gif"
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<div class="figure-caption-contents"><b> (A) </b> Incidence of infections in…</div>
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<div class="figure-caption-contents"><b> (A) </b> Incidence of infections in APDS1 and APDS2 patients. <b> (B) </b> Incidence of manifestations…</div>
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<div class="figure-caption-contents"><b>(A)</b> Incidence of infections in APDS1 and APDS2 patients.
|
||
<b>(B)</b> Incidence of manifestations of immune dysregulation in
|
||
APDS1 and APDS2 patients. <b>(C)</b> Evolution of disease
|
||
manifestations over time. Information regarding age at onset available for:
|
||
respiratory infections <i>n</i> = 62/65,
|
||
lymphoproliferation <i>n</i> = 59/59,
|
||
gastrointestinal manifestations
|
||
<i>n</i> = 33/35, cytopenia
|
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<i>n</i> = 20/21 patients.
|
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<b>(D)</b> Diagram showing the different types of benign
|
||
lymphoproliferative manifestations. <b>(E)</b> Diagram showing
|
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the different blood lineages affected in patients with cytopenias.</div>
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<p> Figure 2 </p>
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</strong>
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<div class="figure-caption-contents"><b> (A) </b> Use of treatment modalities…</div>
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<strong class="figure-label">
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<p> Figure 2 </p>
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</strong>
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|
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<div class="figure-caption-contents"><b> (A) </b> Use of treatment modalities over time. IGRT, immunoglobulin-replacement-treatment; IS, immunosuppressive drug; HSCT,…</div>
|
||
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|
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</div>
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<figcaption id="figure-caption-1" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
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<strong class="figure-label">
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Figure 2
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><b>(A)</b> Use of treatment modalities over time. IGRT,
|
||
immunoglobulin-replacement-treatment; IS, immunosuppressive drug; HSCT,
|
||
hematopoietic stem cell transplantation. Information regarding age at first
|
||
therapy available for: IGRT <i>n</i> = 28/44,
|
||
steroid therapy <i>n</i> = 31/31, IS therapy
|
||
<i>n</i> = 35/36,
|
||
HSCT = 8/8. <b>(B)</b> Number of lines of
|
||
immunosuppressive treatments (steroids, immunosuppressive drugs, rituximab) by
|
||
the time of registration; red: patients who had undergone HSCT by the time of
|
||
registration. <b>(C)</b> Response to rapamycin treatment.
|
||
<i>White</i>: complete response; <i>gray</i>: partial
|
||
response; <i>black</i>: no response; <i>red</i>: worsened
|
||
or new manifestation; <i>boxes with a diagonal</i>: manifestation not
|
||
present in this patient. CR, complete remission; PR, partial remission.
|
||
Rapamycin stopped because of: *non-compliance, °inefficiency,
|
||
<sup>^</sup>side effects, <sup>§</sup>clinical trial.
