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{"id":12743,"date":"2024-01-31T12:13:23","date_gmt":"2024-01-31T17:13:23","guid":{"rendered":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/?p=12743"},"modified":"2024-09-18T10:11:24","modified_gmt":"2024-09-18T14:11:24","slug":"enhancements-clinvar-website-live","status":"publish","type":"post","link":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/01\/31\/enhancements-clinvar-website-live\/","title":{"rendered":"Enhancements to ClinVar Website Now Live"},"content":{"rendered":"<div class=\"wptb-table-container wptb-table-12853\"><div class=\"wptb-table-container-matrix\" id=\"wptb-table-id-12853\" data-wptb-version=\"2.0.2\" data-wptb-pro-status=\"false\"><table class=\"wptb-preview-table wptb-element-main-table_setting-12853\" style=\"border-spacing: 3px 3px; border: 1px solid rgb(209, 209, 209); \" data-reconstraction=\"1\" data-wptb-cells-width-auto-count=\"1\" data-wptb-horizontal-scroll-status=\"false\" data-wptb-extra-styles=\"LyogRW50ZXIgeW91ciBjdXN0b20gQ1NTIHJ1bGVzIGhlcmUgKi8=\" data-wptb-pro-pagination-top-row-header=\"false\" data-wptb-rows-per-page=\"10\" data-wptb-pro-search-top-row-header=\"false\" data-wptb-searchbar-position=\"left\" role=\"table\" data-table-columns=\"1\" data-wptb-table-alignment=\"center\" data-wptb-table-tds-sum-max-width=\"131.60000000000002\"><tbody data-global-font-color=\"#000000\" data-global-link-color=\"#000000\" data-global-font-size=\"15\"><tr class=\"wptb-row \" style=\"\"><td class=\"wptb-cell \" style=\"border: 1px solid rgb(209, 209, 209); \" data-y-index=\"0\" data-x-index=\"0\" data-wptb-css-td-auto-width=\"true\" data-wptb-cell-vertical-alignment=\"center\"><div class=\"wptb-text-container wptb-ph-element wptb-element-text-597\" style=\"color: rgb(0, 0, 0); font-size: 17px; \"><div style=\"position: relative;\"><p><strong>Important Note:<\/strong> Support for both the old XML formats has been extended through the end of December 2024.&nbsp;To prepare for these changes, please preview the updated&nbsp;<a data-mce-href=\"https:\/\/github.com\/ncbi\/clinvar\/tree\/master\/xsds_preview\" href=\"https:\/\/github.com\/ncbi\/clinvar\/tree\/master\/xsds_preview\">XML schema<\/a>&nbsp;and supporting documentation on&nbsp;<a data-mce-href=\"https:\/\/github.com\/ncbi\/clinvar\" href=\"https:\/\/github.com\/ncbi\/clinvar\" data-mce-selected=\"inline-boundary\">GitHub<\/a>.<\/p><\/div><\/div><\/td><\/tr><\/tbody><\/table><\/div><\/div>\n\n<p><span data-contrast=\"auto\">As <\/span><a href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/11\/28\/updates-clinvar-website\/?utm_source=ncbi_insights&amp;utm_medium=referral&amp;utm_campaign=clinvar-updates-20240131\"><span data-contrast=\"none\">previously announced<\/span><\/a><span data-contrast=\"auto\">, we updated the ClinVar website as part of our effort to better support the display of submitted <\/span><a href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/02\/01\/clinvar-support-for-somatic-data\/?utm_source=ncbi_insights&amp;utm_medium=referral&amp;utm_campaign=clinvar-updates-20240131\"><span data-contrast=\"none\">somatic variation data<\/span><\/a><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<h5 aria-level=\"5\"><b><span data-contrast=\"auto\">What changed?<\/span><\/b><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/h5>\n<p><!--more--><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span style=\"font-size: 16px;\"><span style=\"font-size: 17px;\">Updated ClinVar search results<\/span><\/span>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span style=\"font-size: 17px;\">Germline \/ Somatic origin filter<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span style=\"font-size: 17px;\">Somatic Classification and Review Status summary<\/span><\/li>\n<\/ul>\n<\/li>\n<li><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"12766\" data-permalink=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/01\/31\/enhancements-clinvar-website-live\/clinvar_somatic_search\/\" data-orig-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/01\/Clinvar_somatic_search.png?fit=1852%2C779&amp;ssl=1\" data-orig-size=\"1852,779\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Clinvar_somatic_search\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/01\/Clinvar_somatic_search.png?fit=300%2C126&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/01\/Clinvar_somatic_search.png?fit=1024%2C431&amp;ssl=1\" class=\"alignright size-full wp-image-12766\" src=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/01\/Clinvar_somatic_search.png?resize=1108%2C466&#038;ssl=1\" alt=\"Screenshot of the ClinVar somatic search.