509 lines
35 KiB
Text
509 lines
35 KiB
Text
<!DOCTYPE html>
|
||
<html lang="en" dir="ltr" prefix="og: https://ogp.me/ns#">
|
||
<head>
|
||
<meta charset="utf-8" />
|
||
<meta name="description" content="We have assembled high-value, modern chemical libraries to advance translational science." />
|
||
<meta name="keywords" content="Chemical Libraries, Genesis, NPACT, translational sciences, NCATS" />
|
||
<link rel="canonical" href="http://ncats.nih.gov/research/research-activities/compound-management/chemical-libraries" />
|
||
<meta name="google" content="PROqkJCbtNawPO29xzL4ENjcb0_EckySw96i97QXx8s" />
|
||
<meta name="google-site-verification" content="PROqkJCbtNawPO29xzL4ENjcb0_EckySw96i97QXx8s" />
|
||
<meta name="Generator" content="Drupal 10 (https://www.drupal.org)" />
|
||
<meta name="MobileOptimized" content="width" />
|
||
<meta name="HandheldFriendly" content="true" />
|
||
<meta name="viewport" content="width=device-width, initial-scale=1.0" />
|
||
<link rel="icon" href="/themes/custom/d9_subtheme/assets/images/favicon.ico" type="image/vnd.microsoft.icon" />
|
||
|
||
<title>Chemical Libraries: Genesis and NPACT | National Center for Advancing Translational Sciences</title>
|
||
<link rel="stylesheet" media="all" href="/libraries/drupal-superfish/css/superfish.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/ajax-progress.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/align.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/autocomplete-loading.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/fieldgroup.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/container-inline.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/clearfix.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/details.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/hidden.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/item-list.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/js.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/nowrap.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/position-container.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/progress.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/reset-appearance.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/resize.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/sticky-header.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/system-status-counter.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/system-status-report-counters.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/system-status-report-general-info.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/tabledrag.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/tablesort.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/tree-child.module.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/modules/contrib/extlink/extlink.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/core/modules/layout_discovery/layouts/onecol/onecol.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="/modules/contrib/paragraphs/css/paragraphs.unpublished.css?srmo5o" />
|
||
<link rel="stylesheet" media="all" href="https://cdn.jsdelivr.net/npm/@uswds/uswds@3.3.0/dist/css/uswds.min.css" />
|
||
<link rel="stylesheet" media="all" href="https://cdn.jsdelivr.net/npm/bootstrap@5.0.2/dist/css/bootstrap.min.css" />
|
||
<link rel="stylesheet" media="all" href="https://cdn.jsdelivr.net/npm/bootstrap-icons@1.11.1/font/bootstrap-icons.css" />
|
||
<link rel="stylesheet" media="all" href="/themes/custom/d9_subtheme/css/styles.css?srmo5o" />
|
||
|
||
<script src="https://dap.digitalgov.gov/Universal-Federated-Analytics-Min.js?agency=HHS&subagency=NIH" id="_fed_an_ua_tag" async type="text/javascript"></script>
|
||
|
||
</head>
|
||
<body class="path-node page-node-type-landing-page-new-">
|
||
<a href="#main-content" class="usa-sr-only focusable">
|
||
Skip to main content
|
||
</a>
|
||
<noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-55CGV66V"
|
||
height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>
|
||
|
||
<div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas>
|
||
|
||
<section class="navigation-top">
|
||
<div class="container">
