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{"id":12225,"date":"2023-09-29T15:32:10","date_gmt":"2023-09-29T19:32:10","guid":{"rendered":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/?p=12225"},"modified":"2023-10-16T11:08:50","modified_gmt":"2023-10-16T15:08:50","slug":"comparing-yeast-species-beer","status":"publish","type":"post","link":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/09\/29\/comparing-yeast-species-beer\/","title":{"rendered":"Comparing Yeast Species Used in Beer Brewing and Bread Making"},"content":{"rendered":"<h3><i><span data-contrast=\"none\">Using the NIH Comparative Genomics Resource (CGR) to gain knowledge about less-researched\u00a0organisms<\/span><\/i><span data-ccp-props=\"{"201341983":0,"335559739":160,"335559740":259}\">\u00a0<\/span><\/h3>\n<p><span data-contrast=\"auto\">The scientific community relies heavily on model organism research to gain knowledge and make discoveries. However, focusing solely on these species misses valuable variation. Comparative genomics allows us to use knowledge from a model species, such as <\/span><i><span data-contrast=\"auto\">Saccharomyces cerevisiae,<\/span><\/i><span data-contrast=\"auto\"> to understand traits in other, related organisms, such as <\/span><i><span data-contrast=\"auto\">Saccharomyces pastorianus or Saccharomyces eubayanus<\/span><\/i><span data-contrast=\"auto\">. Applying this information may provide valuable insight for other less-researched organisms. <\/span><span data-contrast=\"none\">The National Institutes of Health (NIH) <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/comparative-genomics-resource\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=cgr-use-case-yeast-20230929\"><span data-contrast=\"none\">Comparative Genomics Resource (CGR)<\/span><\/a><span data-contrast=\"none\"> offers a cutting-edge NCBI toolkit of high-quality genomics data and tools to help you do just that.<\/span><span data-ccp-props=\"{"201341983":0,"335559739":160,"335559740":257}\">\u00a0<\/span><!--more--><\/p>\n<h5>How and why should you use our resources? Consider the example below.<\/h5>\n<p><span data-contrast=\"auto\">Yeast has been used in beer brewing and bread baking for millennia. The specific species of yeast (<\/span><i><span data-contrast=\"auto\">Saccharomyces cerevisiae<\/span><\/i><span data-contrast=\"auto\">) traditionally used to make beer, bread, and wine has been cultured and domesticated over time as a distinct species from other environmental yeasts.<\/span><span data-ccp-props=\"{"201341983":0,"335559739":160,"335559740":257}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Researchers used comparative genomics methods to uncover the origin of the yeast strain involved in lager-style beer production, <\/span><i><span data-contrast=\"auto\">Saccharomyces pastorianus (<\/span><\/i><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3167505\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=cgr-use-case-yeast-20230929\"><i><span data-contrast=\"none\">PMC316705<\/span><\/i><\/a><i><span data-contrast=\"auto\">)<\/span><\/i><span data-contrast=\"auto\">. They found that this organism was likely created by fusion of <\/span><i><span data-contrast=\"auto\">S. cerevisia<\/span><\/i><span data-contrast=\"auto\">e and the cold-hardy yeast, <\/span><i><span data-contrast=\"auto\">Saccharomyces eubayanus.\u00a0<\/span><\/i><span data-ccp-props=\"{"201341983":0,"335559739":160,"335559740":257}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">In addition to the ability to thrive in cold temperatures, <\/span><i><span data-contrast=\"auto\">S. pastorianu<\/span><\/i><span data-contrast=\"auto\">s is also better able to use some of the recipe’s barley malt sugars than <\/span><i><span data-contrast=\"auto\">S. cerevisiae<\/span><\/i><span data-contrast=\"auto\">. Leftover malt sugars are often used as a biomarker to differentiate between these two yeast species.<\/span><span data-ccp-props=\"{"201341983":0,"335559739":160,"335559740":257}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">The following are relevant CGR and other NCBI resources that facilitate comparisons between the well known <\/span><i><span data-contrast=\"none\">S. cerevisiae<\/span><\/i><span data-contrast=\"none\"> (Ale-style beer & bread yeast),<\/span> and the lesser-studied<span data-contrast=\"none\">\u00a0<\/span><i><span data-contrast=\"none\">S. pastorianus <\/span><\/i><span data-contrast=\"none\">(Lager-style beer yeast) or <\/span><i><span data-contrast=\"none\">S. eubayanus<\/span><\/i><span data-contrast=\"none\"> (cold-tolerant yeast)<\/span><span data-contrast=\"none\"> – from whole genome alignments down to the protein structure of the specific IMA1 sugar-metabolizing gene: <\/span><span