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{"id":9460,"date":"2022-09-15T13:19:44","date_gmt":"2022-09-15T17:19:44","guid":{"rendered":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/?p=9460"},"modified":"2022-09-15T13:19:44","modified_gmt":"2022-09-15T17:19:44","slug":"hmm-release-10","status":"publish","type":"post","link":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2022\/09\/15\/hmm-release-10\/","title":{"rendered":"NCBI hidden Markov models (HMM) release 10.0 now available!"},"content":{"rendered":"<p>Release 10.0 of the NCBI Hidden Markov models (HMM) used by the Prokaryotic Genome Annotation Pipeline (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/genome\/annotation_prok\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=hmm-release-10-20220915\">PGAP<\/a>) is now available for <a href=\"https:\/\/ftp.ncbi.nlm.nih.gov\/hmm\/10.0\">download<\/a>. You can search this collection against your favorite prokaryotic proteins to identify their function using the <a href=\"http:\/\/eddylab.org\/software\/hmmer\/Userguide.pdf\">HMMER<\/a> sequence analysis package.<\/p>\n<p>The 10.0 release contains 15,360 models maintained by NCBI, including 228 that are new since 9.0, 99 that were modified significantly, and 205 that were assigned better names, EC numbers, <a href=\"http:\/\/geneontology.org\/\">Gene Ontology<\/a> (GO) terms, gene symbols or publications. You can search and view the details for these in the <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/protfam?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=hmm-release-10-20220915\">Protein Family Model<\/a> collection, which also includes conserved domain architectures and BlastRules, and find all <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/refseq\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=hmm-release-10-20220915\">RefSeq<\/a> proteins they name.<\/p>\n<p>GO terms associated with HMMs are now propagated to CDSs and proteins annotated with PGAP. In case you missed it, see our <a href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2022\/02\/24\/gene-ontology-refseq\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=hmm-release-10-20220915\">previous blog post<\/a> on this topic.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Release 10.0 of the NCBI Hidden Markov models (HMM) used by the Prokaryotic Genome Annotation Pipeline (PGAP) is now available for download. You can search this collection against your favorite prokaryotic proteins to identify their function using the HMMER sequence analysis package. The 10.0 release contains 15,360 models maintained by NCBI, including 228 that are … <a href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2022\/09\/15\/hmm-release-10\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">NCBI hidden Markov models (HMM) release 10.0 now available!<\/span> <span class=\"meta-nav\">→<\/span><\/a><\/p>\n","protected":false},"author":42204617,"featured_media":9462,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"NCBI hidden Markov models (HMM) release 10.0 now available!","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2248],"tags":[693060756,693060700,693060701,15779425,3995510,576953096],"table_tags":[],"class_list":["post-9460","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-whats-new","tag-gene-ontology-go","tag-hidden-markov-models-hmm","tag-hmmer","tag-pgap","tag-prokaryotes","tag-prokaryotic-genome-annotation"],"jetpack_publicize_connections":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>NCBI hidden Markov models (HMM) release 10.0 now available! - NCBI Insights<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2022\/09\/15\/hmm-release-10\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NCBI hidden Markov models (HMM) release 10.0 now available! - NCBI Insights\" \/>\n<meta property=\"og:description\" content=\"Release 10.0 of the NCBI Hidden Markov models (HMM) used by the Prokaryotic Genome Annotation Pipeline (PGAP) is now available for download. You can search this collection against your favorite prokaryotic proteins to identify their function using the HMMER sequence analysis package. The 10.0 release contains 15,360 models maintained by NCBI, including 228 that are … Continue reading NCBI hidden Markov models (HMM) release 10.0 now available! →\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2022\/09\/15\/hmm-release-10\/\" \/>\n<meta property=\"og:site_name\" content=\"NCBI Insights\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ncbi.nlm\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-15T17:19:44+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2022\/09\/HMM-release-10-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1086\" \/>\n\t<meta property=\"og:image:height\" content=\"237\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"NCBI Staff\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@NCBI\" \/>\n<meta name=\"twitter:site\" content=\"@NCBI\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"NCBI Staff\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2022\/09\/15\/hmm-release-10\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2022\/09\/15\/hmm-release-10\/\"},\"author\":{\"name\":\"NCBI Staff\",\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/#\/schema\/person\/4f41ea6a31cea38a9a1b1419c048e50b\"},\"headline\":\"NCBI hidden Markov models (HMM) release 10.0 now available!\",\"datePublished\":\"2022-09-15T17:19:44+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2022\/09\/15\/hmm-release-10\/\"},\"wordCount\":139,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/#organization\"},\"image\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2022\/09\/15\/hmm-release-10\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2022\/09\/HMM-release-10-1.png?fit=1086%2C237&ssl=1\",\"keywords\":[\"Gene Ontology (GO)\",\"Hidden Markov Models (HMM)\",\"HMMER\",\"NCBI Prokaryotic Genome Annotation Pipeline (PGAP)\",\"Prokaryotes\",\"Prokaryotic genome annotation\"],\"articleSection\":[\"What's New\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2022\/09\/15\/hmm-release-10\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2022\/09\/15\/hmm-release-10\/\",\"url\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2022\/09\/15\/hmm-release-10\/\",\"name\":\"NCBI hidden Markov models (HMM) release 10.0 now available! 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