|
||
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<span class="docsum-authors full-authors">Lau A, Avery DT, Jackson K, Lenthall H, Volpi S, Brigden H, Russell AJ, Bier J, Reed JH, Smart JM, Cole T, Choo S, Gray PE, Berglund LJ, Hsu P, Wong M, O'Sullivan M, Boztug K, Meyts I, Uzel G, Notarangelo LD, Brink R, Goodnow CC, Tangye SG, Deenick EK.</span>
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Lucas CL, Kuehn HS, Zhao F, Niemela JE, Deenick EK, Palendira U, et al. Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110delta result in T cell senescence and human immunodeficiency. Nat Immunol (2014) 15(1):88–97.10.1038/ni.2771
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<div id="mesh-terms" class="mesh-terms keywords-section">
|
||
<h2 class="title">
|
||
MeSH terms
|
||
</h2>
|
||
|
||
<ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword Adolescent"
|
||
tabindex="0"
|
||
aria-controls="keyword-actions-mesh-terms-0"
|
||
aria-expanded="false"
|
||
data-pinger-ignore>
|
||
Adolescent
|
||
</button><div id="keyword-actions-mesh-terms-0"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
||
hidden
|
||
aria-label="Dropdown menu for keyword Adolescent"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Adolescent%22%5BMeSH%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22Adolescent%22%5BMeSH%5D&sort=date&sort_order=desc"
|
||
ref="linksrc=search_in_pubmed_keyword_link&mesh="Adolescent"[MeSH]"
|
||
data-ga-category="search"
|
||
data-ga-action="mesh_term"
|
||
data-ga-label="Adolescent">
|
||
Search in PubMed
|
||
</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
||
ref="linksrc=search_in_mesh_link"
|
||
href="https://www.ncbi.nlm.nih.gov/mesh?term=Adolescent"
|
||
data-ga-category="search_mesh"
|
||
data-ga-action="mesh_term_link"
|
||
data-ga-label="Adolescent">
|
||
Search in MeSH
|
||
</a></li><li><a class="add-to-search-link dropdown-block-link"
|
||
ref="linksrc=add_to_search_link"
|
||
role="button"
|
||
data-search-term=""Adolescent"[MeSH]"
|
||
data-ga-category="search"
|
||
data-ga-action="add_to_search"
|
||
data-ga-label=""Adolescent"[MeSH]"
|
||
href="#">
|
||
Add to Search
|
||
</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword Adult"
|
||
tabindex="0"
|
||
aria-controls="keyword-actions-mesh-terms-1"
|
||
aria-expanded="false"
|
||
data-pinger-ignore>
|
||
Adult
|
||
</button><div id="keyword-actions-mesh-terms-1"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
||
hidden
|
||
aria-label="Dropdown menu for keyword Adult"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Adult%22%5BMeSH%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22Adult%22%5BMeSH%5D&sort=date&sort_order=desc"
|
||
ref="linksrc=search_in_pubmed_keyword_link&mesh="Adult"[MeSH]"
|
||
data-ga-category="search"
|
||
data-ga-action="mesh_term"
|
||
data-ga-label="Adult">
|
||
Search in PubMed
|
||
</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
||
ref="linksrc=search_in_mesh_link"
|
||
href="https://www.ncbi.nlm.nih.gov/mesh?term=Adult"
|
||
data-ga-category="search_mesh"
|
||
data-ga-action="mesh_term_link"
|
||
data-ga-label="Adult">
|
||
Search in MeSH
|
||
</a></li><li><a class="add-to-search-link dropdown-block-link"
|
||
ref="linksrc=add_to_search_link"
|
||
role="button"
|
||
data-search-term=""Adult"[MeSH]"
|
||
data-ga-category="search"
|
||
data-ga-action="add_to_search"
|
||
data-ga-label=""Adult"[MeSH]"
|
||
href="#">
|
||
Add to Search
|
||
</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword Child"
|
||
tabindex="0"
|
||
aria-controls="keyword-actions-mesh-terms-2"
|
||
aria-expanded="false"
|
||
data-pinger-ignore>
|
||
Child
|
||
</button><div id="keyword-actions-mesh-terms-2"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
||
hidden
|
||
aria-label="Dropdown menu for keyword Child"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Child%22%5BMeSH%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22Child%22%5BMeSH%5D&sort=date&sort_order=desc"
|
||
ref="linksrc=search_in_pubmed_keyword_link&mesh="Child"[MeSH]"
|
||
data-ga-category="search"
|
||
data-ga-action="mesh_term"
|
||
data-ga-label="Child">
|
||
Search in PubMed
|
||
</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
||
ref="linksrc=search_in_mesh_link"
|
||
href="https://www.ncbi.nlm.nih.gov/mesh?term=Child"
|
||
data-ga-category="search_mesh"
|
||
data-ga-action="mesh_term_link"
|
||
data-ga-label="Child">
|
||
Search in MeSH
|
||
</a></li><li><a class="add-to-search-link dropdown-block-link"
|
||
ref="linksrc=add_to_search_link"
|
||
role="button"
|
||
data-search-term=""Child"[MeSH]"