|
||
<div class="row">
|
||
<div class="col-12">
|
||
<div class="link-small d-flex">
|
||
|
||
<a href="http://www.hhs.gov/" title="Go to the hhs.gov" class="" target="_blank">
|
||
<img src="/sites/default/files/2023-10/hhs-white.png" alt="HHS Logo">
|
||
<span class="d-xl-inline d-lg-inline d-none small">U.S. Department of Health & Human Services</span>
|
||
</a>
|
||
|
||
<a href="http://www.nih.gov/" title="National Institutes of Health | Homepage" class="" target="_blank">
|
||
<img src="/sites/default/files/2023-10/nih-logo.png" alt="NIH Logo">
|
||
<span class="d-xl-inline d-lg-inline d-none small">National Institutes of Health</span>
|
||
</a>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
|
||
|
||
<div class="usa-overlay"></div>
|
||
|
||
<header class="usa-header usa-header--extended usa-header--extended-megamenu" id="header" role="banner">
|
||
|
||
|
||
|
||
|
||
|
||
<div class="region region-header grid-container">
|
||
<div class="grid-row grid-gap-1"><div class="desktop:grid-col-3 header-first">
|
||
<div class="usa-logo site-logo" id="logo">
|
||
|
||
<em class="usa-logo__text">
|
||
<a class="logo-img" href="/" accesskey="1" title="Home" aria-label="Home">
|
||
<img src="/themes/custom/d9_subtheme/logo.png" alt="Home" />
|
||
</a>
|
||
|
||
|
||
</em>
|
||
|
||
</div>
|
||
<div class="search-icon d-md-none"><a class="toggle-search" href="#"><i class="bi bi-search"></i></a></div>
|
||
|
||
</div><div class="desktop:grid-col-7">
|
||
<div id="block-navigation--2" class="block block-superfish block-superfishnavigation">
|
||
|
||
|
||
|
||
<ul id="superfish-navigation" class="menu sf-menu sf-navigation sf-horizontal sf-style-none">
|
||
|
||
<li id="navigation-menu-link-contentaed842ec-f581-4cea-b0b0-4a85c50def86" class="active-trail sf-depth-1 menuparent"><a href="/research" class="sf-depth-1 menuparent">Research</a><ul><li id="navigation-menu-link-content5a3b6aac-7ae9-45d7-929f-fbf776db20f0" class="sf-depth-2 sf-no-children"><a href="/research/overview" class="sf-depth-2">Research Overview</a></li><li id="navigation-menu-link-contentd0507d8b-7b88-453c-908a-2b7e961c0479" class="sf-depth-2 sf-no-children"><a href="/research/our-impact" class="sf-depth-2">Our Impact</a></li><li id="navigation-menu-link-contented530d1e-2ec3-46db-a529-9029be3f3fb4" class="active-trail sf-depth-2 sf-no-children"><a href="/research/research-activities" class="sf-depth-2">Research Activities</a></li><li id="navigation-menu-link-content2dac8545-38f2-47c0-8993-ea0cae65e123" class="sf-depth-2 sf-no-children"><a href="/research/research-resources" class="sf-depth-2">Research Resources</a></li><li id="navigation-menu-link-content311ec98e-6232-4e22-9966-4a9ac796870a" class="sf-depth-2 sf-no-children"><a href="/research/training-education" class="sf-depth-2">Training & Education</a></li><li id="navigation-menu-link-content52b1ba41-94ea-4d84-9db7-7482b8f78f16" class="sf-depth-2 sf-no-children"><a href="/research/alliances" class="sf-depth-2">Alliances</a></li><li id="navigation-menu-link-contenta185af75-90a5-4cc4-813f-ef66f35e21ea" class="sf-depth-2 sf-no-children"><a href="/research/collaborate-with-ncats" class="sf-depth-2">Collaborate With NCATS</a></li></ul></li><li id="navigation-menu-link-content84a3cc1f-203d-4de6-ab26-d80c256b96dc" class="sf-depth-1 menuparent"><a href="/funding" class="sf-depth-1 menuparent">Funding</a><ul><li id="navigation-menu-link-content0a09bed2-3d99-4faf-b3c5-fc9a4878629a" class="sf-depth-2 sf-no-children"><a href="/funding/overview" class="sf-depth-2">Funding Overview</a></li><li id="navigation-menu-link-contentd85a1f38-7893-4e4a-8514-5b9e767983e2" class="sf-depth-2 sf-no-children"><a href="/funding/funding-opportunities" class="sf-depth-2">Open Funding Opportunities</a></li><li id="navigation-menu-link-content81e84c00-ef73-4aff-a15f-7728cc398801" class="sf-depth-2 sf-no-children"><a href="/funding/small-business-programs" class="sf-depth-2">Small Business Programs</a></li><li id="navigation-menu-link-content631a166b-650b-450f-97b4-9014d14935e9" class="sf-depth-2 sf-no-children"><a href="/funding/funding-policy-operating-guidelines" class="sf-depth-2">Funding Policy & Operating