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||
User Guide
|
||
</a>
|
||
</span>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
</form>
|
||
|
||
|
||
<div id="article-page-header">
|
||
<div id="article-top-actions-bar" class="article-top-actions-bar">
|
||
<div class="inner-wrap">
|
||
<div class="actions-container">
|
||
<div class="return-to-search">
|
||
|
||
|
||
</div>
|
||
|
||
<div class="multiple-results-actions " role="region" aria-label="save, email, send to">
|
||
<button id="save-results-panel-trigger"
|
||
type="button"
|
||
class="save-results save-results-panel-trigger"
|
||
aria-expanded="false"
|
||
aria-controls="save-action-panel"
|
||
data-ga-category="save_share"
|
||
data-ga-action="save"
|
||
data-ga-label="open">
|
||
Save
|
||
</button><button id="email-results-panel-trigger"
|
||
type="button"
|
||
class="email-results email-results-panel-trigger"
|
||
aria-expanded="false"
|
||
aria-controls="email-action-panel"
|
||
data-ga-category="save_share"
|
||
data-ga-action="email"
|
||
data-ga-label="open">
|
||
Email
|
||
</button><div class="more-actions dropdown-block"><button id="more-actions-trigger"
|
||
type="button"
|
||
class="trigger more-actions-trigger"
|
||
ref="linksrc=show_moreactions_btn"
|
||
aria-label="Send to"
|
||
aria-controls="more-actions-dropdown">Send to</button><div id="more-actions-dropdown" class="dropdown dropdown-container" hidden><div class="content"><ul class="more-actions-links"><li><a class="clipboard-panel-trigger dropdown-block-link "
|
||
href="#"
|
||
role="button"
|
||
data-ga-category="save_share"
|
||
data-ga-action="clipboard"
|
||
data-ga-label="send">
|
||
Clipboard
|
||
</a></li><li><a role="button" class="dropdown-block-link bibliography-trigger-target" href="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F17640524%2F%23open-bibliography-panel">My Bibliography</a></li><li><a role="button" class="dropdown-block-link collections-trigger-target" href="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F17640524%2F%23open-collections-panel">Collections</a></li><li><a role="button" class="citation-manager-panel-trigger dropdown-block-link citation-manager-trigger-target" href="#">Citation manager</a></li></ul></div></div></div>
|
||
</div>
|
||
|
||
|
||
|
||
<div class="display-options" data-format-key="format"
|
||
data-default-format-value="abstract"
|
||
data-current-format-value="abstract" role="region">
|
||
<button
|
||
class="trigger usa-button"
|
||
title="Change format"
|
||
data-ga-category="display_options"
|
||
data-ga-action="display_options_dialog">
|
||
<span class="button-label">Display options</span>
|
||
</button>
|
||
|
||
<div class="dropdown" hidden>
|
||
<div class="title">
|
||
Display options
|
||
</div>
|
||
|
||
<div class="content">
|
||
|
||
<div class="format-container">
|
||
<span class="option-label">
|
||
Format
|
||
</span>
|
||
<select name="format" data-initial-value="abstract" aria-label="Display format" id="article-display-format">
|
||
<option value="abstract">Abstract</option>
|
||
|
||
<option value="pubmed">PubMed</option>
|
||
|
||
<option value="pmid">PMID</option>
|
||
|
||
</select>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="AubOTOXtpCX43K9ctul5fqxDDUYkY2WSRhVTwEqPZdKyXbf26NY7Jy3hbYGwRDuc">
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="article-panels-container" class="article-panels-container">
|
||
<div id="save-action-panel" class="save-action-panel action-panel" aria-hidden="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Save citation to file
|
||
</h2>
|
||
<form id="save-action-panel-form"
|
||
class="action-panel-content action-form"
|
||
action="/results-export-ids/"
|
||
data-by-search-action="/results-export-search-data/"
|
||
data-by-ids-action="/results-export-ids/"
|
||
method="post"
|
||
data-by-search-method="post"
|
||
data-by-ids-method="post">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="AubOTOXtpCX43K9ctul5fqxDDUYkY2WSRhVTwEqPZdKyXbf26NY7Jy3hbYGwRDuc">
|
||
|
||
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="save-action-format" class="action-panel-label">
|
||
Format:
|
||
</label>
|
||
<select id="save-action-format" name="results-format" class="action-panel-selector">
|
||
<option value="summary-text">Summary (text)</option>
|
||
<option value="pubmed-text">PubMed</option>
|
||
<option value="pmid">PMID</option>
|
||
<option value="abstract">Abstract (text)</option>
|
||
<option value="csv">CSV</option>
|
||
</select>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Saving..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="save"
|
||
data-ga-label="save">
|
||
Create file
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Save citations to file' panel"
|
||
ref="linksrc=close_save_panel"
|
||
aria-controls="save-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="save"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div id="email-action-panel"
|
||
class="email-action-panel action-panel"
|
||
aria-hidden="true"
|
||
data-recaptcha-script-url="https://www.recaptcha.net/recaptcha/enterprise.js?render=explicit&onload=onloadCaptchaCallback"
|
||
data-recaptcha-enabled="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Email citation
|
||
</h2>
|
||
<form id="email-action-panel-form"
|
||
class="action-panel-content action-form"
|
||
action="/send-email/"
|
||
data-by-search-action="/results-export-email-by-search-data/"
|
||
data-by-ids-action="/send-email/"
|
||
data-by-search-method="post"
|
||
data-by-ids-method="post"
|
||
method="post"
|
||
>
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="AubOTOXtpCX43K9ctul5fqxDDUYkY2WSRhVTwEqPZdKyXbf26NY7Jy3hbYGwRDuc">
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<span class="action-panel-label">
|
||
Subject:
|
||
</span>
|
||
<span class="email-subject" id="email-subject" aria-label="Email subject">1 selected item: 17640524 - PubMed</span>
|
||
<input type="hidden" name="email-subject" value="1 selected item: 17640524"/>
|
||
<input type="hidden" name="email-subject-hash" value="6d20e63b8b48897676daca2998db673df955d0e9d9d8eba51e85f5de15be8087"/>
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="email-to" class="action-panel-label required-field-asterisk">
|
||
To:
|
||
</label>
|
||
<input type="email" aria-label="Recipient Email Address" placeholder="email@example.com" id="email-to" class="email-to" pattern="^[a-zA-Z0-9_.+-]+@[a-zA-Z0-9-]+\.[a-zA-Z0-9-.]+$" maxlength="100" required>
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="email-from" class="action-panel-label">
|
||
From:
|
||
</label>
|
||
<input type="email" aria-label="Sender Email Address" placeholder="email@example.com" id="email-from" class="email-from" pattern="^[a-zA-Z0-9_.+-]+@[a-zA-Z0-9-]+\.[a-zA-Z0-9-.]+$" maxlength="256">
|
||
</div>
|
||
|
||
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="email-citation-format" class="action-panel-label">
|
||
Format:
|
||
</label>
|
||
<select id="email-citation-format" name="citation-format" class="action-panel-selector email-citation-format">
|
||
<option selected="selected" value="summary">Summary</option>
|
||
<option value="summary-text">Summary (text)</option>
|
||
<option value="abstract">Abstract</option>
|
||
<option value="abstract-text">Abstract (text)</option>
|
||
|
||
</select>
|
||
</div>
|
||
<div class="include-supplemental-container">
|
||
<input type="checkbox" aria-label="Include MeSH and other data" name="include-supplemental" id="email-include-supplemental" class="email-include-supplemental">
|
||
<label for="email-include-supplemental" class="email-include-supplemental-label">MeSH and other data</label>
|
||
</div>
|
||
|
||
|
||
|
||