data-ccp-props=\"{"201341983":0,"335559739":160,"335559740":259}\">\u00a0<\/span><\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"90\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"12235\" data-permalink=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/09\/29\/comparing-yeast-species-beer\/datasets-1\/\" data-orig-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/Datasets-1.png?fit=1200%2C1200&ssl=1\" data-orig-size=\"1200,1200\" data-comments-opened=\"1\" data-image-meta=\"{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}\" data-image-title=\"Datasets (1)\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/Datasets-1.png?fit=300%2C300&ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/Datasets-1.png?fit=1024%2C1024&ssl=1\" class=\"wp-image-12235 aligncenter\" src=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/Datasets-1.png?resize=70%2C70&ssl=1\" alt=\"shopping cart\" width=\"70\" height=\"70\" srcset=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/Datasets-1.png?w=1200&ssl=1 1200w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/Datasets-1.png?resize=300%2C300&ssl=1 300w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/Datasets-1.png?resize=1024%2C1024&ssl=1 1024w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/Datasets-1.png?resize=150%2C150&ssl=1 150w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/Datasets-1.png?resize=768%2C768&ssl=1 768w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/Datasets-1.png?resize=800%2C800&ssl=1 800w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/Datasets-1.png?resize=600%2C600&ssl=1 600w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/Datasets-1.png?resize=400%2C400&ssl=1 400w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/Datasets-1.png?resize=200%2C200&ssl=1 200w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/Datasets-1.png?resize=270%2C270&ssl=1 270w\" sizes=\"auto, (max-width: 70px) 100vw, 70px\" \/><\/td>\n<td width=\"534\"><span data-contrast=\"auto\">Find available genome data for<\/span> <a href=\"https:\/\/ncbi.nlm.nih.gov\/datasets\/genome\/GCF_000146045.2\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=cgr-use-case-yeast-20230929\"><i><span data-contrast=\"none\">S. cerevisiae <\/span><\/i><\/a><span data-contrast=\"auto\">and <\/span><a href=\"https:\/\/ncbi.nlm.nih.gov\/datasets\/genome\/GCA_011022315.1\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=cgr-use-case-yeast-20230929\"><i><span data-contrast=\"none\">S. pastorianus<\/span><\/i><\/a><span data-contrast=\"auto\"> or <\/span><a href=\"https:\/\/ncbi.nlm.nih.gov\/datasets\/genome\/GCF_001298625.1\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=cgr-use-case-yeast-20230929\"><i><span data-contrast=\"none\">S. eubayanus<\/span><\/i><\/a> <span data-contrast=\"auto\">with <\/span><a href=\"https:\/\/ncbi.nlm.nih.gov\/datasets\/genome?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=cgr-use-case-yeast-20230929\"><span data-contrast=\"none\">NCBI Datasets<\/span><\/a><span data-ccp-props=\"{"201341983":0,"335559739":160,"335559740":259}\">\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"90\"><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"11648\" data-permalink=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/06\/14\/canine-human-oncology-cgr\/cgv-6\/\" data-orig-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/06\/CGV-6.png?fit=1200%2C1200&ssl=1\" data-orig-size=\"1200,1200\" data-comments-opened=\"1\" data-image-meta=\"{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}\" data-image-title=\"CGV (6)\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/06\/CGV-6.png?fit=300%2C300&ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/06\/CGV-6.png?fit=1024%2C1024&ssl=1\" class=\"aligncenter wp-image-11648\" src=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/06\/CGV-6.png?resize=72%2C72&ssl=1\" sizes=\"auto, (max-width: 72px) 100vw, 72px\" srcset=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/06\/CGV-6.png?w=1200&ssl=1 1200w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/06\/CGV-6.png?resize=300%2C300&ssl=1 300w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/06\/CGV-6.png?resize=1024%2C1024&ssl=1 1024w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/06\/CGV-6.png?resize=150%2C150&ssl=1 150w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/06\/CGV-6.png?resize=768%2C768&ssl=1 768w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/06\/CGV-6.png?resize=800%2C800&ssl=1 800w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/06\/CGV-6.png?resize=400%2C400&ssl=1 400w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/06\/CGV-6.png?resize=200%2C200&ssl=1 200w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/06\/CGV-6.png?resize=270%2C270&ssl=1 