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<meta name="description" content="NIDA is advancing the science on emergency medications like naloxone, which can save a life during an opioid overdose. Overdose reversal medications are safe and effective life-saving tools that can be given to someone experiencing a drug overdose. As a harm reduction tool, overdose reversal medications play a critical role in a science-based approach to the drug overdose crisis." />
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<ul><li>Overdose reversal medications are safe and effective life-saving tools that can be given to someone experiencing a drug overdose. Current overdose reversal medications— including <a href="/publications/drugfacts/naloxone" data-entity-type="node" data-entity-uuid="085728f1-1024-4c4c-9efd-f939ac5065ae" data-entity-substitution="canonical">naloxone</a> (Narcan<sup>®</sup>, Kloxxado<sup>®</sup>, Zimhi<sup>®</sup>, ReVive<sup>®</sup>) and nalmefene (Opvee<sup>®</sup>)—are approved to reverse overdoses caused by <a href="/node/20240" data-entity-type="node" data-entity-uuid="0815f5ea-b1c3-4862-97e1-0fcbccb9a7d9" data-entity-substitution="canonical">opioids</a> like <a href="/research-topics/fentanyl" data-entity-type="node" data-entity-uuid="b754d032-76e9-4a4e-947f-7f5adfd15a9e" data-entity-substitution="canonical">fentanyl</a>, though NIDA supports the development of new medications to reverse overdoses caused by other drugs. Nasal spray versions of naloxone and nalmefene are available and can be carried and administered by anyone. Two formulations of naloxone nasal spray are available without a prescription.</li><li>As a <a href="/research-topics/harm-reduction" data-entity-type="node" data-entity-uuid="d8ed3bbd-a102-4d4b-b5a4-815d8b569475" data-entity-substitution="canonical">harm reduction</a> tool, overdose reversal medications play a critical role in a science-based approach to the drug <a href="/node/18622" data-entity-type="node" data-entity-uuid="6437f58a-c8c5-42a5-896f-8317c7207062" data-entity-substitution="canonical">overdose crisis</a>. Overdose education and naloxone distribution programs have been shown in studies to be effective in preventing overdose deaths.<a href="#references"><sup>1, 2, 3</sup></a> By saving lives, overdose reversal medications can give people who use drugs more opportunities to access services they may need, such as treatment and recovery support for people with substance use disorders.</li><li>Certain naloxone and nalmefene formulations were developed with the <a href="/node/21261" data-entity-type="node" data-entity-uuid="e6fa1bf3-ffda-4a81-9eb7-a21900c8e420" data-entity-substitution="canonical">support of NIDA</a>. NIDA continues to support development of new and improved overdose reversal medications. These include tools that last longer, are more user-friendly, and reverse overdoses caused by drugs other than opioids and by combinations of multiple drugs. NIDA also funds research into more effective ways to detect and respond to overdose, distribute overdose reversal medications to the people who need them, and to prevent overdoses through education and harm reduction. </li></ul></div>
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<aside class="rt-flex--promo" role="complementary" style="border-left:3px solid #20558A; padding-left:1.2rem;">
|
||
|
||
<div><h3>Saving Lives with Peer Support</h3><p>Learn how peer support specialists like Chetwyn “Arrow” Archer help others connect with naloxone to prevent overdose deaths. </p><div class="align-center image-medium">
|
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<div> <img loading="lazy" src="/sites/default/files/styles/content_image_medium/public/images/arrow-archer-video.jpg?itok=a75MmpOp" width="426" height="240" alt="Screen shot of Saving Lives with Peer Support video: IDEA Exchange; photo of Chetwyn "Arrow" Archer with his head bowed down and arms crossed on his chest. He has a down arrow drawn on his head and an up arrow on each hand and arm.">
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<p style="margin-bottom:1.2rem;margin-top:-.6rem;"><a href="/videos/saving-lives-peer-support"><span class="text-button-embed">Watch the video</span></a></p></div>
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<div class="visually-hidden">Related Topic Pages</div>
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<div><span>Overdose Reversal Medications </span></div>
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<a href="/publications/drugfacts/naloxone">
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<span>Naloxone DrugFacts</span>
|
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</h2>
|
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<p class="text-small card-description">
|
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Naloxone can quickly restore normal breathing to a person during an opioid overdose.
|
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<a href="/about-nida/noras-blog/2024/07/we-should-leverage-successes-hiv-care-to-prevent-overdose-mortality">
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<div class="tags tag-newspaper"><a href="/about-nida/noras-blog">Nora's Blog</a></div>
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<a href="/about-nida/noras-blog/2024/07/we-should-leverage-successes-hiv-care-to-prevent-overdose-mortality" rel="bookmark">
|
||
<span>We should leverage the successes of HIV care to prevent overdose mortality</span>
|
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</a>
|
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</h3>
|
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<div class="media-item-blurb text-small desktop-only">
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<span class="meta-data date text-small">
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<time datetime="2024-07-22T12:00:00Z">July 22, 2024</time>
|
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</span> |
|
||
Clinicians serving people living with HIV have a critical role to play in preventing overdose deaths
|
||
|
||
|
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</div>
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<a href="/news-events/news-releases/2023/06/xylazine-appears-to-worsen-the-life-threatening-effects-of-opioids-in-rats">
|
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<div><div class="featured-card">
|
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<div class="visually-hidden">Image</div>
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<div> <img loading="lazy" src="/sites/default/files/styles/featured_card/public/images/gettyimages-1466064793.optimized.jpg?h=199d8c1f&itok=c6UyE9Uj" width="600" height="400" alt="Rear view of woman at the golden hour looking at the setting sun filtering through her raised hand." />
|
||
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<a href="/news-events/news-releases/2023/06/xylazine-appears-to-worsen-the-life-threatening-effects-of-opioids-in-rats" rel="bookmark">
|
||
<span>Xylazine appears to worsen the life-threatening effects of opioids in rats</span>
|
||
</a>
|
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</h3>
|
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|
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<div class="media-item-blurb text-small desktop-only">
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<span class="meta-data date text-small">
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||
<time datetime="2023-06-20T12:00:00Z">June 20, 2023</time>
|
||
</span> |
|
||
NIH study deepens understanding of possible mechanism through which xylazine impacts overdose risk
|
||
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||
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</div>
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</div>
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<article data-history-node-id="50388">
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|
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<a href="/news-events/news-releases/2023/01/overdose-deaths-involving-buprenorphine-did-not-proportionally-increase-with-new-flexibilities-in-prescribing">
|
||
|
||
<div><div class="featured-card">
|
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<div class="visually-hidden">Image</div>
|
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<div> <img loading="lazy" src="/sites/default/files/styles/featured_card/public/images/man-on-yoga-mat.jpg?h=1c9b88c9&itok=rrpg2KF9" width="600" height="400" alt="A man sitting cross-legged and meditating in a yoga class." />
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</div>
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</a>
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</div>
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<div class="media-item-content col-8">
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<div class="tags tag-newspaper"><a href="/news-events/news-releases">News Release</a></div>
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<h3 class="media-item-title">
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<a href="/news-events/news-releases/2023/01/overdose-deaths-involving-buprenorphine-did-not-proportionally-increase-with-new-flexibilities-in-prescribing" rel="bookmark">
|
||
<span>Overdose deaths involving buprenorphine did not proportionally increase with new flexibilities in prescribing</span>
|
||
</a>
|
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</h3>
|
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|
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<div class="media-item-blurb text-small desktop-only">
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<span class="meta-data date text-small">
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<time datetime="2023-01-20T12:00:00Z">January 20, 2023</time>
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</span> |
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