<div class="form-field recaptcha ">
|
||
|
||
|
||
|
||
<div class="g-recaptcha" id="id-recaptcha" data-sitekey="6LfsWHMdAAAAAClKbtOpjQ2pMjgsGxvv7NdZW9uI"></div>
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
<div id="captcha-error-message" class="usa-input-error-message captcha-validation-message" role="alert"></div>
|
||
|
||
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Sending..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="email"
|
||
data-ga-label="send">
|
||
Send email
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Email citations' panel"
|
||
ref="linksrc=close_email_panel"
|
||
aria-controls="email-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="email"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
<input type="hidden" name="email-search-details" value="" />
|
||
<input type="hidden" name="email-search-details-hash" value="0e42663a6c3bd85498fcb88798998fed7bfdc45d457db35281e41afe13cc0524" />
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="collections-action-panel"
|
||
class="collections-action-panel action-panel in-progress-dots-panel"
|
||
aria-hidden="true"
|
||
data-collections-open-panel-enabled="false"
|
||
data-collections-open-panel-url-hash="#open-collections-panel">
|
||
<div class="inner-wrap">
|
||
<h3 class="action-panel-heading">
|
||
Add to Collections
|
||
</h3>
|
||
|
||
|
||
<form id="collections-action-panel-form"
|
||
class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
|
||
data-existing-collections-url="/list-existing-collections/"
|
||
data-add-to-existing-collection-url="/add-to-existing-collection/"
|
||
data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/"
|
||
data-get-article-ids-by-search-url="/get-article-ids-by-search/"
|
||
data-myncbi-max-collection-name-length="100"
|
||
data-add-to-collection-max-amount="1000"
|
||
data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="AubOTOXtpCX43K9ctul5fqxDDUYkY2WSRhVTwEqPZdKyXbf26NY7Jy3hbYGwRDuc">
|
||
|
||
|
||
|
||
<div class="choice-group" role="radiogroup">
|
||
<ul class="radio-group-items">
|
||
<li>
|
||
<input type="radio"
|
||
id="collections-action-panel-new"
|
||
class="collections-new"
|
||
name="collections"
|
||
value="new"
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="collections_radio_new">
|
||
<label for="collections-action-panel-new">Create a new collection</label>
|
||
</li>
|
||
<li>
|
||
<input type="radio"
|
||
id="collections-action-panel-existing"
|
||
class="collections-existing"
|
||
name="collections"
|
||
value="existing"
|
||
checked="true"
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="collections_radio_existing">
|
||
<label for="collections-action-panel-existing">Add to an existing collection</label>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
|
||
<div class="controls-wrapper">
|
||
<div class="action-panel-control-wrap new-collections-controls">
|
||
<label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk">
|
||
Name your collection:
|
||
</label>
|
||
<input
|
||
type="text"
|
||
name="add-to-new-collection"
|
||
id="collections-action-panel-add-to-new"
|
||
class="collections-action-add-to-new"
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"
|
||
maxlength="100"
|
||
data-ga-category="save_share"
|
||
data-ga-action="create_collection"
|
||
data-ga-label="non_favorties_collection">
|
||
<div class="collections-new-name-too-long usa-input-error-message selection-validation-message">
|
||
Name must be less than 100 characters
|
||
</div>
|
||
</div>
|
||
<div class="action-panel-control-wrap existing-collections-controls">
|
||
<label for="collections-action-panel-add-to-existing" class="action-panel-label">
|
||
Choose a collection:
|
||
</label>
|
||
<select id="collections-action-panel-add-to-existing"
|
||
class="action-panel-selector collections-action-add-to-existing"
|
||
data-ga-category="save_share"
|
||
data-ga-action="select_collection"
|
||
data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'">
|
||
</select>
|
||
<div class="collections-retry-load-on-error usa-input-error-message selection-validation-message">
|
||
Unable to load your collection due to an error<br>
|
||
<a href="#">Please try again</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Adding..."
|
||
data-pinger-ignore
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="add">
|
||
Add
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Add to Collections' panel"
|
||
ref="linksrc=close_collections_panel"
|
||
aria-controls="collections-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="bibliography-action-panel"
|
||
class="bibliography-action-panel action-panel in-progress-dots-panel"
|
||
aria-hidden="true"
|
||
data-bibliography-open-panel-enabled="false"
|
||
data-bibliography-open-panel-url-hash="#open-bibliography-panel">
|
||
<div class="inner-wrap">
|
||
<h3 class="action-panel-heading">
|
||
Add to My Bibliography
|
||
</h3>
|
||
<form id="bibliography-action-panel-form"
|
||
class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
|
||
data-add-to-bibliography-max-amount="100"
|
||
data-add-to-bibliography-batch-size="10"
|
||
data-bibliography-delegates-url="/list-bibliography-delegates/"
|
||
data-add-to-bibliography-url="/add-to-bibliography/"
|
||
data-get-article-ids-by-search-url="/get-article-ids-by-search/"
|
||
data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="AubOTOXtpCX43K9ctul5fqxDDUYkY2WSRhVTwEqPZdKyXbf26NY7Jy3hbYGwRDuc">
|
||
|
||
|
||
|
||
<div class="action-panel-control-wrap bibliographies-controls">
|
||
<div class="choice-group">
|
||
<ul class="bibliographies-action-add radio-group-items">
|
||
<li>
|
||
<input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/>
|
||
<label for="my-bibliography">My Bibliography</label>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message">
|
||
Unable to load your delegates due to an error<br>
|
||
<a href="#">Please try again</a>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Adding..."
|
||
data-pinger-ignore>
|
||
Add
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Add to bibliography' panel"
|
||
ref="linksrc=close_bibliography_panel"
|
||
aria-controls="bibliography-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="mybib"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true"
|
||
data-saved-search-open-panel-enabled="false"
|
||
data-saved-search-open-panel-url-hash="#open-saved-search-panel">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Your saved search
|
||
</h2>
|
||
|
||
<form id="saved-search-action-panel-form"
|
||
class="saved-search-action-panel-form action-panel-content action-form"
|
||
data-create-saved-search-url="/create-saved-search/"
|
||
data-try-search-terms-url="/try-search-term/"
|
||
data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="AubOTOXtpCX43K9ctul5fqxDDUYkY2WSRhVTwEqPZdKyXbf26NY7Jy3hbYGwRDuc">
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk">
|
||
Name of saved search:
|
||
</label>
|
||
<input maxlength="200"
|
||
type="text"
|
||
name="saved-search-name"
|
||
id="saved-search-name"
|
||
class="saved-search-name"
|
||
value=""
|
||
required
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/">
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-term" class="action-panel-label required-field-asterisk">
|
||
Search terms:
|
||
</label>
|
||
<textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea>
|
||
</div>
|
||
<div class="test-search-term-wrap">
|
||
<a href="#" class="try-search-term">Test search terms</a>
|
||
</div>
|
||
<div class="choice-group action-panel-extra-margin-top">
|
||
<span class="action-panel-label" id="fieldset-label">
|
||
Would you like email updates of new search results?
