556 lines
36 KiB
Text
556 lines
36 KiB
Text
<!DOCTYPE html>
|
||
<html lang="en" dir="ltr" prefix="og: https://ogp.me/ns#">
|
||
<head>
|
||
<meta charset="utf-8" />
|
||
<meta name="description" content="James Inglese, Ph.D., directs the Assay Development and Screening Technology laboratory within NCATS' Division of Preclinical Innovation." />
|
||
<meta name="abstract" content="James Inglese, Ph.D., directs the Assay Development and Screening Technology laboratory within NCATS' Division of Preclinical Innovation." />
|
||
<meta name="keywords" content="james inglese, ph.d., principal investigator, assay development and screening technology laboratory, division of preclinical innovation, national center for advancing translational sciences" />
|
||
<link rel="canonical" href="http://ncats.nih.gov/about/our-staff/jinglese" />
|
||
<meta name="google" content="PROqkJCbtNawPO29xzL4ENjcb0_EckySw96i97QXx8s" />
|
||
<meta name="google-site-verification" content="PROqkJCbtNawPO29xzL4ENjcb0_EckySw96i97QXx8s" />
|
||
<meta name="Generator" content="Drupal 10 (https://www.drupal.org)" />
|
||
<meta name="MobileOptimized" content="width" />
|
||
<meta name="HandheldFriendly" content="true" />
|
||
<meta name="viewport" content="width=device-width, initial-scale=1.0" />
|
||
<link rel="icon" href="/themes/custom/d9_subtheme/assets/images/favicon.ico" type="image/vnd.microsoft.icon" />
|
||
|
||
<title>Staff Profile: James Inglese</title>
|
||
<link rel="stylesheet" media="all" href="/libraries/drupal-superfish/css/superfish.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/ajax-progress.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/align.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/autocomplete-loading.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/fieldgroup.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/container-inline.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/clearfix.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/details.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/hidden.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/item-list.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/js.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/nowrap.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/position-container.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/progress.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/reset-appearance.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/resize.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/sticky-header.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/system-status-counter.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/system-status-report-counters.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/system-status-report-general-info.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/tabledrag.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/tablesort.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/tree-child.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/modules/contrib/extlink/extlink.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/layout_discovery/layouts/onecol/onecol.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="https://unpkg.com/aos@2.3.4/dist/aos.css" />
|
||
<link rel="stylesheet" media="all" href="https://cdn.jsdelivr.net/npm/@uswds/uswds@3.3.0/dist/css/uswds.min.css" />
|
||
<link rel="stylesheet" media="all" href="https://cdn.jsdelivr.net/npm/bootstrap@5.0.2/dist/css/bootstrap.min.css" />
|
||
<link rel="stylesheet" media="all" href="https://cdn.jsdelivr.net/npm/bootstrap-icons@1.11.1/font/bootstrap-icons.css" />
|
||
<link rel="stylesheet" media="all" href="/themes/custom/d9_subtheme/css/styles.css?srmo5o" />
|
||
|
||
<script src="https://dap.digitalgov.gov/Universal-Federated-Analytics-Min.js?agency=HHS&subagency=NIH" id="_fed_an_ua_tag" async type="text/javascript"></script>
|
||
|
||
</head>
|
||
<body class="path-node page-node-type-staff">
|
||
<a href="#main-content" class="usa-sr-only focusable">
|
||
Skip to main content
|
||
</a>
|
||
<noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-55CGV66V"
|
||
height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>
|
||
|
||
<div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas>
|
||
|