|
||
data-ga-category="search"
|
||
data-ga-action="add_to_search"
|
||
data-ga-label=""Child"[MeSH]"
|
||
href="#">
|
||
Add to Search
|
||
</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword Child, Preschool"
|
||
tabindex="0"
|
||
aria-controls="keyword-actions-mesh-terms-3"
|
||
aria-expanded="false"
|
||
data-pinger-ignore>
|
||
Child, Preschool
|
||
</button><div id="keyword-actions-mesh-terms-3"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
||
hidden
|
||
aria-label="Dropdown menu for keyword Child, Preschool"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Child%2C+Preschool%22%5BMeSH%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22Child%2C+Preschool%22%5BMeSH%5D&sort=date&sort_order=desc"
|
||
ref="linksrc=search_in_pubmed_keyword_link&mesh="Child, Preschool"[MeSH]"
|
||
data-ga-category="search"
|
||
data-ga-action="mesh_term"
|
||
data-ga-label="Child, Preschool">
|
||
Search in PubMed
|
||
</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
||
ref="linksrc=search_in_mesh_link"
|
||
href="https://www.ncbi.nlm.nih.gov/mesh?term=Child%2C+Preschool"
|
||
data-ga-category="search_mesh"
|
||
data-ga-action="mesh_term_link"
|
||
data-ga-label="Child, Preschool">
|
||
Search in MeSH
|
||
</a></li><li><a class="add-to-search-link dropdown-block-link"
|
||
ref="linksrc=add_to_search_link"
|
||
role="button"
|
||
data-search-term=""Child, Preschool"[MeSH]"
|
||
data-ga-category="search"
|
||
data-ga-action="add_to_search"
|
||
data-ga-label=""Child, Preschool"[MeSH]"
|
||
href="#">
|
||
Add to Search
|
||
</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword Class I Phosphatidylinositol 3-Kinases"
|
||
tabindex="0"
|
||
aria-controls="keyword-actions-mesh-terms-4"
|
||
aria-expanded="false"
|
||
data-pinger-ignore>
|
||
Class I Phosphatidylinositol 3-Kinases
|
||
</button><div id="keyword-actions-mesh-terms-4"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
||
hidden
|
||
aria-label="Dropdown menu for keyword Class I Phosphatidylinositol 3-Kinases"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Class+I+Phosphatidylinositol+3-Kinases%22%5BMeSH%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22Class+I+Phosphatidylinositol+3-Kinases%22%5BMeSH%5D&sort=date&sort_order=desc"
|
||
ref="linksrc=search_in_pubmed_keyword_link&mesh="Class I Phosphatidylinositol 3-Kinases"[MeSH]"
|
||
data-ga-category="search"
|
||
data-ga-action="mesh_term"
|
||
data-ga-label="Class I Phosphatidylinositol 3-Kinases">
|
||
Search in PubMed
|
||
</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
||
ref="linksrc=search_in_mesh_link"
|
||
href="https://www.ncbi.nlm.nih.gov/mesh?term=Class+I+Phosphatidylinositol+3-Kinases"
|
||
data-ga-category="search_mesh"
|
||
data-ga-action="mesh_term_link"
|
||
data-ga-label="Class I Phosphatidylinositol 3-Kinases">
|
||
Search in MeSH
|
||
</a></li><li><a class="add-to-search-link dropdown-block-link"
|
||
ref="linksrc=add_to_search_link"
|
||
role="button"
|
||
data-search-term=""Class I Phosphatidylinositol 3-Kinases"[MeSH]"
|
||
data-ga-category="search"
|
||
data-ga-action="add_to_search"
|
||
data-ga-label=""Class I Phosphatidylinositol 3-Kinases"[MeSH]"
|
||
href="#">
|
||
Add to Search
|
||
</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword Europe"
|
||
tabindex="0"
|
||
aria-controls="keyword-actions-mesh-terms-5"
|
||
aria-expanded="false"
|
||
data-pinger-ignore>
|
||
Europe
|
||
</button><div id="keyword-actions-mesh-terms-5"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
||
hidden
|
||
aria-label="Dropdown menu for keyword Europe"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Europe%22%5BMeSH%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22Europe%22%5BMeSH%5D&sort=date&sort_order=desc"
|
||
ref="linksrc=search_in_pubmed_keyword_link&mesh="Europe"[MeSH]"
|
||
data-ga-category="search"
|
||
data-ga-action="mesh_term"
|
||
data-ga-label="Europe">
|
||
Search in PubMed
|
||
</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
||
ref="linksrc=search_in_mesh_link"
|
||
href="https://www.ncbi.nlm.nih.gov/mesh?term=Europe"
|
||
data-ga-category="search_mesh"
|
||
data-ga-action="mesh_term_link"
|
||
data-ga-label="Europe">
|
||
Search in MeSH
|
||
</a></li><li><a class="add-to-search-link dropdown-block-link"
|
||
ref="linksrc=add_to_search_link"
|
||
role="button"
|
||
data-search-term=""Europe"[MeSH]"
|
||
data-ga-category="search"
|
||
data-ga-action="add_to_search"
|
||
data-ga-label=""Europe"[MeSH]"
|
||
href="#">
|
||
Add to Search
|
||
</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword Humans"
|
||
tabindex="0"
|