Guidelines</a></li><li id="navigation-menu-link-content5d56ebe7-b3e8-452a-bd30-df92b0deabef" class="sf-depth-2 sf-no-children"><a href="/funding/grant-information" class="sf-depth-2">Grant Information</a></li><li id="navigation-menu-link-content4429fdc9-e911-4022-b3dc-3f6a4980b9ff" class="sf-depth-2 sf-no-children"><a href="/funding/challenges" class="sf-depth-2">Challenges and Prize Competitions</a></li><li id="navigation-menu-link-content943fe682-94ff-4fcf-a6b0-32096d2b2d0e" class="sf-depth-2 sf-no-children"><a href="/funding/scientific-review" class="sf-depth-2">Scientific Review</a></li><li id="navigation-menu-link-content10496705-320e-4437-b2ba-ea2830b293d1" class="sf-depth-2 sf-no-children"><a href="/funding/conference-grant-information" class="sf-depth-2">Conference Grant Information</a></li></ul></li><li id="navigation-menu-link-contentea91f2ef-1b8d-4b1c-83e7-5830769dd505" class="sf-depth-1 menuparent"><a href="/resources" class="sf-depth-1 menuparent">Resources For You</a><ul><li id="navigation-menu-link-content567e64e3-685d-41bc-8bf4-130c7689d6a2" class="sf-depth-2 sf-no-children"><a href="/resources/overview" title="Resources for You" class="sf-depth-2">Resources for You</a></li><li id="navigation-menu-link-content786ce1f5-ff7a-463a-bb05-c01882062426" class="sf-depth-2 sf-no-children"><a href="/resources/for-researchers" title="Resources for Researchers" class="sf-depth-2">Resources for Researchers</a></li><li id="navigation-menu-link-contente737ec67-ecd0-4f18-915d-b61660cb524f" class="sf-depth-2 sf-no-children"><a href="/resources/for-trainees" title="Resources for Trainees" class="sf-depth-2">Resources for Trainees</a></li><li id="navigation-menu-link-content8812fdb6-0fb7-4b27-8401-2fc5b3f41ff1" class="sf-depth-2 sf-no-children"><a href="/resources/for-rare-disease-patients-and-advocates" title="Resources for Rare Disease Patients and Advocates" class="sf-depth-2">Resources for Rare Disease Patients and Advocates</a></li></ul></li><li id="navigation-menu-link-contenta8527040-df23-4117-a5a7-566bd83e2c7f" class="sf-depth-1 menuparent"><a href="/news-events" class="sf-depth-1 menuparent">News & Events</a><ul><li id="navigation-menu-link-contentf6836a81-a42a-4528-b569-18939d8451da" class="sf-depth-2 sf-no-children"><a href="/news-events/overview" class="sf-depth-2">News & Events Overview</a></li><li id="navigation-menu-link-content9f44edc6-e5b7-4a92-bcb3-c0a8777461f4" class="sf-depth-2 sf-no-children"><a href="/news-events/news" class="sf-depth-2">News</a></li><li id="navigation-menu-link-content402cff9f-12b7-459b-9f0f-56606930399c" class="sf-depth-2 sf-no-children"><a href="/news-events/newsletter" class="sf-depth-2">Newsletters</a></li><li id="navigation-menu-link-content6cd76cbe-053e-4e3b-8961-c9f5def57ba6" class="sf-depth-2 sf-no-children"><a href="/news-events/events" class="sf-depth-2">Events</a></li><li id="navigation-menu-link-content0a211675-2fb5-45cc-b443-c7946e7d9120" class="sf-depth-2 sf-no-children"><a href="/news-events/science-publications" class="sf-depth-2">Scientific Publications</a></li><li id="navigation-menu-link-contente6d4ed4f-826f-41b4-a9e2-728c2fb4ca62" class="sf-depth-2 sf-no-children"><a href="/news-events/multimedia" class="sf-depth-2">Multimedia</a></li></ul></li><li id="navigation-menu-link-contentf1eb1fa8-5813-433c-9bcc-dc56f2e258f3" class="sf-depth-1 menuparent"><a href="/about" class="sf-depth-1 menuparent">About NCATS</a><ul><li id="navigation-menu-link-contentada9a195-ae5a-446a-9014-c1232164e6db" class="sf-depth-2 sf-no-children"><a href="/about/ncats-overview" class="sf-depth-2">NCATS Overview</a></li><li id="navigation-menu-link-contentd5e0369a-aded-4348-84f7-463c64498447" class="sf-depth-2 sf-no-children"><a href="/about/about-translational-science" class="sf-depth-2">About Translational Science</a></li><li id="navigation-menu-link-contente298b7b2-724e-408b-9bb9-afcaac57a751" class="sf-depth-2 sf-no-children"><a href="/about/advisory-committees" class="sf-depth-2">Advisory Committees</a></li><li id="navigation-menu-link-contentbc9c91b7-8d3d-4d2c-af65-c25ef894d269" class="sf-depth-2 sf-no-children"><a href="/about/budget" class="sf-depth-2">Budget</a></li><li id="navigation-menu-link-contenta4ed4439-05db-4a41-9357-731c2ff74543" class="sf-depth-2 sf-no-children"><a href="/about/director" class="sf-depth-2">Director's Corner</a></li><li id="navigation-menu-link-contentb50f96af-3723-4634-8566-4e60c2639491" class="sf-depth-2 sf-no-children"><a href="/about/divisions-and-offices" class="sf-depth-2">Divisions & Offices</a></li><li id="navigation-menu-link-content41d11ad4-c576-46be-a326-1f8cf5059354" class="sf-depth-2 sf-no-children"><a href="/about/our-staff" class="sf-depth-2">Our Staff</a></li></ul></li>