||
<section class="navigation-top">
|
||
<div class="container">
|
||
<div class="row">
|
||
<div class="col-12">
|
||
<div class="link-small d-flex">
|
||
|
||
<a href="http://www.hhs.gov/" title="Go to the hhs.gov" class="" target="_blank">
|
||
<img src="/sites/default/files/2023-10/hhs-white.png" alt="HHS Logo">
|
||
<span class="d-xl-inline d-lg-inline d-none small">U.S. Department of Health & Human Services</span>
|
||
</a>
|
||
|
||
<a href="http://www.nih.gov/" title="National Institutes of Health | Homepage" class="" target="_blank">
|
||
<img src="/sites/default/files/2023-10/nih-logo.png" alt="NIH Logo">
|
||
<span class="d-xl-inline d-lg-inline d-none small">National Institutes of Health</span>
|
||
</a>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
|
||
|
||
<div class="usa-overlay"></div>
|
||
|
||
<header class="usa-header usa-header--extended usa-header--extended-megamenu" id="header" role="banner">
|
||
|
||
|
||
|
||
|
||
|
||
<div class="region region-header grid-container">
|
||
<div class="grid-row grid-gap-1"><div class="desktop:grid-col-3 header-first">
|
||
<div class="usa-logo site-logo" id="logo">
|
||
|
||
<em class="usa-logo__text">
|
||
<a class="logo-img" href="/" accesskey="1" title="Home" aria-label="Home">
|
||
<img src="/themes/custom/d9_subtheme/logo.png" alt="Home" />
|
||
</a>
|
||
|
||
|
||
</em>
|
||
|
||
</div>
|
||
<div class="search-icon d-md-none"><a class="toggle-search" href="#"><i class="bi bi-search"></i></a></div>
|
||
|
||
</div><div class="desktop:grid-col-7">
|
||
<div id="block-navigation" class="block block-superfish block-superfishnavigation">
|
||
|
||
|
||
|
||
<ul id="superfish-navigation" class="menu sf-menu sf-navigation sf-horizontal sf-style-none">
|
||
|
||
<li id="navigation-menu-link-contentaed842ec-f581-4cea-b0b0-4a85c50def86" class="sf-depth-1 menuparent"><a href="/research" class="sf-depth-1 menuparent">Research</a><ul><li id="navigation-menu-link-content5a3b6aac-7ae9-45d7-929f-fbf776db20f0" class="sf-depth-2 sf-no-children"><a href="/research/overview" class="sf-depth-2">Research Overview</a></li><li id="navigation-menu-link-contentd0507d8b-7b88-453c-908a-2b7e961c0479" class="sf-depth-2 sf-no-children"><a href="/research/our-impact" class="sf-depth-2">Our Impact</a></li><li id="navigation-menu-link-contented530d1e-2ec3-46db-a529-9029be3f3fb4" class="sf-depth-2 sf-no-children"><a href="/research/research-activities" class="sf-depth-2">Research Activities</a></li><li id="navigation-menu-link-content2dac8545-38f2-47c0-8993-ea0cae65e123" class="sf-depth-2 sf-no-children"><a href="/research/research-resources" class="sf-depth-2">Research Resources</a></li><li id="navigation-menu-link-content311ec98e-6232-4e22-9966-4a9ac796870a" class="sf-depth-2 sf-no-children"><a href="/research/training-education" class="sf-depth-2">Training & Education</a></li><li id="navigation-menu-link-content52b1ba41-94ea-4d84-9db7-7482b8f78f16" class="sf-depth-2 sf-no-children"><a href="/research/alliances" class="sf-depth-2">Alliances</a></li><li id="navigation-menu-link-contenta185af75-90a5-4cc4-813f-ef66f35e21ea" class="sf-depth-2 sf-no-children"><a href="/research/collaborate-with-ncats" class="sf-depth-2">Collaborate With NCATS</a></li></ul></li><li id="navigation-menu-link-content84a3cc1f-203d-4de6-ab26-d80c256b96dc" class="sf-depth-1 menuparent"><a href="/funding" class="sf-depth-1 menuparent">Funding</a><ul><li id="navigation-menu-link-content0a09bed2-3d99-4faf-b3c5-fc9a4878629a" class="sf-depth-2 sf-no-children"><a href="/funding/overview" class="sf-depth-2">Funding Overview</a></li><li id="navigation-menu-link-contentd85a1f38-7893-4e4a-8514-5b9e767983e2" class="sf-depth-2 sf-no-children"><a href="/funding/funding-opportunities" class="sf-depth-2">Open Funding Opportunities</a></li><li id="navigation-menu-link-content81e84c00-ef73-4aff-a15f-7728cc398801" class="sf-depth-2 sf-no-children"><a href="/funding/small-business-programs" class="sf-depth-2">Small Business Programs</a></li><li id="navigation-menu-link-content631a166b-650b-450f-97b4-9014d14935e9" class="sf-depth-2 sf-no-children"><a href="/funding/funding-policy-operating-guidelines" class="sf-depth-2">Funding Policy & Operating Guidelines</a></li><li id="navigation-menu-link-content5d56ebe7-b3e8-452a-bd30-df92b0deabef" class="sf-depth-2 