||
aria-controls="keyword-actions-mesh-terms-6"
|
||
aria-expanded="false"
|
||
data-pinger-ignore>
|
||
Humans
|
||
</button><div id="keyword-actions-mesh-terms-6"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
||
hidden
|
||
aria-label="Dropdown menu for keyword Humans"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc"
|
||
ref="linksrc=search_in_pubmed_keyword_link&mesh="Humans"[MeSH]"
|
||
data-ga-category="search"
|
||
data-ga-action="mesh_term"
|
||
data-ga-label="Humans">
|
||
Search in PubMed
|
||
</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
||
ref="linksrc=search_in_mesh_link"
|
||
href="https://www.ncbi.nlm.nih.gov/mesh?term=Humans"
|
||
data-ga-category="search_mesh"
|
||
data-ga-action="mesh_term_link"
|
||
data-ga-label="Humans">
|
||
Search in MeSH
|
||
</a></li><li><a class="add-to-search-link dropdown-block-link"
|
||
ref="linksrc=add_to_search_link"
|
||
role="button"
|
||
data-search-term=""Humans"[MeSH]"
|
||
data-ga-category="search"
|
||
data-ga-action="add_to_search"
|
||
data-ga-label=""Humans"[MeSH]"
|
||
href="#">
|
||
Add to Search
|
||
</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major"
|
||
aria-label="Toggle dropdown menu for keyword Immunologic Deficiency Syndromes / drug therapy*"
|
||
tabindex="0"
|
||
aria-controls="keyword-actions-mesh-terms-major-7"
|
||
aria-expanded="false"
|
||
data-pinger-ignore>
|
||
Immunologic Deficiency Syndromes / drug therapy*
|
||
</button><div id="keyword-actions-mesh-terms-major-7"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
||
hidden
|
||
aria-label="Dropdown menu for keyword Immunologic Deficiency Syndromes / drug therapy*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Immunologic+Deficiency+Syndromes%2Fdrug+therapy%22%5BMAJR%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22Immunologic+Deficiency+Syndromes%2Fdrug+therapy%22%5BMAJR%5D&sort=date&sort_order=desc"
|
||
ref="linksrc=search_in_pubmed_keyword_link&mesh="Immunologic Deficiency Syndromes/drug therapy"[MAJR]"
|
||
data-ga-category="search"
|
||
data-ga-action="mesh_term"
|
||
data-ga-label="Immunologic Deficiency Syndromes / drug therapy*">
|
||
Search in PubMed
|
||
</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
||
ref="linksrc=search_in_mesh_link"
|
||
href="https://www.ncbi.nlm.nih.gov/mesh?term=Immunologic+Deficiency+Syndromes"
|
||
data-ga-category="search_mesh"
|
||
data-ga-action="mesh_term_link"
|
||
data-ga-label="Immunologic Deficiency Syndromes / drug therapy*">
|
||
Search in MeSH
|
||
</a></li><li><a class="add-to-search-link dropdown-block-link"
|
||
ref="linksrc=add_to_search_link"
|
||
role="button"
|
||
data-search-term=""Immunologic Deficiency Syndromes/drug therapy"[MAJR]"
|
||
data-ga-category="search"
|
||
data-ga-action="add_to_search"
|
||
data-ga-label=""Immunologic Deficiency Syndromes/drug therapy"[MAJR]"
|
||
href="#">
|
||
Add to Search
|
||
</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major"
|
||
aria-label="Toggle dropdown menu for keyword Immunosuppressive Agents / therapeutic use*"
|
||
tabindex="0"
|
||
aria-controls="keyword-actions-mesh-terms-major-8"
|
||
aria-expanded="false"
|
||
data-pinger-ignore>
|
||
Immunosuppressive Agents / therapeutic use*
|
||
</button><div id="keyword-actions-mesh-terms-major-8"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
||
hidden
|
||
aria-label="Dropdown menu for keyword Immunosuppressive Agents / therapeutic use*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Immunosuppressive+Agents%2Ftherapeutic+use%22%5BMAJR%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22Immunosuppressive+Agents%2Ftherapeutic+use%22%5BMAJR%5D&sort=date&sort_order=desc"
|
||
ref="linksrc=search_in_pubmed_keyword_link&mesh="Immunosuppressive Agents/therapeutic use"[MAJR]"
|
||
data-ga-category="search"
|
||
data-ga-action="mesh_term"
|
||
data-ga-label="Immunosuppressive Agents / therapeutic use*">
|
||
Search in PubMed
|
||
</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
||
ref="linksrc=search_in_mesh_link"
|
||
href="https://www.ncbi.nlm.nih.gov/mesh?term=Immunosuppressive+Agents"
|
||
data-ga-category="search_mesh"
|
||
data-ga-action="mesh_term_link"
|
||
data-ga-label="Immunosuppressive Agents / therapeutic use*">
|
||
Search in MeSH
|
||
</a></li><li><a class="add-to-search-link dropdown-block-link"
|
||
ref="linksrc=add_to_search_link"
|
||
role="button"
|
||
data-search-term=""Immunosuppressive Agents/therapeutic use"[MAJR]"
|
||
data-ga-category="search"
|
||
data-ga-action="add_to_search"
|
||
data-ga-label=""Immunosuppressive Agents/therapeutic use"[MAJR]"
|
||