|
||
</span>
|
||
<fieldset id="saved-search-alert" aria-describedby="fieldset-label">
|
||
<legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend>
|
||
<ul class="radio-group-items">
|
||
<li>
|
||
<input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked>
|
||
<label for="saved-search-alert-yes" class="action-panel-label">Yes</label>
|
||
</li>
|
||
<li>
|
||
<input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no">
|
||
<label for="saved-search-alert-no" class="action-panel-label">No</label>
|
||
</li>
|
||
</ul>
|
||
</fieldset>
|
||
</div>
|
||
|
||
<div class="alert-schedule-wrap">
|
||
<div class="action-panel-control-wrap">
|
||
<label class="action-panel-label">
|
||
Email:
|
||
</label>
|
||
<span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span>
|
||
</div>
|
||
<div class="action-panel-control-wrap action-panel-extra-margin-top">
|
||
<label for="saved-search-frequency" class="action-panel-label">
|
||
Frequency:
|
||
</label>
|
||
<select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency">
|
||
<option value="monthly">Monthly</option>
|
||
<option value="weekly">Weekly</option>
|
||
<option value="daily">Daily</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap saved-search-monthly-additional">
|
||
<label for="saved-search-monthly-on-day" class="action-panel-label">
|
||
Which day?
|
||
</label>
|
||
<select id="saved-search-monthly-on-day" class="no-border-panel-selector">
|
||
<option value="Sunday">The first Sunday</option>
|
||
<option value="Monday">The first Monday</option>
|
||
<option value="Tuesday">The first Tuesday</option>
|
||
<option value="Wednesday">The first Wednesday</option>
|
||
<option value="Thursday">The first Thursday</option>
|
||
<option value="Friday">The first Friday</option>
|
||
<option value="Saturday">The first Saturday</option>
|
||
<option value="day">The first day</option>
|
||
<option value="weekday">The first weekday</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap saved-search-weekly-additional">
|
||
<label for="saved-search-weekly-on-day" class="action-panel-label">
|
||
Which day?
|
||
</label>
|
||
<select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day">
|
||
<option value="Sunday">Sunday</option>
|
||
<option value="Monday">Monday</option>
|
||
<option value="Tuesday">Tuesday</option>
|
||
<option value="Wednesday">Wednesday</option>
|
||
<option value="Thursday">Thursday</option>
|
||
<option value="Friday">Friday</option>
|
||
<option value="Saturday">Saturday</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-report" class="action-panel-label">
|
||
Report format:
|
||
</label>
|
||
<select id="saved-search-report" class="no-border-panel-selector saved-search-report">
|
||
<option value="DocSum">Summary</option>
|
||
<option value="DocSumText">Summary (text)</option>
|
||
<option value="Abstract">Abstract</option>
|
||
<option value="AbstractText">Abstract (text)</option>
|
||
<option value="MEDLINE">PubMed</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-amount" class="action-panel-label">
|
||
Send at most:
|
||
</label>
|
||
<select id="saved-search-amount" class="no-border-panel-selector saved-search-amount">
|
||
<option value="1">1 item</option>
|
||
<option value="5" selected>5 items</option>
|
||
<option value="10">10 items</option>
|
||
<option value="20">20 items</option>
|
||
<option value="50">50 items</option>
|
||
<option value="100">100 items</option>
|
||
<option value="200">200 items</option>
|
||
</select>
|
||
</div>
|
||
<div>
|
||
<input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result">
|
||
<label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox">
|
||
Send even when there aren't any new results
|
||
</label>
|
||
</div>
|
||
<div class="action-panel-control-wrap option-text-in-email-wrap">
|
||
<label for="saved-search-email-text" class="action-panel-label">
|
||
Optional text in email:
|
||
</label>
|
||
<textarea name="saved-search-email-text"
|
||
id="saved-search-email-text"
|
||
class="saved-search-email-text"></textarea>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Saving..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="save">
|
||
Save
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Your saved search' panel"
|
||
ref="linksrc=close_saved_search_panel"
|
||
aria-controls="saved-search-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Create a file for external citation management software
|
||
</h2>
|
||
<form id="citation-manager-action-panel-form"
|
||
class="action-panel-content action-form"
|
||
action="/results-export-ids/"
|
||
data-by-search-action="/results-export-search-data/"
|
||
data-by-ids-action="/results-export-ids/"
|
||
method="post"
|
||
data-by-search-method="post"
|
||
data-by-ids-method="post">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="AubOTOXtpCX43K9ctul5fqxDDUYkY2WSRhVTwEqPZdKyXbf26NY7Jy3hbYGwRDuc">
|
||
|
||
|
||
|
||
<input name="results-format" type="hidden" value="pubmed"/>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Sending..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="citation_manager"
|
||
data-ga-label="save">
|
||
Create file
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Send citations to citation manager' panel"
|
||
ref="linksrc=close_citation_manager_panel"
|
||
aria-controls="citation-manager-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="citation_manager"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Your RSS Feed
|
||
</h2>
|
||
|
||
<form id="rss-action-panel-form"
|
||
class="rss-action-panel-form action-panel-content action-form"
|
||
data-create-rss-feed-url="/create-rss-feed-url/"
|
||
data-search-form-term-value="">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="AubOTOXtpCX43K9ctul5fqxDDUYkY2WSRhVTwEqPZdKyXbf26NY7Jy3hbYGwRDuc">
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="rss-name" class="action-panel-label required-field-asterisk">
|
||
Name of RSS Feed:
|
||
</label>
|
||
<input maxlength="200"
|
||
placeholder="Name"
|
||
type="text"
|
||
name="rss-name"
|
||
id="rss-name"
|
||
class="rss-name"
|
||
value=''
|
||
required
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/">
|
||
</div>
|
||
|
||
<div class="rss-limit-wrap">
|
||
<div class="action-panel-control-wrap action-panel-extra-margin-top">
|
||
<label for="rss-limit" class="action-panel-label">
|
||
Number of items displayed:
|
||
</label>
|
||
<select id="rss-limit" class="no-border-panel-selector rss-limit">
|
||
<option value="5">5</option>
|
||
<option value="10">10</option>
|
||
<option value="15" selected="selected">15</option>
|
||
<option value="20">20</option>
|
||
<option value="50">50</option>
|
||
<option value="100">100</option>
|
||
</select>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Creating..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="save">
|
||
Create RSS
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Your RSS' panel"
|
||
ref="linksrc=close_rss_panel"
|
||
aria-controls="rss-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap rss-link-copy-wrap">
|
||
<label for="rss-link" class="usa-sr-only">RSS Link</label>
|
||
<input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link">
|
||
<button
|
||
type="button"
|
||
disabled
|
||
class="rss-link-copy-button disabled"
|
||
data-ga-category="save_share"
|
||
data-ga-action="rss"
|
||
data-ga-label="copy">
|
||
Copy
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="article-page" id="article-page" data-article-pmid="17640524">
|
||
<aside class="page-sidebar">
|
||
<div class="inner-wrap">
|
||
|
||
<div class="full-text-links">
|
||
<div class="full-view">
|
||
<h3 class="title">
|
||
Full text links
|
||
</h3>
|
||
<div class="full-text-links-list">
|
||
<a class="link-item
|
||
|
||
dialog-focus"
|
||
href="https://linkinghub.elsevier.com/retrieve/pii/S0896-6273(07)00463-1"
|
||
target="_blank"
|
||
rel="noopener"
|
||
|
||
ref="linksrc=fulltextorjournal_fulltext&is_pmc=False&PrId=3048&itool=Abstract-def&log$=linkouticon&uid=17640524&db=pubmed&nlmid=8809320"
|
||
title="See full text options at Elsevier Science"
|
||
|
||
data-ga-category="full_text"
|
||
data-ga-action="Elsevier Science"
|
||
data-ga-label="17640524"
|
||
><img src="https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--linkinghub.elsevier.com-ihub-images-celloa.png" alt="Elsevier Science full text link"><span class="text">
|
||
|
||
Elsevier Science
|
||
|
||
</span></a><a class="link-item
|
||
pmc
|
||
"
|
||
href="https://pmc.ncbi.nlm.nih.gov/articles/pmid/17640524/"
|
||
target="_blank"
|
||
rel="noopener"
|
||
|
||
ref="linksrc=fulltextorjournal_fulltext&is_pmc=True&PrId=3494&itool=Abstract-def&log$=linkouticon&uid=17640524&db=pubmed&nlmid=8809320"
|
||
title="Free full text at PubMed Central"
|
||
|
||
data-ga-category="full_text"
|
||
data-ga-action="PMC"
|
||
data-ga-label="17640524"
|
||
><span class="text">
|
||
|
||
Free PMC article
|
||
|
||
</span></a>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="short-view">
|
||
<a href="#" class="full-text-links-button full-text-links-dialog-trigger">
|
||
Full text links
|
||
</a>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div class="actions-buttons sidebar"><h3 class="title">Actions</h3><div class="inner-wrap"><button class="citation-button citation-dialog-trigger"
|
||
aria-label="Open dialog with citation text in different styles"
|
||
data-ga-category="save_share"
|
||
data-ga-action="cite"
|
||
data-ga-label="open"
|
||
data-all-citations-url="/17640524/citations/"
|
||
data-citation-style="nlm"
|
||
data-pubmed-format-link="/17640524/export/"><span class="button-label">Cite</span></button><link type="text/css" href="ncbi-overlay-block/src/overlay-block.css"><div class="collections-button-container" data-article-id="17640524" data-article-db="pubmed"><button class="collections-button collections-dialog-trigger"
|
||
aria-label="Save article in MyNCBI collections."
