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{"id":14200,"date":"2024-11-21T10:12:58","date_gmt":"2024-11-21T15:12:58","guid":{"rendered":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/?p=14200"},"modified":"2024-11-21T10:30:41","modified_gmt":"2024-11-21T15:30:41","slug":"explore-3d-molecular-structures-icn3d","status":"publish","type":"post","link":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/11\/21\/explore-3d-molecular-structures-icn3d\/","title":{"rendered":"Explore 3D Molecular Structures with iCn3D"},"content":{"rendered":"<p><span data-contrast=\"auto\">Do you want to analyze three-dimensional structures and highlight important features like active site residues, point mutations, and binding partners? Check out <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/Structure\/icn3d\/icn3d.html?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=icn3d-20241121\"><span data-contrast=\"none\">NCBI\u2019s \u201cI see in 3D\u201d (iCn3D)<\/span><\/a><span data-contrast=\"auto\"> \u2013 a free, web-based tool that allows you to explore the structure of a biomolecule at an atomistic level.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h5><b><span data-contrast=\"auto\">Features & Benefits<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h5>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"\uf0b7","469777815":"hybridMultilevel"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span style=\"font-size: 17px;\">Interactively view 3D structure and corresponding sequence data\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"\uf0b7","469777815":"hybridMultilevel"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span style=\"font-size: 17px;\">Align a protein sequence with unknown structure to a sequence-similar 3D structure\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"\uf0b7","469777815":"hybridMultilevel"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span style=\"font-size: 17px;\">Interactively view 3D alignments of similar structures\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"\uf0b7","469777815":"hybridMultilevel"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span style=\"font-size: 17px;\">View the interaction interfaces in a structure\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"\uf0b7","469777815":"hybridMultilevel"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span style=\"font-size: 17px;\">Save your custom display as a short URL or PNG image\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"\uf0b7","469777815":"hybridMultilevel"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span style=\"font-size: 17px;\">Share a link to your customized display of a structure\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"\uf0b7","469777815":"hybridMultilevel"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span style=\"font-size: 17px;\">Incorporate iCn3D into your own pages\u00a0<\/span><\/li>\n<\/ul>\n<p><!--more--><\/p>\n<h5>Example<\/h5>\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"14210\" data-permalink=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/11\/21\/explore-3d-molecular-structures-icn3d\/alphafold_catalase\/\" data-orig-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/11\/alphafold_catalase.jpg?fit=1280%2C720&ssl=1\" data-orig-size=\"1280,720\" data-comments-opened=\"1\" data-image-meta=\"{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}\" data-image-title=\"alphafold_catalase\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/11\/alphafold_catalase.jpg?fit=300%2C169&ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/11\/alphafold_catalase.jpg?fit=1024%2C576&ssl=1\" class=\"alignright size-full wp-image-14210\" src=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/11\/alphafold_catalase.jpg?resize=1108%2C623&ssl=1\" alt=\"iCn3D display of an AlphaFold predicted structure for human catalase, as retrieved via its RefSeq protein accession.\" width=\"1108\" height=\"623\" srcset=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/11\/alphafold_catalase.jpg?w=1280&ssl=1 1280w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/11\/alphafold_catalase.jpg?resize=300%2C169&ssl=1 300w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/11\/alphafold_catalase.jpg?resize=1024%2C576&ssl=1 1024w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/11\/alphafold_catalase.jpg?resize=150%2C84&ssl=1 150w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/11\/alphafold_catalase.jpg?resize=768%2C432&ssl=1 768w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/11\/alphafold_catalase.jpg?resize=270%2C152&ssl=1 270w\" sizes=\"auto, (max-width: 1108px) 100vw, 1108px\" \/><em><span class=\"TextRun SCXW147718727 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW147718727 BCX8\">Figure:<\/span><\/span> <a class=\"Hyperlink HyperlinkGateOff SCXW147718727 BCX8\" href=\"https:\/\/structure.ncbi.nlm.nih.gov\/icn3d\/share.html?4jeqN8NC7fNgkBfJ9\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"TextRun