|
||
</ul>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="desktop:grid-col-2 search-block">
|
||
<form class="usa-search usa-search--small" action="/search/node" method="get" id="search-block-form" accept-charset="UTF-8">
|
||
<div role="search">
|
||
|
||
<input class="usa-input" id="extended-search-field-small" type="search" name="keys" />
|
||
<button class="usa-button" type="submit">
|
||
<img src="/themes/custom/d9_subtheme/node_modules/@uswds/uswds/dist/img/usa-icons-bg/search--white.svg" class="usa-search__submit-icon" alt="Search">
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div></div>
|
||
</div>
|
||
|
||
|
||
<nav class="usa-nav" role="navigation">
|
||
<div class="usa-nav__inner">
|
||
|
||
<button type="button" class="usa-nav__close">
|
||
<img src="/themes/custom/d9_subtheme/node_modules/@uswds/uswds/dist/img/usa-icons/close.svg" alt="close"/>
|
||
</button>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</nav>
|
||
|
||
|
||
</header>
|
||
|
||
<main class="main-content usa-layout-docs usa-section " role="main"
|
||
id="main-content">
|
||
|
||
<div class="grid-container-">
|
||
|
||
<div class="grid-row">
|
||
|
||
</div>
|
||
|
||
<div class="">
|
||
|
||
</div>
|
||
|
||
<div class="grid-row ">
|
||
|
||
</div>
|
||
|
||
<div class="grid-row grid-gap">
|
||
|
||
<div class="usa-layout-docs__main desktop:grid-col-fill">
|
||
<div class="">
|
||
<div data-drupal-messages-fallback class="hidden"></div>
|
||
<div id="block-d9-subtheme-content" class="block block-system block-system-main-block">
|
||
|
||
|
||
<article data-history-node-id="27695">
|
||
|
||
|
||
|
||
|
||
|
||
<div>
|
||
<div class="container layout layout--onecol">
|
||
<div class="layout__region layout__region--content">
|
||
<div class="block block-system block-system-breadcrumb-block">
|
||
|
||
|
||
<nav class="usa-breadcrumb" role="navigation" aria-labelledby="system-breadcrumb">
|
||
<h2 id="system-breadcrumb" class="usa-sr-only">Breadcrumb</h2>
|
||
<ol class="usa-breadcrumb__list">
|
||
<li class="usa-breadcrumb__list-item">
|
||
<a href="/" class="usa-breadcrumb__link"><span>Home</span></a>
|
||
</li>
|
||
<li class="usa-breadcrumb__list-item">
|
||
<a href="/research/overview" class="usa-breadcrumb__link"><span>Research</span></a>
|
||
</li>
|
||
<li class="usa-breadcrumb__list-item">
|
||
<a href="/research/research-activities" class="usa-breadcrumb__link"><span>Research Activities</span></a>
|
||
</li>
|
||
<li class="usa-breadcrumb__list-item">
|
||
<a href="/research/research-activities/compound-management" class="usa-breadcrumb__link"><span>Compound Management</span></a>
|
||
</li>
|
||
<li class="usa-breadcrumb__list-item">
|
||
<span>Chemical Libraries: Genesis and NPACT</span>
|
||
</li>
|
||
</ol>
|
||
</nav>
|
||
|
||
</div>
|
||
<div class="block block-layout-builder block-field-blocknodelanding-page-new-field-metatag">
|
||
|
||
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="layout layout--onecol">
|
||
<div class="layout__region layout__region--content">
|
||
<div class="block block-layout-builder block-field-blocknodelanding-page-new-field-landing-page-components">
|
||
|
||
|
||
|
||
|
||
|
||
<section class="main-hero" style="background-image:
|
||
linear-gradient(to left, rgba(255,255,255, 0.1), rgba(0, 0, 0, 0.99)),
|
||
url('/sites/default/files/2023-09/Compound%20Management_1440x350.png');">
|
||
<div class="container">
|
||
<div class="row">
|
||
<div class="col-12">
|
||
<div class="hero-content">
|
||
<h1>Chemical Libraries</h1>
|
||
<p class="text-white">
|
||
|
||
We have assembled high-value, modern chemical libraries to advance translational science.