sf-no-children"><a href="/funding/grant-information" class="sf-depth-2">Grant Information</a></li><li id="navigation-menu-link-content4429fdc9-e911-4022-b3dc-3f6a4980b9ff" class="sf-depth-2 sf-no-children"><a href="/funding/challenges" class="sf-depth-2">Challenges and Prize Competitions</a></li><li id="navigation-menu-link-content943fe682-94ff-4fcf-a6b0-32096d2b2d0e" class="sf-depth-2 sf-no-children"><a href="/funding/scientific-review" class="sf-depth-2">Scientific Review</a></li><li id="navigation-menu-link-content10496705-320e-4437-b2ba-ea2830b293d1" class="sf-depth-2 sf-no-children"><a href="/funding/conference-grant-information" class="sf-depth-2">Conference Grant Information</a></li></ul></li><li id="navigation-menu-link-contentea91f2ef-1b8d-4b1c-83e7-5830769dd505" class="sf-depth-1 menuparent"><a href="/resources" class="sf-depth-1 menuparent">Resources For You</a><ul><li id="navigation-menu-link-content567e64e3-685d-41bc-8bf4-130c7689d6a2" class="sf-depth-2 sf-no-children"><a href="/resources/overview" title="Resources for You" class="sf-depth-2">Resources for You</a></li><li id="navigation-menu-link-content786ce1f5-ff7a-463a-bb05-c01882062426" class="sf-depth-2 sf-no-children"><a href="/resources/for-researchers" title="Resources for Researchers" class="sf-depth-2">Resources for Researchers</a></li><li id="navigation-menu-link-contente737ec67-ecd0-4f18-915d-b61660cb524f" class="sf-depth-2 sf-no-children"><a href="/resources/for-trainees" title="Resources for Trainees" class="sf-depth-2">Resources for Trainees</a></li><li id="navigation-menu-link-content8812fdb6-0fb7-4b27-8401-2fc5b3f41ff1" class="sf-depth-2 sf-no-children"><a href="/resources/for-rare-disease-patients-and-advocates" title="Resources for Rare Disease Patients and Advocates" class="sf-depth-2">Resources for Rare Disease Patients and Advocates</a></li></ul></li><li id="navigation-menu-link-contenta8527040-df23-4117-a5a7-566bd83e2c7f" class="sf-depth-1 menuparent"><a href="/news-events" class="sf-depth-1 menuparent">News & Events</a><ul><li id="navigation-menu-link-contentf6836a81-a42a-4528-b569-18939d8451da" class="sf-depth-2 sf-no-children"><a href="/news-events/overview" class="sf-depth-2">News & Events Overview</a></li><li id="navigation-menu-link-content9f44edc6-e5b7-4a92-bcb3-c0a8777461f4" class="sf-depth-2 sf-no-children"><a href="/news-events/news" class="sf-depth-2">News</a></li><li id="navigation-menu-link-content402cff9f-12b7-459b-9f0f-56606930399c" class="sf-depth-2 sf-no-children"><a href="/news-events/newsletter" class="sf-depth-2">Newsletters</a></li><li id="navigation-menu-link-content6cd76cbe-053e-4e3b-8961-c9f5def57ba6" class="sf-depth-2 sf-no-children"><a href="/news-events/events" class="sf-depth-2">Events</a></li><li id="navigation-menu-link-content0a211675-2fb5-45cc-b443-c7946e7d9120" class="sf-depth-2 sf-no-children"><a href="/news-events/science-publications" class="sf-depth-2">Scientific Publications</a></li><li id="navigation-menu-link-contente6d4ed4f-826f-41b4-a9e2-728c2fb4ca62" class="sf-depth-2 sf-no-children"><a href="/news-events/multimedia" class="sf-depth-2">Multimedia</a></li></ul></li><li id="navigation-menu-link-contentf1eb1fa8-5813-433c-9bcc-dc56f2e258f3" class="sf-depth-1 menuparent"><a href="/about" class="sf-depth-1 menuparent">About NCATS</a><ul><li id="navigation-menu-link-contentada9a195-ae5a-446a-9014-c1232164e6db" class="sf-depth-2 sf-no-children"><a href="/about/ncats-overview" class="sf-depth-2">NCATS Overview</a></li><li id="navigation-menu-link-contentd5e0369a-aded-4348-84f7-463c64498447" class="sf-depth-2 sf-no-children"><a href="/about/about-translational-science" class="sf-depth-2">About Translational Science</a></li><li id="navigation-menu-link-contente298b7b2-724e-408b-9bb9-afcaac57a751" class="sf-depth-2 sf-no-children"><a href="/about/advisory-committees" class="sf-depth-2">Advisory Committees</a></li><li id="navigation-menu-link-contentbc9c91b7-8d3d-4d2c-af65-c25ef894d269" class="sf-depth-2 sf-no-children"><a href="/about/budget" class="sf-depth-2">Budget</a></li><li id="navigation-menu-link-contenta4ed4439-05db-4a41-9357-731c2ff74543" class="sf-depth-2 sf-no-children"><a href="/about/director" class="sf-depth-2">Director's Corner</a></li><li id="navigation-menu-link-contentb50f96af-3723-4634-8566-4e60c2639491" class="sf-depth-2 sf-no-children"><a href="/about/divisions-and-offices" class="sf-depth-2">Divisions & Offices</a></li><li id="navigation-menu-link-content41d11ad4-c576-46be-a326-1f8cf5059354" class="sf-depth-2 sf-no-children"><a href="/about/our-staff" class="sf-depth-2">Our Staff</a></li></ul></li>
