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<a href="/research/research-activities/bridgs/work/prior-proposals" class="last" data-drupal-link-system-path="node/28440">Updates to Prior BrIDGs Proposals</a>
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<div class="container news-content Advancing">
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<h2 class="section-heading">BrIDGs Project Implementation and Conduct</h2>
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<div class="contact-box"><p><strong>Contact</strong></p><p><a href="mailto:BrIDGs@mail.nih.gov" title="BrIDGs Program Staff">BrIDGs Program Staff</a></p></div><p>After a proposal is approved, BrIDGs staff work with the principal investigator to develop a plan for the conduct of proposed studies. Development proceeds in order in most cases, and the start of one segment of the project (e.g., toxicology) depends on satisfactory completion of previous segments (e.g., formulation).</p><p>Once a plan is in place, BrIDGs staff assign studies to existing contractors or competitively brings in new contracts as needed. Selected contractors perform tasks under the direction of BrIDGs scientists. Principal investigators receive monthly study updates. Meetings or conference calls may be held as needed with the principal investigator to discuss the direction of the project. BrIDGs staff provide final study reports, as they become available, in a format ready for an Investigational New Drug (IND) application. Although BrIDGs staff do not provide formal regulatory affairs assistance, staff can provide advice on filing the IND and participate in pre-IND meetings, if desired.</p><p>The principal investigator or a third-party collaborator is responsible for filing the IND application. After the IND clears, BrIDGs staff will release to the principal investigator any clinical trial material developed during the collaboration. Investigators are responsible for securing resources for the funding and conduct of clinical trials enabled by BrIDGs data and material. </p><h2>Material and Data Transfer</h2><p>The output of BrIDGs activities, in the form of research material and data, is available to the partnering organization to support its IND application and clinical trials. Data and material will be transferred under the terms of a <a href="/research/alliances/forms-and-model-agreements">partnership agreement</a>.</p><h2>Intellectual Property</h2><p>Working partners are urged to pursue licensing discussions with third parties throughout the partnership with BrIDGs. If a licensing agreement is completed, the principal investigator from the partnering organization will continue to serve as the point of contact for the project. The licensee can participate in project meetings and decisions, with the permission of the principal investigator.</p><p><a href="/research/research-activities/BriDGs/work/intellectual-property">Learn more about intellectual property and BrIDGs collaborations</a>. </p><h2>Project Delays and Discontinuations</h2><p>BrIDGs is not a complete drug development program or an unconditional commitment to develop a particular therapeutic agent for the clinic. The partnership may go through difficulties that are scientific (e.g., unwieldy synthesis, poor safety margin, unanticipated toxicity) or administrative (e.g., cuts to program funding or contract capacity). Insurmountable difficulties encountered during the development process may force the delay or discontinuation of an entire working relationship.</p>
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