Underlined UnderlinedGateOff SCXW147718727 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW147718727 BCX8\" data-ccp-charstyle=\"Hyperlink\">iCn3D display<\/span><\/span><\/a><span class=\"TextRun SCXW147718727 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"> <span class=\"NormalTextRun SCXW147718727 BCX8\">of <\/span><span class=\"NormalTextRun SCXW147718727 BCX8\">an <\/span><\/span><span class=\"TextRun Highlight SCXW147718727 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW147718727 BCX8\">AlphaFold <\/span><span class=\"NormalTextRun SCXW147718727 BCX8\">predicted <\/span><span class=\"NormalTextRun SCXW147718727 BCX8\">structure for <\/span><span class=\"NormalTextRun SCXW147718727 BCX8\">human catalase, as retrieved via its<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW147718727 BCX8\">RefSeq<\/span><span class=\"NormalTextRun SCXW147718727 BCX8\"> protein accession<\/span><span class=\"NormalTextRun SCXW147718727 BCX8\">.<\/span> <span class=\"NormalTextRun SCXW147718727 BCX8\">A conserved sequence feature is mapped to the structure and highlighted<\/span><span class=\"NormalTextRun SCXW147718727 BCX8\">.<\/span><\/span><span class=\"EOP SCXW147718727 BCX8\" data-ccp-props=\"{}\">\u00a0<\/span><\/em><\/p>\n<p><span data-contrast=\"auto\">Check out our <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/Structure\/icn3d\/icn3d.html?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=icn3d-20241121#gallery\"><span data-contrast=\"none\">gallery<\/span><\/a><span data-contrast=\"auto\"> with live examples.\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h5><b><span data-contrast=\"auto\">Learn more<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h5>\n<p><span data-contrast=\"auto\">To learn more about iCn3D, read our <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/Structure\/icn3d\/docs\/icn3d_help.html?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=icn3d-20241121\"><span data-contrast=\"none\">help documentation<\/span><\/a> or reference our <a href=\"https:\/\/www.nlm.nih.gov\/ncbi\/workshops\/2024-07_ISMBHackathon-3d-molecular-structures\/workshop-details.html\">workshop materials<\/a>.<\/p>\n<h5><b><span data-contrast=\"auto\">Questions?<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h5>\n<p><span data-contrast=\"auto\">Please\u202f<\/span><a href=\"https:\/\/support.nlm.nih.gov\/support\/create-case\/\"><span data-contrast=\"none\">reach out to us<\/span><\/a><span data-contrast=\"none\">\u202f<\/span><span data-contrast=\"auto\">if you have questions or would like to provide feedback.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h5><b><span data-contrast=\"auto\">Stay up to date<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h5>\n<p><span data-contrast=\"auto\">Follow us on social\u202f<\/span><a href=\"https:\/\/twitter.com\/ncbi\"><span data-contrast=\"none\">@NCBI<\/span><\/a><span data-contrast=\"none\">\u202f<\/span><span data-contrast=\"auto\">and<\/span><span data-contrast=\"none\">\u202f<\/span><a href=\"https:\/\/public.govdelivery.com\/accounts\/USNLMOCPL\/subscriber\/new?topic_id=USNLMOCPL_52\"><span data-contrast=\"none\">join our mailing list<\/span><\/a><span data-contrast=\"none\">\u202f<\/span><span data-contrast=\"auto\">to keep up to date with\u202fiCn3D\u202fand other NCBI news.\u202f\u202f<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Do you want to analyze three-dimensional structures and highlight important features like active site residues, point mutations, and binding partners? Check out NCBI\u2019s \u201cI see in 3D\u201d (iCn3D) \u2013 a free, web-based tool that allows you to explore the structure of a biomolecule at an atomistic level.\u00a0 Features & Benefits\u00a0 Interactively view 3D structure and … <a href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/11\/21\/explore-3d-molecular-structures-icn3d\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Explore 3D Molecular Structures with iCn3D<\/span> <span class=\"meta-nav\">→<\/span><\/a><\/p>\n","protected":false},"author":42204617,"featured_media":14203,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"Explore 3D Molecular Structures with iCn3D","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2248],"tags":[683403471],"table_tags":[],"class_list":["post-14200","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-whats-new","tag-icn3d"],"jetpack_publicize_connections":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Explore 3D Molecular Structures with iCn3D - NCBI Insights<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/11\/21\/explore-3d-molecular-structures-icn3d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Explore 3D Molecular Structures with iCn3D - NCBI Insights\" \/>\n<meta property=\"og:description\" content=\"Do you want to analyze three-dimensional structures and highlight important features like active site residues, point mutations, and binding partners? 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