|
||
</ul>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="desktop:grid-col-2 search-block">
|
||
<form class="usa-search usa-search--small" action="/search/node" method="get" id="search-block-form" accept-charset="UTF-8">
|
||
<div role="search">
|
||
|
||
<input class="usa-input" id="extended-search-field-small" type="search" name="keys" />
|
||
<button class="usa-button" type="submit">
|
||
<img src="/themes/custom/d9_subtheme/node_modules/@uswds/uswds/dist/img/usa-icons-bg/search--white.svg" class="usa-search__submit-icon" alt="Search">
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div></div>
|
||
</div>
|
||
|
||
|
||
<nav class="usa-nav" role="navigation">
|
||
<div class="usa-nav__inner">
|
||
|
||
<button type="button" class="usa-nav__close">
|
||
<img src="/themes/custom/d9_subtheme/node_modules/@uswds/uswds/dist/img/usa-icons/close.svg" alt="close"/>
|
||
</button>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</nav>
|
||
|
||
|
||
</header>
|
||
|
||
<main class="main-content usa-layout-docs usa-section " role="main"
|
||
id="main-content">
|
||
|
||
<div class="grid-container-">
|
||
|
||
<div class="grid-row">
|
||
|
||
</div>
|
||
|
||
<div class="">
|
||
|
||
</div>
|
||
|
||
<div class="grid-row ">
|
||
|
||
</div>
|
||
|
||
<div class="grid-row grid-gap">
|
||
|
||
<div class="usa-layout-docs__main desktop:grid-col-fill">
|
||
<div class="">
|
||
<div data-drupal-messages-fallback class="hidden"></div>
|
||
<div id="block-d9-subtheme-content" class="block block-system block-system-main-block">
|
||
|
||
|
||
<article data-history-node-id="3636">
|
||
|
||
|
||
|
||
|
||
|
||
<div>
|
||
<div class="container">
|
||
<div class="row">
|
||
|
||
<div class="container region--top">
|
||
<div class="block block-system block-system-breadcrumb-block">
|
||
|
||
|
||
<nav class="usa-breadcrumb" role="navigation" aria-labelledby="system-breadcrumb">
|
||
<h2 id="system-breadcrumb" class="usa-sr-only">Breadcrumb</h2>
|
||
<ol class="usa-breadcrumb__list">
|
||
<li class="usa-breadcrumb__list-item">
|
||
<a href="/" class="usa-breadcrumb__link"><span>Home</span></a>
|
||
</li>
|
||
<li class="usa-breadcrumb__list-item">
|
||
<a href="/about/ncats-overview" class="usa-breadcrumb__link"><span>NCATS Overview</span></a>
|
||
</li>
|
||
<li class="usa-breadcrumb__list-item">
|
||
<a href="/about/our-staff" class="usa-breadcrumb__link"><span>Our Staff</span></a>
|
||
</li>
|
||
<li class="usa-breadcrumb__list-item">
|
||
<span>Staff Profile: James Inglese</span>
|
||
</li>
|
||
</ol>
|
||
</nav>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="container col-sm-9">
|
||
<div class="_none block block-layout-builder block-inline-blockbasic" data-aos-anchor-placement="top-bottom" data-aos-easing="ease">
|
||
|
||
|
||
|
||
|
||
<style>
|
||
h2,
|
||
h2.block-heading,
|
||
h3 {
|
||
font-size:36px;
|
||
font-family: "Oswald";
|
||
}
|
||
</style><p>
|
||
|
||
|
||
</p><div class="col">
|
||
<div class="row">
|
||
<div class="col-sm-12">
|
||
<h3>James Inglese, Ph.D.</h3>
|
||
<p class="mb-1"><strong>Principal Investigator</strong></p>
|
||
<p class="mb-1">
|
||
|
||
|
||
</p>
|
||
<p class="mb-1">Division of Preclinical Innovation </p>
|
||
<p class="mb-1"><strong></strong></p>
|
||
<p>Assay Development and Screening Technology Laboratory</p>
|
||
</div>
|
||
<div class="col-sm-12">
|
||
<p class="mb-1"><strong>Contact Info</strong></p>
|
||
<p><a href="mailto:jinglese@mail.nih.gov">jinglese@mail.nih.gov</a></p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="container col-sm-3">
|
||
<div class="block block-layout-builder block-field-blocknodestafffield-staff-image">
|
||
|
||
|
||
|
||
|
||
<img loading="lazy" src="/sites/default/files/styles/staff/public/staff/James-Inglese_900x1000px.jpg?itok=oxbJ-6va" width="200" height="222" alt="Portrait of James Inglese, Ph.D." />
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="container region--bottom">
|
||
<div class="block block-layout-builder block-field-blocknodestaffbody">