href="#">
|
||
Add to Search
|
||
</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword Middle Aged"
|
||
tabindex="0"
|
||
aria-controls="keyword-actions-mesh-terms-9"
|
||
aria-expanded="false"
|
||
data-pinger-ignore>
|
||
Middle Aged
|
||
</button><div id="keyword-actions-mesh-terms-9"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
||
hidden
|
||
aria-label="Dropdown menu for keyword Middle Aged"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Middle+Aged%22%5BMeSH%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22Middle+Aged%22%5BMeSH%5D&sort=date&sort_order=desc"
|
||
ref="linksrc=search_in_pubmed_keyword_link&mesh="Middle Aged"[MeSH]"
|
||
data-ga-category="search"
|
||
data-ga-action="mesh_term"
|
||
data-ga-label="Middle Aged">
|
||
Search in PubMed
|
||
</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
||
ref="linksrc=search_in_mesh_link"
|
||
href="https://www.ncbi.nlm.nih.gov/mesh?term=Middle+Aged"
|
||
data-ga-category="search_mesh"
|
||
data-ga-action="mesh_term_link"
|
||
data-ga-label="Middle Aged">
|
||
Search in MeSH
|
||
</a></li><li><a class="add-to-search-link dropdown-block-link"
|
||
ref="linksrc=add_to_search_link"
|
||
role="button"
|
||
data-search-term=""Middle Aged"[MeSH]"
|
||
data-ga-category="search"
|
||
data-ga-action="add_to_search"
|
||
data-ga-label=""Middle Aged"[MeSH]"
|
||
href="#">
|
||
Add to Search
|
||
</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword Primary Immunodeficiency Diseases"
|
||
tabindex="0"
|
||
aria-controls="keyword-actions-mesh-terms-10"
|
||
aria-expanded="false"
|
||
data-pinger-ignore>
|
||
Primary Immunodeficiency Diseases
|
||
</button><div id="keyword-actions-mesh-terms-10"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
||
hidden
|
||
aria-label="Dropdown menu for keyword Primary Immunodeficiency Diseases"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Primary+Immunodeficiency+Diseases%22%5BMeSH%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22Primary+Immunodeficiency+Diseases%22%5BMeSH%5D&sort=date&sort_order=desc"
|
||
ref="linksrc=search_in_pubmed_keyword_link&mesh="Primary Immunodeficiency Diseases"[MeSH]"
|
||
data-ga-category="search"
|
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data-pinger-ignore>
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Registries*
|
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</button><div id="keyword-actions-mesh-terms-major-11"
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aria-label="Dropdown menu for keyword Registries*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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Sirolimus / therapeutic use*
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aria-label="Dropdown menu for keyword Sirolimus / therapeutic use*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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data-href="/?term=%22Sirolimus%2Ftherapeutic+use%22%5BMAJR%5D&sort=date&sort_order=desc"
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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Societies, Medical
|
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</button><div id="keyword-actions-mesh-terms-13"
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aria-label="Dropdown menu for keyword Societies, Medical"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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Young Adult
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</button><div id="keyword-actions-mesh-terms-14"
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class="keyword-actions-dropdown dropdown dropdown-container"
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hidden
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aria-label="Dropdown menu for keyword Young Adult"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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</a></li></ul></div></div></div></li></ul>
|
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</div>
|
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|
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|
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|
||
|
||
|
||
<div id="substances" class="substances keywords-section">
|
||
<h2 class="title">
|
||
Substances
|
||
</h2>
|
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|
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<ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword Immunosuppressive Agents"
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Immunosuppressive Agents