|
||
</p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
<style type="text/css">
|
||
article {position: relative;}
|
||
.block-system-breadcrumb-block{
|
||
position:absolute;
|
||
top:0;
|
||
color:#fff;
|
||
}
|
||
.block-system-breadcrumb-block .usa-breadcrumb__list, .block-system-breadcrumb-block .usa-breadcrumb__list a {
|
||
color:#fff;
|
||
}
|
||
.block-system-breadcrumb-block .usa-breadcrumb__list .usa-breadcrumb__list-item:after {
|
||
background-color:#fff !important;
|
||
}
|
||
</style>
|
||
<div class="container subnav">
|
||
|
||
|
||
<nav role="navigation" aria-labelledby="block-navigation-menu" id="block-navigation">
|
||
|
||
<h2 class="usa-sr-only" id="block-navigation-menu">Navigation</h2>
|
||
|
||
|
||
|
||
<ul class="menu menu--navigation nav">
|
||
<li class="active active-trail first last">
|
||
<a href="/research/research-activities/compound-management/chemical-libraries" class="active active-trail first last active-trail is-active" data-drupal-link-system-path="node/27695">Chemical Libraries: Genesis and NPACT</a>
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
</nav>
|
||
|
||
|
||
</div>
|
||
|
||
<section>
|
||
<div class="container news-content Advancing">
|
||
<h2 class="section-heading">Chemical Libraries: About Genesis and NPCAT </h2>
|
||
|
||
|
||
<div class="paragraph paragraph--type--body-content paragraph--view-mode--default">
|
||
|
||
|
||
<div class="contact-box"><h4>Contact</h4><p><a href="mailto:kelli.wilson@nih.gov"><u>Kelli M. Wilson, Ph.D.</u></a></p></div><h3>Genesis: Modern Chemical Library to Enable Large-Scale Deorphanization of Novel Biological Mechanisms</h3><p><strong>Contact: </strong><a href="mailto:ETB@mail.nih.gov" title="email the ETB Team">Early Translation Branch</a> <br><strong>Library Size: </strong>100K compounds <br><strong>Format: </strong>1,536-well plates in dose-response format <br><strong>Availability: </strong>Accessed through collaboration with NCATS</p><p><strong>Description:</strong> Genesis Chemical Library: The collection is plated in quantitative high-throughput screening (qHTS) format, enabling large-scale deorphanization of unprecedented mechanisms. Bioactives identified from Genesis screening provide a high-quality starting point for medicinal chemistry optimization of proof-of-concept tool compounds or therapeutic leads. The library consists of more than 1,000 scaffolds that vary in representation from 20 to 100 compounds per chemotype. The modern nature of the library incorporates years of valuable lessons learned on chemical library design. A portion of the library includes many sp3-enriched chemotypes that are inspired by naturally occurring compounds. Such chemotypes retain the pharmacophore found in natural products while reducing the extreme complexity, making them synthetically tractable. The chemotype includes spirocyclic compounds as well as non-spiro novel chemotypes that either do not exist in literature or patent space or are scarcely found. This novelty provides a distinct advantage in the development of potential intellectual property, as well as providing opportunities for first-in-class compounds. Yet another feature of Genesis is that, given the need for rapid derivatization in medicinal chemistry, the library has been designed with core scaffolds that are purchasable commercially. This allows for optimization around what would otherwise be complex synthetic cores. Genesis’ compound space is largely non-overlapping with PubChem or any publicly available chemical library. Its overall library composition provides shape and electrostatic diversity while keeping known drug-like properties, such as solubility, lipophilicity, hydrogen bond donor/acceptor status and molecular weight, in check.