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{"id":13132,"date":"2024-04-23T11:42:57","date_gmt":"2024-04-23T15:42:57","guid":{"rendered":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/?p=13132"},"modified":"2024-04-23T11:42:57","modified_gmt":"2024-04-23T15:42:57","slug":"ncbi-hidden-markov-models-hmm-release-15-0-now-available","status":"publish","type":"post","link":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/04\/23\/ncbi-hidden-markov-models-hmm-release-15-0-now-available\/","title":{"rendered":"NCBI Hidden Markov Models (HMM) Release 15.0 Now Available!"},"content":{"rendered":"<p>Download <a href=\"https:\/\/ftp.ncbi.nlm.nih.gov\/hmm\/15.0\/\">release 15.0<\/a> of the NCBI protein profile Hidden Markov models (HMMs) used by the <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/refseq\/annotation_prok\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=hmm-release-15-20240423\">Prokaryotic Genome Annotation Pipeline<\/a> (PGAP)! Search this collection against your favorite prokaryotic proteins to identify their function using the <a href=\"http:\/\/eddylab.org\/software\/hmmer\/Userguide.pdf\">HMMER sequence analysis<\/a> package.<\/p>\n<h5>What\u2019s New?<\/h5>\n<p>Release 15.0 contains:<\/p>\n<ul>\n<li><span style=\"font-size: 17px;\">16,667 HMMs maintained by NCBI<\/span><\/li>\n<li><span style=\"font-size: 17px;\">279 new HMMs since release 14.0<\/span><\/li>\n<li><span style=\"font-size: 17px;\">Several hundreds HMMs with better names, EC numbers, Gene Ontology (GO) terms, gene symbols, or publications.\u00a0<\/span><\/li>\n<\/ul>\n<p><!--more--><\/p>\n<p>You can search and view the details for these in the <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/protfam?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=hmm-release-15-20240423\">Protein Family Model<\/a> collection, which also includes conserved domain architectures and BlastRules, and access all <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/refseq\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=hmm-release-15-20240423\">RefSeq<\/a> proteins that these models name.<\/p>\n<h5>Stay up to date<\/h5>\n<p><span data-contrast=\"auto\">Follow us on social\u202f<\/span><a href=\"https:\/\/twitter.com\/ncbi\"><span data-contrast=\"auto\">@NCBI<\/span><\/a><span data-contrast=\"auto\">\u202fand\u202f<\/span><a href=\"https:\/\/public.govdelivery.com\/accounts\/USNLMOCPL\/subscriber\/new?topic_id=USNLMOCPL_52\"><span data-contrast=\"auto\">join our mailing list<\/span><\/a><span data-contrast=\"auto\">\u202fto keep up to date with\u202fHMM\u202fand other NCBI news.\u202f\u202f<\/span><span data-ccp-props=\"{"134233117":false,"134233118":false,"201341983":0,"335559738":150,"335559739":0,"335559740":240}\">\u00a0<\/span><span data-ccp-props=\"{"201341983":0,"335559739":160,"335559740":259}\">\u00a0<\/span><\/p>\n<h5>We want to hear from you!<\/h5>\n<p><span data-contrast=\"auto\">If you have questions or would like to provide feedback, please reach out to us at <a href=\"mailto:info@ncbi.nlm.nih.gov\">info@ncbi.nlm.nih.gov<\/a>.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Download release 15.0 of the NCBI protein profile Hidden Markov models (HMMs) used by the Prokaryotic Genome Annotation Pipeline (PGAP)! Search this collection against your favorite prokaryotic proteins to identify their function using the HMMER sequence analysis package. What\u2019s New? Release 15.0 contains: 16,667 HMMs maintained by NCBI 279 new HMMs since release 14.0 Several … <a href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/04\/23\/ncbi-hidden-markov-models-hmm-release-15-0-now-available\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">NCBI Hidden Markov Models (HMM) Release 15.0 Now Available!<\/span> <span class=\"meta-nav\">→<\/span><\/a><\/p>\n","protected":false},"author":42204617,"featured_media":13136,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"NCBI Hidden Markov Models (HMM) Release 15.0 Now Available!","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2248],"tags":[693060700,693060701,15779425,27739816],"table_tags":[],"class_list":["post-13132","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-whats-new","tag-hidden-markov-models-hmm","tag-hmmer","tag-pgap","tag-refseq"],"jetpack_publicize_connections":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>NCBI Hidden Markov Models (HMM) Release 15.0 Now Available! - NCBI