270w\" alt=\"\" width=\"70\" height=\"70\" data-attachment-id=\"11648\" data-permalink=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/06\/14\/canine-human-oncology-cgr\/cgv-6\/\" data-orig-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/06\/CGV-6.png?fit=1200%2C1200&ssl=1\" data-orig-size=\"1200,1200\" data-comments-opened=\"1\" data-image-meta=\"{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}\" data-image-title=\"CGV (6)\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/06\/CGV-6.png?fit=300%2C300&ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/06\/CGV-6.png?fit=1024%2C1024&ssl=1\" \/><\/td>\n<td width=\"534\"><span data-contrast=\"auto\">Compare genomes of <\/span><a href=\"https:\/\/ncbi.nlm.nih.gov\/genome\/cgv\/browse\/GCA_011022315.1\/GCF_000146045.2\/37995\/559292?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=cgr-use-case-yeast-20230929#CP049004.1%3A1031088-1034800%2FNC_001139.9%3A1066247-1069959%2Fsize=10000\"><i><span data-contrast=\"none\">S. cerevisiae <\/span><\/i><span data-contrast=\"none\">&<\/span><i><span data-contrast=\"none\"> S. pastorianus<\/span><\/i><\/a><span data-contrast=\"auto\"> or<\/span> <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/genome\/cgv\/browse\/GCF_001298625.1\/GCA_011022315.1\/38015\/27292?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=cgr-use-case-yeast-20230929\"><i><span data-contrast=\"none\">S. pastorianus<\/span><\/i><span data-contrast=\"none\"> & <\/span><i><span data-contrast=\"none\">S. eubayanus<\/span><\/i><\/a><span data-contrast=\"auto\"> using the <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/genome\/cgv\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=cgr-use-case-yeast-20230929\">Comparative Genome Viewer (CGV)<\/a><\/span><span data-ccp-props=\"{"201341983":0,"335559739":160,"335559740":259}\">\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"90\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"12237\" data-permalink=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/09\/29\/comparing-yeast-species-beer\/msa_viewer-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/MSA_Viewer-2.png?fit=1200%2C1200&ssl=1\" data-orig-size=\"1200,1200\" data-comments-opened=\"1\" data-image-meta=\"{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}\" data-image-title=\"MSA_Viewer (2)\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/MSA_Viewer-2.png?fit=300%2C300&ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/MSA_Viewer-2.png?fit=1024%2C1024&ssl=1\" class=\"wp-image-12237 aligncenter\" src=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/MSA_Viewer-2.png?resize=70%2C70&ssl=1\" alt=\"\" width=\"70\" height=\"70\" srcset=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/MSA_Viewer-2.png?w=1200&ssl=1 1200w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/MSA_Viewer-2.png?resize=300%2C300&ssl=1 300w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/MSA_Viewer-2.png?resize=1024%2C1024&ssl=1 1024w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/MSA_Viewer-2.png?resize=150%2C150&ssl=1 150w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/MSA_Viewer-2.png?resize=768%2C768&ssl=1 768w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/MSA_Viewer-2.png?resize=800%2C800&ssl=1 800w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/MSA_Viewer-2.png?resize=600%2C600&ssl=1 600w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/MSA_Viewer-2.png?resize=400%2C400&ssl=1 400w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/MSA_Viewer-2.png?resize=200%2C200&ssl=1 200w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/MSA_Viewer-2.png?resize=270%2C270&ssl=1 270w\" sizes=\"auto, (max-width: 70px) 100vw, 70px\" \/><\/td>\n<td width=\"534\"><span data-contrast=\"auto\">Explore the alignment of the <\/span><i><span data-contrast=\"auto\">S. cerevisiae <\/span><\/i><span data-contrast=\"auto\">&<\/span><i><span data-contrast=\"auto\"> S. pastorianus<\/span><\/i><span data-contrast=\"auto\"> IMA1 sugar-metabolizing genes with the <a href=\"https:\/\/ncbi.nlm.nih.gov\/projects\/msaviewer\/?batch_id=37995&align_id=2921&anchor=CP049004.1&from=1031585&to=1035297&cgv=&utm_source=ncbi_insights&utm_medium=referral&utm_campaign=cgr-use-case-yeast-20230929\">Multiple Sequence Alignment (MSA) Viewer<\/a><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"90\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"12239\" data-permalink=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/09\/29\/comparing-yeast-species-beer\/gdv-4-1\/\" data-orig-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/GDV-4-1.png?fit=1200%2C1200&ssl=1\" data-orig-size=\"1200,1200\" data-comments-opened=\"1\" data-image-meta=\"{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}\" data-image-title=\"GDV (4) (1)\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/GDV-4-1.png?fit=300%2C300&ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/GDV-4-1.png?fit=1024%2C1024&ssl=1\" class=\"wp-image-12239 aligncenter\" src=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/GDV-4-1.png?resize=70%2C70&ssl=1\" alt=\"\" width=\"70\" height=\"70\" srcset=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/GDV-4-1.png?w=1200&ssl=1 1200w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/GDV-4-1.png?resize=300%2C300&ssl=1 300w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/GDV-4-1.png?resize=1024%2C1024&ssl=1 1024w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/GDV-4-1.png?resize=150%2C150&ssl=1 150w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/GDV-4-1.png?resize=768%2C768&ssl=1 768w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/GDV-4-1.png?resize=800%2C800&ssl=1 800w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/GDV-4-1.png?resize=600%2C600&ssl=1 600w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/GDV-4-1.png?resize=400%2C400&ssl=1 400w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/GDV-4-1.png?resize=200%2C200&ssl=1 200w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/GDV-4-1.png?resize=270%2C270&ssl=1 270w\" sizes=\"auto, (max-width: 70px) 100vw, 70px\" \/><\/td>\n<td width=\"534\"><span data-contrast=\"auto\">Identify sequence-level differences and conserved domains in the IMA1 sugar-metabolizing gene with the <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/genome\/gdv\/browser\/genome\/?cfg=NCID_1_226250_130.14.18.128_9146_1694718324_720852259\"><span data-contrast=\"none\">Genome Data Viewer (GDV)<\/span><\/a><span data-ccp-props=\"{"201341983":0,"335559739":160,"335559740":259}\">\u00a0<\/span><\/td>\n<\/tr>\n<tr data-wp-editing=\"1\">\n<td width=\"90\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"12241\" data-permalink=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/09\/29\/comparing-yeast-species-beer\/cdd-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/CDD.png?fit=1200%2C1200&ssl=1\" data-orig-size=\"1200,1200\" data-comments-opened=\"1\" data-image-meta=\"{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}\" data-image-title=\"CDD\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/CDD.png?fit=300%2C300&ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/CDD.png?fit=1024%2C1024&ssl=1\" class=\"wp-image-12241 aligncenter\" src=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/CDD.png?resize=70%2C70&ssl=1\" alt=\"shapes connected by a line\" width=\"70\" height=\"70\" srcset=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/CDD.png?w=1200&ssl=1 1200w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/CDD.png?resize=300%2C300&ssl=1 300w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/CDD.png?resize=1024%2C1024&ssl=1 1024w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/CDD.png?resize=150%2C150&ssl=1 150w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/CDD.png?resize=768%2C768&ssl=1 768w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/CDD.png?resize=800%2C800&ssl=1 800w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/CDD.png?resize=600%2C600&ssl=1 600w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/CDD.png?resize=400%2C400&ssl=1 400w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/CDD.png?resize=200%2C200&ssl=1 200w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/CDD.png?resize=270%2C270&ssl=1 270w\" sizes=\"auto, (max-width: 70px) 100vw, 70px\" \/><\/td>\n<td width=\"534\"><span data-contrast=\"auto\">Learn more about the largest functional domain in the IMA1 protein in <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/Structure\/cdd\/cddsrv.cgi?uid=200472&utm_source=ncbi_insights&utm_medium=referral&utm_campaign=cgr-use-case-yeast-20230929\"><span data-contrast=\"none\">Conserved Domain Database (CDD)<\/span><\/a><span data-ccp-props=\"{"201341983":0,"335559739":160,"335559740":259}\">\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"90\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"12243\" data-permalink=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/09\/29\/comparing-yeast-species-beer\/blast_icon-1\/\" data-orig-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/BLAST_Icon-1.png?fit=1200%2C1200&ssl=1\" data-orig-size=\"1200,1200\" data-comments-opened=\"1\" data-image-meta=\"{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}\" data-image-title=\"BLAST_Icon (1)\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/BLAST_Icon-1.png?fit=300%2C300&ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/BLAST_Icon-1.png?fit=1024%2C1024&ssl=1\" class=\"wp-image-12243 aligncenter\" src=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/BLAST_Icon-1.png?resize=70%2C70&ssl=1\" alt=\"drawing