</p><h3>NPACT Chemical Library — Innovative Chemical Biology Library for Translational Sciences</h3><p><strong>Library Size: </strong>11K compounds <br><strong>Format: </strong>1,536-well and 384-well plates in dose-response format <br><strong>Availability:</strong> Accessed through collaboration with NCATS </p><p><strong>Description:</strong> NCATS Pharmacologically Active Chemical Toolbox (NPACT): NPACT is a world-class small molecule library of high-quality organism-agnostic and pharmacologically active agents, whether they are naturally occurring, nature inspired or synthetically created. The NPACT library consists of annotated compounds that inform on novel phenotypes, biological pathways and cellular processes. There are more than 7,000 mechanisms and phenotypes identified in the literature and worldwide patents that cover biological interactions within mammalian, microbial, plant and other model systems. The NPACT library of more than 11,000 compounds aims to cover as many of these biological mechanisms as possible, allowing for broad profiling of mechanism-to-phenotype associations. Many of the known mechanisms are represented by a few best-in-class compounds with non-redundant chemotypes that provide a diversity of physicochemical and pharmacological properties. The chemical classes include both synthetically derived small molecules and microbial- and plant-derived purified natural products. The clinical and basic research scope includes all quality-approved and investigational drugs, as well as all tool compounds that have varying degrees of validation as therapeutic or fundamental chemical biology approaches. NPACT continues to be dynamic and current with the state of translational research as new biological processes, mechanisms, and approaches are revealed in patents and literature.</p>
|
||
|
||
</div>
|
||
|
||
|
||
|
||
</div>
|
||
</section>
|
||
|
||
|
||
</div>
|
||
<div class="block block-layout-builder block-extra-field-blocknodelanding-page-new-content-moderation-control">
|
||
|
||
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</article>
|
||
|
||
</div>
|
||
<div id="block-footercss" class="block block-block-content block-block-content2db33373-6fb7-49c5-be2f-83266eddea39">
|
||
|
||
|
||
|
||
|
||
<style type="text/css">
|
||
ul#superfish-navigation li { line-height:1.25; }
|
||
.region-header .block-superfish ul.sf-menu li a {padding-right:40px !important;}
|
||
@media (min-width: 1200px) {
|
||
ul.sf-menu.sf-navigation li.menuparent ul {width:280px !important;}
|
||
}
|
||
.main-content article .menu--navigation {
|
||
display:flex;
|
||
flex-wrap: nowrap;
|
||
justify-content: space-between;
|
||
align-items: stretch;
|
||
}
|
||
.main-content article .menu--navigation li {
|
||
flex: 1 1 0;
|
||
width: 0;
|
||
align-items: center;
|
||
display: flex;
|
||
justify-content: center;
|
||
}
|
||
.main-content article .menu--navigation li .dropdown-toggle {
|
||
white-space: unset;
|
||
}
|
||
.image-box img,
|
||
div.col-md-4.col-lg-2 img {
|
||
height: auto;
|
||
}
|
||
.caption-left-md {
|
||
float: left;
|
||
width: 50%;
|
||
margin: 0 1% 2% 0;
|
||
border: 1px solid #ddd;
|
||
}
|
||
.caption-left-md img {
|
||
width: 100%!important;
|
||
height: auto;
|
||
}
|
||
div.block.block-layout-builder.block-field-blocknodestafffield-divisions-office {
|
||
display: none
|
||
}
|
||
@media (max-width: 992px) {
|
||
.main-content article .menu--navigation {
|
||
flex-direction:column;
|
||
}
|
||
.main-content article .menu--navigation li {
|
||
display:inline-block;
|
||
margin:0;
|
||
padding:.25rem;
|
||
width: auto;
|
||
text-align:left;
|
||
}
|
||
.main-content article .menu--navigation li:hover, .main-content article .menu--navigation li.active {
|
||
border-bottom: 4px solid transparent !important;
|
||
}
|
||
.main-content article .menu--navigation li:hover a, .main-content article .menu--navigation li.active a {
|
||
border-bottom:4px solid #00626f !important;
|
||
padding-bottom:4px;
|
||
}
|
||
}
|
||
p.last-update-container {
|
||
font-size: 15px;
|
||
font-style: italic;
|
||
}
|
||
</style>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</main>
|
||
<div>
|
||
<div id="block-d9-subtheme-lastupdateblock" class="block block-ncats-common block-last-update-block">
|
||
|
||
|
||
<div class="container"><p class="last-update-container">Last updated on April 19, 2024</p></div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<footer class="pt-4 footer mt-4">
|
||
<div class="container">
|
||
<div class="row">
|
||
<div class="col-12 py-4">
|
||