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="collections_button"
|
||
data-collections-open-dialog-enabled="false"
|
||
data-collections-open-dialog-url="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F17640524%2F%23open-collections-dialog"
|
||
data-in-collections="false"><span class="button-label">Collections</span></button><div class="overlay" role="dialog"><div id="collections-action-dialog"
|
||
class="dialog collections-dialog"
|
||
aria-hidden="true"><div class="title">Add to Collections</div><div class="collections-action-panel action-panel"><form id="collections-action-dialog-form"
|
||
class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
|
||
data-existing-collections-url="/list-existing-collections/"
|
||
data-add-to-existing-collection-url="/add-to-existing-collection/"
|
||
data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/"
|
||
data-myncbi-max-collection-name-length="100"
|
||
data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"><input type="hidden" name="csrfmiddlewaretoken" value="AubOTOXtpCX43K9ctul5fqxDDUYkY2WSRhVTwEqPZdKyXbf26NY7Jy3hbYGwRDuc"><div class="choice-group" role="radiogroup"><ul class="radio-group-items"><li><input type="radio"
|
||
id="collections-action-dialog-new"
|
||
class="collections-new"
|
||
name="collections"
|
||
value="new"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="collections_radio_new"><label for="collections-action-dialog-new">Create a new collection</label></li><li><input type="radio"
|
||
id="collections-action-dialog-existing"
|
||
class="collections-existing"
|
||
name="collections"
|
||
value="existing"
|
||
checked="true"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li></ul></div><div class="controls-wrapper"><div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk">
|
||
Name your collection:
|
||
</label><input
|
||
type="text"
|
||
name="add-to-new-collection"
|
||
id="collections-action-dialog-add-to-new"
|
||
class="collections-action-add-to-new"
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"
|
||
maxlength="100"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="create_collection"
|
||
data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message">
|
||
Name must be less than 100 characters
|
||
</div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label">
|
||
Choose a collection:
|
||
</label><select id="collections-action-dialog-add-to-existing"
|
||
class="action-panel-selector collections-action-add-to-existing"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="select_collection"
|
||
data-ga-label="($('.collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"></select><div class="collections-retry-load-on-error usa-input-error-message selection-validation-message">
|
||
Unable to load your collection due to an error<br><a href="#">Please try again</a></div></div></div><div class="action-panel-actions"><button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Adding..."
|
||
data-pinger-ignore
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="add">
|
||
Add
|
||
</button><button class="action-panel-cancel"
|
||
aria-label="Close 'Add to Collections' panel"
|
||
ref="linksrc=close_collections_panel"
|
||
aria-controls="collections-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button></div></form></div></div></div></div><button class="more-actions-button more-actions-dialog-trigger"
|
||
title="Open dialog with more actions to take"
|
||
ref="linksrc=more_actions_btn"></button><div class="display-options" data-format-key="format"
|
||
data-default-format-value="abstract"
|
||
data-current-format-value="abstract" role="region"><button
|
||
class="trigger usa-button"
|
||
title="Change format"
|
||
data-ga-category="display_options"
|
||
data-ga-action="display_options_dialog"><span class="button-label">Display options</span></button><div class="dropdown" hidden><div class="title">
|
||
Display options
|
||
</div><div class="content"><div class="format-container"><span class="option-label">
|
||
Format
|
||
</span><select name="format" data-initial-value="abstract" aria-label="Display format" id="sidebar-actions-display-format"><option value="abstract">Abstract</option><option value="pubmed">PubMed</option><option value="pmid">PMID</option></select></div></div></div></div></div></div>
|
||
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</a></li></ul></div></div></div><span class="period">. </span><span class="cit">2007 Jul 19;55(2):217-30.</span>
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<h1 class="heading-title">
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The transcription factor Yin Yang 1 is essential for oligodendrocyte progenitor differentiation
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</h1>
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The transcription factor Yin Yang 1 is essential for oligodendrocyte progenitor differentiation
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The progression of progenitors to oligodendrocytes requires proliferative arrest and the activation of a transcriptional program of differentiation. While regulation of cell cycle exit has been extensively characterized, the molecular mechanisms responsible for the initiation of differentiation remain ill-defined. Here, we identify the transcription factor Yin Yang 1 (YY1) as a critical regulator of oligodendrocyte progenitor differentiation. Conditional ablation of yy1 in the oligodendrocyte lineage in vivo induces a phenotype characterized by defective myelination, ataxia, and tremor. At the cellular level, lack of yy1 arrests differentiation of oligodendrocyte progenitors after they exit from the cell cycle. At the molecular level, YY1 acts as a lineage-specific repressor of transcriptional inhibitors of myelin gene expression (Tcf4 and Id4), by recruiting histone deacetylase-1 to their promoters during oligodendrocyte differentiation. Thus, we identify YY1 as an essential component of the transcriptional network regulating the transition of oligodendrocyte progenitors from cell cycle exit to differentiation.