|
||
|
||
|
||
|
||
|
||
<h2>Biography</h2><p>James Inglese, Ph.D., directs the <a href="/research/research-activities/adst" title="Assay Development and Screening Technology (ADST) | National Center for Advancing Translational Sciences">Assay Development and Screening Technology</a> laboratory within NCATS' <a href="/about/divisions-and-offices#DPI">Division of Preclinical Innovation</a>. His postdoctoral training program has been recognized by disease foundations as an effective collaborative bridge to NCATS’ expertise and resources, enabling a champion-driven effort in early-stage translation. Prior to the formation of NCATS, in 2004 Inglese <a class="exit" href="http://www.sciencemag.org/content/304/5678/1728.1.long" title="Science Magazine: Sign In">co-founded the NIH Chemical Genomics Center</a> (now at NCATS), later acting as its deputy director.</p><p>Inglese received his Ph.D. in organic chemistry from Pennsylvania State University, under the guidance of chemist and enzymologist Stephen J. Benkovic, Ph.D., where Inglese studied tetrahydrofolate-dependent purine biosynthetic enzymes as new anticancer targets. He then acquired expertise in cellular and molecular biology through postdoctoral training in the laboratory of Nobel Laureate Robert J. Lefkowitz, M.D., at Duke University Medical Center, investigating regulatory kinases of G protein–coupled receptor signaling. Before coming to NIH, Inglese led research teams at the Princeton-based combinatorial chemistry biotechnology company Pharmacopeia, Inc., and at Merck Research Laboratories.</p><p>Inglese has contributed to <a href="https://scholar.google.com/citations?user=Oz984NYAAAAJ&hl=en&oi=ao" target="_blank" title="Scientific publications by James Inglese, listed in Google Scholar">more than 180 publications</a> and patents and is the founding editor of the journal <em>ASSAY and Drug Development Technologies</em>, serving as editor-in-chief from 2002 to 2014. He co-chaired the 2015 conference of the Society of Laboratory Automation and Screening. Inglese also serves as a scientific advisor to NIH-funded chemistry and screening centers, disease foundations, and international chemical biology consortia.</p><h2>Research Topics</h2><p>Inglese’s laboratory investigates strategies to identify chemical modulators targeting the molecular underpinnings of disease pathophysiology. His laboratory specializes in the design and reduction to practice of biochemical and cell-based assays for quantitative high-throughput screening (qHTS). Biological processes, including gene expression, posttranslational regulation, signaling and metabolism, that are involved in disorders ranging from infections to neuropathies have formed the basis of assays developed in his laboratory. The assays have been used to interrogate collections of clinically approved drugs to those composed of diverse novel substances, such as those found in microbial natural product extracts.</p><p>To advance a more efficient drug discovery model, Inglese’s laboratory conducts research in high-throughput techniques, assay technologies and analysis methods for large-scale qHTS data. For example, by integrating a <a href="/pubs/features/identify-drug-candidates" title="A New Method to Help Scientists Better Identify Drug Candidates | National Center for Advancing Translational Sciences">reporter gene system</a> created in his laboratory to reduce the incidence of false-positives with advances made in the genome editing field, he and his colleagues engineered novel cell line models of specific disease phenotypes, enabling high-fidelity testing of very large chemical libraries.</p>
|
||
|
||
</div>
|
||
<div class="_none block block-layout-builder block-field-blocknodestafffield-non-ncats-publications" data-aos-anchor-placement="top-bottom" data-aos-easing="ease">
|
||
|
||
<h2 class="block-heading">Selected Publications</h2>
|
||
|
||
|
||
|
||
<ol>
|
||
<li>
|
||
|
||
<h6 class="title"><a data-type="External" href="https://www.nature.com/articles/ncomms14932">Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases.</a></h6></li>
|
||
<li>
|
||
|
||
<h6 class="title"><a data-type="External" href="https://pubmed.ncbi.nlm.nih.gov/26465675/">Actinoramide A Identified as a Potent Antimalarial from Titration-Based Screening of Marine Natural Product Extracts.</a></h6></li>