<img src="/sites/default/files/2023-10/ncats-logo-footer.png" class="img-fluid" alt="NCATS">
|
||
</div>
|
||
</div>
|
||
|
||
<div class="row">
|
||
<div class="container">
|
||
<div class="row justify-content-between">
|
||
<div class="col-xl-4">
|
||
<div class="pt-4">
|
||
<address>
|
||
9609 Medical Center Drive<br>
|
||
Rockville, MD 20850-9793<br>
|
||
301-594-8966<br>
|
||
<a href="mailto:ncatsinfo@nih.gov">ncatsinfo@nih.gov</a>
|
||
</address>
|
||
</div>
|
||
|
||
<div class="text-white social-links mt-4">
|
||
<h5>Connect with us</h5>
|
||
<ul id="social-media-icons" class="list-unstyled d-flex mb-4">
|
||
<li><a href="http://www.facebook.com/ncats.nih.gov" title="Visit us on Facebook" target="_blank"><i class="bi bi-facebook"></i></a></li>
|
||
<li><a href="https://www.linkedin.com/company/nih-ncats" title="Visit us on LinkedIn" target="_blank"><i class="bi bi-linkedin"></i></a></li>
|
||
<li><a href="http://www.twitter.com/ncats_nih_gov" title="Visit us on X" target="_blank"><i class="bi bi-twitter-x"></i></a></li>
|
||
<li><a href="http://www.youtube.com/user/ncatsmedia" title="View our videos on YouTube" target="_blank"><i class="bi bi-youtube"></i></a></li>
|
||
<li><a href="https://www.flickr.com/photos/64860478@N05/" target="_blank" title="View our photos on Flickr"><img src="/sites/default/files/2023-10/flickr.png" alt="View our photos on Flickr" style="height:24px;"></a></li>
|
||
</ul>
|
||
<p class="small">For <a href="http://edi.nih.gov/consulting/language-access-program/about" target="_blank">language access assistance</a>, contact the <a href="mailto:ncatsinfo@nih.gov">NCATS Public Information Officer</a></p>
|
||
</div>
|
||
|
||
</div>
|
||
<div class="col-xl-3 text-white mt-5 d-lg-none d-sm-none d-none d-xl-block">
|
||
<div id="mc_embed_shell">
|
||
|
||
<div id="mc_embed_signup">
|
||
<form action="https://nih.us5.list-manage.com/subscribe/post?u=e06bd55ccbb41f1a362306dff&id=d32fa404b4&f_id=0087b1edf0" method="post" id="mc-embedded-subscribe-form" name="mc-embedded-subscribe-form" class="validate" target="_blank">
|
||
<h5>Subscribe to NCATS News</h5>
|
||
<p>If you would like to stay up to date with the latest information from us, please sign up for NCATS News.</p>
|
||
<div id="mce-responses" class="clear">
|
||
<div class="response" id="mce-error-response" style="display: none;"></div>
|
||
<div class="response" id="mce-success-response" style="display: none;"></div>
|
||
</div>
|
||
<div class="input-group mb-3">
|
||
<input type="email" name="EMAIL" class="required email form-control" id="mce-EMAIL" required="" value="" placeholder="Enter Email" aria-label="Recipient's username" aria-describedby="button-addon2" tabindex="-1">
|
||
|
||
<div aria-hidden="true" style="position: absolute; left: -5000px;"><input type="text" name="b_e06bd55ccbb41f1a362306dff_d32fa404b4" tabindex="-1" value=""></div>
|
||
<button type="submit" name="subscribe" id="mc-embedded-subscribe" class="button btn" value="Subscribe">Submit</button>
|
||
</div>
|
||
|
||
</form>
|
||
</div>
|
||
<script type="text/javascript" src="//s3.amazonaws.com/downloads.mailchimp.com/js/mc-validate.js"></script><script type="text/javascript">(function($) {window.fnames = new Array(); window.ftypes = new Array();fnames[0]='EMAIL';ftypes[0]='email';fnames[1]='FNAME';ftypes[1]='text';fnames[2]='LNAME';ftypes[2]='text';fnames[3]='SIGNUP';ftypes[3]='text';}(jQuery));var $mcj = jQuery.noConflict(true);</script></div>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
<!-- footer menu section -->
|
||
|
||
<section class="footer-menu py-3 mb-xl-0 mb-lg-0 mb-sm-5 mt-4">
|
||
<div class="container">
|
||
<div class="row">
|
||
<div class="col-12">
|
||
<ul class="list-unstyled d-xl-flex d-lg-flex d-sm-block d-block justify-content-center mb-0">
|
||
<li><a href="https://ncats.nih.gov/">NCATS Home</a></li>
|
||
<li><a href="/sitemap">Site Map</a></li>
|
||
<li><a href="/privacy">Privacy Notice</a></li>
|
||
<li><a href="/comments">Comment Policy</a></li>
|
||
<li><a href="/accessibility">Accessibility</a></li>
|
||
<li><a href="/foia">FOIA</a></li>
|
||
<li><a href="http://oig.hhs.gov/" target="_blank">OIG</a></li>
|
||