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Figure 1. Conditional ablation of YY1 in the oligodendrocyte lineage in mice results in a trembling phenotype
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<div class="figure-caption-contents">(A) Conditional <i>yy1</i> knockout mice (cko), obtained by crossing <i>yy1<sup>flox/flox</sup></i> with <i>Cnp-cre</i> mice displayed progressive tremor, ataxia and head wobbling during the second-third postnatal week. Examples of abnormal posturing and gait in the mutant mice (cko) at postnatal day 18 (p18) are shown in comparison with control siblings (ctrl). (B) Double immunostaining of cells in white matter tracts of p18 mouse sections stained for YY1 (red) and cell-specific markers (green): CC1 for oligodendrocytes, GFAP for astrocytes and NeuN for neurons. Note the specific deletion of YY1 in oligodendrocytes. Scale bar = 20 μm. (C) Quantitative real-time PCR of brain RNA from wild type (<i>yy1</i><sup>+/+</sup>; <i>cnp-cre</i><sup>+/-</sup>), heterozygotes (<i>yy1</i><sup><i>flox/+</i></sup>; <i>cnp-cre</i><sup>+/-</sup>) and conditional knockout (<i>yy1</i><sup><i>flox/flox</i></sup>; <i>cnpcre</i><sup>+/-</sup>) mice at p14. The levels of the indicated transcripts are normalized to GAPDH and the mRNA control levels are arbitrarily set as 100. The bar graph indicates decreased myelin gene transcripts in <i>yy1</i> cko mice (black), but not in heterozygous siblings (gray) compared to controls (white) *p<0.05, **p<0.01. (D) Western blot analysis of protein lysates from the cortex of p14 mice revealed decreased myelin basic protein (MBP) expression in the mutants. Beta-actin serves as loading control. (E) Brain sagittal sections stained for PLP (3wks) and for MBP (8wks) reveal fewer myelinated fibers in the corpus callosum (cc), fornix (f) and cerebellum of <i>yy1</i> cko mice compared to controls (ctrl). Scale bar = 100 μm.</div>
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href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2642/2034312/0313665f23d2/nihms-27589-f0002.jpg"
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data-figure-id="F2">
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src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2642/2034312/0815107cf3a1/nihms-27589-f0002.gif"
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alt="Figure 2" />
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<strong class="figure-label">
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<p> Figure 2. Defective myelination in the spinal… </p>
|
||
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<strong class="figure-label">
|
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<p> Figure 2. Defective myelination in the spinal cord of <i> yy1 </i> conditional knockout mice </p>
|
||
</strong>
|
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|
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|
||
<div class="figure-caption-contents"><p> (A) Ultrastructural… </p></div>
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<strong class="figure-label">
|
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Figure 2. Defective myelination in the spinal cord of <i>yy1</i> conditional knockout mice
|
||
</strong>
|
||
|
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|
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|
||
<div class="figure-caption-contents">(A) Ultrastructural analysis of spinal cord sections shows lack of myelin (asterisks) and thinner myelin sheaths (arrows) in p18 <i>yy1</i> cko mice compared to controls. Scale bar= 2 μm. (B) Bar graph shows increased % of unmyelinated axons relative to total number of axons in the spinal cord of <i>yy1</i> cko mice (black) compared to controls (gray). (C) Bar graph shows the relative distribution of unmyelinated and myelinated axons in relation to axonal diameter in the spinal cord of <i>yy1</i> cko mice (black) and controls (gray) at p18 *p<0.05; **p<0.01. (D) Representative EM picture of a large <i>yy1</i> cko spinal cord axon (diameter >1.5μm) that lacks myelin (*) and is in contact with an astrocytic process (+). Scale bar = 200 nm. (E) Representative EM pictures of myelinated axons of equivalent diameter in control and <i>yy1</i> cko siblings. Scale bar = 100nm.</div>
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href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2642/2034312/a14805a9448f/nihms-27589-f0003.jpg"
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data-image-alt="Figure 3"
|
||
data-pmc-id="PMC2034312"
|
||
data-figure-id="F3">
|
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<img class="figure-thumb" itemprop="thumbnail"
|
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id="article-image-2"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2642/2034312/9eda17fc592c/nihms-27589-f0003.gif"
|
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alt="Figure 3" />
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|
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<strong class="figure-label">
|
||
<p> Figure 3. Impaired oligodendrocyte progenitor differentiation in… </p>
|
||
</strong>
|
||
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|
||
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||
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||
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||
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||
|
||
<strong class="figure-label">
|
||
<p> Figure 3. Impaired oligodendrocyte progenitor differentiation in the spinal cord of <i> yy1 </i> conditional mutants </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> (A)… </p></div>
|
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<figcaption id="figure-caption-2" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
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|
||
<strong class="figure-label">
|
||
Figure 3. Impaired oligodendrocyte progenitor differentiation in the spinal cord of <i>yy1</i> conditional mutants
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">(A) Confocal image of lumbar spinal cord sections from controls (ctrl) and <i>yy1</i> cko mice at postnatal day 2, 11 and 18, stained with antibodies specific for NG2 (green) to identify progenitors, CC1 (red) to identify oligodendrocytes and DAPI (blue) to counterstain nuclei. Optical sections (<i>Z</i> = 1.0 μm; <i>X</i> = 12 μm) of confocal epifluorescence images were sequentially acquired and LSM software was used to merge images. Examples of NG2<sup>+</sup>/DAPI<sup>+</sup> and CC1<sup>+</sup>/DAPI<sup>+</sup>cells selected for counting are shown in the boxed areas (arrowheads) while their relative position is shown at low magnification (arrows). Scale bar=50μm, 10μm in inserts. (B) Quantification of the data shown in panel A. The values indicate mean ± SD of cell counts obtained in 3-4 mice of each genotype per time point. (C) Co-localization of progenitor markers PDGFRα (red) and NG2 (green) in the spinal cord of <i>yy1</i> cko mice at p18. Scale bar=20μm</div>
|
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|
||
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|
||
data-figure-id="F4">
|
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<img class="figure-thumb" itemprop="thumbnail"
|
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id="article-image-3"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2642/2034312/ede0314a555d/nihms-27589-f0004.gif"
|
||
alt="Figure 4" />
|
||
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|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 4. In vitro ablation of <i> yy1… </i> </p>
|
||
</strong>
|
||
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||
|
||
|
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||
|
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|
||
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|
||
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|
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|
||
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||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 4. In vitro ablation of <i> yy1 </i> in oligodendrocyte progenitors prevents their differentiation into oligodendrocytes </p>
|
||
</strong>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-3" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 4. In vitro ablation of <i>yy1</i> in oligodendrocyte progenitors prevents their differentiation into oligodendrocytes
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">(A) Primary oligodendrocyte progenitors isolated from the cortex of neonatal <i>yy1</i><sup><i>flox/flox</i></sup> mice were transduced with adenoviral vectors expressing the recombinase Cre (CMV-<i>Cre</i>). Forty-eight hours later the cells were differentiated by mitogen withdrawal. Immunoreactivity for O4 (green) was assessed 3 days later, while immunoreactivity for MBP, GalC or PLP (green) was assessed 5 days after transduction. Note that the Cre<sup>+</sup> <i>yy1</i><sup><i>flox/flox</i></sup> cells (red) progressed to the O4<sup>+</sup> stage, but were unable to differentiate into myelin-expressing cells. Scale bar = 50μm. (B) Quantification of three distinct experiments performed in duplicate. * p<0.05, ***p<0.001.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
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|
||
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|
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|
||
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|
||
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|
||
data-image-alt="Figure 5"
|
||
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|
||
data-figure-id="F5">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
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id="article-image-4"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2642/2034312/0dda6735d64e/nihms-27589-f0005.gif"
|
||
alt="Figure 5" />
|
||
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|
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|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 5. Lack of YY1 does not… </p>
|
||
</strong>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
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|
||
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|
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|
||
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|
||
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||
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||
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||
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||
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||
|
||
<strong class="figure-label">
|
||
<p> Figure 5. Lack of YY1 does not affect the ability of oligodendrocyte progenitors to exit… </p>
|
||
</strong>
|
||
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|
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<figcaption id="figure-caption-4" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
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||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 5. Lack of YY1 does not affect the ability of oligodendrocyte progenitors to exit from the cell cycle
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">(A) Confocal image of spinal cord sections of p2 <i>yy1</i> cko and control siblings (ctrl) <i>in vivo</i> labeled with BrdU for 1 hour. Immunohistochemistry with YY1 (red), BrdU (green) and DAPI (blue) revealed a similar distribution BrdU<sup>+</sup> cells in mice of the two genotypes. Scale bar = 20μm. (B) Quantification of BrdU<sup>+</sup> cells in white matter tracts of the spinal cord at the indicated time points; *p<0.05. (C) Representative images of spinal cord sections of control and cko mice stained with antibodies against Ki-67 (green) to identify cells in any phase of the cell cycle except for G0 and BrdU (red) to identify cells in S phase at the time of labeling. (D) Cell cycle exit index was calculated by dividing the number of BrdU<sup>+</sup>/Ki-67<sup>−</sup> cells, by the total number of BrdU<sup>+</sup> cells. Scale bar = 20μm.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