|
||
<li>
|
||
|
||
<h6 class="title"><a data-type="External" href="https://pubmed.ncbi.nlm.nih.gov/25689131/">Chemogenomic profiling of endogenous PARK2 expression using a genome-edited coincidence reporter.</a></h6></li>
|
||
<li>
|
||
|
||
<h6 class="title"><a data-type="External" href="https://pubmed.ncbi.nlm.nih.gov/17637779/">High-throughput screening assays for the identification of chemical probes.</a></h6></li>
|
||
<li>
|
||
|
||
<h6 class="title"><a data-type="External" href="https://pubmed.ncbi.nlm.nih.gov/16864780/">Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.</a></h6></li>
|
||
</ol>
|
||
|
||
|
||
</div>
|
||
<div class="_none block block-layout-builder block-inline-blockbasic" data-aos-anchor-placement="top-bottom" data-aos-easing="ease">
|
||
|
||
|
||
|
||
|
||
<script type="text/javascript">
|
||
document.querySelectorAll('.col').forEach(function(node) {
|
||
node.innerHTML = node.innerHTML.replace(/&amp;/g, '&');
|
||
});
|
||
</script>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div> <div class="container layout layout--onecol">
|
||
<div class="layout__region layout__region--content">
|
||
<div class="block block-layout-builder block-field-blocknodestafffield-related-research">
|
||
|
||
<h2 class="block-heading">Related Research</h2>
|
||
|
||
|
||
|
||
<div class="row col">
|
||
<div class="col-sm-4 mb-4 views-row"><div class="usa-card__container">
|
||
<div class="usa-card__body">
|
||
|
||
<h6 class="title">Assay Development and Screening Technology (ADST)</h6>
|
||
|
||
|
||
<p>Our scientists explore and develop new ways to quickly test and screen potential drug candidates, often in collaboration with disease foundations.</p>
|
||
|
||
</div>
|
||
<div class="usa-card__footer">
|
||
<a href="/research/research-activities/ADST">Learn More</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</article>
|
||
|
||
</div>
|
||
<div id="block-footercss" class="block block-block-content block-block-content2db33373-6fb7-49c5-be2f-83266eddea39">
|
||
|
||
|
||
|
||
|
||
<style type="text/css">
|
||
ul#superfish-navigation li { line-height:1.25; }
|
||
.region-header .block-superfish ul.sf-menu li a {padding-right:40px !important;}
|
||
@media (min-width: 1200px) {
|
||
ul.sf-menu.sf-navigation li.menuparent ul {width:280px !important;}
|
||
}
|
||
.main-content article .menu--navigation {
|
||
display:flex;
|
||
flex-wrap: nowrap;
|
||
justify-content: space-between;
|
||
align-items: stretch;
|
||
}
|
||
.main-content article .menu--navigation li {
|
||
flex: 1 1 0;
|
||
width: 0;
|
||
align-items: center;
|
||
display: flex;
|
||
justify-content: center;
|
||
}
|
||
.main-content article .menu--navigation li .dropdown-toggle {
|
||
white-space: unset;
|
||
}
|
||
.image-box img,
|
||
div.col-md-4.col-lg-2 img {
|
||
height: auto;
|
||
}
|
||
.caption-left-md {
|
||
float: left;
|
||
width: 50%;
|
||
margin: 0 1% 2% 0;
|
||
border: 1px solid #ddd;
|
||
}
|
||
.caption-left-md img {
|
||
width: 100%!important;
|
||
height: auto;
|
||
}
|
||
div.block.block-layout-builder.block-field-blocknodestafffield-divisions-office {
|
||
display: none
|
||
}
|
||
@media (max-width: 992px) {
|
||
.main-content article .menu--navigation {
|
||
flex-direction:column;
|
||
}
|
||
.main-content article .menu--navigation li {
|
||
display:inline-block;
|
||
margin:0;
|
||
padding:.25rem;
|
||
width: auto;
|
||
text-align:left;
|
||
}
|
||
.main-content article .menu--navigation li:hover, .main-content article .menu--navigation li.active {
|
||
border-bottom: 4px solid transparent !important;
|
||
}
|
||
.main-content article .menu--navigation li:hover a, .main-content article .menu--navigation li.active a {
|
||
border-bottom:4px solid #00626f !important;
|
||
padding-bottom:4px;
|
||
}
|
||
}
|
||
p.last-update-container {
|
||
font-size: 15px;
|
||
font-style: italic;
|
||
}
|
||
</style>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</main>
|
||
<div>
|
||
<div id="block-d9-subtheme-lastupdateblock" class="block block-ncats-common block-last-update-block">
|
||
|
||
|
||
<div class="container"><p class="last-update-container">Last updated on April 18, 2024</p></div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<footer class="pt-4 footer mt-4">
|
||
<div class="container">
|
