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We offer a variety of resources that you can use to better understand translational science and the challenges it is addressing.
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<div class="contact-box"><h4>Contact</h4><p><a href="mailto:amanda.vogel@nih.gov">Amanda Vogel, Ph.D., M.P.H.</a><br> </p><hr><p>Visit our <a href="/news-events/infographics-and-fact-sheets">Multimedia</a> page to learn more about translational science.</p></div><p>Translational science is the field that generates scientific and operational innovations that overcome the long-standing barriers along the translational research pipeline. By advancing translational science, we can improve the process of turning research observations into health solutions and ultimately bring more treatments to all people more quickly. Explore these resources to learn more about translational science.</p><div class="card"><div class="row"><div class="col-xl-2 col-lg-4 col-xm-12 col-12 text-center"><img class="img-fluid" src="/sites/default/files/2023-10/NCATS_Translational_Science_Infographic.jpg" width="1600" height="3166"></div><div class="col-xl-9 col-lg-8 col-xm-12 col-12"><h3>Translational Science Infographic</h3><p id="drug-development-illustrated">Developing new treatments can take a very long time. This infographic highlights some of the challenges as well as translational science approaches we’re using to overcome them.</p><div class="card-footer bg-white border-0 px-0"><a class href="#ts-infographic-modal" aria-controls="ts-infographic-modal" data-open-modal>View the Infographic</a></div><div class="usa-modal" id="ts-infographic-modal" aria-labelledby="modal-1-heading" aria-describedby="modal-1-description"><div class="usa-modal__content"><div class="usa-modal__main" style="padding:0 2rem 2rem;"><h2 class="usa-modal__heading" id="modal-1-heading">Translational Science Infographic</h2><img style="max-width:450px;" src="/sites/default/files/2023-10/NCATS_Translational_Science_Infographic.jpg" alt="Infographic about more treatments, more quickly. 95% of rare diseases have no approved treatments. And, no treatments take too long to develop." width="100%" height="100%"><div class="usa-modal__footer"><ul class="usa-button-group"><li class="usa-button-group__item"><button class="usa-button--unstyled padding-105 text-center" style="font-size:18px;" type="button" data-close-modal>Close</button></li></ul></div></div></div></div></div></div></div>
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<p>The Drug Discovery, Development and Deployment Maps (4DM) represent the modern therapeutic development process to more easily identify opportunities to expedite it. The maps provide a common framework for discussing the therapeutic development process and serve as an education tool for those who are new to it. They also can facilitate discussions on innovative solutions to existing bottlenecks.</p><p>Two versions of the 4DM are available: one for small molecules (Figure A), and another for biologics, using monoclonal antibodies as the representative therapeutic (Figure B). They illustrate some of the unique differences between the development of these products. Both files are licensed to the public under the Creative Commons Attribution-Share Alike International 4.0 (CC BY-SA 4.0) license, which allows use and adaption as long as the user provides attribution and shares any adaptations back to the public under the same license. <a href="https://pubmed.ncbi.nlm.nih.gov/29269942/">Read more about the 4DM</a>.</p><div class="grid-row grid-gap" style="margin-top:2rem;"><div class="desktop:grid-col-2"><div class="image-box"><a href="/sites/default/files/Figure%20A%20-%204DM%20Small%20Molecules%20Map.jpg" target="_blank"><img class="img-responsive" src="/sites/default/files/2023-10/small-molecule-4d-map-thumbnail_200x160_0.png" alt="Small 4D Molecule Map" width="NaN" height="NaN"></a><div class="caption-text"><p>Figure A: Small molecules</p></div></div></div><div class="desktop:grid-col-2"><div class="image-box"><a href="/sites/default/files/Figure%20B%20-%204DM%20Biologics%20Map.jpg" target="_blank"><img class="img-responsive" src="/sites/default/files/2023-10/biologics-4d-map-thumbnail_200x160.png" alt="Biologics 4D Molecule Map" width="NaN" height="NaN"></a><div class="caption-text"><p>Figure B: Biologics</p></div></div></div></div>
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<p><iframe width="560" height="315" src="https://www.youtube.com/embed/TnHLo-hCssg?si=SnjNyU0U01ZvSZa6" title="YouTube video player" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen></iframe></p><p>There is tremendous need for people to discover, develop and disseminate the next generation of science and technology to improve human health. Watch the video above to learn more about translational scientists.</p>
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<p>Translational scientists are innovative and collaborative, searching for ways to break down barriers in the translation process.</p><p><a href="https://pubs.acs.org/doi/10.1021/acsptsci.9b00022">Learn more about being a translational scientist</a>.</p>
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