Insights<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/04\/23\/ncbi-hidden-markov-models-hmm-release-15-0-now-available\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NCBI Hidden Markov Models (HMM) Release 15.0 Now Available! - NCBI Insights\" \/>\n<meta property=\"og:description\" content=\"Download release 15.0 of the NCBI protein profile Hidden Markov models (HMMs) used by the Prokaryotic Genome Annotation Pipeline (PGAP)! Search this collection against your favorite prokaryotic proteins to identify their function using the HMMER sequence analysis package. What\u2019s New? Release 15.0 contains: 16,667 HMMs maintained by NCBI 279 new HMMs since release 14.0 Several … Continue reading NCBI Hidden Markov Models (HMM) Release 15.0 Now Available! →\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/04\/23\/ncbi-hidden-markov-models-hmm-release-15-0-now-available\/\" \/>\n<meta property=\"og:site_name\" content=\"NCBI Insights\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ncbi.nlm\" \/>\n<meta property=\"article:published_time\" content=\"2024-04-23T15:42:57+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/04\/HMM_Release-7-e1713460991510.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1100\" \/>\n\t<meta property=\"og:image:height\" content=\"575\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"NCBI Staff\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@NCBI\" \/>\n<meta name=\"twitter:site\" content=\"@NCBI\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"NCBI Staff\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/04\/23\/ncbi-hidden-markov-models-hmm-release-15-0-now-available\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/04\/23\/ncbi-hidden-markov-models-hmm-release-15-0-now-available\/\"},\"author\":{\"name\":\"NCBI Staff\",\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/#\/schema\/person\/4f41ea6a31cea38a9a1b1419c048e50b\"},\"headline\":\"NCBI Hidden Markov Models (HMM) Release 15.0 Now Available!\",\"datePublished\":\"2024-04-23T15:42:57+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/04\/23\/ncbi-hidden-markov-models-hmm-release-15-0-now-available\/\"},\"wordCount\":158,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/#organization\"},\"image\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/04\/23\/ncbi-hidden-markov-models-hmm-release-15-0-now-available\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/04\/HMM_Release-7-e1713460991510.png?fit=1100%2C575&ssl=1\",\"keywords\":[\"Hidden Markov Models (HMM)\",\"HMMER\",\"NCBI Prokaryotic Genome Annotation Pipeline (PGAP)\",\"RefSeq\"],\"articleSection\":[\"What's New\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/04\/23\/ncbi-hidden-markov-models-hmm-release-15-0-now-available\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/04\/23\/ncbi-hidden-markov-models-hmm-release-15-0-now-available\/\",\"url\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/04\/23\/ncbi-hidden-markov-models-hmm-release-15-0-now-available\/\",\"name\":\"NCBI Hidden Markov Models (HMM) Release 15.0 Now Available! - NCBI Insights\",\"isPartOf\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/04\/23\/ncbi-hidden-markov-models-hmm-release-15-0-now-available\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/04\/23\/ncbi-hidden-markov-models-hmm-release-15-0-now-available\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/04\/HMM_Release-7-e1713460991510.png?fit=1100%2C575&ssl=1\",\"datePublished\":\"2024-04-23T15:42:57+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/04\/23\/ncbi-hidden-markov-models-hmm-release-15-0-now-available\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/04\/23\/ncbi-hidden-markov-models-hmm-release-15-0-now-available\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/04\/23\/ncbi-hidden-markov-models-hmm-release-15-0-now-available\/#primaryimage\",\"url\":\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/04\/HMM_Release-7-e1713460991510.png?fit=1100%2C575&ssl=1\",\"contentUrl\":\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/04\/HMM_Release-7-e1713460991510.png?fit=1100%2C575&ssl=1\",\"width\":1100,\"height\":575,\"caption\":\"Colorful squares stacked in the background with letters in them. 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Search this collection against your favorite prokaryotic proteins to identify their function using the HMMER sequence analysis package. What\u2019s New? 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