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|
||
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|
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|
||
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|
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|
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|
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|
||
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|
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|
||
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|
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|
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src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2642/2034312/e3654ec2c91f/nihms-27589-f0006.gif"
|
||
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|
||
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|
||
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||
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||
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|
||
<strong class="figure-label">
|
||
<p> Figure 6. YY1 is a repressor of… </p>
|
||
</strong>
|
||
|
||
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||
|
||
|
||
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|
||
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|
||
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|
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<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
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|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 6. YY1 is a repressor of oligodendrocyte differentiation inhibitors Id4 and Tcf4 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> (A) Validation… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-5" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
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||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 6. YY1 is a repressor of oligodendrocyte differentiation inhibitors Id4 and Tcf4
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">(A) Validation of gene expression profiling studies in the cortex of <i>yy1</i> cko mice and control littermates at p2, by semi-quantitative (A) and quantitative (B) RT-PCR. The RNA levels were normalized to the levels of GAPDH and the values in the control mice were arbitrarily set as 1. *p<0.05. (C) The expression level of <i>Tcf4</i> and <i>Id4</i> was down-regulated in oligodendrocyte progenitors transfected with pCX-<i>yy1</i>-EGFP (YY1) and not in cells transfected with pCX-EGFP vector as control. (D) Luciferase activity of immortalized oligodendrocyte progenitors (Oli-neu cells) co-transfected with <i>Tcf4</i>, and either myelin (MBP-luc, CGT-luc) or astrocytes-specific (GFAP-luc) promoters driving luciferase reporters. The luciferase activity in pCDNA3 transfected controls was arbitrarily set as 100; ** p<0.01.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
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|
||
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|
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|
||
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|
||
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|
||
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|
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|
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|
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|
||
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|
||
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|
||
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|
||
<img class="figure-thumb" itemprop="thumbnail"
|
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|
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src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2642/2034312/16bd3a6e18ea/nihms-27589-f0007.gif"
|
||
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|
||
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|
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|
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|
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<strong class="figure-label">
|
||
<p> Figure 7. In vitro ablation of YY1… </p>
|
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<p> Figure 7. In vitro ablation of YY1 in nestin <sup> + </sup> precursor cells impairs oligodendrocyte differentiation… </p>
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<strong class="figure-label">
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Figure 7. In vitro ablation of YY1 in nestin<sup>+</sup> precursor cells impairs oligodendrocyte differentiation in a cell type specific manner
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</strong>
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<div class="figure-caption-contents">(A) Subventricular zone (SVZ) cells were isolated from neonatal <i>yy1</i><sup><i>flox/flox</i></sup> mice and cultured as nestin<sup>+</sup> (green) neurospheres. Dissociated neurospheres without (ctrl) or with adenovirus-CMV-Cre transduction (cre) were allowed to differentiate into oligodendrocytes, astrocytes and neurons. Seven days later the cultures were stained for Cre (red) and for the lineage specific markers (green): Gal C (oligodendrocytes), GFAP (astrocytes) and Tuj1 (neurons). Scale bar=50μm. (B) Bar graphs indicate the percentage of immunoreactive cells relative to total cell number. * p<0.05. (C) The experiment was repeated in medium supplemented with retinoic acid (RA) to promote neuronal differentiation. (D) Bar graphs show that even in this culture condition no significant difference was detected between control and <i>yy1</i>- cells.</div>
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<p> Figure 8. The YY1-dependent repression of Tcf4… </p>
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<p> Figure 8. The YY1-dependent repression of Tcf4 and Id4 is lineage-specific and mediated by recruitment… </p>
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<strong class="figure-label">
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Figure 8. The YY1-dependent repression of Tcf4 and Id4 is lineage-specific and mediated by recruitment of HDAC1 to their promoters
|
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</strong>
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<div class="figure-caption-contents">(A) Quantitative RT-PCR of <i>Tcf4</i>, <i>Id4</i> and <i>REST</i> in oligodendrocyte progenitors transfected with pCX-EGFP (vector) or pCX-<i>yy1</i>-EGFP (YY1) and induced to differentiate into astrocytes (astro) or oligodendrocytes (oligo). The transcript levels of each gene in vector transfected cells was arbitrarily set as 100; *p<0.05. (B) Co-immunoprecipitation of YY1 and HDAC-1 and -2. Western blot analysis of whole cell lysates (lysates) and YY1 immunoprecipitated protein extracts (IP:YY1) derived from undifferentiated progenitors (prog) and cells differentiated into oligodendrocytes (diff prog) or astrocytes (astro). (C) YY1 activity, measured by TransLucent vector reporter system. Note the increased activity of YY1 in cultures of progenitors differentiating into oligodendrocytes (diff. prog.) compared to undifferentiated cells (prog.) or cells differentiating into astrocytes (astro). **p<0.01. (D) Chromatin immunoprecipitation (ChIP) of samples isolated from progenitors (prog), differentiating oligodendrocytes (diff) or astrocytes (astro) and immunoprecipitated with antibodies against YY1 and HDAC1. The diagram shows the <i>Tcf4</i> promoter with the relative position of the YY1 consensus sequences (black boxes) and the regions of DNA (roman numerals) amplified by specific primer pairs (arrows). Input DNA was used as positive control, while ChIP in the absence of antibodies or amplification of immunoprecipitated chromatin with primers for region IV were used as negative controls. (E) ChIP of samples isolated in the same conditions described above. The diagram shows the <i>Id4</i> promoter, with the position of the YY1 consensus sequence (black box) and the regions of the promoter (roman numerals) amplified by specific primer pairs (arrows). YY1 was bound to the <i>Id4</i> promoter in progenitors, but it recruited HDAC1 only when cells differentiated into oligodendrocytes. No binding was observed in progenitors differentiating into astrocytes. (F) Model of oligodendrocyte progenitor differentiation as two step event. First, proliferating progenitors exit from the cell cycle and remain in an undifferentiated state characterized by high levels of transcriptional inhibitors (Id4, Tcf4) and lack of myelin gene expression. As the progenitors begin differentiating, repressive complexes containing YY1 and HDAC1 are recruited to the promoter of these inhibitors. The decreased levels of these inhibitory molecules allow myelin gene expression to begin.</div>
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data-ga-action="mesh_term"
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data-ga-label="Animals">
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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ref="linksrc=search_in_mesh_link"
|
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Animals"
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data-ga-category="search_mesh"
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data-ga-action="mesh_term_link"
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data-ga-label="Animals">
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Search in MeSH
|
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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data-search-term=""Animals"[MeSH]"
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data-ga-category="search"
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data-ga-action="add_to_search"
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data-ga-label=""Animals"[MeSH]"
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href="#">
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword Cell Cycle / genetics"
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tabindex="0"
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aria-controls="keyword-actions-mesh-terms-1"
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Cell Cycle / genetics
|
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</button><div id="keyword-actions-mesh-terms-1"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
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hidden
|
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aria-label="Dropdown menu for keyword Cell Cycle / genetics"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
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href="/?term=%22Cell+Cycle%2Fgenetics%22%5BMeSH%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Cell+Cycle%2Fgenetics%22%5BMeSH%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Cell Cycle/genetics"[MeSH]"
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data-ga-action="mesh_term"
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data-ga-label="Cell Cycle / genetics">
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Cell+Cycle"
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Search in MeSH
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword Cell Cycle / physiology"
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tabindex="0"
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data-pinger-ignore>
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Cell Cycle / physiology
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</button><div id="keyword-actions-mesh-terms-2"
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class="keyword-actions-dropdown dropdown dropdown-container"
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hidden
|
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aria-label="Dropdown menu for keyword Cell Cycle / physiology"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
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href="/?term=%22Cell+Cycle%2Fphysiology%22%5BMeSH%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Cell+Cycle%2Fphysiology%22%5BMeSH%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Cell Cycle/physiology"[MeSH]"