\" width=\"1108\" height=\"466\" srcset=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/01\/Clinvar_somatic_search.png?w=1852&amp;ssl=1 1852w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/01\/Clinvar_somatic_search.png?resize=300%2C126&amp;ssl=1 300w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/01\/Clinvar_somatic_search.png?resize=1024%2C431&amp;ssl=1 1024w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/01\/Clinvar_somatic_search.png?resize=150%2C63&amp;ssl=1 150w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/01\/Clinvar_somatic_search.png?resize=768%2C323&amp;ssl=1 768w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/01\/Clinvar_somatic_search.png?resize=1536%2C646&amp;ssl=1 1536w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/01\/Clinvar_somatic_search.png?resize=1200%2C505&amp;ssl=1 1200w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/01\/Clinvar_somatic_search.png?resize=270%2C114&amp;ssl=1 270w\" sizes=\"auto, (max-width: 1108px) 100vw, 1108px\" \/><span style=\"font-size: 17px;\">Updated Variant (VCV)\u00a0 record page<\/span>\n<ul>\n<li><span style=\"font-size: 17px;\">Includes both Germline and Somatic data for the same variant<\/span><\/li>\n<li><span style=\"font-size: 17px;\">Switch to turn on\/off Somatic or Germline information<\/span><\/li>\n<\/ul>\n<\/li>\n<li><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"12784\" data-permalink=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/01\/31\/enhancements-clinvar-website-live\/comm-16160-clinvar-somatic-1\/\" data-orig-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/01\/COMM-16160-Clinvar-somatic-1.png?fit=1081%2C993&amp;ssl=1\" data-orig-size=\"1081,993\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"COMM-16160-Clinvar-somatic (1)\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/01\/COMM-16160-Clinvar-somatic-1.png?fit=300%2C276&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/01\/COMM-16160-Clinvar-somatic-1.png?fit=1024%2C941&amp;ssl=1\" class=\"alignright size-full wp-image-12784\" src=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/01\/COMM-16160-Clinvar-somatic-1.png?resize=1081%2C993&#038;ssl=1\" alt=\"Screenshot of ClinVar search results page updated filter \" width=\"1081\" height=\"993\" srcset=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/01\/COMM-16160-Clinvar-somatic-1.png?w=1081&amp;ssl=1 1081w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/01\/COMM-16160-Clinvar-somatic-1.png?resize=300%2C276&amp;ssl=1 300w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/01\/COMM-16160-Clinvar-somatic-1.png?resize=1024%2C941&amp;ssl=1 1024w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/01\/COMM-16160-Clinvar-somatic-1.png?resize=150%2C138&amp;ssl=1 150w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/01\/COMM-16160-Clinvar-somatic-1.png?resize=768%2C705&amp;ssl=1 768w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/01\/COMM-16160-Clinvar-somatic-1.png?resize=270%2C248&amp;ssl=1 270w\" sizes=\"auto, (max-width: 1081px) 100vw, 1081px\" \/><span style=\"font-size: 17px;\">Efetch command within E-utilities\u00a0<\/span>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span style=\"font-size: 17px;\">By default, the E-utilities efetch command now retrieves the new XML with support for somatic variant<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span style=\"font-size: 17px;\">Include the parameter old_xml=T in EFetch calls to get the old XML<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span style=\"font-size: 17px;\"> Support for both new and old XML formats through the end of March 2024<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><b><span data-contrast=\"auto\">Important note:<\/span><\/b><span data-contrast=\"auto\"> These screenshots include test data and is not intended to represent real variants. But we are ready for your submissions of somatic variation data!<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559738&quot;:150,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<h5 aria-level=\"5\">Learn more<\/h5>\n<p><span data-contrast=\"auto\">For more information about our recent updates to the ClinVar website, check out our <a href=\"https:\/\/ftp.ncbi.nlm.nih.gov\/pub\/clinvar\/release_notes\/20240129WebRelease.pdf\">release notes<\/a>.\u00a0<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<h5 aria-level=\"5\">Stay up to date<\/h5>\n<p><span data-contrast=\"auto\">Follow us on social\u202f<\/span><a href=\"https:\/\/twitter.com\/ncbi\"><span data-contrast=\"auto\">@NCBI<\/span><\/a><span data-contrast=\"auto\">\u202fand\u202f<\/span><a href=\"https:\/\/public.govdelivery.com\/accounts\/USNLMOCPL\/subscriber\/new?topic_id=USNLMOCPL_52\"><span data-contrast=\"auto\">join our mailing list<\/span><\/a><span data-contrast=\"auto\">\u202fto keep up to date with\u202fClinVar\u202fand other NCBI news.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<h5 aria-level=\"5\">Questions?<\/h5>\n<p><span data-contrast=\"auto\">If you have questions or would like to provide feedback, please reach out to us at <\/span><a href=\"mailto:clinvar@ncbi.nlm.nih.gov\"><span data-contrast=\"auto\">clinvar@ncbi.nlm.nih.gov<\/span><\/a><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>As previously announced, we updated the ClinVar website as part of our effort to better support the display of submitted somatic variation data.\u00a0 What changed?\u00a0<\/p>\n","protected":false},"author":42204617,"featured_media":12746,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"Enhancements to ClinVar Website Now Live","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2248],"tags":[108204782],"table_tags":[],"class_list":["post-12743","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-whats-new","tag-clinvar"],"jetpack_publicize_connections":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.6 - 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