<li class="border-0"><a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" target="_blank">HHS Vulnerability Disclosure</a></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
</footer>
|
||
|
||
</div>
|
||
|
||
|
||
<script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","pathPrefix":"","currentPath":"node\/27695","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"en"},"pluralDelimiter":"\u0003","suppressDeprecationErrors":true,"ajaxPageState":{"libraries":"eJx1kFGOwzAIRC_kjb_3NBaJqeMWGwtw29y-jtTutqvsz2jmjQCJ-B20z7ZiQQ-qaOriG8K7oVSgLxiyWV7UDUS5XnyU3oCmZ3SJOREGg-TTkL95gjPcP2FxBBt3CzHrwleUzXPFhck1EEgCbdXXlV8y9dr6TFlXjE57QzkN73_cEQvrvj5Xw2qHvRYg0kUQ63G_u_EU_a9trNkyj-lNDYufQdF1vUUNu_UngYI3lssDdIKSjQ","theme":"d9_subtheme","theme_token":null},"ajaxTrustedUrl":[],"gtm":{"tagId":null,"settings":{"data_layer":"dataLayer","include_classes":false,"allowlist_classes":"","blocklist_classes":"","include_environment":false,"environment_id":"","environment_token":""},"tagIds":["GTM-55CGV66V"]},"gtag":{"tagId":"G-ZZQ8H5G8ZX","otherIds":[],"events":[],"additionalConfigInfo":[]},"data":{"extlink":{"extTarget":true,"extTargetNoOverride":false,"extNofollow":false,"extNoreferrer":true,"extFollowNoOverride":false,"extClass":"ext","extLabel":"(link is external)","extImgClass":false,"extSubdomains":true,"extExclude":"","extInclude":"","extCssExclude":"","extCssExplicit":"","extAlert":true,"extAlertText":"You are leaving the NIH website.\r\n\r\nThis external link provides additional information that is consistent with the intended purpose of this site. NIH cannot attest to the accuracy of a non-federal site.\r\n\r\nLinking to a non-federal site does not constitute an endorsement by NIH or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site\u0027s privacy policy when you follow the link.","mailtoClass":"mailto","mailtoLabel":"(link sends email)","extUseFontAwesome":false,"extIconPlacement":"append","extFaLinkClasses":"fa fa-external-link","extFaMailtoClasses":"fa fa-envelope-o","whitelistedDomains":[]}},"superfish":{"superfish-navigation":{"id":"superfish-navigation","sf":{"animation":{"opacity":"show","height":"show"},"speed":"fast"},"plugins":{"smallscreen":{"mode":"window_width","accordionButton":0,"title":"Navigation"},"supposition":true,"supersubs":true}}},"user":{"uid":0,"permissionsHash":"24b2a698a72e7a44d4f2d94d9880a6ba82bfbc8b8200dee23422144335254cbc"}}</script>
|
||
<script src="/core/assets/vendor/jquery/jquery.min.js?v=3.7.1"></script>
|
||
<script src="/core/assets/vendor/once/once.min.js?v=1.0.1"></script>
|
||
<script src="/core/misc/drupalSettingsLoader.js?v=10.2.3"></script>
|
||
<script src="/core/misc/drupal.js?v=10.2.3"></script>
|
||
<script src="/core/misc/drupal.init.js?v=10.2.3"></script>
|
||
<script src="/core/assets/vendor/tabbable/index.umd.min.js?v=6.2.0"></script>
|
||
<script src="https://cdn.jsdelivr.net/npm/@uswds/uswds@3.3.0/dist/js/uswds.min.js"></script>
|
||
<script src="/core/misc/progress.js?v=10.2.3"></script>
|
||
<script src="/core/assets/vendor/loadjs/loadjs.min.js?v=4.2.0"></script>
|
||
<script src="/core/misc/debounce.js?v=10.2.3"></script>
|
||
<script src="/core/misc/announce.js?v=10.2.3"></script>
|
||
<script src="/core/misc/message.js?v=10.2.3"></script>
|
||
<script src="/core/misc/ajax.js?v=10.2.3"></script>
|
||
<script src="/themes/custom/d9_subtheme/js/script.js?v=10.2.3"></script>
|
||
<script src="/modules/contrib/extlink/extlink.js?v=10.2.3"></script>
|
||
<script src="/modules/contrib/google_tag/js/gtm.js?srmo5o"></script>
|
||
<script src="/modules/contrib/google_tag/js/gtag.js?srmo5o"></script>
|
||
<script src="/modules/contrib/google_tag/js/gtag.ajax.js?srmo5o"></script>
|
||
<script src="/libraries/drupal-superfish/superfish.js?srmo5o"></script>
|
||
<script src="/libraries/drupal-superfish/jquery.hoverIntent.minified.js?srmo5o"></script>
|
||
<script src="/libraries/drupal-superfish/sfsmallscreen.js?srmo5o"></script>
|
||
<script src="/libraries/drupal-superfish/supposition.js?srmo5o"></script>
|
||
<script src="/libraries/drupal-superfish/supersubs.js?srmo5o"></script>
|
||
<script src="/modules/contrib/superfish/js/superfish.js?v=2.0"></script>
|
||
|
||
</body>
|
||
</html>
|