||
<div class="row">
|
||
<div class="col-12 py-4">
|
||
<img src="/sites/default/files/2023-10/ncats-logo-footer.png" class="img-fluid" alt="NCATS">
|
||
</div>
|
||
</div>
|
||
|
||
<div class="row">
|
||
<div class="container">
|
||
<div class="row justify-content-between">
|
||
<div class="col-xl-4">
|
||
<div class="pt-4">
|
||
<address>
|
||
9609 Medical Center Drive<br>
|
||
Rockville, MD 20850-9793<br>
|
||
301-594-8966<br>
|
||
<a href="mailto:ncatsinfo@nih.gov">ncatsinfo@nih.gov</a>
|
||
</address>
|
||
</div>
|
||
|
||
<div class="text-white social-links mt-4">
|
||
<h5>Connect with us</h5>
|
||
<ul id="social-media-icons" class="list-unstyled d-flex mb-4">
|
||
<li><a href="http://www.facebook.com/ncats.nih.gov" title="Visit us on Facebook" target="_blank"><i class="bi bi-facebook"></i></a></li>
|
||
<li><a href="https://www.linkedin.com/company/nih-ncats" title="Visit us on LinkedIn" target="_blank"><i class="bi bi-linkedin"></i></a></li>
|
||
<li><a href="http://www.twitter.com/ncats_nih_gov" title="Visit us on X" target="_blank"><i class="bi bi-twitter-x"></i></a></li>
|
||
<li><a href="http://www.youtube.com/user/ncatsmedia" title="View our videos on YouTube" target="_blank"><i class="bi bi-youtube"></i></a></li>
|
||
<li><a href="https://www.flickr.com/photos/64860478@N05/" target="_blank" title="View our photos on Flickr"><img src="/sites/default/files/2023-10/flickr.png" alt="View our photos on Flickr" style="height:24px;"></a></li>
|
||
</ul>
|
||
<p class="small">For <a href="http://edi.nih.gov/consulting/language-access-program/about" target="_blank">language access assistance</a>, contact the <a href="mailto:ncatsinfo@nih.gov">NCATS Public Information Officer</a></p>
|
||
</div>
|
||
|
||
</div>
|
||
<div class="col-xl-3 text-white mt-5 d-lg-none d-sm-none d-none d-xl-block">
|
||
<div id="mc_embed_shell">
|
||
|
||
<div id="mc_embed_signup">
|
||
<form action="https://nih.us5.list-manage.com/subscribe/post?u=e06bd55ccbb41f1a362306dff&id=d32fa404b4&f_id=0087b1edf0" method="post" id="mc-embedded-subscribe-form" name="mc-embedded-subscribe-form" class="validate" target="_blank">
|
||
<h5>Subscribe to NCATS News</h5>
|
||
<p>If you would like to stay up to date with the latest information from us, please sign up for NCATS News.</p>
|
||
<div id="mce-responses" class="clear">
|
||
<div class="response" id="mce-error-response" style="display: none;"></div>
|
||
<div class="response" id="mce-success-response" style="display: none;"></div>
|
||
</div>
|
||
<div class="input-group mb-3">
|
||
<input type="email" name="EMAIL" class="required email form-control" id="mce-EMAIL" required="" value="" placeholder="Enter Email" aria-label="Recipient's username" aria-describedby="button-addon2" tabindex="-1">
|
||
|
||
<div aria-hidden="true" style="position: absolute; left: -5000px;"><input type="text" name="b_e06bd55ccbb41f1a362306dff_d32fa404b4" tabindex="-1" value=""></div>
|
||
<button type="submit" name="subscribe" id="mc-embedded-subscribe" class="button btn" value="Subscribe">Submit</button>
|
||
</div>
|
||
|
||
</form>
|
||
</div>
|
||
<script type="text/javascript" src="//s3.amazonaws.com/downloads.mailchimp.com/js/mc-validate.js"></script><script type="text/javascript">(function($) {window.fnames = new Array(); window.ftypes = new Array();fnames[0]='EMAIL';ftypes[0]='email';fnames[1]='FNAME';ftypes[1]='text';fnames[2]='LNAME';ftypes[2]='text';fnames[3]='SIGNUP';ftypes[3]='text';}(jQuery));var $mcj = jQuery.noConflict(true);</script></div>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
<!-- footer menu section -->
|
||
|
||
<section class="footer-menu py-3 mb-xl-0 mb-lg-0 mb-sm-5 mt-4">
|
||
<div class="container">
|
||
<div class="row">
|
||
<div class="col-12">
|
||
<ul class="list-unstyled d-xl-flex d-lg-flex d-sm-block d-block justify-content-center mb-0">
|
||
<li><a href="https://ncats.nih.gov/">NCATS Home</a></li>
|
||
<li><a href="/sitemap">Site Map</a></li>
|
||
<li><a href="/privacy">Privacy Notice</a></li>
|
||
<li><a href="/comments">Comment Policy</a></li>
|
||
<li><a href="/accessibility">Accessibility</a></li>
|
||
<li><a href="/foia">FOIA</a></li>
|
||
<li><a href="http://oig.hhs.gov/" target="_blank">OIG</a></li>
|
||