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Cell+Cycle"
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Search in MeSH
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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data-ga-label=""Cell Cycle/physiology"[MeSH]"
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major"
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aria-label="Toggle dropdown menu for keyword Cell Differentiation / physiology*"
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tabindex="0"
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aria-controls="keyword-actions-mesh-terms-major-3"
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aria-expanded="false"
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data-pinger-ignore>
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Cell Differentiation / physiology*
|
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</button><div id="keyword-actions-mesh-terms-major-3"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
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aria-label="Dropdown menu for keyword Cell Differentiation / physiology*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
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href="/?term=%22Cell+Differentiation%2Fphysiology%22%5BMAJR%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Cell+Differentiation%2Fphysiology%22%5BMAJR%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Cell Differentiation/physiology"[MAJR]"
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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data-search-term=""Cell Differentiation/physiology"[MAJR]"
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data-ga-category="search"
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword Cell Lineage / physiology"
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tabindex="0"
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aria-controls="keyword-actions-mesh-terms-4"
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Cell Lineage / physiology
|
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</button><div id="keyword-actions-mesh-terms-4"
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class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
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aria-label="Dropdown menu for keyword Cell Lineage / physiology"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
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href="/?term=%22Cell+Lineage%2Fphysiology%22%5BMeSH%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Cell+Lineage%2Fphysiology%22%5BMeSH%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Cell Lineage/physiology"[MeSH]"
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Cell+Lineage"
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data-ga-category="search_mesh"
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Search in MeSH
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major"
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aria-label="Toggle dropdown menu for keyword Gene Expression Regulation, Developmental / physiology*"
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tabindex="0"
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aria-controls="keyword-actions-mesh-terms-major-5"
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aria-expanded="false"
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data-pinger-ignore>
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Gene Expression Regulation, Developmental / physiology*
|
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</button><div id="keyword-actions-mesh-terms-major-5"
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class="keyword-actions-dropdown dropdown dropdown-container"
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hidden
|
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aria-label="Dropdown menu for keyword Gene Expression Regulation, Developmental / physiology*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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|
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data-href="/?term=%22Gene+Expression+Regulation%2C+Developmental%2Fphysiology%22%5BMAJR%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Gene Expression Regulation, Developmental/physiology"[MAJR]"
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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Search in MeSH
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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data-search-term=""Gene Expression Regulation, Developmental/physiology"[MAJR]"
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data-ga-category="search"
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
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aria-label="Toggle dropdown menu for keyword Mice"
|
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tabindex="0"
|
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aria-controls="keyword-actions-mesh-terms-6"
|
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aria-expanded="false"
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data-pinger-ignore>
|
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Mice
|
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</button><div id="keyword-actions-mesh-terms-6"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
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aria-label="Dropdown menu for keyword Mice"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
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href="/?term=%22Mice%22%5BMeSH%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Mice%22%5BMeSH%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Mice"[MeSH]"
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Mice"
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role="button"
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data-search-term=""Mice"[MeSH]"
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data-ga-category="search"
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data-ga-action="add_to_search"
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data-ga-label=""Mice"[MeSH]"
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href="#">
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword Mice, Knockout"
|
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tabindex="0"
|
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aria-controls="keyword-actions-mesh-terms-7"
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aria-expanded="false"
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data-pinger-ignore>
|
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Mice, Knockout
|
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</button><div id="keyword-actions-mesh-terms-7"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
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aria-label="Dropdown menu for keyword Mice, Knockout"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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href="/?term=%22Mice%2C+Knockout%22%5BMeSH%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Mice%2C+Knockout%22%5BMeSH%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Mice, Knockout"[MeSH]"
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data-ga-label="Mice, Knockout">
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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Search in MeSH
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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data-ga-category="search"
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data-ga-action="add_to_search"
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href="#">
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword Mice, Mutant Strains"
|
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tabindex="0"
|
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aria-controls="keyword-actions-mesh-terms-8"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Mice, Mutant Strains
|
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</button><div id="keyword-actions-mesh-terms-8"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
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aria-label="Dropdown menu for keyword Mice, Mutant Strains"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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href="/?term=%22Mice%2C+Mutant+Strains%22%5BMeSH%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Mice%2C+Mutant+Strains%22%5BMeSH%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Mice, Mutant Strains"[MeSH]"
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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Search in MeSH
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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data-search-term=""Mice, Mutant Strains"[MeSH]"
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data-ga-category="search"
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
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aria-label="Toggle dropdown menu for keyword Myelin Sheath / metabolism"
|
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tabindex="0"
|
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aria-controls="keyword-actions-mesh-terms-9"
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aria-expanded="false"
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data-pinger-ignore>
|
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Myelin Sheath / metabolism
|
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</button><div id="keyword-actions-mesh-terms-9"
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class="keyword-actions-dropdown dropdown dropdown-container"
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hidden
|
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aria-label="Dropdown menu for keyword Myelin Sheath / metabolism"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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href="/?term=%22Myelin+Sheath%2Fmetabolism%22%5BMeSH%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Myelin+Sheath%2Fmetabolism%22%5BMeSH%5D&sort=date&sort_order=desc"
|
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Myelin Sheath/metabolism"[MeSH]"
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data-ga-label="Myelin Sheath / metabolism">
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Myelin+Sheath"
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Search in MeSH
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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data-search-term=""Myelin Sheath/metabolism"[MeSH]"
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data-ga-category="search"
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data-ga-action="add_to_search"
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data-ga-label=""Myelin Sheath/metabolism"[MeSH]"
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword Nerve Fibers, Myelinated / metabolism"
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tabindex="0"
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aria-controls="keyword-actions-mesh-terms-10"
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aria-expanded="false"
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data-pinger-ignore>
|
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Nerve Fibers, Myelinated / metabolism
|
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</button><div id="keyword-actions-mesh-terms-10"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
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hidden
|
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aria-label="Dropdown menu for keyword Nerve Fibers, Myelinated / metabolism"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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href="/?term=%22Nerve+Fibers%2C+Myelinated%2Fmetabolism%22%5BMeSH%5D&sort=date&sort_order=desc"
|
