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{"id":7972,"date":"2022-03-31T10:10:47","date_gmt":"2022-03-31T14:10:47","guid":{"rendered":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/?p=7972"},"modified":"2022-03-31T10:10:47","modified_gmt":"2022-03-31T14:10:47","slug":"ncbi-hmm-8-0","status":"publish","type":"post","link":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2022\/03\/31\/ncbi-hmm-8-0\/","title":{"rendered":"NCBI hidden Markov models (HMM) release 8.0 now available!"},"content":{"rendered":"<p>Release 8.0 of the NCBI Hidden Markov models (HMM), used by the Prokaryotic Genome Annotation Pipeline (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/genome\/annotation_prok\/?utm_source=blog&utm_medium=referral&utm_campaign=genome-annotation&utm_term=hmm&utm_content=20220331link1\">PGAP<\/a>), is now available for <a href=\"https:\/\/ftp.ncbi.nlm.nih.gov\/hmm\/8.0\">download<\/a>. You can search this collection against your favorite prokaryotic proteins to identify their function using the <a href=\"http:\/\/eddylab.org\/software\/hmmer\/Userguide.pdf\">HMMER<\/a> sequence analysis package.<\/p>\n<p>The 8.0 release contains 15,358 models, including 160 that are new since 7.0. In addition, we have added better names, EC numbers, <a href=\"http:\/\/geneontology.org\/\">Gene Ontology<\/a> (GO) terms, gene symbols or publications to over 550 existing HMMs. You can search and view the details for these in the <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/protfam?utm_source=blog&utm_medium=referral&utm_campaign=genome-annotation&utm_term=hmm&utm_content=20220331link2\">Protein Family Model collection<\/a>, which also includes conserved domain architectures and BlastRules, and find all RefSeq proteins they name.<\/p>\n<p>GO terms associated with HMMs are now propagated to\u00a0 coding sequences and proteins annotated with PGAP. In case you missed it, see our <a href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2022\/02\/24\/gene-ontology-refseq\/\">previous blog post<\/a> on this topic.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Release 8.0 of the NCBI Hidden Markov models (HMM), used by the Prokaryotic Genome Annotation Pipeline (PGAP), is now available for download. You can search this collection against your favorite prokaryotic proteins to identify their function using the HMMER sequence analysis package. The 8.0 release contains 15,358 models, including 160 that are new since 7.0. … <a href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2022\/03\/31\/ncbi-hmm-8-0\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">NCBI hidden Markov models (HMM) release 8.0 now available!<\/span> <span class=\"meta-nav\">→<\/span><\/a><\/p>\n","protected":false},"author":42204617,"featured_media":7987,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2248],"tags":[693060756,693060700,693060701,15779425,3995510,576953096],"table_tags":[],"class_list":["post-7972","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-whats-new","tag-gene-ontology-go","tag-hidden-markov-models-hmm","tag-hmmer","tag-pgap","tag-prokaryotes","tag-prokaryotic-genome-annotation"],"jetpack_publicize_connections":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>NCBI hidden Markov models (HMM) release 8.0 now available! - NCBI Insights<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2022\/03\/31\/ncbi-hmm-8-0\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NCBI hidden Markov models (HMM) release 8.0 now available! - NCBI Insights\" \/>\n<meta property=\"og:description\" content=\"Release 8.0 of the NCBI Hidden Markov models (HMM), used by the Prokaryotic Genome Annotation Pipeline (PGAP), is now available for download. You can search this collection against your favorite prokaryotic proteins to identify their function using the HMMER sequence analysis package. The 8.0 release contains 15,358 models, including 160 that are new since 7.0. … Continue reading NCBI hidden Markov models (HMM) release 8.0 now available! →\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2022\/03\/31\/ncbi-hmm-8-0\/\" \/>\n<meta property=\"og:site_name\" content=\"NCBI Insights\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ncbi.nlm\" \/>\n<meta property=\"article:published_time\" content=\"2022-03-31T14:10:47+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2022\/03\/HMM_8.0.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1062\" \/>\n\t<meta property=\"og:image:height\" content=\"234\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"NCBI Staff\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@NCBI\" \/>\n<meta name=\"twitter:site\" content=\"@NCBI\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"NCBI Staff\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2022\/03\/31\/ncbi-hmm-8-0\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2022\/03\/31\/ncbi-hmm-8-0\/\"},\"author\":{\"name\":\"NCBI Staff\",\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/#\/schema\/person\/4f41ea6a31cea38a9a1b1419c048e50b\"},\"headline\":\"NCBI hidden Markov models (HMM) release 8.0 now available!\",\"datePublished\":\"2022-03-31T14:10:47+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2022\/03\/31\/ncbi-hmm-8-0\/\"},\"wordCount\":138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/#organization\"},\"image\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2022\/03\/31\/ncbi-hmm-8-0\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2022\/03\/HMM_8.0.png?fit=1062%2C234&ssl=1\",\"keywords\":[\"Gene Ontology (GO)\",\"Hidden Markov Models (HMM)\",\"HMMER\",\"NCBI Prokaryotic Genome Annotation Pipeline (PGAP)\",\"Prokaryotes\",\"Prokaryotic genome annotation\"],\"articleSection\":[\"What's New\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2022\/03\/31\/ncbi-hmm-8-0\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2022\/03\/31\/ncbi-hmm-8-0\/\",\"url\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2022\/03\/31\/ncbi-hmm-8-0\/\",\"name\":\"NCBI hidden Markov models (HMM) release 8.0 now available! 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