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class="keyword-actions-dropdown dropdown dropdown-container"
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aria-label="Dropdown menu for keyword Immunosuppressive Agents"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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Search in PubMed
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Search in MeSH
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data-ga-category="search"
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Add to Search
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword Class I Phosphatidylinositol 3-Kinases"
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tabindex="0"
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data-pinger-ignore>
|
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Class I Phosphatidylinositol 3-Kinases
|
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</button><div id="keyword-actions-substances-1"
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class="keyword-actions-dropdown dropdown dropdown-container"
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hidden
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aria-label="Dropdown menu for keyword Class I Phosphatidylinositol 3-Kinases"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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data-href="/?term=%22Class+I+Phosphatidylinositol+3-Kinases%22%5Bnm%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&keyword="Class I Phosphatidylinositol 3-Kinases"[nm]"
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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Search in MeSH
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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Add to Search
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword Sirolimus"
|
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tabindex="0"
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aria-controls="keyword-actions-substances-2"
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aria-expanded="false"
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data-pinger-ignore>
|
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Sirolimus
|
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</button><div id="keyword-actions-substances-2"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
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aria-label="Dropdown menu for keyword Sirolimus"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
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href="/?term=%22Sirolimus%22%5Bnm%5D&sort=date&sort_order=desc"
|
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data-href="/?term=%22Sirolimus%22%5Bnm%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&keyword="Sirolimus"[nm]"
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Sirolimus%22"
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data-ga-action="substance_link"
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data-ga-label="Sirolimus">
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Search in MeSH
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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ref="linksrc=add_to_search_link"
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role="button"
|
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data-search-term=""Sirolimus"[nm]"
|
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data-ga-category="search"
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data-ga-action="add_to_search"
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data-ga-label=""Sirolimus"[nm]"
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href="#">
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Add to Search
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</a></li></ul></div></div></div></li></ul>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
<div id="supplementary-concepts" class="supplementary-concepts keywords-section">
|
||
<h2 class="title">
|
||
Supplementary concepts
|
||
</h2>
|
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|
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<ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword Activated PI3K-delta Syndrome"
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tabindex="0"
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aria-expanded="false"
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data-pinger-ignore>
|
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Activated PI3K-delta Syndrome