of a spaceship blasting off\" width=\"70\" height=\"70\" srcset=\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/BLAST_Icon-1.png?w=1200&ssl=1 1200w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/BLAST_Icon-1.png?resize=300%2C300&ssl=1 300w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/BLAST_Icon-1.png?resize=1024%2C1024&ssl=1 1024w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/BLAST_Icon-1.png?resize=150%2C150&ssl=1 150w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/BLAST_Icon-1.png?resize=768%2C768&ssl=1 768w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/BLAST_Icon-1.png?resize=800%2C800&ssl=1 800w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/BLAST_Icon-1.png?resize=600%2C600&ssl=1 600w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/BLAST_Icon-1.png?resize=400%2C400&ssl=1 400w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/BLAST_Icon-1.png?resize=200%2C200&ssl=1 200w, https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/09\/BLAST_Icon-1.png?resize=270%2C270&ssl=1 270w\" sizes=\"auto, (max-width: 70px) 100vw, 70px\" \/><\/td>\n<td width=\"534\"><span data-contrast=\"auto\">Use RefSeq protein sequence to find <\/span><a href=\"https:\/\/blast.ncbi.nlm.nih.gov\/Blast.cgi?CMD=Get&RID=GHDDUVHP016&utm_source=ncbi_insights&utm_medium=referral&utm_campaign=cgr-use-case-yeast-20230929\"><span data-contrast=\"none\">all sequences similar to IMA1 in the <\/span><i><span data-contrast=\"none\">S. pastorianus<\/span><\/i><span data-contrast=\"none\"> genome<\/span><\/a><span data-contrast=\"auto\"> using BLAST, and use <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/blast\/treeview\/treeView.cgi?request=page&blastRID=GHDDUVHP016&queryID=ref%7CNP_011803.3%7C&entrezLim=&ex=&exl=&exh=&ns=100&utm_source=ncbi_insights&utm_medium=referral&utm_campaign=cgr-use-case-yeast-20230929\"><span data-contrast=\"none\">Tree View to visualize their relatedness<\/span><\/a><span data-ccp-props=\"{"201341983":0,"335559739":160,"335559740":259}\">\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h5>Stay up to date<\/h5>\n<p><span data-contrast=\"auto\">Join our <\/span><a 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If you\u2019re interested in getting involved, reach out to us at cgr@nlm.nih.gov or visit <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/comparative-genomics-resource\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=cgr-use-case-yeast-20230929\"><span data-contrast=\"none\">our website<\/span><\/a><span data-contrast=\"auto\"> and click the yellow Feedback button on the bottom right.\u00a0\u00a0<\/span><span data-ccp-props=\"{"201341983":0,"335559739":160,"335559740":259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Using the NIH Comparative Genomics Resource (CGR) to gain knowledge about less-researched\u00a0organisms\u00a0 The scientific community relies heavily on model organism research to gain knowledge and make discoveries. However, focusing solely on these species misses valuable variation. Comparative genomics allows us to use knowledge from a model species, such as Saccharomyces cerevisiae, to understand traits in … <a href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/09\/29\/comparing-yeast-species-beer\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Comparing Yeast Species Used in Beer Brewing and Bread Making<\/span> <span class=\"meta-nav\">→<\/span><\/a><\/p>\n","protected":false},"author":42204617,"featured_media":12248,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"Comparing Yeast Species Used in Beer Brewing and Bread Making","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2248],"tags":[77187,693060769,693060768,144042800,693060686,574293891,556890977,27739816],"table_tags":[],"class_list":["post-12225","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-whats-new","tag-blast","tag-comparative-genome-viewer-cgv","tag-comparative-genomics-resource-cgr","tag-conserved-domains-database-cdd","tag-datasets","tag-genome-data-viewer","tag-multiple-sequence-alignment-viewer","tag-refseq"],"jetpack_publicize_connections":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Comparing Yeast Species Used in Beer Brewing and Bread Making - NCBI Insights<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/09\/29\/comparing-yeast-species-beer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Comparing Yeast Species Used in Beer Brewing and Bread Making - NCBI Insights\" \/>\n<meta property=\"og:description\" content=\"Using the NIH Comparative Genomics Resource (CGR) to gain knowledge about less-researched\u00a0organisms\u00a0 The scientific community relies heavily on model organism research to gain knowledge and make discoveries. 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