<li class="border-0"><a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" target="_blank">HHS Vulnerability Disclosure</a></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
</footer>
|
||
|
||
</div>
|
||
|
||
|
||
<script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","pathPrefix":"","currentPath":"node\/3636","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"en"},"pluralDelimiter":"\u0003","suppressDeprecationErrors":true,"ajaxPageState":{"libraries":"eJx1j1FuxCAMRC9Ew3dPgxwwxF2DI2y6m9uXSG21W6U_o5k3GslO70HHahtW9KCKpi49IXwY9gb8BlMOo6huIqZ286mPHXj5jq6IFMZgUHyZ8jcv8AGPV1gdwyHDQiKN8on98NIwCjsdO_ZMuvlfd8XCdq6oGTa77LUCs8aO2K77081f9b92FyUjmetDDatfQdENvScNp_W5Q8W79NsP5DVEaZnK6HAO_c6jUFvmEcIcMGeMpss6iNMXOEOXGQ","theme":"d9_subtheme","theme_token":null},"ajaxTrustedUrl":[],"gtm":{"tagId":null,"settings":{"data_layer":"dataLayer","include_classes":false,"allowlist_classes":"","blocklist_classes":"","include_environment":false,"environment_id":"","environment_token":""},"tagIds":["GTM-55CGV66V"]},"gtag":{"tagId":"G-ZZQ8H5G8ZX","otherIds":[],"events":[],"additionalConfigInfo":[]},"data":{"extlink":{"extTarget":true,"extTargetNoOverride":false,"extNofollow":false,"extNoreferrer":true,"extFollowNoOverride":false,"extClass":"ext","extLabel":"(link is external)","extImgClass":false,"extSubdomains":true,"extExclude":"","extInclude":"","extCssExclude":"","extCssExplicit":"","extAlert":true,"extAlertText":"You are leaving the NIH website.\r\n\r\nThis external link provides additional information that is consistent with the intended purpose of this site. NIH cannot attest to the accuracy of a non-federal site.\r\n\r\nLinking to a non-federal site does not constitute an endorsement by NIH or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site\u0027s privacy policy when you follow the link.","mailtoClass":"mailto","mailtoLabel":"(link sends email)","extUseFontAwesome":false,"extIconPlacement":"append","extFaLinkClasses":"fa fa-external-link","extFaMailtoClasses":"fa fa-envelope-o","whitelistedDomains":[]}},"superfish":{"superfish-navigation":{"id":"superfish-navigation","sf":{"animation":{"opacity":"show","height":"show"},"speed":"fast"},"plugins":{"smallscreen":{"mode":"window_width","accordionButton":0,"title":"Navigation"},"supposition":true,"supersubs":true}}},"user":{"uid":0,"permissionsHash":"24b2a698a72e7a44d4f2d94d9880a6ba82bfbc8b8200dee23422144335254cbc"}}</script>
|
||
<script src="/core/assets/vendor/jquery/jquery.min.js?v=3.7.1"></script>
|
||
<script src="/core/assets/vendor/once/once.min.js?v=1.0.1"></script>
|
||
<script src="/core/misc/drupalSettingsLoader.js?v=10.2.3"></script>
|
||
<script src="/core/misc/drupal.js?v=10.2.3"></script>
|
||
<script src="/core/misc/drupal.init.js?v=10.2.3"></script>
|
||
<script src="https://unpkg.com/aos@2.3.4/dist/aos.js"></script>
|
||
<script src="/core/assets/vendor/tabbable/index.umd.min.js?v=6.2.0"></script>
|
||
<script src="https://cdn.jsdelivr.net/npm/@uswds/uswds@3.3.0/dist/js/uswds.min.js"></script>
|
||
<script src="/core/misc/progress.js?v=10.2.3"></script>
|
||
<script src="/core/assets/vendor/loadjs/loadjs.min.js?v=4.2.0"></script>
|
||
<script src="/core/misc/debounce.js?v=10.2.3"></script>
|
||
<script src="/core/misc/announce.js?v=10.2.3"></script>
|
||
<script src="/core/misc/message.js?v=10.2.3"></script>
|
||
<script src="/core/misc/ajax.js?v=10.2.3"></script>
|
||
<script src="/themes/custom/d9_subtheme/js/script.js?v=10.2.3"></script>
|
||
<script src="/modules/contrib/extlink/extlink.js?v=10.2.3"></script>
|
||
<script src="/modules/contrib/google_tag/js/gtm.js?srmo5o"></script>
|
||
<script src="/modules/contrib/google_tag/js/gtag.js?srmo5o"></script>
|
||
<script src="/modules/contrib/google_tag/js/gtag.ajax.js?srmo5o"></script>
|
||
<script src="/modules/contrib/uswds_blb_configuration/js/plugins/scroll_effects/build.js?v=1.x"></script>
|
||
<script src="/libraries/drupal-superfish/superfish.js?srmo5o"></script>
|
||
<script src="/libraries/drupal-superfish/jquery.hoverIntent.minified.js?srmo5o"></script>
|
||
<script src="/libraries/drupal-superfish/sfsmallscreen.js?srmo5o"></script>
|
||
<script src="/libraries/drupal-superfish/supposition.js?srmo5o"></script>
|
||
<script src="/libraries/drupal-superfish/supersubs.js?srmo5o"></script>
|
||
<script src="/modules/contrib/superfish/js/superfish.js?v=2.0"></script>
|
||
|
||
</body>
|
||
</html>
|