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data-href="/?term=%22Nerve+Fibers%2C+Myelinated%2Fmetabolism%22%5BMeSH%5D&sort=date&sort_order=desc"
|
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Nerve Fibers, Myelinated/metabolism"[MeSH]"
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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Search in MeSH
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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ref="linksrc=add_to_search_link"
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role="button"
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data-search-term=""Nerve Fibers, Myelinated/metabolism"[MeSH]"
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data-ga-category="search"
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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|
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Oligodendroglia / cytology
|
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aria-label="Dropdown menu for keyword Oligodendroglia / cytology"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
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href="/?term=%22Oligodendroglia%2Fcytology%22%5BMeSH%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Oligodendroglia%2Fcytology%22%5BMeSH%5D&sort=date&sort_order=desc"
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Oligodendroglia / metabolism*
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aria-label="Dropdown menu for keyword Oligodendroglia / metabolism*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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href="/?term=%22Oligodendroglia%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Oligodendroglia%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc"
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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Stem Cells / cytology
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Add to Search
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Stem Cells / metabolism*
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</button><div id="keyword-actions-mesh-terms-major-14"
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class="keyword-actions-dropdown dropdown dropdown-container"
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hidden
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aria-label="Dropdown menu for keyword Stem Cells / metabolism*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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href="/?term=%22Stem+Cells%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Stem+Cells%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Stem Cells/metabolism"[MAJR]"
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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Add to Search
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword Transcription, Genetic / physiology"
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data-pinger-ignore>
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Transcription, Genetic / physiology
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</button><div id="keyword-actions-mesh-terms-15"
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hidden
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aria-label="Dropdown menu for keyword Transcription, Genetic / physiology"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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data-href="/?term=%22Transcription%2C+Genetic%2Fphysiology%22%5BMeSH%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Transcription, Genetic/physiology"[MeSH]"
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Search in MeSH
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Add to Search
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major"
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aria-label="Toggle dropdown menu for keyword YY1 Transcription Factor / metabolism*"
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tabindex="0"
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aria-expanded="false"
|
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data-pinger-ignore>
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YY1 Transcription Factor / metabolism*
|
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</button><div id="keyword-actions-mesh-terms-major-16"
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class="keyword-actions-dropdown dropdown dropdown-container"
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hidden
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aria-label="Dropdown menu for keyword YY1 Transcription Factor / metabolism*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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href="/?term=%22YY1+Transcription+Factor%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc"
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data-href="/?term=%22YY1+Transcription+Factor%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&mesh="YY1 Transcription Factor/metabolism"[MAJR]"
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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Search in MeSH
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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role="button"
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data-search-term=""YY1 Transcription Factor/metabolism"[MAJR]"
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Add to Search
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</a></li></ul></div></div></div></li></ul>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
<div id="substances" class="substances keywords-section">
|
||
<h2 class="title">
|
||
Substances
|
||
</h2>
|
||
|
||
<ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword YY1 Transcription Factor"
|
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tabindex="0"
|
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aria-controls="keyword-actions-substances-0"
|
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aria-expanded="false"
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data-pinger-ignore>
|
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YY1 Transcription Factor
|
||
</button><div id="keyword-actions-substances-0"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
||
aria-label="Dropdown menu for keyword YY1 Transcription Factor"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22YY1+Transcription+Factor%22%5Bnm%5D&sort=date&sort_order=desc"
|
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data-href="/?term=%22YY1+Transcription+Factor%22%5Bnm%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&keyword="YY1 Transcription Factor"[nm]"
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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href="https://www.ncbi.nlm.nih.gov/mesh?term=%22YY1+Transcription+Factor%22"
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data-ga-action="substance_link"
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Search in MeSH
|
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</a></li><li><a class="add-to-search-link dropdown-block-link"
|
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ref="linksrc=add_to_search_link"
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role="button"
|
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data-search-term=""YY1 Transcription Factor"[nm]"
|
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data-ga-category="search"
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data-ga-action="add_to_search"
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href="#">
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword Yy1 protein, mouse"
|
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tabindex="0"
|
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aria-controls="keyword-actions-substances-1"
|
||
aria-expanded="false"
|
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data-pinger-ignore>
|
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Yy1 protein, mouse
|
||
</button><div id="keyword-actions-substances-1"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
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hidden
|
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aria-label="Dropdown menu for keyword Yy1 protein, mouse"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
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href="/?term=%22Yy1+protein%2C+mouse%22%5Bnm%5D&sort=date&sort_order=desc"
|
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data-href="/?term=%22Yy1+protein%2C+mouse%22%5Bnm%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&keyword="Yy1 protein, mouse"[nm]"
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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Search in MeSH
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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data-search-term=""Yy1 protein, mouse"[nm]"
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Add to Search
|
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</a></li></ul></div></div></div></li></ul>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div id="related-links" class="related-links">
|
||
<h2 class="title">
|
||
Related information
|
||
</h2>
|
||
|
||
<ul class="related-links-list"><li><a title="PubMed links associated with Books" href="https://www.ncbi.nlm.nih.gov/books?linkname=pubmed_books_refs&from_uid=17640524"
|
||
ref="log$=recordlinks&logdbfrom=pubmed&ncbi_uid=17640524&ordinalpos=1&linkpos=1">
|
||
Cited in Books
|
||
</a></li><li><a title="Link to related Genes" href="https://www.ncbi.nlm.nih.gov/gene?linkname=pubmed_gene&from_uid=17640524"
|
||
ref="log$=recordlinks&logdbfrom=pubmed&ncbi_uid=17640524&ordinalpos=1&linkpos=2">
|
||
Gene
|
||
</a></li><li><a title="Link to Gene for the GeneRIF subcategory" href="https://www.ncbi.nlm.nih.gov/gene?linkname=pubmed_gene_rif&from_uid=17640524"
|
||
ref="log$=recordlinks&logdbfrom=pubmed&ncbi_uid=17640524&ordinalpos=1&linkpos=3">
|
||
Gene (GeneRIF)
|
||
</a></li><li><a title="Related information in MedGen" href="https://www.ncbi.nlm.nih.gov/medgen?linkname=pubmed_medgen&from_uid=17640524"
|
||
ref="log$=recordlinks&logdbfrom=pubmed&ncbi_uid=17640524&ordinalpos=1&linkpos=4">
|
||
MedGen
|
||
</a></li><li><a title="Related records in MedGen based on citations in GeneReviews and Medical Genetics Summaries" href="https://www.ncbi.nlm.nih.gov/medgen?linkname=pubmed_medgen_bookshelf_cited&from_uid=17640524"
|
||
ref="log$=recordlinks&logdbfrom=pubmed&ncbi_uid=17640524&ordinalpos=1&linkpos=5">
|
||
MedGen (Bookshelf cited)
|
||
</a></li><li><a title="Link to Protein RefSeqs" href="https://www.ncbi.nlm.nih.gov/protein?linkname=pubmed_protein_refseq&from_uid=17640524"
|
||
ref="log$=recordlinks&logdbfrom=pubmed&ncbi_uid=17640524&ordinalpos=1&linkpos=6">
|
||
Protein (RefSeq)
|
||
</a></li></ul>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
<div id="grants" class="grants">
|
||
<h2 class="title">
|
||
Grants and funding
|
||
</h2>
|
||
<div class="grants-list"><ul id="grants-head-list"><li class="grant-item"><a
|
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title="All articles for grant GM53874/GM/NIGMS NIH HHS/United States"
|
||
href="/?term=GM53874%2FGM%2FNIGMS+NIH+HHS%2FUnited+States%5BGrants+and+Funding%5D&sort=date&sort_order=desc"
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GM53874/GM/NIGMS NIH HHS/United States
|
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</a></li><li class="grant-item"><a
|
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title="All articles for grant NS42925/NS/NINDS NIH HHS/United States"
|
||
href="/?term=NS42925%2FNS%2FNINDS+NIH+HHS%2FUnited+States%5BGrants+and+Funding%5D&sort=date&sort_order=desc"
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NS42925/NS/NINDS NIH HHS/United States
|
||
</a></li><li class="grant-item"><a
|
||
title="All articles for grant R01 NS042925/NS/NINDS NIH HHS/United States"
|
||
href="/?term=R01+NS042925%2FNS%2FNINDS+NIH+HHS%2FUnited+States%5BGrants+and+Funding%5D&sort=date&sort_order=desc"
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