|
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</button><div id="keyword-actions-supplementary-concepts-0"
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class="keyword-actions-dropdown dropdown dropdown-container"
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hidden
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aria-label="Dropdown menu for keyword Activated PI3K-delta Syndrome"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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href="/?term=%22Activated+PI3K-delta+Syndrome%22%5Bnm%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Activated+PI3K-delta+Syndrome%22%5Bnm%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&keyword="Activated PI3K-delta Syndrome"[nm]"
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Search in PubMed
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Search in MeSH
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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data-search-term=""Activated PI3K-delta Syndrome"[nm]"
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data-ga-category="search"
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Add to Search
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</a></li></ul></div></div></div></li></ul>
|
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</div>
|
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|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div id="related-links" class="related-links">
|
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<h2 class="title">
|
||
Related information
|
||
</h2>
|
||
|
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<ul class="related-links-list"><li><a title="PubMed links associated with Books" href="https://www.ncbi.nlm.nih.gov/books?linkname=pubmed_books_refs&from_uid=29599784"
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ref="log$=recordlinks&logdbfrom=pubmed&ncbi_uid=29599784&ordinalpos=1&linkpos=1">
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Cited in Books
|
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</a></li><li><a title="Related records in MedGen based on citations in GeneReviews and Medical Genetics Summaries" href="https://www.ncbi.nlm.nih.gov/medgen?linkname=pubmed_medgen_bookshelf_cited&from_uid=29599784"
|
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ref="log$=recordlinks&logdbfrom=pubmed&ncbi_uid=29599784&ordinalpos=1&linkpos=2">
|
||
MedGen (Bookshelf cited)
|
||
</a></li><li><a title="Related PubChem Compound via MeSH" href="https://www.ncbi.nlm.nih.gov/pccompound?linkname=pubmed_pccompound_mesh&from_uid=29599784"
|
||
ref="log$=recordlinks&logdbfrom=pubmed&ncbi_uid=29599784&ordinalpos=1&linkpos=3">
|
||
PubChem Compound (MeSH Keyword)
|
||
</a></li></ul>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
<div id="grants" class="grants">
|
||
<h2 class="title">
|
||
Grants and funding
|
||
</h2>
|
||
<div class="grants-list"><ul id="grants-head-list"><li class="grant-item"><a
|
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title="All articles for grant 206618/Z/17/Z/WT_/Wellcome Trust/United Kingdom"
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href="/?term=206618%2FZ%2F17%2FZ%2FWT_%2FWellcome+Trust%2FUnited+Kingdom%5BGrants+and+Funding%5D&sort=date&sort_order=desc"
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>
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206618/Z/17/Z/WT_/Wellcome Trust/United Kingdom
|
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</a></li></ul></div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div id="linkout" class="linkout">
|
||
<h2 class="title">
|
||
LinkOut - more resources
|
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</h2>
|
||
|
||
<ul class="linkout-list"><li><h3 class="linkout-category">Full Text Sources</h3><ul class="linkout-category-links"><li><a
|
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href="http://hdl.handle.net/10668/12286"
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target="_blank"
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rel="noopener"
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data-ga-label="Andalusian Health Repository - access to free full text"
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>
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Andalusian Health Repository - access to free full text
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</a></li><li><a
|
||
href="http://hdl.handle.net/10261/180501"
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